LOCUS       NZ_CP084681            22106 bp    DNA     linear   CON 30-APR-2024
DEFINITION  Streptomyces inhibens strain NRRL30439 chromosome, complete genome.
ACCESSION   NZ_CP084681
VERSION     NZ_CP084681.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces inhibens
  ORGANISM  Streptomyces inhibens
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9696490)
  AUTHORS   Barry,C.P., Gillane,R., Talbo,G.H., Plan,M., Palfreyman,R.,
            Haber-Stuk,A.K., Power,J., Nielsen,L.K. and Marcellin,E.
  TITLE     Multi-omic characterisation of Streptomyces hygroscopicus NRRL
            30439: detailed assessment of its secondary metabolic potential
  JOURNAL   Mol Omics 18 (3), 226-236 (2022)
   PUBMED   34989730
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9696490)
  AUTHORS   Barry,C.P., Palfreyman,R. and Marcellin,E.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-OCT-2021) EMS, Australian Institute for Bioengineering
            and Nanotechnology, Cnr College Rd & Cooper Rd, Brisbane, Queensland
            4103, Australia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. APRIL-2018
            Assembly Name                     :: AIBN_shyg
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 239.0x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022221585.1-RS_2024_04_30
            Annotation Date                   :: 04/30/2024 04:58:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,775
            CDSs (total)                      :: 8,682
            Genes (coding)                    :: 8,305
            CDSs (with protein)               :: 8,305
            Genes (RNA)                       :: 93
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 377
            CDSs (without protein)            :: 377
            Pseudo Genes (ambiguous residues) :: 0 of 377
            Pseudo Genes (frameshifted)       :: 158 of 377
            Pseudo Genes (incomplete)         :: 310 of 377
            Pseudo Genes (internal stop)      :: 38 of 377
            Pseudo Genes (multiple problems)  :: 116 of 377
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:32:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 423261
            Orig. end                         :: 445367
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP084681.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Australian Institute for
            Bioengineering and Nanotechnology, Building 75,Cnr College Rd &
            Cooper Rd, Brisbane City QLD 4072.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22106
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="4"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22106
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22106
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12106](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12106)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     gene            427..1125
                     /locus_tag="KI385_RS02005"
                     /old_locus_tag="KI385_02005"
     CDS             427..1125
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004952314.1"
                     /locus_tag="KI385_RS02005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02005"
                     /product="aspartate/glutamate racemase family protein"
                     /protein_id="WP_238577538.1"
                     /transl_table=11
                     /translation="MKTIGLLGGMSWESTAEYYRLLNQLTRDRLGGLHSSRCVLYSVDF
                     AEIEQLQVEGRWEQAAEVLAEAARALESAGVDMLLICTNTMHKVADQVAAAVGIPLLHL
                     ADTTADAVRANGLRRIGLLGTAFTMEQDFYRGRLESHGLEVLVPDAAGRSTVHRVIYEE
                     LCLGIVHEESRKSFMAIIGELVAAGAEGIVLGCTEIELLIGPEHSPVPVFPTTRLHAEA
                     AVTLALTDVP"
     gene            1279..1602
                     /locus_tag="KI385_RS02010"
                     /old_locus_tag="KI385_02010"
     CDS             1279..1602
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KI385_RS02010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KI385_02010"
                     /product="hypothetical protein"
                     /protein_id="WP_238570509.1"
                     /transl_table=11
                     /translation="MSRSELERLARIRMQVTGESLERAMAVLQGHPTDSGPEPEPEPGR
                     EQELGQGPGLGRGLEPESASEPDENGAVDDTGTSSEGSEADATPAEPDARPTPQRRSHL
                     RGL"
     gene            complement(1873..2106)
                     /locus_tag="KI385_RS02015"
                     /old_locus_tag="KI385_02015"
     CDS             complement(1873..2106)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018537369.1"
                     /locus_tag="KI385_RS02015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02015"
                     /product="DUF6296 family protein"
                     /protein_id="WP_238570510.1"
                     /transl_table=11
                     /translation="MEDYPECYELVFQAPAVEDDVVIVRRTERAGAGGYPVYEDESGIV
                     RAEISDRGEVRMLASGGHQVPRTPMLARRLTH"
     misc_feature    2068..2084
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.42"
                     /tool="antismash"
     misc_feature    complement(2231..2245)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.69"
                     /tool="antismash"
     gene            2418..3734
                     /locus_tag="KI385_RS02020"
                     /old_locus_tag="KI385_02020"
     CDS             2418..3734
                     /EC_number="3.1.1.103"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015576587.1"
                     /locus_tag="KI385_RS02020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02020"
                     /product="serine hydrolase domain-containing protein"
                     /protein_id="WP_238570511.1"
                     /transl_table=11
                     /translation="MPVTPAHRRRVRLAGTATAALLALMVPTAASAASAPALPAGNATA
                     MPADRAGLDRAALDATLRAFHDAGMYGAYSAVRDGTEQWQGAAGVADVDTGRPTTPQMR
                     HRIGSITKTFTAAAVLQEVGKGHIELDAPIGRYLPDLVPGERGRAITVRMLLNHTSGIG
                     DYGGAIFATPESLEGNRFHQFDPRELARLGLKARPLGSPGQAHHYSNTNYVIAGLLLQR
                     ITGESPETYITEHVIRKAGLQHTYFPRSAYITGPHAKMYEAAYGDFNPPRDFSVYNLSW
                     AGTAGSLVSTMADLNRFYRALLHGHLLAPAQLRQMKTTVPMEGSAVRYGLGLGLFKMAL
                     PCGEFWGHDGLVPGAMTWSLSTADGRRQISLGYNLTHYQKLDSNDRPKAGPIDAAMDTH
                     LVQALCGTSGSLRAGHPGTSGTLPLHTSPQEPSLAVHHQ"
     misc_feature    2478..2480
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            4020..4403
                     /locus_tag="KI385_RS02025"
                     /old_locus_tag="KI385_02025"
     CDS             4020..4403
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003959111.1"
                     /locus_tag="KI385_RS02025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02025"
                     /product="VOC family protein"
                     /protein_id="WP_238570512.1"
                     /transl_table=11
                     /translation="MAVAGRPRFSLATVVVDCPDAQALADFYRRLLGWEVKFSEPDWVL
                     LRCPDGGTGLSFQSEPEYRAPVWPERPEEQQKMLHLDIWVDDLVEAEAYAVSVGARRAE
                     FQPQDDVRVFFDPAGHPFCLFLH"
     gene            complement(4987..5982)
                     /locus_tag="KI385_RS02030"
                     /old_locus_tag="KI385_02030"
     CDS             complement(4987..5982)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014059075.1"
                     /locus_tag="KI385_RS02030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02030"
                     /product="chitinase"
                     /protein_id="WP_238570513.1"
                     /transl_table=11
                     /translation="MNQPHRSRSLPIALSLLLLGAAAAMGADGAAATPRAVVPMAAAPY
                     EYLGWGNPQTPTDVMAATGTKTFTLAFILSDGGCNPKWDGSRALTGGSDESAIKSIRAK
                     GGDVVVSVGGWSGAKLGEKCGSASALAGAYQKVIDAYRLKALDVDIENTEFTNATVRKR
                     VIDALKIVKAKNPGIITYLTMGTTPNGPDSNGKDLIKKGAAAGLDNDGWVVMPFDFGGH
                     SGTMGQATVSALEGLKAAVKNSYGYGDADAYRHIGVSSMNGKTDDADETVTLADFRTIL
                     GYAQQHHIARFAFWSVNRDRPCGSGSDGDSCSGVSQDPYAYTKIVAKYLG"
     misc_feature    5999..6013
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.6"
                     /tool="antismash"
     gene            complement(6053..7840)
                     /locus_tag="KI385_RS02035"
                     /old_locus_tag="KI385_02035"
     CDS             complement(6053..7840)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056904.1"
                     /locus_tag="KI385_RS02035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02035"
                     /product="discoidin domain-containing protein"
                     /protein_id="WP_238570514.1"
                     /transl_table=11
                     /translation="MRAYAVVLAVLALLLGALALPGTAYADLQHPRQNFLRGSVSGLFL
                     HWGERTAPQHTSCSGWEKDVTAGGWSPDYWVKEAGKLHAQYLVLASFHSRLGYARSWPS
                     KIPGSCHTRRDFLGELITAAKAKGLKVILYMTDDPQWHNDGGHEWLDSDGYSRYKGRNV
                     DLTTRDGFGEFSYENFFEVMERYPELGGFWIDNDNDYWLDHHLYERIYRLRPRYTLSNN
                     NEDTSVMDMISNEQKTGMSPSYDYPQATYTAAPRLTEADFKLPSSGAWWYDGSDPAVDR
                     RLTLGRLITNAGSSIKALMAETAQVNGRFPAKQEAFNNFADGYLDGIWESLRGTEGGGY
                     LHGGLAPGFWNDDAHGVTTLSTTDPNRHYVHVITPPSTSTLRLRDNGYRVAEVTDLRTG
                     ARIPFTQSGGSLTLSGLGDWDPYDTVFKVTTAGRQGILPATSYTMSASAAADGHPASAA
                     GDGDHLTYWDNDRTLPVSLTYALGADRSVRYLGINQREDSVSYARSDTEQSARIKEYRV
                     YASEDGTHWGSPVKTGTLPSHRAVSFIDLPATTTTRYVRLEVRSTYAAASDATRYRRLR
                     VDETWVGTRYAAPVSGGGR"
     gene            complement(7918..8676)
                     /locus_tag="KI385_RS02040"
                     /old_locus_tag="KI385_02040"
     CDS             complement(7918..8676)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KI385_RS02040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KI385_02040"
                     /product="hypothetical protein"
                     /protein_id="WP_238570515.1"
                     /transl_table=11
                     /translation="MGKRWAVGAALAAAVALGVGQPSVARTRSTGAAVRTGKADDSAAR
                     ERQAGRTALREFNVKDHGAAGNGSANDSGADTYDAPAPNANDDALVFKSDYALGAKLPN
                     GHVAVRDSRRSAKCGNALMFGSETCGDFTDCHFDRIAIVGADKSGLGMVSMDGAKIPDV
                     HYRDITMKNVHSPIMRKIGTRPAFGWYLRNVDGITVRDSSVRFAADDGRPAVIAHVAHK
                     LTFDHFTAQRGGKRPYDLGFPRARAVGGAR"
     gene            complement(8691..10004)
                     /locus_tag="KI385_RS02045"
                     /old_locus_tag="KI385_02045"
     CDS             complement(8691..10004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020119200.1"
                     /locus_tag="KI385_RS02045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02045"
                     /product="glycoside hydrolase family 88 protein"
                     /protein_id="WP_238570516.1"
                     /transl_table=11
                     /translation="MSVRVRGVLAAALLSCAALVCTALAVPNGTEPAAGSARGEAIVDA
                     GDAGDAGDAATVAGARTHAARSYTNADTSALGRPSPDRSATDWSTALVDSTLARYTPDK
                     IGGWSYPVGLYLYGQYLVYQRTHQQRYLDYIKQYVDRFVDSNGNIDQSFNSLDSMQAGR
                     LLVILHHETGAHRYQIAAQKIRKRLDSYPRTADGGFWHATSSSRAHQLWADGVYMVTPF
                     LVEYGKEFGDSAYADDEAAGQLAVYGGHLQHSSGLLRHAYDEAKTADWADTKTGQAPEH
                     WCRAVGWYAMADVTVLDALPADHPRRAQLTGILRKLASGLEKTQDPSSGRWFQVMDKGE
                     RPDNWTETSCSSMFAFALSRGVQRGSLDRHYAKVAKRAYDGVLQRISLGSDGRTHLTDI
                     TIGTNVGDYDYYIDRTRATNDFHGLGAFLIMSEQLRAR"
     gene            complement(10001..11152)
                     /gene="pqqE"
                     /locus_tag="KI385_RS02050"
                     /old_locus_tag="KI385_02050"
     CDS             complement(10001..11152)
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645347.1"
                     /locus_tag="KI385_RS02050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02050"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_238577539.1"
                     /sec_met_domain="PF04055 (E-value: 1.8e-24, bitscore: 86.0,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2.7e-06, bitscore: 26.7,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 4.4e-06, bitscore: 26.1,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 2.3e-08, bitscore:
                     33.2, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGTSSPSGARARSRPWALLAELTHGCPLHCPYCSNPLELTRRSA
                     ELTTDEWREALRQAADLGVVSAHLSGGEPLLRSDLEAIVAAADGAGIHTQLITSGVGLS
                     RARLGRLVDAGLRSVQLSVQHADPSAADLIAGRRSFVDKERAAALVRDSGLPLGLNVVL
                     HRHNLDALDELIDLAPAWGADRIELANTQFYGWALRNRAELLPSREQLTRAQQTVRRRR
                     DELAGTVELVWVVPDYFDGNAKPCMGGWGAISLTIAPDGTTLPCPAAASIPGLDAPNVR
                     DHRLEWIWDHSRAFTLYRGTEWMRDPCRSCELREKDFGGCRCQAFALTGDAAATDPACR
                     LSPDHALVRDLVDASPEPPAAGLGRPRSPARRAAVTPRGAAGT"
     gene            complement(11175..11432)
                     /gene="pqqD"
                     /locus_tag="KI385_RS02055"
                     /old_locus_tag="KI385_02055"
     CDS             complement(11175..11432)
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016433952.1"
                     /locus_tag="KI385_RS02055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02055"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_238570517.1"
                     /sec_met_domain="PqqD_RRE (E-value: 3.6e-20, bitscore:
                     70.5, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 4e-09, bitscore: 35.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGWRPVLAPAVHLRHDRVRDTDVLLLPERVVVLEGNAGAVLRLC
                     DGQREVPDIVAELARLHPGAPVAEDVPEFLGRIREEGWLR"
     aSDomain        complement(11181..11420)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_KI385_RS02055_PqqD_RRE.1"
                     /evalue="1.20E-22"
                     /identifier="RREFam006.1"
                     /label="KI385_RS02055"
                     /locus_tag="KI385_RS02055"
                     /protein_end="84"
                     /protein_start="4"
                     /score="70.5"
                     /tool="antismash"
                     /translation="RPVLAPAVHLRHDRVRDTDVLLLPERVVVLEGNAGAVLRLCDGQR
                     EVPDIVAELARLHPGAPVAEDVPEFLGRIREEGWL"
     gene            complement(11429..12106)
                     /gene="pqqC"
                     /locus_tag="KI385_RS02060"
                     /old_locus_tag="KI385_02060"
     CDS             complement(11429..12106)
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056908.1"
                     /locus_tag="KI385_RS02060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02060"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_238570518.1"
                     /sec_met_domain="TIGR02111 (E-value: 2.3e-83, bitscore:
                     278.2, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTPFEERLRAVARDSYHDRHPFNIRMHEGTLTQEELRRWIRNRF
                     HYQRHIPVKDALIVAKLRTPELRRMWLRRIQDHDGQQDGEGGIERWLRLGEAAGVDRSL
                     LMDETGVLPGVRLAVDGYVNFCRLRSPLEAVAASLTELSAPDIMRTRIDAFETHYGWIE
                     AEGLSYFRGRQSQGRRDSKEALALVLDWARTEAEQDQAVAALTFKCQVLWALLDAVERG
                     ERP"
     gene            complement(12103..13110)
                     /gene="pqqB"
                     /locus_tag="KI385_RS02065"
                     /old_locus_tag="KI385_02065"
     CDS             complement(12103..13110)
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669247.1"
                     /locus_tag="KI385_RS02065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02065"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_238570519.1"
                     /transl_table=11
                     /translation="MLLQVLGTAAGGGVPQWNCACPGCSGARTHPDRRRRHASLAVRAD
                     DDHWYLINATPDIADQIESTPALHPGPAARRTPVAGLVLTDAELDHTLGIARLREADRI
                     EVLATGPVRAALRDRAHLDDILTPYVTLEWRELGSVPVPLGQGSDIEISVIPVSAKRPR
                     YAAPRASRTSGSGEGADSGEGADSGERRDFGREADHEGQAEKPLGVEPWVVALRLHDRR
                     TGGTALYAPALAAWPDAFQEALADADCVLLDGTFWDDDEPRRSGFSTRTATEMGHLPID
                     GPDGTAGRLAPLAARCLYTHLNNTNPLVDPAAPQHKQLADLGLAVAAEGMEIAL"
     gene            complement(13121..>13198)
                     /gene="pqqA"
                     /locus_tag="KI385_RS02070"
                     /old_locus_tag="KI385_02070"
                     /pseudo=""
     CDS             complement(13121..>13198)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_093467075.1"
                     /locus_tag="KI385_RS02070"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02070"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /pseudo=""
                     /transl_table=11
                     /translation="SAWQTPGYTVIETALEVTAYSLNAR"
     gene            14036..15133
                     /locus_tag="KI385_RS02075"
                     /old_locus_tag="KI385_02075"
     CDS             14036..15133
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712691.1"
                     /locus_tag="KI385_RS02075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02075"
                     /product="PQQ-dependent sugar dehydrogenase"
                     /protein_id="WP_238570520.1"
                     /transl_table=11
                     /translation="MRIRTRSARHTTLTVVAASALTAGLLLSAAGTGGAAGTTALASEP
                     GSPKTVSSGWSIPWGLSWLPDGSALITERDSFKVYTLAQDGTKKEIGTVPDVVSTGGEG
                     GLLSIAVSPSWKTDHHVYVMHTASEGNRIARMTFDGSTLGDYKVLVNSIKKNKYHNGGR
                     IKFGPDGYLYATTGEAQTPDLAQDKKSLNGKVLRMTPDGKPAPGNPFDSLVYSYGHRNP
                     QGITWDAQGRLWEGEFGDSKYDELNLIQPGKNYGWPKCEGKCSTSGMTNPKRQWPVEEA
                     SPSAVAYADGAIYMAALRGERLWRIPVNGTSTGTPKAYYTHDYGRLRTVESVPGKKSLW
                     LTTTNADNNGDGGPGSDKVFQIDLK"
     gene            15414..15953
                     /locus_tag="KI385_RS02080"
                     /old_locus_tag="KI385_02080"
     CDS             15414..15953
                     /EC_number="2.1.1.63"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003908 -
                     methylated-DNA-[protein]-cysteine S-methyltransferase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009719764.1"
                     /locus_tag="KI385_RS02080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02080"
                     /product="methylated-DNA--[protein]-cysteine
                     S-methyltransferase"
                     /protein_id="WP_238570521.1"
                     /transl_table=11
                     /translation="MSHPTTTTLTTSYTTLDSPLGELLLVGEESPTAPGGTALTSLSMP
                     HQRGAATVQPHWRRDPRPFTEAVRQLRAYFTGELTRFDLEYRTSGTEFQERVWQALEAV
                     PYGTTTTYGRLAEALGVRRAEVRALGAAIGANPLLILRPCHRVIGADGTMRGYAAGVER
                     KTALLTHEGALQPTLV"
     gene            15963..16574
                     /locus_tag="KI385_RS02085"
                     /old_locus_tag="KI385_02085"
     CDS             15963..16574
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009719760.1"
                     /locus_tag="KI385_RS02085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02085"
                     /product="hypothetical protein"
                     /protein_id="WP_238570522.1"
                     /transl_table=11
                     /translation="MPVKSLPSLPAPPPATSPLIPHGEAAAYGDLPSPDPHTDAELAAL
                     LRMLTAPPPTRIASVVVGHSRDAASCSAAAAFVEAWRAMGREVLAVIDWPEVAASWLRA
                     ANRFTAEEPDGWVVAAAPLGWAQMSRRLRHSTDWDPARTYGFASLGDSRIPALAGPATL
                     QGMRGATADGGSIWTIDRGWVTQRVPVPPTGDSPPVARCT"
     gene            16596..17351
                     /locus_tag="KI385_RS02090"
                     /old_locus_tag="KI385_02090"
     CDS             16596..17351
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006606899.1"
                     /locus_tag="KI385_RS02090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02090"
                     /product="alpha-ketoglutarate-dependent dioxygenase AlkB"
                     /protein_id="WP_238570523.1"
                     /transl_table=11
                     /translation="MSTPLPGFEGVGQPAGAGASDGTGGGLHTSSADRAGPHPGRLELA
                     PGAVHVPGWLTLAQQRELVTACRDWARGPAPIRHTKLPRGGVMSVQTVCIGWHWQPYAY
                     TRTADDVNGAQVAEFPDWMVELGRRALVTAYQDASAGDDYTPDTALINFYDGQAKLGMH
                     QDKEERSGAPVVSLSIGDTCTFRFGNSETRTKPYTDIELASGDLFVFGGPSRFAYHGVP
                     KVRPGTGDPATGLTSGRLNITMRVTGLDG"
     gene            17383..17667
                     /locus_tag="KI385_RS02095"
                     /old_locus_tag="KI385_02095"
     CDS             17383..17667
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017239079.1"
                     /locus_tag="KI385_RS02095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02095"
                     /product="DUF2277 domain-containing protein"
                     /protein_id="WP_238570524.1"
                     /transl_table=11
                     /translation="MCRSIKTLRPPTTPEVTDEDIRAAALQYVRKVSGFRAPAAHNHEV
                     FDHAVDAVAAATQELLAGLQIRGSAPLTIRPAPEPVGDRSETDRARSTY"
     gene            complement(17597..18451)
                     /locus_tag="KI385_RS02100"
                     /old_locus_tag="KI385_02100"
     CDS             complement(17597..18451)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006606897.1"
                     /locus_tag="KI385_RS02100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02100"
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="WP_238570525.1"
                     /transl_table=11
                     /translation="MAAAAIAGPAVAAAYGSGTAYAADGRRGLRVMTFNLRYASDTRPN
                     SWAERRPVMRALLRREAPQLLGTQEGLYGQVRDIAEDLGPHYDWVGTGRGGGSKDEFAT
                     VFYDVRRLAPVEYDHFWLSDTPYLIGSTTWGNTVIRMVTWARFRDVRTGGEFYALNTHL
                     DHANQYSRERSAALITERLRGLDPVLPRIVTGDFNVAAHKNPVYEAMLDGGSLVDSWDT
                     ADERSAQYATFHGYRPLVPDGDRIDWILTSPGVRTRRATINTYSAHGQFPSDHLPVQAL
                     VEW"
     misc_feature    complement(18281..18283)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(18799..19419)
                     /locus_tag="KI385_RS02105"
                     /old_locus_tag="KI385_02105"
     CDS             complement(18799..19419)
                     /EC_number="1.5.1.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016646 - oxidoreductase activity, acting
                     on the CH-NH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016574713.1"
                     /locus_tag="KI385_RS02105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02105"
                     /product="flavin reductase family protein"
                     /protein_id="WP_238570526.1"
                     /transl_table=11
                     /translation="MRIDFDPAAMSRNEFYKLLTAVVVPRPIAWVSTYDPYSDSANLAP
                     HSFFTIASVAPPVVQFSSVGRKDTLRNIEATGQFVVNFASEGQFEQINDTGTDFPHGVS
                     EFEAAGVESEPSLRVKPLRVAGSSVALECEVHTTIGIGDSTIVFGRVVHAVVSQDVLVD
                     GHPEISKLKPLSRLGKDEWGTVGDVREISRIRHADWRGPAGDR"
     misc_feature    complement(19386..19396)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     misc_feature    19417..19432
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.23"
                     /tool="antismash"
     gene            19541..20332
                     /locus_tag="KI385_RS02110"
                     /old_locus_tag="KI385_02110"
     CDS             19541..20332
                     /GO_function="GO:0000150 - DNA strand exchange activity
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012464.4"
                     /locus_tag="KI385_RS02110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02110"
                     /product="recombinase family protein"
                     /protein_id="WP_238570527.1"
                     /transl_table=11
                     /translation="MTTAVTVWEDFDVPAHARGGQVTLNLYDHLAAYAPKRPGAYLRIS
                     SDRFGLEAGVDRQLEDAEDSRTRLRWGPFAKVYRENDTSAFKKRKVIKADGSIDWIVLR
                     PEFRQLLADLAHGVIDGVIFYDLDRLVRQPRDLEDLIDIVEYVKRPVTGATGSRMNLIN
                     DSDRHMTRMMCVMALKSSEDTARRVAHQHLSAAQNGLTQGRIAYGWVRKGESKGKLVPD
                     EADVVVRIFQHFMSGESATASPRPSMPKESSRLPPIPGPRR"
     gene            20570..21661
                     /gene="corA"
                     /locus_tag="KI385_RS02115"
                     /old_locus_tag="KI385_02120"
     CDS             20570..21661
                     /GO_function="GO:0015087 - cobalt ion transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0015095 - magnesium ion transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006824 - cobalt ion transport [Evidence
                     IEA]"
                     /GO_process="GO:0015693 - magnesium ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="corA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006603180.1"
                     /locus_tag="KI385_RS02115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_02120"
                     /product="magnesium/cobalt transporter CorA"
                     /protein_id="WP_238570528.1"
                     /transl_table=11
                     /translation="MIHNLRKAVHIPSTRPHGVDLSHPARSPLGNCVVNCAVYVDGVRQ
                     VSHCPARKAIEQVRETGNGFVWIGLHEPAEEEFSEIGELFGLHPLAVEDAVDAHQRPKL
                     ERYNDTLFTVLKTVTYVEHDRLTATSEVVDTGEIMVFTGPDFVITVRHGGHGSLGPLRE
                     SLESTPAHLAKGPSAVLHAVADHVVDDYLAVISAVQDDIDAVESEVFSDHRGRGVDAGR
                     IYQLKRELLELKHAVVPLDRPIQLLAEQPTQLVDADIRKYFRDVADHLARVNEHVTACD
                     ELLNSILEANVAQVSMAQNEDMRKISAWVAIIAVPTMVCGVYGMNFEYMPELRWTFGYP
                     LVLAGMATACFLMYRGFRRNGWL"
     gene            complement(21736..22011)
                     /locus_tag="KI385_RS02120"
                     /old_locus_tag="KI385_02125"
     CDS             complement(21736..22011)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KI385_RS02120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KI385_02125"
                     /product="hypothetical protein"
                     /protein_id="WP_238570529.1"
                     /transl_table=11
                     /translation="MNDHDLTRERRAVWFAARCLAEEAPALTAASAGALRAGLAARFAT
                     LRRAALAASRAGVPPRAIAQDSGLPPATVLQWIAEDRRSHLTANSG"
ORIGIN
        1 aaacgcaacg tgagatcgca cgctgggcgg cccggcgcgc gtacaccctc gcgggcctgg
       61 cggacgtcga ctggatcgca cccgccctgc acgccctcga tgtgggacgc cggctgcccc
      121 cgccgttcga cgactgggac gacgtatggg agcggctgtt cagcgatcca cgggtaccgg
      181 cgacaaccgt gacgtccatg gacggcgcca ggaacaacat gtcacagcag gcgatggcga
      241 tcccggcgct gttcggcgcg gtggaggacg atccgctgca ggccgtcctg gacgcgctct
      301 acgcggcggc cgccgcattc ggcagcgcat accccgccct cttcgccgaa gtccggcgga
      361 ccttccccgg catagtgagc ccggcagcgt agagccggat gatgtctgtg cgagagtgat
      421 cagatgatga agacgatcgg cctgctcggc ggcatgagct gggaatccac cgcggagtac
      481 taccggctac tcaatcagct gacgcgtgac cggctgggcg gcctccactc atcccggtgt
      541 gtgctctact ccgtggactt cgcggagatc gaacagctcc aggtcgaagg acgctgggag
      601 caggctgccg aggtactcgc cgaggctgcc agggcgctgg agtcggccgg cgtggacatg
      661 ctgctgatct gcaccaacac catgcacaag gtcgccgacc aggtggccgc cgccgtcggc
      721 atcccgctgc tgcatctcgc cgacaccaca gccgatgccg tacgcgccaa cggcctccgc
      781 cgcatcggac tgctgggcac cgccttcacc atggagcagg acttctatcg cggccggctc
      841 gaaagccatg ggctggaggt gctcgtcccg gacgccgccg ggcgaagcac cgtccaccgc
      901 gtgatctacg aggagttgtg cctcggcatc gtccacgaag agtcccggaa gtcattcatg
      961 gccatcatcg gggagctcgt cgccgccgga gccgagggca tcgtgctggg ctgcacggag
     1021 atcgaactgc tcataggccc ggagcacagc ccggtcccgg tcttcccgac cacccgactg
     1081 cacgccgaag cggcggtcac gctcgcgctc accgacgttc cgtagtcgca gtcccccggc
     1141 cccgtttccg gcaacccgcc tcctgcaatc gtgcgatccg gccacccgcc ggaaacggtg
     1201 gccaccattc aactcccata tctccaccga tttttgggtc gtgcggaggt ttgaagtggc
     1261 gacgggtacg ctgacgtggt gtcgcgtagc gagttggaac gattggccag gatccggatg
     1321 caggtcaccg gggagtcgct cgaacgcgcc atggctgtgc tccaggggca tcccaccgac
     1381 tccggaccgg aacccgaacc ggagccggga cgggaacagg aactgggaca gggaccggga
     1441 ctgggacggg gactcgaacc cgagtcagca tccgaacccg atgagaacgg tgccgtcgac
     1501 gacaccggca cgagcagcga gggcagcgag gccgacgcta cgcccgcgga gcctgacgcc
     1561 cgcccgacgc ctcagcggcg gtcccacctg cgcggcctct gatcaccgtg cgcactccgc
     1621 cgtgatcacc gcgcacgctc cgtggccgcc gcactgccgc accgccgcag cggtggcacc
     1681 aggcgccatg tgcaccgcga cgcacagcgc acaaagggtt accgagaggc cccccgtttc
     1741 atcttggaca accgcgatcc gctcgtccgt tgacggcccg cccgagagca cggcgcaatc
     1801 ggtagacgac gcaacgtgat cgcgacagta cggcgggcag cgcacggcgg agcatgacgg
     1861 gcaggctgtc actcagtgag tgagccgtcg ggccagcatc ggcgtccggg gaacctgatg
     1921 tcccccgctg gccagcatgc ggacctcacc ccggtcactg atctcggcgc gcacgatccc
     1981 cgactcgtcc tcgtagaccg ggtacccgcc cgctcctgcc cgctcggtac gccggacgat
     2041 caccacgtcg tcctctaccg cgggagcttg aaataccagc tcatagcatt ccgggtaatc
     2101 ctccatcggg gcctcccgat acggctcggc aggtgccgga cgcccctccc ccgccgctgc
     2161 tgtgcgcgcc cgccgcacct cggcccttcc atcgtcgccc accctcggcc gccgcgcctc
     2221 aggaagacgc gggaacggct gttccccggc cggtgggacg cctccctgga gacctggctc
     2281 ccgtaaacct gacatttgtc atgcgtgctt gggatcaagg tcgttccacg ggttgatggc
     2341 tggtcgctgt tccaccgcaa gaatcgcaac agcgaagatc gaacaccggt cgcagaccat
     2401 caactcacgg agacaccatg cctgttaccc ctgcgcatcg ccgccgagtg cggctggccg
     2461 ggaccgccac agccgcctta ctcgcactga tggtcccgac cgccgcctct gctgcttcag
     2521 cgcccgccct gcctgccggg aatgccaccg cgatgcccgc cgaccgggcc gggctcgacc
     2581 gggccgcgct ggacgccacg ctcagggcat tccatgacgc ggggatgtac ggcgcctatt
     2641 cggcggtgcg ggacggcacc gagcagtggc agggcgccgc cggggtcgcc gacgtcgaca
     2701 ccggacgccc caccacgcca cagatgcggc accggatcgg cagcatcacc aagaccttca
     2761 cggcagccgc cgtccttcaa gaagtcggca aggggcacat cgagctggac gctccgatag
     2821 gccgctatct gcccgatctc gtcccagggg agcgtggccg cgcgatcacg gtccggatgc
     2881 tgctcaacca caccagcggg atcggtgact acggcggggc gatctttgcg acgcccgaga
     2941 gcctggaggg caaccgcttc caccagttcg accccaggga gctggcccga ctcggcctga
     3001 aggcaaggcc gttgggcagt cctggccagg ctcaccacta ttccaacacc aattacgtga
     3061 tcgcggggct cctgctgcag aggatcaccg gcgagtcccc cgagacctac atcaccgagc
     3121 acgtcatccg gaaggcaggt ctgcagcaca cctacttccc gcgatcggcg tacatcaccg
     3181 gaccgcacgc caagatgtac gaggctgcct acggcgactt caacccgccg cgcgatttca
     3241 gcgtctacaa cctgtcctgg gccgggacgg cgggttcgct cgtgtcgacg atggccgatc
     3301 tcaatcgctt ctaccgcgca ctgttgcatg gtcacctcct cgcgccggcc cagctgcggc
     3361 agatgaaaac cacggtgccg atggaaggca gtgcggtccg ctacggcctg ggcctgggcc
     3421 tgttcaaaat ggccttgccg tgcggggagt tctgggggca cgacggcctt gtgcccgggg
     3481 cgatgacgtg gtcactgtcc actgcggacg gccggcgtca gatatccctc ggctataatc
     3541 tgacgcacta tcagaagctc gacagcaacg accgccccaa ggccggtccg atagacgccg
     3601 ccatggacac acacctcgtg caggcactgt gcggtacgag cggcagcctg cgagcgggac
     3661 atccgggcac gtccggcacg ctccccctcc acacctctcc gcaggagcct tcgctcgctg
     3721 tgcaccacca gtgaacgttc ggcggatcgc caggtcgggc cggggacgac ctaggcccgt
     3781 tcaccacccg gcttgtgccc cgctcccgtg cgctgtcaca ggagcggggc gggtccgagt
     3841 agcgccagca gctcggatag ttacaagaac caccgtacgg gtcaccactg acaacggagg
     3901 ggcctgaggg cacagtggtg cgctcgggga ggggcctggg ccactggaat cggtggaagc
     3961 cagggaccga agacgtcacc cgatagaggt agcgccctgc gggtgctgcg aagggagcga
     4021 tggcagtggc cgggagacct cggttctcac ttgcgacggt ggtcgtggat tgtccggatg
     4081 ctcaggcgct tgcggatttc taccggcggc ttctggggtg ggaggtgaaa ttcagcgagc
     4141 ccgactgggt gctgctcaga tgcccggacg ggggtacggg gctctcgttc cagtcggagc
     4201 ccgagtatcg ggccccggtg tggccggaac ggcccgagga gcagcagaag atgctgcatc
     4261 tcgatatctg ggtcgatgac cttgtagagg ccgaggcgta tgcggtctcg gtgggcgcga
     4321 ggcgagccga attccagccg caggatgatg ttcgggtgtt ctttgatccc gctggacatc
     4381 ccttctgcct gttcctccat tgatgagcgg aacctgccta ctgatgatgc ggccaccgca
     4441 tggtcggcgg gcgggtgatc gcggaacgtg tgggaatgga cacatgcaga cagcaggcgg
     4501 agagcgaaag gccgacggtc tttgctggtc agggagttga ggcggggtgg cgggccccag
     4561 cagtgacggg ggcggagagc ttggggccgg cgcacgcggg gctctgttgt cagtgggtgc
     4621 ccctagcatg gttcatatgt ccccaactcc ttctgcccat acgggtgcgc ccgttcctgc
     4681 ttccgaggcg aacgaatcga tccggcgatt tgtgcgcgcc cggcgcgact tggcgtggac
     4741 gcctcaggac atggcggagt atgcggtgct gctggagatc tggacaatgg cggtgcgctc
     4801 ggaggttacg gaagtagttg aggcggcgta gcctccgtac ctcgtcggca acatctgatg
     4861 aataacccgc aaggaagcct gagttaacgg cgttgcgtga gtggtgcggc cgctagtgat
     4921 gtggcgttag cggtcgtgcc tcggtgagcg tacgtcgcgg cggcagcgcc atccccaatt
     4981 accgcttcag cccaggtact tggcgacaat cttcgtgtac gcatagggat cctgggacac
     5041 cccgctgcaa ctgtcgccgt cgctgccgga gccgcacggg cgatcgcggt tgaccgacca
     5101 gaacgcgaaa cgagcgatgt ggtgctgctg ggcgtagccc aggatcgtac ggaagtcggc
     5161 gagggtgacg gtctcgtcgg cgtcatcggt cttgccgttc atcgacgaga cgccgatgtg
     5221 gcggtaggcg tccgcgtcac cgtagccgta agagttcttg accgcggcct tgaggccttc
     5281 cagcgcgctg acggtggcct ggcccatggt gccgctgtgg ccgccgaagt cgaacggcat
     5341 cacgacccag ccgtcattgt ccagtccggc cgccgcgccc ttcttgatga ggtccttgcc
     5401 gttgctgtcg gggccgttgg gggtggtgcc catggtgagg taggtgatga tgccggggtt
     5461 cttggccttg acgatcttca gggcgtcgat gacgcgcttg cggaccgtgg cattggtgaa
     5521 ctcggtgttc tcgatatcga cgtcgagcgc cttgagacgg tacgcgtcga tcaccttctg
     5581 gtaggccccg gcaagcgcgg aggcgctgcc gcacttctca ccgagcttgg caccgctcca
     5641 accaccgacg gagacgacca cgtccccgcc cttggcacgg atggatttga tggccgactc
     5701 atcgctgccg ccggtcagtg cccggctgcc gtcccacttc ggattgcagc caccgtcgga
     5761 gaggataaag gccagggtga atgttttggt gccggtcgcc gccatgacgt cggtgggagt
     5821 ctggggattt ccccagccca ggtattcgta gggcgcggcg gccatcggga cgaccgcccg
     5881 gggtgtggcg gcggcgccgt ccgcccccat ggccgccgcg gcgccgagca gcaagaggga
     5941 gagcgcgatc ggcagggatc gcgaacggtg gggctggttc atcgggtcac cactttccat
     6001 gtgttgtgtc gataccgtct ccggccaccg gccaccggcc accagtcact gctcaccggc
     6061 caccacccga caccggcgcc gcataccgcg tcccgaccca ggtctcgtcc acacggagcc
     6121 gccggtagcg cgtcgcgtcg gaggcggccg cgtacgtgct gcggacctcc agccgtacgt
     6181 aacgggtggt cgtggttgcg gggagatcga taaagctgac ggcgcggtgg ctcggaaggg
     6241 tgccggtctt cacggggctc ccccagtggg taccgtcctc gctcgcatac acgcggtact
     6301 ccttgatccg ggcggactgt tcggtgtccg agcgggcgta actgaccgag tcctcacgct
     6361 ggttgatgcc gaggtagcgc acgctccggt cggcgccgag agcgtacgtc agggagacgg
     6421 ggagggtgcg gtcgttgtcc cagtacgtga ggtggtcgcc gtccccggcc gccgaggcgg
     6481 ggtggccgtc ggcggcggcg ctggcgctca tcgtgtagga ggtggcgggc aggatccctt
     6541 ggcgtccggc ggtggtgacc ttgaagacgg tgtcgtacgg gtcccagtcg cccaggcccg
     6601 agagcgtcag gctgccgccg gactgggtga aggggatccg cgcgccggtc cgcaggtcgg
     6661 tcacctcggc cacccggtat ccgttgtcgc ggaggcggag ggtggatgtc gagggtgggg
     6721 tgatgacatg gacgtagtgg cggttggggt cggtggtgct gagggtggtg acaccgtgcg
     6781 catcgtcgtt ccagaagccg ggcgcgagac cgccatggag atagccgccg ccttcggttc
     6841 cgcgcaggga ctcccagatt ccgtccagat agccgtcggc gaaattgttg aaggcttcct
     6901 gtttcgccgg gaagcgcccg ttgacctgcg cagtctcggc catcagggcc ttgatggagg
     6961 aacctgcgtt ggtgatcaga cggccgaggg tgagcctgcg gtcgacggcc gggtcggatc
     7021 cgtcgtacca ccaggcgccg ctggagggga gtttgaagtc cgcctcggtc agccggggag
     7081 ctgcggtgta ggtcgcctgg gggtagtcgt acgagggaga catgccggtc ttctgctcat
     7141 tgctgatcat gtccatgacc gaagtgtcct cattgttgtt gctgagggtg tagcgggggc
     7201 gtagccggta gatccgctcg tagaggtgat ggtcgagcca gtagtcgttg tcgttgtcga
     7261 tccagaagcc gcccagctcg gggtagcgct ccatgacctc gaagaagttc tcgtacgaga
     7321 attccccgaa gccgtcgcgg gtggtcagat cgacattccg gcccttgtag cgggagtagc
     7381 cgtccgagtc gagccattca tggccgccgt cgttgtgcca ctgtggatcg tcggtcatat
     7441 agaggatgac tttcaggcct tttgccttgg ccgcggtgat cagctcgccg aggaagtccc
     7501 gtcgggtgtg gcagctgccc ggtattttcg acggccatga cctggcatag ccgagcctgc
     7561 tgtgaaagga agccagtacg agatactgcg catgcagctt tccggcctcc ttcacccaat
     7621 agtcggggct ccagccaccc gcggtgacgt ccttctccca gccactgcaa ctggtgtgct
     7681 gcggcgcggt ccgctcgccc cagtgaagga acagtccgga gaccgaaccg cgcagaaagt
     7741 tctgccgcgg gtgctgcaga tcggcgtatg cggtgccggg cagcgccagc gcgcccagca
     7801 gcagcgccag tacggccagg accaccgcgt aggcccgcat acgccgaccg ggcctcgcac
     7861 ctcggccggc catagcgccc cgcccggcca tcgcgcactc agtcatcgcg cgtctggtca
     7921 tcgcgcgcct ccgactgccc gcgctctcgg gaatccaagg tcgtacgggc gcttgccgcc
     7981 acgctgcgcg gtgaagtgat cgaacgtcag cttgtgcgcg acatgggcga tgacggcggg
     8041 ccggccgtca tcggcggcga agcgcaccga actgtcacgg acggtgatgc catcgacatt
     8101 gcggaggtac caaccgaagg ccgggcgggt accgatcttc cgcatgatgg gcgagtggac
     8161 gttcttcatg gtgatgtcgc ggtagtggac atcggggatc ttcgccccgt ccatcgacac
     8221 catgccgagc ccggacttat cggcgccgac gatggcgatc cggtcgaagt gacagtccgt
     8281 gaaatcgcca caggtctccg agccgaacat cagcgcattg ccgcacttcg cggagcgtcg
     8341 tgaatcacgc accgccacat gcccgttggg gagcttggcg cccagcgcgt aatcgctctt
     8401 gaagaccagc gcatcgtcgt tggcgttcgg tgccggtgcg tcgtacgtgt ccgcgccgga
     8461 gtcattggcc gagccgttgc cggccgcgcc gtggtccttg acgttgaatt cccgtagggc
     8521 ggtgcggccg gcctgccgct cccgtgcggc ggaatcgtcg gccttcccgg tgcgtacggc
     8581 agcccctgtg gaacgggtcc tcgccacgga cggctgtccg actccgaggg cgaccgcagc
     8641 ggccagggcg gcaccgactg cccatctctt ccccatcctc accttccgtg tcacctcgcc
     8701 cgcaactgtt cggacatgat caggaaggcc cccaggccat ggaagtcgtt ggtggcccgg
     8761 gtgcggtcga tgtagtagtc gtagtcgccg acattggtgc cgatggtgat gtcggtgaga
     8821 tgggtgcgcc cgtcactgcc gagcgagatc cgctgcagta cgccgtcata cgcccttttg
     8881 gcgaccttcg cgtaatgccg gtcgagagag ccccgctgca cgccgcggga gagcgcaaag
     8941 gcgaacatgc tggagcagga ggtctcggtc cagttgtcgg gtcgttcgcc cttgtccatg
     9001 acctggaacc agcgtccgct cgacggatcc tgggtcttct ccaggccgct tgcgagcttg
     9061 cgcagaattc cggtgagctg ggcacggcgc gggtgatcgg cgggcagcgc gtccagcacc
     9121 gtgacatcgg ccatggcgta ccagccgacc gcgcggcacc agtgctcggg cgcctgtccg
     9181 gttttcgtgt cggcccagtc ggcggtcttg gcttcgtcgt aggcgtgcct cagcaatccg
     9241 ctcgaatgct gcaagtgtcc gccgtatacc gcgagttgcc cggcggcctc gtcatcggcg
     9301 tacgccgagt ccccgaattc cttgccgtat tccacgagga acggcgtgac catatacacc
     9361 ccgtcggccc acagctgatg cgcccggctg ctcgatgtgg catgccagaa gccgccgtcc
     9421 gcggtgcgcg gatagctgtc gaggcgctta cggattttct gtgcggcgat ctggtagcgg
     9481 tgtgcaccgg tctcgtggtg caggatgacc agaagccgcc ccgcctgcat gctgtcgagg
     9541 ctgttgaagc tctggtcgat gttgccgttg ctgtcgacga accggtcgac gtactgcttg
     9601 atgtagtcga gatagcgctg ctggtgggtg cgttggtaga cgaggtactg gccgtagagg
     9661 tagaggccta cggggtagga ccagccgccg atcttgtccg gggtgtaacg ggcgagggtg
     9721 gagtcgacca gggctgtgga ccagtcggtg gcggagcggt cggggctcgg gcggcccaat
     9781 gcgctggtgt cggcgtttgt gtaactgcgg gcggcatggg tgcgcgcgcc ggcgacggtt
     9841 gcggcgtcac ctgcatcacc tgcatcacct gcatcgacga tggcctcacc gcgcgctgaa
     9901 cctgccgcgg gctccgtacc gttgggcacc gcaagcgccg tacagaccag cgccgcacac
     9961 gacagcaagg cggccgccag cactccacgg actctgacgc tcatgttcct gccgctcctc
    10021 tcggggtcac cgcggcgcgt cgggcggggc tacgcggccg gccgagtcca gcggccggcg
    10081 gctcgggtga ggcgtccacc aggtcgcgta cgagggcgtg atccggcgac agccgacagg
    10141 cgggatcggt ggccgcggca tcgccggtga gcgcaaatgc ctggcagcgg cagccgccga
    10201 agtccttctc gcgcagctca cagctacggc agggatcgcg catccactcc gtgccccggt
    10261 agagcgtgaa ggcgcgggaa tggtcccaga tccactccag gcggtggtcg cggacgttgg
    10321 gggcatcgag accggggatc gaggcggccg ccgggcaggg cagggtcgtg ccgtcggggg
    10381 cgatggtgag cgagatggca ccccaaccgc ccatacaggg cttggcgttg ccgtcgaagt
    10441 agtcggggac gacccagacc agttcgaccg tgccggccag ctcgtcacgt cggcgacgta
    10501 cggtctgctg cgcgcgggtg agctgctcac gggacggcag cagctcggca cggttgcgca
    10561 acgcccagcc gtagaactgg gtgttggcga gttctatgcg gtccgcgccc caggccggcg
    10621 cgagatcgat cagctcgtcc agcgcatcga gattgtgccg gtgcagcacg acattgaggc
    10681 cgagcggcag tccggagtcc cggaccagcg cggcggcccg ttccttgtcg acgaacgaac
    10741 ggcgtccggc gatcagatcg gcggcgctcg gatcggcgtg ctggacggag agctgcacgc
    10801 tgcgcagtcc ggcgtcgacc agccggccga gtcgcgcccg gctgaggccg acgccgctgg
    10861 tgatgagctg ggtatggatc ccggcaccgt cggcggccgc gacgatcgcc tccaggtcgg
    10921 agcgcagcag cggctcacca cccgagagat gcgcgctgac gaccccgaga tcggcggcct
    10981 ggcgcaatgc ctcccgccac tcgtccgtcg tcaactccgc cgatctacgg gtgagttcca
    11041 gcggattgga gcagtacggg cagtgcagcg ggcagccgtg ggtgagctcg gccagcaggg
    11101 cccaggggcg ggaccgggcc cgggccccgg acggggagga cgttccggtc atcgcagcca
    11161 tgaacgtatt ccggtcatcg cagccatcct tcttctcgta tccgcccgag gaattccggt
    11221 acgtcctccg ccaccggagc gcccgggtgg agacgggcca actccgccac gatgtcgggc
    11281 acttcgcgct gcccgtcaca cagccgcagt acggcgccgg cgttcccttc cagcaccacc
    11341 acgcgttcgg gcaggagcag aacatcggtg tcgcgcaccc ggtcgtgacg cagatggacg
    11401 gcgggggcga gtaccgggcg ccagcccgtc atggccgctc cccgcgctcg accgcgtcca
    11461 gcagtgccca cagcacctgg catttgaacg tcagcgcggc gaccgcctga tcctgctcgg
    11521 cctccgtacg cgcccagtcc aggaccagcg ccagagcttc cttgctgtcc cgacggccct
    11581 ggctctgccg gccgcggaag tagctgagcc cttcggcttc gatccagccg tagtgcgtct
    11641 cgaaggcgtc gatccgggtg cgcatgatgt ccggtgccga cagttcggtg agcgaggcgg
    11701 cgaccgcctc cagcggtgag cgcagccggc agaagttgac atagccatcc accgcgagcc
    11761 gtacgcccgg cagcacgccg gtctcgtcca tcagcaacga ccggtccacc ccggccgcct
    11821 cgccgagccg cagccagcgt tcgataccgc cctcgccgtc ctgctgcccg tcatggtcct
    11881 ggatccggcg cagccacatc cggcgcagtt ccggggtacg cagcttcgcc acgatcaagg
    11941 cgtccttgac ggggatatgg cgctggtagt ggaaccggtt gcggatccag cgacgcagct
    12001 cctcctgggt caacgtccct tcatgcatac ggatgttgaa cgggtgacgg tcgtggtagc
    12061 tgtcgcgcgc cacggcccgc agccgttcct cgaacggcgt gctcataggg cgatctccat
    12121 cccttccgcc gccaccgcga gccccaggtc cgccagctgc ttgtgctgcg gcgcggcggg
    12181 gtcgacgagc gggttggtgt tgttgaggtg ggtatagagg cagcgggcgg cgagcggcgc
    12241 cagccggccg gcggtgccgt ccggcccatc gatgggcaga tggcccatct cggtcgcggt
    12301 acgggtggag aagccgctgc gacgcggctc gtcgtcgtcc cagaaagtgc cgtcgagcag
    12361 tacgcagtcg gcgtcggcca gcgcctcctg gaacgcgtcg ggccaggcgg cgagggcggg
    12421 ggcgtagagc gcggtgccgc cggtacgtcg gtcgtgcagc cggagggcga ccacccaggg
    12481 ctcgactccg aggggcttct ccgcttgccc ctcgtgatcc gcttccctgc cgaagtccct
    12541 tctctcgccg gaatccgctc cctctccgga atctgctccc tcgccggaac ccgaggttcg
    12601 actcgcgcgt ggagccgcgt accggggccg cttggcagag accgggatga cgctgatctc
    12661 gatatcggat ccttggccca gcggcacggg tacggacccc aactcccgcc attccagggt
    12721 gacgtagggc gtaaggatgt cgtcgaggtg cgcacggtcg cgtagcgccg cacgaaccgg
    12781 tccggtggcg agcacctcga tccggtcggc ctcgcggagc cgtgcgatgc cgagggtgtg
    12841 gtcgagttcg gcgtcggtga gcaccagtcc cgccacgggg gtacggcgtg ccgcggggcc
    12901 cgggtgcagg gcgggggtgc tctctatctg gtcggcgatg tcgggggtgg cgttgatcag
    12961 ataccagtgg tcgtcgtcgg ctcgtacggc gagcgaggca tggcggcggc gccggtcggg
    13021 atgggtgcgt gccccggaac acccggggca cgcacagttc cactggggca ctccgccacc
    13081 cgccgcggtg ccgagcacct gcagcagcat ggcggggcgg tcagcgggcg ttgagcgagt
    13141 aggcggtgac ttcgagcgcg gtctcgatca ccgtgtaacc cggcgtctgc caggcggacg
    13201 gctcacggtg cgaggccgcg ggccgggcgg tgaccgcggt ctgcggcgtc cccggagcct
    13261 ccgaggtctc tcgcggagcg ccttgcacac gggacgtcac acgggaggcc atgccggaat
    13321 tcatgggcgg agtcatgggg cgattcatgg ggagattcat gcgggatcca gcctttcgta
    13381 tgggggtgaa gggcgagaag gtgtggagat gtgaggccag cgctccgggc gtgaggccat
    13441 tgtcgaccga cagcttgagg gcatggcgga ccgacctatg acctcgccag ggcaccattg
    13501 ccactactcg cacggagagg ggaggcgcgc aagaacgccg gtccggccac caacggcccc
    13561 agggcgccgg acgttggcgg atcgtcgacc acgttggaca tgtgttcgtc gtgttgcttc
    13621 gcgtgacgtc acgttacttc gcgtggcgac gtgttgcgcc gcgccaggtt gctgctttgc
    13681 caggttgctg ccttgcagaa tcctcagcca cagggtcgcg gtcaatgggc gggacgaaaa
    13741 atggtccgac ctatggggcg gttgcgcagc tgtccaggcg ccccaacatc cgcaatcctc
    13801 ctgctcaata ggggtgaccg cagaatgcac acaccaccta aagatctttt ggcaccaact
    13861 ccccctacag ggacgggaga tacctcctac cttcctgcca cttgaccccc atcctgaggc
    13921 gcagtagttt tccggcccga accaacagga aactttccta tcagcccggc gccgctgatg
    13981 gttgctcacc cccgagggaa cgccccgtcg catcttcctg accggaggac cccccatgcg
    14041 cattcgcacc cgatccgcgc gccacaccac attgaccgtg gtcgccgcct ccgccctgac
    14101 cgccggactt ctcctctcgg ccgccggtac gggcggcgcc gccggcacca ccgccctcgc
    14161 ctccgagccc ggctctccca agaccgtctc gtcgggctgg tccatcccct ggggcctgag
    14221 ctggctgccg gacggctccg ccctgatcac cgagcgggac tcgttcaagg tctacacgct
    14281 cgcccaggac ggcacgaaga aggagatcgg cacggtcccc gacgtcgtct ccacgggcgg
    14341 cgagggcgga ctgctcagca tcgccgtttc gccgtcgtgg aagaccgacc accatgtgta
    14401 cgtgatgcac accgcctccg aaggcaaccg catcgcgcgc atgaccttcg acggcagcac
    14461 gctcggcgac tacaaggtgc tggtcaacag catcaagaag aacaagtacc acaatggcgg
    14521 gcgcatcaaa ttcggccccg acggctacct gtacgccaca acgggcgagg cccagacccc
    14581 cgatctggcc caggacaaga agtccctcaa cggcaaggtc ctccgcatga cccccgacgg
    14641 caagccggcc cccggcaacc ccttcgactc gctggtctac tcctacgggc accgcaaccc
    14701 gcaaggcatc acctgggacg cccaaggccg cctgtgggaa ggcgagttcg gcgacagcaa
    14761 gtacgacgag ctgaatctca tccagcccgg caagaactac ggctggccca agtgcgaggg
    14821 caagtgctcc acctcgggaa tgaccaaccc caagcgccag tggccggtcg aggaggcctc
    14881 acccagcgcg gtcgcctacg ccgacggggc gatctacatg gcagcgctgc gcggcgaacg
    14941 cctctggcgc attcccgtca acggcaccag cacgggcacc cccaaggcct actacaccca
    15001 cgactacggg cggctgcgta ccgtcgaatc cgtacccggc aagaagtccc tgtggctgac
    15061 caccaccaac gccgacaaca acggcgatgg cggacccggc tcggacaagg tgttccagat
    15121 cgacctcaag tagctcctgg atcgagacca gcacgtcgaa ccgtcgcccg cctactgggc
    15181 aacggttcga cgcggcagtg gccgaatgcc gacagacgac aggccccaag cgacgagcca
    15241 cgggcgacag ccggcaggca accgcgacgt ccgatttccg ccagcccgag cgtcctcgaa
    15301 cccacagact cgaagaacag aagcgcaaag cgccaacaag cactgcgaac gaccagtacg
    15361 aacgcgggct gcgaacgacc agtacgaacg cggactacga acgaggacgc accatgagcc
    15421 accccacgac aaccaccctg accaccagct acaccaccct cgacagcccc ctgggcgagc
    15481 tgctgctcgt cggcgaggaa tcgcccaccg cccccggcgg cactgccctg acctccctct
    15541 ccatgcccca ccagcggggc gcggccaccg tccagccgca ctggcggcgc gacccccgcc
    15601 ccttcaccga agccgtccgg cagctccgcg cctacttcac cggcgagctc acccgcttcg
    15661 acctcgagta ccgcacctcg ggtacggagt tccaggagcg cgtctggcag gccctggagg
    15721 ccgtcccgta cggcaccacg accacctacg gccggctcgc cgaggccctc ggcgtccgac
    15781 gggccgaggt acgggcactg ggagccgcga tcggcgcgaa tcccctgctg atcctgcgcc
    15841 cctgccaccg tgtgatcggc gcggacggca cgatgcgcgg ctacgcggcg ggcgtcgagc
    15901 gcaagaccgc gctgctgacg cacgagggcg ccctccagcc cacactcgtc tgagcccggc
    15961 ccatgcccgt caagtctctc ccctctctcc ccgcccctcc cccggcgacc tctcccctca
    16021 ttccccatgg ggaggcagcc gcgtacggcg acctcccctc ccccgatccg cacaccgatg
    16081 ccgaactcgc cgcgctacta cgtatgttga ctgcgccgcc ccctacccgc atcgcctcgg
    16141 tggtcgtcgg gcacagccgg gacgcggcgt cgtgttccgc cgcggcggcg ttcgtcgagg
    16201 cgtggcgtgc catgggccgg gaggtcctcg ccgtgatcga ctggccggag gtcgccgcgt
    16261 cctggctacg ggcggccaac cggttcaccg ccgaggagcc ggacggctgg gtggtggccg
    16321 ccgcaccact cggctgggcc cagatgagcc gccgtttgcg ccacagcacc gactgggacc
    16381 cggctcgcac ctacggcttc gcttctctcg gcgactcccg tatccccgcc ctggcaggcc
    16441 cggcgacact gcagggcatg cggggcgcca cagcggacgg cggcagcatc tggacgatag
    16501 accgcggctg ggtcacccag cgggtaccgg tcccgccgac cggcgactca ccgcccgtgg
    16561 cacgctgtac ataggtaccg atgaggcagg agcagatgag cacgccactt cccggcttcg
    16621 agggcgtcgg gcagcctgcg ggtgccggag catccgacgg caccggcgga ggcctccaca
    16681 cctcatcggc cgaccgggcc ggtccccacc cgggccgcct ggaactcgcc cccggcgccg
    16741 tccacgtccc cggctggctg accctggcac aacagcgcga gctcgtcacc gcctgccgtg
    16801 actgggcacg cggcccggcc ccgatccggc acaccaagct cccacgcggt ggcgtgatgt
    16861 ccgtccaaac ggtgtgcatc ggctggcact ggcagccgta cgcatacacc cgtaccgccg
    16921 acgacgtgaa cggcgcacaa gtcgccgaat tccctgactg gatggtcgag ttgggccgcc
    16981 gggccctggt caccgcgtat caggacgcat ccgcgggcga cgactacaca ccggacaccg
    17041 cactgatcaa cttctacgac ggccaggcga aactcggcat gcaccaggac aaggaagagc
    17101 gctccggcgc accggtcgtc tccctcagca tcggcgacac ctgcaccttc cgcttcggca
    17161 acagcgagac ccgcaccaag ccgtacaccg acatcgagct ggcgtccggc gatctcttcg
    17221 tcttcggcgg gccgtcccgc ttcgcgtacc acggggtacc caaggtccgc cccggcaccg
    17281 gagacccggc gaccggcctg accagcggcc gcctcaacat cacgatgcgg gtgaccggac
    17341 tcgacggata gctccgccac gcgagagagg cagactggac tcatgtgccg cagcatcaag
    17401 acgctccgtc cgcccaccac ccccgaggtc accgacgagg acatccgggc cgccgccttg
    17461 cagtacgtcc gcaaggtctc cggattccgc gccccggccg cgcacaacca cgaggtgttc
    17521 gatcacgccg tggacgccgt ggcggccgcg acccaggaac tcctcgccgg cctccagatc
    17581 cgcggctcgg ctcccctcac cattcgacca gcgcctgaac cggtaggtga tcgctcggaa
    17641 actgaccgtg cgcggagtac gtattgatcg tggcgcgccg cgtacgcacc cccggcgagg
    17701 tgaggatcca gtcgatccgg tccccgtccg gcaccagcgg ccggtatccg tgaaaggtgg
    17761 cgtactgcgc gctgcgctcg tcggccgtgt cccagctgtc gacgagcgat ccgccgtcga
    17821 gcatcgcctc gtacacggga ttcttgtgtg ccgcgacatt gaagtcaccc gtgacgatcc
    17881 ggggcagcac gggatccagg ccgcgcagcc gttcggtgat cagggcggcg gaccgctcac
    17941 gcgagtactg attcgcatga tcgagatgag tattgagcgc atagaactcg ccccccgtac
    18001 gcacgtcccg gaatcgcgcc caggtcacca tcctgatgac ggtgtttccc caggtcgtcg
    18061 acccgatcag atacggcgta tcggacagcc agaaatggtc gtactcgacc ggagcgagtc
    18121 gccgcacatc atagaaaacc gtcgcgaact catccttact cccgccgccc cgccccgtcc
    18181 ccacccagtc gtaatgcggc ccgagatcct ccgcgatgtc ccgcacctgc ccgtacagcc
    18241 cctcctgggt cccgagcagc tgcggcgcct cccgacgcag taatgcccgc atcacgggcc
    18301 gccgctcggc ccaggagttc ggcctggtgt ccgaggcgta ccgcaggttg aaggtcatca
    18361 cccgcagccc ccgccggccg tcggcggcgt acgcggtccc ggacccgtac gccgcagcca
    18421 ccgccggccc ggcgatcgcg gcagcagcca ccgcccgtaa tccgaaccgc cgactgaacg
    18481 gcgccctcac cccccggccc tctcgggaac cggaatccaa gaagccaccc aaagaaccgt
    18541 ccgaggaact ggacgatcca ttcgacacgg aaccgagagc actcaccaca actccagtca
    18601 gtcggtcagt cggccagtca gtcgaacccg tcactcatca cgaacaatca ccggaaccac
    18661 cgcagcaccg cagcaccatc aagacagagt ctcgaacatc tcaaacaccg cggtaagccg
    18721 gaagtagcct gcaaacaaac cgacttgaaa ccttccccgg accggaagaa gcgctctccg
    18781 cccgcctcgt ccccttacct accgatcgcc cgccggcccc cgccagtccg catgccggat
    18841 acgggagatc tcccgtacgt caccgaccgt gccccactcg tccttgccca accgcgacaa
    18901 cggcttgagc ttggagatct cggggtgccc gtcgaccagc acatcctgcg acaccaccgc
    18961 atgcaccacg cgcccgaaca cgatggtgga atccccgatc ccgatcgtgg tgtgcacctc
    19021 acactccaac gccacggacg agcccgccac ccgcaacggc ttgacccgca aactcggctc
    19081 ggattcgacc ccggcagcct cgaactcact caccccgtgc gggaagtccg tgcccgtgtc
    19141 attgatctgc tcgaactgcc cctccgacgc gaagttcacc acgaactgtc cggtcgcctc
    19201 gatattgcgc aaagtgtcct tgcgcccgac ggagctgaac tgcacaacgg gcggcgcgac
    19261 gctggcgatg gtgaagaacg aatgcggggc aaggttcgct gaatcactat atgggtcgta
    19321 cgtcgacacc caggcgatcg gacgcggcac caccaccgcg gtcaggagct tgtagaactc
    19381 gttgcgggac atggcagcgg gatcaaagtc aatgcgcatg gtgatcagta tccacacggg
    19441 cggccgcgga tcctacagcg gatccacggc acccccaaac ccctgagtgc gacggaaagt
    19501 gcccggtatc ggagccgacg agcaccagga gcccgacacc gtgacgacag ccgtgaccgt
    19561 ctgggaggac ttcgacgtcc ccgcgcacgc ccgtgggggc caggtcaccc tcaacctcta
    19621 cgaccacctg gccgcctacg cccccaaacg gccaggcgcc tatctccgta tctcctccga
    19681 ccgcttcggc ctcgaagcag gcgtcgaccg ccagctcgaa gacgccgagg actccaggac
    19741 ccgcctgcgc tggggcccgt tcgcgaaggt ctaccgggag aacgacacct cggccttcaa
    19801 aaagcgcaaa gtcatcaagg ccgacggctc catcgactgg atcgtcctgc gccccgagtt
    19861 ccgccagctg ctcgccgacc tcgcccacgg cgtcatcgac ggagtcatct tctacgacct
    19921 cgaccggctc gtccgccagc cccgggacct cgaagacctc atcgacatcg tcgaatacgt
    19981 caaacggccg gtcaccggcg ccaccggcag ccgcatgaac ctcatcaacg acagcgaccg
    20041 tcacatgacc cgcatgatgt gcgtgatggc gctcaagtcc tccgaggaca ccgcccgccg
    20101 cgtcgcccac caacacctct ccgcagccca gaacggactc acccaaggcc gcatcgccta
    20161 cggctgggtc cgcaaaggcg agagcaaggg aaagctggtc cccgatgagg cggacgtcgt
    20221 cgtccggatc ttccagcact tcatgtccgg ggaatcggct acagcatcgc caagaccttc
    20281 aatgccgaag gaatcgagcc gcctgccgcc catacctggt cctcgacgat gatcgccaag
    20341 atgctgcgta atccccgcta tgcgggcatg gtctcctacg ccggcaagca ccgggttcag
    20401 gctgccatgg ccggtgacgg ctggtccatg gtgctcttcg acgacgaggg gcgccccttg
    20461 ctgccggggg gcgagccgcg tgaagccgac gtcgaggggt acccgtggct cagctctccc
    20521 cagctcggca tactggcgac cacgccacct tgtaggagcc agcgtgtcga tgatccacaa
    20581 ccttcgcaaa gcagtccaca tcccgagcac gcgcccgcac ggcgtggatc tcagccatcc
    20641 ggcgcggtcc ccgctgggca actgcgtcgt gaactgcgcg gtctatgtgg acggtgtgcg
    20701 ccaggtcagc cactgcccgg cgcgcaaggc gatcgagcag gtccgcgaga ccggtaacgg
    20761 cttcgtatgg atcggtctgc acgagccagc ggaggaggag ttctccgaga tcggcgaact
    20821 tttcgggctg cacccgctgg ccgtggagga tgccgtcgat gcccaccagc ggccgaagct
    20881 ggagcggtac aacgacacgc tcttcaccgt tctgaagacc gtcacctacg tcgagcacga
    20941 ccggctcacc gcgacgagcg aggtggtgga caccggggaa atcatggtct tcaccggacc
    21001 cgacttcgtc atcacggtcc ggcacggcgg ccacggctcg ctggggccgc tccgcgaaag
    21061 cctcgaatcg acgcccgctc acctggccaa gggcccttcc gccgtcctac acgccgtagc
    21121 cgaccacgtc gtcgatgact acctggcggt catatccgcc gtgcaggacg acatcgacgc
    21181 ggtcgagagc gaggtcttct cggaccaccg gggacgtggc gttgatgccg gccggatcta
    21241 ccagctcaag cgtgagctgc tggagctcaa gcacgccgtg gtaccgctgg accggcccat
    21301 tcagctgctc gccgagcagc ccacacagct ggttgacgcc gacatccgga agtacttccg
    21361 tgacgtcgcc gaccacctgg cccgggtcaa cgagcacgtc accgcctgcg acgagctgct
    21421 caactcgatc cttgaagcca acgtcgccca ggtgtccatg gcccagaacg aggacatgcg
    21481 caagatcagc gcctgggtcg ccatcatcgc cgtccccacc atggtctgcg gcgtgtacgg
    21541 gatgaacttc gagtacatgc ccgagctgcg ctggaccttc ggctatccgc tggtcctcgc
    21601 cggcatggcc accgcctgtt tcctcatgta ccgcgggttc cgccgcaacg gctggctctg
    21661 aggaaccgtt cggccggccg cgcagggacg tcggtggcgc cgccacccgc ctcactgagc
    21721 acaagtgcct ctgtgtcagc ccgagttggc ggtgaggtga ctacgtctgt cctccgcgat
    21781 ccattgcagc acggtggccg ggggcagccc ggagtcctgc gctatggccc gtggcgggac
    21841 acccgcccgt gaggcggcaa gtgcggccct tcgcagggtg gcgaagcggg cggccaggcc
    21901 ggcgcggagt gcgccggcgg aggccgccgt gagagcgggg gcttcctcgg ccaggcagcg
    21961 ggcggcgaac catacggcgc ggcgttctcg cgtcaggtca tggtcgttca tgccactgtc
    22021 tcccgttcgg cttcggcggg cgtcgcgtcc aggtgccagt gcaggtcgcg gatgcccggt
    22081 tccagggaca tccgggcaat gagctg
//
