LOCUS       NZ_CP084681            11212 bp    DNA     linear   CON 30-APR-2024
DEFINITION  Streptomyces inhibens strain NRRL30439 chromosome, complete genome.
ACCESSION   NZ_CP084681
VERSION     NZ_CP084681.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces inhibens
  ORGANISM  Streptomyces inhibens
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9696490)
  AUTHORS   Barry,C.P., Gillane,R., Talbo,G.H., Plan,M., Palfreyman,R.,
            Haber-Stuk,A.K., Power,J., Nielsen,L.K. and Marcellin,E.
  TITLE     Multi-omic characterisation of Streptomyces hygroscopicus NRRL
            30439: detailed assessment of its secondary metabolic potential
  JOURNAL   Mol Omics 18 (3), 226-236 (2022)
   PUBMED   34989730
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9696490)
  AUTHORS   Barry,C.P., Palfreyman,R. and Marcellin,E.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-OCT-2021) EMS, Australian Institute for Bioengineering
            and Nanotechnology, Cnr College Rd & Cooper Rd, Brisbane, Queensland
            4103, Australia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. APRIL-2018
            Assembly Name                     :: AIBN_shyg
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 239.0x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022221585.1-RS_2024_04_30
            Annotation Date                   :: 04/30/2024 04:58:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,775
            CDSs (total)                      :: 8,682
            Genes (coding)                    :: 8,305
            CDSs (with protein)               :: 8,305
            Genes (RNA)                       :: 93
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 377
            CDSs (without protein)            :: 377
            Pseudo Genes (ambiguous residues) :: 0 of 377
            Pseudo Genes (frameshifted)       :: 158 of 377
            Pseudo Genes (incomplete)         :: 310 of 377
            Pseudo Genes (internal stop)      :: 38 of 377
            Pseudo Genes (multiple problems)  :: 116 of 377
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:32:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 126788
            Orig. end                         :: 138000
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP084681.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Australian Institute for
            Bioengineering and Nanotechnology, Building 75,Cnr College Rd &
            Cooper Rd, Brisbane City QLD 4072.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11212
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11212
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11212
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6212](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6212)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(723..738)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 22.29"
                     /tool="antismash"
     misc_feature    complement(859..873)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.96"
                     /tool="antismash"
     gene            867..1061
                     /locus_tag="KI385_RS00615"
                     /old_locus_tag="KI385_00615"
     CDS             867..1061
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KI385_RS00615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KI385_00615"
                     /product="hypothetical protein"
                     /protein_id="WP_238570280.1"
                     /transl_table=11
                     /translation="MRRPAIAIAVRGLVMPASRAVYYDDLGAAFGLTMEVTGPDTGPPA
                     LTDPAQRQPAPHTRHRPGK"
     gene            complement(1077..2201)
                     /locus_tag="KI385_RS00620"
                     /old_locus_tag="KI385_00620"
     CDS             complement(1077..2201)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016575754.1"
                     /locus_tag="KI385_RS00620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_00620"
                     /product="NADH:flavin oxidoreductase"
                     /protein_id="WP_238570281.1"
                     /transl_table=11
                     /translation="MTPTASTDRAAQILSRPVSLNGLTVANRITMAPMTRQFSPGGIPG
                     DDVASYYARRAAAGVGLIVTEGTYVGHESAGDRDQVPRFHGEEQLAGWAEVAEAVHAVG
                     GAIVPQLWHVGMVRSAGWPPFPGAPALGPSGIGVDGTEGAGNAMTQQDLDDVIAAFAAA
                     AAAAERIGFDGVELHGAHGYLVDQFLWSTTNRRTDAYGGDLVARTKFATEVVAAVRAAV
                     SPSFPVIFRYSQWKMAAYNARLAGTPEELEAILTPLAEAGVDAFHASTRRNWLPAFDGS
                     DLNLAGWTKKLTGKPVITVGSVGLDGEFLRSFQGEGSQIKDIDDLLDRLEREEFDLVAV
                     GRALLQDPEWAAKVLGGRFGELAAYDPAALRTLS"
     gene            complement(2455..3345)
                     /locus_tag="KI385_RS00625"
                     /old_locus_tag="KI385_00625"
     CDS             complement(2455..3345)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF017532.4"
                     /locus_tag="KI385_RS00625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_00625"
                     /product="phytanoyl-CoA dioxygenase family protein"
                     /protein_id="WP_238570282.1"
                     /sec_met_domain="PhyH (E-value: 1.4e-07, bitscore: 30.9,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALAPLHESLLGELHLRQVLEGRLVVVRGALDQLTGRDTVRRAAL
                     ASVTSAVSPQAADRLAEQGLEHLHRVAGAEQIRAVRDELDRRLRPTAQRLLLRFAQALP
                     PQGRRLYVSDHLGVRIMPPQAAVRGREEELSNFTGFLLPSQAHTDSWFNTAVNSVNLWM
                     ALSRVRRDNGLTLWPQAYRRPLRHEGVRLLPDQPIGDPVEVELEPGDLLLFAGDHLHAT
                     HPNTGPQTRWVVTKRLCWGPPRYHPRATGWVPYRDPRLLDTPLHALAPLRSALTLGRLR
                     QLARDTDRLLTRLRH"
     misc_feature    complement(2476..2478)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(3355..4203)
                     /locus_tag="KI385_RS00630"
                     /old_locus_tag="KI385_00630"
     CDS             complement(3355..4203)
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019846.4"
                     /locus_tag="KI385_RS00630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_00630"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_238570283.1"
                     /transl_table=11
                     /translation="MTAPSRPSGLRDPQTYLRNNREMWRQWTPLKAASAQYDLAGFRAG
                     GCRMRALECAEVGEVRGRSLLHLQCHVGLDTLSWARLGARVTGVDFCAEGVATARSLAA
                     DVAPSAVFVEADVLDLPSHLDGVFDIVYTSHGVLGWLPDLRRWAEVVAHFTAPGGFLYV
                     FESHPAAWMLDNKVEHPELKLRYSYFGEPEPLAFEYRSPIAVPDAELPGVEYAWGHSLG
                     DVVSALAAAGLRVEFLHEWPFVAWRMLPFMPQDQDGWWRLPDGLPPLPLSFSLRATKPS
                     T"
     gene            complement(4200..4943)
                     /locus_tag="KI385_RS00635"
                     /old_locus_tag="KI385_00635"
     CDS             complement(4200..4943)
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019846.4"
                     /locus_tag="KI385_RS00635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_00635"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_238570284.1"
                     /transl_table=11
                     /translation="MTTVPRYATDFADRYDDWFTPPAASTRATVDLLAQLARSAPPGPL
                     LELGIGTGRVALPLAERGHQVHGIDAAKTMVDQLRAKPGGEQLTISIGDFAEVDHDGEF
                     AMVYVANGSFFELASQQDQLRCFARVARRLLPGGLFVLDAHLPEALAANTGAGAQPVES
                     ANGDPVLRTRRLHPASQRYISDYLVLDEGMFRHVRVAFRYAAPGELDLMAAAAGLRLRE
                     RFGDWSGGAFNDSSSGHISVYELPA"
     gene            complement(5001..6212)
                     /locus_tag="KI385_RS00640"
                     /old_locus_tag="KI385_00640"
     CDS             complement(5001..6212)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF014661.4"
                     /locus_tag="KI385_RS00640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_00640"
                     /product="YcaO-like family protein"
                     /protein_id="WP_238570285.1"
                     /sec_met_domain="YcaO (E-value: 2.4e-24, bitscore: 85.6,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPSAARAVPTTWHPQVFEPFPGESRLLFGRVAARSPQFDATASA
                     GGQRVLIGSAAGTEAAEVAVRARGELLERLGNVLAGRAAEASAALVATYAALRRRRAPA
                     LDPAPWSGPEGRTACQLWVTGRSLLSGTEILVPAALAFLQHRPPAGCTAPVRVGSTGLA
                     AHPDRSTAVEHAAWEILERDLLRRSWQAPAEHPPAAAGVRGEVPLPLGRVCERLGLLAT
                     ALTLPAPGACVVAVCLHAPDGREQTFGARCGPATDRADLLARAVYEALMVRWSMSTPAA
                     HRAYQRLALTGAPASAVEHALWTYHGGQDALARWLQHDVPAPEAPGVEDPMASVDPMAS
                     VDPVAAVDPVRLLAEHTADDVLALDTAPAELREQHVAVVRLLSPGARPLPSVATPGTPP
                     HPFG"
     gene            complement(6236..7126)
                     /locus_tag="KI385_RS00645"
                     /old_locus_tag="KI385_00645"
     CDS             complement(6236..7126)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04267.2"
                     /locus_tag="KI385_RS00645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_00645"
                     /product="HEXXH motif-containing putative peptide
                     modification protein"
                     /protein_id="WP_238570286.1"
                     /transl_table=11
                     /translation="MLRVAPDALEATRDEEAVRRVAQGVLAAAGVRTAAAAGPVIVAAA
                     FAVQAGLRVEMTESQNTATREPLEPVGPAPYLARSVARALATRPDGAEATGGSQLTGWQ
                     RADHAILDRCRAALAAAWPEMLAELRVCVAQVALLEGRAIDGFTDFATHGALYINRARL
                     GASPLGLPGPVRFAEALVHEGTHTRCNAAQLSNPFLTPAAGGADLVRTPLRSDPRPLAG
                     LFQQAVVLVRCTALYRRLLNTESTATAALTARHDRLSDGARQAIGTLRQHSATLTEHGL
                     AVLGECDALLRPTAV"
     gene            7738..8880
                     /locus_tag="KI385_RS00650"
                     /old_locus_tag="KI385_00650"
     CDS             7738..8880
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012744.4"
                     /locus_tag="KI385_RS00650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_00650"
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_238570287.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 2.4e-18,
                     bitscore: 65.3, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIAYLHSGSIPSVYANGVHVMRMCDALTDAGHEVVLHALAGTAP
                     ADDIHAYYGTRNRFEVRTLAHPAVPGLGRWIRVWRVRAELRRRGVPDLLYGRDPYTLLA
                     CSDLAPVAYETHLLWPRWGVRAVERLLLRRRNLRRVVFVSQALADDYRAAFPELTALRH
                     ADLVTAHDCADPVPADGPVAPLPGREGALRIGYIGHLYPGRGTDVILELAEHLPDADFH
                     LVGGTATDRAHWQGRCRQPNVYFHGHHPPAELAPFYRAFDIVLAPYQRRAYCVGGVGEI
                     SRWVSPMKLFEYMSYGKAVIASDLPVLREVLADGVNCLLCPPDSVADWAKAVKRLAEDT
                     SLREALGAEARRQLTERYTWRARADRILPAVQAAAGPGSR"
     misc_feature    complement(7778..7793)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.03"
                     /tool="antismash"
     gene            8880..9824
                     /locus_tag="KI385_RS00655"
                     /old_locus_tag="KI385_00655"
     CDS             8880..9824
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: TD (4-204). E-value: 1.1e-09. Score:
                     29.9. Matches aSDomain: nrpspksdomains_KI385_RS00655_TD.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF027681.4"
                     /locus_tag="KI385_RS00655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_00655"
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /protein_id="WP_238570288.1"
                     /transl_table=11
                     /translation="MRAVVTGAAGFIGSHLCAHLLGAGDTVVGLDALTDYYDPALKSRN
                     LSELVPHPAFIWHRADLLEADLGPLLDGAEVIYHLAGQPGVRPSWGPEFTRYADRNLLA
                     TQALVEAARHLRLRKFVYASSSSVYGNAPTFLTPETVCPRPVSPYGVTKLAAEHVCELY
                     RISYGLPSVSLRLFTVYGPRQRPDMAFARLIDAALTGEPFPLYGDGEQTRDFTYVRDVV
                     TAMRAAACAGFTGVANLGGGCPVSMKQAVATVEQLVGPVTLEPRPGGPGEARHTGADIT
                     LAAREFGYRPRTDLYDGLAAMVRHTTAWRCLDG"
     CDS_motif       8889..8951
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_KI385_RS00655_0001"
                     /evalue="4.30E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="KI385_RS00655"
                     /protein_end="24"
                     /protein_start="3"
                     /score="9.8"
                     /tool="antismash"
                     /translation="VVTGAAGFIGSHLCAHLLGAG"
     aSDomain        8892..9491
                     /aSDomain="TD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KI385_RS00655_TD.1"
                     /evalue="1.10E-09"
                     /label="KI385_RS00655_TD.1"
                     /locus_tag="KI385_RS00655"
                     /protein_end="204"
                     /protein_start="4"
                     /score="29.9"
                     /tool="antismash"
                     /translation="VTGAAGFIGSHLCAHLLGAGDTVVGLDALTDYYDPALKSRNLSEL
                     VPHPAFIWHRADLLEADLGPLLDGAEVIYHLAGQPGVRPSWGPEFTRYADRNLLATQAL
                     VEAARHLRLRKFVYASSSSVYGNAPTFLTPETVCPRPVSPYGVTKLAAEHVCELYRISY
                     GLPSVSLRLFTVYGPRQRPDMAFARLIDAALTGEPFP"
     gene            9817..10392
                     /locus_tag="KI385_RS00660"
                     /old_locus_tag="KI385_00660"
     CDS             9817..10392
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (extras)
                     Sulfotransfer_4: Sulfotransferase domain"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF036807.4"
                     /locus_tag="KI385_RS00660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KI385_00660"
                     /product="sulfotransferase family protein"
                     /protein_id="WP_238570289.1"
                     /transl_table=11
                     /translation="MADGRPLRPKVFGLGLSRTGTRSLTTALHTLGFDVAHYPCDPGTY
                     QALVDGTARFPLLAERDGITDITVAPYYEELDLAWPGAKFILTVREERSWLRSCAYHWE
                     RPIASKADPDSLYVQLQRFLRAAVYGCHEFDAARFARVHRRHVEQVRRYFDGREGDLLI
                     LDIVGGQGYERLAPFLGVPIPDEPFPRF"
     gene            complement(10639..10920)
                     /locus_tag="KI385_RS00665"
                     /old_locus_tag="KI385_00665"
     CDS             complement(10639..10920)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KI385_RS00665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KI385_00665"
                     /product="hypothetical protein"
                     /protein_id="WP_238570290.1"
                     /transl_table=11
                     /translation="MLMVTWNRSRNRGSYVIRTTRLTVLGQPVELGEEPAAVEQSVEGS
                     LVLDAALVQDDDAVGDAVLVRLWVTKSAMQPVASVLKRPQLTVPPVGR"
ORIGIN
        1 atcatcaccc ccgccgtgcg ggcactgcgc cgacgccacc cggatgccga cgtccacacc
       61 ctgcacctgt cgtggaacga accccgcgac gccctgctgg accaccgggc ggacgtggtg
      121 gtggcccggc tgccgttcac gaccgaccag ctgcgcgtga ccgtcctgta cgacgagccg
      181 cggctgctgc tggtgcccgt cgaccaccgc ctggtcggca aggagtccgt caccctcgac
      241 gacatcgccg acgaacccac cccccgcctg cgcgacaccg catggaacac ctactggcgc
      301 atcgaccccc ggcccgacgg acgccgcgca cccgacgggc ccctggcaca gacgatggag
      361 gacaaactcg aattcgtcgc cgccggggac gccgtcgccg tcgtaccagc cggggccgtg
      421 gccacccaca gccgccccga cctgacgacg atccctctgg aaggagtcga ccccgggcac
      481 gtcgtgctcg ccacccgcgc cgatgaccac agccgcctgg tcaccgcctt ccgcaccgcc
      541 gcccaagccc acctcaccgg tcccacccag ccctgaccag ccccaagggc agccggcttg
      601 ccgaggcttc cgcctcgggc agtgaccgat gcaggttgct cgtcaacaac tgccgaagca
      661 gctaactgcg gcgacggtga acctggtcgt ggctctggct acgactcgca ccagcggacc
      721 agcggaccag cgggtcaacg gatcagccgc agtctgcctc cagaggtcag ggccgagtcg
      781 tggtgtgtca ggcctgactc cgggccagtt cccgctcgtg ttgcggcgcg tggtcgtggc
      841 ggggtagcag gagcggggtt gtcaggatga ggagaccggc catcgcgatt gcggtgcggg
      901 ggctggtgat gccggccagc agggccgtct actacgacga cctcggcgcc gcgttcgggc
      961 tcaccatgga ggtgaccggc cccgacaccg gtccacccgc actcactgat ccggcgcagc
     1021 gacaacccgc accccacacg cgccaccgcc cgggaaagta aggctccccc acccggtcag
     1081 ctgagcgtcc gcagcgccgc cggatcgtac gccgccagct ccccgaaccg ccctcccagc
     1141 acctttgccg cccactccgg atcctggagc agcgcacggc ccacggctac caggtcgaac
     1201 tcctcgcgtt ccaggcggtc aagaaggtcg tcgatgtcct tgatctggga accctcgccc
     1261 tggaagctgc ggaggaattc gccgtccagg ccgaccgagc cgacagtgat gaccggcttg
     1321 ccggtcagct tcttcgtcca gccggcgagg ttgaggtcgg agccgtcgaa cgcggggagc
     1381 cagttgcggc gcgtcgaggc gtggaaggcg tccacccccg cctcggccag cggggtcagg
     1441 atggcctcca gttcctccgg agtccccgcg agcctcgcgt tatacgccgc catcttccac
     1501 tgcgagtagc ggaagatcac cgggaatgac ggcgagaccg ccgcgcgcac cgcggccacg
     1561 acctccgtcg cgaacttcgt acgggccacc aggtcaccgc cgtacgcgtc cgtacgccgg
     1621 ttggtcgtcg accacaggaa ctggtcgacg aggtagccgt gggcaccgtg cagctcgacc
     1681 ccgtcgaagc cgatgcgctc cgccgcggcc gcggccgcgg cgaacgccgc tatcacgtcg
     1741 tcgaggtcct gctgcgtcat cgcgttgccg gcgccctcgg tgccgtcgac gccgatgccg
     1801 gacgggccga gcgccggggc gcccgggaac gggggccagc cggcgctgcg gaccatgccg
     1861 acgtgccaca gctgcggcac gatcgccccg cccaccgcgt gcacggcctc ggcgacctcc
     1921 gcccagcccg ccagttgctc ctcgccgtgg aagcgcggaa cctggtcacg gtccccggcc
     1981 gactcatgac ccacgtaggt gccttcggtg acgatcaggc cgacgcccgc ggcggctcgg
     2041 cgcgcgtaat acgacgccac gtcgtcgccc gggatcccgc ccggggagaa ctgccgggtc
     2101 ataggtgcca tcgtgatccg gttcgcaacg gtcaggccgt tcagcgagac cggtcgggac
     2161 aggatctgag ctgcacggtc ggtggatgcc gtgggggtca cttgggggct cctcgcggaa
     2221 acagttggcc agggcaggcg tgtgtgtgcc gtagtgatca actggcccac gcgccaagcc
     2281 actccgccac cccaccgtga tcccgaatac gcccgagggc ggcatccctg gggcgtgccg
     2341 cacggcgagg cgaacgcgct tgccgttgct gcctgcttat gtcgagcgtc gaaggcttcg
     2401 gtcgggcggt ggaagacggg cagcagaccg gggccacagc tgcgccgggg caggtcagtg
     2461 gcgcagcctc gtgagtaacc ggtctgtgtc gcgggcgagt tgacgaaggc ggccgagggt
     2521 gagggctgat cgcagggggg ccagggcgtg caggggggtg tcgagcaggc gggggtcgcg
     2581 gtaggggacc cagccggtgg cgcgcgggtg gtagcgcggc gggccccagc agagccgttt
     2641 ggtgaccacc cagcgggtct gcgggccggt gttcgggtgg gtggcgtgga ggtggtcgcc
     2701 ggcgaagagc agcaggtcgc ccggttccag ttcgacctcc accgggtcgc cgatcggctg
     2761 gtcgggcagc agtcgcaccc cctcgtgccg cagtgggcgc cggtaggcct gcggccagag
     2821 ggtcaggccg ttgtcgcgac gtacgcggct gagggccatc cagaggttga ccgagttgac
     2881 ggccgtgttg aaccaggagt ccgtgtgcgc ctggctcggg agcaggaagc ccgtgaagtt
     2941 gctcagttcc tcctcccggc cacggacggc ggcctgcggc ggcatgatcc gcacgcccag
     3001 gtggtcgctc acatacagcc ggcgcccctg cggcggcagc gcttgggcga agcggagcag
     3061 cagccgctgg gcggtcgggc gcaggcggcg gtccagctcg tcgcggaccg cccggatctg
     3121 ttcggcgccg gcgacgcggt gcaggtgttc caggccctgc tccgccagcc ggtcggccgc
     3181 ctgtggtgag acggccgacg tgacggacgc gagcgccgcg cggcggaccg tatcgcggcc
     3241 tgtgagctgg tccaacgcgc cgcggaccac gaccagtcgg ccctccagca cctggcgcag
     3301 gtgcagctcg ccgaggagtg actcgtgcag gggcgccagt gccacgttcc ctcctcaggt
     3361 ggacggcttg gtcgcgcgca gtgagaagga cagtggcagg ggcggcaggc cgtccggcag
     3421 ccgccaccag ccgtcctggt cctggggcat gaacggcagc atccgccagg ccacgaacgg
     3481 ccactcgtgc aggaactcga cccgcagccc ggcagccgcg agggcgctca cgacatcgcc
     3541 gagagagtgt ccccaggcgt actccacgcc gggcagctcc gcgtcgggca ccgcgatcgg
     3601 gctgcggtac tcgaaagcca gcggctcggg ctcgccgaag taggagtacc gcagtttcag
     3661 ttcggggtgc tcgaccttgt tgtcgagcat ccaggccgcc gggtgcgact cgaagacgta
     3721 gaggaagccg ccgggcgcgg tgaagtgcgc gacgacctcc gcccagcggc gcaggtccgg
     3781 cagccagccg agcactccgt gcgaggtgta gacgatgtcg aagacgccgt cgagatggga
     3841 cgggaggtcg agcacgtccg cctccacgaa gacggccgaa ggggcgacgt ccgcggccag
     3901 ggagcgggcg gtggccacgc cctcggcgca gaagtccaca ccggtcaccc gcgcgcccag
     3961 tcgcgcccag gagagcgtgt ccagcccgac gtgacactgc aggtggagca gtgagcggcc
     4021 gcgcacctcg ccgacctcgg cacactccag cgcccgcatc cggcagccgc cggcccggaa
     4081 cccggccagg tcgtactggg cggaggcggc cttcagcggc gtccactgcc gccacatctc
     4141 gcgattgttc ctcagatacg tctgcgggtc gcgcagcccg ctcggcctgc tcggcgccgt
     4201 catgccggca gctcgtagac gctgatgtgc ccgctgctgc tgtcgttgaa ggcaccgccg
     4261 gaccagtcgc cgaaccgctc acgcaaccgc agaccggcgg ccgccgccat caggtcgagc
     4321 tcgcccgggg cggcgtaacg gaaggccacc cgtacgtgcc ggaacatgcc ctcgtcgagc
     4381 accaggtagt cggagatgta gcgctgggag gcggggtgga gccggcgggt gcgcaacacc
     4441 gggtcgccgt tcgcgctctc cacgggctga gcgcccgcgc cggtgttggc cgccagtgcc
     4501 tcgggcaggt gggcgtccag gacgaacagc ccgccgggca gcaggcgtcg cgccacccgc
     4561 gcgaagcagc gcagctggtc ctgctgggag gcaagttcga agaaggagcc attggcgaca
     4621 tagaccatgg cgaactcgcc gtcgtggtcc acttcggcga agtcaccgat gctgatggtg
     4681 agttgttcgc cgccgggctt ggcccggagt tggtcgacca tggtcttcgc ggcgtcgatg
     4741 ccatggacct ggtgcccgcg ctcggccagc ggcagggcca cccggcccgt accgatcccg
     4801 agttcgagca acgggcccgg cggcgcgctg cgggccagct gcgccagcag gtccacggtg
     4861 gctcgggtgc tggcggcggg cggggtgaac cagtcgtcgt agcggtcggc gaagtcggtg
     4921 gcgtagcggg ggaccgtcgt catcgtgctc cttgggaagg tcagccggag aggtcaaccg
     4981 gaagggatca gccgaagggg tcagccgaag gggtgcggcg gggtgccggg ggtggccacg
     5041 gagggcagcg ggcgggcgcc tggagagagc aggcggacga ccgccacgtg ctgctcgcgg
     5101 agctcggcgg gggccgtgtc gagggcgagg acgtcgtctg cggtgtgctc ggcgagcaga
     5161 cgcaccggat ccacggccgc cacggggtcc acggaggcca tggggtccac ggaggccatg
     5221 gggtcctcca cgcccggcgc ctctggagcg ggtacgtcgt gctgcagcca gcgcgccaag
     5281 gcgtcctgac ccccgtggta cgtccacagc gcgtgctcga cggcggaggc cggcgcgccc
     5341 gtcaacgcca gccgctgata ggcgcggtgg gccgccgggg tgctcatgct ccagcgcacc
     5401 atcagtgcct cgtacacggc ccgggcgagg agatcggcac ggtcggtcgc cgggccgcag
     5461 cgggcgccga aggtctgctc gcggccgtcc ggggcgtgca ggcagacggc gacgacgcag
     5521 gcacccggcg cgggcagagt cagcgcggtg gcgagcaggc cgaggcgctc gcacacgcgg
     5581 cccagcggca gggggacttc gccgcgcact ccggcggcgg cgggcggatg ctcggcgggg
     5641 gcctgccagc tgcggcgcag caggtcacgt tccaggatct cccaggccgc gtgctcgacg
     5701 gccgtggacc ggtccgggtg ggccgccagg cctgtggagc cgacgcgtac cggagcggtg
     5761 cagccggcgg gcgggcggtg ctggaggaaa gccagtgcag ccgggaccag gatctccgtg
     5821 ccggagagca aggaccgccc ggtgacccag agttggcatg ccgtgcggcc ctcgggcccc
     5881 gaccagggcg ccggatccag cgcgggcgcc cgtctgcgcc gtagtgcggc gtacgtggcg
     5941 acgagtgccg ccgatgcctc cgccgcacgg ccggccagca cattgcccag ccgctccagc
     6001 aactcacccc tggcccgcac cgccacctcg gcagcctcgg tgcccgccgc gctgccgatc
     6061 agcacccgct gcccgccggc gctcgcggtg gcgtcgaact gcgggctacg ggcggcgacc
     6121 cggccgaaca gcaaccggga ctcgccgggg aacggttcga agacctgggg atgccaggtg
     6181 gtcggaacgg cgcgggcagc agagggcggc acagacgggc tcccgggggt ggtggtcaga
     6241 cggcggtcgg gcgcaggagt gcgtcgcact cccccaggac ggcgagtccg tgctcggtga
     6301 gcgtggccga gtgctgccgc agtgtgccga ttgcctgtcg ggcaccgtcc gacaagcggt
     6361 catggcgtgc cgtcagagcg gcggtggcgg tgctctccgt gttcagcagg cgtcggtaca
     6421 gcgccgtaca gcggaccagc acaaccgcct gctggaagag ccccgcgagg gggcgcggat
     6481 cggaccgcag cggggttcgg acgagatcgg caccgccggc cgcgggggtg aggaacgggt
     6541 tgctcaactg ggcggcgttg cagcgggtat gggtgccctc gtggaccagc gcctcggcga
     6601 accggaccgg gccgggcagg ccgagggggc tcgcacccag tcgggcgcgg ttgatgtaga
     6661 gggcgccgtg ggtggcgaag tcggtgaagc cgtcgatcgc ccggccctcc aacagagcca
     6721 cctgcgccac acaaacacgc agttcagcaa gcatctccgg ccaggcagca gcaagcgcgg
     6781 cacggcaacg gtccaatatg gcatggtcgg cacgctgcca gccggtcagc tgcgacccgc
     6841 ccgtggcttc ggcgccgtcg ggccgcgtgg ccagggcacg tgccaccgac cgagccagat
     6901 agggcgcggg tccgacgggc tccagcggct cacgcgtggc ggtgttctgg ctctccgtca
     6961 tctccactcg aagcccggcc tggacggcga aggcggcggc cacgatcaca ggacccgccg
     7021 ctgcggcggt ccggaccccg gctgccgcca acacaccctg cgccacccgc cgtacggcct
     7081 cttcgtcacg ggtggcctca agcgcatcgg gtgctacccg cagcaccggt tcacctccac
     7141 cgagttcaca ctccacctct gggatcggga cctctgagga tcggaccttc gatcggacca
     7201 tcgaggaccg gacctctggc tcgggaacga gcgcggcggg tagccggcgg ccgacctgga
     7261 tcagtcctgg tccggaaagt cgaccatgag tgcgtagtcg gggagctcct cggtgacctg
     7321 ctcgatgtcc tcgtgctcca tgtcagtcct tccgtctctg gtcgcgcacc tcaacgagcg
     7381 tcaactgacg cccaggccga acgtacggtg gccccgatcg gcaggccata cgtgcgtcga
     7441 gctgtcgtac ggaaaccgga cgccggcggt ctcccgtgcg ccggaagccc tggagcgggc
     7501 cacaggacag gcgcaccgtc ggccggttcg ccgctgggtg ggagacgccc gggccgggcg
     7561 ggagtggtgg gacaccagtg actcctggat ctggctgata tcggcaccgg gccgagcggc
     7621 catgcgccgt tgtgcgcccc gacgtgccac cggccgctcg ggaggccctg ttgtggtcga
     7681 agggggtgct gggaagcatg ggcgcccgtc accacgacgc ccggaggtcc atcagccatg
     7741 cggatcgcct atctgcacag cggcagcatc ccctccgtct acgccaacgg cgtgcacgtc
     7801 atgcggatgt gcgacgcgct caccgacgcg ggccacgagg tcgtgctcca cgccctggcc
     7861 ggtaccgccc ccgccgacga catccacgcc tattacggca cccgcaatcg cttcgaggtg
     7921 cgcaccctgg cgcacccggc ggtgccgggg ctgggcaggt ggatccgggt atggcgggtc
     7981 cgggccgagc tccgccgccg tggtgtgccc gatctgctgt acggacggga cccgtatacg
     8041 ctgctcgcct gctcggatct ggccccggtg gcgtacgaga cacacctgct gtggcccagg
     8101 tggggcgtgc gggcggtgga acggttgctg ctgcgcagac ggaacctgcg ccgggtggtg
     8161 ttcgtgtccc aggcgctcgc cgacgactac cgcgcggcct tcccggagct caccgctctc
     8221 cggcacgccg acctggtcac cgcccacgac tgcgccgatc cggtgccggc cgacggcccg
     8281 gtggccccct tgcccggccg ggagggggcc ttgcggatcg gctacatcgg gcacctctac
     8341 cccggccggg gcactgacgt catcctggag ctcgccgagc acctacccga cgccgatttc
     8401 catctggtcg gcggcaccgc gacggaccgc gcacactggc agggccgctg ccggcagccc
     8461 aacgtgtact tccacggcca tcaccctcct gccgaactcg ccccctttta ccgggcgttc
     8521 gacatcgtcc tggcgccgta ccagcggcgg gcgtactgcg tcggaggcgt cggcgagatc
     8581 agccgctggg tgtcaccgat gaagctgttc gagtacatgt cgtacggcaa ggccgtcatc
     8641 gcctcggacc tgcccgtgct gcgggaggtg ctggccgacg gggtcaactg cctgctctgc
     8701 ccgcccgact ccgttgcgga ctgggcgaag gcggtcaaac ggctggccga agacacgtcc
     8761 ctgcgtgagg ccctgggcgc cgaggcccgg cggcagctga ccgagcggta cacctggcgg
     8821 gctcgcgcgg accggatact gcccgctgtc caggcagccg ccgggccggg gagccgctga
     8881 tgcgggcggt ggtgaccggc gcggccgggt tcatcggctc ccatctgtgc gcgcacctgc
     8941 tgggcgccgg agacaccgtc gtcggcctcg acgcactcac cgactactac gacccggccc
     9001 tcaaatcgcg caacctgagc gagctggtgc cccacccggc cttcatctgg caccgggccg
     9061 atctgctgga ggccgacctc ggccccctcc tcgacggggc ggaggtcatc taccacctgg
     9121 ccggccagcc aggcgtccgc ccgtcctggg gaccggagtt cacccgctac gccgaccgca
     9181 acctgctcgc cacccaggct ctggtcgagg ccgcccggca cctccggctg cgcaaattcg
     9241 tctacgcctc cagttcctcg gtgtacggca acgcgccgac cttcctcacc cccgagacgg
     9301 tctgcccccg gcccgtctcg ccgtacgggg tcaccaagct ggcggccgag cacgtatgcg
     9361 agctgtaccg catctcctac ggactgccca gcgtctcgct gcggctgttc acggtctacg
     9421 gcccccggca gcgccccgac atggccttcg cccgcctgat cgatgccgcg ctgaccggcg
     9481 agccgttccc gctgtacggc gacggcgagc agacccgcga cttcacctat gtgcgggacg
     9541 tggtcaccgc catgcgcgcc gcggcctgtg ccggcttcac cggcgtggcc aacctcggcg
     9601 gcggctgccc ggtctcgatg aagcaggcgg tcgcgacggt cgagcagctg gtcgggccgg
     9661 tcaccctcga accacggccg ggcggtcccg gcgaggcgcg gcacaccggg gccgacatca
     9721 cgctggccgc ccgcgagttc ggctatcgtc cacggacgga cctgtacgac gggctggccg
     9781 cgatggtccg gcacacgacg gcctggaggt gcctggatgg ctgacggccg gcccctccgg
     9841 ccgaaggtct tcggcctggg gctgtcccgc accggtaccc gctccctcac caccgccctg
     9901 cacaccctgg gcttcgacgt cgcgcactac ccgtgcgatc cgggtaccta ccaggccctg
     9961 gtggacggca cggcgcgctt cccgctgctt gcggagcgcg acgggatcac cgacatcacc
    10021 gtcgcgccct actacgagga gctcgatctc gcctggcccg gcgccaagtt catcctgacg
    10081 gtccgtgagg agcggagctg gctgcgctcc tgcgcgtacc actgggaacg ccctatcgcg
    10141 agcaaggccg acccggactc gctctacgtt cagctccagc gcttcctgcg ggccgccgtc
    10201 tacgggtgcc acgagttcga cgccgctcgt ttcgcccggg tccaccgccg gcacgtcgag
    10261 caggtgcggc gctacttcga cggccgggag ggcgacttgc tgatcctcga catcgtcggc
    10321 ggccaggggt acgagcgtct tgcccccttc ctcggcgtgc cgatccccga cgagccgttc
    10381 ccccgttttt gatctgccaa gtccaggtcc atcgcccgtg ggtattcctt cacccagggg
    10441 cctgccgggc accggtgcgg ccggccgccg gcatgtatcg caggccccgt tcctgcgcca
    10501 gtgtgcttcc gtcacctggg cgccccgccg gaccggcacg ccgtggacca ggtcagcctc
    10561 accctgcgca gcggcgaact catcgcactg gtagaacggc tccggcaaga ccaccctcgc
    10621 ccgcctgctc accagcctct atctgcccac cggcggcacg gtcagctggg gccgcttcaa
    10681 gacactcgcc accggctgca tcgcactctt cgtcacccac aatctcacca acaccgcatc
    10741 gccgaccgca tcatcgtcct gaaccagggc cgcatcgagg acgagggaac cttcgacgga
    10801 ctgctccacc gcggcgggct cttcgccgag ctctaccggt tgtcccagca ccgttaggcg
    10861 ggtcgtacgg atcacgtagg acccgcgatt ccgcgagcga ttccaggtga ccatgagcat
    10921 cggatgagca tttccatgtg gtcatgggca ctggtgacgt tcagagtgac gatgaccgcg
    10981 atgtatgccc ccgcgcggaa ttactcgtgc cgcaagggcc cgtaccgctc gacgtccgcg
    11041 tgcggcacag cggggtcggg ccgggcgtcg gcgaagtcgt cggcgttcac gccagccttc
    11101 caccgcgagc ggttggcggc ggttcccacg gcgacggcgt tcgcggcgac gatcgcggtg
    11161 atggccagcc acgacgccag gtcgaggtgc tggccgagga cgaacaggcc ga
//
