GCF_022070145.1 - 7 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP035253.1 (Streptococcus pneumoniae)

Region	Type	From	To
Region 1	RiPP-like	48,018	65,958
Region 2	RiPP-like	118,751	139,319
Region 3	RiPP-like	482,788	496,951
Region 4	terpene-precursor	1,095,747	1,116,622
Region 5	T3PKS	1,545,348	1,586,520
Region 6	lanthipeptide-class-ii	1,876,534	1,899,524
Region 7	RiPP-like	1,923,454	1,933,750

NZ_CP035253.1 - Region 1 - RiPP-like

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Location: 48,018 - 65,958 nt. (total: 17,941 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

EQH27_RS00295: aminotransferase

smcogs: SMCOG1019: aminotransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002577.2	0.56	ribosomal	lactococcin G	Lactococcus lactis
BGC0000624.3	0.55	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0002579.2	0.54	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000617.5	0.50	ribosomal	coagulin	Bacillus coagulans
BGC0000619.3	0.50	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.50	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0001388.3	0.50	ribosomal	gassericin E	Lactobacillus gasseri
BGC0000558.5	0.48	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002005.2	0.46	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0001229.4	0.43	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002577.2	0.56	ribosomal	lactococcin G	Lactococcus lactis
BGC0000624.3	0.55	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0002579.2	0.54	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000617.5	0.50	ribosomal	coagulin	Bacillus coagulans
BGC0000619.3	0.50	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.50	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0001388.3	0.50	ribosomal	gassericin E	Lactobacillus gasseri
BGC0000558.5	0.48	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002005.2	0.46	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0001229.4	0.43	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.31 out of 26.06

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 24.43 out of 24.78

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.31 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.09 out of 26.06

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.93 out of 28.19

Confidence: medium

Additional weak hits (3):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.17 out of 26.85

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.98 out of 29.25

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_CP035253.1 - Region 2 - RiPP-like

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Location: 118,751 - 139,319 nt. (total: 20,569 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

EQH27_RS00635: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Lyases: lyase

EQH27_RS00680: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Ligases: synthase

EQH27_RS00675: argininosuccinate synthase

smcogs: SMCOG1291: argininosuccinate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000558.5	0.48	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000623.3	0.48	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0002579.2	0.47	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0001862.4	0.44	ribosomal	pallidocin	Aeribacillus pallidus
BGC0000504.5	0.44	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000554.4	0.44	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002698.2	0.44	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001229.4	0.43	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0002577.2	0.43	ribosomal	lactococcin G	Lactococcus lactis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000558.5	0.48	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000623.3	0.48	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0002579.2	0.47	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0001862.4	0.44	ribosomal	pallidocin	Aeribacillus pallidus
BGC0000504.5	0.44	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000554.4	0.44	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002698.2	0.44	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001229.4	0.43	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0002577.2	0.43	ribosomal	lactococcin G	Lactococcus lactis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.42 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.93 out of 26.06

Confidence: medium

Additional weak hits (6):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 26.23 out of 31.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 26.88 out of 31.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.57 out of 31.73

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.38 out of 29.25

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.21 out of 39.62

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.79 out of 33.14

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes

NZ_CP035253.1 - Region 3 - RiPP-like

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Location: 482,788 - 496,951 nt. (total: 14,164 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001388.3	0.53	ribosomal	gassericin E	Lactobacillus gasseri
BGC0000619.3	0.52	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.52	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0000624.3	0.51	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0000617.5	0.50	ribosomal	coagulin	Bacillus coagulans
BGC0002579.2	0.50	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0002577.2	0.48	ribosomal	lactococcin G	Lactococcus lactis
BGC0001229.4	0.43	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001862.4	0.41	ribosomal	pallidocin	Aeribacillus pallidus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001388.3	0.53	ribosomal	gassericin E	Lactobacillus gasseri
BGC0000619.3	0.52	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.52	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0000624.3	0.51	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0000617.5	0.50	ribosomal	coagulin	Bacillus coagulans
BGC0002579.2	0.50	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0002577.2	0.48	ribosomal	lactococcin G	Lactococcus lactis
BGC0001229.4	0.43	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001862.4	0.41	ribosomal	pallidocin	Aeribacillus pallidus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 18.42 out of 19.52

Confidence: strong

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.08 out of 24.78

Confidence: medium

Additional weak hits (4):

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.21 out of 32.93

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.73 out of 36.54

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.05 out of 33.73

Confidence: weak

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.11 out of 20.47

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
LexA variant 2	Repressor of DNA damage response

NZ_CP035253.1 - Region 4 - terpene-precursor

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Location: 1,095,747 - 1,116,622 nt. (total: 20,876 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: back translocase

EQH27_RS05505: GTP-binding protein LepA

smcogs: SMCOG1190: GTP-binding protein LepA

Ligases: synthetase

EQH27_RS05530: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001605.3	0.32	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000648.3	0.31	terpene	carotenoid	Myxococcus xanthus
BGC0001456.3	0.30	terpene	isorenieratene	Streptomyces argillaceus
BGC0001756.3	0.28	terpene	retigeranin, arathanatriene	Arabidopsis thaliana
BGC0001594.3	0.27	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0001595.3	0.26	other (other)	fischerindole	Fischerella sp. SAG 46.79
BGC0000668.5	0.26	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001605.3	0.32	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000648.3	0.31	terpene	carotenoid	Myxococcus xanthus
BGC0001456.3	0.30	terpene	isorenieratene	Streptomyces argillaceus
BGC0001756.3	0.28	terpene	retigeranin, arathanatriene	Arabidopsis thaliana
BGC0001594.3	0.27	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0001595.3	0.26	other (other)	fischerindole	Fischerella sp. SAG 46.79
BGC0000668.5	0.26	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

EQH27_RS05530: PT_FPPS_like

Domain 1 (27 - 272): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.08 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.39 out of 27.78

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.52 out of 23.79

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.20 out of 24.78

Confidence: medium

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
IolR	Regulator of the inositol catabolism
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes

NZ_CP035253.1 - Region 5 - T3PKS

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Location: 1,545,348 - 1,586,520 nt. (total: 41,173 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: reductase

EQH27_RS07815: hydroxymethylglutaryl-CoA reductase

smcogs: SMCOG1187: hydroxymethylglutaryl-CoA reductase

Transferases: formyltransferase methyltransferase

EQH27_RS07860: methionyl-tRNA formyltransferase

smcogs: SMCOG1228: methionyl-tRNA formyltransferase

EQH27_RS07900: methyltransferase

smcogs: SMCOG1248: methyltransferase

Hydrolases: hydrolase

EQH27_RS07910: isochorismatase

smcogs: SMCOG1027: isochorismatase

Ligases: synthase

EQH27_RS07820: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002700.2	0.45	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0000519.4	0.45	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0002111.3	0.42	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0001521.3	0.41	NRPS	auriculamide	Herpetosiphon aurantiacus DSM 785
BGC0000486.4	0.41	ribosomal	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0002561.3	0.40	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000592.5	0.40	ribosomal	microviridin B	Microcystis aeruginosa NIES-298
BGC0000616.4	0.40	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0000205.3	0.40	PKS	bryostatin	Candidatus Endobugula sertula

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002700.2	0.45	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0000519.4	0.45	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0002111.3	0.42	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0001521.3	0.41	NRPS	auriculamide	Herpetosiphon aurantiacus DSM 785
BGC0000486.4	0.41	ribosomal	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0002561.3	0.40	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000592.5	0.40	ribosomal	microviridin B	Microcystis aeruginosa NIES-298
BGC0000616.4	0.40	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0000205.3	0.40	PKS	bryostatin	Candidatus Endobugula sertula

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.14 out of 20.97

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.40 out of 30.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 27.71 out of 27.78

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.12 out of 23.79

Confidence: medium

Additional weak hits (4):

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.25 out of 30.97

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.07 out of 32.93

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.54 out of 32.74

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 21.39 out of 30.12

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
IolR	Regulator of the inositol catabolism
ToxT	Regulator of MSHA biosynthesis

NZ_CP035253.1 - Region 6 - lanthipeptide-class-ii

Download region GenBank file

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Location: 1,876,534 - 1,899,524 nt. (total: 22,991 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: protease

EQH27_RS09765: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase

EQH27_RS09745: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000500.5	0.60	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000504.5	0.51	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001555.4	0.51	ribosomal	colicin V	Escherichia coli chi7122
BGC0000554.4	0.50	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000590.5	0.50	ribosomal	microcin N	Escherichia coli
BGC0002698.2	0.50	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000622.5	0.49	ribosomal	megacin	Bacillus megaterium
BGC0000623.3	0.49	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000502.5	0.49	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0001407.5	0.49	ribosomal	bicereucin	Bacillus cereus SJ1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000500.5	0.60	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000504.5	0.51	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001555.4	0.51	ribosomal	colicin V	Escherichia coli chi7122
BGC0000554.4	0.50	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000590.5	0.50	ribosomal	microcin N	Escherichia coli
BGC0002698.2	0.50	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000622.5	0.49	ribosomal	megacin	Bacillus megaterium
BGC0000623.3	0.49	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000502.5	0.49	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0001407.5	0.49	ribosomal	bicereucin	Bacillus cereus SJ1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for EQH27_RS09745

EQH27_RS09735

Leader:

MTNFNSNEKFCGKSLKSLSADEMSLIYGA

Core:

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

Core with dehydrations:

DhaDGAEPRWDhbPDhbPIILKDhaAAADhaDhaKVCysIDhaAAVDhaGIGGLVDhaYNNDCysLG

antiSMASH-DB 4.0 matches for EQH27_RS09735

100.0%

NC_003028.3and 39 others:

NC_003098.1 Lanthipeptides: SPR_RS08860_lanthipeptideNC_011900.1 Lanthipeptides: SPN23F_RS10045_lanthipeptideNC_012466.1 Lanthipeptides: SPJ_RS09630_lanthipeptideNZ_CFDV01000030.1 Lanthipeptides: AQB43_RS08315_lanthipeptideNZ_CFVJ01000005.1 Lanthipeptides: AP598_RS03270_lanthipeptideNZ_CGGJ01000006.1 Lanthipeptides: AP607_RS03210_lanthipeptideNZ_CHVQ01000007.1 Lanthipeptides: AQF85_RS04280_lanthipeptideNZ_CJZM01000008.1 Lanthipeptides: AEE29_RS04150_lanthipeptideNZ_CLHL01000007.1 Lanthipeptides: AE723_RS05755_lanthipeptideNZ_CMIW01000004.1 Lanthipeptides: AD046_RS04070_lanthipeptideNZ_CP035253.1 Lanthipeptides: EQH27_RS09735_lanthipeptideNZ_CP082820.1 Lanthipeptides: K8B76_RS08860_lanthipeptideNZ_CPRX01000013.1 Lanthipeptides: AEE77_RS05815_lanthipeptideNZ_CPTT01000011.1 Lanthipeptides: AEH42_RS06005_lanthipeptideNZ_CRAW01000006.1 Lanthipeptides: AK725_RS04390_lanthipeptideNZ_CRXO01000010.1 Lanthipeptides: AKU38_RS05255_lanthipeptideNZ_FCRW01000008.1 Lanthipeptides: A1N73_RS07430_lanthipeptideNZ_FDDE01000015.1 Lanthipeptides: A1A23_RS09710_lanthipeptideNZ_FDFR01000008.1 Lanthipeptides: A1O50_RS09315_lanthipeptideNZ_FDGF01000009.1 Lanthipeptides: A0899_RS06590_lanthipeptideNZ_FDQP01000009.1 Lanthipeptides: A1S42_RS08045_lanthipeptideNZ_FECM01000008.1 Lanthipeptides: A1930_RS06470_lanthipeptideNZ_FEEQ01000001.1 Lanthipeptides: A1T31_RS01150_lanthipeptideNZ_FEOS01000003.1 Lanthipeptides: A1178_RS03090_lanthipeptideNZ_FFTU01000009.1 Lanthipeptides: A1K37_RS06340_lanthipeptideNZ_FHRS02000028.1 Lanthipeptides: A1898_RS09825_lanthipeptideNZ_FIXQ01000010.1 Lanthipeptides: AZ721_RS04795_lanthipeptideNZ_FZDX01000018.1 Lanthipeptides: CFW91_RS09485_lanthipeptideNZ_FZEI01000008.1 Lanthipeptides: CFW58_RS06405_lanthipeptideNZ_JACVHZ010000010.1 Lanthipeptides: ICJ99_RS03885_lanthipeptideNZ_JAGFAE010000038.1 Lanthipeptides: J5E60_RS09010_lanthipeptideNZ_LR216014.1 Lanthipeptides: E0F05_RS09380_lanthipeptideNZ_LR216019.1 Lanthipeptides: E0E94_RS09630_lanthipeptideNZ_LR216027.1 Lanthipeptides: E0E81_RS09200_lanthipeptideNZ_LR216049.1 Lanthipeptides: E0E96_RS09535_lanthipeptideNZ_LR216064.1 Lanthipeptides: E0F31_RS09520_lanthipeptideNZ_LR536843.1 Lanthipeptides: E0F34_RS09595_lanthipeptideNZ_NANQ01000003.1 Lanthipeptides: B5K28_RS01930_lanthipeptideNZ_NAOJ01000022.1 Lanthipeptides: B5K31_RS08010_lanthipeptide

Lanthipeptides: SP_RS09790_lanthipeptide

1

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

1

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

97.8%

NZ_CP035244.1and 3 others:

NZ_CPPE01000023.1 Lanthipeptides: AD654_RS06870_lanthipeptideNZ_FHJP02000011.1 Lanthipeptides: A1O79_RS07380_lanthipeptideNZ_LR216016.1 Lanthipeptides: E0F10_RS10155_lanthipeptide

Lanthipeptides: EQH36_RS09100_lanthipeptide

1

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

SDGAEPRWTPTPIILKSAAASSK+CISAAVSGIGGLVSYNNDCLG

1

SDGAEPRWTPTPIILKSAAASSKICISAAVSGIGGLVSYNNDCLG

45

95.6%

NZ_JALDUX010000010.1:

Lanthipeptides: M1F92_RS09530_lanthipeptide

1

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

SDGAEPRWTPTP+ILKSAAASSKVCISA VSGIGGLVSYNNDCLG

1

SDGAEPRWTPTPLILKSAAASSKVCISALVSGIGGLVSYNNDCLG

45

with 20 more sequence matches

Only the first 10 are displayed here.

91.1%

NZ_JAMYJM010000002.1:

Lanthipeptides: NKE69_RS04880_lanthipeptide

1

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

SDGAEPRWTPTP ILKSA ASSKVCISA VSGIGG+VSYNNDCLG

1

SDGAEPRWTPTPFILKSATASSKVCISAVVSGIGGIVSYNNDCLG

45

84.4%

NZ_MRXY01000010.1:

Lanthipeptides: BTU63_RS06300_lanthipeptide

1

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

SDGAEP WTPTP ILKSAA SSKVCISA +SGIGG+ SYNNDCLG

1

SDGAEPLWTPTPTILKSAARSSKVCISAIISGIGGIFSYNNDCLG

45

77.8%

NZ_CMKL01000017.1:

Lanthipeptides: AD734_RS09115_lanthipeptide

1

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGG

35

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGG

1

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGG

35

54.3%

NZ_CP041405.1:

Lanthipeptides: FLT43_RS14400_lanthipeptide

5

EPRWTPT--PIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

EPR TPT P I + SSKVC+S S IGG+ S+NNDCLG

4

EPRATPTIVPAISAAVRTSSKVCLSLVASAIGGIASHNNDCLG

46

54.3%

NZ_LN884299.1:

Lanthipeptides: BN2762_RS08660_lanthipeptide

5

EPRWTPTPI--ILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

+PR TPT + I++S A SSKVCISA S I G+VS N +CLG

4

DPRATPTIVASIIRSVAQSSKVCISAVGSAISGIVSNNKNCLG

46

53.3%

NZ_JACSPZ010000014.1:

Lanthipeptides: H9635_RS18390_lanthipeptide

5

EPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

EP TP IL +A SSK C+ A+S I GLVSYN DCLG

5

EPHTTP---ILSAATKSSKKCL-GAISAISGLVSYNKDCLG

41

51.1%

NZ_LWAG01000079.1:

Lanthipeptides: A4R27_RS25230_lanthipeptide

5

EPRWTPTPIILKSAAASS-KVCISAAVSGIGGLVSYNNDCLG

45

+PRWTP ++AA S K+CISA S IGG+VSYN +C G

4

DPRWTPIASAAINSAARSSKICISAVGSAIGGIVSYNKNCAG

45

48.9%

NZ_CP094446.1:

Lanthipeptides: L3476_RS23825_lanthipeptide

5

EPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

EPR TP I+ + SSK CISA S I G++S+N DCLG

4

EPRGTPATIV-SAVTRSSKPCISAIGSAISGIISHNKDCLG

43

48.9%

NZ_KB976303.1and 1 other:

NZ_KB976303.1 Lanthipeptides: IGY_RS26035_lanthipeptide

Lanthipeptides: IGY_RS26045_lanthipeptide

3

GAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

G + R PT I++ + ASSK C+S VS I GL+SYN DC+G

2

GVDTRTHPTVIVV--SRASSKACMSG-VSAISGLLSYNKDCIG

41

46.7%

NZ_CP026035.1:

Lanthipeptides: C2H96_RS00305_lanthipeptide

4

AEPRWTP-TPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

45

A+PRWTP +L + S+++CIS S I G+VS+N DCLG

3

ADPRWTPAVSAVLSAVGRSTRLCISGIGSAISGIVSHNKDCLG

45

MIBiG 4.0 matches for EQH27_RS09735

8.9%

BGC0000582.4 (ADR72962.1):

Linaridin: cypemycin

11

TPIILKSAAASSKVCI

26

TP + + S +C+

5

TPTVAQFVIQGSTICL

20

EQH27_RS09740

Leader:

MKNDFVIGKSLKELSLEEMQLVYGG

Core:

TDGADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

Core with dehydrations:

DhbDGADPRDhaDhbIICysDhaADhbLDhaFIADhaYLGDhaAQDhbRCysGKDNKKK

antiSMASH-DB 4.0 matches for EQH27_RS09740

100.0%

NC_003028.3and 45 others:

NC_003098.1 Lanthipeptides: SPR_RS08865_lanthipeptideNC_011900.1 Lanthipeptides: SPN23F_RS10050_lanthipeptideNC_012466.1 Lanthipeptides: SPJ_RS09635_lanthipeptideNZ_CFDV01000030.1 Lanthipeptides: AQB43_RS08320_lanthipeptideNZ_CFVJ01000005.1 Lanthipeptides: AP598_RS03265_lanthipeptideNZ_CGGJ01000006.1 Lanthipeptides: AP607_RS03205_lanthipeptideNZ_CHVQ01000007.1 Lanthipeptides: AQF85_RS04285_lanthipeptideNZ_CJZM01000008.1 Lanthipeptides: AEE29_RS04155_lanthipeptideNZ_CLHL01000007.1 Lanthipeptides: AE723_RS05750_lanthipeptideNZ_CMIW01000004.1 Lanthipeptides: AD046_RS04075_lanthipeptideNZ_CMKL01000017.1 Lanthipeptides: AD734_RS09110_lanthipeptideNZ_CP035244.1 Lanthipeptides: EQH36_RS09105_lanthipeptideNZ_CP035253.1 Lanthipeptides: EQH27_RS09740_lanthipeptideNZ_CP082820.1 Lanthipeptides: K8B76_RS08865_lanthipeptideNZ_CPPE01000023.1 Lanthipeptides: AD654_RS06875_lanthipeptideNZ_CPRX01000013.1 Lanthipeptides: AEE77_RS05820_lanthipeptideNZ_CPTT01000011.1 Lanthipeptides: AEH42_RS06000_lanthipeptideNZ_CRAW01000006.1 Lanthipeptides: AK725_RS04395_lanthipeptideNZ_CRXO01000010.1 Lanthipeptides: AKU38_RS05260_lanthipeptideNZ_FCRW01000008.1 Lanthipeptides: A1N73_RS07425_lanthipeptideNZ_FDDE01000015.1 Lanthipeptides: A1A23_RS09705_lanthipeptideNZ_FDFR01000008.1 Lanthipeptides: A1O50_RS09320_lanthipeptideNZ_FDGF01000009.1 Lanthipeptides: A0899_RS06595_lanthipeptideNZ_FDQP01000009.1 Lanthipeptides: A1S42_RS08050_lanthipeptideNZ_FECM01000008.1 Lanthipeptides: A1930_RS06475_lanthipeptideNZ_FEEQ01000001.1 Lanthipeptides: A1T31_RS01145_lanthipeptideNZ_FEOS01000003.1 Lanthipeptides: A1178_RS03085_lanthipeptideNZ_FFTU01000009.1 Lanthipeptides: A1K37_RS06335_lanthipeptideNZ_FHJP02000011.1 Lanthipeptides: A1O79_RS07375_lanthipeptideNZ_FHRS02000028.1 Lanthipeptides: A1898_RS09820_lanthipeptideNZ_FIXQ01000010.1 Lanthipeptides: AZ721_RS04790_lanthipeptideNZ_FZDX01000018.1 Lanthipeptides: CFW91_RS09480_lanthipeptideNZ_FZEI01000008.1 Lanthipeptides: CFW58_RS06410_lanthipeptideNZ_JACVHZ010000010.1 Lanthipeptides: ICJ99_RS03880_lanthipeptideNZ_JAGFAE010000038.1 Lanthipeptides: J5E60_RS09005_lanthipeptideNZ_JALDUX010000010.1 Lanthipeptides: M1F92_RS09535_lanthipeptideNZ_JAMYJM010000002.1 Lanthipeptides: NKE69_RS04885_lanthipeptideNZ_LR216014.1 Lanthipeptides: E0F05_RS09385_lanthipeptideNZ_LR216016.1 Lanthipeptides: E0F10_RS10160_lanthipeptideNZ_LR216019.1 Lanthipeptides: E0E94_RS09635_lanthipeptideNZ_LR216027.1 Lanthipeptides: E0E81_RS09205_lanthipeptideNZ_LR216049.1 Lanthipeptides: E0E96_RS09540_lanthipeptideNZ_LR216064.1 Lanthipeptides: E0F31_RS09525_lanthipeptideNZ_LR536843.1 Lanthipeptides: E0F34_RS09600_lanthipeptideNZ_NANQ01000003.1 Lanthipeptides: B5K28_RS01935_lanthipeptide

Lanthipeptides: SP_RS09795_lanthipeptide

1

TDGADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

37

TDGADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

1

TDGADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

37

97.3%

NZ_MRXY01000010.1:

Lanthipeptides: BTU63_RS06305_lanthipeptide

1

TDGADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

37

TDGADPRS+IICSATLSFIASYLGSAQTRCGKDNKKK

1

TDGADPRSSIICSATLSFIASYLGSAQTRCGKDNKKK

37

97.3%

NZ_NAOJ01000022.1:

Lanthipeptides: B5K31_RS08015_lanthipeptide

1

TDGADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

37

TDGADPRST ICSATLSFIASYLGSAQTRCGKDNKKK

1

TDGADPRSTTICSATLSFIASYLGSAQTRCGKDNKKK

37

with 20 more sequence matches

Only the first 10 are displayed here.

70.3%

NZ_CP026035.1:

Lanthipeptides: C2H96_RS00310_lanthipeptide

4

ADPRSTIICSATLSFIASYLGSAQTRCGKDNKK

36

AD RST ICSA +SFIA+YLGSA T CGKDNKK

5

ADVRSTPICSAGISFIATYLGSAATNCGKDNKK

37

59.5%

NZ_CP094446.1:

Lanthipeptides: L3476_RS23820_lanthipeptide

2

DGADP--RSTIICSATLSFIASYLGSAQTRCGKDNKK

36

DG D RST+IC SFI SYL SA +CGK NKK

1

DGMDVEVRSTLICGVGASFIGSYLASAAFKCGKKNKK

37

56.8%

NZ_FNYB01000021.1:

Lanthipeptides: BMZ34_RS24360_lanthipeptide

3

GADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

37

G DPR+T SF+ASY+ SAQ RCGKDNK K

2

GVDPRTTP-SPLLASFVASYIASAQYRCGKDNKGK

35

56.8%

NZ_JACSNF010000005.1and 1 other:

NZ_LMPR01000013.1 Lanthipeptides: ASF99_RS16385_lanthipeptide

Lanthipeptides: KNQ12_RS14670_lanthipeptide

4

ADPRSTIICSATLSFIASYLGSAQTRCGKDNKK

36

D RS+++CSA LSF+ SYL SA +CGKDNKK

4

VDVRSSLVCSALLSFVGSYLASAGLKCGKDNKK

36

56.8%

NZ_KB976303.1:

Lanthipeptides: IGY_RS26050_lanthipeptide

3

GADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

37

G DPR+T SF+ASY+ SAQ RCGKDNK K

2

GVDPRTTP-SPLLASFVASYIASAQFRCGKDNKGK

35

55.3%

NZ_LWAG01000079.1:

Lanthipeptides: A4R27_RS25235_lanthipeptide

4

ADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

37

A+ RST+IC A +S I SYL SA +CGKDNK K

5

AEARSTLICGAGISLIGSYLASAAFKCGKDNKGK

38

54.1%

NZ_FNYB01000021.1:

Lanthipeptides: BMZ34_RS24355_lanthipeptide

3

GADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

37

G DPR+T SF+ASY+ SA+ RCGKDNK K

2

GVDPRTTP-SPLLASFVASYIASAEFRCGKDNKGK

35

51.4%

NZ_LN884299.1:

Lanthipeptides: BN2762_RS08665_lanthipeptide

4

ADPRSTIICSATLSFIASYLGSAQTRCGKDNK

35

A+ RST++C +SF+ASYL SA +CGKDNK

5

AEVRSTLLCGMGISFVASYLASAAFKCGKDNK

36

51.4%

NZ_NVMQ01000017.1:

Lanthipeptides: CON32_RS17790_lanthipeptide

3

GADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

37

G DPR+T SF+ASY+ SA+ +CGKDNK K

2

GVDPRTTP-SPLLASFVASYIASAEFKCGKDNKGK

35

48.6%

NZ_KN125582.1:

Lanthipeptides: DJ91_RS27545_lanthipeptide

3

GADPRSTIICSATLSFIASYLGSAQTRCGKDNK

35

G PR+T + SF+ASY+ SA+ RCGKDNK

2

GVTPRTTPATTLLASFVASYIASAEFRCGKDNK

34

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.70 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.81 out of 30.25

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.84 out of 26.06

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.71 out of 20.97

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.19 out of 19.26

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.04 out of 24.78

Confidence: medium

Additional weak hits (5):

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.04 out of 30.11

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.16 out of 23.43

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.23 out of 33.73

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.27 out of 25.75

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 17.35 out of 30.12

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

EQH27_RS09735 - Class II

Cleavage pHMM score: -0.40

RODEO score: 0

Monoisotopic mass: 4313.2 Da

Molecular weight: 4315.8 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4333.9 Da N = 1; 4351.9 Da N = 2; 4369.9 Da N = 3; 4387.9 Da N = 4; 4405.9 Da N = 5; 4424.0 Da N = 6; 4442.0 Da N = 7

EQH27_RS09740 - Class II

Cleavage pHMM score: -1.30

RODEO score: 0

Monoisotopic mass: 3741.0 Da

Molecular weight: 3743.2 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3761.2 Da N = 1; 3779.2 Da N = 2; 3797.3 Da N = 3; 3815.3 Da N = 4; 3833.3 Da N = 5; 3851.3 Da N = 6; 3869.3 Da N = 7

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
CcpA	Catabolite control protein A
ColR	Phenol-responsive regulator
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes

NZ_CP035253.1 - Region 7 - RiPP-like

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Location: 1,923,454 - 1,933,750 nt. (total: 10,297 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

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Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0001638.4	0.40	ribosomal	klebsazolicin	Klebsiella pneumoniae subsp. ozaenae
BGC0000571.3	0.36	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0000513.3	0.36	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000551.5	0.36	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000504.5	0.36	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0002698.2	0.35	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000501.3	0.35	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000500.5	0.35	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0001638.4	0.40	ribosomal	klebsazolicin	Klebsiella pneumoniae subsp. ozaenae
BGC0000571.3	0.36	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0000513.3	0.36	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000551.5	0.36	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000504.5	0.36	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0002698.2	0.35	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000501.3	0.35	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000500.5	0.35	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

Additional weak hits (1):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.05 out of 28.14

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ToxT	Regulator of MSHA biosynthesis