LOCUS       NZ_CP035253            22991 bp    DNA     circular CON 19-DEC-2024
DEFINITION  Streptococcus pneumoniae strain TVO_1901933 chromosome.
ACCESSION   NZ_CP035253
VERSION     NZ_CP035253.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 2130843)
  AUTHORS   Rosconi,F., Cotton,S.L., Kempchinsky,A., Surujon,D., Johnston,C.D.
            and van Opijnen,T.
  TITLE     Streptococcus pneumoniae DNA-modification patterns determined at the
            pan-genome level
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2130843)
  AUTHORS   Rosconi,F., Cotton,S.L., Kempchinsky,A., Surujon,D., Johnston,C.D.
            and van Opijnen,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JAN-2019) Biology, Boston College, 140 Commonwealth
            Avenue, Boston, MA 02467, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 05-NOV-2018
            Assembly Method                   :: HGAP v. 4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 299x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022070145.1-RS_2024_12_19
            Annotation Date                   :: 12/19/2024 10:37:21
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,215
            CDSs (total)                      :: 2,141
            Genes (coding)                    :: 1,992
            CDSs (with protein)               :: 1,992
            Genes (RNA)                       :: 74
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 149
            CDSs (without protein)            :: 149
            Pseudo Genes (ambiguous residues) :: 0 of 149
            Pseudo Genes (frameshifted)       :: 69 of 149
            Pseudo Genes (incomplete)         :: 70 of 149
            Pseudo Genes (internal stop)      :: 56 of 149
            Pseudo Genes (multiple problems)  :: 39 of 149
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:26:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1876533
            Orig. end                         :: 1899524
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP035253.1.
            Genome not circularized.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22991
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="6"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22991
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22991
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12991](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12991
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    complement(276..290)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 20.04"
                     /tool="antismash"
     gene            complement(833..2203)
                     /locus_tag="EQH27_RS09695"
                     /old_locus_tag="EQH27_10210"
     CDS             complement(833..2203)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1086: MATE efflux
                     family protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001036275.1"
                     /locus_tag="EQH27_RS09695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_10210"
                     /product="MATE family efflux transporter"
                     /protein_id="WP_001036286.1"
                     /transl_table=11
                     /translation="MNKKRTVDLIHGPILPSLLSFTFSILLSNIFQQLYNTADVLIVGR
                     FLGQESLAAVGATTAIFDLIVGFTLGVGNGMGIVIARYYGARNFTKIKEAVAATWILGA
                     LLSILVMLLGFLGLYPLLQYLDTPAEILPQSYQYISMIVTCVGVSFAYNLFAGLLRSIG
                     DSLAALGFLIFSALVNVVLDLYFITQLHLGVQSAGLATIISQGLSAVLCFYYIRKSVPE
                     LLPQFKHFKWDKSLYADLLEQGLAMGLMSSIVSIGSVILQFSVNTFGAVIISAQTAARR
                     IMTFALLPMTAISASMTTFASQNLGAKRPDRIVQGLRIGSRLSISWAVFVCIFLFFASP
                     ALVSFLASSTDGYLIENGSLYLQISSAFYPILSLLLIYRNCLQGLGQKILPLVSSFIEL
                     IGKIVFVVLIIPWAGYKGVILCEPLIWVTMTVQLYFSLFRHPLIKEGKAILATKVQS"
     gene            complement(2510..3676)
                     /gene="recA"
                     /locus_tag="EQH27_RS09700"
                     /old_locus_tag="EQH27_10215"
     CDS             complement(2510..3676)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008094 - ATP-dependent activity, acting
                     on DNA [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /gene="recA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397020.1"
                     /locus_tag="EQH27_RS09700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_10215"
                     /product="recombinase RecA"
                     /protein_id="WP_001085463.1"
                     /transl_table=11
                     /translation="MAKKPKKLEEISKKFGAEREKALNDALKLIEKDFGKGSIMRLGER
                     AEQKVQVMSSGSLALDIALGSGGYPKGRIIEIYGPESSGKTTVALHAVAQAQKEGGIAA
                     FIDAEHALDPAYAAALGVNIDELLLSQPDSGEQGLEIAGKLIDSGAVDLVVVDSVAALV
                     PRAEIDGDIGDSHVGLQARMMSQAMRKLGASINKTKTIAIFINQLREKVGVMFGNPETT
                     PGGRALKFYASVRLDVRGNTQIKGTGDQKETNVGKETKIKVVKNKVAPPFKEAVVEIMY
                     GEGISKTGELLKIASDLDIIKKAGAWYSYKDEKIGQGSENAKKYLAEHPEIFDEIDKQV
                     RSKFGLIDGEEVSEQDTENKKDEPKKEEAVNEEVTLDLGDELEIEIEE"
     gene            complement(3731..4987)
                     /locus_tag="EQH27_RS09705"
                     /old_locus_tag="EQH27_10220"
     CDS             complement(3731..4987)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000642700.1"
                     /locus_tag="EQH27_RS09705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_10220"
                     /product="competence/damage-inducible protein A"
                     /protein_id="WP_000642707.1"
                     /transl_table=11
                     /translation="MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDN
                     EVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQTLAKFLGKALVFDPQAQEKLDIFFA
                     LRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPMVLN
                     QLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTK
                     ASSQEEANQALDILENQILDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAA
                     AESLTAGLFQATVANFSGVSSIFKGGFVTYSLEEKSRMLDIPAKNLEEHGVVSEFTAQK
                     MAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIGGRSRADV
                     RHIAVMHAFNLVRKALLSD"
     misc_feature    complement(5013..5026)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.7"
                     /tool="antismash"
     misc_feature    complement(5014..5027)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.52"
                     /tool="antismash"
     gene            complement(5072..6088)
                     /gene="brpA"
                     /locus_tag="EQH27_RS09710"
                     /old_locus_tag="EQH27_10225"
     CDS             complement(5072..6088)
                     /codon_start=1
                     /gene="brpA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000239264.1"
                     /locus_tag="EQH27_RS09710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_10225"
                     /product="biofilm formation/cell division transcriptional
                     regulator BrpA"
                     /protein_id="WP_000239282.1"
                     /transl_table=11
                     /translation="MVKKIIGMVLALLSVTVVGVGVFAYTIYQQGTETLAKTYKKIGEE
                     TKVIEATEPLTILLMGVDTGNVERTETWVGRSDSMILMTVNPKTKKTTMMSLERDILTR
                     IESGNGQAHEAKLNSAYADGGAELAIETIQKMMNIHIDRYVMVNMRGLQKLVDAVGGIT
                     VNNILGFPISISDQEEFNTISIGVGEQHIGGEEALVYARMRYQDPEGDYGRQKRQREVI
                     QKVMEKALSLNSIGHYQEILKALSDNMQTNIDLSAKSIPNLLGYKDSFKTIETQQLQGE
                     GEILQGVSYQIVSRAHMLEMQNILRRSLGQEEVTQLETNAVLFEDLFGRAPVGDEDN"
     gene            complement(6096..6614)
                     /locus_tag="EQH27_RS09715"
                     /old_locus_tag="EQH27_10230"
     CDS             complement(6096..6614)
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455540.1"
                     /locus_tag="EQH27_RS09715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_10230"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_000455537.1"
                     /transl_table=11
                     /translation="MEYELLIREAEPKDAAELVAFLNRVSLETDFTSLDGDGILLTSEE
                     MEIFLNKQASSDNQITLLAFLNGKIAGIVNITADQRKRVRHIGDLFIVIGKRYWNNGLG
                     SLLLEEAIEWAQASGILRRLQLTVQTRNQAAVHLYQKHGFVIEGSQERGAYIEEGKFID
                     VYLMGKLIG"
     gene            complement(6604..7047)
                     /gene="tsaE"
                     /locus_tag="EQH27_RS09720"
                     /old_locus_tag="EQH27_10235"
     CDS             complement(6604..7047)
                     /GO_process="GO:0002949 - tRNA threonylcarbamoyladenosine
                     modification [Evidence IEA]"
                     /codon_start=1
                     /gene="tsaE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288243.1"
                     /locus_tag="EQH27_RS09720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_10235"
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     ATPase subunit type 1 TsaE"
                     /protein_id="WP_000275589.1"
                     /transl_table=11
                     /translation="MYIKNEEELQALGERLGHLLAKNDVLILIGELGAGKTTFTKGLAK
                     GLQISQMIKSPTYTIVREYEGRLPLYHLDVYRIEGDADSIDLDEFIFGGGVTVIEWGNL
                     LGDALPDAYLELEILKEADGRRLNFQAKGLRAEKLSEELQYGV"
     gene            complement(7133..7753)
                     /locus_tag="EQH27_RS09725"
                     /old_locus_tag="EQH27_10240"
     CDS             complement(7133..7753)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000839915.1"
                     /locus_tag="EQH27_RS09725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_10240"
                     /product="hypothetical protein"
                     /protein_id="WP_000839908.1"
                     /transl_table=11
                     /translation="MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVS
                     GICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLLINLLGAVLVLSDNLFIKNTLQQEL
                     VDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTIVSL
                     LIYIGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF"
     misc_feature    complement(8023..8036)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.16"
                     /tool="antismash"
     misc_feature    complement(8082..8099)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.23"
                     /tool="antismash"
     gene            complement(8136..8999)
                     /locus_tag="EQH27_RS09730"
                     /old_locus_tag="EQH27_10250"
     CDS             complement(8136..8999)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093609.1"
                     /locus_tag="EQH27_RS09730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_10250"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_001093620.1"
                     /transl_table=11
                     /translation="MNTLAEKFRLKRKELRLSQQTLAEGICEQSQISKIERGHFIPSAD
                     LLFKLSQRLEVPLDYFFNEQIEIKSNLSNFKQLSARLLDDRNYDDLEYIYRIEIERSTF
                     LTLEDRTYLEWIKAIIDFYQYDSKCEAISSLENILLKVSSNTLIYLKALNTLSNFYSLV
                     GREQEYEANYSHLIELYQTKNLDHQEFLFGYIRVRYNYAHYLVSKEKYNEAIQEALETI
                     ELCKQRQTSYQLAPLLILVGNAGAKFLDREQVKNYYIEARELCKIYNNPLMLMKIENYL
                     KELDTV"
     gene            9191..9361
                     /locus_tag="EQH27_RS11015"
                     /old_locus_tag="EQH27_10255"
     CDS             9191..9361
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227862.1"
                     /locus_tag="EQH27_RS11015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_10255"
                     /product="PhrA family quorum-sensing system peptide"
                     /protein_id="WP_001227862.1"
                     /transl_table=11
                     /translation="MRKKRGIKKLVTFALLGVFMFSNTIPYQQFIQKNKQLEIRVQSQK
                     KSNGLDVGKAD"
     misc_feature    complement(9193..9208)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 24.81"
                     /tool="antismash"
     gene            9464..9688
                     /gene="pneA1"
                     /locus_tag="EQH27_RS09735"
                     /old_locus_tag="EQH27_10260"
     CDS             9464..9688
                     /codon_start=1
                     /gene="pneA1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000181087.1"
                     /locus_tag="EQH27_RS09735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_10260"
                     /product="two-peptide bacteriocin subunit PneA1"
                     /protein_id="WP_000181087.1"
                     /transl_table=11
                     /translation="MTNFNSNEKFCGKSLKSLSADEMSLIYGASDGAEPRWTPTPIILK
                     SAAASSKVCISAAVSGIGGLVSYNNDCLG"
     CDS_motif       9464..9550
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTNFNSNEKFCGKSLKSLSADEMSLIYGA"
                     /locus_tag="EQH27_RS09735_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9551..9688
                     /prepeptide="core"
                     /locus_tag="EQH27_RS09735_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-0.40"
                     /molecular_weight="4315.8"
                     /monoisotopic_mass="4313.2"
                     /core_sequence="SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDC
                     LG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTNFNSNEKFCGKSLKSLSADEMSLIYGA"
                     /leader_location="[9463:9550](+)"
                     /alternative_weights="4333.9"
                     /alternative_weights="4351.9"
                     /alternative_weights="4369.9"
                     /alternative_weights="4387.9"
                     /alternative_weights="4405.9"
                     /alternative_weights="4424.0"
                     /alternative_weights="4442.0"
     gene            9695..9883
                     /gene="pneA2"
                     /locus_tag="EQH27_RS09740"
                     /old_locus_tag="EQH27_10265"
     CDS             9695..9883
                     /codon_start=1
                     /gene="pneA2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000786759.1"
                     /locus_tag="EQH27_RS09740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_10265"
                     /product="two-peptide bacteriocin subunit PneA2"
                     /protein_id="WP_000786759.1"
                     /transl_table=11
                     /translation="MKNDFVIGKSLKELSLEEMQLVYGGTDGADPRSTIICSATLSFIA
                     SYLGSAQTRCGKDNKKK"
     CDS_motif       9695..9769
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKNDFVIGKSLKELSLEEMQLVYGG"
                     /locus_tag="EQH27_RS09740_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9770..9883
                     /prepeptide="core"
                     /locus_tag="EQH27_RS09740_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-1.30"
                     /molecular_weight="3743.2"
                     /monoisotopic_mass="3741.0"
                     /core_sequence="TDGADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKNDFVIGKSLKELSLEEMQLVYGG"
                     /leader_location="[9694:9769](+)"
                     /alternative_weights="3761.2"
                     /alternative_weights="3779.2"
                     /alternative_weights="3797.3"
                     /alternative_weights="3815.3"
                     /alternative_weights="3833.3"
                     /alternative_weights="3851.3"
                     /alternative_weights="3869.3"
     gene            10001..12991
                     /locus_tag="EQH27_RS09745"
                     /old_locus_tag="EQH27_10270"
     CDS             10001..12991
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000875571.1"
                     /locus_tag="EQH27_RS09745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_10270"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_000875571.1"
                     /sec_met_domain="DUF4135 (E-value: 4.4e-90, bitscore:
                     299.5, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 4.6e-51, bitscore:
                     170.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKIKNVHKTLFIKERYQILSERNDNSLNNFSLNNWRSTMSIIS
                     EKTFEEMLKLNNYNKKIFSNTVNYDYTEEQIRLYSEYAKNSEWYKFAEGSFEIFRKHPQ
                     RINFKKDFSRILEPFIINLLKLINNYLENKEYEWIDKNGNIFSSLVFYLEDLIYPWIVK
                     PLVLEINSLREKGLLEGESEQQRYKYFITLFDKEENILNFYNKYPVLLRQISESCLRFY
                     TYFIEILSNLENDFSVLEEELGLRGKLNDIKFGKGDTHSQGKTVLILFFDDAKIVYKPK
                     NLIINNSLNTIAEYIRKVDEKIRIRIPRTIAYSDHSYEEFIDYLPLEQKKKLPEYYYNF
                     GVLLAFIYLFNGSDIHFENLISYGDMPVIIDFETMLQQPLFDDKTGQSLLDTLFHRVTR
                     TLLLPTEGVKREDGLDVEMSALTGNFKKDAFNGQVLINLNTDKVKFDIGKIDFEGGKNL
                     PVRDGDIEFDKYIKDFKKGFRDFYLIFEELNKTEEFKMLLKANLYGLKTRVLFRDTNSY
                     ASVLSFLYHPDFYEEMLDREKALENLWSNKFSNQGIVASECEQMRLLDIPIFYTDTNIN
                     EIYDDFGNHFISLHQFSGYDYFMKYLPNNNLENLEKQLDIIEIYFPSFDQRKKGYKLNL
                     SNRKKLPNESLVTILHNEVENIADSLVINNIYDEYPIWSIPVNFKGSKWCLEQTGNDMY
                     RGRAGILLFMYYVKLLKDKSSYTQLYNKMLSAIPPSVSLSKTTFGLTGDIGYFIVLSII
                     EDYDTNTLACLNYIKSVLTELEKTDFASVSNKSDYINGLLPLINTLVRYYRRGIEKERV
                     LRLVLSLGDTLYNDVSERDNSNFGYSFGHGLSGVIFTLKNIYKVTRLKKYKELILQLVP
                     REKIKIHSLKWCSGEFGTLVNHPQSVPEGIVASLDNDTFCHGSMAIINFYIDYMKEMDT
                     SMELESLLCSVVMNKSKEGEYRIVQTSNFPDFSLYTGVTGIAYTFLRYIALNQNDKKIV
                     IPSLLEI"
     misc_feature    13191..13204
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.84"
                     /tool="antismash"
     gene            13341..14045
                     /locus_tag="EQH27_RS09750"
                     /old_locus_tag="EQH27_10275"
     CDS             13341..14045
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001033172.1"
                     /locus_tag="EQH27_RS09750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_10275"
                     /product="flavodoxin family protein"
                     /protein_id="WP_001033170.1"
                     /transl_table=11
                     /translation="MNKIFIYAGVRNHNSKTLEYTKRLSSIISSRNNVDISFRTPFNSE
                     LEISNSDSEELFKKGIDRQSNADDGGVIKKELLESDIIIISSPVYLQNVSVDTKNFIER
                     IGGWSHLFRLAGKFVVTLDVAESNGSDNVSEYLRDIFSYMGGQILHQVSITNSLKDIAE
                     AQLMEATYKIEDVLEGKIKYKTTDYQERAYQTLKLILENYDSEHFEKMYWEKKRLFEAN
                     SLEEWYYVENIK"
     gene            14026..14955
                     /locus_tag="EQH27_RS09755"
                     /old_locus_tag="EQH27_10280"
     CDS             14026..14955
                     /EC_number="3.4.24.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000912951.1"
                     /locus_tag="EQH27_RS09755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_10280"
                     /product="M50 family metallopeptidase"
                     /protein_id="WP_000912954.1"
                     /transl_table=11
                     /translation="MLKILNNSVIYLCLIPLLFLLLIIFPNDSLIYYFRLILISLISIT
                     LHELGHFLVGRCLSYKLEMLATPFFFYFRKKIYFKFPVLLAFGYCQMSNRNITNEKNSD
                     RNLVFYFFGGGGANLIVAILALLGFVPYASEFFILNIILFLVTVCLPIDGTDGNAIREI
                     VLYSKDSKTYQRFFANSLYNNPYITIDDFAKLTSKEKSFFSKFEKCLINLYFEVKGEGS
                     AFTIANHEVFDSNIQENIIHEYYKLLHKSSDWIIPQNLSLEEVVFTLSNYIYSKNNKYL
                     EKIKYLKKLVDFRQEEIIDFILNKEEVL"
     gene            14952..17060
                     /locus_tag="EQH27_RS09760"
                     /old_locus_tag="EQH27_10285"
     CDS             14952..17060
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000701297.1"
                     /locus_tag="EQH27_RS09760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_10285"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_000701299.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 4.9e-37, bitscore:
                     123.7, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIPMIYQMENSECGLACCAMILNYFKYEISLNELREIYPSSRSG
                     YSLLSISKVLGDFNISSHAFKASVRDLKPLSFPLICFWESSHFIILEKISKNKFYILDP
                     AKGRQRMSISEFERHYSNIILTFKKLDSFMSRKDNKKSPVLKYFFKYRNKLGILFFVTA
                     LLYVIQSLVPIANRYIIDTNFKDDSYSSRMLFTILFIFTVSFSLMYLLRQIYVASLKYI
                     MDKEISYDFMKHLIYLPYSFYEKRTLGDILFRANSIVYIREILSNNFIAAILDLLMIVV
                     YAVVLFSFSKYMVIFLISLSLALSIVMYPIIKISKNLIDKNIKEKVNVQNITSEVISKN
                     SDIKLTGEEEFWINKWDNFNTKQLIIGRKLDIHLSIVSSITNVLQIILPVLTLIVGVNI
                     KTFEQLTLGQIVAISTVSPYFISPIISLSDNYIQLMLLKGYFLRIEDVFNTKSELIPER
                     VSQDIKFDKKIKLKDIWYKYGLFDDYVLKGINVTIKKGETVAIVGESGSGKSTLAKILL
                     GLLEPNIGSIEVDGVEKEEIGQTLYRKIFGAVLQNSTLSYGTLRENLTFGHFVSDEELM
                     TNLNSIGLSNVVKSLPLGLETIIAEEGNNFSGGQQQMILLARCLLSKPSVVVLDEATSS
                     LDNLSQQITTSYLSEIGTTKILIAHRLDTIKSADKILVMHNGEIVEIGTHRELLELGGI
                     YKQLYSNN"
     gene            17084..18823
                     /locus_tag="EQH27_RS09765"
                     /old_locus_tag="EQH27_10290"
     CDS             17084..18823
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000699970.1"
                     /locus_tag="EQH27_RS09765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_10290"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_000699969.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 3.1e-37, bitscore:
                     125.4, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIMKKKYWTLAILFFCLFNNSVTAQEIPKNLDGNITHTQTSESF
                     SESDEKQVDYSNKNQEEVDQNKFRIQIDKTELFVTTDKHLEKNCCKLELEPQINNDIVN
                     SESNNLLGEDNLDNKIKENVSHLDNRGGNIEHDKDNLESSIVRKYEWDIDKVTGGGESY
                     KLYSKSNSKVSIAILDSGVDLQNTGLLKNLSNHSKNYVPNKGYLGKEEGEEGIISDIQD
                     RLGHGTAVVAQIVGDDNINGVNPHVNINVYRIFGKSSASPDWIVKAIFDAVDDGNDIIN
                     LSTGQYLMIDGEYEDGTNDFETFLKYKKAIDYANQKGVIIVAALGNDSLNVSNQSDLLK
                     LISSRKKVRKPGLVVDVPSYFSSTISVGGIDRLGNLSDFSNKGDSDAIYAPAGSTLSLS
                     ELGLNNFINAEKYKEDWIFSATLGGYTYLYGNSFAAPKVSGAIAMIIDKYKLKDQPYNY
                     MFVKKILEETLPVKNGIKVLNIPNVLRYDLNMLQLEYKNEQSWDSFIDNVNLIELEERI
                     QTTIGIKQINTHNIITIAREGYSQNYLPNTSENTYNSLQVSLVGVLLLFISMVNILWAK
                     KSK"
     gene            18874..19641
                     /locus_tag="EQH27_RS09770"
                     /old_locus_tag="EQH27_10295"
     CDS             18874..19641
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677041.1"
                     /locus_tag="EQH27_RS09770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_10295"
                     /product="DUF1430 domain-containing protein"
                     /protein_id="WP_001857677.1"
                     /transl_table=11
                     /translation="MSQKMNHLDVGEFVLLLPEHLRSEEEHYKSVFEDDLTSRMSSQDE
                     RQQMTATVGYLESGQDRFVYNTTPISYQQFLKDPIIIVITPQSTGPQSILFWIDAVQNY
                     VLFNQLSDAQELIQRQGIENWVSEMQTGYHNYITLLDNIQRERWVMLAGAVLGIATSIL
                     LFNTMNRLYFEEFRRAIFIKRIAGLRFLEIHRTYLFAQLGVFLLGFVASVFLQVEIGVA
                     FLVLLLFTGLSLLQLHVQMQKENKMSMLVLKGG"
     gene            19643..20275
                     /locus_tag="EQH27_RS09775"
                     /old_locus_tag="EQH27_10300"
                     /pseudo=""
     CDS             19643..20275
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260353.1"
                     /locus_tag="EQH27_RS09775"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_10300"
                     /product="ABC transporter ATP-binding protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MIELKQVSKSFGERELFSNLSMTFEAGKVYALIGSSGSGKTTLMN
                     MIGKLEPYDGTIFYRGKDLANYKSSDFFRHELGYLFQNFGLIENQSIEENLKLGLIGQK
                     LSRSEQRLRQKQALEQVGLVYLDLDKRIFELSGGESQRVALAKIILKNPPFILADEPTA
                     SIDPATSQLIM"
     gene            complement(21203..21616)
                     /gene="ndk"
                     /locus_tag="EQH27_RS09780"
                     /old_locus_tag="EQH27_10305"
     CDS             complement(21203..21616)
                     /EC_number="2.7.4.6"
                     /GO_function="GO:0004550 - nucleoside diphosphate kinase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="ndk"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000438285.1"
                     /locus_tag="EQH27_RS09780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_10305"
                     /product="nucleoside-diphosphate kinase"
                     /protein_id="WP_000438288.1"
                     /transl_table=11
                     /translation="MEQTFFIIKPDGVKRGLVGEVLKRIEQRGFTIEKLEFRSQVSEEL
                     IDQHYQDLVGQSFYPPIREFMTSGPVLVGVISGPKVIETWRTMMGATRPEEALPGTIRG
                     DFAKAAGENDIIQNVVHGSDSEESAKREIALWF"
     misc_feature    complement(21601..21614)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 21.04"
                     /tool="antismash"
     misc_feature    complement(21901..21912)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.71"
                     /tool="antismash"
     misc_feature    complement(22040..22054)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 17.35"
                     /tool="antismash"
     misc_feature    complement(22716..22731)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.19"
                     /tool="antismash"
     misc_feature    complement(22772..22784)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.27"
                     /tool="antismash"
ORIGIN
        1 atggataagg gtcaacgtgg tctgagtggt tgtttggttg gttattcgtg caatactcgt
       61 gcgttttaat tccagctaaa ctccctgtat caagcgtttt cggcaaacct gcttcatctg
      121 ctagattgcg taagagttcg atataaaggc ggtagtccgt catgaactct tctttggttg
      181 aatggctttc aatcagttca accgctgcat aggtctcagc attccaaccg cccccaacgt
      241 cccaggcacc attatcaaca ggtcctacct gcatgatgca accgttccca acaatgtgcg
      301 agaaaaaacc taattctggg tctttccgcc agtgataatc cgcttcattc tgtacggttg
      361 aatgcggatt cccagttgag tgtgcgtgta cttgcctata tggttgcacg ccgacttgag
      421 gcaaatctgt tcttaattta ctcacattaa tttccatatt ctactcctta tcaattaaaa
      481 caactcattt tttacaatcc agaaccagaa actcctttat ttctacctta caaagaagac
      541 aatcttagtc acgattaggc ttgtagatag aacttcaaaa cgcactattt tgacactgta
      601 aataggactg acaaggtctg cattctatct acaataacac cccagactaa aaagcttttc
      661 aaaagtatat ttttacagtc tctatatgtc cttttcataa atactatact ttattatatc
      721 atataaaaga agtcaaaagt ctgttaaact attttcaaca ccaaactaaa gaagagaaca
      781 caagtttttt cgattttcac tagaggaaat ggattttatt cagtaaatcc aactaggatt
      841 gcactttggt tgccaaaatt gcctttcctt cttttatcaa gggatgacgg aatagtgaga
      901 agtacagttg aactgtcatg gtaacccaga taagaggttc acaaaggata acacccttat
      961 atcctgccca aggaataatc aaaaccacaa aaacgatttt tccgattagt tcaataaagc
     1021 tagaaactag aggaaggatc ttctgcccca agccctgcaa gcaattgcga taaatcaaca
     1081 agaggctcaa aatgggataa aaggctgaac tgatttgcag atagagactt ccattttcta
     1141 tcaagtaacc atctgtcgaa ctagccaaga aggaaaccaa ggctggactg gcaaaaaaga
     1201 ggaaaataca aacaaaaact gcccaggata tacttaaacg actgccgatt cgaagacctt
     1261 gaacaatgcg gtcaggtcgc ttagctccta gattctgaga agcaaaggtc gtcattgatg
     1321 cagaaatagc ggtcatagga agaagggcaa aggtcataat gcgtcgagct gccgtctggg
     1381 cactaataat cactgcacca aatgtattaa cagaaaactg taaaatcaca ctgccgatag
     1441 atacaattga actcatcaag cccatagcca aaccttgctc caagagatcc gcgtacaagc
     1501 ttttgtccca tttgaaatgt ttaaactgtg gcaagagttc tggcacactt ttacgaatat
     1561 aataaaagca gagaaccgct gataaacctt gcgaaataat ggtagcaagt cctgcggatt
     1621 gaactcccag atgcaattgc gtaataaaat agagatccag aaccacatta accaaggcag
     1681 agaaaatcag aaatcccagg gctgctagac tgtcaccaat agaccgcaac aagcctgcaa
     1741 aaagattata agcaaagctg acacctacac aggtcacaat catagaaata tattgataag
     1801 attgaggaag aatttctgca ggagtatcta agtattgcaa gagaggatac aagccaagaa
     1861 agcccagcaa cataactaga atgctcaaaa gagcacctaa aatccaagtg gctgctactg
     1921 cttccttgat tttagtgaaa ttccgagccc cataataacg agcaatgaca atccccatgc
     1981 cattgccaac accaagtgta aaacctacaa tcaggtcaaa aatcgctgtc gtcgctccta
     2041 ctgcagccaa ggattcttga ccaagaaatc gtccaacaat caagacatca gcagtgttat
     2101 agagctgttg aaaaatattt gatagcaaga ttgaaaaggt gaagcttaag agcgagggaa
     2161 gaatcggacc atgtatcagg tccactgttc gttttttatt cataaagcta ttatatcagc
     2221 tttccagagg agcgacaaga aacagcaaac ttatatatag cggaatgaaa taaggacagt
     2281 caaatcgatt tttaacaatg ttttagaagt agatgtgtac tattctagtt tcgatctatt
     2341 atagttggtt gagtttggaa tattacgctg tagctgctaa aacatttcta caaattaatt
     2401 tgactttcct aataaagttg ttcatatctt atttcaagct actatatata atctaaaaac
     2461 ttgaatcaaa aatcgaaaaa gtagcggatt tttccactgc tttaacagct tattcttcaa
     2521 tttcgatttc aagttcatcg cctaagtcaa gcgtaacttc ttcattcact gcttcttctt
     2581 tctttggctc atcttttttg ttttcagtat cttgttctga aacttcttct ccatcaatca
     2641 agccaaattt agaacggact tgcttatcaa tttcatcaaa gatttctggg tgctctgcca
     2701 agtatttctt agcattctca gaaccttgcc caattttttc atctttgtaa gaataccaag
     2761 cccctgcttt tttgataata tccaaatcgc ttgcaatctt caaaagctca ccagtcttag
     2821 aaattccttc tccgtacata atttcaacta cggcttcctt aaacggtgga gctaccttat
     2881 tttttacaac cttaatctta gtttctttac cgacattggt ttctttttgg tcaccagttc
     2941 ccttaatttg tgtattacca cgaacatcca agcggactga agcatagaat ttcaaagcac
     3001 gtccgcccgg tgttgtttct ggatttccaa acatcactcc aactttttca cgcaattggt
     3061 tgataaaaat ggcaattgtt ttggttttat tgatagaggc gccaagttta cgcatggcct
     3121 ggctcatcat acgagcctgc aaaccaacat ggctatctcc gatatctcca tcaatttccg
     3181 cacgaggaac aagggcagca actgagtcga ctacgacaag atcaactgca cctgagtcaa
     3241 tcaattttcc cgcaatctca agaccttgct ctcctgagtc tggttgagac aagagcaatt
     3301 cgtcaatatt gacaccaagg gccgcagcat aagctggatc aagggcatgt tccgcatcga
     3361 taaaggcagc aatcccacct tctttttgcg cttgtgcaac tgcatgaagg gcaaccgttg
     3421 tcttaccaga tgactctggg ccatagattt cgatgatacg tcccttagga taaccacctg
     3481 agccaagggc aatgtcaaga gctaaagaac ctgagctcat cacttgcacc ttttgctccg
     3541 cacgttcacc caaacgcatg attgatcctt taccaaagtc tttctcaatc aatttaagag
     3601 cgtcattcaa ggccttttca cgttctgccc caaatttttt tgaaatttct tctaattttt
     3661 ttggtttttt cgccattcta ttctcctaca ttctaatgat cctcagacct atctactatt
     3721 atatcaaaag ttagtcactt aataaagcct tgcgaactag gttaaaggca tgcataaccg
     3781 caatgtgacg tacatctgct cggcttctgc ctccaatatt aaccttgata acctcagttc
     3841 cttgatcttg cgccaagcct atgaagactg tcccaactgg gtgtccttct aggctatctg
     3901 gtcctgccac tccagtcaaa ctaattccaa aatcagactg ggtcttgctt cgtgcctgct
     3961 cagccatctt ctgagctgta aattcagaca ccacaccatg ttcttccaaa ttcttggcag
     4021 gaatatccaa catccttgat ttttcctcca agctataggt cacaaaacca cccttaaata
     4081 tacttgaaac tccagaaaaa ttcgccacgg tagcttggaa aagacctgcc gtcaaactct
     4141 ctgcagccgc gatggttttc ccttgccttt tcagttcttc taccacaatg ctggctaaac
     4201 tagtttcttc cccataacca tagcaaaagt ctcgtaaaga aattccttcg aaagtctggc
     4261 agtccaagat ttgattttcc aagatatcca gcgcttgatt cgcctcttct tgactgctag
     4321 cctttgttga cagacgtaga gtgacttctc ctgtcttggc ataaggggcc aaggtaggat
     4381 cgatctgatt atcaattaaa tcagccaaaa tcgtaaccaa ctggctctcg ccaatcccaa
     4441 agaaacgaag aactcgggaa tacagcttgc tccctgtcat caacttgggt agaagttggt
     4501 ttaagaccat gggtttcaat tcacttggcg gacctggaag gacgacatag gtcactccgt
     4561 ctacttctaa ttttcctcca acagccagtc ctgtttcgtt tggcagtgga atcgctcctt
     4621 ctacaatttg agcttgtctt tcgttattcg gtgttcgggc atagtctggt cgcagggcaa
     4681 aaaagatatc caacttctcc tgagcctgag gatcaaagac taatgctttc cctaaaaatt
     4741 tagctagggt ttgtttggtt aggtcgtcct cagttggccc caaaccgcct gtcaaaatca
     4801 ccagactgct acgttgactg gcaatctcaa gcaaagacaa gagacgaact tcattgtctc
     4861 ctacagccgt ctgaaaatat acatctaccc caatctcagc tagtttttcc gacaaaaact
     4921 gggcattggt gttgacaatc tgtcctgtca aaatctctgt tccaacagca atgatttctg
     4981 ctttcatgtt tcctcctacc tatctattcg tatttttttg aaaaaatcgc aggaattttc
     5041 ctacgattga tttttttatt tgtatcaaaa gttaattatc ttcatcacca acaggtgctc
     5101 tgccaaataa atcttcaaat aaaaccgcat tggtttcaag ctgagtaact tcttcttgtc
     5161 ccaaagaacg tcggagtata ttttgcattt ccaacatatg tgctctcgaa acaatctggt
     5221 aagaaacacc ttgaagtatc tctccttcac cctgcaactg ctgagtttca atggttttaa
     5281 atgaatcttt atagcctagc aagttaggga tactttttgc agacaaatca atattggtct
     5341 gcatattgtc actcaaagct tttagaatct cttgataatg accaatgcta tttaaactga
     5401 gagctttttc catgactttt tgaataactt cacgttgacg tttttgacga ccataatccc
     5461 cctcaggatc ttggtaacgc attcgtgcat agactagggc ttcttctccc ccaatatgtt
     5521 gctccccaac accgatagaa atggtattaa attcttcttg gtcactgata gaaattggga
     5581 aacctaggat attattgact gtaatacctc ctactgcatc cactaatttt tgcaaccctc
     5641 tcatattgac catcacatag cgatcaatat ggatattcat cattttttga atggtttcta
     5701 tagcaagctc tgctccacca tctgcatatg ctgagttcag tttcgcttca tgagcctgac
     5761 cattccctga ttcaatgcgc gtcagaatat cccgctctaa actcatcatt gttgtttttt
     5821 tcgttttagg attcactgtc atcaagatca tgctatcact tctaccgacc caagtttcag
     5881 ttcgttcaac atttccggtg tccactccca ttaacagaat ggttagaggt tcagtcgctt
     5941 caataacctt ggtttcttcg ccgatttttt tataggtttt agctaaggtt tctgtccctt
     6001 gttgataaat agtataagca aaaacaccta ctcctactac agttacagaa agtaaagcta
     6061 gcaccattcc aataattttt ttaaccatat ttctactaac ctatcagttt acccatcaag
     6121 taaacatcga taaatttccc ttcttctata tatgccccac gctcttggct accttcaatg
     6181 acaaagccat gcttttgata aagatggact gctgcttgat tacgagtttg gacagtcagt
     6241 tggagacgac gcagaatgcc acttgcttgt gcccactcta tcgcttcttc tagcaacaaa
     6301 cttcccaagc cattattcca atatcttttt ccaatcacaa tgaagagatc tccaatatga
     6361 cggactctct tacgctgatc agctgtaata tttacaatac cagcaatttt gccatttaag
     6421 aatgcaagta aggttatctg attgtccgaa ctagcttgct tgttgaggaa tatttccatc
     6481 tcctcactag tcaagagaat accatctccg tctaggctgg taaagtctgt ctccaaactc
     6541 acacgattta aaaaggccac taattcagct gcatctttgg gctctgcttc cctaatgagc
     6601 aattcatact ccatattgaa gctcctctga caatttctca gcacgcaaac cctttgcctg
     6661 aaaatttaaa cggcgtccat ctgcttcttt tagaatttcc aattctaaat aagcatctgg
     6721 caaggcatct cctaagagat ttccccactc aataacagtc acgccgccac caaagataaa
     6781 ctcatccaag tcgatagaat cagcatctcc ttcaatacga taaacatcta ggtgataaag
     6841 tggaagtcga ccttcatact ctctcacgat agtataggta ggacttttaa tcatttgaga
     6901 aatctgtaat ccttttgcaa gtcctttagt aaaggtcgtt ttacctgcac ccagttctcc
     6961 aattaagatt aaaacatcat tctttgctaa tagatggccc aaacgctccc ctaaggcttg
     7021 caactcttct tcatttttta tgtacatact cttattatac caaaaacttt tcttttgtgt
     7081 ctattttcct actaaactta tcatcataac atccataaaa aacaggcttt ctctaaaaga
     7141 aaatgagcgt aacaatgacc aatacaagat ctcggaaaat atgaccataa aaggaaactt
     7201 ccttcttaac cgaatttggg acaagatagg ctgcaaaaaa caagcccagt ccaatataaa
     7261 tcagaagtga gacaatggtc attggatttc ttaagaaaag aagtgttgct aaaatagtca
     7321 ccaacactgt cttttttctg tctagcatag caagaaaatc gcgcacgtat tttttcaagg
     7381 gtaaaaaaat cagcaaatct agcccaaata ggaaaaagaa ggatggcaat aaaaagtcaa
     7441 ctaattcttg ctgcagcgta tttttgatga acaagttatc tgacaaaaca agaacagctc
     7501 ctaacaaatt aattaagagt aacatactgt aaaaaagctt caccgacttc ttactggcta
     7561 ggacactatg gacttcttgc ttacgggtat aaagataatt tactccagca cagattcctg
     7621 aaacgaaaac catgcttccg atgaaaaaag ctgtactttg tttaaaggac aagatgcatt
     7681 ccttccataa gaaacagcta ctcaaactga tttgaattaa agctaacaaa aataagattc
     7741 tcattgattt catcttctct ctcccttcct accaatcatt atactaggag aaaagagaga
     7801 actgtttcta atcttctcaa atgtctcttt aagacgctaa acaaacacta gagactaata
     7861 ctcaatgaaa atcaaagatc aaactaggta gctagccaca ggttgctcaa aacactgttt
     7921 tgagattgca gatagagctg acgtgatttg aagagatttt cgaagaatat aaatttgaaa
     7981 tcatgaaaat ccgtcaaacg ggtggttgtt ttgtctcgca cctcacggag cgagacggac
     8041 tcagagtcac ataattataa ggctgatagt attaatctaa ctatcagcct tacaggttat
     8101 ttaacgtttc agaaaaacta taatgtcaag attaactaaa cagtatctag ttccttcaaa
     8161 taattttcta tcttcatcaa cattaaagga ttgttataaa tcttacataa ctctcttgct
     8221 tctatataat aatttttgac ttgttctctg tctagaaatt tggctccagc atttcctaca
     8281 agaataagta gaggagccaa ttggtagctt gtctgtcttt gtttacagag ttcaatcgtt
     8341 tcaagagctt cttggatggc ttcattatat ttttcctttg atactaggta gtgagcgtag
     8401 ttgtaacgaa ctctgatgta gccaaataaa aactcttgat ggtccaaatt ttttgtctga
     8461 tacaactcta ttaaatgaga gtagtttgcc tcatattctt gttcacgacc cactaaggaa
     8521 tagaaattag atagagtatt caacgccttt aaataaatca gagtatttga agagactttt
     8581 aataatatat tttccaatga agaaattgcc tcacacttac tgtcatattg atagaagtca
     8641 ataatagctt taatccattc aaggtaagtt cggtcttcta gtgttagaaa agtacttcgt
     8701 tcaatctcta ttctataaat atattccaaa tcgtcataat ttctatcgtc taatagtcga
     8761 gcagacaatt gcttgaaatt agagaggtta gatttaattt caatttgttc attaaaaaaa
     8821 taatctaatg gtacttcaag tcgttgagag agtttgaaca aaaggtctgc ggagggaatg
     8881 aaatgccctc tctcaatttt actaatctgg ctttgttcac aaattccttc tgcaagagtt
     8941 tgttgggaga gtctcaactc ttttcttttc aatctgaatt tctctgcgag tgtattcatt
     9001 aaagataata aaccttccta tttgcttaat ttcattataa agtttttagt tcaaaatagc
     9061 aagttaaagg aataaataat tctttatggt aataaacaaa aaaaaaagtt aaaaattaca
     9121 taaaaatact tgactaaata aaatatatct gttagaataa aaacaaggaa aaagaaaggg
     9181 gtttcattgc atgagaaaaa aacgtggaat taaaaaatta gttacatttg cattgctagg
     9241 tgtttttatg tttagtaata caattcctta ccaacagttt attcagaaga ataaacaatt
     9301 ggagattcga gtgcaatcgc aaaagaagtc caatggtctt gatgttggga aggcggatta
     9361 aaacccgata ttttgcacga gaatgagaga attataattt atctgaaaaa acgaaaaata
     9421 tagagcaact tatttaactt tttataagga ggagttatta cttatgacca actttaattc
     9481 aaacgaaaaa ttttgtggaa aaagtttaaa atcattgtct gctgatgaaa tgagtttaat
     9541 ttatggtgca tctgatggtg cagagccacg ttggacgcct actcctatta ttttgaaatc
     9601 agctgcagct agctcgaaag tatgcattag tgcagctgtt tctggtattg gggggctagt
     9661 tagctacaat aatgattgtt tggggtaaat taaaatgaaa aatgattttg taatcggaaa
     9721 gagtttgaaa gaattatctc ttgaagaaat gcaattggtt tatggtggca cagatggtgc
     9781 tgaccctaga tcaacaatta tatgttctgc tacattaagt tttattgcat catatttggg
     9841 gtcagctcag actcgttgtg gcaaagacaa caagaaaaaa taaaatattc aattttaaaa
     9901 ataaaagttg ctctttattt tcctctctcg taactaataa ttttgagaga ggtttttttt
     9961 tttaaaacaa tagtaagtcg tataggtttg aggtaagtaa atgaaatata aaattaaaaa
    10021 tgtgcataaa acattgttta ttaaggaaag atatcaaata ttatctgaac gaaatgataa
    10081 ttccttaaat aacttttcat taaataattg gcgttctaca atgtcaatta tttctgaaaa
    10141 aacttttgaa gaaatgttga aattaaataa ttacaataaa aaaatatttt ctaacactgt
    10201 gaactatgat tataccgagg aacagataag actatattca gaatatgcca aaaattcgga
    10261 atggtataaa tttgcggagg gttcatttga aatatttaga aaacatcccc aaagaattaa
    10321 ttttaagaaa gatttttcta gaattttgga accctttatt attaatttgc ttaaattaat
    10381 caataattat ctagagaata aagaatacga gtggattgac aagaatggaa atattttttc
    10441 ctctctagta ttttatttag aagatttaat ctatccttgg attgttaaac ctttggtttt
    10501 agagataaat tcattgcgtg aaaaaggttt acttgaaggg gaatcggagc agcaacggta
    10561 caaatatttt ataacattgt ttgacaagga agagaatata ttaaattttt ataacaaata
    10621 tcccgtttta ctgaggcaaa tatcggagtc ttgtcttcgg ttctatactt attttataga
    10681 aattttatca aatttagaaa atgattttag tgtgctagaa gaagaattag ggctaagggg
    10741 gaaattaaat gatataaaat ttggaaaggg tgatacacac agccaaggaa aaactgtttt
    10801 gatactcttc tttgatgacg cgaaaattgt ttacaagcct aaaaatttaa taatcaataa
    10861 ctcactaaat actattgctg agtatatccg aaaggttgat gaaaaaatta ggataagaat
    10921 acctcgaact attgcttatt cggatcacag ctatgaagaa tttattgatt atctacctct
    10981 agagcaaaag aaaaaattac ctgaatatta ttataatttt ggtgtgcttt tagcatttat
    11041 atatttattt aatgggagtg atatacattt tgaaaattta atttcctatg gagatatgcc
    11101 tgtaataata gactttgaaa caatgttaca gcaacctcta tttgatgata aaactggtca
    11161 gagtttgctg gataccctgt ttcacagggt gactcgaact ttgcttcttc caacagaggg
    11221 agtaaaaagg gaggatggtc ttgatgttga gatgagtgct cttacaggaa attttaagaa
    11281 ggatgctttt aatggtcaag ttttaattaa tttaaatact gataaggtaa agtttgatat
    11341 tgggaaaatt gattttgaag gtgggaaaaa cctgcctgtt cgggatggtg atatagaatt
    11401 tgataagtat ataaaagatt tcaaaaaagg ttttagggat ttttatctga tatttgaaga
    11461 gttaaataaa acagaagaat ttaaaatgct attaaaagca aacttgtatg gtttaaagac
    11521 aagggtactt tttagagaca caaatagcta tgcttcagta ctatcttttt tatatcatcc
    11581 tgatttttat gaagaaatgt tagatagaga aaaagcattg gaaaatctct ggagcaataa
    11641 gttttctaat caaggtattg tagcaagcga atgtgaacaa atgaggttat tagatattcc
    11701 gattttttat acagatacaa atatcaatga aatctacgat gattttggaa atcattttat
    11761 ttccctacat caattttctg gatatgacta ttttatgaaa tatttaccta ataataattt
    11821 ggaaaattta gaaaagcaac ttgatatcat tgaaatttat tttccaagct ttgatcagcg
    11881 aaaaaaagga tataaattaa acttatctaa tagaaaaaaa ctcccaaatg aaagtttagt
    11941 tactattctg cataatgaag tagaaaatat tgcagactct ttggttatta ataatattta
    12001 tgacgaatat ccaatttgga gtatacctgt taattttaaa ggttctaaat ggtgtcttga
    12061 acaaacgggt aatgatatgt ataggggtag agctggaata ttactgttta tgtactatgt
    12121 aaaattattg aaagataaat catcatatac tcaactgtac aataaaatgt tatctgcaat
    12181 tccgccatct gtttctttat ctaagaccac atttggttta actggggata taggatattt
    12241 cattgttcta tccattatag aggattacga tacaaatact ctcgcatgct taaattatat
    12301 aaagagtgtt ttaactgagc ttgaaaagac tgattttgca agtgtttcaa acaagtctga
    12361 ctatattaat ggtcttctac ctttaattaa tacactggta agatattata ggagaggaat
    12421 agagaaggaa cgtgttctaa ggctagtatt aagtttaggt gatacgctat ataatgatgt
    12481 aagcgagaga gataatagta attttggata tagttttggc catggactat caggtgtaat
    12541 ttttacatta aaaaatattt ataaagtgac aagacttaaa aaatataaag aattaatttt
    12601 acaactagtt cctagggaga aaatcaaaat tcattctttg aagtggtgta gtggagaatt
    12661 tgggacatta gttaatcatc cccaaagtgt tccagaggga attgtagcta gtttagataa
    12721 tgatacattt tgccatggaa gtatggccat aataaatttt tacatcgact acatgaaaga
    12781 aatggatact agtatggaat tggagtcttt attgtgtagt gttgtaatga ataaatcaaa
    12841 agaaggagag tatcgtatcg tccaaacaag caatttccca gatttttctt tgtatacagg
    12901 tgtgactggt attgcttata cttttttaag gtatatcgca ctgaatcaga atgacaaaaa
    12961 gatagttatc ccctcattac ttgaaatcta gcttaattta tagttttgtt tctaaaatag
    13021 aggtgtccac tcattaagca atataaaaat accaagattg actagtttaa tatgtaattc
    13081 tataaaatat ttttaatagt gtagcttttc gttgagataa taatataata aagaaaggtt
    13141 ctattctaat tgctaaacgg cttgaggtat atgctactgt tatagaaatg attttaaact
    13201 aaaatcaaaa ttactccaaa aatagtattg attttggttt aatacaaaac atatgtaata
    13261 atgtgagtca acaaaagtct gtttttgtac catactatct tgaaaaatct actaaattca
    13321 aattgagagg atgaattaaa atgaataaaa tatttatata tgcaggagtg cgaaatcata
    13381 actctaagac tttagagtat actaagagac tttcaagtat catttctagt agaaataatg
    13441 ttgatatatc tttcaggaca cctttcaatt cagagctaga aatatctaat tctgattcag
    13501 aagagttgtt taagaaagga attgataggc aaagtaatgc tgatgatgga ggtgttataa
    13561 aaaaagagtt attagagtct gatattataa ttatctcttc tcctgtatat ttacaaaacg
    13621 tatctgtgga cacaaaaaac tttattgaaa ggattggggg gtggagccat ctttttcgat
    13681 tagctggaaa gtttgttgta acattagatg ttgctgagag taacggctct gataatgtgt
    13741 cagaatatct tagagatata ttttcatata tgggaggaca gatattacac caagtttcaa
    13801 ttaccaattc actcaaagat attgcagagg ctcagttgat ggaggcaact tataaaattg
    13861 aagatgtact tgaagggaaa attaagtaca aaacaacgga ttatcaagaa agagcttacc
    13921 agacattaaa attaatttta gaaaattatg attccgaaca ttttgagaag atgtattggg
    13981 agaaaaaacg cctttttgaa gctaatagtt tagaggaatg gtattatgtt gaaaatatta
    14041 aataactctg tcatatattt atgtttgatt ccgttattgt tcctattatt gataattttt
    14101 ccaaatgatt cattaatcta ttattttcga ttgattttaa tttcgttaat atcaattaca
    14161 ttacatgaac taggtcattt tttagtggga agatgtttat cttataaact agagatgctt
    14221 gctactccct ttttcttcta tttcagaaaa aaaatatatt tcaaatttcc agtgttatta
    14281 gcattcggtt attgtcaaat gagtaataga aacattacta atgaaaaaaa tagtgatagg
    14341 aatttggtgt tctacttctt tgggggaggt ggagctaacc taattgtcgc aatattagca
    14401 cttttgggat ttgtgccgta cgcatcagaa ttttttattt tgaatataat tctttttcta
    14461 gttacggtat gtttaccaat tgatggaaca gatggcaatg ctattagaga gatagttttg
    14521 tattcaaaag attcaaaaac atatcagaga ttctttgcga acagtctcta taataatcct
    14581 tatataacaa tcgacgattt tgcaaaatta acctctaaag aaaaatcttt tttttcaaaa
    14641 tttgaaaaat gtttgataaa cctttacttt gaagtgaaag gtgaagggtc agcatttaca
    14701 attgctaatc atgaagtttt tgattcaaat attcaggaaa atattatcca tgagtactat
    14761 aaattactac ataaatcttc tgattggatt attccacaga acttatcttt agaagaagtt
    14821 gtttttacct tgtcaaacta tatttactcg aaaaataata aatatttaga aaagattaag
    14881 tatctaaaga aattagtaga ttttagacaa gaagaaatta tcgactttat tttgaacaag
    14941 gaggaagtat tgtgaaaatt ccaatgatat atcaaatgga aaattcagaa tgtggattag
    15001 catgctgtgc catgatattg aactatttta aatatgagat ttctttaaat gaactacgtg
    15061 aaatctaccc atcatccaga tctggatatt ctctcctatc tataagtaaa gttttaggag
    15121 attttaatat aagttctcat gcttttaaag cttcggtaag agatttaaaa ccgctcagtt
    15181 tcccactcat ttgcttctgg gagagttctc attttattat tcttgaaaaa attagtaaaa
    15241 acaagtttta tattttagat cctgcaaaag gcaggcagag aatgtcaata agtgaatttg
    15301 aaaggcatta ttcaaatatc attttaacat ttaaaaagtt agatagcttt atgtctcgta
    15361 aagataataa gaagtcgcct gttttaaagt atttttttaa gtataggaat aagctaggga
    15421 ttttattttt tgtaacagca ttattgtatg taatacaatc attagtacct atagctaata
    15481 gatacataat tgacacgaat ttcaaggacg attcgtattc gtctagaatg ttatttacta
    15541 tattatttat atttactgtt tcattctcac taatgtattt attaagacag atatatgttg
    15601 catccttaaa atatataatg gataaagaga ttagctatga ttttatgaaa catttgatat
    15661 atttacctta cagtttttat gaaaaacgta ctttagggga tatacttttt agagctaact
    15721 ctattgttta tataagagaa atactatcaa ataattttat agcagctata cttgatttgt
    15781 taatgattgt ggtttatgct gtggttttat ttagcttttc taagtacatg gtaatctttt
    15841 taatatcact aagtctagct ctatctattg taatgtatcc aatcataaaa atctcaaaaa
    15901 atttaattga taaaaatata aaagaaaagg ttaatgttca aaatattact tccgaagtaa
    15961 tttctaaaaa tagtgatatt aagctaactg gagaagagga attttggatt aacaaatggg
    16021 ataattttaa tacaaaacag ctcatcatag gtcgaaaact tgatatacat ttatcaattg
    16081 ttagtagtat aacgaatgtt ttacaaatta ttctccctgt tttgaccctt attgtaggtg
    16141 taaatataaa aacattcgaa caattgacgt taggacaaat tgtagcaata agtacagtct
    16201 caccatactt tatttctcct ataatttctt taagtgataa ctatatacaa ttaatgttat
    16261 taaagggata ttttttaaga atagaggatg tgtttaatac taaatccgaa ttaattccag
    16321 aaagagtcag tcaagatata aaatttgata aaaaaataaa attaaaagat atttggtata
    16381 aatatggatt atttgatgat tatgttttga aaggaataaa tgttactatt aaaaaaggag
    16441 aaactgttgc tattgttgga gaatcaggtt caggtaagag tacattagct aaaattttat
    16501 taggtttatt agaacctaat attggttcaa tagaagttga tggagtagaa aaagaagaaa
    16561 ttggtcaaac attgtataga aagatttttg gagcagtgtt acaaaattca accctaagtt
    16621 atggtacctt aagagagaat ttgacatttg gacactttgt ttcagatgaa gaattaatga
    16681 caaatctaaa ttcaattggt cttagcaatg tagttaaatc tttacctctt ggattagaga
    16741 caatcatcgc tgaagaaggt aataactttt ctggagggca gcagcaaatg atacttttag
    16801 ctcgttgtct tttgtcgaaa ccttcggtag ttgttttgga cgaagcaaca agtagtttag
    16861 ataatttatc tcaacaaatt acaacttctt acttaagtga aatcggtacc actaagattt
    16921 taattgccca tcgactagat actatcaagt ctgcagataa gatcttagta atgcataatg
    16981 gtgaaattgt agagattggg acccatagag aacttcttga actaggaggc atttataagc
    17041 aattgtattc aaataattag tttttgatta aaagggtaaa tttatgaaga ttatgaaaaa
    17101 aaaatattgg actttagcga tattattctt ttgtttgttc aataattctg ttactgctca
    17161 agaaatacct aaaaatcttg atggcaatat aactcacact cagactagcg aaagtttttc
    17221 tgaatctgat gaaaaacagg ttgactattc taataaaaat caagaagaag tagaccaaaa
    17281 taaatttcgt attcaaatcg ataagacaga attatttgta acaacagata aacatttaga
    17341 aaaaaactgt tgtaaattgg aacttgaacc acaaataaat aacgatattg ttaactctga
    17401 aagtaataat ttactaggcg aagataattt agataataaa attaaggaaa atgtttctca
    17461 tctagataat agaggaggaa atatagagca tgacaaagat aacttagaat cgtcgattgt
    17521 aagaaaatat gaatgggata tagataaagt tactggtgga ggcgaaagtt ataaattata
    17581 ttctaaaagt aattctaaag tttcaattgc tattttagat tcaggagtcg atttacaaaa
    17641 tactggatta ctgaaaaatc tttcaaatca ctcaaaaaac tatgtcccca ataaaggata
    17701 tttaggaaaa gaggagggag aggaaggaat aatatcagat attcaagata gattaggtca
    17761 tggtacggct gttgtagctc aaattgtagg ggatgacaat attaatggag taaatcctca
    17821 cgttaatatt aacgtctata gaatatttgg taagtcgtca gctagtccag attggattgt
    17881 aaaagcaatt tttgatgctg tagatgatgg caatgatatt atcaatctta gtactggaca
    17941 atatttaatg attgatggag aatatgagga cggaacaaat gattttgaaa catttttgaa
    18001 gtataaaaag gctattgatt acgcgaatca aaaaggagta attatagtag ctgcattagg
    18061 gaatgactcc ctaaatgtat caaatcagtc agatttattg aaacttatta gttcacgcaa
    18121 aaaagtaaga aaaccaggat tagtagttga tgttccaagt tatttctcat ctacaatttc
    18181 ggtcggaggc atagatcgct taggtaattt atcagatttt agcaataaag gggattctga
    18241 tgcaatatat gcgcctgcag gctcaacatt atctctttca gaattaggac ttaataactt
    18301 tattaatgca gaaaaatata aagaagattg gattttttcg gcaacactag gaggatatac
    18361 gtatctttat ggaaactcat ttgctgctcc taaagtttct ggtgcgattg caatgattat
    18421 tgataaatac aaattaaaag atcagcccta taattatatg tttgtaaaaa aaattctgga
    18481 agaaacatta ccagtaaaaa atggtataaa agtgttaaat ataccaaacg tattgagata
    18541 tgatttgaat atgttacaat tagaatataa aaatgaacaa agttgggata gtttcataga
    18601 taatgttaat ttaattgagt tggaagagag aattcaaact actattggaa ttaaacaaat
    18661 aaacacacac aatattatta ctattgcccg agaagggtac tctcaaaatt atttacctaa
    18721 cacttcagaa aatacatata attcattaca agtcagttta gttggagtat tactactttt
    18781 tataagtatg gtaaatattt tatgggctaa aaaaagtaaa tgaaaataaa atttggagcc
    18841 ctctgaaaaa gtaagtccta cagttcaact aaaatgagtc aaaagatgaa tcaccttgat
    18901 gtaggggagt ttgtcttatt gctgcctgaa cacctccgtt cagaggaaga acattataaa
    18961 tctgtttttg aagacgactt aaccagtcgc atgtctagtc aagatgaacg acagcaaatg
    19021 actgctacgg taggttattt agaatcaggt caggatcgtt ttgtgtataa tacgacccct
    19081 atttcttacc agcagttttt gaaagatcca atcatcattg ttataacacc ccaatcaact
    19141 ggtccacagt ccattttgtt ttggatagac gcagtacaga actacgttct ctttaatcaa
    19201 ttgtctgatg cccaggagct tatccagaga caaggcattg aaaattgggt ctcagaaatg
    19261 caaacaggtt accacaacta catcacatta ttggataata tccagaggga acgttgggta
    19321 atgctagcag gagctgtgct tgggattgca acttcaatct tgttgtttaa cactatgaat
    19381 aggctctact ttgaagaatt tagacgtgcc atttttatca aacgcattgc aggtctcagg
    19441 ttcttagaaa tccatcgcac ttatctcttt gctcaactgg gtgtgttttt actgggattt
    19501 gttgcgagtg tatttcttca ggtagagata ggagttgctt tcttagtctt gttactcttt
    19561 actggtctat ctcttttaca gttacatgtc caaatgcaga aagaaaacaa gatgtccatg
    19621 cttgttttga agggaggtta atatgattga acttaaacag gtgagtaaat cttttggaga
    19681 acgagagtta ttttcgaatc tttcaatgac atttgaggct ggaaaagtct atgccttaat
    19741 tggttcaagt ggtagcggaa aaacaacctt gatgaacatg attgggaaat tagaacctta
    19801 tgatgggacg attttttacc gaggtaaaga cttggccaat tataaatcaa gtgatttttt
    19861 ccgtcacgaa ttgggctacc tcttccagaa ctttggctta attgaaaacc aaagtattga
    19921 agaaaacctt aagctaggtc tcattggtca aaagttgagt cggtcggaac agcggttgag
    19981 gcagaagcag gctttagaac aggtcggcct ggtttatctt gacctagata agcgcatctt
    20041 tgagttatcg ggcggagaat cgcaacgggt tgccttggca aaaattatct taaagaatcc
    20101 accctttatt ctggcagatg agccaacagc ttcaatagac ccagcaacct ctcagttgat
    20161 tatgtagatt ttgctatctc ttcgagatga taataggcta atcattatcg caacacataa
    20221 tccggcaatt tgggagatgg ctgatgaagt gttcacgatg gatcatctga aataaaaatc
    20281 cttgttttta attgcacgat gagttactga aatattatca tgaatcaaga attggagtta
    20341 atttagaatt gtactttatt aatattgagg taactttttc ttgataaagg aagaaataat
    20401 ggagaggaag ttagaatgaa aaaattcgac aattatatta ttgagaagcc ttgcgattct
    20461 aattcagata aactgcaaaa aatcttaata attgaaagtt tggtagatga tattttgcaa
    20521 ttttctctca gaatcaataa tagtgtagga gagattttcc tcctacaacc gttttaaaag
    20581 aaaactatct ttattccatg ttattttgag gaagatattg tgaaagtcaa agatgatgat
    20641 aaagttgagt ggaatttgtt agaatttcaa aaatttagag catttttggc ttagtaatct
    20701 gtgttgaagg ctcaaaacct atggtaaaaa agtagctttg aaaacgtatt gcctccaaag
    20761 atttagttaa ataatgattt aacacaaaaa gaaattattg aagttctgga aagatgttgt
    20821 ttcagtattg agaaaaggtg ggaaaaactt gcgattttca cagagaaagg aagaaaaagt
    20881 atagaaatat agtcaattga aacaagaaca ggataaaaga accttttgtg ccatattttt
    20941 ctcctttcgc tttacaattg gattgaacac ctttattgta tcgcgtttgg agtttttttg
    21001 gtataacctt cgacgcgcac ccgcatagcg ggtgtttttt tgtctcgcac ctaacggagc
    21061 gagacaaact aatagtcact taatcaaaaa acgcaccata tcaaaaacta aaaagtttga
    21121 tatcatgcgt catgtcttaa actaattgac tatactttct attcaaatga gcttttaacc
    21181 aattgattga gccaatccac tcttaaaacc aaagagcaat ttctcgctta gctgactctt
    21241 ctgaatctga accatgtaca acattttgga taatatcatt ttctccagca gcttttgcaa
    21301 aatcacctcg aatagtgcct ggtaaagctt cttctggacg agttgcaccc atcatggtcc
    21361 gccaagtttc gattactttg ggaccagaaa tgacacccac aagaactgga cctgaagtca
    21421 tgaattcacg aatcggtggg taaaaactct gaccaaccaa gtcctgatag tgctggtcaa
    21481 tcaactcttc tgaaacctgt gaacgaaact ccaatttttc gattgtaaat ccacgttgtt
    21541 cgatgcgctt taacacttca cccactagcc ctctttttac accatctggt ttgatgataa
    21601 agaatgtttg ttccataccc gtctcctttg tcagcttctt tcttttattt taccacattt
    21661 cgtggaaaaa tggagaaagt tttcagaaga gagaatgaga gaaccctcgg gttctctcat
    21721 tctctcttat tctactgttt cttccacagt ttcaacggca gtatccacaa ctacttctgt
    21781 tgtttcttca tttccttctt cctctactgg aggattaagg tattcttctt cgttgacagc
    21841 atgtggttca aggttacggt aacgggccat accagtacca gctgggatga tcttaccgat
    21901 gataacattt tctttaagtc caaggagatg gtctttctta ccacggatag ctgcgtcagt
    21961 aaggacacga gttgtttcct ggaaggaagc cgctgacaag aaactgtttg tttcaagtga
    22021 ggctttggta attcccataa ggactggacg acctgtcgct ggaactccac ctgcgataag
    22081 gacatctttg ttggcatctg taaagtcatt gatatccatg agggtaccca tgagaagatc
    22141 tgtatcacct ggatccatga cacggacttt acggatcatt tgacgaacca ttacctcgat
    22201 gtgtttgtca ccgatttcta ccccttggct acggtaaact ttttgtactt caccgagaag
    22261 gtacgtttca actgacaaga catcacgaac tgcaaggaga cgttttggtt ggatagaacc
    22321 ttctgtcaga gcagcaccac gcgctacttg gcccccaact tcgacacgca tacgagctgt
    22381 aaatggaacg acatattcac cttcgccagt ttcaccctta acaaagactt tcttggtacg
    22441 agttgatgca tcttcttcga tagcagtaac ttgtccttta acctctgtaa taaccgcttc
    22501 ccctttagga ttgcgggctt caaagatttc ttggacacga ggaagaccct gagtgatatc
    22561 ggtatttgag gcaaccccac ctgtgtggaa ggtacgcatt gtaagctgtg taccaggttc
    22621 cccgatagat tgggcagcga ttgtaccaac tgcttcacca acttcaaccg catcaccagt
    22681 cgccaagttg ataccgtaac agtgacggca gacaccgtga cgagtgttac atgtaaatac
    22741 agaacggata gtcacttctt ccacaccagc attgacaatt tcacgcgcct tgtcttctgt
    22801 aatcaattca tttggaccaa taatcactgc accagtttct ggatgtttaa cagttttctt
    22861 agtgtaacga ccgttgagac gctcttcgag agactcgatc atctcttttc cttctgcgat
    22921 agaacggatc aagagaccac ggtcagttcc acagtcgtcc tcacggatga taacgtcttg
    22981 ggcaacgtcg a
//
