LOCUS       NZ_CP035253            20876 bp    DNA     circular CON 19-DEC-2024
DEFINITION  Streptococcus pneumoniae strain TVO_1901933 chromosome.
ACCESSION   NZ_CP035253
VERSION     NZ_CP035253.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 2130843)
  AUTHORS   Rosconi,F., Cotton,S.L., Kempchinsky,A., Surujon,D., Johnston,C.D.
            and van Opijnen,T.
  TITLE     Streptococcus pneumoniae DNA-modification patterns determined at the
            pan-genome level
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2130843)
  AUTHORS   Rosconi,F., Cotton,S.L., Kempchinsky,A., Surujon,D., Johnston,C.D.
            and van Opijnen,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JAN-2019) Biology, Boston College, 140 Commonwealth
            Avenue, Boston, MA 02467, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 05-NOV-2018
            Assembly Method                   :: HGAP v. 4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 299x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022070145.1-RS_2024_12_19
            Annotation Date                   :: 12/19/2024 10:37:21
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,215
            CDSs (total)                      :: 2,141
            Genes (coding)                    :: 1,992
            CDSs (with protein)               :: 1,992
            Genes (RNA)                       :: 74
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 149
            CDSs (without protein)            :: 149
            Pseudo Genes (ambiguous residues) :: 0 of 149
            Pseudo Genes (frameshifted)       :: 69 of 149
            Pseudo Genes (incomplete)         :: 70 of 149
            Pseudo Genes (internal stop)      :: 56 of 149
            Pseudo Genes (multiple problems)  :: 39 of 149
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:26:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1095746
            Orig. end                         :: 1116622
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP035253.1.
            Genome not circularized.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20876
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="4"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..20876
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20876
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10876](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10876)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    91..104
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 21.2"
                     /tool="antismash"
     gene            complement(738..1253)
                     /gene="lacB"
                     /locus_tag="EQH27_RS05465"
                     /old_locus_tag="EQH27_05820"
     CDS             complement(738..1253)
                     /codon_start=1
                     /gene="lacB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994294.1"
                     /locus_tag="EQH27_RS05465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_05820"
                     /product="galactose-6-phosphate isomerase subunit LacB"
                     /protein_id="WP_001216910.1"
                     /transl_table=11
                     /translation="MRIAIGCDHIVTDEKMAVSEFLKSKGYEVIDFGTYDHTRTHYPIF
                     GKKVGEAVTSGQADLGVCICGTGVGINNAVNKVPGVRSALVRDMTTALYAKEQLNANVI
                     GFGGKITGELLMCDIIEAFIHAEYKPSEENKKLIAKIEHLESHNAQQTDANFFTEFLEK
                     WDRGEYHD"
     gene            complement(1284..1709)
                     /gene="lacA"
                     /locus_tag="EQH27_RS05470"
                     /old_locus_tag="EQH27_05825"
     CDS             complement(1284..1709)
                     /EC_number="5.3.1.26"
                     /GO_function="GO:0050044 - galactose-6-phosphate isomerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /gene="lacA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398701.1"
                     /locus_tag="EQH27_RS05470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_05825"
                     /product="galactose-6-phosphate isomerase subunit LacA"
                     /protein_id="WP_000029272.1"
                     /transl_table=11
                     /translation="MSIVIGADAAGLRLKEVVKDFLEKENFHLVDVTAEGQDFVDVTLA
                     VAAEVNKEEQNLGIVIDAYGAGPFMVATKIKGMVAAEVSDERSAYMTRGHNNSRMITMG
                     AQLVGDELAKNIAKGFVNGKYDGGRHQIRVDMLNKMG"
     gene            complement(1866..>2363)
                     /locus_tag="EQH27_RS05475"
                     /old_locus_tag="EQH27_05830"
                     /pseudo=""
     CDS             complement(1866..>2363)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000234238.1"
                     /locus_tag="EQH27_RS05475"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_05830"
                     /product="aldose 1-epimerase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="NKETSKVRPYFIGGHPGFNCPLLDDEVYEDYYLEFEKEETCSVPR
                     PFPETGMLDFQDRSPWLEGQKEIDLSYDLFSKDAVTLDELQSRTIALRSLKHDRGLKVH
                     FAEFPNLIIWSTLNKGPFITFEPWSGLSTFLEEGDHLEDKKNVCLLEANQVEELGFEIE
                     VL"
     gene            complement(2379..3181)
                     /locus_tag="EQH27_RS10995"
                     /old_locus_tag="EQH27_05835"
                     /pseudo=""
     CDS             complement(2379..3181)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /locus_tag="EQH27_RS10995"
                     /note="programmed frameshift; internal stop; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="EQH27_05835"
                     /product="IS5 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNDEASKQLTDARFKRLVGVQRTTFKEMLAVLKTAYQLKHAKGGR
                     KPKLSLEDLLMATLQYVREYRTYEEIAADFGIHESNLLRRS"
     gene            complement(3201..3491)
                     /locus_tag="EQH27_RS05490"
                     /old_locus_tag="EQH27_05840"
     CDS             complement(3201..3491)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000590558.1"
                     /locus_tag="EQH27_RS05490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_05840"
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="WP_000590558.1"
                     /transl_table=11
                     /translation="MIKILAACGAGVNSSHQIKSALEEELSNRGYDVHCDAVMVKDVNE
                     DLMKGYDIFTPIAATDLGFEPGIPVIEAGPILFCIPAMSVPVFDNIRLPAK"
     misc_feature    3511..3524
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.08"
                     /tool="antismash"
     gene            complement(3529..4005)
                     /locus_tag="EQH27_RS05495"
                     /old_locus_tag="EQH27_05845"
     CDS             complement(3529..4005)
                     /GO_component="GO:1902495 - transmembrane transporter
                     complex [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000242196.1"
                     /locus_tag="EQH27_RS05495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_05845"
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="WP_000242186.1"
                     /transl_table=11
                     /translation="MVLDYFFDKNLVFCLEADNQEQLFDQVASLLEEREIVTPTYREAL
                     ITREKSFPTGLDMEFLGKDLPNVAIPHTDIVHNLAEKVVVVRLEKPVTFHNMIAPDKEV
                     EVSLLFFIINNSSSSQTNILAQLMNFFTGNGHLEDLSKISEPEKLYAYIDEAIA"
     gene            4185..4382
                     /locus_tag="EQH27_RS05500"
                     /old_locus_tag="EQH27_05850"
     CDS             4185..4382
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EQH27_RS05500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EQH27_05850"
                     /product="hypothetical protein"
                     /protein_id="WP_000693362.1"
                     /transl_table=11
                     /translation="MKIKEQTRKLAAGYSKHSFEVVDETDEVSSKHDFEVVDETDEVSN
                     HTYGKATLTWFEEIFEEYKN"
     gene            complement(4463..6286)
                     /gene="lepA"
                     /locus_tag="EQH27_RS05505"
                     /old_locus_tag="EQH27_05855"
     CDS             complement(4463..6286)
                     /EC_number="3.6.5.n1"
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /gene="lepA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190: GTP-binding protein LepA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001047203.1"
                     /locus_tag="EQH27_RS05505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_05855"
                     /product="translation elongation factor 4"
                     /protein_id="WP_001047212.1"
                     /transl_table=11
                     /translation="MNLEELKKRQEKIRNFSIIAHIDHGKSTLADRILEKTETVSSREM
                     QAQLLDSMELERERGITIKLNAIELNYTAKDGETYIFHLIDTPGHVDFTYEVSRSLAAC
                     EGAILVVDAAQGIEAQTLANVYLALDNDLEIMPIINKIDLPAADPERVRTEIEDVIGLD
                     ASEAVLASAKAGIGIEEILEQIVEKVPAPTGDVTAPLKALIFDSVYDAYRGVILQVRVM
                     DGVVKPGDKIQLMSNSKTFDVAEVGIFTPKAVGRDFLATGDVGYIAASIKTVQDTRVGD
                     TVTLATNPAAEPLHGYKQMNPMVFAGLYPIESNKYNDLREALEKLQLNDASLQFEPETS
                     QALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVIYKVNLTDGESMDVSNPSEF
                     PDPTKIATIEEPYVKAQIMVPQEFVGAVMELAQRKRGDFVTMDYIDDNRVNVIYQIPLA
                     EIVFDFFDKLKSSTRGYASFDYELSEYRPSKLVKMDILLNGDKVDALSFIVHKDFAYER
                     GKLIVDKLKKIIPRQQFEVPIQAAIGHKIVARTDIKALRKNVLAKCYGGDVSRKRKLLE
                     KQKAGKKRMKSIGSVEVPQEAFLSVLSMDEE"
     gene            complement(6365..7093)
                     /locus_tag="EQH27_RS05510"
                     /old_locus_tag="EQH27_05860"
     CDS             complement(6365..7093)
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000133310.1"
                     /locus_tag="EQH27_RS05510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_05860"
                     /product="metallophosphoesterase family protein"
                     /protein_id="WP_000133326.1"
                     /transl_table=11
                     /translation="MTDYYVIGDVHGKAGMLEDLLKTWDGKTQLLFLGDLIDRGEDSHR
                     VLEMVKDLVDNQGAICLSGNHEYMFLTWLDDPEESYDHYRRNGGDTTINSILGRPLDAP
                     VDGVEDAKRVAAEASDLVEFIRQMPFVVETDKYIFVHAGIDLTLDDWHETTDYKKVWLR
                     KPFHGAENHTGKTIVFGHTPVYGLLQQERGTSELWTTEDGKIGMDGGAVYGGVLHGIVF
                     TDQGMTEHHFIENDGFVAED"
     gene            complement(7095..8762)
                     /gene="recN"
                     /locus_tag="EQH27_RS05515"
                     /old_locus_tag="EQH27_05865"
     CDS             complement(7095..8762)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="recN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399602.1"
                     /locus_tag="EQH27_RS05515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_05865"
                     /product="DNA repair protein RecN"
                     /protein_id="WP_000923577.1"
                     /transl_table=11
                     /translation="MLLEISIKNFAIIEAISLNFEKGMTVLTGETGAGKSIIIDAMNMM
                     LGARATTDVIRHGAPKAEIEGLFSVENSRLLQEIFDEQGLELGDEIIIRREILQNGRSI
                     SRVNGQMVNLSVLRAIGQHLVDIHGQHDHEELMRPQLHIQMLDEFGDAAFWDLKETYQT
                     SFDAYRKMRKQVLEVKKNQQEHKARIEMLEFQMAEIEAANLQAGEDLALNQERDKLLNH
                     KNIADTLTNAYSMLDNEDFSSLANVRSAMNDMESVEEYDSEYREISSSLSETYYVLEDI
                     SKRLEAIIEDLDFDGNRLMQVENRLDLLHTITRKYGGTVDDVLLYFAKITEEYNLLTGN
                     NLSSEDMEAELKKLEVNLVNLAGQLASARHNLAQQLEAEIKQELQDLYMEKAQFQVRFS
                     KGKFSREGNEMVEFYISTNPGEDFKPLVKVASGGELSRLMLAIKSAFSRKEGKTSIVFD
                     EVDTGVSGRVAQAIAQKIHKIGQHGQVLAISHLPQVIAIADYQFFIEKISNDHSTVSTV
                     RLLTVEERVEEVAKMLAGDDVTEAALTQARELLRNREK"
     gene            complement(8769..9200)
                     /locus_tag="EQH27_RS05520"
                     /old_locus_tag="EQH27_05870"
     CDS             complement(8769..9200)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001034407.1"
                     /locus_tag="EQH27_RS05520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_05870"
                     /product="arginine repressor"
                     /protein_id="WP_001034412.1"
                     /transl_table=11
                     /translation="MNKKERLEKIRRLVTDYQIGTQEEIVEHLKEAGITATQATVSRDI
                     KELGIVKIPLRDNTYVYELPKSIVKSLQLAEDNIESAELMDKMINLQVIPGNTAFVKAQ
                     LIDTFADKIFSCLTDDSSILVIARSGSLAEEIFEQVKNW"
     gene            complement(9193..10008)
                     /locus_tag="EQH27_RS05525"
                     /old_locus_tag="EQH27_05875"
     CDS             complement(9193..10008)
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001041085.1"
                     /locus_tag="EQH27_RS05525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_05875"
                     /product="TlyA family RNA methyltransferase"
                     /protein_id="WP_001041079.1"
                     /transl_table=11
                     /translation="MAKERVDVLAYKQGLFETREQAKRGVMAGLVVAVLNGERFDKPGE
                     KIPDDTELKLKGEKLKYVSRGGLKLEKALQVFDLSVDGATTIDIGASTGGFTDVMLQNS
                     AKLVFAVDVGTNQLAWKLRQDPRVVSMEQFNFRYAEKTDFEQEPSFASIDVSFISLSLI
                     LPALHRVLADQGQVVALVKPQFEAGREQIGKNGIIRDAKVHQNVLESVTAMAVEVGFSV
                     LGLDFSPIQGGHGNIEFLAYLKKEKSASNQILAEIKEAVERAHSQFKNE"
     gene            complement(10001..10876)
                     /locus_tag="EQH27_RS05530"
                     /old_locus_tag="EQH27_05880"
     CDS             complement(10001..10876)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000743807.1"
                     /locus_tag="EQH27_RS05530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_05880"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_000743809.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 7e-56, bitscore:
                     186.4, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKQEKLALVESALEDFYGDQQFASSLRESVLYSIHAGGKRIRPF
                     LLLEVLEALQVAIKPAHAQVATALEMIHTGSLIHDDLPAMDDDDYRRGRLTNHKKFGEA
                     MAILAGDALFLDPYALIAQADLPSQIKVDLIANLSLASGSLGMVAGQVLDMEGEHQHLS
                     LEELQTIHANKTGKLLAYPFQAAAIIAELSPEMQVKLKTVGELIGLAFQVRDDVLDVTA
                     SFEEIGKTPQKDLQAEKSTYPALLGLEESIAFCNQTLDQANEKLEEIAQQVPFETESIV
                     SVVESLRING"
     gene            complement(10873..11085)
                     /locus_tag="EQH27_RS05535"
                     /old_locus_tag="EQH27_05885"
     CDS             complement(10873..11085)
                     /EC_number="3.1.11.6"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809086.1"
                     /locus_tag="EQH27_RS05535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_05885"
                     /product="exodeoxyribonuclease VII small subunit"
                     /protein_id="WP_000043230.1"
                     /transl_table=11
                     /translation="MSKQKKFEENLAELETIVQSLENGEIALEDAITAFQKGMVLSKEL
                     QATLDKAEKTLVKVMQEDGTESDFE"
     gene            complement(11063..12403)
                     /gene="xseA"
                     /locus_tag="EQH27_RS05540"
                     /old_locus_tag="EQH27_05890"
     CDS             complement(11063..12403)
                     /EC_number="3.1.11.6"
                     /GO_component="GO:0009318 - exodeoxyribonuclease VII
                     complex [Evidence IEA]"
                     /GO_function="GO:0008855 - exodeoxyribonuclease VII
                     activity [Evidence IEA]"
                     /GO_process="GO:0006308 - DNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="xseA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012000165.1"
                     /locus_tag="EQH27_RS05540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_05890"
                     /product="exodeoxyribonuclease VII large subunit"
                     /protein_id="WP_000417446.1"
                     /transl_table=11
                     /translation="MEKYLSVTTLTKYLKMKFDKDPYLERVYLTGQVSNFRKRPTHQYF
                     SLKDDHAVIQATIWSGIYQKLGFDLEEGMKINVIGRVQVYELSGSYSIIIEKAEPDGVG
                     ALAIQFEQLKKKLTEEGLFQERFKQALPQFSKRIGVVTSRSGAVIRDIITTVSRRFPGV
                     DILLYPTKVQGEGAAEEIARNIARANQRDDLDLLIIGRGGGSIEDLWAFNEEIVVRAIF
                     ESRLPVISSVGHETDVTLADFVADRRAATPTAAAELATPVTKLDVLAHLQNQEKRMATA
                     VRNVLSKKQEALKKCSQSVIFRQPERLYDGYLQRLDQLQLRLKQSLRTRISDNKQLVQA
                     RTHQLVQLSPVTKIQRYQDRLGQLDKLLGSQMALVYDAKVAEAKRLSEALLMLDTSRIV
                     ARGYAIVKKEESVVDSVESLKKKDQVTLLMRDGQVELEVKDVKTKEI"
     gene            complement(12531..13169)
                     /gene="udk"
                     /locus_tag="EQH27_RS05545"
                     /old_locus_tag="EQH27_05895"
     CDS             complement(12531..13169)
                     /EC_number="2.7.1.48"
                     /GO_function="GO:0004849 - uridine kinase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="udk"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181378.1"
                     /locus_tag="EQH27_RS05545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_05895"
                     /product="uridine kinase"
                     /protein_id="WP_001181378.1"
                     /transl_table=11
                     /translation="MQNRPIIIGVTGGSGGGKTSVSRAILSHFPDEKISMIEHDSYYKD
                     QSHLTFEERVKTNYDHPFAFDTDLMIEQIKELLAGRPVDIPTYDYTEHTRSSKTYRQEP
                     QDVFIVEGILVLEDKRLRDLMDIKIFVDTDDDVRIIRRIKRDMEERGRSLDSVINQYLG
                     VVKPMYHQFIESTKRYADIVIPEGVSNTVAIDLLTTKIAKILEEARNSK"
     misc_feature    13209..13223
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.39"
                     /tool="antismash"
     gene            complement(13277..13579)
                     /locus_tag="EQH27_RS05550"
                     /old_locus_tag="EQH27_05905"
     CDS             complement(13277..13579)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000985087.1"
                     /locus_tag="EQH27_RS05550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_05905"
                     /product="bacteriocin immunity protein"
                     /protein_id="WP_000985093.1"
                     /transl_table=11
                     /translation="MMRNEFRERVEQLLQQKEINENSELSHLFRLAIQNLDRNEKYQTV
                     MANLSQGLSLYLMTHHYQAPKSVIDFGLWIAKAPSQERGRLAFLQMLAQTLQGFR"
     gene            complement(13840..14718)
                     /gene="truB"
                     /locus_tag="EQH27_RS05555"
                     /old_locus_tag="EQH27_05910"
     CDS             complement(13840..14718)
                     /EC_number="5.4.99.25"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0009982 - pseudouridine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0001522 - pseudouridine synthesis [Evidence
                     IEA]"
                     /GO_process="GO:0009451 - RNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="truB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006145474.1"
                     /locus_tag="EQH27_RS05555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_05910"
                     /product="tRNA pseudouridine(55) synthase TruB"
                     /protein_id="WP_001013253.1"
                     /transl_table=11
                     /translation="MNGIINLKKEAGMTSHDAVFKLRKILGTKKIGHGGTLDPDVVGVL
                     PIAVGKATRMVEFMQDEGKIYEGEITLGYSTTTEDASGEVVAETPVLSPLDEKLVDEAI
                     ASLTGLITQIPPMYSAVKVNGRKLYEYARAGQEVERPERQVTIYQFERTSPISYDGQLA
                     RFTFRVKCSKGTYIRTLSVDLGEKLGYAAHMSHLTRTSAAGLQLEDALTLEEIVEKVEA
                     GQLDFLRPLEIGTGDLVKVFLTPEEATEVRFGRFIELDQTDKELAAFEDDKLLAILEKR
                     GNLYKPRKVFS"
     gene            complement(14727..16001)
                     /locus_tag="EQH27_RS05560"
                     /old_locus_tag="EQH27_05915"
     CDS             complement(14727..16001)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001002592.1"
                     /locus_tag="EQH27_RS05560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_05915"
                     /product="DUF2130 domain-containing protein"
                     /protein_id="WP_001002635.1"
                     /transl_table=11
                     /translation="MNEIKCPNCGEVFTVNESQYAELLSQVRTAEFDKELHDRMRQELA
                     LAEQKAMNEQQTKLAQKDQEIAQLQSQIQNFDTEKELAKKEVEQTSHQALLAKDKEVQA
                     LENQLATLRLEHENQLQKTLSDLEKERNQVKNQLLLQEKENELSLASVKQNYEAQLKAA
                     SEQVEFYKNFKAQQSTKAIGESLEQYAESEFNKVRSFAFPNAYFEKDNKVSSRGSKGDF
                     IFRECDENGVEIISIMFEMKNEADGTEKKHKNADFYKELDKDRREKNCEYAVLVTMLEA
                     DNDYFNTGIVDVSHEYEKMYVVRPQFFIQLIGLLRNAALNSLKYKQELALVREQNIDIT
                     HFEEDLDAFKLAFAKNYNSASTNFGKAIDEIDKAIKRMEEVKKFLTTSENQLRLANNKL
                     EDVSVKKLTRKNPTMKAKFEALKGE"
     gene            complement(16097..17356)
                     /locus_tag="EQH27_RS05565"
                     /old_locus_tag="EQH27_05920"
                     /pseudo=""
     CDS             complement(16097..17356)
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0019346 - transsulfuration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018365067.1"
                     /locus_tag="EQH27_RS05565"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_05920"
                     /product="O-acetylhomoserine
                     aminocarboxypropyltransferase/cysteine synthase family
                     protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTRDFKFETLQLHAGQVVTPATESRAVPIYQTTSFVFDDT"
     gene            complement(17504..18301)
                     /locus_tag="EQH27_RS05570"
                     /old_locus_tag="EQH27_05925"
     CDS             complement(17504..18301)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0015499 - formate transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0015724 - formate transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000254803.1"
                     /locus_tag="EQH27_RS05570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_05925"
                     /product="formate/nitrite transporter family protein"
                     /protein_id="WP_000625730.1"
                     /transl_table=11
                     /translation="MISSEFISKIEFACNKKESLYSQSKFKYAIRSIFAGAFLTFSTAA
                     GAVGADLINKIAPGSGRFLFPFVFAWGLAYIVFLNAELVTSNMMFLTAGSFLKKISWRK
                     TAEILLYCTLFNLIGSLIAGWGFAHSAAYANLTHDSFISGVVEMKLGRSNELVLLEAIL
                     ANIFVNIAILSFILVKDGGAKLWLVLSAIYMFVFLTNEHIAANFASFAIVKFSVAADSI
                     ANFGVGNMLRHWGVTFIGNFIGGGLLMGLPYAFLNKNEDTYVD"
     misc_feature    complement(18454..18468)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.52"
                     /tool="antismash"
     gene            complement(18545..19288)
                     /gene="srtA"
                     /locus_tag="EQH27_RS05575"
                     /old_locus_tag="EQH27_05930"
     CDS             complement(18545..19288)
                     /codon_start=1
                     /gene="srtA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000078846.1"
                     /locus_tag="EQH27_RS05575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_05930"
                     /product="sortase SrtA"
                     /protein_id="WP_000078846.1"
                     /transl_table=11
                     /translation="MSQKNNKKKNKRKNLLTNILAGFLILLSLALIFNTQIRNIFIVWN
                     TNKYQVSQVSKEKLEENQDTEGNFDFDSVKAISSEAVLTSQWDAQKLPVIGGIAIPELE
                     MNLPIFKGLDNVNLFYGAGTMKREQVMGEGNYSLASHHIFGVDNANKMLFSPLDNAKNG
                     MKIYLTDKNKVYTYEIREVKRVTPDRVDEVDDRDGVNEITLVTCEDLAATERIIVKGDL
                     KETKDYSQTSDEILTAFNQPYKQFY"
ORIGIN
        1 ttctaggaat atctaccttg tagaaagtgt caccatgttt ggcaaaagta ccgttggcac
       61 caagtgaaac gataatccat tcaatccctg caaacaaagg ttcttgaagt acttctttta
      121 attcatccaa atcctcagaa acttctcttc caagaagctg agacaattct tcattatttg
      181 gtttgatgac tgttggttta tggggtgatt caagaacagc ctgaagtgct gcacctgagc
      241 agtccaagac tacaggcttg ccagcttgat tagcaagttc taccaagctc gcatagtaat
      301 caactggaag gccagctggc agactacctg agatggccac tacttcaact gactccaaga
      361 gttttttgaa atgttccaaa aagtcttgac cttcctgttc caatacttca ggaccttttt
      421 caagaacttc tgtttggttg tctccgtgga gaatagcgat acagttacga gtttctccct
      481 gaattgagaa gaaatctttc tttacttgat tatcgatatg ttcaaccaaa aactcaccaa
      541 gtttgccacc cactaaacca gtagcaagaa cagaatcgcc aaattctgaa agtactcggg
      601 taacattgag tcccttacca ccagccgttt tggttacatc caccacacga ttgacagtat
      661 caatcttcaa ctcatccaag ggataggaaa tatcaatgga tgggttcatt gtgactgtta
      721 aaatcatagg tcacctctta gtcgtggtat tctccgcgat cccatttttc aaggaattct
      781 gtaaagaagt ttgcgtctgt ttgttgagca ttgtgacttt caaggtgttc aattttcgca
      841 atcaatttct tgttttcttc agatggtttg tattcagcat gaatgaaagc ttcgatgata
      901 tcacacataa gcaattcacc agtaatctta ccaccaaagc cgataacgtt agcgttcaat
      961 tgttctttag cataaagggc tgttgtcata tcacgaacca aggcagaacg aacacctgga
     1021 actttattta cagcgttgtt gataccaaca ccagtaccac agatacatac cccaagatca
     1081 gcttggccgc tagttacagc ttcccctact tttttaccaa agattgggta gtgagtccgt
     1141 gtatggtcat atgtaccaaa gtcaatgact tcatatcctt ttgatttcaa aaattctgaa
     1201 accgccattt tttcatctgt tacgatgtgg tcgcatccaa ttgcaattct catttttaac
     1261 ttacctttct tactgtaatc taattagccc attttgttca acatgtcgac ccggatttga
     1321 tgacgtccac catcgtattt accgttaaca aatcctttag cgatgttttt agccaattca
     1381 tcaccaacaa gttgtgcacc catagtgatc atacgtgagt tgttgtggcc acgagtcata
     1441 taagctgaac gttcgtcaga tacttctgca gcaaccattc ctttgatctt agttgcaacc
     1501 ataaatggac cagctccata agcatcaatc acgataccaa ggttttgttc ttctttgttt
     1561 acttctgcag caacagcgag agtcacatca acaaagtctt gaccttcagc tgtaacatcc
     1621 acaaggtgga agttttcttt ttctaagaag tctttcacaa cttctttcaa tctcaaacct
     1681 gcagcatctg caccgataac aatagacata ttgtatactc ctttttattt tttctatgct
     1741 ggattccagc agtgtattgg ctgtctttaa aaaacagtca attagtcctc acaaacataa
     1801 tatactacta ttgtttgaag aagtcaacag tttgtgtttg tttttgttat ttatttttta
     1861 cttttttata aaacttctat ctcaaaccct aattcttcaa cctgattggc ttctaagaga
     1921 caaacattct tcttatcttc taaatgatct ccttcttcaa ggaatgttga caagccagac
     1981 catggttcaa aggtaatgaa aggtcccttg ttcaaagttg accagatgat gaggtttgga
     2041 aattctgcaa aatgcacttt caatccccta tcatgtttaa gagaacgaag ggcaattgtt
     2101 cgagattgca attcatccaa agtcactgca tctttgctga aaagatcata actaagatct
     2161 atttcttttt gtccctctag ccatggactt ctatcttgga aatccaacat acctgtttct
     2221 gggaaaggac gtggaacaga gcaagtctct tctttctcaa actctagata ataatcttca
     2281 tagacttcat catcaagtag aggacaatta aatcctggat gtccaccaat aaagtaaggc
     2341 ctgaccttgc tagtttcttt attagacttc ctgcaaaact agaatcctag ttcatgattg
     2401 ataatgccag caatcaaatt cattcgtaat ccgaagcgtt tacgatgatt tcgataggtt
     2461 gttgaaatca ttttaaacgt ttttactttg gcaaagatgt tctcaacctt gcttctctcc
     2521 ttagatagcg catggttata ggttttatct tcaactgtta gcggcttgag tttgctggat
     2581 ttacgtggag tttgtacttg aggatatatc ttcatgagcc cttgataact actgtcaacc
     2641 aagattttac cagcttgtcc gatatttctg cgactcattt tgaacaactt catatcatga
     2701 caatagttca cagtgatatc caaagaaaca atctcccttg acttgtgaca atcgcttgag
     2761 ccttcatagc gtggcatttc tttttaccag aatcattcgc taattctttt ttagggcgat
     2821 tgatttgtac ttccgtcgca tcaatcatta ccgtgtcctc agaactgaga ggagttcttg
     2881 aaatcgtaaa accactttga acaagagtta cttcaaccca ttagctccga cggagtaagt
     2941 tgctttcgtg gataccaaaa tcagccgcaa tttcttcata agttcgatat tctcgcacat
     3001 attgaagagt ggccataaga aggtcttcta ggcttaattt aggttttcgt ccaccttttg
     3061 cgtgtttaag ttgataagct gtttttaata cagctaacat ctctttaaaa gtggtacgct
     3121 gaacaccaac aagacgctta aatcgtgcat cagttagttg tttacttgct tcatcattca
     3181 tagaactact ataccatatt ttatttcgca ggaagtctaa tattgtcaaa tactggaacg
     3241 ctcattgctg ggatacagaa taagattggc ccagcttcga taactgggat acctggttca
     3301 aaaccaaggt ctgttgcagc gattggtgta aagatatcgt aacctttcat aaggtcttcg
     3361 tttacatctt tcaccataac tgcatcacag tgaacatcgt aaccacggtt tgaaagttct
     3421 tcttctagag cacttttaat ttggtgactt gagttaacac ctgcaccgca ggcagcaaga
     3481 attttaatca tatagacttc ctccgatttt attttttaat aaacaagatt aagcgattgc
     3541 ttcatctata taagcataaa gtttttctgg ttcggaaatt tttgataggt cttcaagatg
     3601 tccatttcct gtgaagaagt tcatcaactg agcaagaatg ttcgtttgac ttgaacttga
     3661 attattaatg ataaagaaga gtagggatac ttctacttcc ttatcgggag ctatcatatt
     3721 gtgaaaagtt actggttttt ctaatcgaac aaccaccact ttctcagcta gattatgaac
     3781 aatatctgtg tgaggaatcg ctacatttgg caagtccttt cctagaaatt ccatatctaa
     3841 accagttgga aatgactttt cacgcgtgat caaggcttca cgataagtag gagtgacaat
     3901 ttctcgttct tccaacaagc ttgctacctg atcaaagagt tgttcttgat tatccgcttc
     3961 taagcaaaac acaaggtttt tgtcaaagaa ataatctaat accataaggt tttcccttct
     4021 ttccattaac tttatgccat aagtataaca ctatatgaaa tcgttgttaa ttactttctg
     4081 ttcttttttt gtctcttttt tatatttttg ttttgtttat agtttgttat ataaaaataa
     4141 atacacaaac aaatactcca agcatttttc tgttctaata ctcaatgaaa atcaaagagc
     4201 aaactaggaa gctagccgca ggttactcaa aacacagttt tgaggttgta gatgaaactg
     4261 acgaagtcag ctcaaaacat gattttgagg ttgtagatga aactgacgaa gtcagtaacc
     4321 atacatacgg taaggcgacg ctgacgtggt ttgaagagat tttcgaagag tataaaaact
     4381 aaaaaagcag accatctaag cctgctttac tattgattct tatataaatt tcctgtgaac
     4441 aaggaaaggc atttctgata acttattctt catccatact caagacgctg aggaaggctt
     4501 cttgcggaac ttcaactgat ccgatggatt tcatgcgttt cttaccagct ttttgttttt
     4561 caaggagttt acgcttacga gaaacgtcac caccataaca tttagcaagt acgttcttac
     4621 gaagggcctt gatatcagta cgagcgacaa tcttgtgtcc aatagccgct tggattggaa
     4681 cttcaaattg ttggcgaggg atgattttct tgagtttatc aacgatgagt ttcccacgtt
     4741 cgtaggcaaa gtccttgtga acgataaagc tgagggcatc caccttatct ccattgagaa
     4801 ggatatccat tttcaccagc ttagatgggc gatattctga caattcgtag tcaaagcttg
     4861 cataaccacg tgtcgaagac ttaagtttat caaagaagtc aaagacaatt tcagcaagag
     4921 gaatttgata gataacattg acacggttat catcaatata gtccatagtc acaaagtccc
     4981 cacgcttacg ctgagctagc tccattactg ctccgacgaa ctcctgtggt accatgattt
     5041 gcgccttgac ataaggctct tcaatggtcg caatcttagt tgggtctgga aactcagatg
     5101 ggttagacac atccatagac tcaccgtcgg tcaaattaac tttgtaaata acagacggag
     5161 ctgtcatgat gaggtcaata ttgaactcac gctctaaacg ttcctggata acatccatat
     5221 ggagaagtcc aagaaatcca caacggaaac caaatccaag tgcctgagat gtttctggtt
     5281 caaactgaag actagcatca ttcagttgca atttttcaag cgcttcacgc aggtcattgt
     5341 atttgtttga ttcgattggg tagagacccg caaagaccat aggattcatc tgcttataac
     5401 catgtaatgg ttctgccgca ggattggttg ccaaggtaac ggtatcaccc acacgagtat
     5461 cctgaaccgt cttgatagac gctgcaatgt aaccaacatc accagtcgca aggaaatcac
     5521 gaccaaccgc ttttggtgta aaaataccga cttcggccac atcaaaggtc ttactattgc
     5581 tcatgagctg aatcttatca ccaggtttga ccactccgtc catgacacgc acttggagga
     5641 taaccccacg gtaagcatcg taaacagagt cgaaaatcaa ggccttaagt ggcgccgtca
     5701 catcacccgt tggtgctggt actttttcta caatttgctc gaggatttct tcaatcccaa
     5761 taccagcctt ggcagaagcc aaaactgctt cactggcatc caaaccaatc acatcttcaa
     5821 tctctgtacg cacgcgctcc ggatctgcag ccggcaggtc aattttatta atgataggca
     5881 tgatttccaa atcattatcc aaagccagat aaacgttggc aagagtttga gcctcaattc
     5941 cttgagccgc atcgaccacc aaaatagcac cctcacaggc agctagcgaa cgtgaaactt
     6001 cataggtaaa gtcaacgtgc cctggtgtgt caatcaaatg gaaaatataa gtttccccat
     6061 cttttgcagt gtaattcaac tcgatggcat tcaacttaat agtaattcca cgttcccgct
     6121 ctagctccat gctatccaaa agctgggcct gcatttcacg acttgaaacc gtctctgttt
     6181 tttccaaaat gcggtctgct agagttgatt ttccatggtc aatatgggcg ataatagaga
     6241 agttacggat cttctcctgt cgttttttca attcttctaa gttcatgatt ctcttccttt
     6301 cagggtatct atttattata aattgttttt gatattttga caagaccata ccctgctagg
     6361 agtactaatc ttcagcgaca aagccgtcat tttcgataaa gtggtgttct gtcattcctt
     6421 ggtctgtaaa gacaatcccg tgaaggacac caccataaac agctcctcca tccattccaa
     6481 tcttgccatc ttctgtagtc caaagctcag atgtaccgcg ttcttgctgt aacaaaccat
     6541 agaccggtgt atgaccgaag acaatggttt ttccagtatg attttcagct ccgtggaatg
     6601 gttttctaag ccatactttt ttataatctg ttgtttcatg ccagtcgtcc aaagtcaaat
     6661 caatacctgc gtgaacaaat atatacttgt ctgtctctac tacaaatggc atttgacgaa
     6721 tgaattcgac caagtctgac gcttcagcgg caacccgctt ggcatcttct actccatcaa
     6781 ctggtgcatc caagggacga cctaggatag agttaatggt tgtatctcca ccattgcgac
     6841 gataatggtc ataactttct tctgggtcat ctagccaagt caaaaacata tactcgtggt
     6901 ttccagacaa acagatagcc ccttgattgt ccaccaagtc cttgaccatt tcaagaacac
     6961 ggtgactatc ctcacctctg tcaatcaaat cacctagaaa gagcaactgg gtcttaccat
     7021 cccaggtttt gagaaggtct tccagcatcc cagcttttcc gtgaacatct ccaattacat
     7081 aatagtctgt catcttattt ctccctgttt ctcaacaatt ctctggcttg cgtcagggct
     7141 gcttctgtca catcatcacc tgccaacatc ttggcaactt cctccactcg ctcttcgacc
     7201 gtcaaaagac gaacagtcga aaccgttgaa tggtcattac taatcttctc aataaagaat
     7261 tgataatctg caatcgcaat tacttgtggc aaatgggaga tagccaaaac ctgaccatgc
     7321 tgaccaattt tatgaatttt ctgagcaata gcttgagcaa cacgacctga aactcccgta
     7381 tccacctcat caaagacaat gctagtcttg ccttctttac gtgaaaaggc agacttaatg
     7441 gctaacatga gacgagataa ttcccctcca gaagcaacct taaccaaggg tttaaagtct
     7501 tctccagggt tggttgaaat ataaaactca accatttcat ttccctcacg actgaatttt
     7561 cccttactaa aacgaacctg aaactgggct ttttccatat aaagatcttg cagttcttgt
     7621 ttaatctcag cttcgagttg ctgagccaaa ttatgacggg cagaagcaag ttgacctgcc
     7681 aaattgacaa gattgacttc caacttctta agctctgctt ccatgtcctc agacgaaaga
     7741 ttattgcctg tcaagagatt gtattcttcc gtaatcttag caaaataaag caaaacatca
     7801 tcaacagtcc caccatactt acgagtaata gtatgaagga ggtccaaacg attctcaacc
     7861 tgcatcaggc gattgccatc aaaatcaagg tcctcaatga tagcttccaa acgtttgcta
     7921 atgtcttcta aaacatagta ggtctcagac agagagcttg aaatttcacg gtattcagaa
     7981 tcatactctt cgacactttc catgtcattc atagctgaac gaacattggc cagacttgaa
     8041 aaatcttcat tgtccaacat actgtaggca ttggtcagtg tatccgcaat atttttgtgg
     8101 ttgaggagtt tatctcgctc ttgattgaga gccaagtctt ctccagcctg caagtttgct
     8161 gcctcaatct ctgccatttg aaattccaac atttcgatac gtgccttgtg ttcctgttgg
     8221 tttttcttga cttccagaac ctgcttgcgc attttccgat aggcatcaaa actcgtttga
     8281 taggtttctt tcaagtccca aaaagcggca tcaccaaatt catccaacat ctggatatgc
     8341 agttggggac gcattaactc ctcatggtca tgctgaccat gaatatctac aagatgttgc
     8401 ccaatagctc gcaaaacaga cagattaacc atctgaccat ttacacggct gatactacga
     8461 ccattttgca agatttcccg acggatgata atttcatcac ctaattctaa accttgctca
     8521 tcaaaaattt cctgtaaaag acgactattc tcaactgaga aaagcccctc aatctctgcc
     8581 tttggtgcac catgacgaat aacatctgtc gtcgcacgag ctcccaacat catattcatg
     8641 gcatcaatga taatcgactt ccctgcaccc gtttcaccag tcaggacagt catccccttt
     8701 tcaaaattga gggaaatagc ctcaataatg gcaaagtttt ttatcgaaat ttcaagtaac
     8761 atatagacct accaattttt tacttgttca aagatttcct ctgctagact tccacttctg
     8821 gcaatgacta aaatcgagct atcatcagtc aaacaactaa aaatcttgtc tgcaaaagta
     8881 tcgattaact gagcttttac aaaagccgta tttcctggaa taacttggag attgatcatc
     8941 ttatccatca attcagccga ttcgatattg tcttcagcca gttgcagact ttttacgatt
     9001 gattttggta attcgtagac ataggtgttg tctctcaaag gaattttgac aatacctaac
     9061 tctttgatat ctcgggatac cgtcgcctga gtggcagtga tacctgcttc tttcaaatgt
     9121 tctacaattt cttcttgcgt gccgatttga taatctgtca ccaatcttct aattttttca
     9181 agtctctctt ttttattcat ttttaaattg actatgcgcc ctctctactg cttctttaat
     9241 ctcagcaaga atctgattgc ttgctgactt ttcttttttc aaatacgcta aaaattcaat
     9301 atttccatgt ccaccttgga tgggagaaaa gtccaagcca aggactgaaa aacctacctc
     9361 tactgccata gctgttacag attcaaggac attctgatga accttagcat ctcgaataat
     9421 tccatttttc ccaatctgct cacgtcctgc ctcaaactga ggtttgacaa gtgctaccac
     9481 ctgaccttga tcagccaaga cacggtgcaa ggctggcaaa atcagactaa gggaaatgaa
     9541 actcacatca atactggcaa agctcggctc ctgctcgaaa tcagtctttt cagcatagcg
     9601 gaaattgaac tgctccatgc tgacaactcg tgggtcttgg cgtaatttcc aagccaactg
     9661 attggtacca acatcgactg caaagaccaa cttggcacta ttctgtagca tgacatcggt
     9721 aaaacctcca gtagaggccc cgatatcaat cgtagtcgcg ccatccaccg acaaatcaaa
     9781 gacctgcaag gccttttcca gtttcaaacc accacggctg acatacttga gtttctcccc
     9841 cttgagtttt aattcggtat catctggaat tttctctcct ggcttgtcaa accgttctcc
     9901 attaaggact gctacgacta ggccagccat cacacctcgc ttggcctgct ctctcgtttc
     9961 aaacaacccc tgtttataag ctagtacatc cactctttcc ttagccattg attctcaaac
    10021 tttctactac acttacaatc gattctgttt caaagggaac ctgctgggca atttcttcca
    10081 atttttcatt agcttgatcc agggtttggt tacaaaaggc aatggactct tccaagccca
    10141 acaaggcagg ataggttgat ttttctgcct gcagatcctt ttgaggtgtc ttaccgattt
    10201 cctcaaaact agctgtcaca tccagtacat catctctgac ttgaaaagca agtccaatca
    10261 attcacccac agttttcagc ttcacctgca tttcaggtga caattcagct ataatagctg
    10321 ccgcttggaa gggataggct agtaacttcc cagtcttatt ggcatgaata gtctgaagtt
    10381 cttccagaga caagtgctgg tgttcgccct ccatatccaa aacttgccct gccaccatac
    10441 ccagactacc tgaagcaagg gataagttgg caatcaagtc caccttgatc tgacttggca
    10501 aatctgcctg cgcaatcaag gcatatgggt ctaagaataa ggcatctcca gccaaaatgg
    10561 ccatagcttc accgaatttc ttgtgattgg ttaaccgccc tcttcgataa tcgtcatcat
    10621 ccatagcagg aaggtcatcg tgaatcaagc tccctgtatg aatcatctcc aaggcagtag
    10681 ctacctgcgc gtgagcaggt ttgatggcaa cctgcaaggc ttccagaact tctaacaaga
    10741 gaaaaggccg aatacgcttg ccaccagcat gaatagaata gagaacagac tcccgtaaac
    10801 tagaggcaaa ctgctggtct ccataaaaat cttccaaagc cgactcgaca agagctaatt
    10861 tttcttgctt tttcattcaa aatcactttc tgttccgtct tcttgcatga ccttgaccaa
    10921 ggtcttttca gccttgtcca gcgtagcttg gagctctttt gacaagacca tgcccttttg
    10981 aaaggcagta atcgcatctt ccagagcaat ttcaccattt tccaaacttt ggacaatggt
    11041 ttccagttct gctagatttt cctcaaattt cttttgtttt gacatcttta acctctaatt
    11101 ctacttgacc atctcgcatc aaaagcgtta cttggtcttt tttcttcaaa ctctcaaccg
    11161 aatctacaac ggactcttct tttttgacaa tagcataacc acgcgccacg attcggctag
    11221 tatccaacat gagcaaagct tccgaaagtc gcttggcctc agcaaccttg gcgtcataaa
    11281 ctaacgccat ttggctacct aagagcttgt ccaactgtcc taaacggtct tgatagcgtt
    11341 ggattttggt aacaggtgat aattgtacta attgatgagt tcttgcttga actaattgtt
    11401 tgttatcaga aatccgagtt cgcaaacttt gcttcaaacg cagttgcagt tggtccaagc
    11461 gttgcaaata accgtcatac aagcgctcag gttgtctaaa gataacagac tgactgcatt
    11521 ttttcaaagc ctcttgtttc ttagatagaa catttcggac tgccgttgcc atccgttttt
    11581 cctgattttg caaatgagct aatacatcca acttggtcac aggtgttgcc agttcagccg
    11641 ccgctgttgg cgttgcagcg cgtcgatctg ccacaaaatc tgccaaggtc acatccgtct
    11701 catgccccac actagagata actggcaaac gagattcaaa aatagctcgt accacaattt
    11761 cttcgttaaa ggcccagaga tcctcaatag aaccacctcc acgaccaata atgagcaaat
    11821 ccaaatcatc ccgttgatta gcacgcgcaa tatttctagc aatttcctcc gcagcccctt
    11881 caccttgaac cttggtcgga taaagaagga tgtcaacacc tgggaatcgc ctgctgacgg
    11941 tcgtgataat atctcgaata acggctccac tacggctggt tactacacca attctcttag
    12001 aaaattgggg cagagcttgc ttgaagcgtt cttgaaacag gccttcttct gtcaattttt
    12061 tcttaagttg ttcaaactga atcgcaagcg ccccaacccc atcaggctca gctttttcaa
    12121 tgatgatgga gtagctacca cttagttcat agacctgtac acgcccaatc acattgatct
    12181 tcattccttc ttccaggtca aaccctaatt tctgataaat cccagaccag atggtcgctt
    12241 gaataactgc atggtcatcc tttagggaga aatattggtg agtaggtcgt ttacgaaagt
    12301 tggaaacttg accagttaaa tagacccgtt ccaagtatgg gtctttatcg aatttcattt
    12361 tcagatactt ggtcaaagtt gttaccgata aatacttttc catctccacc tactattcat
    12421 ttacttgctc tttcatgggt attattatac caaaaatatg cctaaaaatc tccatttatg
    12481 taccattatg agggaaaaat agaaaaagga ggcaaggcct ccacatgtga ttatttgctg
    12541 tttcgagctt cttccaaaat ctttgcaatc ttggtcgtca acaggtcgat agccacggta
    12601 ttgctaaccc cttcaggaat gacgatatca gcataacgct tagttgactc gataaactgg
    12661 tggtacattg gtttgaccac acctaagtac tggttaataa cgctatcaag gctacggcca
    12721 cgctcctcca tatcacgctt gatacgacga ataatgcgca catcgtcatc cgtatccaca
    12781 aaaatcttga tatccatcaa atcgcgcaga cgcttgtcct ccaagaccaa aatgccctca
    12841 acgataaaga catcttgagg ctcctgacga taggtcttgc tactccgtgt atgctctgta
    12901 tagtcgtagg tcgggatgtc caccggacgc cctgccaaca attccttaat ctgctcgatc
    12961 atcaagtctg tatcaaaggc aaaaggatgg tcatagttgg ttttgacacg ctcttcaaag
    13021 gtcaaatgag actgatcctt gtagtatgaa tcatgctcaa tcatggaaat cttttcatca
    13081 ggaaaatgcg ataaaatggc tcttgaaaca ctggttttac caccaccaga accacctgtc
    13141 actccaataa tgattggtct attttgcatg ctatcctccg ttattttatc cgtcgtctat
    13201 tctatcacat tttttacaaa atttatagtc tcatcagcaa aaaacaccag agtcttccct
    13261 ctgatgttcg acagttttaa cgaaagccct gtagggtttg agcaagcatc tgcaagaaag
    13321 ccagtctccc tctttcctgg ctaggagctt tggcaatcca taaaccaaaa tcaatgacag
    13381 acttaggtgc ctggtaatga tgcgtcatga ggtaaagtga caacccttga ctcaaattgg
    13441 ccatgaccgt ttggtatttt tcatttctgt ctaaattttg tatagcaaga cgaaacaggt
    13501 gactcaactc actattttca tttatttctt tttgttgaag aagttgctcc accctttctc
    13561 gaaactcatt tcgcatcatg gaattatcac accaaatcct gggcctaagt tcccaccaga
    13621 acctgtaatg gactctaaat atttatctga aagaatttta aattgcttca tttcacacct
    13681 ctaaatttct atatagatta tttgagtacc taatagatta tttgagtacc tacaactcgc
    13741 aacaattgga atattataat tcccaaaacc attctactat tagtatgggg ttttatcaag
    13801 caattattat ctatcacccg atttttattc ctaaacgatc tagctaaaaa ccttccttgg
    13861 cttatagaga ttgccccgtt tttctagaat ggctaacaat ttatcatctt caaaggcagc
    13921 cagttctttg tccgtttggt ctagctcaat aaaacgacca aagcgaactt ctgtagcctc
    13981 ttctggagtt aggaaaactt tgacaaggtc acctgtccca atctctaaag gacggagaaa
    14041 atctaattgc ccagcctcta ctttttcaac aatttcctcc aaggtaagag catcttctaa
    14101 ttgtaagcca gcagcactag tacgagtcaa atgggacata tgagccgcat aaccaagctt
    14161 ttcacccaaa tcaactgaca aagtacggat gtaagtccct ttactgcatt ttacacgaaa
    14221 agtgaatcgg gcaagttggc catcataaga aatcggactt gttcgctcaa attgataaat
    14281 ggtcacctga cgttctggac gctccacttc ctgaccagca cgcgcatact catagagctt
    14341 gcgaccatta accttaactg ccgaatacat agggggaatc tgagtaataa gcccagtcaa
    14401 gctagcaatc gcttcatcaa caagcttttc atccaaggga gacaaaacag gggtttctgc
    14461 gaccacttcc ccactagcat cctcagtcgt cgtggaatag cccagagtaa tttccccctc
    14521 atagatctta ccctcgtcct gcataaactc gaccatgcgt gtcgccttgc caaccgcaat
    14581 cggcaaaaca cccaccacat ccggatccaa ggttccacca tgaccaattt tcttggttcc
    14641 caaaatctta cgcagtttaa aaaccgcatc atgcgaggtc attcctgctt ctttttttaa
    14701 gttgataata ccgttcattt tgctttctac tcccccttca gtgcttcgaa cttcgctttc
    14761 attgttggat ttttccgggt caatttttta acagagacat cttccaattt gttgttagct
    14821 agacggagtt ggttttcaga tgtagtcagg aatttcttaa cctcttccat gcgtttgatg
    14881 gccttgtcga tttcatcaat agcttttcca aagttagtcg aagctgaatt atagttctta
    14941 gcaaaagcta gcttaaaggc atccaaatct tcctcaaaat gcgtaatgtc aatattttgc
    15001 tcgcgaacca aggccaactc ctgcttgtat tttagggaat ttagcgccgc attacgtaag
    15061 agaccaatca attggataaa gaattgagga cgaacaacat acattttttc atactcgtga
    15121 ctgacgtcaa caatccctgt gttaaagtag tcattatcag cctcaagcat ggtcaccaaa
    15181 acggcatact cacagttctt ctcccgacgg tccttgtcca attccttgta aaaatctgca
    15241 ttcttgtgct tcttctctgt tccgtccgct tcgtttttca tctcaaacat gatagaaatg
    15301 atttcaactc cattttcatc acactcacgg aagataaagt cccctttaga cccacgcgaa
    15361 gagaccttgt tatccttctc aaagtaagca tttggaaagg cgaaactacg aaccttgtta
    15421 aactcactct ctgcatactg ttctaggctt tccccaatcg cttttgtaga ttgttgagcc
    15481 ttaaaattct tataaaactc gacttgttca ctggctgctt tgagctgggc ttcgtagttt
    15541 tgcttaacag aagccaaaga caactcattt tccttttctt gcagtaggag ctgatttttg
    15601 acctgattgc gttctttttc taggtcagaa agggtctttt gcaattgatt ttcatgctcc
    15661 aaacgcaagg tcgccaactg gttttccaag gcctgtactt ccttgtcctt agccaataag
    15721 gcctgatggc ttgtctgttc aacttctttc ttggccaatt ctttttctgt atcaaagttt
    15781 tggatttgac tctgcaattg cgcaatttct tgatccttct gagccagttt agtctgttgc
    15841 tcattcatag ccttttgctc agccaaggcc agttcctgcc tcatcctatc gtgtagttcc
    15901 ttatcaaact ctgccgttct cacttgggac aaaagttcag catactggct ttcatttact
    15961 gtaaagactt ccccacagtt gggacatttg atttcgttca ttacattcct ctttctagac
    16021 ttctgtaacc attatatcat gcctgaggga aaatcaaaaa cagtgagtca aaacccactg
    16081 tttatcttct tttactttaa attttttcca aggccaagcg taagtcttca atcaaatctt
    16141 ctacattttc aagaccgatt gacagacgaa tttggtttgg tgtgacacct gctgcttcta
    16201 ggtctttttc tgacaattga ccgtgagtgg ttgttgctgg atggacaaca agcgatttag
    16261 catctgccgc gtttgcaagg tcagaaaaga tttctaaatt atcaatgacc ttgcgtgctt
    16321 cttcctcgtc acctttgacg tggaaggtaa agattgaacc gacacctttt ggcaagtatt
    16381 tctcagccaa ggcatgataa ggactatctg caagttttgg ataatttacc ttttctacct
    16441 taggatggtt gacaagaaaa tcaacaattg tctcagcatt ttgtacatgg cgttccacac
    16501 gaagtgaaag agtttcaagt ctttgtagca agaggaaagc attgaatggt gacaaggctg
    16561 cacctgtatc acgaagcaat tgaactcgaa cagctataat aaaggttgct gcacccacat
    16621 cacgaatata gctcaaattg tggcagcttg aaccctcgtc aacaaattga gggaatttcc
    16681 ctgaagccgt ccagtcaaaa cgaccactat cgacaattat tcctccaata gttgtaccat
    16741 gcccaccgat aaacttagtc gcagagtgaa tggcaatgtc aacgccatga gagaagacgt
    16801 taatcaaata aggtgttgca aaagtattgt ctgacacaag tgggatttga tgtttatgag
    16861 caatctctgc cagtttttcc aggtctggaa tattaatcaa ggagttaccc aaggtttcaa
    16921 tcaagacaag cttggtattg tctttgatag ctgcttctac ttcctccaaa ttatcaatat
    16981 cgacaaaggt tgttgtgata ccataacgag gaaggggttc tttcaaaaga ttgaaggttc
    17041 caccgtaaat agtcgaagca gccactacat ggtcaccagc atgggcaagc gccaaaatcg
    17101 tataagtcac tgcagtcata cctgatgctg ttgctagcgc ttcaacacca ccttcaaggg
    17161 cagctgttgt aggattggtg atacgagtat aaatgttccc tggtttcctc aaggcaaaca
    17221 gatcagcacc ttcctacgtg tcatcaaaaa caaaagatgt tgtttgataa atcggcactg
    17281 cacgagactc agtagctgga gtcacaactt gaccagcatg tagttgtaga gtttcaaatt
    17341 taaaatcacg agtcataagg tgacctccat attattttat taaggatatt gtagcacctt
    17401 gagttatagt ttacaaatat cagttttcta tattttgata taagaaatag ctattacctt
    17461 attttgaaaa tgaaaaaagc acgactcaat cgtgctcatt ttcttaatct acataagtat
    17521 cttcgttttt attgaggaag gcatatggaa gacccatcaa gaggcctcct ccgataaagt
    17581 ttccgatgaa agtcacaccc cagtggcgaa gcatatttcc aacaccgaag ttggcaattg
    17641 aatccgcagc aacactgaat ttcacaatcg cgaaagaagc aaagttcgcc gcaatgtgct
    17701 cgtttgttaa gaatacaaac atgtaaatag ctgacaacac aagccaaagt ttggcaccac
    17761 catctttgac caaaataaat gacagaatcg caatatttac gaaaatattt gccaaaatcg
    17821 cctcaagcaa gaccaattca tttgagcggc ctaacttcat ctcaacaaca cctgagatga
    17881 aactatcgtg tgtcagattc gcataggctg ccgaatgagc aaagccccac cctgctatca
    17941 aggatccgat aaggttgaac aaggtacagt atagtaaaat ctcagctgtt tttctccaag
    18001 agattttttt taagaaacta ccagcagtca agaacatcat gtttgaagtg accaactcgg
    18061 cattcaaaaa aacaatgtag gccaagcccc aagcaaaaac gaatggaaag aggaagcgtc
    18121 cactacctgg tgcaatttta ttaatcaagt cagccccaac tgcacctgca gcagtactga
    18181 aggttaaaaa tgcacctgcg aatatcgaac gaatcgcata cttaaatttg ctttgactat
    18241 aaagactttc tttcttattg caagcaaatt caatctttga gataaattct gaagaaatca
    18301 taataaactc ctaaatcttt tttcttgata attatatcac aaactttagg ttttaggaag
    18361 cgttttctgt atttcataaa agtttatagt agattgaaac tagaatagta cacctctact
    18421 tctaaaacat tgttagaaat cgatttgact gtcctgaacg attagtccta ttcttatttc
    18481 attttactat atttttatga aaatcttaaa aaatcagtga aatccatgat ttcactgatt
    18541 tgtattaata aaattgttta tatggttgat tgaaagctgt taggatttca tcagatgttt
    18601 gtgaataatc ttttgtttct ttcaaatcac ctttgacaat aatacgttct gtagcagcaa
    18661 ggtcttcaca ggttactaat gtgatttcat tgaccccatc tctatcatca acttcatcaa
    18721 cacgatctgg tgtcacacgt ttgacttcac gtatttcata agtataaact ttatttttat
    18781 cagttagata aatcttcatg ccatttttag cattatctaa aggagaaaat aacattttat
    18841 tagcattatc aacaccaaag atatggtgac tagctagact ataatttcct tctcccatta
    18901 cttgctcgcg tttcattgta ccagctccgt agaagagatt aacattatca agtcctttaa
    18961 aaatcggcaa attcatttcc aattcaggaa ttgcaattcc cccaataact ggtaattttt
    19021 gagcatccca ttgagaagtt agaacagctt ccgaagagat agctttgaca gaatcaaagt
    19081 caaaattgcc ttctgtatcc tgattttctt ctaatttttc ttttgatacc tggctaactt
    19141 gatacttatt ggtattccag actatgaaaa tatttcgaat ttgagtatta aaaatcaaag
    19201 ccagtgacag taatatcaga aatcctgcta ggatatttgt cagcagattt tttcgcttgt
    19261 ttttcttttt attatttttt tgagacatta tgcttcacct tctgtttcgt tttctgtccc
    19321 aacttcttct ttttctgcca ccgcaaccgt tgtgaaagtc actatctgag catcttgatc
    19381 caggcgcatt actttaactc ccatagttgc acgtcctgtt tgtgaaatat tggcaagatt
    19441 ggttcgaatc atgacacctg tatcagtgat aatcatcaaa tcctcatccc cttgaacagt
    19501 cataagaccg gccagcaagc catttttttc ggtaatttta gctgtctgca ttcccttacc
    19561 accacgacct tttgttgggt attcagtagc gactgtacgc ttaccatatc ctttttctgt
    19621 gataataaga acctcatctt gatcagtaat caagctggca ccaacaactg tgtctccttc
    19681 acgaaggtta acacctttca caccagtggc gatacgactc ataccacgaa cggctgattg
    19741 attaaagcga actgcataac caaacttggt accaatgata atatccatat ctccttctgc
    19801 caacaagaca ttgattaact catcttcatc ctttaaattc agcgctttga gaccattttg
    19861 acgaatattg gcaaactcct taacactagt tctcttcaca ataccgtgac gggttgtaaa
    19921 gaagagataa gcatcatcac tgcgatcaga ctcaacattg ataaccgtct gaatactttc
    19981 gtcttcatcc aatttcaaga gattgactac tggtagccct ttggcagtcc gaccatactc
    20041 aggaatttca taacctttaa gacgatagac acgtcccttg tttgtgaaga agagcagatg
    20101 atcatgggtg ctagttgaca ctaactcacg aacaaagtca tcatctttca ctcccgttcc
    20161 ttggacacca cgacccccac gtttttgagc agtgaactcg tcctgatcca aacgcttaat
    20221 gtagcctctg ttagaaaggg taatcaagac atccgattct tcaatcaagt cctcatcctc
    20281 gagactcaag acctgtccaa tcatcaactc tgtacggcgc ttatcagaaa atttacgttt
    20341 aacttcatcc aattcgtctt tgataatttg agaaacacgt tcaggcttag caagaatatc
    20401 tgctaaatcc gcaatcagag ccaagaggtc atcatactca gattgaatct tatcgcgttc
    20461 caaacctgtc aaacgacgaa gacgcatatc aaggatagct tgactttgac gttcagaaag
    20521 cttaaacttg ctcatcaact cagcttgagc ttccgcatcc gtttcactag cacggatgat
    20581 acgaatcact tcgtcgatat ggtctagcgc aatcaagaga ccttctaaga tatgagcgcg
    20641 cgcttccgct ttttccttat caaaacgtgt acgacgaaca accacttctt tttggtgctc
    20701 gatataagca tccaaaatct gacgaagaga caaaattttc ggtataccat tttggatagc
    20761 gagcatattg aaaccaaaat tggtttgcat ttgggtcatt ttgaagaggt tattgagaat
    20821 aacattggct gaggcgtcgc gcttgacttc aataacaaat cgaacacctt cacggt
//
