LOCUS       NZ_CP035253            14164 bp    DNA     circular CON 19-DEC-2024
DEFINITION  Streptococcus pneumoniae strain TVO_1901933 chromosome.
ACCESSION   NZ_CP035253
VERSION     NZ_CP035253.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1  (bases 1 to 2130843)
  AUTHORS   Rosconi,F., Cotton,S.L., Kempchinsky,A., Surujon,D., Johnston,C.D.
            and van Opijnen,T.
  TITLE     Streptococcus pneumoniae DNA-modification patterns determined at the
            pan-genome level
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2130843)
  AUTHORS   Rosconi,F., Cotton,S.L., Kempchinsky,A., Surujon,D., Johnston,C.D.
            and van Opijnen,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JAN-2019) Biology, Boston College, 140 Commonwealth
            Avenue, Boston, MA 02467, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 05-NOV-2018
            Assembly Method                   :: HGAP v. 4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 299x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022070145.1-RS_2024_12_19
            Annotation Date                   :: 12/19/2024 10:37:21
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,215
            CDSs (total)                      :: 2,141
            Genes (coding)                    :: 1,992
            CDSs (with protein)               :: 1,992
            Genes (RNA)                       :: 74
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 149
            CDSs (without protein)            :: 149
            Pseudo Genes (ambiguous residues) :: 0 of 149
            Pseudo Genes (frameshifted)       :: 69 of 149
            Pseudo Genes (incomplete)         :: 70 of 149
            Pseudo Genes (internal stop)      :: 56 of 149
            Pseudo Genes (multiple problems)  :: 39 of 149
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:26:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 482787
            Orig. end                         :: 496951
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP035253.1.
            Genome not circularized.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..14164
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..14164
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..14164
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:9164]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9164
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(71..87)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 23.21"
                     /tool="antismash"
     gene            326..1666
                     /locus_tag="EQH27_RS02450"
                     /old_locus_tag="EQH27_02625"
     CDS             326..1666
                     /EC_number="2.7.13.3"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000275284.1"
                     /locus_tag="EQH27_RS02450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_02625"
                     /product="sensor histidine kinase"
                     /protein_id="WP_000275285.1"
                     /transl_table=11
                     /translation="MYIFWIILYTLITNGLEIVIFFKVDGIGLTFERIFKAFLLKILLA
                     FVFVMIGYMVGNVYLSYFMEPLYGIGLSFLLLRGLPKKLLFFYGLFPMILVNLFYRGVS
                     YFVLPFLGQEQVYDGYSFTGLCIIIFNFFISLAFLKWLDYDFTSLRREILDTGFQKSLT
                     KINWIMGAYYLVIQSLSYFEYEQGIQSTTVRHLILVFYLLFFMGVIKKLDTYLKDKLHD
                     RLDQEQVLRYRDMERYSRHIEELYKEVRSFRHDYTNLLTSLRLGIEEEDMEQIKEVYDL
                     VLKDSSKKLQDNKYDLGRLVNVRDRALKSLLAGKFIKAREKDIVFNVEVPEEIQVEGMR
                     LLDFLTIVSILCDNAIEASAEAGQPHVSIAFLKSGAQETFIIENSIKEEGIDISEIFSF
                     GVSSKGEERGVGLYTVMKIVESYPNASLNTTCQDQVFRQVLTMIPTE"
     misc_feature    complement(341..359)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 25.73"
                     /tool="antismash"
     gene            complement(1710..1865)
                     /gene="blpC"
                     /locus_tag="EQH27_RS02455"
                     /old_locus_tag="EQH27_02630"
     CDS             complement(1710..1865)
                     /codon_start=1
                     /gene="blpC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000358812.1"
                     /locus_tag="EQH27_RS02455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_02630"
                     /product="quorum-sensing system pheromone BlpC"
                     /protein_id="WP_000358814.1"
                     /transl_table=11
                     /translation="MDKKQNLTSFQELTTTELNQITGGGLWEDILYSLNIIKHNNTKGL
                     HHPIQL"
     misc_feature    complement(2010..2027)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 23.05"
                     /tool="antismash"
     gene            2063..3409
                     /locus_tag="EQH27_RS02460"
                     /old_locus_tag="EQH27_02635"
     CDS             2063..3409
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808790.1"
                     /locus_tag="EQH27_RS02460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_02635"
                     /product="IS1380-like element ISSpn5 family transposase"
                     /protein_id="WP_001809444.1"
                     /transl_table=11
                     /translation="MNSLPNHHFQNKSFYQLSFDGGHLTQYGGLIFFQELFSQLKLKER
                     ISKYLVTNDQRRYCRYSDSDILVQFLFQLLTGYGTDYACKELSADAYFPKLLEGGQLAS
                     QPTLSRFLSRTDEETVHSLRCLNLELVEFFLQFHQLNQLIVDIDSTHFTTYGKQEGVAY
                     NAHYRAHGYHPLYAFEGKTGYCFNAQLRPGNRYCSEEADSFITPVLERFNQLLFRMDSG
                     FATPKLYDLIEKTGQYYLIKLKKNTVLSRLGDLSLPCPQDEDLTILPHSAYSETLYQAG
                     SWSHKRRVCQFSERKEGNLFYDVISLVTNMTSGTSQDQFQLYRGRGQAENFIKEMKEGF
                     FGDKTDSSTLIKNEVRMMMSCIAYNLYLFLKHLAGGDFQTLTIKRFRHLFLHVVGKCVR
                     TGRKQLLKLSSLYAYSELFSALYSRIRKVNLNLPVPYEPPGRKASLMMH"
     gene            complement(3629..4990)
                     /locus_tag="EQH27_RS02465"
                     /old_locus_tag="EQH27_02640"
     CDS             complement(3629..4990)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001069090.1"
                     /locus_tag="EQH27_RS02465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_02640"
                     /product="bacteriocin secretion accessory protein"
                     /protein_id="WP_001069093.1"
                     /transl_table=11
                     /translation="MNPNLFRSVEFYQRRYHNYATVLIIPLSLLFTFILIFSLVATKEI
                     TVTSQGEITPTSVIASIQSTSDNPILANHLVANQVVEKGDLLIKYSETMEESQKTALAT
                     QLQRLEKQKEGLGILKQSLEKATDLFSGEDEFGYHNTFMNFTKQSHDIELGISKTNTEV
                     SNQANLANSSSSAIEQEITKVQQQIGEYQELRDAIINNRARLPTGNPHQSILNRYLIVS
                     QEQTQGTAEEPFLSQINQSIAGLESSIASLKIQQAGIGSVATYDNSLATKIEVLRTQFL
                     QTASQQQLTVENQLTELKVQLDQATQRLGNNTLTAPSKGIVHLNSEFEGKNRIPTGTEI
                     AQIFPIITDTREVLITYYVASDYLPLLDKGQTVRLKLEKIGNHGTTIIGQLQTIDQTPT
                     RTEQGNLFKLTALAKLSNEDSKLIQYGLQGRVTSVTAKKTYFDYFKDKILTHSD"
     gene            complement(5001..6677)
                     /locus_tag="EQH27_RS02470"
                     /old_locus_tag="EQH27_02645"
     CDS             complement(5001..6677)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_function="GO:0008234 - cysteine-type peptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0043214 - ABC-type bacteriocin transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0043213 - bacteriocin transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR01193.1"
                     /locus_tag="EQH27_RS02470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_02645"
                     /product="peptide cleavage/export ABC transporter"
                     /protein_id="WP_307774213.1"
                     /sec_met_domain="TIGR01193 (E-value: 1.6e-263, bitscore:
                     873.3, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIFKQKSLIAYIVLSSLLVTIINIGGSYYLQGILDEYIPNQMKST
                     LGIISVGLVITYILQQVMSFSRDYLLTVLSQRLSIDVILSYIRHIFELPMSFFATRRTG
                     EIISRFTDANSIIDALASTILSLFLDVSILILVGGVLLAQNPNLFLLSLISIPIYMFII
                     FSFMKPFEKMNHDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQNIDSEFVDYLEKS
                     FKLSKYSILQTSLKQGTKLVLNILILWFGAQLVMSSKISIGQLITFNTLFSYFTTPMEN
                     IINLQTKLQSAKVANNRLNEVYLVESEFQVQENPVHSHFLMGDIEFDDLSYKYGFGRDT
                     LTDINLTIKQGDKVSLVGVSGSGKTTLAKMIVNFFEPYKGHISINHQDIKNIDKKVLRR
                     HINYLPQQAYIFNGSILENLTLGGNHMISQEDILKACEVAEIRQDIERMPMGYQTQLSD
                     GAGLSGGQKQRIALARALLTKAPVLILDEATSGLDVLTEKKVIDNLISLTDKTILFVAH
                     RLSIAERTNRVIVLDQGKIIEVGSHQELMQAQGFYHHLFNK"
     gene            complement(6571..7158)
                     /locus_tag="EQH27_RS11055"
     CDS             complement(6571..7158)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001855030.1"
                     /locus_tag="EQH27_RS11055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cysteine peptidase family C39 domain-containing
                     protein"
                     /protein_id="WP_000205166.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.2e-41, bitscore:
                     138.6, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTN
                     KEGTTALGIVKAADEMGFETRPVQADKTLFDMSDVPYPFIVHVNKEGKLQHYYVVYQTK
                     KDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPSSDF
                     QTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG"
     gene            7440..7637
                     /gene="blpI"
                     /locus_tag="EQH27_RS02475"
                     /old_locus_tag="EQH27_02650"
     CDS             7440..7637
                     /codon_start=1
                     /gene="blpI"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093259.1"
                     /locus_tag="EQH27_RS02475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_02650"
                     /product="bacteriocin-like peptide BlpI"
                     /protein_id="WP_001093259.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 3e-10, bitscore:
                     37.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKMMEQFSVMDNEELEIVSGGRGNLGSAIGGCIGAVLLAAATG
                     PITGGAATLICVGSGIMSSL"
     gene            8104..8373
                     /gene="blpJ"
                     /locus_tag="EQH27_RS02480"
                     /old_locus_tag="EQH27_02660"
     CDS             8104..8373
                     /codon_start=1
                     /gene="blpJ"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093248.1"
                     /locus_tag="EQH27_RS02480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_02660"
                     /product="bacteriocin-like peptide BlpJ"
                     /protein_id="WP_001093248.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 2.1e-18,
                     bitscore: 63.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKMLSQLEVMDTEMLAKVEGGYSSTDCQNALITGVTTGIITGG
                     TGAGLATLGVAGLAGAFVGAHIGAIGGGLTCLGGMVGDKLGLSW"
     gene            8442..8690
                     /gene="blpK"
                     /locus_tag="EQH27_RS02485"
                     /old_locus_tag="EQH27_02665"
     CDS             8442..8690
                     /codon_start=1
                     /gene="blpK"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000379965.1"
                     /locus_tag="EQH27_RS02485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_02665"
                     /product="bacteriocin-like peptide BlpK"
                     /protein_id="WP_000379965.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 8.7e-11,
                     bitscore: 39.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTKMMSQFSVMDTEMLACVEGGGCNWGDFAKAGVGGAAVVAALG
                     CAAGGVKYGKILGPWGAAIGGIGGAVVCGYLAYTATS"
     misc_feature    complement(8911..8926)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 18.42"
                     /tool="antismash"
     gene            8934..9164
                     /gene="blpU"
                     /locus_tag="EQH27_RS02490"
                     /old_locus_tag="EQH27_02675"
     CDS             8934..9164
                     /codon_start=1
                     /gene="blpU"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093487.1"
                     /locus_tag="EQH27_RS02490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_02675"
                     /product="bacteriocin-like peptide BlpU"
                     /protein_id="WP_001093267.1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.9e-16,
                     bitscore: 57.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKMMSQFSVMDNEMLACVEGGGCNWGDFAKAGVGGGAARGLQL
                     GIKTRTWQGAATGAAGGAILGGVAYAATCWW"
     gene            9167..9286
                     /locus_tag="EQH27_RS02495"
                     /old_locus_tag="EQH27_02680"
     CDS             9167..9286
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000346296.1"
                     /locus_tag="EQH27_RS02495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_02680"
                     /product="PncF family bacteriocin immunity protein"
                     /protein_id="WP_001821949.1"
                     /transl_table=11
                     /translation="MDFKSFIIGLVVGIFGPYMDDLIRKKFLKSSKKDTDSTL"
     misc_feature    complement(9422..9435)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.08"
                     /tool="antismash"
     gene            9767..10125
                     /locus_tag="EQH27_RS02500"
                     /old_locus_tag="EQH27_02690"
                     /pseudo=""
     CDS             9767..10125
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000846948.1"
                     /locus_tag="EQH27_RS02500"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_02690"
                     /product="immunity protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MIFFVRLFLGQLPLLVSTYLFLFRQFSNFF"
     gene            10754..11137
                     /locus_tag="EQH27_RS02505"
                     /old_locus_tag="EQH27_02700"
     CDS             10754..11137
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398494.1"
                     /locus_tag="EQH27_RS02505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_02700"
                     /product="hypothetical protein"
                     /protein_id="WP_000877381.1"
                     /transl_table=11
                     /translation="MKYRLFFVIFLSSVLDILLGTFLQISIVSIGWLVLYSGLFEAGVF
                     LLANKGVAVKIKEVDIRNRFKFIFGKTLWFQILLLIFLIIKLYLGLDARLILFYGHIFI
                     VFNALMYLLSSSQVSLKKNKLSS"
     gene            11189..11878
                     /locus_tag="EQH27_RS02510"
                     /old_locus_tag="EQH27_02705"
     CDS             11189..11878
                     /EC_number="3.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000760553.1"
                     /locus_tag="EQH27_RS02510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_02705"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_000760513.1"
                     /sec_met_domain="Abi (E-value: 2.4e-10, bitscore: 37.7,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKYQLLFKISAVFSYLFFVFGLSQLTLIVQNYWQFSSQIGNFVW
                     IQNILNLLFIGVMIVVLVKTGHGYLFRIPRKKWLWYSILTVLVVVFQISFNVQTAKHVQ
                     STAEGWAVLIGYSGTNFAELGIYIALFFLVPLMEELIYRGLLQHAFFKHSRFGLDLLLP
                     SILFALPHFSSLPSLLDIFVFATVGIIFAGLTRYTKSIYPSYAVHVINNIVATFPFLLT
                     FLHRVLG"
     gene            11920..12153
                     /gene="blpZ"
                     /locus_tag="EQH27_RS02515"
                     /old_locus_tag="EQH27_02710"
     CDS             11920..12153
                     /codon_start=1
                     /gene="blpZ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000276505.1"
                     /locus_tag="EQH27_RS02515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_02710"
                     /product="immunity protein BlpZ"
                     /protein_id="WP_000276498.1"
                     /transl_table=11
                     /translation="MYKHLFFLDSKTLDRLTPYILVLASDTIAFNVFVLTFVSAVVFNF
                     LNSMLALMAIFIGAGYVVGFWLLILNENQRAN"
     gene            12304..12914
                     /locus_tag="EQH27_RS02520"
                     /old_locus_tag="EQH27_02720"
                     /pseudo=""
     CDS             12304..12914
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000394041.1"
                     /locus_tag="EQH27_RS02520"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_02720"
                     /product="lysostaphin resistance A-like protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MEFFDKFHALCLDF"
     gene            13075..13869
                     /gene="ccrZ"
                     /locus_tag="EQH27_RS02525"
                     /old_locus_tag="EQH27_02725"
     CDS             13075..13869
                     /EC_number="2.7.1.15"
                     /EC_number="2.7.1.229"
                     /GO_function="GO:0004747 - ribokinase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016773 - phosphotransferase activity,
                     alcohol group as acceptor [Evidence IEA]"
                     /GO_function="GO:0019200 - carbohydrate kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /GO_process="GO:0051726 - regulation of cell cycle
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ccrZ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000363010.1"
                     /locus_tag="EQH27_RS02525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EQH27_02725"
                     /product="cell cycle regulator CcrZ"
                     /protein_id="WP_000363002.1"
                     /sec_met_domain="APH (E-value: 4.3e-18, bitscore: 63.1,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLGDNELTLTPIPGKSGKAYMGSYPDGKRIFVKMNTSPILPGLA
                     REQIAPQLLWSRRLADGRDMCAQEWLTGKILTPYDMNRKQIVNILTRLHRSRPLMTQLS
                     RLGYAMETPVDLLQSWQETAPDALRKNHFISEVMADLRQTIPGFREDHATIVHGDVRHS
                     NWIETDSGLIYLVDWDSVRLTDRMFDVAHMLCHYISEHQWKEWLTYYGYKYNQTVLSKL
                     YWYGQLSYLSQISKYYMNQDLENVNREIHGLRHFRDKYGKRR"
     misc_feature    complement(14032..14046)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: weak, score: 17.11"
                     /tool="antismash"
ORIGIN
        1 ttactttaaa tcaaaatttg cccaattcca atatcctttc aaagaggttt actatctcga
       61 aacatcccca agaccccatc gtgttattct ctataccaag acggacaggc tagaatttac
      121 ggcgagttta gaggaggttt ttaagcagga accccgtctc ttgcagtgcc atcgctcttt
      181 tctcatcaat cctgcaaatg tggtgcattt ggataagaaa gaaaaactcc ttttctttcc
      241 caatggtgga agctgtctga tcgcgcgtta taaggtcagg gaagtgtctg aggctattaa
      301 taacttacac tgaactagga aatttatgta tattttttgg attatattgt atacacttat
      361 tactaatggg ctagaaattg tcattttctt taaggtagat ggaattggtc tcacttttga
      421 gaggattttt aaggcctttc ttttgaagat actgttggcc tttgtttttg taatgattgg
      481 ctatatggta ggaaatgttt acctatctta ttttatggaa cccttgtacg gcataggctt
      541 gtctttctta ttgttaagag ggcttcctaa aaaactcctt ttcttttatg gtctctttcc
      601 aatgatattg gtgaatctct tttatagagg agtctcctat tttgtgcttc catttttggg
      661 acaagagcaa gtatatgatg gctactcatt tactgggtta tgtataataa ttttcaattt
      721 cttcatttct ctagcctttt tgaaatggtt ggactatgat tttactagtt tgagaaggga
      781 gattctagat acaggttttc aaaagtccct gactaagatt aactggataa tgggggctta
      841 ctatttggtg atacaaagtc tgtcttactt tgaatatgag caaggtattc aatcaacgac
      901 tgttcgccat ctcatcctag tgttttacct cctatttttt atgggggtta tcaagaaatt
      961 ggatacctat ttgaaggaca aactccatga tagactggac caagagcagg tcttgcgcta
     1021 tagagatatg gaacgctata gtcggcatat agaggaactt tacaaggaag taaggagttt
     1081 tcgccatgac tacaccaacc tcttgacaag tttacgtctg ggtattgaag aggaggatat
     1141 ggagcagata aaagaggtct atgacttggt cttaaaggat tctagtaaaa aattgcagga
     1201 caataaatat gaccttggcc gattggtgaa tgttcgggat cgtgccctca aaagtctcct
     1261 agctggaaaa tttataaaag ctagagaaaa ggacattgtc tttaatgtcg aagttcctga
     1321 agagattcag gttgagggga tgagactgct tgattttcta accattgtgt ctatcctttg
     1381 tgataatgct attgaagcga gtgcagaggc cggtcaacct catgtttcaa ttgccttttt
     1441 aaaaagtgga gcacaggaga ccttcatcat cgaaaattcc atcaaagaag agggcataga
     1501 tatttctgaa atcttctcct ttggagttag ttctaaaggg gaggagagag gtgtcggtct
     1561 ctataccgtt atgaagattg tggaaagtta tcccaatgcc agtttaaata ctacctgtca
     1621 agatcaagtc tttcgtcagg tgcttactat gatacctaca gaatgataaa aaaataagac
     1681 cgagagttct tgttactcgg tcttattttt tatagttgta ttggatgatg aagtcctttc
     1741 gtattgttat gcttaattat attaaggctg tataagatat cttcccacag tcctccacct
     1801 gtaatttggt tgagttcggt agttgttagt tcttgaaatg aagttaagtt ttgtttctta
     1861 tccatgttat gattctcctt tttgataaga taataaatcc ccaattattc accccaaatc
     1921 taaaaaccat ccagaatcct tgccttagct tagatcctgg atggtttctt ttttcaccca
     1981 atgggtgttt tttactagac aaaaaagagt ttccccttta tggaataagt gtagaaaaaa
     2041 cacaaaaaga aaggaaactc acatgaacag tttaccaaat catcacttcc aaaacaagtc
     2101 tttttatcaa ctatctttcg atggaggtca tttaacccag tatggtggtc ttatcttttt
     2161 tcaggaactt ttttcccagt tgaaactaaa agagcggatt tctaagtatt tagtaacgaa
     2221 tgaccaacgc cgctactgtc gttattcgga ttcagatatc cttgtccagt tcctctttca
     2281 actgttaaca ggctatggaa cggactatgc ttgtaaagaa ttgtcagctg atgcctactt
     2341 tccaaaattg ttggaaggag ggcagcttgc ttcacagcca accttatccc gttttctttc
     2401 cagaactgac gaggaaacag tccatagttt gcgatgcctc aaccttgaat tggtcgaatt
     2461 ctttttacag tttcaccagc taaaccaact cattgtagat atcgattcta cccatttcac
     2521 aacttatggc aagcaagaag gtgttgctta taacgcccac tatcgtgctc atggctatca
     2581 tcctctttat gctttcgagg ggaagacagg ttattgtttc aatgcccagc ttcgtcctgg
     2641 taatcgttat tgttctgaag aggcagacag ctttatcaca cctgttttag aacggtttaa
     2701 tcaacttctc tttcgaatgg atagtggctt tgcgacccca aaattatacg atttaattga
     2761 aaaaacaggg caatactacc tcataaaact caagaaaaat actgttctga gccgtcttgg
     2821 agacctttcc ctcccttgcc cacaggatga ggacttaacc atcttgcccc actccgccta
     2881 ctcagaaact ctctatcaag caggatcttg gtcgcacaag cgtcgtgtct gccagttctc
     2941 tgaacgaaaa gaaggaaact tgttctacga tgttatttct ctcgttacaa atatgacgag
     3001 tggaacaagc caagaccagt ttcagcttta tcgtggacgt ggtcaagccg agaatttcat
     3061 caaggagatg aaggagggat tttttggcga taaaacggat agttcaacct taatcaaaaa
     3121 cgaggttcgt atgatgatga gctgtatcgc ctacaatctc tatctttttc tcaaacatct
     3181 agctggaggt gacttccaaa ctttaacaat caaacgcttc cgccatcttt ttcttcacgt
     3241 ggtaggaaaa tgtgttcgaa caggacgcaa gcagctcctc aaattgtcta gtctctatgc
     3301 ctattccgaa ttgttttcag cactttattc taggattaga aaagtcaacc tgaatcttcc
     3361 tgttccttat gaaccacctg gaagaaaagc gtcgttaatg atgcattaaa gaacagtcga
     3421 gatgaaaaaa tcgtgtgacg caccaaggga ggagtctgcc cttttgagga aatctagcga
     3481 ggaaaaacga tactggaaca gcagaaagta aaactgacct catgaggagg aagaaagtgg
     3541 ctcatgaggt caggggtttt gtaagttaca tctagttgag agaggtatga atgatttggg
     3601 taaatagtta tagagtgtta tctgaaaatt aatcagaatg ggttaaaatt ttatctttga
     3661 aataatcaaa atatgttttc tttgcagtta cactagtgac gcgaccttgt aagccatatt
     3721 ggatgagttt actatcctca ttagatagtt ttgcaagagc ggttaattta aagagattac
     3781 cttgctctgt tctggtagga gtttgatcaa ttgtctgaag ttggccgatg atggtggtgc
     3841 cgtgatttcc aatcttctcc agttttaatc ttacagtttg tcctttatct agtagaggta
     3901 gatagtcaga agctacgtag taagtgatta gtacttctct tgtatctgtg atgataggga
     3961 atatttgagc aatttctgta ccagttggaa ttctattttt accttcaaat tcgctgttca
     4021 gatgaacgat acctttactt ggagcggtta aggtattgtt tcctaagcgc tgcgttgctt
     4081 gatctagttg tacttttaat tctgttaatt gattctccac ggttagttgt tgctgtgagg
     4141 ctgtttgtaa aaactgagtg cggagtactt caattttggt tgctaaacta ttatcataag
     4201 ttgctacact tccgatacca gcttgctgaa ttttgaggct tgcgatagat gattcaagac
     4261 ctgcaatact ttgattaatt tgagataaaa atggctcctc tgccgttcct tgtgtttgtt
     4321 cttgagagac tataagataa cgatttaaaa ttgactggtg cggattgcca gttggtaagc
     4381 gagctctgtt atttatgata gcatctctca gctcttgata ttctccaatt tgttgttgaa
     4441 cttttgtaat ttcttgttcg atggctgatg aactgctatt ggcaagattg gcttgatttg
     4501 aaacttcagt gttagtcttt gagataccga gttcaatatc atgggattgt ttagtaaaat
     4561 tcataaaggt attatggtag ccaaactcat cctcgccaga aaaaagatca gtcgcttttt
     4621 ctaagctttg tttcaaaatt ccaagtcctt ctttttgctt ctcaagtctt tgtaattgag
     4681 ttgctaaggc agttttctga ctctcttcca ttgtttcaga gtatttgatg agtaagtcac
     4741 ctttctcaac tacttgattt gccactaaat gattagctag gataggatta tcactggtcg
     4801 actgaataga tgcaatgaca cttgtagggg tgatttctcc ttgcgatgta acagtaattt
     4861 cttttgtggc aacaagggag aaaatcaaga tgaaagtaaa cagtaatgac agaggtatga
     4921 ttaatactgt cgcatagtta tggtaacgtc tctgataaaa ctcgacactt ctaaaaagat
     4981 taggattcat gacattctcc ttatttattg aatagatgat ggtagaatcc ttgcgcttgc
     5041 attaactctt ggtgactacc aacttcaatg attttcccct ggtcaagaac aatgacacgg
     5101 ttagttcgtt cggctatact gagacgatgg gctacaaaga gaatggtttt atcagttagg
     5161 gatataagat tatctataac ctttttctca gtcaagacat caagaccgct agtagcttca
     5221 tctagtatta aaacaggagc tttagttaaa agagcacgag cgagagcgat tcgttgcttt
     5281 tgtcctcctg atagaccagc tccatcagag agctgagttt gatagcccat aggcattctt
     5341 tcaatgtctt gacgaatttc agctacttca caagctttta gaatatcttc ttgactaatc
     5401 atatgattac cgcccaaggt taagttttcc aaaatagagc cattaaagat ataggcttgt
     5461 tgtggtaggt aattaatatg acggcgcaag acttttttat caatgttttt aatatcctga
     5521 tgattgatgg aaatatgccc tttgtagggt tcaaagaaat tgacaatcat tttggctaaa
     5581 gttgttttac cagaaccact aactccaact aggctaacct tatctccttg tttaatcgtg
     5641 agattaatat ctgttaaggt atctcgtcca aaaccatact tataagaaag gtcatcaaat
     5701 tcaatatcgc ccatcaaaaa atgtgaatga acagggtttt cttgaacttg aaattcagat
     5761 tcgactagat agacttcgtt caaacggtta ttagcgacct tcgcagattg gagtttggtt
     5821 tggaggttga taatattttc cataggagtt gtaaagtaag aaaaaagtgt gttaaaggta
     5881 atcagctgac cgatagaaat tttacttgac atgactaatt gagcgccaaa ccataggata
     5941 aggatattca gaactaattt tgttccctgc tttaaactcg tttgtaaaat agaatattta
     6001 ctgagcttaa aggatttttc caaataatct acaaattcgc tgtctatatt ttgatagcga
     6061 ttttcttcac tcgtgagcga ctttatagtt tcaatcccgt tgatatcttc gataatggca
     6121 gagctaacca tagaattact ttgcatgaca tcatggttca ttttttcaaa aggtttcata
     6181 aaagaaaaga tgatgaacat gtatatagga atagaaataa gagaaagaag gaagagatta
     6241 gggttttgtg ccagtaagac gcctcctaca agaatcagaa tagaaacatc cagaaaaaga
     6301 gaaagaatgg tagaagccaa ggcatctata atagagttag catctgtgaa ccgtgaaatg
     6361 atttctcctg tacgacgtgt cgcaaagaaa gacatgggaa gttcaaaaat atggcgaata
     6421 taggataaaa tcacatcaat gcttaatctc tggctcagaa cggttaggag ataatctctg
     6481 gagaagctca tgacttgttg gaggatatag gtgataacca gaccaactga gatgattcct
     6541 aaagttgatt tcatctgatt tggaatgtat tcatccaaga ttccttggag atagtaagaa
     6601 ccacctatat tgataatagt gaccaataag cttgagagaa caatgtaagc aatgagagat
     6661 ttttgtttga aaatcagagg aaggaagctt gcttagtaga ccattctttt tatctttatg
     6721 gggttgatag ctgggtttgg tagctagaaa aatagctact ccagtccatt catagaaaaa
     6781 gcgttctttt gacattttag tgatttttac agaagggtca ggatcaccaa taatcagata
     6841 gtctttcttt gtttgataga caacatagta atgttggagt tttccttctt tgttaacgtg
     6901 aacgataaat ggatagggga catcactcat gtcaaagagc gttttatctg cttgaacagg
     6961 tcttgtttca aagcccattt catcagcggc ttttacaatg ccaagagcag tcgtcccttc
     7021 tttattggtc tttgcaagtt ctctcaagtg agctagagaa aaatctgaac catagaattt
     7081 agcaatcgag gctaaggcag cgacaccaca gtctctcgca tctatttgag gaacaaatgt
     7141 acgtttataa gaagtcattg gcaattcttt tcatatagtg gataggtcta ttatgtcata
     7201 aaactaagtt catattttat gaaatcttga atagtcatta aaacttcctg aatggtaaaa
     7261 aagtgattag aaattatttt ttttaaacat ttagaggtgg cttgaaataa aaaagctaat
     7321 tcaagacgtt tcgatgacaa ttcaagatct ggatgaaaaa ttttaaaaaa cgatgatata
     7381 ctaaacttat caaagttaca acaagacaaa aataaaaaaa gaaaaaagga gtatttgtca
     7441 tgaatacaaa aatgatggaa caattttctg ttatggataa tgaagaactc gaaatagtta
     7501 gtggaggaag aggcaattta ggatctgcaa tcggtggttg tattggagca gtactattag
     7561 ctgctgcgac tggtccgata actgggggag cagcaacact tatttgtgta ggttcaggaa
     7621 ttatgtcctc tttgtaagat tatgattctt aaatatagta ttattatcgc tattaattta
     7681 ctgtcttatt tacttactta caaaatatca aagttatcta agaatgatga gaataagata
     7741 gttagcaaaa ttttaattat attatcaatc gtttatgtaa tcgttgatgc tttacttagt
     7801 tgatggattg gtaggaataa aaaacttaac tataaactat tatttactaa tattttttgc
     7861 tttctgcaag ttaataaata gtatagtaaa actttttatt gcaaggagaa taacgaaatt
     7921 aagatatttt agatactcaa gattattgaa atcttagact aaaaaatagg tactgctacc
     7981 tttaagaaga tagtagacgt atatactttt ttaagaaaat caaaaagata ctataaaaaa
     8041 tctatttgtt tattgaattt aagactttgg taacaaattg aaaataaaaa ggaggtattc
     8101 atcatgaata caaaaatgtt gtcacagtta gaggttatgg atactgaaat gcttgcgaaa
     8161 gttgaagggg ggtatagctc cactgattgt caaaatgcac tgattacagg agtcactacg
     8221 ggaattataa ctggtggaac tggagcaggt ttggccactt taggagtagc tggacttgct
     8281 ggtgcatttg ttggagcaca cattggtgca attgggggtg gattaacatg cttaggaggt
     8341 atggttggtg ataaattggg actaagttgg taagacttat agtaaaatta tgaggattct
     8401 attctgattt attttagttt tttaaaaaag gagtatttgt catggataca aaaatgatgt
     8461 cacaattttc tgttatggat accgaaatgc ttgcttgcgt tgaaggtggc ggatgcaatt
     8521 ggggagattt tgccaaagca ggtgttggag gagcagctgt agttgctgct ttaggttgtg
     8581 cagcgggtgg agtgaaatat gggaaaattc taggaccatg gggcgctgca ataggaggaa
     8641 ttggaggagc agtggtttgt ggatatttag cctataccgc tacatcataa aaatgaaagc
     8701 taaattttat gaaggctata ttctttatta ttctcttcgc ttttcaaacc tatcttattt
     8761 atctatccat aagtatctct gataaaaaac aaaagactat tgaattaaca tcattgaatt
     8821 gttttgtcat attatttcta atctatgata aattaatttt tctctttatt gcctatgttt
     8881 ttttgataat ttttatatta aacttgttcc gtaactgaaa agtgacatac tatatgaata
     8941 caaaaatgat gtcacaattt tctgttatgg ataatgaaat gcttgcttgc gttgaaggtg
     9001 gcggatgcaa ttggggagat tttgccaaag caggtgttgg aggaggagca gcacgaggtc
     9061 ttcagctagg aattaaaaca agaacatggc aaggtgcagc aactggtgct gcgggaggag
     9121 ctatacttgg aggtgtggcc tatgcagcga catgttggtg gtaattatgg attttaaaag
     9181 ttttattatt ggtttagtag ttggtatatt tggtccttat atggatgatt taattagaaa
     9241 aaaattttta aagtcttcca aaaaggatac ggatagtact ctctaaaaaa taaatttctc
     9301 ccctgtattt gctagcttaa tttacagggg agtttcttta atattgtttc gcctgtcaaa
     9361 atgatatgtg atagcaggat gaaaagtcta caaacaagtt ggtatcaata caatataaag
     9421 aggaaagtat gtttttcatg cttgcttttt taatttttac aattcaagag gttttgatga
     9481 ccatttatga tttgagtgat ccaaggtcaa aataagtgct atactagcag tgtaaatgtt
     9541 cttgctcaac taagataaat cgcacattta ggaggaaaac ttatgaagaa aaaaatactg
     9601 attattttcg ttctgtatct gatcatgtcc atctttcttt atccgcttag ggagagtatt
     9661 tggtataatc tattttatac catagcctat atgattgcgg ttatgatcta tttttcttta
     9721 attaaaaaga aagaaaagaa atgaaagatt ttcttgatta aaaagaatca tattctttgt
     9781 gagattgttc ctgggtcagt tgcctttgct tgtttctact tatctatttc tatttcgtca
     9841 gttttccaat ttcttttagt agttattaac ttgacttcta ttttggttac tgtttatctt
     9901 actagggaaa tgagattaag agagtttgaa gatgatgatt tggttagtcc tagaaccaat
     9961 caactcatgt ttatcggctt gacaggcttt atgtctatta tttgtttgta tagaggtatc
    10021 acagcaggag aatcttatca acaactaatc gcttatattg gtgctattct ttgcttgatc
    10081 atcatgcttc tacttatttg gggtttgaag tattataaaa agtaggggct aatgaagttt
    10141 ttgcaattta ggaggtttcg atgacaattc aagatttgga tgaaaaattt taaaaaacaa
    10201 tgatatacta aacttgtcaa agttgcaacg ggtgctgcta cattatgtta aaaatcgctc
    10261 ttgattgata agttggattt gttaggaaag gagtaaataa ttatggataa gaaaaagata
    10321 gtttcgacta taatatgtat agtatttctt gtagtgtcag tagataattt ttttagagac
    10381 ttaaccccgt tattgttcat tttaaatatt attggcctaa cttgtttttt agtgttaaca
    10441 tacactaaca taaaagagat actcttaaat ataagtaaat gatgatttgg ttagtcctag
    10501 aaccaatcaa cttatgttta tcggcttggc agattttatg tttgtcattt gtttgtatag
    10561 aggtatttca gaaacagaat tctatcaaca actaatcgtt tatataggtg tattctctgc
    10621 ttgtttatca cgcttctgct catgtggggc ttgaagtatt ataaaaagta gctttctatc
    10681 cttttctgac aggatatttg agtagaaggc tctattaaat tgttagtgaa ataaatgaat
    10741 ggaggtattt aatatgaaat acagattatt ttttgttatt ttcttgagta gtgtgttgga
    10801 tattctttta gggacatttt tacaaatctc tatcgtatct attgggtggc ttgttcttta
    10861 cagtggtttg tttgaagcag gagttttcct tcttgctaat aaaggggtgg cggtaaaaat
    10921 caaggaagta gatattcgaa atcgctttaa atttattttt ggaaaaacct tatggtttca
    10981 aattcttttg ctcatctttt tgataatcaa actttatctt ggtttggatg cgaggttgat
    11041 tttattctat ggacatattt tcattgtctt taatgcctta atgtatctat tatctagtag
    11101 tcaggttagt cttaaaaaaa acaaactgtc ttcttaatct tacagcagta gagcctgaca
    11161 aggtgaggtc atagtaggga ggatttctat gaaaaagtat caacttctat tcaaaataag
    11221 tgcagtcttc tcttacttat ttttcgtatt tggtctttct cagctgacgc ttatcgtcca
    11281 aaattattgg caattttctt cccagattgg taatttcgtc tggattcaaa atatcttgaa
    11341 tttacttttt attggagtca tgattgtggt tcttgttaag acaggccatg gttatctctt
    11401 ccgcattcca agaaaaaaat ggctttggta ttcgattttg acagtattag tggtagtgtt
    11461 ccagatctct tttaacgttc agacagctaa acatgttcag tcaactgcgg aaggttgggc
    11521 tgtattgatt ggttatagtg ggactaactt tgcagagcta ggtatttata tagccctgtt
    11581 ctttctggtt ccactgatgg aagagttaat ctatagagga ttactgcaac atgctttctt
    11641 taagcattcg cgatttggtc ttgatttgct tcttccttct attttatttg ctctccctca
    11701 tttttcaagc ctgcctagtc tgttagatat cttcgtcttt gcaacagttg gaatcatctt
    11761 tgctggtttg acccgctata ccaagagcat ttatccatcc tatgcggtgc atgtgatcaa
    11821 taatattgta gcgaccttcc cgtttttgct cacttttcta catagggtct tggggtaaaa
    11881 aaacaaaagg cttgcttttc agccatagag gaggtcatca tgtataaaca cttatttttc
    11941 ctagattcca aaactttaga tcggttgaca ccctatattc tagtcttggc ttctgacacc
    12001 attgctttta atgtttttgt gctaaccttt gtatctgcgg tggtttttaa tttcctaaat
    12061 tccatgctag ctttaatggc tatattcata ggggctggct atgtggtcgg attttggtta
    12121 ctaatactca atgaaaatca aagagcaaac taggaaacta gccgcaggct gtacttgagt
    12181 acggcaaggc gacgttgacg tggtttgaat ttgattttcg aagagtataa aatggtttgt
    12241 tttggaaagg ctagaactaa agaatgacgt gtaggaagtc tgtttgttga ggaggataat
    12301 tttatggagt tttttgataa atttcatgcc ttgtgtttgg atttttagta ctaataattg
    12361 tcattatagt tccttatacg attaaccatg gggatttttt tcaaaatgaa tctgcattga
    12421 ttcttgtaag tcttcttgta acctcgctga gtgttgctta tgctagaaag tttgaaatga
    12481 tttcttttgg gatgttaagc aagaaacaac ttttgctttt cattgcaatc tttcttctaa
    12541 gtgtacttga gacgctggtt tatattcatt tcttcgctgt ttcttctggc tcaggggtcc
    12601 aacacttggc ggaagtcagc agaggaattt ccctgtcttt gattttgact acctcagttt
    12661 ttggccccat ccaggaggaa ctcattttca gaggacttct tcaaggtgcg gtttttgaca
    12721 attcttggtt agggcttgtg ctaacttcct ctctcttttc tttcatgcat ggaccttcta
    12781 atgtcccttc gtttattttt tatctacttg ggggcttgtt gctgggcctt gcttataaaa
    12841 agagccaaaa cctatgggtt tctactctag tccacatgtt ttacaacagt tggccactcc
    12901 tatattattt ataaaaatta tgaaaaggta agcagaagac ggtgcttacc tttttcaagc
    12961 tataatgata cccaagccaa tccagaggct tttctttgag aatcgggtta gagtggttga
    13021 cgaataggcc aaaaactagt agaatagtaa ggaaacttta tacggaggaa agaaatggat
    13081 ttgggtgata atgagctaac actgactccc atacctggga aaagtggcaa ggcttatatg
    13141 ggtagctatc ctgatgggaa gcgcatcttt gtaaaaatga acacctctcc aatcctacct
    13201 ggtctagcta gagaacaaat tgctccacaa ttattatgga gtcgtcgttt ggcagatggg
    13261 cgtgatatgt gtgctcaaga atggttgaca ggcaagatat tgacccccta tgatatgaat
    13321 cgtaagcaaa tcgtcaatat tttaacccgt cttcatcgct cacgtccgtt gatgacacaa
    13381 ttgagtcgtt tgggctatgc catggaaaca cctgtagatt tactacagtc ttggcaagaa
    13441 acggctccag atgctttgcg taaaaatcat tttatcagtg aagtgatggc tgatttgcgt
    13501 cagactattc caggatttag agaggaccat gcgaccattg tccatggaga tgtacgacat
    13561 agtaattgga ttgagacaga tagtggcttg atttatttag tagattggga ttcggttcgc
    13621 ttgaccgatc gcatgtttga tgtggcccat atgctctgcc attatatttc agaacatcag
    13681 tggaaggaat ggttgaccta ctacggttac aagtacaatc aaacggtatt aagtaaattg
    13741 tattggtatg gtcaattgtc ttatttgagt cagatttcca agtattatat gaaccaagat
    13801 ttagaaaatg tcaatcggga gattcatggt ttgcgtcatt tccgagacaa gtatggaaag
    13861 agaagatgag agttagaaat cgtaaagggg caacagaatt actagaggca aatccccagt
    13921 atgtggtcct caatcccttg gaagccaagg caaaatggcg ggacttgttt ggcaatgata
    13981 atcccattca tgtggaagtt ggaagtggaa agggtgcctt tgtttcaggt atggccaagc
    14041 aaaaccctga catcaactat atcgggattg atattcaaaa gtctgttttg agctacgctt
    14101 tggacaaggt gcttgaagtt ggagtgccta acatcaagct cttgtgggta gatggttctg
    14161 actt
//
