LOCUS       NZ_CP091381            21023 bp    DNA     circular CON 18-AUG-2024
DEFINITION  Amycolatopsis sp. FU40 chromosome, complete genome.
ACCESSION   NZ_CP091381
VERSION     NZ_CP091381.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. FU40
  ORGANISM  Amycolatopsis sp. FU40
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 9944196)
  AUTHORS   Reisman,B.J. and Bachmann,B.O.
  TITLE     Biosynthesis of Apoptolidin Family Glycomacrolides
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9944196)
  AUTHORS   Reisman,B.J. and Bachmann,B.O.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-2022) Chemistry, Vanderbilt University, 1234
            Stevenson Center Drive; Room 7330, Nashville, TN 37235, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 23-JAN-2022
            Assembly Method                   :: Flye v. 2.9
            Assembly Name                     :: NFU40_flye_2.9
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 47.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_021903635.1-RS_2024_08_18
            Annotation Date                   :: 08/18/2024 04:30:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,491
            CDSs (total)                      :: 9,417
            Genes (coding)                    :: 9,360
            CDSs (with protein)               :: 9,360
            Genes (RNA)                       :: 74
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 7 of 57
            Pseudo Genes (incomplete)         :: 50 of 57
            Pseudo Genes (internal stop)      :: 5 of 57
            Pseudo Genes (multiple problems)  :: 5 of 57
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:13:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 9241407
            Orig. end                         :: 9262430
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP091381.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Brian O. Bachmann,
            Vanderbilt University.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21023
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="39"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21023
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21023
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11023](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11023)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    451..462
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.34"
                     /tool="antismash"
     gene            591..2315
                     /locus_tag="L3Q65_RS43835"
                     /old_locus_tag="L3Q65_43830"
     CDS             591..2315
                     /NRPS_PKS="Domain: Aminotran_5 (86-336). E-value: 1.5e-27.
                     Score: 88.4. Matches aSDomain:
                     nrpspksdomains_L3Q65_RS43835_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013223402.1"
                     /locus_tag="L3Q65_RS43835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_43830"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_182892364.1"
                     /sec_met_domain="Aminotran_5 (E-value: 4e-22, bitscore:
                     77.7, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRIPPRYLLQFDEPAGYLDFARFGPPSHAVLDTTARLLEATTKA
                     GPSTVDELMRQEIRAKAAAARLCGSDTDHTVLLPHTSLGLFQAAFNSHGEVLVSAAEFP
                     ANTYPWARAEQAGRVRMRRLEGGYVTADRLAEALTPETAVVSVSAVDFRTGYRADLAAL
                     REVAGDRLLVVDGIQGFGVVDAPWEVADVLVVGGQKWLRAGWGTGFAVLSDRALARMDP
                     ILSGWTGARDPGLFDNEIHPADPTAASWSISNLSPVTSGAFAAALELVEETGVAAIAGR
                     IDERVGELEEVLRSFGAEIVSATERRAGILAFSLPDKPAEQVGAALTAAGIAATVRPEH
                     VRLSPHASTPAAAAEQVRDALETLLRPRRVVPVASAAGTATHELLTALIPAVDGLAAML
                     GPGNEVLLHDLSRLPDSIVAIAGKLTGRSVGGPMTDLLLGLVRRGTTQDLTNYRTHSPD
                     GREIRSSTLFLRDAEGTAIGCLCVNSELPAAAQTSEERREETFLPDVDSLQRFLVGRAI
                     GKSGIPVELMKKRHKSAVVRELDEAGYFLIKDAVDHLAAQLEVTRYTIYNYLNEIRA"
     misc_feature    684..686
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        849..1598
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_L3Q65_RS43835_Aminotran_5.1"
                     /evalue="1.50E-27"
                     /label="L3Q65_RS43835_Aminotran_5.1"
                     /locus_tag="L3Q65_RS43835"
                     /protein_end="336"
                     /protein_start="86"
                     /score="88.4"
                     /tool="antismash"
                     /translation="QAAFNSHGEVLVSAAEFPANTYPWARAEQAGRVRMRRLEGGYVTA
                     DRLAEALTPETAVVSVSAVDFRTGYRADLAALREVAGDRLLVVDGIQGFGVVDAPWEVA
                     DVLVVGGQKWLRAGWGTGFAVLSDRALARMDPILSGWTGARDPGLFDNEIHPADPTAAS
                     WSISNLSPVTSGAFAAALELVEETGVAAIAGRIDERVGELEEVLRSFGAEIVSATERRA
                     GILAFSLPDKPAEQVGAALTAAGIAATV"
     gene            2315..3202
                     /locus_tag="L3Q65_RS43840"
                     /old_locus_tag="L3Q65_43835"
     CDS             2315..3202
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF016533.4"
                     /locus_tag="L3Q65_RS43840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_43835"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_237598271.1"
                     /sec_met_domain="APH (E-value: 3e-06, bitscore: 26.4,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVVVPARLAKAVRRREGAAAEAWLRELPGLVEDACVRWDCQIAG
                     SPLHGETALVLPVECAGQAAALKISFPHQHCAAEAAALKHFDGAGVVRLLEASADSSTL
                     LLERVGPATLETVRVEEATEIAGELARRLAVPAPAGTRALSSTTGPWLAQLDQQAMPGL
                     LPKREVDRARELIAFLADDRTGTMLHGDLHFGNVLRARREPWLAIDPIGWRGTAAFDAF
                     TVVARRRRADDLTALITRFSRAAQTDPGLAARCCQARAVSAYLHQEHTGGAWFDRDVLL
                     ALISGTSPPRPRPR"
     gene            complement(3162..4328)
                     /locus_tag="L3Q65_RS43845"
                     /old_locus_tag="L3Q65_43840"
     CDS             complement(3162..4328)
                     /GO_function="GO:0016758 - hexosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020662016.1"
                     /locus_tag="L3Q65_RS43845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_43840"
                     /product="macrolide family glycosyltransferase"
                     /protein_id="WP_182892362.1"
                     /sec_met_domain="MGT (E-value: 1.1e-40, bitscore: 139.2,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKHIVVVGCSAPSHIYPSLGIVRELVRRGHRVSYVVGEPLAELV
                     GATGADVVAHPTIFPLGPDAEWPEDPAEAMRVFLDEAIAIHPRLIETFDQDRPDLLLYD
                     IGGLGAPLLGLRYDVPAVQLSPAYVAWDGYEEELADVLDPIRTSPSGVDYDRAFTEWLA
                     ENGVTEDAWTWLARPVPILSLIPRAMQPNADRVPEDRVQFVGPCLDPARAAEHWTPPSD
                     GKPVLLVSFGTAYNDQLDVYRHCITEFEDWHVVLSIGKHVSKDDLGPLPKSVEVHETVP
                     QLAILDVASAFITHAGMGGCTESLWYGVPTVAIPQAVDQFGNAAQLEALGVGKHLPADQ
                     VTAKSLREAVDEVSSSSDVAARLAELRSEIRANGGITAAADAVEKFLK"
     misc_feature    4551..4564
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 17.21"
                     /tool="antismash"
     misc_feature    complement(4570..4583)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.84"
                     /tool="antismash"
     misc_feature    complement(4571..4584)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.49"
                     /tool="antismash"
     gene            4613..5515
                     /locus_tag="L3Q65_RS43850"
                     /old_locus_tag="L3Q65_43845"
     CDS             4613..5515
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020662015.1"
                     /locus_tag="L3Q65_RS43850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_43845"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_182892361.1"
                     /transl_table=11
                     /translation="MTEAFRLTGLVKQFKQVRAVDGVSMTVRRGEVVALLGPNGAGKST
                     TIDMLLGLASPDEGSVRVFGGAPRAALDSGRLAAMVQNGFLLRDVTPAELVELHRSMFE
                     NPLPAKEVYARAGIGEFAKRRCGKLSGGQLQRVRYALALTGDPELLILDEPTAALDVDA
                     RREFWASMHEFTAAGRTVLFATHYLAEAEDYADRVVLMRHGKVVADGAVDEVRANVSGR
                     VIRAVVQGARPEALAALDGVASARVQGDRTELGCTDSDLAIRALLAAFPQASSIEITSA
                     GLEEAFLALTSDEPQGALR"
     gene            5512..6246
                     /locus_tag="L3Q65_RS43855"
                     /old_locus_tag="L3Q65_43850"
     CDS             5512..6246
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009073745.1"
                     /locus_tag="L3Q65_RS43855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_43850"
                     /product="ABC transporter permease"
                     /protein_id="WP_182892360.1"
                     /transl_table=11
                     /translation="MNLVYLRLEILRIVRSPQFALFTIVVPLGMFLLFGGLFGDQVGPD
                     GIKASVTTMINMGAYGAMSGALFTGTRVATERTDGWQRQLRLTPMRGPGYLAVKIASSM
                     AMALPVVLVIFVAGALRGVQLTPAQWLLSGLSLWLGALPFAVLGLLLGLFGKGDTVGAM
                     TGALMLPLGVFGGLWMPLSILPEWMSALAHFFPTYWLGRVGTLPVDHAGGLGLAVGVLA
                     AWLVVPALVVVRRFRLGPVKVA"
     gene            6301..6948
                     /locus_tag="L3Q65_RS43860"
                     /old_locus_tag="L3Q65_43855"
     CDS             6301..6948
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009073747.1"
                     /locus_tag="L3Q65_RS43860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_43855"
                     /product="hypothetical protein"
                     /protein_id="WP_237598272.1"
                     /transl_table=11
                     /translation="MNNDAGDPVEDEGEPLSVAESLELIARQNERTRRELRVSPARLFA
                     VWAFAWLVGWGLVYLSDGRSAALMPGWVAGIVVAVLMVGAIVYSAWHGSKGGRGIRGPS
                     QRIGAMYGWAWMISFAGMSLIDIRITKLLPEGSDLVPLLWSGTSLLLTGALYLAGGTLW
                     QDMRQYFLGGWIIVCSGASVLVGVPGNFLVLSLAGGGGFAVAALVYVVRPRD"
     gene            6941..7246
                     /locus_tag="L3Q65_RS43865"
                     /old_locus_tag="L3Q65_43860"
     CDS             6941..7246
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009073749.1"
                     /locus_tag="L3Q65_RS43865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_43860"
                     /product="transcriptional regulator"
                     /protein_id="WP_116205832.1"
                     /transl_table=11
                     /translation="MTELPELDPVIHAQARLRVTVALAGLRPADQITFPRLQQLLEMTA
                     GNLSTHLRKLEDAEYVEITKAYEHRTPVTLVRLTSKGRAAFESYTKALQRLLDAGT"
     gene            7248..8567
                     /locus_tag="L3Q65_RS43870"
                     /old_locus_tag="L3Q65_43865"
     CDS             7248..8567
                     /EC_number="2.7.7.7"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009073751.1"
                     /locus_tag="L3Q65_RS43870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_43865"
                     /product="DNA polymerase IV"
                     /protein_id="WP_237598273.1"
                     /transl_table=11
                     /translation="MSRWVVHLDLDAFYASAEQLTRPTLRGRAVVVGGTGHRGVVAGAS
                     YESREYGVRSAMPMSQARRLLPAGGVVLPPRFRLYEILSKQVFDVVGEVAPVLERISLD
                     EAFAEPPALAGASVEQVTGWAEELRARIRERTGLTASIGAGTGKQVAKIGSDRAKPDGL
                     LVVPPGTEREFLAPLPVRALWGIGPVAEAKLRTIGVLTLGELAALPEPDAVSTLGGVVG
                     RDLRRLASGFDDRPVAERGEAKQVSAETTFDVDVVDLVRLRAEVRKIAAGAHSRLVKAG
                     RVARTVVIKLRHTDMSTVTRSETTASPTDDLEQLAATAERLLLDPQEFGGVRLAGVAFS
                     GLSVPHQDALFSLTVPAATEEPVVTSAPSPGGSAPVSSSGWRPGDDVVHAEFGTGWVQG
                     AGHGRVTVRFETRTSGPGVARTFDQTDPALARGQPADCLA"
     gene            8647..9771
                     /locus_tag="L3Q65_RS43875"
                     /old_locus_tag="L3Q65_43870"
     CDS             8647..9771
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020662010.1"
                     /locus_tag="L3Q65_RS43875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_43870"
                     /product="CapA family protein"
                     /protein_id="WP_370648243.1"
                     /transl_table=11
                     /translation="MIMTNTRRAAALAGVALMLTACGSEAAPQRSSAGPASSSAAASPD
                     SFTVVATGDVLIHPRLTEQAEADGGGKIDYRQLFAGVKPLVSGADLGICHLETPLAPEG
                     GPYSGYPSFSAPPEIADALKDTGYDTCSTASNHTLDQGAAGVQRTLDKLDQTGLKHTGS
                     ARSAEEAGKPLILDVHGVKVAQLSYSFGFNGIKRPAGKPWLANEIDPDEILAAAREAKA
                     AGAEVVIASLHWGVEYQHDVTAEQKQLAQKLTASPDLDLIVGHHAHVVQPFQKVGGKWV
                     AFGLGNEVARHDEPRGSTEEGVAARFRFSRAGGKWTVDKAEYVPTLIDLGPPIRLRDLT
                     TAPPSERGKEALANTDEVVLSRGAGDDGLSRLGR"
     gene            complement(10001..11023)
                     /locus_tag="L3Q65_RS43880"
                     /old_locus_tag="L3Q65_43875"
     CDS             complement(10001..11023)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013223417.1"
                     /locus_tag="L3Q65_RS43880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_43875"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     polyprenyl transferase"
                     /protein_id="WP_237598274.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 3.9e-65, bitscore:
                     218.9, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTVDARTGARSVAEVLDWSRSRWEPAMRAAVDRLPVSMRRIAGY
                     HLGWWDETGTATSAAGGKALRPALVLLCAEACGGDPEDAIPAAVAVELAHNFSLLHDDV
                     MDGDRTRRHRPTAWTVFGTGQAVLAGDSLLALAFDVLSPDGPAAARLLSTAVLDLLHGQ
                     HEDLAFEQRTNVEVAECVRMAQGKTAALLSAACTLGVLVVGGRGEHVERFGRFGRSLGL
                     AFQHVDDLLGIWGDPAVTGKPVYSDLRSRKKSLPVVAALTSGTSAGQELAMLYRQPLPD
                     DCLAKAAALVDEAGGRSWSHAQADELLTDALAALTAANPAPRPTAELTAIAQLITRRDH
                     "
     gene            complement(11020..11310)
                     /locus_tag="L3Q65_RS43885"
                     /old_locus_tag="L3Q65_43880"
     CDS             complement(11020..11310)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="L3Q65_RS43885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="L3Q65_43880"
                     /product="hypothetical protein"
                     /protein_id="WP_182892355.1"
                     /transl_table=11
                     /translation="MTRLSLSTGQQHRQCPKRSFGKQVNRTRLPDRVIVEIIRLAMLMR
                     GAAYDFAFLSRKTPLRRVPAFSTLGGFAVIVPSPSALSTVAAVLRPEAEER"
     misc_feature    complement(11104..11106)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(11224..11226)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    11498..11512
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 20.47"
                     /tool="antismash"
     gene            11541..12302
                     /locus_tag="L3Q65_RS43890"
                     /old_locus_tag="L3Q65_43885"
     CDS             11541..12302
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009073760.1"
                     /locus_tag="L3Q65_RS43890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_43885"
                     /product="hypothetical protein"
                     /protein_id="WP_182892354.1"
                     /transl_table=11
                     /translation="MNVYVTGVFWVVGAAIAAAVIGYLVRRFGWDEGRRDNNDAAGQVF
                     TIVGGLHAVLVAFVLISLFDAVTATREGSYTEAEGLVAATWSAQALPGDTGEQVRRLAI
                     AYATTVSKQEWPRLVDDGPVPDTGWTQLDQMRRVVASAQASDDWTNDRKKDAAAQLWQV
                     YQARQTRLTGAETDGVGSVMWFALILGSVISILLPNLFGGTRMAAHLVIVSTLAGTIVL
                     LLYAIYQLQNPYAGGANVHPDAFTSAISRLG"
     gene            12306..13571
                     /locus_tag="L3Q65_RS43895"
                     /old_locus_tag="L3Q65_43890"
     CDS             12306..13571
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013223421.1"
                     /locus_tag="L3Q65_RS43895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_43890"
                     /product="hypothetical protein"
                     /protein_id="WP_237598275.1"
                     /transl_table=11
                     /translation="MRGSRYLTVVAAAAAVAGLLVASGWLAPARQRAAATSCRVLQVES
                     RDGQSSDIVRLTLPSGARHLLHHSPFALNAIAYSAAQDVTYGVADGRFHDGWHAVRIDS
                     GGELTDLGAVGRETHHGVWSWVTGATAGAMSGSSWYVKRATSLYTVDVDPHSSGYLTAT
                     GPVLLHPWWLASGVDDFAYNPEDALLYGVSSAAEGAVVTVNPVSGTVAKVPGEQFPAAT
                     YGAVVFGPDHKLYATANWIDGRSVTYRMDGGSAVEVSTGPPLVMSDGAGCLAEPPPPPP
                     PPPPPPSSSTPPTTSSSPTTTPSSPSPTPTPSSSASPTPSSTPVPPPHPSSPPSFPPPT
                     TPSPVTPTPTPQPPDAIIQPIPMPQPPAPSRAAPVKGIPKPPEKRTAKARDNVKKQRRW
                     GVAAVLLIVGGGAVAARARRAR"
     gene            13662..15227
                     /locus_tag="L3Q65_RS43900"
                     /old_locus_tag="L3Q65_43895"
     CDS             13662..15227
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020644039.1"
                     /locus_tag="L3Q65_RS43900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_43895"
                     /product="esterase-like activity of phytase family protein"
                     /protein_id="WP_237598276.1"
                     /transl_table=11
                     /translation="MKRVKIGLVAGALVLPLAAAGPAEAKGRPDDHYRVRAGHTLQVRG
                     DAQRDGAVVRHTDPGHGALAIGPDGSFRYTPAAGFTGRDTFTYTVSDAVRLYPTDLPPL
                     GTVGGVKITGGGYGSALTPVPGSRDEFYGLTDRGPNVDAPDGSKVEPLPSFTPAVGKFR
                     LKGGKAVLERNIPLRAADGSPYNGQVNTLANTGETIVDLNGAKLPASPNGYDSEGLVAQ
                     RDGTFWVSDEYGPFITHFRADGRAIERLSPFDGSLPKELKNRVPNKGMEGLALTPDGRT
                     LVGIMQSALQQPDLTKKPSKVPALRIVTVDLKTRATHEYAYLLDNPDETSTAVSEITAL
                     SATRFLVDERDGKAEPGAYKKLFEIDLSKATDLGPAAKVPGATYDAVKGGLLVDGGKSI
                     EAYVGKATTAEAADALAKVGVTPAAKKLFLDVGGLVTGLDPSGGFFGHDKVEGVATTDG
                     DRTVVISNDSDFGIDGVANSTAPYTLHAKAQPNGRQDDGEYLKVDMAKLPARTRTLTVT
                     VDVR"
     gene            complement(15234..16247)
                     /locus_tag="L3Q65_RS43905"
                     /old_locus_tag="L3Q65_43900"
     CDS             complement(15234..16247)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1205: ABC
                     transporter, carbohydrate uptake"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009073766.1"
                     /locus_tag="L3Q65_RS43905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_43900"
                     /product="autoinducer 2 ABC transporter substrate-binding
                     protein"
                     /protein_id="WP_182892351.1"
                     /transl_table=11
                     /translation="MRGRTKTLVLGAALVATAAALAGSCSPVLSGSAPEQAKIAFVPKI
                     GGIPYFDAMNAGGMLAAKRLGAKWFLRAPASVDPAAQTAILRQLIAERVDVIAVAPNDP
                     AELAPTIAEARAKGIHVLTTDTDAADSQREVFVNQTTAEGIGSALVDSLMKKTGGTGEY
                     AIVSCGRAAANLNSWIEAEKTYAAQRYPQAKLVETVYADEDTTTATKLAKEILNRHPKL
                     TGMIGQCTTATPGIARAVRDQQKIGQVFTVGTGTPQTMKPYLVDGSCSMTVLWNVESLG
                     YLTAWTAEQLATDAPLKPRNNVSPELPAVRYDAATRTVLLGDPLLITQNNVDQFKY"
     misc_feature    complement(16269..16279)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            complement(16346..17812)
                     /locus_tag="L3Q65_RS43910"
                     /old_locus_tag="L3Q65_43905"
     CDS             complement(16346..17812)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (82-451). E-value:
                     5.5e-25. Score: 80.3. Matches aSDomain:
                     nrpspksdomains_L3Q65_RS43910_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012770.4"
                     /locus_tag="L3Q65_RS43910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_43905"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_237598277.1"
                     /sec_met_domain="PF00561 (E-value: 1.7e-29, bitscore:
                     102.3, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVINSARRRAAAFVLVLLPGSLLSAPAASARTSSLKWGACPAGTP
                     RQVSCASLRVPLDYAKPNGKQITLTVSGMGSLSAPHFLLVNPGGPGASGLGTEKLVFSQ
                     LPRDVAQQYAAFSFDPRGIGASTPVSCGDTSELAPHPASPYQPADLPQERKREGFAKQI
                     AARCAANGKDLLPQVTTENAARDMDRIRQALGKDKIDYLGYSYGTKLGATYATLFPAHT
                     GRMILDSVVDPTATTYQTQFQQNAALQARAEQLFAWTAERDSTYHLGATASAVKTAWNE
                     LREKLAARPADGKTGVSELDDLLASAMYGDWAWPSLMQAIASHRGGDSAGLNVAAGQAR
                     YAVDPGQLAYNCADTGWPRDWATWHADTAKSAMSAPLFAWLNSWYSAPCAFWQVPASPE
                     VRIGSAPVPPILLLQGKDDPATPLAGAQRMRRVLHGSRLLVDGGGNHAAYLNERNPCVD
                     DKAAHYLLTGELPQDGTCPAGGEKAAPSGG"
     aSDomain        complement(16460..17566)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_L3Q65_RS43910_Abhydrolase_1.1"
                     /evalue="5.50E-25"
                     /label="L3Q65_RS43910_Abhydrolase_1.1"
                     /locus_tag="L3Q65_RS43910"
                     /protein_end="451"
                     /protein_start="82"
                     /score="80.3"
                     /tool="antismash"
                     /translation="LLVNPGGPGASGLGTEKLVFSQLPRDVAQQYAAFSFDPRGIGAST
                     PVSCGDTSELAPHPASPYQPADLPQERKREGFAKQIAARCAANGKDLLPQVTTENAARD
                     MDRIRQALGKDKIDYLGYSYGTKLGATYATLFPAHTGRMILDSVVDPTATTYQTQFQQN
                     AALQARAEQLFAWTAERDSTYHLGATASAVKTAWNELREKLAARPADGKTGVSELDDLL
                     ASAMYGDWAWPSLMQAIASHRGGDSAGLNVAAGQARYAVDPGQLAYNCADTGWPRDWAT
                     WHADTAKSAMSAPLFAWLNSWYSAPCAFWQVPASPEVRIGSAPVPPILLLQGKDDPATP
                     LAGAQRMRRVLHGSRLLVDGGGNHAAYLN"
     misc_feature    17883..17898
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: medium, score: 28.45"
                     /tool="antismash"
     misc_feature    17883..17899
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: medium, score: 29.76"
                     /tool="antismash"
     misc_feature    complement(17884..17899)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: medium, score: 27.75"
                     /tool="antismash"
     gene            17910..18368
                     /locus_tag="L3Q65_RS43915"
                     /old_locus_tag="L3Q65_43910"
     CDS             17910..18368
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009073768.1"
                     /locus_tag="L3Q65_RS43915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_43910"
                     /product="DUF4396 domain-containing protein"
                     /protein_id="WP_101435430.1"
                     /transl_table=11
                     /translation="MNEHQHGASWSTAAQATLHCLTGCAIGEVLGMVLGTALGLHNAAT
                     VVLSIVLAFVFGYALTMRGVLKSGLALGAAFKVALAADTVSIAVMEVIDNTVVVAIPGA
                     MDAGLSSGLFWLSLALSLAIAFVVTVPVNKWMIGRGRGHAVVHAHHHH"
     gene            complement(18373..19047)
                     /locus_tag="L3Q65_RS43920"
                     /old_locus_tag="L3Q65_43915"
     CDS             complement(18373..19047)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020662008.1"
                     /locus_tag="L3Q65_RS43920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_43915"
                     /product="hypothetical protein"
                     /protein_id="WP_370648155.1"
                     /transl_table=11
                     /translation="MLERPLTYRLYATREGLVGGTTSSGHRITERDHFVALPSTKTVSS
                     KGRGTFTVRVCRTDGTRCEYAPVWDVGPWNEHDDYWNPAGRRAAFGSLPQGVPEAQAAY
                     QDGFNGGKDEHGRTVRNPAGLDLADGTFWDGLGLNGSSYVDVTFLWTGSAPATGVVTGG
                     APLVVRTSASNDAPSAGLAADSAQVPIECSVQDGTARWNRIGPGHYVPEAYLRADAAVP
                     SC"
     misc_feature    20779..20793
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.58"
                     /tool="antismash"
ORIGIN
        1 ggcggccagg tctgggtgga cggcgagccg atcgggttca aactgcgcgg cggcaagctg
       61 tacgagctgc gggagaagga cgtcgcgcgg cagcgcaggg acatcggcat ggttttccag
      121 cggttcaacc tgttcgggca ccggacggcg ctggagaacg tggtcgaggg accggtgcgg
      181 gtgctcggcg ccgacccggc gcaggcccgg aaagaggcgc tggacctgct cgaccgggtc
      241 gggctcgcgg accgagcggg cgcttaccca gggcaactgt ccggcgggca gcagcagcgc
      301 gtcgcgatcg cacggtcgct ggcgatgaag ccgaagctca tgctgttcga cgagccgacg
      361 tccgcgctgg acccggagct ggtcggggaa gtgctcgcgg tgatgggtac gttggctcgg
      421 gaggggatga cgatggtggt cgtgacgcac gaaatggctt tcgccgcgga ggccgccgac
      481 gaggtggtgt tcctcgctga cggcgcggtg gtcgaaaccg ggccgccgga gcgggtgctg
      541 aagtccccgg aacacgagcg gacgcggcag ttcctcgcgc gggtcctctc gtgacccgca
      601 ttccgccccg gtacctgctc cagttcgacg agcccgcggg ctacctggac ttcgcgcggt
      661 tcgggccgcc gtcgcacgcc gtcttagaca ccaccgcgcg gctgctggag gcgacgacca
      721 aggccggtcc gtccactgtg gacgagctga tgcggcagga aatccgggcg aaggcggcgg
      781 cagcacggct ttgcggcagc gacaccgacc acaccgtgct gctcccgcac accagcctcg
      841 gcctgttcca ggctgcgttc aacagccacg gcgaagtact cgtgtcggcc gcggagttcc
      901 cggccaacac gtacccgtgg gcgcgcgccg agcaggccgg acgcgtacgg atgcggcggc
      961 tggagggcgg ttacgtcacc gccgaccgtc tcgcggaagc gctcacgccg gaaaccgctg
     1021 tcgtttcggt gagcgcggtc gatttccgca ccggttaccg ggctgacctc gccgcattgc
     1081 gcgaggtggc cggcgatcgg ctgctggtgg tcgacgggat ccagggcttc ggggtcgtcg
     1141 acgcgccgtg ggaggtcgcc gacgtgctcg tggtcggcgg gcagaagtgg ctgcgagcgg
     1201 gctggggcac cgggttcgcg gtgctgtccg accgggcgct ggcgcggatg gacccgatcc
     1261 tgtccggctg gaccggcgcg cgcgaccctg gcttgttcga taacgagatc cacccggccg
     1321 acccgaccgc ggcgagctgg tcgatctcca acctcagccc ggtcacgtcc ggcgcgttcg
     1381 cggcggcgct cgaactggtc gaggaaaccg gcgtcgcggc gatcgcgggc cggatcgacg
     1441 aacgcgtcgg cgaactcgag gaggtgctgc gctcgttcgg cgcggagatc gtgtcggcga
     1501 ccgaacggcg ggccgggatt cttgcgtttt cgttgccgga caagcccgcc gagcaggtcg
     1561 gggcggcgtt gacggcggcg gggatcgcgg cgacggtgcg tccggaacac gtccggttgt
     1621 cgccgcacgc gtcgaccccg gccgcggctg ccgaacaggt gcgggacgcg ctggaaacgc
     1681 tgctgcggcc gcgtcgggtc gtgccggtcg cgtcggctgc gggcaccgcg acgcatgagc
     1741 tgctcaccgc gctgattccg gcggtggacg ggctggcggc gatgctcggg ccgggcaacg
     1801 aggtgctgct gcacgacctg tcgcggctgc cggattcgat cgtcgcgatc gcggggaagc
     1861 tcaccggtcg ttcggtcggc gggccgatga cggatctgct gctcgggctc gtccggcgcg
     1921 gcacgacgca ggacctgacc aactaccgca cgcacagtcc ggatggtcgc gagatccgtt
     1981 cgtccacgtt gtttttgcgt gacgccgagg gtacggcgat cgggtgcctg tgcgtgaaca
     2041 gcgaactgcc cgcggcggcg cagacgtcgg aggaacggcg ggaggagacg ttcctgccgg
     2101 acgtcgacag cctgcaacgg ttcctcgtcg gacgcgcgat cgggaagtcc gggattccgg
     2161 tggagctgat gaagaagcgc cacaagtcgg cggtggtccg ggagctggac gaggccgggt
     2221 atttcctgat caaggacgcg gtggaccacc tggccgcgca gctcgaggtg acgcggtaca
     2281 cgatttacaa ctacctcaac gagatccggg cctgatgagc gtcgtcgtac cggccaggtt
     2341 ggcgaaggcg gtgcggcggc gcgagggtgc cgcggctgag gcttggctac gggaactgcc
     2401 ggggttggtc gaggatgcct gcgtgaggtg ggactgtcag atcgcgggct ctccgctgca
     2461 cggggagacg gcgttggtgc tgcccgtcga atgcgccggg caggcggccg cgctcaagat
     2521 ttcgtttcct catcagcatt gtgcggcgga agcggcggcg ttgaagcact tcgacggtgc
     2581 cggggtggtt cggctgctgg aggcttctgc tgacagcagc acgcttttgc tcgaacgcgt
     2641 cggtcccgcg acactggaga cagtacgagt ggaggaagcg accgagatcg cgggcgagtt
     2701 ggcccgtcgg ctggcggtgc ccgccccggc cgggactcgg gcgctctcct cgacaaccgg
     2761 gccgtggctc gcgcagctgg atcagcaggc gatgccaggt ttgctgccga agcgcgaggt
     2821 tgatcgggcg cgggaactga tcgcgttcct cgccgatgac cggaccggca cgatgctgca
     2881 cggtgatctg catttcggga acgtgctgcg ggcgcgacgg gaaccgtggc tggcgatcga
     2941 cccgatcggg tggcgcggga cggctgcgtt cgacgcgttc accgttgtcg cgagaagaag
     3001 acgggcagat gacctgaccg cgttgatcac ccggttttcc cgggccgcac agacagatcc
     3061 gggcctggca gcgcgttgct gccaggcccg ggcggtcagt gcttatctgc accaggaaca
     3121 cactggcggc gcatggttcg accgcgacgt gctcctcgca cttatttcag gaacttctcc
     3181 accgcgtccg cggccgcggt aatcccgccg ttggcacgga tttccgagcg cagctcagcc
     3241 aacctcgcgg caacgtccga tgaactgctg acttcatcga cggcttcgcg cagggacttg
     3301 gcggtcacct ggtccgcggg cagatgcttg ccgactccca acgcttccag ctgcgcggcg
     3361 ttgccgaact ggtcgacggc ttgcggaatg gcgaccgtcg ggacgccgta ccacagggat
     3421 tccgtgcagc cgcccatgcc ggcgtgcgtg atgaaggcgg acgcgacgtc gagaatcgcc
     3481 agttgcggca ccgtttcgtg cacctcgacc gacttcggca gcgggccgag atcgtccttc
     3541 gagacgtgct tgccgatcga gagcacgacg tgccagtcct cgaattcggt gatgcagtgc
     3601 cggtagacgt ccagctggtc gttgtacgcg gtgccgaacg acacgagcag cacgggtttc
     3661 ccgtcggacg gcggtgtcca gtgctccgca gcgcgcgccg ggtcaaggca cgggccgacg
     3721 aactggacgc ggtcctccgg cacgcggtcg gcgttcggct gcatcgcgcg cgggatcagc
     3781 gacaggatcg gcaccggtcg cgcgagccac gtccaggcgt cttcggtgac tccgttttcc
     3841 gccagccact cggtgaatgc ccggtcgtag tccactccgg acggtgaggt gcggatcggg
     3901 tcgaggacgt cggcgagttc ttcctcgtag ccgtcccagg cgacgtaggc gggggagagc
     3961 tgcaccgcgg gcacgtcgta gcggaggccg agcagcgggg cgccaaggcc gccgatgtcg
     4021 tagagcagca ggtccggccg gtcctggtcg aaggtttcga tcagccgcgg gtggatcgcg
     4081 atggcctcgt cgaggaagac gcgcatcgct tcggccgggt cttccggcca ttccgcgtcc
     4141 ggaccgagcg ggaagatcgt gggatgcgcg acgacgtccg cgccggtcgc tccgaccagt
     4201 tcggcgagcg gttcgccgac gacgtagctg acccggtgcc cgcgtcgcac cagttcgcgg
     4261 acgatcccca gcgacgggta gatgtggctc ggcgcggaac agccgaccac gacgatgtgc
     4321 ttgcccatga ggcgaaagtg tcctttccgg acgagatgcg gtccggcacg cggaacggga
     4381 gccgcccgat ggcgggcggc ccggaaagtc gtgccgggat caggacaggc ggcggcgggc
     4441 gaagatcgtc atgaatccgg acggtagtgc ggctggtcgc ggggagcaac cggattagcc
     4501 ggcatagccg ccaggcactt gccacggtga acgactcggc atcgcccact acttttcaac
     4561 acaaccaact ttgtgttaca aagttcagga cagcgaagca ctgggggacg agatgacgga
     4621 agcgttcagg ctgaccggcc tggtgaagca gttcaagcag gtccgcgcgg tcgacggcgt
     4681 gtcgatgacg gtgcggcggg gcgaggtcgt cgcgctgctg gggccgaacg gcgcgggcaa
     4741 gtcgaccacg atcgacatgc tgctggggct cgcctcgccg gacgagggga gcgtgcgggt
     4801 gttcggcggt gcgccccggg cggcgctcga ctccgggcgg ctcgcggcga tggtgcagaa
     4861 cgggttcctg ctgcgggacg tcacaccggc cgagctggtc gagttgcatc ggtcgatgtt
     4921 cgagaatccg ctgcctgcca aggaggttta cgcgcgggcc gggatcgggg agttcgccaa
     4981 gcggcggtgc gggaagttgt ccggcgggca gctccagcgg gtccggtacg cgctcgcgct
     5041 caccggcgac ccggagctgc tgatcctcga cgagccgacg gcggcgttgg acgtcgacgc
     5101 gcggcgcgaa ttctgggcgt cgatgcacga gttcacggcg gctgggagga ccgttctgtt
     5161 cgcgacgcac tacctcgccg aggcggagga ctacgcggac cgcgtcgtac tgatgcggca
     5221 cgggaaggtc gtcgcggacg gcgcagtcga cgaggtgcgc gcgaatgtgt ccgggcgagt
     5281 gatcagggca gtcgtacagg gcgcccgtcc ggaagccttg gccgcgctcg acggggtcgc
     5341 cagtgcacgc gtacagggcg atcgtacgga actgggctgc acggactccg acctggcgat
     5401 ccgggcgttg ctcgcggcgt ttccgcaggc cagctcgatc gagatcacct ccgcggggct
     5461 ggaggaagcc ttcctcgccc tcacctccga cgagccgcag ggagcgctcc gatgaacctc
     5521 gtctacctcc ggctggagat cctgcgcatc gtccgcagcc cgcagttcgc gttgttcacc
     5581 atcgtggttc cgcttggcat gtttctcctg ttcggcgggt tgttcggcga tcaggtcggg
     5641 ccggacggca tcaaggcgag cgtcaccacg atgatcaaca tgggcgcgta cggcgcgatg
     5701 agcggcgcgt tgttcaccgg cacccgcgtc gcgaccgagc ggacggacgg ctggcagcgg
     5761 caactgcggc tcacgccgat gcgcgggccc ggctatctcg cggtgaagat cgcgtcctcg
     5821 atggcgatgg cgttgcccgt ggttctggtg atcttcgtgg ctggtgcgtt gcgcggagtg
     5881 cagttgacgc cggcgcagtg gctgctcagc gggctctcgt tgtggctggg cgcgctgccg
     5941 ttcgcggtgc tcgggcttct gctcgggttg ttcggcaagg gcgacacagt cggcgcgatg
     6001 accggcgcgt tgatgctgcc gctcggcgtg ttcggcgggt tgtggatgcc gctgtcgatc
     6061 ttgccggaat ggatgtcggc gctcgcgcat ttcttcccta cgtactggct cggccgcgtc
     6121 ggcacgctcc cggtggatca cgcgggcggg ctcggtctcg cggtcggcgt gctggcggcg
     6181 tggctggtcg tgcccgcgct cgtggtggtg cggcggttcc ggctgggccc ggtgaaggtc
     6241 gcgtgacgtg ttagcttccg tgctgcatga ggggtcagta cgggggaagg gcggtccggg
     6301 gtgaacaacg acgcggggga ccccgtcgag gacgaaggcg agccgctgtc cgtggcggaa
     6361 tcgctcgagc tcatcgcccg gcagaacgaa cggacgcgcc gggagctgcg agtcagcccg
     6421 gcgcgtctgt tcgccgtctg ggccttcgcc tggctggtcg gctgggggct cgtctacctc
     6481 tccgacgggc gatcggcggc gctcatgccc ggctgggtcg cggggatcgt cgtcgcggtg
     6541 ctcatggtgg gcgcgatcgt ttactccgcc tggcacggca gcaaaggcgg ccgcgggatt
     6601 cgcgggccgt cgcagcggat cggcgcgatg tacggctggg cgtggatgat ctcgttcgcc
     6661 gggatgagcc tgatcgacat ccggatcacg aaactcctcc ccgaaggctc ggatctcgtt
     6721 cccctgctgt ggtccggcac gtcgctgctg ctgaccggtg cgctctacct ggccggcggg
     6781 acgctgtggc aggacatgcg gcagtacttc ctcggtggct ggatcatcgt gtgcagtggg
     6841 gcgagcgtct tggtcggtgt gccaggcaac ttcctcgtcc tttcgctcgc gggcggcggc
     6901 ggattcgcgg tcgcggcgct ggtctatgtg gtgcggcccc gtgactgagc tgccggagct
     6961 cgaccccgtc atccacgccc aggcgcggct gcgcgtcacg gtcgcgctcg ctgggctccg
     7021 tccggccgac cagatcacct ttccccggct gcagcagctg ctggagatga ccgcgggcaa
     7081 tctctcgacg catctgcgca agctcgagga cgccgagtac gtcgagatca ccaaggctta
     7141 cgagcaccgc acgccggtca cgctcgtgcg gctcacgagc aagggccgcg ccgcgttcga
     7201 gagttacacc aaggcgttgc aacggctcct ggacgctgga acctgacatg tctcgctggg
     7261 tcgtgcactt ggacctcgac gcgttctacg cctccgccga acagctcacc cggccgacgc
     7321 tgcgcggacg cgcggtggtg gtcggcggta ccggacaccg cggtgtcgtc gccggggcga
     7381 gctacgaatc ccgcgagtac ggcgtgcggt cggcgatgcc gatgtcccag gctcggcggc
     7441 tgctcccggc cggcggcgtg gtgctgccgc cgcggttccg gttgtacgaa atcttgagca
     7501 agcaggtttt cgatgtcgtc ggcgaggtcg cgccggtgct ggaacggatt tccctcgacg
     7561 aggcgttcgc cgaaccgccc gcgctggctg gtgcgtcggt cgagcaggtg accgggtggg
     7621 ccgaggaact gcgggcgcgg atccgggagc ggactgggct cactgcgtcg atcggggcgg
     7681 ggactggcaa gcaggtcgcg aaaatcggct cggatcgcgc gaagccagac ggtttgctgg
     7741 tcgtgcctcc cgggaccgaa cgcgagtttc tggctccgct gccggtgcgc gcgttgtggg
     7801 ggatcggacc ggtcgcggaa gccaaactgc gcacgatcgg tgtcctcacc ttgggcgagt
     7861 tggcggcgtt gcccgagccg gacgcggtgt cgacgctcgg tggcgtggtc ggccgcgatt
     7921 tgcggcggct ggcgagcgga ttcgacgacc gtccggtcgc ggaacggggc gaagccaaac
     7981 aggtgagcgc ggagacgacc ttcgacgtcg acgtggtcga tctcgtccga ttgcgcgccg
     8041 aggtaaggaa aatcgcggct ggtgcgcact cccggctggt gaaggcgggg cgcgtcgcgc
     8101 gcacggtggt gatcaagctg cggcataccg acatgagcac ggtgacccgc tccgagacca
     8161 ccgcgtcgcc caccgatgac ctcgaacagc ttgccgctac tgcggaacgg ctgttgctcg
     8221 acccgcagga gttcggcgga gtgcggttgg cgggcgtcgc gttcagcggg ctttcagtgc
     8281 cgcatcagga cgcgttgttc agcttgaccg tgcccgccgc gacggaggag ccggtggtca
     8341 cttcggcgcc gtcgccgggc gggagcgcgc cagtgtcgtc gtcgggatgg cgcccgggcg
     8401 acgacgtggt gcatgccgag ttcggcacag ggtgggtgca gggcgcgggg cacggccggg
     8461 tgacggtccg gttcgagacg cgcacgtccg gtccaggcgt cgcgcgcacg ttcgaccaga
     8521 ccgacccggc gctggctcgc ggacagcccg ccgactgcct agcctgagcg tttcccctgg
     8581 tcacgaccgg ggtgttaacc cacaagagtg atgaggaagg atgtgccggg cagccgggca
     8641 aaggggatga tcatgacgaa cacgcgccgc gccgccgccc tcgccggggt cgcgctgatg
     8701 ctgacggcgt gtgggagcga agccgccccg caacggtcct cggccggacc ggcatcgtcg
     8761 tcggcggccg cttcgccgga ttcgttcacc gtcgtggcga ccggggacgt gctgatccac
     8821 cctcggctca ccgagcaggc cgaggcggac ggcggcggga agatcgacta ccggcagctg
     8881 ttcgccgggg tcaaaccgct ggtgtccggt gcggatctgg ggatctgcca cctcgaaacg
     8941 ccgctcgcgc cagaaggcgg gccgtacagc gggtatccgt cgttcagcgc gccgccggag
     9001 attgcggacg cgttgaagga caccggatac gacacgtgct ccaccgcgtc gaaccacacg
     9061 ctcgaccagg gcgcggcggg tgtgcagcgg acgttggaca agctcgacca gaccgggttg
     9121 aaacacaccg ggtccgcgcg ttcggctgag gaggcaggga agccgctgat cctggacgtg
     9181 cacggggtga aggtcgcgca gttgtcttac tcgttcgggt tcaacgggat caagcggcct
     9241 gccgggaaac cttggctggc caacgaaatc gaccccgacg agatcctcgc cgcggcgcgc
     9301 gaggcgaagg cggccggggc ggaggtcgtg atcgcgagcc tgcactgggg cgtcgagtat
     9361 cagcatgacg tgactgctga gcagaagcag ttggcgcaga agctgacggc gtcgccggat
     9421 ctcgacctga tcgtcgggca ccatgcgcat gtggtgcagc cgttccagaa ggtcggcggc
     9481 aagtgggtgg cgttcgggct cggcaatgag gtcgcgcggc acgacgaacc tcgcgggtcc
     9541 acggaggaag gggtcgcggc ccggttccgg ttcagccgcg ccggcgggaa gtggacggtg
     9601 gacaaggccg agtacgtgcc gacgctgatc gacctcgggc cgccgattcg gttgcgcgac
     9661 ctgacgactg cgccgccgag cgagcgagga aaggaagcgc tcgcgaatac cgacgaggtg
     9721 gtgctttccc ggggcgctgg ggatgacggg ttgagccgac tggggcggtg acggtttccg
     9781 ggtcggtggc ggcctagggc agtgggggtt gctgggcgct gcgctgttgt gcgctcgatg
     9841 ttgtggcggg cgatgggttc gatgcgcttg tcgtcgctgt ggggtgagcc ttgcggtgtg
     9901 cccagggcga tcgtcctggg cggacgatcg ggttgggcgg ctgtcttcgt tgggcgttcg
     9961 ccaggttcaa gttgttgtct ggggcggacg atcgcccgag tcagtggtcc cggcgggtga
    10021 tgagctgggc gatcgcggtc agttcggccg ttggccgggg ggctgggttg gcggcggtca
    10081 aggcggccag cgcgtcggtg agcagttcgt ctgcttgggc gtggctccaa gagcggcccc
    10141 cggcttcgtc gaccaaagcc gcggctttgg cgaggcagtc gtccgggagt ggctgtcggt
    10201 acagcattgc cagttcctgt ccggctgacg tgcccgaggt gagcgccgcg accacgggga
    10261 gggatttctt gcggctgcgc aggtccgagt agaccggctt gccggtgact gctgggtcgc
    10321 cccagatgcc gagcaggtcg tcgacgtgtt ggaaggcaag gcctagcgat cggccgaagc
    10381 ggccgaagcg ttcgacgtgc tcgccgcggc ctccgacgac cagtacgccg agcgtgcatg
    10441 ccgcgctcag cagggccgcc gttttgcctt gggccatgcg gacgcattcc gctacttcga
    10501 cgttcgttcg ctgttcgaac gccaggtcct cgtgctggcc gtgcagcagg tccagtaccg
    10561 cggtgctcag caggcgggcg gcggctgggc cgtcggggga caggacgtcg aaggccagtg
    10621 ccagcaggga gtctccggcc agcaccgctt gcccggtgcc gaagacggtc cacgcggtgg
    10681 ggcgatggcg ccgggtgcgg tcgccgtcca tgacgtcgtc gtgcagcagg gagaagttgt
    10741 gggccagttc gacggccacc gccgcgggga tcgcgtcttc cgggtctccg ccgcaggcct
    10801 ccgcgcacag cagcaccagg gccgggcgca gggctttgcc tccggcggcg ctggtggcgg
    10861 ttccggtttc gtcccaccag ccgaggtggt agccggcgat ccggcgcatc gacacgggca
    10921 gccggtcgac cgccgcgcgc atcgcgggtt cccagcggct ccggctccag tccagcacct
    10981 cggccacgga gcgggccccg gtgcgcgcgt ccaccgtcgt catcgttctt ccgcttccgg
    11041 gcgcagcacg gcggccacag tggacagtgc ggaggggctc gggacgatca ctgcgaaacc
    11101 acctaacgtc gaaaacgccg gaacccggcg gagcggtgtt ttccgggaga ggaatgcgaa
    11161 atcgtaagcg gcgccgcgca tcaacatagc aaggcggatg atctcgacaa tcactcgatc
    11221 gggtaaccgc gtccgattca cctgtttgcc gaagctcctt ttcgggcatt gccggtgctg
    11281 ttgtccggtc gacaacgaga ggcgcgtcac cgtgggtccg ctgccgtaac ccggtcgagt
    11341 gcgcaccacc ggtatccgag caattttccc ttgttgagca agggcaatcg ggggtacgcg
    11401 tggccgggac gctgctccga tccggcgaac cgcgcgggcg gtggacggcc acccggctga
    11461 atcgcgggtt tcgccgttgt ccgttccgga atcggctgga tagcgtcggc cagcgtattt
    11521 ccccgcgcga aaggaaccgg atgaacgtct acgtgaccgg ggtgttctgg gtcgtcggcg
    11581 cggcgatcgc ggccgcggtg atcggctatc tcgtccggcg cttcggctgg gacgagggcc
    11641 gccgcgacaa caacgacgcc gcgggccagg tgttcaccat cgtcggcggg ctgcacgcgg
    11701 tgctggtcgc cttcgtgctg atctcgctct tcgacgccgt cacggccacg cgcgagggtt
    11761 cctacaccga ggcggagggc ctggtcgccg ccacctggtc ggctcaggca ctgcccggcg
    11821 acaccggcga gcaggtgcgg cgcctggcca tcgcgtacgc gacgacggtg tcgaagcagg
    11881 aatggccccg gctcgtcgac gacgggccgg tcccggacac cggctggacg cagctcgacc
    11941 agatgcgccg cgtcgtcgcc agcgcgcagg ccagcgacga ctggacgaac gaccggaaga
    12001 aggacgccgc cgcccagctt tggcaggtct accaagcccg ccagacccgg ctcaccggcg
    12061 cggaaaccga cggcgtcggc tcggtcatgt ggttcgcgct catcctcggc agcgtcatct
    12121 cgatcctgct gcccaacctc ttcggcggca cgcggatggc cgcgcacctg gtgatcgtgt
    12181 cgacgctcgc cggcacgatc gtcctgctgc tctatgcgat ttaccagctg cagaaccctt
    12241 atgccggcgg cgcgaacgtg catccggacg cgttcacctc ggcgatctcg cggctcggct
    12301 gaccggtgcg aggttcccgg tacctgactg tggtggccgc cgcggccgcg gtcgccgggc
    12361 tgctcgtcgc gtccggatgg ctggctccgg ctcgccagcg cgcggccgcg acgtcctgcc
    12421 gggtgctgca ggtcgaaagc cgtgacgggc agtcgtccga catcgtgcgg ttgaccttgc
    12481 cctccggcgc gcgacatctg ttgcaccaca gtccgttcgc gctgaatgcc atcgcgtatt
    12541 cggccgcgca ggacgtgacc tacggcgtcg ccgacggtcg tttccacgac ggctggcacg
    12601 cggtgcggat cgactccgga ggtgagttga ccgatctcgg cgcggttggg cgagaaacgc
    12661 accatggcgt gtggagctgg gtcactggcg cgacggccgg ggcgatgtcc ggtagctctt
    12721 ggtacgtgaa gcgggcgacc agtctgtaca cagtggacgt tgacccgcac agctccggtt
    12781 acctcactgc gaccgggccg gtgttgctgc atccgtggtg gctcgcgtcc ggcgtcgacg
    12841 atttcgcata caacccggaa gacgctctgc tgtacggggt ttcgtccgct gccgagggcg
    12901 cggtggtcac ggtgaacccg gtgagcggaa cggtcgcgaa ggtgccgggg gagcagtttc
    12961 cggcggcgac ttacggtgcc gtcgtgttcg ggccggacca caagctctac gcgaccgcga
    13021 actggatcga cgggcggagc gtcacgtacc ggatggacgg cggttccgcg gtcgaggtga
    13081 gcacagggcc gccgttggtg atgtccgatg gcgccgggtg tttggcggaa cccccgccgc
    13141 caccgcctcc gccaccaccg cctccgtcgt cctcgacccc gccgacgacc tcgtcctcac
    13201 cgaccacgac gccgtcctcg ccgtccccga ccccgacccc gtcgagctcg gcgagcccca
    13261 cgccgtcgtc caccccggtg cccccgccgc acccatcgtc accaccgtcc ttcccgccac
    13321 ccacgacgcc gagtccggtc acgcctaccc ctaccccgca accaccggac gcgatcatcc
    13381 agccgatccc gatgcctcag cccccggcac cgtcgcgcgc agccccggtg aagggcatcc
    13441 cgaaaccgcc cgagaagcgc acggcgaaag cacgcgacaa cgtcaagaag cagcgacgct
    13501 ggggtgtcgc cgcggtcctg ctgatcgtcg gaggaggtgc ggtagcggct cgagcacggc
    13561 gcgctcgtta acgcggcggt cgtctcgatg acggacgttg tccaactcgg ccgtcaagac
    13621 tccctccggc gtcgaaacga cgccagagga ggagaaagcc gatgaaacgc gtgaagatcg
    13681 ggctggtcgc cggggcgctg gtgctgccgc tggccgccgc gggcccggcc gaggccaagg
    13741 gccgtccgga cgaccattac cgggtgcggg ccgggcacac gctgcaggtg cgcggcgacg
    13801 cgcagcgcga cggtgcggtg gtgcggcaca ccgatcccgg ccacggcgcg ctggccatcg
    13861 gcccggacgg atcgttccgc tacacgcccg ccgccgggtt caccggacgc gacacgttca
    13921 cctacaccgt gagcgacgcg gtccggctgt acccgacgga cttgccgccg ctcggcaccg
    13981 tcggcggcgt caagatcacc ggcggcgggt acgggtccgc gctgactccg gtgccgggtt
    14041 cgcgcgacga gttctacggg ctcaccgacc gcgggccgaa cgtcgacgcg ccggacgggt
    14101 ccaaagtgga gccgctgccg tcgttcacgc ccgccgtcgg caagttccgg ctcaagggcg
    14161 gaaaagccgt gctggagcgg aatattccgc tgcgcgcggc cgacggttcg ccgtacaacg
    14221 gccaggtcaa caccctggcg aacaccggcg agaccatcgt ggacctcaac ggcgcgaaac
    14281 tgcccgcgtc gccgaacggc tacgactccg aagggctcgt cgcgcaacgc gacgggacat
    14341 tctgggtgtc ggacgagtac ggcccgttca tcacgcattt ccgtgcggac ggccgggcga
    14401 tcgagcggct ctcgcccttc gacggttcgc tgccgaagga actgaagaac cgcgtgccga
    14461 acaagggcat ggagggcctc gcgctcacgc cggacggccg gacgctcgtc ggcatcatgc
    14521 agtccgcgct gcagcagccg gatctcacga agaagcccag caaggtaccc gcgctgcgga
    14581 tcgtgacggt cgacctgaag acccgcgcca cgcacgagta cgcctacctg ctcgacaacc
    14641 cggacgagac cagcaccgcg gtctccgaga tcaccgcgtt gtccgcgacc cgcttcctgg
    14701 tggacgagcg cgacggcaag gccgagccgg gcgcgtacaa gaagctgttc gagatcgacc
    14761 tgagcaaggc gaccgacctc ggaccggcgg cgaaggtgcc aggcgcgacc tacgacgcgg
    14821 tcaagggcgg gctgctcgtc gacggcggca agagcatcga ggcgtacgtc ggcaaggcca
    14881 ccaccgcgga ggccgctgac gcgctggcga aggtcggtgt gacacccgcg gcgaagaagc
    14941 tgttcctcga cgtcggcggc ttggtgaccg ggctcgaccc gagcggcggc ttcttcggcc
    15001 acgacaaggt ggaaggcgtc gcgacgaccg acggcgaccg caccgtggtg atcagcaacg
    15061 acagcgactt cggcatcgac ggggttgcga actcgacggc tccgtacacc ctgcacgcca
    15121 aggcgcagcc gaatggccgt caggacgacg gcgagtacct gaaggtggac atggcgaagc
    15181 tgccggcccg gacgcgcact ctgacggtga ccgtcgacgt gcgctgagga ccctcagtac
    15241 ttgaactgat ccacgttgtt ctgcgtgatc agcaggggat cgccgagcag gaccgtccgg
    15301 gtggccgcgt cgtagcgcac cgcggggagc tccgggctca cgttgttcct gggcttgagc
    15361 ggggcgtcgg tcgcgagctg ctcggcggtc caggcggtga ggtagccgag ggattcgacg
    15421 ttccacagca ccgtcatgga gcaggaaccg tcgaccaggt acggcttcat cgtctgcggc
    15481 gtgccggtgc cgacggtgaa gacctggccg atcttctgct gatcacgcac cgctcgtgcg
    15541 atgccgggcg tcgccgtggt gcactgcccg atcatgccgg tgagtttcgg atgccggttg
    15601 aggatctcct tcgccagctt cgtggcggtg gtggtgtcct cgtcggcgta caccgtctcg
    15661 actagcttcg cctgcggata gcgttgtgcc gcatacgttt tctcggcttc gatccaggag
    15721 ttgaggttcg ctgccgcgcg cccgcacgag acgatcgcgt actcgccggt cccgccggtc
    15781 ttcttcatca gcgagtcgac cagcgccgag ccgatgccct cggccgtcgt ctggttcacg
    15841 aagacctcgc gctgggaatc ggcggcgtcg gtgtcggtgg tgagcacgtg gatgcccttc
    15901 gcccgcgcct ccgcgatcgt cggggccagc tccgccggat cgttcggggc gaccgcgatg
    15961 acgtccacgc gttcggcgat gagctggcgc aggatcgcgg tttgcgcggc cgggtcgacc
    16021 gacgccggcg cgcggaggaa ccacttcgcg ccgagccgtt tggcggccag catgccgccg
    16081 gcgttcatcg cgtcgaagta cgggatgccg ccgattttcg gcacgaaggc gattttcgcc
    16141 tgctcggggg ccgagccgga caggaccggc gagcaactgc ccgccagcgc cgccgcggtc
    16201 gccaccagcg ccgcgcccag cacgagcgtt ttggtccgcc ctcgcatccc ccaccgttcc
    16261 ccggctatgt gacctggcag ccgaaggtag ggccagcggc ggcagggggt caaccgaacg
    16321 cgaccaaacg gttacgcaag cgagttcaac cgccggaagg cgcagccttc tctccgcccg
    16381 ccggacacgt cccgtcctgg gggagttcac cggtcagcag gtagtgcgcg gctttgtcgt
    16441 cgacgcacgg gttgcgctcg ttgaggtagg cggcgtggtt gccgccgccg tcgacgagca
    16501 gtctcgaccc gtgcagcacc cgacgcatcc gctgtgcgcc ggccagcggt gtcgccgggt
    16561 cgtctttccc ttgcagcaac aggatcggcg gcaccggagc agagccgatc cggacctccg
    16621 gcgacgccgg gacctgccag aacgcgcacg gcgcgctgta ccagctgttg agccaggcga
    16681 acagcggcgc ggacatcgcc gacttcgcgg tgtccgcgtg ccaggtcgcc cagtcgcgcg
    16741 gccagcccgt gtcggcgcag ttgtaggcga gctggccggg gtcgaccgcg taccgcgcct
    16801 gtccggcggc gacgttcagc ccggcggaat ccccgccgcg gtggctcgcg atcgcctgca
    16861 tcagcgacgg ccaggcccag tcgccgtaca tcgcggacgc cagcagatcg tccaattcgg
    16921 acactccggt tttgccgtcc gccggtcgtg ccgcgagttt ctcgcgcagt tcgttccacg
    16981 cggtcttgac cgcggacgcg gtggcgccga ggtggtacgt gctgtcgcgc tccgcggtcc
    17041 aggcgaacag ttgctcggcc cgcgcttgca gtgcggcgtt ttgctggaac tgcgtttgat
    17101 acgtggtggc cgtcggatcg acgacgctgt ccaggatcat ccgcccggtg tgcgccggaa
    17161 acagggtcgc gtacgtggca ccgagcttgg tgccgtagga atagccgagg tagtcgatct
    17221 tgtccttgcc gagcgcttgg cggatccgat ccatgtcgcg cgccgcgttc tcggtggtga
    17281 cctgcggcag caggtctttc ccgttcgccg cgcatcgcgc cgcgatctgc ttggcgaagc
    17341 cctcgcgttt ccgctcctgc gggagatcgg ctggttggta cggcgaggcc ggatgcggcg
    17401 cgagttccga ggtgtcgcca caggaaaccg gtgtgctcgc cccgattccg cgcggatcga
    17461 agctgaacgc cgcgtactgc tgtgcgacgt cccgcggcag ttgactgaac acgagtttct
    17521 cggtgcccag cccggacgcg cccggtccgc cagggttcac cagcaggaaa tgcggcgcgc
    17581 tgagactgcc catgccggac acggtgaggg tgatctgctt cccgttcggt ttcgcgtagt
    17641 cgagcggcac tcgcaggctc gcgcacgaca cctgccgcgg tgtcccggcc gggcacgcgc
    17701 cccacttgag cgaggacgtg cgcgcgctgg cggccggagc gctgaggagg cttcctggaa
    17761 ggagaacgag gacgaatgcg gcggcgcgac gacgcgccga gttgatcacc acacttccgg
    17821 ttataccgat tcgccggagc ggccgggcga cagtcatcac atcgggcgac cttgcgccat
    17881 ttatacccct aaggggtata gtcgcaggca tgaacgaaca ccagcacgga gcgtcttggt
    17941 ccactgccgc tcaagcgacg ctgcactgcc tcaccggttg tgccatcggc gaagtgctcg
    18001 gcatggtcct cggcaccgcg ctcggcctgc acaacgcggc cactgtggtg ctgtctatcg
    18061 tgctggcgtt cgtcttcggc tacgccctca ccatgcgcgg ggtgctcaag tcgggcctcg
    18121 cgctcggtgc cgccttcaaa gtcgcgctcg ccgccgacac ggtgtcgatc gcggtcatgg
    18181 aggtcatcga caacaccgtc gtcgtggcga tcccgggcgc gatggacgcg ggattgtcga
    18241 gcggcctgtt ctggctgtcg ctggcgttgt cgctcgcgat cgccttcgtg gtcacggttc
    18301 cggtcaacaa gtggatgatc ggccgcggtc gtgggcacgc cgtcgtgcat gcccaccacc
    18361 atcactgatg gttcagcagg agggcacggc cgcgtcggct cggagatagg cctcgggcac
    18421 gtaatgcccg gggcctatcc ggttccagcg cgccgtgccg tcttgcacgg aacactcgat
    18481 cggcacctga gcggagtcgg cggccaatcc ggccgatggc gcgtcgttgc tcgcggacgt
    18541 gcgcacgacc agcggggcgc cgccggtcac cacgccggtg gccggagcgc tgccggtcca
    18601 caggaaagtg acgtccacat agctgctgcc gttgagcccg agtccgtccc agaacgtgcc
    18661 gtcggccagg tcgagaccgg ccggattgcg cacggtacgg ccgtgttcgt ccttgccgcc
    18721 gttgaaaccg tcttggtacg ccgcttgtgc ttccggtacg ccttgcggca acgaaccgaa
    18781 tgccgcgcgc cggccggcgg ggttccagta atcgtcgtgt tcgttccatg gcccgacatc
    18841 ccacaccggc gcgtactcgc agcgcgtgcc gtcggtgcgg cacacccgga cggtgaaggt
    18901 ccctcttccc ttggaggaca ccgttttcgt ggacgggagc gcgacgaagt ggtctcgttc
    18961 ggtgatccgg tgcccgctcg aggtggtgcc gccgacgagt ccttcgcggg tcgcgtagag
    19021 gcggtaggtc agtggtcttt ccagcactct ccggccgtgc ttcggtttgg ccgaggccgg
    19081 agctggagtc gacaaagcga taactgtcac cgcaagaagg acgtgaccag ccgcttttct
    19141 ggtgttcatc agcgcatcgt ggcccggcgc acgggtttgg ccgcgcaacc gggcccgcgc
    19201 gtcaggcgga cacgatccgg tgcggcccgg tcttgcgcgg ccggtcgtcg accggggtgt
    19261 cggcggacag ctcgcggcgg atggcccgcg cgcgttcggc gtagctgcgg gaccgttccg
    19321 gctggctgag cgcggagtgg agctcgccga ggagctggga cgcgtgggct tcggagcggc
    19381 ggtctccgtt gcggcggtgc acgctcagcg agttcaccag cagcagctgc gcgtgcgcga
    19441 gatcgccgct gtacaggcac agttcgccca ggttctggtt cgcgtagccg acgcagtggt
    19501 cgtcgccgag atcggtgaac acggcgatgg cgcgcgtgac gtgttcgcgg gcttcggcga
    19561 ggttgccctc gcgctggtgc aggagcccga gtcgttgcag cgcatgggct tcccggtgcc
    19621 ggtcgccgat ttcgcaggac agctccagtg cgtcggtgta ccagcggcgc gcggtcgcgt
    19681 agcacttgcg cgcgacccag atcgaaccga tcgcgatccg gatcaccgct tcgccgtgcg
    19741 gatcgcccgc ttcgccgaac agccggagcg cttcgtgaca gggttcgagc gcgcggtcgg
    19801 gttggccttg catccgcagc acggtgccga ggccggcgta ggcctcgccg agcccttgct
    19861 ggtcgccgat ccgttggtac agctcgcgtg ccgcctcgaa ggcgaccatc gcgtccgcgt
    19921 cgttgtcttg gtacagcagg acttggccga ggttgcgctg gacgaccgcc tcgccgcgga
    19981 tcgcgcctgc ccggcgcgct gcttccagag cgatcaggtg ggtggcgtgc cagtcgtcct
    20041 ggtggccgcg gaggtcgaag tacggggtga gggccgcggt gagccgccag gtcaggtcgt
    20101 cgaaaccgcg ttcggcggcg agcccgacgg cggcgacgca ggtggcgcgt tcggcggcga
    20161 accaggcggc gggatcggtc aggagccggt cggcttccgg cggcagggtc aggtcggtgt
    20221 cgtcgtggta ctggccgaag aagtggatcg gcatgcgttc ggcggcttct actgccagcg
    20281 ccagatatcc ctccagcacg cggccgatcg cggtgcgggt ttcggcgggc tcggccagtt
    20341 ccgcggcgta gacgcgcagg aggtcgtgca ggcggtagcg cggctgtccc gcgacgtcgg
    20401 tggcgaccag ttccaccaag tgcgcgtcga cgagcacgtc gaggacgtcg tcggcggacg
    20461 ggcggcccag taccgcggcg actgcccagg cggggaagtg caccgggccc agcgcgccta
    20521 agcggcggaa ggccgcggcg gcggacatcg gcaggaggtc gtagctcagg gtcacgctcg
    20581 cccggacggc caggtcgccg acgcgcagct cgtccaggcg gcggtgctcg tcgtggagac
    20641 ggtcggcgag gatgcgcaac gaccaggtcg gccggtgggt gagcttggct ccggctaccc
    20701 ggatcgcgag cggcaaatgt ccgcattggc gcaggatcgc cgcggcgtct tcgggttcgg
    20761 cggctactcg ttcgtggccg acgatgcctt ccagcagacg cgcggcttcc ggttcgggca
    20821 ggaggtcgac gtcgaccggc atcgcgccgg cgagatcggg caggcggatt cggctggtga
    20881 ccagtacggc ggacgcgccc gcgccgggga gcagcgggcg cacctgggcg gcgctgcccg
    20941 cgtcgtccag gacgatgcac atccggcgcc cggcgagctg ggaacgcagg agcgcggagc
    21001 gttctggcag gtcccggggg agg
//
