LOCUS       NZ_CP091381            22313 bp    DNA     circular CON 18-AUG-2024
DEFINITION  Amycolatopsis sp. FU40 chromosome, complete genome.
ACCESSION   NZ_CP091381
VERSION     NZ_CP091381.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. FU40
  ORGANISM  Amycolatopsis sp. FU40
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 9944196)
  AUTHORS   Reisman,B.J. and Bachmann,B.O.
  TITLE     Biosynthesis of Apoptolidin Family Glycomacrolides
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9944196)
  AUTHORS   Reisman,B.J. and Bachmann,B.O.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-2022) Chemistry, Vanderbilt University, 1234
            Stevenson Center Drive; Room 7330, Nashville, TN 37235, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 23-JAN-2022
            Assembly Method                   :: Flye v. 2.9
            Assembly Name                     :: NFU40_flye_2.9
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 47.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_021903635.1-RS_2024_08_18
            Annotation Date                   :: 08/18/2024 04:30:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,491
            CDSs (total)                      :: 9,417
            Genes (coding)                    :: 9,360
            CDSs (with protein)               :: 9,360
            Genes (RNA)                       :: 74
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 7 of 57
            Pseudo Genes (incomplete)         :: 50 of 57
            Pseudo Genes (internal stop)      :: 5 of 57
            Pseudo Genes (multiple problems)  :: 5 of 57
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:13:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 9013957
            Orig. end                         :: 9036270
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP091381.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Brian O. Bachmann,
            Vanderbilt University.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22313
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="37"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22313
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22313
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12313](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12313)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(381..941)
                     /locus_tag="L3Q65_RS42750"
                     /old_locus_tag="L3Q65_42745"
     CDS             complement(381..941)
                     /EC_number="3.4.24.-"
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020662233.1"
                     /locus_tag="L3Q65_RS42750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42745"
                     /product="snapalysin family zinc-dependent metalloprotease"
                     /protein_id="WP_037818340.1"
                     /transl_table=11
                     /translation="MSRKFVLSGAVALALAAAPLSGAVAVAAPAPSAVASATVYYSTSG
                     APSFRAAINAGAANWNRAVTNVKLVERSSGATLRYVEGNDPRGSYAQTDGHGHGTIFID
                     YTQARQYDNTRITAHETGHALGLPDHYSGPCSELMSGGGPGPSCHNANPNSQEASRVQR
                     LWANGLSAVSGPQQRIYDHSPVG"
     gene            complement(1088..1699)
                     /locus_tag="L3Q65_RS47535"
     CDS             complement(1088..1699)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009073393.1"
                     /locus_tag="L3Q65_RS47535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YbaB/EbfC family nucleoid-associated protein"
                     /protein_id="WP_182892560.1"
                     /transl_table=11
                     /translation="MDDQGWLDDFQRRIDEMQAKSAALQETLSTAEGRAKSGDGLVSVS
                     VAPNGALKNLEIDDRALRHGGARLTASIMDAYGKAQRQVSRDVIDAFEPIAGDSEMMNV
                     VKSYLPEPEEEPEPAPEPPRSEPPARYAGPPPGSTTPPGSAAYGRPMPPPGGATHSRPP
                     MPPPGTTPPPPAPAPEPPRPTSGPHRRRAAGEDDDEMQPW"
     gene            1825..2442
                     /locus_tag="L3Q65_RS42765"
                     /old_locus_tag="L3Q65_42760"
     CDS             1825..2442
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020494555.1"
                     /locus_tag="L3Q65_RS42765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42760"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_182892559.1"
                     /transl_table=11
                     /translation="MSEEVQARTRNRWGEGERLRGEILAAASRLLSELDGEDALTIRGV
                     ARAVGIAPASIYQHFSDRAALVTGLAEHEFGRLRLAMEAAESRVPADDAVGRLRALLHA
                     YCRFAMDNPGHYRLMTANGSSRTSPDVRPEGPTIDFVDRISAAFARCAESGAELRVPAE
                     RAGVIAFVGAHGRVALFHSSGRQPGEDAVVNFADELLSLIFA"
     misc_feature    complement(1826..1840)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.0"
                     /tool="antismash"
     misc_feature    2534..2547
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.81"
                     /tool="antismash"
     misc_feature    complement(2557..2570)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.05"
                     /tool="antismash"
     misc_feature    2557..2570
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 19.29"
                     /tool="antismash"
     gene            2593..3801
                     /locus_tag="L3Q65_RS42770"
                     /old_locus_tag="L3Q65_42765"
     CDS             2593..3801
                     /EC_number="1.14.-.-"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016712 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen, reduced flavin or flavoprotein as one
                     donor, and incorporation of one atom of oxygen [Evidence
                     IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013225331.1"
                     /locus_tag="L3Q65_RS42770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42765"
                     /product="cytochrome P450"
                     /protein_id="WP_237598161.1"
                     /sec_met_domain="p450 (E-value: 2e-20, bitscore: 72.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADARPVAQFPMSRGRCPFDPPPDLDRKLRDDPVSRVRIWDGSEP
                     WLITRYEDVRAMLTDPRVSADPTRAGYPSQTPGVKARRSRFRSFIGMDDPEHAAQRRLL
                     TGDFMVKKVQRMRPRIQQIVDELLDEMLAGPKLADLVQAFALPVPSLVICELLGVPYGD
                     REFFHRCSKILVSREATAEQALAATEELLDYLARLVEKKIDDPADDVFSRLATGQVATG
                     AMTVEEAASMGQLLLVAGHETTANMIALGTVALLENPDQLAAVRDGDDALLANAVEELL
                     RYLTIVHSGRRRVALEDLEIGGQTVREGEGLIAATDVANRDETQFPEPDKLDVTRKARH
                     HVAFGYGVHQCLGQPLARVELQVVYRTLYRRIPTLRLAAPLDELKFKHDMVVYGVHELP
                     VTW"
     gene            3815..4009
                     /locus_tag="L3Q65_RS42775"
                     /old_locus_tag="L3Q65_42770"
     CDS             3815..4009
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1265: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009073400.1"
                     /locus_tag="L3Q65_RS42775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42770"
                     /product="ferredoxin"
                     /protein_id="WP_182892557.1"
                     /transl_table=11
                     /translation="MKVVVDQSRCVGAGQCVLVAPEVFDQRDEDGIVVLLRENPPEELH
                     ARAKEAAQLCPALAIEVDG"
     gene            4059..4841
                     /locus_tag="L3Q65_RS42780"
                     /old_locus_tag="L3Q65_42775"
     CDS             4059..4841
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003061603.1"
                     /locus_tag="L3Q65_RS42780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42775"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_182892556.1"
                     /transl_table=11
                     /translation="MVVFAGQGDARRSLELLWRTGSEPRSAPGPKPALSVDLIVAAAIE
                     LADAEGMSALSMRAVGERLGRTAMALYTYVPSKTELIDLMCDQAFGDLRDDHDLSGGWR
                     PALLELAGDLWEFHLRHPWLLQVSYARPVLGPGEFRMQETVLRVLFATGLPAGQVRRLV
                     GALLNVVRGAVQIAAESRLALKETGLSDEDWWRARTSALGELAPDLAERYPNVARLGEE
                     SAPPPAGVSYLEHEARLSFDAGVAVLADGIEAAVCRGS"
     gene            complement(4874..5629)
                     /locus_tag="L3Q65_RS42785"
                     /old_locus_tag="L3Q65_42780"
     CDS             complement(4874..5629)
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005440532.1"
                     /locus_tag="L3Q65_RS42785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42780"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_182892555.1"
                     /transl_table=11
                     /translation="MRTFDELVDEAASVSVDGWDFSWLDGRASEQRPSWGYQRLLGERL
                     RDVQSVVDIQTGGGEVLAGVPVLPPLTVATESWPPNLEKAAALLEPRGATVVADTDEPP
                     LPFQDNTFEMVVSRHPVTVWWDEIVRVLKPGGSYLSQQVGPWSVFELVEYFLGPQTPEV
                     RDSRHPDRAKAEAEQAGLEVVDLRFEELRTEFHDIGAVIYFLRKVIWMVPGFTVKEYLP
                     RLRELHEELREGPFVATTTRYLIEARKSS"
     gene            complement(5640..5870)
                     /locus_tag="L3Q65_RS42790"
                     /old_locus_tag="L3Q65_42785"
     CDS             complement(5640..5870)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013223223.1"
                     /locus_tag="L3Q65_RS42790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42785"
                     /product="ferrous iron transport protein A"
                     /protein_id="WP_182892554.1"
                     /transl_table=11
                     /translation="MTPLTELPLGTRVVVRYRIEGGFTDALGPLRARDADTCTVETKRG
                     LVVVPLAAVVAAKPVPPAPQRKSSGPPAPNL"
     gene            complement(5867..6106)
                     /locus_tag="L3Q65_RS42795"
                     /old_locus_tag="L3Q65_42790"
     CDS             complement(5867..6106)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020662224.1"
                     /locus_tag="L3Q65_RS42795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42790"
                     /product="glutaredoxin domain-containing protein"
                     /protein_id="WP_182892553.1"
                     /transl_table=11
                     /translation="MSNPIVYGASWCPDVKRSRALLDAKGVEYDYVDVEADPAAEARVR
                     ELQDGARRIPTIVFADGSHLVEPSDDELNAHLAK"
     gene            complement(6103..8220)
                     /locus_tag="L3Q65_RS42800"
                     /old_locus_tag="L3Q65_42795"
     CDS             complement(6103..8220)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009073410.1"
                     /locus_tag="L3Q65_RS42800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42795"
                     /product="phage holin family protein"
                     /protein_id="WP_182892552.1"
                     /transl_table=11
                     /translation="MSTPAPAKGRLLRGGRVVARVLLVWVAVTGALRLLDAWLDGFTMQ
                     SWWQPTVCALILGLLVSVVWPLVVRVAWPIAYFTLGVGTYILLSAAALAILQAVPGVEL
                     HGFSTAVVITVAMSAVGAVISSVLAVDEDEIFFRRAARRRRKAKHRTDFADQPPGVVFL
                     QIDGLGYDTVRRAVRDGDMPTFAKWLSEGTHSLTRWHTDWSSQTGASVCGILHGSNHDI
                     LGFRWYEKDRDHVMACAHPSDAAEIERRHSDGRGLLSIGGASHGNLFSGDAAHVSLTMS
                     SVPVLTPRKRRGRVGAGYRAYFANPVNVLRTFGVALADVVRELSAAAKQRRAGVLPRIP
                     RGGVYPLARPGTTVIARDVVVSAIIGDMLAGRPVVYADFLGYDEVAHHSGIERFDTLEV
                     LRSIDQQFARLLRAGRLSPRKYHIVGLSDHGQTQGQAFVDRFGETVEALVGRLCGGEPV
                     AEQGKRRQAESWQVNAALAEATATGGLIARRLRARVEGAEGAENRPRTATGSPGQVTRV
                     APGVVAVVSGHLAMVSFTEHEGRVELETIEREYPDLLPTLVDHDGVGFLLVRSREFGPV
                     VLGRDGLKRLATGVVIGEDPLAGYGPYAAELVQRVDSFPHCADIMINSRYDADSDQSSP
                     FERHVGSHGGLGGPQQRGFLLHPREFPAPGEPVGAESVHRVFRDWLTFLGHPEPGAAEG
                     KPAVVPSEVVS"
     gene            complement(8217..8804)
                     /locus_tag="L3Q65_RS42805"
                     /old_locus_tag="L3Q65_42800"
     CDS             complement(8217..8804)
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1188: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020662222.1"
                     /locus_tag="L3Q65_RS42805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42800"
                     /product="DedA family protein"
                     /protein_id="WP_182892551.1"
                     /transl_table=11
                     /translation="MNWTDPSAIGYPALFGGVLLGSVIPIVPTGAVVGAAAAVAMTTDH
                     LSLPLVILLAVAGAYLGDVITFAVPRFGSEPLLRFVERRQQAERLAKGREQFARRGWQL
                     VVIGRLVPAGRIPVLLAAGTLGYPWRKFLPSGLLACVLWAVAYSLLGILSGGIFDSPLI
                     ATLLATVLVLLVTVVTTLISKKRAAHQAGGHR"
     gene            complement(8801..9592)
                     /locus_tag="L3Q65_RS42810"
                     /old_locus_tag="L3Q65_42805"
     CDS             complement(8801..9592)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020662221.1"
                     /locus_tag="L3Q65_RS42810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42805"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_237598162.1"
                     /transl_table=11
                     /translation="MTSPNLHFLGHATTRVELAGQVAITDPVLTRWVGPLTRVAPKPDI
                     SAWTAVDIVLISHLHGDHLHLPSLKLLGKATRIVVPRGAGSWLTKRGFTEVEELSPGQT
                     ITSGDLRITATEAVHSGHRWGPRLTHGPQSPALGHLLEGNNHRLYSAGDTDLFPGMADL
                     GPVDVALLPVWGWGPNLGPGHLTPERAAEAAALLQARTAVPVHWGTLAVPGIHRTAKMR
                     QLLVEPPRTFAHHVRCKGLDTEVLHTRPGSDVLLPTREERG"
     gene            complement(10001..12313)
                     /locus_tag="L3Q65_RS42815"
                     /old_locus_tag="L3Q65_42810"
     CDS             complement(10001..12313)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009948856.1"
                     /locus_tag="L3Q65_RS42815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42810"
                     /product="germacradienol/geosmin synthase"
                     /protein_id="WP_237598163.1"
                     /sec_met_domain="T1TS (E-value: 7.9e-80, bitscore: 268.4,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQPFVLPEFYLSYPARLNPHLDGARKHSKAWAYTMDMVDVPQHGT
                     VIWNEHDLDSHDYALLCSYTHPDAAPRELDLVTDWYVWVFYFDDHFLELFKRTGDIEHA
                     RDYLDRIARFMPAEGEITETPENPVERGLTDLWNRTVPHRSAAWRRRFRESTRNLLDES
                     LWELANINENRVANPIEYVAMRRKVGGAPWSANLIEHSLNAEVPDEIAAKRPMEVLRDC
                     FADAVHLRNDLFSYQREVEDEGELSNSVLVFEKFLSCTTQEAADAVNDLLTSRLHQFEH
                     TALTEVPALFDEHGVQLPGRAETFAYVKGLQDWQSGGHEWHLRSSRYMNKGALDARGGP
                     ELLGGPSGLGTSAARIFRSIATTAPQRTRAFTHQPHEQLGPVTLPSLPLPFPLRLSPQL
                     AAERKKIADWPRRMGILSEGIWDIVRLRASDVPLATAGLCPDAPAEQVSLTNDWLTWGT
                     YADDYYAEVLAHDLPAARLTTERLKLFMPTDGEPPPPPQTALETGLADLWQRTTGPLSP
                     AEREAFRATVESMIDAWVWEVAGQVQNRIPDPIDYVEMRRRTFGSDLVTSISRLTNSRT
                     VPKEIHRNRVIEALEDSAADYAWLINDLFSYRKEIEYEGGLHNAVLVVRSFLDVGQDRA
                     IRIVADLAEARLAEFRHAADVGLPGLFADYGLDAEARDTLTGYADLLKNLMTGIANWHH
                     ESARYTDEELDRVRDVPVTAEPSEPTKPPAAKAMEHPGCTGTPYVPIDAKPRLRLTATG
                     LGTKSLHIPAPANSTPH"
     gene            12520..12822
                     /locus_tag="L3Q65_RS42820"
                     /old_locus_tag="L3Q65_42815"
     CDS             12520..12822
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020662214.1"
                     /locus_tag="L3Q65_RS42820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42815"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_237598164.1"
                     /transl_table=11
                     /translation="MSEEEPRVSRNDSENRYEVYADGKLAGFAEFTPKDAETVFTHTEI
                     GDEFGGRGLGKVLAKAALDDVVARGGVIVPVCPFIAGYLRKNEGYAGHVRWPGEH"
     misc_feature    12876..12891
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.61"
                     /tool="antismash"
     gene            12998..14014
                     /locus_tag="L3Q65_RS42825"
                     /old_locus_tag="L3Q65_42820"
     CDS             12998..14014
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003061625.1"
                     /locus_tag="L3Q65_RS42825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42820"
                     /product="S1 family peptidase"
                     /protein_id="WP_182892547.1"
                     /transl_table=11
                     /translation="MTSRKTLVAGFTALSAAALTAGMCVNAASASPMAFAQMQAQAITQ
                     ATQVADTLGAGNGGIYLERGKAVLNVTDAAAQEKAEAAGFATKLVKHSFTALTGAKNQM
                     DTVKNVPQTSWGIDTKTNQVVVKIYDSASQATKDKVAAAAAKLGDAARVEHRSGKLSTY
                     IADGDSINNGQFTCSLGFNVTKGGQPYMLTAGHCTNEGGTWSGGDVSGAQVVESDCPGA
                     DSGLLTRPNGTGDGAINTGQKISSAGTPTVGEQIQKMGQTTGGGSGEVTSVDESVNFDV
                     GVLNHEFGTTAHTDHGDSGGPAYDGEKGLGTLSGGDTQTSYFYPLTLELQSYGLELA"
     gene            14109..14951
                     /locus_tag="L3Q65_RS42830"
                     /old_locus_tag="L3Q65_42825"
     CDS             14109..14951
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020662212.1"
                     /locus_tag="L3Q65_RS42830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42825"
                     /product="hypothetical protein"
                     /protein_id="WP_237598165.1"
                     /transl_table=11
                     /translation="MKPNPARDLWTAIEPLHAVVYFAPEPAAAAKDVGLRGWWMGYFAG
                     RAAPLGPIGPEPVTSMFFGFAPRMVERALPDAWTFASPADVLRTRVEAVEAALTRLLGP
                     DTVDELVTLLEQAVAACRFDARPLAAAWSAVPRPDRPLARLWLATAVLREHRGDGHVLA
                     AVASGLSGLETTLTHIATGATGREQVQRARGWTDEEWSEATEKLVEHGLLDAGGLTPAG
                     AEVRRTIEETTDRLAAAPLDALGPAGVDRVLELAVPLSRRIIDRGGVPIPNPMGAKRP"
     gene            15020..15775
                     /locus_tag="L3Q65_RS42835"
                     /old_locus_tag="L3Q65_42830"
     CDS             15020..15775
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150586.1"
                     /locus_tag="L3Q65_RS42835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42830"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_237598166.1"
                     /transl_table=11
                     /translation="MLLEGKNAVVYGAGGGIGGAFARAFAEEGARVFLAGRTREKLDRV
                     ADDIRAAGGTADVAVVDALDEKSVDAHADAVVEAAGSLDISVNVISHGDVQGTPMVEMS
                     LADYEQPVVNGVRTTFLTMRAAGRHMKRQGNGVVLLFGGDGDPVRNHAVGGLQVGFSAL
                     EAMRRQLAAELGRYGVRTVTLRTGGVPETLPADFPGAEELTAELAEPTMLGRTATLADV
                     GAVAAFVASDRARTMTAATVNVSCGALVD"
     gene            complement(15962..16378)
                     /locus_tag="L3Q65_RS42840"
                     /old_locus_tag="L3Q65_42835"
     CDS             complement(15962..16378)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009073438.1"
                     /locus_tag="L3Q65_RS42840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42835"
                     /product="VOC family protein"
                     /protein_id="WP_182892544.1"
                     /transl_table=11
                     /translation="MDWTLEVVVVPVTDVDRAKAFYVDQVGFHLDHDINPGPGQRLVQL
                     TPPGSGCSIVLGKGMVPDMPPGSLKGLQLVVADVRKAREELVERGVDVGELQVYGSDPG
                     TGALEDLDNIGFIHFADPDGNSWSVQQISARAKR"
     misc_feature    complement(16400..16415)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 20.94"
                     /tool="antismash"
     gene            complement(16412..17698)
                     /locus_tag="L3Q65_RS42845"
                     /old_locus_tag="L3Q65_42840"
     CDS             complement(16412..17698)
                     /EC_number="2.7.7.65"
                     /GO_function="GO:0009975 - cyclase activity [Evidence IEA]"
                     /GO_process="GO:0009966 - regulation of signal transduction
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025: diguanylate cyclase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009073440.1"
                     /locus_tag="L3Q65_RS42845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42840"
                     /product="diguanylate cyclase"
                     /protein_id="WP_182892543.1"
                     /transl_table=11
                     /translation="MRGRVAGWFTGWRLWRLPSHVRMYVLLVNVVAVGTTLATAWLAPV
                     RQIDLIRFGVLAVCAALAIEATRHIERQREYSRAPTVAYVDTKAVWSIAAVVALPAILA
                     SAMVVLTYAVAWWRIWPRERPVLPHRWIFSCASVLCGTQAAVAVLALGMHEYPGVLADG
                     FGPGLVDLIVFVLAAGLRWAINTALVMVAIALSSPPRSFADLFSGFGDQLLEAGAIGLG
                     LVTAALLLLANPLILAGVVIALVALHRGLLLTQFQRDARTDVTTGLATKRWWRTVAERY
                     LERARANQDSVGVLLLDLDHFKAINDTYGHPTGDLVLREIALSLRDEVREQDVCGRWGG
                     EEFAIALPDIPSAEHLGHIADRIRRRIPQVVVALPDQDSVISDLTVSIGCALYPAKHLS
                     SVDDVLVAADAALYRAKQAGRNRVELASA"
     gene            18282..18452
                     /locus_tag="L3Q65_RS42850"
                     /old_locus_tag="L3Q65_42845"
     CDS             18282..18452
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="L3Q65_RS42850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="L3Q65_42845"
                     /product="hypothetical protein"
                     /protein_id="WP_182892542.1"
                     /transl_table=11
                     /translation="MQSEEVNNCHARQQLDSLNLLIADRRFGKELPSCATTTGTAEARW
                     LIAEEEGERCA"
     gene            complement(19143..20393)
                     /locus_tag="L3Q65_RS42855"
                     /old_locus_tag="L3Q65_42850"
     CDS             complement(19143..20393)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020662209.1"
                     /locus_tag="L3Q65_RS42855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42850"
                     /product="MFS transporter"
                     /protein_id="WP_182892541.1"
                     /transl_table=11
                     /translation="MTTTAPSFRSMFRIGEFRALWLAHVLSVAGDQLARVALTVLVFNR
                     TASAGWAAGTYALTYLPDLLGGALGGLADRFPRRTVLVVADVVRALLVALMAIPGMPWP
                     VAAGLLVIVQLAAGPFQAARQAVLPDMLGEEKLATGQAILSSTYQAALVIGFGAGAAVV
                     AWLGVSGALWADAVTFAVSAAALRWGLRPYPVSKATEHAPQWASLKAGCRLVARDRKLR
                     SLLAIACCCGFYVVPEGLAVPVAAQLGGTGVLGWLLVANPVGTLLGALLISRLPRARQV
                     RWLGPLAVASSLVLLPTGWTPALPVVVVVWTVSGMFSAHDLITQVQYSLAAPPEQRGQV
                     IGVAIAALRAAQGLTIAAAGALALAFAPTTVVAIAAVAGAGCAAVAGTAWARAVRADRE
                     VRPRRTPLDGATPPPAP"
     gene            20530..22029
                     /locus_tag="L3Q65_RS42860"
                     /old_locus_tag="L3Q65_42855"
     CDS             20530..22029
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009073446.1"
                     /locus_tag="L3Q65_RS42860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42855"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_182892540.1"
                     /sec_met_domain="Pkinase (E-value: 1.2e-50, bitscore:
                     171.3, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEESRQVAGRYELVELIGSGAMGMVWRGEDKILGRVVAVKELLM
                     PVNQGEDKVEEARNRAMREARIAARLQHPNAISVFNVVEHEDRPWLIMEYLPSRSLAVK
                     LREDGPLTVDEAIPFAVQLAGVLAAAHRAGIVHRDVKPGNVLLGDDGSTVKVTDFGISR
                     AVGDVTLTATGEISGTPAFLAPEVARGEEATFASDVFALGATLYMAVEGDPPFGTADNA
                     IALLYRVSSGSINPPKQAGKLEPLLLKLLELKPEDRPSMAEVVTELRELDGGVTPVATV
                     PEPPTLPEAKPPVVPTTVAVPAAGAPAAPPAGSDRRRRGMIFAGAGALLVVIAVIVTVV
                     LTRNHGEENPAANPPPASGTSAPSSAPATSSASQPSPSTQPSAPSSSSAPPSSSSAANS
                     PEAMASALRAYFSYLPGNLEAGWAMISDKFRAAHKNQTFDEYKAWWSRFSSVTANDVKV
                     TGENTLTAVITYHRAGGSPTTETHRYTMSQRNGTWQIDVES"
ORIGIN
        1 ataggaatgg ccagccagca cgaccgggcc gtcgaaagcc gcgatctccc ggcgaacctc
       61 ggcgatgtcg tccgcgagcg aggtcatcgg caggttcgcc gcacggaccc gatgtccttg
      121 ccgatgcagc gctgggatca cccccagcca caccgacccg tcgccccaag cgccgtgaac
      181 cagaacgatc tccgccatga atgcctcccc ttcgtctgaa ggcaagccaa ccaccggcgg
      241 tgcccgggga ttccccgtcc ccgcgaaaag aggaggattc cgaccgcgac cagggcccga
      301 acggcgctat ctgacaacga agccttgacc ggcgaagcgg cggccgggac gcacccggcc
      361 gccgcccgct cagctgtgcg tcagccgacc ggcgagtggt cgtaaatccg ctgctgcggt
      421 ccggagaccg cgctgagccc gttggcccac agccgctgca cccgggacgc ttcctgcgag
      481 ttcgggttgg cgttgtggca ggacgggccg gggccgccgc ccgacatcag ttcggagcac
      541 gggcccgagt agtggtccgg caagccgagc gcgtggccgg tctcgtgcgc ggtgatccgc
      601 gtgttgtcgt actggcgggc ctgggtgtag tcgatgaaga tggtgccgtg gccgtgcccg
      661 tcggtctgcg cgtacgagcc gcgcgggtcg ttgccctcga cgtaccgcag cgtggctccg
      721 gacgaacgct cgaccagctt cacgttggtc accgcgcggt tccagttcgc cgcgcccgcg
      781 ttgatcgcgg cccggaacga cggtgcgccg gacgtcgagt aatagaccgt ggcggacgcg
      841 acggcggacg gagccggagc ggcgaccgct acggcgcccg agagcggggc ggcggccagc
      901 gcgagcgcga ccgcgccgga cagcacgaac ttcctggaca taagaaagct cctggggggt
      961 ggggggagtt tgccgggttt gcgcgcgctc aacccaaagt aggcagaagc tcccgttatg
     1021 tgacccccca ttcgtacggt ccggcaaatg gtgatttccc agcactaacg acgggttgac
     1081 aacccggtca ccacggctgc atttcgtcgt cgtcctcgcc cgcggcgcgc ctgcggtgcg
     1141 gaccggacgt cggccgcggc ggttcgggag ccggcgcagg gggcggcggg gtggtgccgg
     1201 gaggcggcat cggcggacgg ctgtgcgtcg cgccgcccgg cgggggcatc gggcgtccgt
     1261 aggccgcgct tcccggcggg gtggtgctgc ccggcggagg tcccgcgtag cgggcggggg
     1321 gttcggaccg cggcggctcc ggggcgggtt ccggctcttc ctcgggctcc ggcagatacg
     1381 acttgaccac gttcatcatc tcgctgtcgc ccgcgatcgg ctcgaacgcg tcgatgacgt
     1441 cgcgcgacac ctggcgctgc gccttcccgt aggcgtccat gatcgacgcg gtcagccggg
     1501 cgccgccgtg ccgcagggcg cggtcgtcga tctcgaggtt cttgagcgcg ccgttcgggg
     1561 cgaccgaaac cgacaccagc ccgtcgcccg atttggcgcg gccctccgcg gtgctcaatg
     1621 tctcttgcag ggcagcgctt ttcgcctgca tttcgtcaat ccgccgctgg aagtcgtcca
     1681 gccacccctg atcgtccacc ggcgaacgct atcgaccgcc ctcgcccagc tggtgaacct
     1741 cggatggctg acgggctacg aaacgatcga catccgcggc gggccggagc ggtgcggggc
     1801 aacgcgagcg gtaacaatgg gcaagtgtcc gaagaagtcc aggcccgcac gcgcaaccgc
     1861 tggggcgagg gcgagcggct gcgcggggaa atcctcgccg cggccagcag gctcctgtcg
     1921 gaactcgacg gcgaggacgc gctcaccatc cgcggggtcg cgcgtgccgt cggcatcgcc
     1981 ccggccagca tctaccagca cttcagcgac cgggccgcgc tcgtcaccgg gctcgccgag
     2041 cacgagttcg gccggttgcg gctcgcgatg gaagccgccg aatcccgggt tcccgccgac
     2101 gacgcggtgg gcaggctgcg tgcgctgctg cacgcgtact gccggttcgc gatggacaac
     2161 cccggccatt accggctgat gaccgcgaac gggtcgagcc gcacgtcgcc ggacgtccgg
     2221 ccggagggtc cgacgatcga tttcgtcgac cggatctccg ccgcgttcgc ccgctgcgcc
     2281 gagtccgggg ccgagctccg ggtgcccgcc gaacgggccg gggtgatcgc gttcgtcggc
     2341 gcgcacggcc gcgtcgcgct gttccattcg tctggaaggc agccgggcga ggacgccgtg
     2401 gtgaacttcg ccgacgagct gctgtcgctc attttcgctt gagccacggg cgttttctcc
     2461 cgtttgccat cctcgtccac ggccatcccg gtgatctttg gacccgggtc tgggcaatcg
     2521 ttcaccaaat cgcctaacat gtgttcggta agtatccgaa cactcgtttg gtgacttctc
     2581 caggaggctg tgatggccga cgcccggccc gtagcgcagt tcccgatgtc gcgcgggcgc
     2641 tgcccgttcg acccgccgcc cgacctcgac cgcaagctgc gcgacgaccc ggtgtcgcgc
     2701 gtgcggatct gggacggcag cgaaccgtgg ctgatcaccc gctacgaaga cgtccgcgcg
     2761 atgctcaccg acccgcgggt gagcgccgat cccacccgcg ccggctatcc gtcgcagacg
     2821 cccggggtca aggcgcggcg cagccggttc cggtcgttca tcggcatgga cgacccggag
     2881 cacgccgccc agcgccggct gctcaccggc gatttcatgg tgaagaaggt ccagcggatg
     2941 cggccgcgga tccagcagat cgtcgacgaa ctgctcgacg agatgctggc cggcccgaaa
     3001 ctcgccgacc tcgtgcaggc gttcgcgctg ccagtgcctt cgctggtgat ctgcgagctg
     3061 ctcggcgtgc cgtacggcga tcgcgagttc ttccaccgct gcagcaagat cctggtctcg
     3121 cgggaagcga ccgccgaaca ggcgctcgcc gcgaccgagg aactgctcga ctacctcgcg
     3181 cggctggtgg agaagaaaat cgacgacccg gccgacgatg tgttcagccg cctcgcgacc
     3241 ggtcaggtcg ccaccggcgc gatgaccgtc gaggaagcgg cttcgatggg ccagctgctg
     3301 cttgtcgccg ggcacgagac cacggcgaac atgatcgcgc tcggcactgt cgcgctgctg
     3361 gagaacccgg accagctcgc cgcggtccgc gacggcgacg acgccttgct ggccaacgcg
     3421 gtcgaagagc tgctgcgcta tctgacgatc gtccactccg gacgccgccg cgtcgcgctc
     3481 gaagacctgg agatcggcgg gcagaccgtg cgcgagggcg aggggctgat cgcagccacg
     3541 gacgtcgcca accgcgatga gacgcagttc cccgagccgg acaagctcga cgtcacccgc
     3601 aaggcacgcc accacgtcgc gttcggctac ggcgtgcacc aatgcctcgg ccagccgctc
     3661 gcgcgggtcg aactgcaggt ggtctaccgg acgctctacc ggcggattcc gacgctgcgg
     3721 ctggccgcac cgctggacga gctgaagttc aagcacgaca tggtcgtcta cggggtgcac
     3781 gaacttcccg tgacctggtg aaaggagtcg cgaaatgaag gtggtcgtcg accagtcccg
     3841 ctgcgtcggg gccggacagt gcgtactcgt cgcgcccgag gtgttcgacc agcgcgacga
     3901 ggacgggatc gtggtgctgc tgcgggaaaa cccgccggag gaactgcacg cgcgggcgaa
     3961 ggaggcggcg cagctctgcc cggcgctcgc gatcgaggtg gacggctgag ccagcggccc
     4021 cggcggtcct ttatcctgta aggggaaagg ggtcgccggt ggtcgtgttc gcggggcagg
     4081 gcgacgcccg ccgttcgctg gagctgctgt ggcgcacggg cagcgaaccg cgcagcgcgc
     4141 cggggccgaa acccgcgctc agcgtggatc tcatcgtggc cgccgcgatc gagctcgcgg
     4201 acgccgaggg catgtccgca ctgtcgatgc gcgcggtcgg cgagcggctc gggcgcacgg
     4261 cgatggcgct gtacacgtac gtgccgagca agaccgagct gatcgacttg atgtgcgacc
     4321 aggcgttcgg agatctgcgc gacgaccacg acctgtccgg cggctggcgt cccgcgttgc
     4381 tcgaactggc cggcgacctg tgggaattcc atctgcgcca cccgtggctg ctgcaggtgt
     4441 cctacgcgcg tccggtgctg gggccggggg agttccggat gcaggaaacg gtgctgcggg
     4501 tgctcttcgc gaccggtctg cccgccggtc aggtgcggcg gctggtgggc gcgctgctca
     4561 acgtcgtgcg cggcgcggtg cagatcgccg ccgaatcgcg gttggcgctc aaggaaaccg
     4621 gactgtccga tgaggactgg tggcgcgcgc ggacgtccgc gctcggcgag ctggctccgg
     4681 atctggcgga gcggtacccg aatgtcgcac ggctgggcga agagagcgcg ccaccgcctg
     4741 ccggagtgtc ctatttggag catgaggcgc ggctgagctt cgatgccggg gtggcggtgc
     4801 tggcggacgg catcgaggcg gcggtctgca gggggtcgtg agtgtttatg ccggttagaa
     4861 ccggcattgc cgctcacgag gacttgcgcg cctcgatcag gtatcgagta gtcgtcgcca
     4921 cgaacggccc ctcccgcagt tcctcgtgca gttcgcgcaa ccgcggcaga tactccttca
     4981 cagtgaaccc tggcaccatc cagatcacct tgcgcaggaa gtagatcacc gctccgatgt
     5041 cgtggaactc ggtgcgcagt tcctcgaagc gcaggtccac cacttcaagc ccagcctgct
     5101 ccgcttcggc cttcgcccgg tccggatgcc ggctgtcgcg cacttccggc gtctgcggcc
     5161 cgaggaagta ctcgaccagc tcgaacacac tccacggccc gacctgctgc gacagatagc
     5221 tgccgccggg cttgaggacg cggacgatct cgtcccacca caccgtgacc ggatgcctgc
     5281 tgacgaccat ctcgaacgtg ttgtcctgaa acggaagcgg cggctcgtcc gtgtccgcga
     5341 cgacggtcgc gccccgcggt tccagcaacg cggcggcctt ctcgaggttc ggcggccacg
     5401 attcggtggc gaccgtcaac ggcggcagta ccggcacgcc cgccagcact tcgccgccgc
     5461 cggtttggat gtccacaacg gactggacgt cccgcagccg ttcgccgagc agccgctgat
     5521 atccccagga cggccgctgc tcgctggccc ggccgtccag ccaggagaaa tcccagccgt
     5581 ccaccgacac cgacgctgcc tcgtccacca gttcgtcgaa ggtgcgcatc cggtgatcgt
     5641 cacaaattcg gcgcgggcgg gccactcgat ttccgctgcg gcgccggcgg cacgggtttg
     5701 gcggcgacca ccgcggccaa cgggacgacg accagaccgc gtttggtctc gacggtgcac
     5761 gtgtcggcgt cgcgggcacg caagggaccg agggcgtcgg tgaacccgcc ctcgatccgg
     5821 tatcgcacga ccacccgcgt gcccagtggg agttccgtca gcggagtcac ttcgcgaggt
     5881 gcgcgttcag ctcgtcgtcg ctcggttcca cgaggtggct gccgtccgcg aagacgatgg
     5941 tcgggatccg gcgagcgccg tcctgcagct cgcgtacgcg agcttcggcg gccgggtcgg
     6001 cctcgacgtc cacgtagtcg tactcgacgc ccttcgcgtc gagcagcgcg cggctgcgtt
     6061 tgacgtccgg gcaccagctc gcgccgtaga cgatcgggtt gctcatgaca ctacctccga
     6121 ggggacgaca gcgggtttgc cttcggcggc accgggttcc ggatggccga ggaaggtgag
     6181 ccagtcgcgg aacacgcggt gcacggattc cgcgccgacg ggctcgccgg gtgccgggaa
     6241 ctctcgcgga tgcagcagga agccgcgctg ctgcggtccg ccgagcccgc cgtgcgagcc
     6301 gacgtgccgt tcgaacggcg aggactggtc ggaatccgcg tcgtaccggc tgttgatcat
     6361 gatgtccgcg caatgcggga aactgtcgac gcgctggacg agctcggcgg cgtacggacc
     6421 gtagccggcc agcgggtctt cgccgatcac gaccccggtg gccagccgct tcaatccgtc
     6481 gcggcccagc actaccgggc cgaactcgcg gctgcggacc agcaggaacc cgacgccgtc
     6541 gtggtcgacc agcgtcggca gcaggtccgg gtactcgcgt tcgatcgtct ccagttcgac
     6601 ccggccctcg tgttcggtga acgacaccat cgccagatgc ccggacacga cggcgaccac
     6661 cccgggagcc acccgcgtga cctgccccgg agagccagtc gcggtgcgcg gccggttctc
     6721 ggctccttcc gcgccttcga ccctggcccg caaccgtcgc gcgatcaggc cgccggtcgc
     6781 ggtcgcctcg gcgagtgccg cgttgacctg ccagctttcc gcctgccgac gctttccttg
     6841 ctcggcaacg ggttcgccgc cgcagagccg gccgacgagc gcctcgacgg tctcgccgaa
     6901 ccggtcgacg aacgcctgac cctgggtttg cccgtggtcg gacagcccga cgatgtggta
     6961 cttccgcggc gagagccgac cggcccgcag cagccgggcg aactgctggt cgatcgaccg
     7021 cagcacctcc agcgtgtcga accgttcgat gccggagtgg tgcgcgacct cgtcgtagcc
     7081 gaggaaatcg gcgtacacca ccggccgtcc ggcgagcatg tcgccgatga tcgcggacac
     7141 cacgacgtcg cgcgcgatca ccgtcgtgcc cggccgggcg agcgggtaga cgccgccgcg
     7201 cgggatccgc ggcagcacac cggcgcgccg ctgtttggcc gccgcggaca gttcgcggac
     7261 gacgtcggcg agcgcgacac cgaacgtgcg caacacgttg accgggttgg cgaagtaggc
     7321 gcgataccca gcgccgaccc ggccccggcg cttgcgcggc gtgagcaccg gcaccgaact
     7381 catggtcagg ctgacgtgcg cggcgtcgcc ggagaacagg ttgccgtggc tcgcgccgcc
     7441 gatcgacagc aggccgcggc cgtcgctgtg ccgccgttcg atctcggccg cgtcggacgg
     7501 atgcgcgcac gccatgacgt ggtcgcgatc cttttcgtac cagcggaaac cgaggatgtc
     7561 gtggttcgag ccgtgcagga tcccgcagac gctcgccccg gtctgcgaac tccagtcggt
     7621 gtgccagcgg gtgagcgaat gcgtgccctc ggacagccac ttggcgaagg tcggcatgtc
     7681 cccgtcccgc acggcgcggc ggacggtgtc gtaaccgagc ccgtcgatct gcaggaagac
     7741 cacaccgggc ggttgatcgg cgaaatcggt gcggtgcttc gctttccggc gacggcgagc
     7801 ggcgcgccgg aagaagatct cgtcctcgtc gacggccagc acgctggaga tcaccgcgcc
     7861 taccgcggac atcgcgacgg tgatgacgac cgccgtcgaa aagccgtgca gctcaacgcc
     7921 gggtacggcc tggagaatcg ccaacgccgc ggcgctgagc aggatgtacg tgccgacgcc
     7981 gagggtgaag tacgcgatcg gccacgccac ccgcaccacg agcggccaca ccaccgagac
     8041 gagcaggccg aggatcagcg cgcacaccgt cggctgccac cacgactgca tcgtgaagcc
     8101 gtcgagccac gcgtcgagca gccgcaacgc gccggtgacc gccacccaga ccagcaggac
     8161 ccgcgcgacg acccggccgc cgcgcaacaa ccggcccttc gccggagcag gtgtgctcat
     8221 cggtgtcctc ccgcctggtg ggccgcccgt ttcttggaga tcaacgtcgt caccacggtc
     8281 accagcagca ccaggacagt ggcgagcagc gtcgcgatca acggcgagtc gaagatcccg
     8341 ccgctgagga tgcccagcaa cgagtacgcc accgcccaca gcacacacgc cagcaggccg
     8401 gacggcagga acttgcgcca gggatagccg agcgtgcccg cggcgagcag caccgggatg
     8461 cgcccggcgg gcaccagacg gccgatcacc acgagctgcc agccgcgtct cgcgaactgc
     8521 tcgcggcctt tcgcgaggcg ttcggcctgc tggcggcgtt ccacgaaacg caggagaggt
     8581 tcactgccga agcgcgggac ggcgaaggtg atcacgtcgc ccaggtacgc gcccgctacc
     8641 gccagcagga tcaccagcgg gagcgagagg tggtcggtgg tcatcgcgac cgcggcggct
     8701 gccccgacga ccgcgccggt cgggacgatc gggatgacgg agccgagcag tactccgccg
     8761 aacagcgccg ggtagccgat cgctgacggg tcagtccaat tcacccgcgc tcctcgcgag
     8821 tggggagcag gacgtcggaa ccagggcggg tgtgcagcac ctcggtgtcc aggcctttgc
     8881 aacggacgtg gtgcgcgaag gtgcgcgggg gttccacgag gagctggcgc atcttggcgg
     8941 tgcgatggat gccgggaacg gcgagggtgc cccagtggac cgggaccgcc gtgcgggcct
     9001 ggagcagggc ggcggcctcg gcggctcgct ccggggtgag gtggcctggg ccgaggttcg
     9061 ggccccagcc ccagacgggg aggagggcta cgtctaccgg gcccaggtcg gccatgccgg
     9121 ggaagaggtc ggtgtcgcct gccgagtaga gccggtggtt gtttccctcc aggaggtggc
     9181 ctagggcggg gctctgggga ccgtgggtga ggcgcgggcc ccagcgatgg ccggaatgga
     9241 ctgcttcggt ggcggtgatg cggaggtcgc cggaggtgat ggtttggcct ggggagagtt
     9301 cctccacctc ggtgaagcct cgtttggtca gccaggagcc cgcgcctcgc gggacgacga
     9361 tcctcgtggc tttgccgagg agtttcaggg aggggaggtg gaggtggtcg ccgtggaggt
     9421 gggagatgag gacgatgtcc acggcggtcc aggcggagat gtccggcttc ggtgctactc
     9481 gggtcagggg gccgacccag cgggtgagga ctgggtcggt gatggcgacc tggccggcta
     9541 gttccacgcg ggtggtcgcg tggcccagga agtgaaggtt cgggctggtc acgggttcga
     9601 gtattgctgg atgtgcggtg ggatgctcgg tggagtggtg gggggcaccc tttggggctg
     9661 ctcgtcgcct ggcggcgaca tcgggccctt ggtggcgtgg ggcaccccgt tagctcattg
     9721 tgctgacggt tcgggggtgc ttgtcaaggc gggaaagatg ccttgacaag cacccccgaa
     9781 ccgcagggcg gctttgtatc ggggttgggg gagggctggg tgcctcgatg ggtgggtgca
     9841 gcggctgcgg tttgttgcgc ggcttgggtg tgtgggtgcg tgaggtgagg cggggtgcgg
     9901 ttagcgcccc aatgtggcat tgggtgcgtg ggatgcaccc aatgtggcgt tcggtgcgtc
     9961 ggacgcaccc aatgccacat tggggcgcat ccggcattcg tcagtgcggg gtggagttgg
    10021 cgggggctgg gatgtgcagg gatttggtgc cgaggccggt tgcggtcagg cggaggcggg
    10081 gtttcgcgtc gatcgggacg tatggggtgc cggtgcagcc tgggtgttcc atggctttgg
    10141 cggccggggg ttttgtcggc tcgctcggtt cggcggtgac cggtacgtcg cggactcggt
    10201 ctagttcctc gtccgtgtac cgggcgcttt cgtggtgcca gttcgcgatg ccggtcatca
    10261 ggttcttcag caggtccgcg tagccggtga gcgtgtcgcg tgcttccgcg tccaggccgt
    10321 agtcggcgaa gaggccgggc aggcctacgt ctgctgcgtg gcggaactcg gcgagtcgtg
    10381 cttctgccag gtcggcgacg atgcggatgg ctcggtcttg cccgacgtcc aggaaggacc
    10441 gcaccaccag cactgcgttg tgcaggccgc cttcgtactc gatttccttg cggtaggaga
    10501 acaaatcgtt gatcagccaa gcgtagtcgg cggcggagtc ttccagtgct tcgatgactc
    10561 ggttccggtg gatttcctta ggcacggtgc ggctgttggt cagcctgctg atgctggtca
    10621 ccaggtcgga gccgaaggtg cggcggcgca tttcgacgta atcgatgggg tcgggtatgc
    10681 ggttttggac ctggccggcc acttcccaca cccaggcgtc gatcatcgac tcgaccgtcg
    10741 cgcggaaggc ttcgcgttcg gcggggctca gcgggccggt ggtgcgttgc cacaggtccg
    10801 ccaagccggt ttccagcgcg gtttgcggtg ggggcggagg ttctccgtcg gtgggcatga
    10861 agagtttgag gcgttcggtg gtcagcctgg cggcgggcag gtcgtgggcg aggacctccg
    10921 cgtagtagtc gtcggcgtag gtgccccagg tgagccagtc gttggtgagg gacacctgct
    10981 ccgcaggcgc gtcggggcag aggcccgcgg tggccagcgg cacgtcggac gcgcgcaggc
    11041 ggacgatgtc ccagattccc tcggacagga tgcccatccg gcgaggccaa tcggcgattt
    11101 tcttgcgttc cgcggctagc tgcgggctga gtcgcaaggg gaaaggcaag ggcagggagg
    11161 gcagagtgac tgggccaagc tgttcgtgcg gttggtgcgt gaaagcccgt gtgcgttgcg
    11221 gggcggtagt ggcgatggag cggaagattc gggcggcgga ggtgccgagg ccggacgggc
    11281 cgccgagcaa ttccgggccg ccgcgggcgt ccagggcgcc tttgttcatg tagcggctgg
    11341 agcgcaggtg ccattcgtgt ccgccggatt gccagtcttg caggcctttg acgtaggcga
    11401 aggtttcggc tcgtccgggt agttgcacgc cgtgttcgtc gaatagggcg ggaacttcgg
    11461 tcagggcggt gtgttcgaat tgatgcaggc gcgacgtcag caagtcgttt accgcgtccg
    11521 cggcctcttg ggtggtgcag ctcaggaact tttcgaagac cagaacacta ttggacagtt
    11581 cgccttcgtc ctcgacttcg cgctggtagg agaagaggtc gttgcggagg tgcacggcgt
    11641 cggcgaagca gtcgcggagg acttccatgg ggcgtttcgc cgcgatttcg tcgggcacct
    11701 cggcgttcag ggagtgttcg atcaggttcg cggaccaggg tgcgccgccg accttgcggc
    11761 gcatggcgac gtattcgatg gggttcgcga cgcggttttc gttgatgttg gccagttccc
    11821 agagagattc gtcgaggagg ttgcgggtgc tttcgcggaa gcgtcgccgc caggccgctg
    11881 accggtgcgg gacggtgcgg ttccacaggt cggtcaggcc gcgttcgacg gggttttccg
    11941 gggtttcggt gatttcgcct tcggcgggca tgaaacgcgc gatccggtcg aggtaatcgc
    12001 gtgcgtgttc gatgtcgccg gtgcgtttga acagttccag gaagtggtcg tcgaagtaga
    12061 atacccagac gtaccagtcc gtgacgaggt cgagttcccg cggggcggcg tcgggatggg
    12121 tgtaggagca caacagggcg taatcgtggg agtcgaggtc gtgctcgttc cagatgacgg
    12181 tgccgtgctg gggcacgtcg accatgtcca tcgtgtacgc ccatgccttg ctgtgcttcc
    12241 gcgcgccgtc caggtgcggg ttcagccggg ccgggtacga cagatagaac tcgggcagga
    12301 cgaacggctg cacgcgggct cccctcgcgg tcgcgggtac cgacaccacg aggcaaacag
    12361 accgcaccgg cgcggcggaa ggcccgcgcg ggcacgccac tcccgcggtc gtggcgcatc
    12421 gctcatgcgg ccgagggcga gggctgtttt gatgggcgct gagtacatcc gcgtcgctcg
    12481 atggtggaga tcgaggcgcc gaccaacgag gagccgaaga tgagcgagga agagccccgg
    12541 gtctcccgca acgacagcga aaaccgctac gaagtgtatg cggacggcaa actcgccggc
    12601 ttcgccgagt tcacgccgaa ggacgccgaa accgttttca cgcacacgga aatcggcgac
    12661 gagttcggcg gtcgcgggct cggcaaggtg ctggcgaagg ccgcgctgga cgacgtcgtc
    12721 gcgcggggcg gcgtgatcgt tccggtgtgc ccgttcatcg ccgggtacct gcgcaagaac
    12781 gagggctacg ccgggcacgt ccgctggcca ggagagcact gacgcaggtc agcagcgccg
    12841 ttcggggtat tccaggtggc ccgaacggcg cagcggtgtc cgattggtcc gcattttttg
    12901 gttattaacc aaccttcgtc ggtttcgcgt tggttgccgg gcaacaaaag tgtggggcgt
    12961 cccaccggtc ggtttcagcc cacctggagg aagatccatg acttcccgga agacgctcgt
    13021 cgcgggattc accgcactgt cggccgcggc cttgaccgcg ggcatgtgcg tgaacgccgc
    13081 ctcggcaagc ccgatggcgt tcgcccagat gcaggcacag gcgatcaccc aggcgacgca
    13141 ggtcgccgac acgctcggcg ccggaaacgg cggcatctac ctcgaacgcg gcaaggcggt
    13201 gctgaacgtc accgacgccg cggcgcagga gaaggccgag gccgcgggct tcgcgacgaa
    13261 gctcgtcaag cacagcttca ccgcgctcac cggcgcgaag aaccagatgg acacagtcaa
    13321 gaacgtgccg cagacgtcgt ggggcatcga caccaagacc aaccaggtcg tggtgaagat
    13381 ctacgactcg gcgtcccagg ccacgaagga caaggtcgcg gcggccgcgg cgaagctggg
    13441 cgacgcggcg cgcgtcgagc accgctccgg caagctgtcc acctatatcg cggacggcga
    13501 ctcgatcaac aacggccagt tcacctgctc gctcggcttc aacgtgacca agggcggcca
    13561 gccgtacatg ctgaccgcgg gccactgcac caacgagggc ggcacctggt ccggcggcga
    13621 cgtttccgga gcccaggtcg tcgaaagcga ctgccccgga gccgactccg gcctgctgac
    13681 ccgcccgaac ggcaccggtg acggcgcgat caacaccggc cagaagatca gcagcgcggg
    13741 cactccgacc gtcggcgagc agatccagaa gatgggccag acgaccggcg gcggcagcgg
    13801 cgaggtcacc tcggtggacg agtcggtcaa cttcgacgtc ggcgtcctga accacgagtt
    13861 cggcaccacc gcccacaccg accacggcga ctcgggcggc ccggcgtacg acggcgagaa
    13921 gggcctcggc accctctccg gcggtgacac ccagaccagc tacttctacc cgctgaccct
    13981 ggaactgcag tcctacggcc tcgagctcgc ctgaggcttt cagctccacg gcccgccgtc
    14041 ccgctttcgg ggcggcgggc ttcttcgcgc ggcggttctt gtcgtacccg gggcttagag
    14101 ttccccgcat gaagccgaac ccggcccgag acctctggac agccatagaa cccctccacg
    14161 cagtcgtcta cttcgccccg gaacccgccg cggcggcgaa ggacgtcggc ctgcgcggct
    14221 ggtggatggg ctacttcgcg ggccgggcgg cgccactcgg cccgatcgga ccggaaccgg
    14281 tcacgtcgat gttcttcggg ttcgcgccgc ggatggtcga gcgagcgctg ccggacgcgt
    14341 ggacgttcgc ttctcccgcc gacgtgctgc gcacccgggt ggaagcggtc gaagcggcac
    14401 tgacgcggct gctcggtccg gacactgtgg acgaactggt gacgctgctg gaacaagccg
    14461 tcgcagcctg ccgattcgac gcccgtccgc tcgccgcggc ctggtccgcg gtgcctcgtc
    14521 ccgaccggcc gctggcccgg ttgtggctgg cgactgctgt cctgcgcgaa catcgcggtg
    14581 acggccacgt cctggccgcc gtcgcctccg ggctgagcgg gctggaaacc acccttacgc
    14641 acatcgccac cggagccacc ggtcgcgagc aagtccagcg cgcccgaggg tggactgacg
    14701 aagaatggtc tgaggcaacg gaaaaactgg tcgagcacgg cctgctcgac gctggcggat
    14761 tgaccccagc aggcgcggaa gtccgccgca ccatcgaaga aaccaccgac cggctggccg
    14821 ccgccccgct cgacgcactg ggcccggcag gcgtcgaccg ggtgctggaa ctggcagtcc
    14881 cgctcagccg gcggatcatc gacaggggag gtgttcccat ccccaatccg atgggcgcga
    14941 aacgtccctg agcacgatgt cgattccccg gttccccgct cgacgcactg gtgacaggca
    15001 cgagaaggga gcccggaaga tgctgctcga aggcaaaaac gcggtcgtgt acggcgccgg
    15061 cggaggaatc ggcggcgcgt tcgctcgagc gttcgccgag gaaggcgcgc gagtcttcct
    15121 cgccggacgc acccgcgaga agctggaccg agtcgccgac gacatccgcg ctgctggcgg
    15181 caccgccgac gtcgccgtag tcgacgcgct cgacgagaag tccgtcgacg cccatgccga
    15241 cgcggtcgtc gaagccgcgg gcagtctcga catctcggtg aacgtgatca gccacggcga
    15301 cgtccagggg acccccatgg tcgagatgtc gttggccgac tacgaacaac cggtggtcaa
    15361 cggcgtgcgc accacattcc tcaccatgcg tgcagcgggc cggcacatga aacgccaagg
    15421 caacggcgtc gtcctcctct tcggcggcga cggcgacccg gtgcgcaacc acgcggtcgg
    15481 cggcctgcaa gtgggcttct ccgcgctgga agcgatgcgc cggcaactcg ccgccgaact
    15541 cggccggtac ggcgtgcgca ccgtgaccct ccggaccggc ggtgtcccgg aaacgctccc
    15601 cgcggatttc cccggagccg aggaactcac cgcggaactc gccgagccga ccatgctcgg
    15661 ccgcaccgcg acgctggccg atgtcggtgc ggtagcggcg tttgtcgcgt ccgaccgagc
    15721 ccgcacgatg accgccgcga cggtgaacgt cagctgtggc gcgctggtgg actaggcgga
    15781 cgagtacaaa cgcgacagac ggagacgacg gacctcggcc cgggagggcg ggtgctgcgg
    15841 attcggccga atgcgaaggc tcggtcttga acagcatcca ggcgcccgcc cctgtcgccg
    15901 cgccacgaac cacgagctac tgcggtacga gaaccagttg ccgcagcgcg gcgactccgg
    15961 gctacctctt ggcgcgggcg gagatctgct ggactgacca gctgttgccg tcgggatcgg
    16021 cgaagtggat gaacccgatg ttgtcgaggt cttccagcgc cccggtgccc ggatccgagc
    16081 cgtagacctg gagctcgccg acgtcgacgc cgcgttcgac cagttcctcg cgggccttcc
    16141 gcacatcggc gacgaccagt tgcagaccct tcagcgaccc cggcggcatg tccgggacca
    16201 tgcccttgcc caggacgatc gaacagcccg atcccggcgg cgtcagctgc acgaggcgct
    16261 ggcccggtcc cgggttgatg tcgtggtcga ggtggaagcc gacctggtcc acgtagaacg
    16321 ctttcgcccg gtccacatcg gtgaccggga cgacgacgac ctcgagagtc cagtccatga
    16381 gacgagttct agcgggggcc cgagcaggcg gtcaagcgct cgccagctcc acccggttcc
    16441 ggcctgcctg cttggcccgg tagagcgcgg cgtcggcggc caccagcacg tcgtcgacgc
    16501 tggagaggtg cttcgccggg tacagcgcgc agccgatcga gacggtcagg tcgctgatca
    16561 ccgaatcctg atccggcagc gcgacgacca cctgcgggat ccgccgccgg atgcggtcgg
    16621 cgatgtggcc gaggtgctcg gcgctcggga tgtccggcag cgcgatcgcg aactcctcgc
    16681 cgccccagcg gccgcacacg tcctgctcgc ggacttcgtc gcgcagcgac agcgcgatct
    16741 cgcgcagcac caggtcgccg gtggggtggc cgtaggtgtc gttgatcgcc ttgaaatggt
    16801 cgaggtcgag cagcagcacg ccgacgctgt cctggttcgc ccgcgcgcgt tcgaggtagc
    16861 gctcggcgac cgtgcgccac cagcgtttgg tggccagccc ggtggtgacg tcggtgcgcg
    16921 cgtcgcgctg gaactgggtg agcagcagcc cgcggtgcag tgccacgagc gcgatcacga
    16981 cgcccgccag gatcagcggg ttggcgagca gcaggagcgc cgcggtgacc aggccgaggc
    17041 cgatcgcgcc cgcttcgaga agctggtcgc cgaagccgga gaacaggtcg gcgaacgacc
    17101 gcggcgggct cgacagcgcg atcgcgacca tgacgagcgc ggtgttgatc gcccagcgca
    17161 gtccggcggc gagcacgaag acgatcaggt cgaccaggcc gggcccgaag ccgtcggcga
    17221 gcaccccggg gtattcgtgc atcccgagcg cgagtaccgc gacggcggct tgcgttccgc
    17281 acaggacgga cgcgcaggag aagatccagc ggtgcggcag aaccggccgt tcacgcggcc
    17341 agatccgcca ccacgcgacg gcgtaggtga gcacgaccat cgccgaggcg aggatcgcgg
    17401 gcaacgccac cacggcggcg atgctccaca cggccttggt gtcgacgtac gcgactgtgg
    17461 gcgcgcggct gtattcgcgc tgccgttcga tgtgccgggt cgcctcgatc gccagcgccg
    17521 cgcacacggc gagaacccca aagcggatca ggtcgatctg acgcactggc gcgagccacg
    17581 cggtggcgag ggtggtgccc actgccacga cgttcaccag cagcacgtac atgcggacgt
    17641 gagagggcaa ccgccatagg cgccagcctg tgaaccaccc ggcaactcgt ccgcgcactc
    17701 ttcacctcac ccgattggct tctacggtaa acgacgaggc gcgttgtgtg ctgcctgtcg
    17761 tccggactct gggaagcacc ggggcgattt cgcccggaca gcccagcgcc agacggccgg
    17821 cgaggggagg tggccactgt gagtagcggc cgactgctcc gaatccgggc cggaccaggg
    17881 gatccacgag ggtccctttt ggacccccat ggccactttc ggtgaccagc ctaccggcga
    17941 tgacgtgcga aaaccgccga aggcgcgact ctgaaacgga ggtgacgaca gtgcgcgaca
    18001 acaactggac ggctcttcgg tgacctcggt ctccctcacg gtctcgactc gaggtcgaga
    18061 cttcggtctt cgcagatgag aggaggtgcc cacagtgcgg gacaacaact ggtgaatggc
    18121 gccgagcagg gaatccggga tgcggaaagg aggcggcgag atgcgcgaca acaactggac
    18181 ccgctgagga ccgtcggccg atcggagtcg ttcgaaaagg aggtggccgc ggtgcgtgac
    18241 aacaactggg cccgctgaaa cggctgaaac cacggaacga aatgcagtcg gaggaggtga
    18301 acaactgcca tgcgcgacaa caactggact cgctgaacct gctgatcgcc gaccgtcgat
    18361 tcgggaagga gctgccgtcg tgcgcgacaa caactggaac cgctgaagcc cgctggctga
    18421 tcgctgagga ggaaggagag cgctgtgcgt gacaacaact ggactcggtg agttccgctg
    18481 attactggcc gtcgagctgc gaagggagtc gccgcgatgc gcgacaacaa ctggacccgc
    18541 tgagccccgc gatcactgac cgccgacatc gcgaaaggag tcgttgcagt gcgcgacaac
    18601 aactgggctc gctgagcctc gccgatcgcc gaccgccgag ccatgaaggg agtcgccgcg
    18661 atgcgcgaca acaactggac ccactgaacc ccggcaacca ccgcccgtcg agccacgaaa
    18721 ggaaccgtcc cgtgcgcgac aacaactgga cccgctgagc ccgctgacca ccgcccgcca
    18781 actcgtgaag ggagccgctg ccgcgatgcg tgacaacaac tgggctcgct gagtcccgcc
    18841 gatcaccgcc cgtcgagccg tgaaaggagc tgccgcgatg cgtgacaaca actggacccg
    18901 ctgagccccg ccaaccaccg cacatcaagc cgcgaaggga acgccgccat gcgtgacaac
    18961 aactgggctc gctgagcccc gccgtccatc acccaccgag ccatgaaggg agccccgcca
    19021 tgcgtgacaa caactggacc cgctgaccga cccccagccc gccccacgag gaggtgagag
    19081 ggcatgcgtg acaacaactg gacgtgaccg aagccagtcc cgcggcgcac ccgtcccgcg
    19141 gattacggcg cgggaggtgg ggtggccccg tcgaggggag ttcggcgggg ccgcacctcg
    19201 cggtcggctc gcaccgcccg cgcccatgcg gtcccggcca ccgcggcgca ccctgccccg
    19261 gctacggcgg cgatcgcgac caccgtcgtc ggcgcgaagg ccagcgccag cgcgcccgcg
    19321 gccgcgatcg tcaggccctg cgccgctcgc aacgccgcga tcgcgacccc gatcacctgg
    19381 ccgcgttgtt ccggcggcgc ggcgaggctg tactgcacct gggtgatcaa gtcgtgcgcg
    19441 gagaacatcc cggacactgt ccagaccacg acgaccaccg gcaacgcggg cgtccagccg
    19501 gtcggcagca gcacgaggct gctcgccacc gcgagcggac ccagccaccg cacctgccgc
    19561 gctcgcggca accggctgat cagcaacgcg ccgagcagcg tcccgaccgg gttcgccacc
    19621 agcagccagc cgagcacgcc cgtgccgccg agttgcgcgg ccactggcac cgccaaaccc
    19681 tccggcacga cgtaaaaccc gcagcagcac gcgatcgcca gcagcgaccg cagtttccgg
    19741 tcccgcgcga ccaatcggca cccggccttc aacgacgccc actgcggcgc gtgttcggtc
    19801 gccttcgaga ccgggtacgg ccgcaaaccc cagcgcagcg cggctgccga caccgcgaac
    19861 gtcaccgcgt ccgcccacag cgcgcccgaa accccgagcc acgcgaccac cgcggcaccc
    19921 gcgccgaagc cgatcaccag cgccgcctgg tacgtcgagg agagaatcgc ttgtccggtc
    19981 gccagtttct cctcgcccag catgtccgga aggaccgctt gccgagccgc ctgaaacggg
    20041 cctgccgcga gttgcacgat cacgagcagt cccgcggcga ccggccaagg catgccggga
    20101 atcgccatca acgcgaccag cagtgcgcgc acgacatcgg cgaccacgag cacggtgcgg
    20161 cgcgggaacc ggtcggcgag cccgccgagt gcaccaccga gcaggtccgg caaataggtg
    20221 agcgcatacg tcccagcggc ccagcccgcg gaggccgttc ggttgaacac caacacagtc
    20281 agcgcgactc gtgctagttg gtcacctgcc accgacagca cgtgcgcgag ccaaagcgca
    20341 cgaaattcgc ctatccggaa catgctccgg aaagacggcg ctgtcgtggt catgtgctca
    20401 ccctgtcgtg actcggccac ccggagcaac ccgggcctgg cgcgggtggg tcgcggatcc
    20461 ggctccggcc gtccgtggaa aactgggtga tcgccgtccg tggatgatgt cgcaccgaag
    20521 ggttttccgt tgaccgagga gagccggcag gtcgccggtc gctacgagct cgtcgaactg
    20581 atcggcagcg gcgcgatggg gatggtctgg cgcggggagg acaagatcct cggccgcgtc
    20641 gtcgcggtga aggaactcct catgcccgtg aaccagggcg aggacaaggt cgaggaagcc
    20701 cgcaaccgcg ccatgcgcga ggcccgcatc gccgcccggc tgcagcatcc gaacgccatc
    20761 tcggtgttca acgtggtcga gcacgaggac cggccatggc tgatcatgga gtacctgccc
    20821 tcgcgcagcc tcgcggtgaa actgcgcgag gacggcccgc tgaccgtcga cgaggcgatc
    20881 ccgttcgcgg tgcagctggc cggcgtgctc gccgccgcgc accgggcggg catcgtgcac
    20941 cgcgacgtca aaccgggcaa cgtcctgctc ggcgacgacg gcagcacggt caaggtgacc
    21001 gacttcggca tttcgcgcgc ggtcggcgac gtcacgctca ccgcgaccgg cgaaatctcc
    21061 ggcacgcccg cgttcctcgc gcccgaggtc gcccgcggcg aggaggcgac gttcgcctcc
    21121 gacgtgttcg ccctcggcgc gacgctgtac atggcggtgg agggcgatcc gccgttcggt
    21181 accgcggaca acgcgatcgc cttgctgtac cgggtttcca gcggttcgat caacccgccg
    21241 aagcaggccg ggaagctgga gccgctgctg ctgaagctgc tggagctcaa accggaggac
    21301 cggccgtcga tggccgaggt cgtcacggaa ctgcgcgaac tcgacggcgg cgtcaccccg
    21361 gtcgcgaccg tcccggaacc gccgacgctg ccggaagcca aaccgccggt cgtgcccacg
    21421 acggtcgcgg ttccggccgc gggtgccccc gccgcgccgc ccgcgggctc ggaccgaaga
    21481 cgccgcggga tgatcttcgc cggggcgggc gcgctgctcg tcgtgatcgc cgtgatcgtc
    21541 accgtcgtcc tcacccgcaa ccacggggag gaaaacccgg ccgcgaaccc gccgcctgct
    21601 tctggaactt ccgcaccttc cagcgctccg gcgacttcat ccgcgtcgca gccttcgccg
    21661 tcgacgcagc cgtccgctcc gtcttcgtcg agtgctcctc cgtcttccag ttccgcggcg
    21721 aactctccgg aggcgatggc ttccgcgctg cgcgcttact tctcgtacct gccgggcaat
    21781 ctggaagccg gctgggcgat gatcagcgac aagttccgcg ccgcgcacaa aaatcagact
    21841 ttcgacgagt acaaggcgtg gtggagccgg ttcagttcgg tgaccgcgaa cgatgtgaag
    21901 gtcaccggcg agaacacgct caccgcggtg atcacctatc accgcgccgg cggcagcccg
    21961 acgaccgaga cgcaccgcta cacaatgtcg cagcgcaacg gcacctggca gatcgacgtg
    22021 gagagctagc tctcgagcag cagcgcgatc gcggcggcgg tgtcgcggtc cgggccgact
    22081 cgcacggtgc gcaatccggc ggaccgtgcg ggttcgacgt cctcgccgac gagccaggcg
    22141 tcgtccaggg tggtttcgca gcgttcggcg gcgagcgcga acagcttcgg gtccgatgtg
    22201 gacagtccgt ccggcccggc gagcacccag ccgtccacga gcccggcgat tccggtgcac
    22261 agcagcgtgg acagctgcgg ttcgccctcg ccgaggacgc cgatccgcca gcc
//
