LOCUS       NZ_CP091381            20678 bp    DNA     circular CON 18-AUG-2024
DEFINITION  Amycolatopsis sp. FU40 chromosome, complete genome.
ACCESSION   NZ_CP091381
VERSION     NZ_CP091381.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. FU40
  ORGANISM  Amycolatopsis sp. FU40
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 9944196)
  AUTHORS   Reisman,B.J. and Bachmann,B.O.
  TITLE     Biosynthesis of Apoptolidin Family Glycomacrolides
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9944196)
  AUTHORS   Reisman,B.J. and Bachmann,B.O.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-2022) Chemistry, Vanderbilt University, 1234
            Stevenson Center Drive; Room 7330, Nashville, TN 37235, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 23-JAN-2022
            Assembly Method                   :: Flye v. 2.9
            Assembly Name                     :: NFU40_flye_2.9
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 47.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_021903635.1-RS_2024_08_18
            Annotation Date                   :: 08/18/2024 04:30:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,491
            CDSs (total)                      :: 9,417
            Genes (coding)                    :: 9,360
            CDSs (with protein)               :: 9,360
            Genes (RNA)                       :: 74
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 7 of 57
            Pseudo Genes (incomplete)         :: 50 of 57
            Pseudo Genes (internal stop)      :: 5 of 57
            Pseudo Genes (multiple problems)  :: 5 of 57
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:13:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8954399
            Orig. end                         :: 8975077
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP091381.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Brian O. Bachmann,
            Vanderbilt University.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20678
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="CDPS"
                     /region_number="36"
                     /rules="CDPS"
                     /tool="antismash"
     cand_cluster    1..20678
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="CDPS"
                     /kind="single"
                     /product="CDPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20678
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="False"
                     /core_location="[10000:10678](-)"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10678)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
     misc_feature    complement(749..764)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 22.31"
                     /tool="antismash"
     misc_feature    complement(975..988)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.32"
                     /tool="antismash"
     gene            975..1664
                     /gene="ftsE"
                     /locus_tag="L3Q65_RS42475"
                     /old_locus_tag="L3Q65_42470"
     CDS             975..1664
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0000910 - cytokinesis [Evidence IEA]"
                     /codon_start=1
                     /gene="ftsE"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007023811.1"
                     /locus_tag="L3Q65_RS42475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42470"
                     /product="cell division ATP-binding protein FtsE"
                     /protein_id="WP_009073292.1"
                     /transl_table=11
                     /translation="MIRLEEVSKVYKTSTRPALERVSVEIDKGEFVFLIGPSGSGKSTF
                     LRLLLREEVPSKGRVMVSNFDVAKLARRRVPRLRQTIGCVFQDFRLLANKTVAENVAFA
                     LEVIGKPRPTIRKVVPEVLELVGLDGKADRLPNELSGGEQQRVAIARAFVNRPLVLLAD
                     EPTGNLDPDTSQDIMLLLERINRTGTTVLMATHDHSIVDSMRRRVVELQLGRVIRDDAR
                     GVYGIGR"
     gene            1716..2609
                     /gene="ftsX"
                     /locus_tag="L3Q65_RS42480"
                     /old_locus_tag="L3Q65_42475"
     CDS             1716..2609
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene="ftsX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020643739.1"
                     /locus_tag="L3Q65_RS42480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42475"
                     /product="permease-like cell division protein FtsX"
                     /protein_id="WP_009073294.1"
                     /transl_table=11
                     /translation="MRASFVFSEVVTGLRRNVTMTIAMILTTAVSLAMLGGGLLAVRTI
                     DKMKANFLAEVEVSVALVDDVSANDKNCTQALCNGLRQSLQNNPGVESVVYENRDQAYD
                     RFKKIFASQPELLELTGPEALPASLQVKLKDPDRSDAIIKQYTGQPGVKKVDDQKKFLD
                     RVFNVFNGVRNIAFVMALIMAVAALLLIANTIQVSAFTRRTEVGIMRLVGATRWYTQLP
                     FLLEAVVAGTVGAVLGVVFLLLTKLSFLDTVFTGEVFPQITTLEVLFPVAPILLAVSIV
                     ISAITGYVTLRLYVRH"
     gene            2662..3144
                     /gene="smpB"
                     /locus_tag="L3Q65_RS42485"
                     /old_locus_tag="L3Q65_42480"
     CDS             2662..3144
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene="smpB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020662276.1"
                     /locus_tag="L3Q65_RS42485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42480"
                     /product="SsrA-binding protein SmpB"
                     /protein_id="WP_067593092.1"
                     /transl_table=11
                     /translation="MPKERGQKVIASNRKARHDYSILDTYEAGMVLQGTEVKSLRAGKA
                     SLVDAFATVDDGEVWLRNVHIPEYTQGTWTNHMPRRTRKLLLHRREIERLIGKTKESGL
                     SLVPLSMYFKDGKVKVEIALARGKKAYDKRQSLAKRDAQKDISRAMGRALKGRFTE"
     gene            3141..4037
                     /locus_tag="L3Q65_RS42490"
                     /old_locus_tag="L3Q65_42485"
     CDS             3141..4037
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005168414.1"
                     /locus_tag="L3Q65_RS42490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42485"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_237598140.1"
                     /transl_table=11
                     /translation="MTAGPATDADVPGWIAGLGLDGIVDLHVHFLPKPVLDKVWAYFDR
                     AEQHYGTPWPIHYRTPEPERIDTLRALGVKAFAPLVYPHKPGMAEWLTSWVLDFADQVP
                     EAVPTGTFYPEPSAASSVDSALRAGARCFKAHVQVGAYDPRDELLDPVWGSLSEAGVPV
                     VIHCGHGPLRGDFTGLEVFEEVLQRHPRLTAVLAHAAMPQFTTAFELMARYPRVHLDTT
                     MVGVPFAEAMSPLPPDWTVRLAEVADRVVLGTDFPNIPYSYATQLRAIAGWAADNRLGE
                     PFLRAVLHDTPAKLLSV"
     gene            complement(4027..5328)
                     /locus_tag="L3Q65_RS42495"
                     /old_locus_tag="L3Q65_42490"
     CDS             complement(4027..5328)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020662274.1"
                     /locus_tag="L3Q65_RS42495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42490"
                     /product="acyltransferase"
                     /protein_id="WP_237598141.1"
                     /transl_table=11
                     /translation="MTTSQLQTRGARATRDKFLDVVRAGAILAVVAQHWTMPVLSFSGT
                     TLATGNALATPGWWIITWASQVMPLVFFAGGAANLISLRRAESTRAWFAGRVRRLLVPV
                     LPLMAVWLVVPDLLQGMGVPPQPVQVASAIAAQLLWFLSVYLLTVLLTPLMVAAHRRWG
                     LAVPAVLAGLGVLVDVARFSDLGMIGYANAVIVWVAVHQLGFHYVEGRLGALSRRAALA
                     VSAAGFGVTALLVAFGPYPASMIGMPGAPVSNMSPPTVLLLFLALGQIGFLLAFREKLV
                     SLPRVTAALSWLSPRFMSVYLWHMPALVVVSGVTVFGLGYSTPTPGSSMWFLMAPAWFA
                     VCGAVLLGLLRLFQRFEMQPDGLVVTARTPQLVLAGLLASGGLLGLAAHGFAPLNDNLL
                     TGPLPWVALVAAGYALAGRQVSMPRSRALVAVKR"
     gene            complement(5474..5692)
                     /locus_tag="L3Q65_RS42500"
                     /old_locus_tag="L3Q65_42495"
     CDS             complement(5474..5692)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009073301.1"
                     /locus_tag="L3Q65_RS42500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42495"
                     /product="hypothetical protein"
                     /protein_id="WP_009073301.1"
                     /transl_table=11
                     /translation="MSDRSVRFFGGPLDGRVQELADEEPVPGTVVRHIHLHGGPKIETR
                     YELGLTENGWAYRVQAHESEPEPDTLS"
     gene            complement(5778..6419)
                     /locus_tag="L3Q65_RS42505"
                     /old_locus_tag="L3Q65_42500"
     CDS             complement(5778..6419)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016331648.1"
                     /locus_tag="L3Q65_RS42505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42500"
                     /product="response regulator transcription factor"
                     /protein_id="WP_009073303.1"
                     /transl_table=11
                     /translation="MRVVIAEDAVLLRAGVTRLLADEGIETVAAVDNGDDLLGAITEHR
                     PDLAIVDVRMPPTFTDEGLRAALAARKEIAGLPVLVLSQYVEESYAVELLSGGAGGVGY
                     LLKERVADVDEFLDAVRRVADGGTAIDPDVIAQLMARGRRNPLDSLTARESEVLGLMAQ
                     GLSNNAIANSLVVSHGAVEKHIGNIFSKLGLEASSEEHRRVRAVLTYLGR"
     gene            complement(6477..7610)
                     /locus_tag="L3Q65_RS42510"
                     /old_locus_tag="L3Q65_42505"
     CDS             complement(6477..7610)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009073305.1"
                     /locus_tag="L3Q65_RS42510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42505"
                     /product="sensor histidine kinase"
                     /protein_id="WP_237598142.1"
                     /transl_table=11
                     /translation="MTAQDPPPEHPRPHPARTIAYMIPSFVLRLLQFILIVVGATAGTA
                     TLIIWIGFPILLAVTGFIRWSGDLERRWARRMLGTPLGPVERLPLDGQPMTRRWLTRLS
                     DPTTWRDLAYLMVAFPLAIVELPIALASIVLLPMAIWVTPWLGWLHGNLALSLLGPNRT
                     KKLEKKAEHLQASRARGVDAAEAERRRIERDLHDGAQQRLVAVAMSLGRAKSKFDNDPN
                     AVRDLIDEAHSDAKLAVSELRDLARGIYPAVLGDRGLDAALSAQAAKSPIPVDVHVNVE
                     PRPPAAVETTAYFIVGETLTNIAKHSGATEAMVKVWRSETHVITEITDNGHGGAEVRPG
                     SGLAGLADRAATIDGVITVVSPVGGPTVIRADLPCQW"
     gene            complement(7607..8299)
                     /locus_tag="L3Q65_RS42515"
                     /old_locus_tag="L3Q65_42510"
     CDS             complement(7607..8299)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009073307.1"
                     /locus_tag="L3Q65_RS42515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42510"
                     /product="sensor domain-containing protein"
                     /protein_id="WP_237598143.1"
                     /transl_table=11
                     /translation="MVTVPAGRTFGRRTPPLGGALAYLLLNLPVGILSFTLIVTLGSAG
                     LGTLIVWLGVPLLALLVLFARTAGRVERGRVFALLDVYIDDPYLPLPPSGQKQRWLTRL
                     KDPATWRDLSYLFLLFPLGLVEFVLVVTVWAVSLGLVGLPVYYRFLPDGVYAFPSYDVQ
                     WFVVDSTVTALPWAALGVLFAAIAVALTKGLAALHAAFAAGFLRPTVAQRRRMERSWNE
                     IDGITVAG"
     tmRNA           8465..8839
                     /db_xref="RFAM:RF00023"
                     /gene="ssrA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00023"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /locus_tag="L3Q65_RS42520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /old_locus_tag="L3Q65_42515"
                     /product="transfer-messenger RNA"
     gene            8465..8839
                     /gene="ssrA"
                     /locus_tag="L3Q65_RS42520"
                     /old_locus_tag="L3Q65_42515"
     misc_feature    8896..8911
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 24.29"
                     /tool="antismash"
     gene            complement(9246..9986)
                     /locus_tag="L3Q65_RS42525"
                     /old_locus_tag="L3Q65_42520"
     CDS             complement(9246..9986)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (44-153). E-value: 5.2e-10. Score:
                     29.9. Matches aSDomain: nrpspksdomains_L3Q65_RS42525_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024880.4"
                     /locus_tag="L3Q65_RS42525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42520"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_182895330.1"
                     /transl_table=11
                     /translation="MTESVDQYDQVATAFADVEAIISFVRENLEWPSFKDLLGDLRGLR
                     VLDVGCGEGSFTRRIKQLGAAQVVGTDLSPGMIALAQQAEARNPQGITYEVQDLAAMPP
                     QGEFDVVTAIHVLHYADTRKTMQTMANTMHANLKPGGKLAILSANANSSEESETAAGFR
                     TYRPANPKEGDKFKVAVLTTPPTEIEVHHWPTETIVEVLETAGFTNVSWDLVKPSETVA
                     PADQDRAARCAKNPTSLTITATKP"
     aSDomain        complement(9528..9854)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_L3Q65_RS42525_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="5.20E-10"
                     /label="L3Q65_RS42525_oMT.1"
                     /locus_tag="L3Q65_RS42525"
                     /protein_end="153"
                     /protein_start="44"
                     /score="29.9"
                     /tool="antismash"
                     /translation="RVLDVGCGEGSFTRRIKQLGAAQVVGTDLSPGMIALAQQAEARNP
                     QGITYEVQDLAAMPPQGEFDVVTAIHVLHYADTRKTMQTMANTMHANLKPGGKLAILSA
                     NANSS"
     gene            complement(10001..10678)
                     /locus_tag="L3Q65_RS42530"
                     /old_locus_tag="L3Q65_42525"
     CDS             complement(10001..10678)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) CDPS:
                     CDPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009073312.1"
                     /locus_tag="L3Q65_RS42530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42525"
                     /product="tRNA-dependent cyclodipeptide synthase"
                     /protein_id="WP_182895329.1"
                     /sec_met_domain="CDPS (E-value: 3.8e-71, bitscore: 238.3,
                     seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISNGFSVEPLTTSCREVWESRRHAVFGVSPGNSYFNVDRLRSTL
                     DWLQTEFKQIDVVIPDSALKHTFTALGYDEAKAAKKARSETNVLRNRVLRAWTDLGGPR
                     PADGLHRMSELSENLTYTEVLEHCTHLTAADPTLASASTEMTKEVLAAKGLTGDATPAQ
                     IAEAKNYLIAELPFFVSSCRIFEVDASLNFYHQPLPLANVIFSDAAALKPEPGQGYATI
                     RPA"
     gene            complement(10675..12282)
                     /locus_tag="L3Q65_RS42535"
                     /old_locus_tag="L3Q65_42530"
     CDS             complement(10675..12282)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (48-432). E-value: 1.3e-54.
                     Score: 177.2. Matches aSDomain:
                     nrpspksdomains_L3Q65_RS42535_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015803346.1"
                     /locus_tag="L3Q65_RS42535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42530"
                     /product="class I adenylate-forming enzyme family protein"
                     /protein_id="WP_237598144.1"
                     /sec_met_domain="AMP-binding (E-value: 7.9e-50, bitscore:
                     168.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPNWAFSLGELFDHRSSSGKPMTFHLSRPLDIDREDRSSLDLPA
                     IAALVRDSAGVLSKAGVKPGDRVVVYKANHFDCILLAAAISRLGAVAVILSGLLGKEAA
                     QSLIRRVEPSAVVTDAERIERAEITPEAFPDLAGKIFSVNGDSPHAQTYADLKAEPHLH
                     PVPRRDDELLMLTHTSGTTGIPKLIIFPPATIQKQMARLECRHFPPLTFRRNDVVAMFT
                     PYVHARAFTWIYSVLTLSPATVLAMDDSSPDVVDRVFRRYQPTFMEALPIDYSAMAPLI
                     RTGANNPFARIRLFAGNFDAIRWPVIRRFLNASRHPFPLWRDGYGQSETGGMGMTVLSR
                     RSANRPRDHKPGPRVVGRPMPGFVTLKIVDPDTFEPVDRGRPGLVLAKTKARCAGYYGE
                     PERWKEKLVGDWWNTGDIGILTPTGALKIVDREVNFASGIGYLEFEDTLVDRLPEGSDV
                     AILPRDNDLPLPVVATRDGRLDDIDWSRARTGLPALADPVVIAATDMPRTATGKIVREE
                     LRRTHLDTVATPGTGRWT"
     aSDomain        complement(10987..12138)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_L3Q65_RS42535_AMP-binding.1"
                     /evalue="1.30E-54"
                     /label="L3Q65_RS42535_AMP-binding.1"
                     /locus_tag="L3Q65_RS42535"
                     /protein_end="432"
                     /protein_start="48"
                     /score="177.2"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="LVRDSAGVLSKAGVKPGDRVVVYKANHFDCILLAAAISRLGAVAV
                     ILSGLLGKEAAQSLIRRVEPSAVVTDAERIERAEITPEAFPDLAGKIFSVNGDSPHAQT
                     YADLKAEPHLHPVPRRDDELLMLTHTSGTTGIPKLIIFPPATIQKQMARLECRHFPPLT
                     FRRNDVVAMFTPYVHARAFTWIYSVLTLSPATVLAMDDSSPDVVDRVFRRYQPTFMEAL
                     PIDYSAMAPLIRTGANNPFARIRLFAGNFDAIRWPVIRRFLNASRHPFPLWRDGYGQSE
                     TGGMGMTVLSRRSANRPRDHKPGPRVVGRPMPGFVTLKIVDPDTFEPVDRGRPGLVLAK
                     TKARCAGYYGEPERWKEKLVGDWWNTGDIGILTPTGALKIVDRE"
     misc_feature    complement(12576..12591)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.93"
                     /tool="antismash"
     gene            complement(12790..13575)
                     /locus_tag="L3Q65_RS42540"
                     /old_locus_tag="L3Q65_42535"
     CDS             complement(12790..13575)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009073316.1"
                     /locus_tag="L3Q65_RS42540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42535"
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_237598145.1"
                     /transl_table=11
                     /translation="MSSSDVPALRNGLSVLRLLAGHAGPVSAAAIARDLELPRSTTYHL
                     LNELTAAGFVTHLPAERRYGLGIAAFELGSAYLRHDPLERLAGPLLRKLVDRIGHTAHL
                     GVLHGNESLYLIKERPARPETLVTDVGVRLPAHLTASGRAMLQHLPAAHVRALFPAAAS
                     FVLRTPRGPNSLAALRRTLATERRLGWSVEDGHVTAGFASVAAPVFDHGSRPMAAISVT
                     LRHLCPDDGPCEETFPDLAEAVAATAATLTTHIGGTRPA"
     gene            13756..15282
                     /gene="hutH"
                     /locus_tag="L3Q65_RS42545"
                     /old_locus_tag="L3Q65_42540"
     CDS             13756..15282
                     /EC_number="4.3.1.3"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004397 - histidine ammonia-lyase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006548 - L-histidine catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hutH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009073318.1"
                     /locus_tag="L3Q65_RS42545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42540"
                     /product="histidine ammonia-lyase"
                     /protein_id="WP_237598146.1"
                     /transl_table=11
                     /translation="MPEPVLLSSKPMTAAQVVDIVRGHAHVGLAETVEKNLAATRQHIE
                     DLADATSPTYGVSTGFGALATRHIPVESRTALQRSLIRSHAAGAGPAVEPEVVRALMLL
                     RLRTLASGYTGVRPQTAQTLAALLNADITPVVHEYGSLGCSGDLAPLAAVALALMGEGE
                     VFHAGERKPAADALRAAGITPLVLAEKEGLALTNGTDGMLGMLLLAAADLHRLLDVADL
                     TAAMSVEALLGTDRAFAADLQALRPHPGQATSAARMFAALQGSKIVESHRGPDCNRVQD
                     AYSLRCAPQVHGAARDTLTHAELVAERELWSAVDNPVVLADGRVESNGNFHGAPVAYVL
                     DFLAVPVADVASIAERRTDRMLDQARSHGLPPFLAHDPGVDSGHMIAQYTQAAVVSELK
                     RLAVPASVDSIPSSAMQEDHVSMGWSAARKLRKAVDGLTTVLAVELLTAARALDFRAPL
                     RPSPVTGRVRDLLRTKVEGPGPDRHLAPEIAAAEELVRSGAVLAAAELEA"
     gene            15285..16946
                     /gene="hutU"
                     /locus_tag="L3Q65_RS42550"
                     /old_locus_tag="L3Q65_42545"
     CDS             15285..16946
                     /EC_number="4.2.1.49"
                     /GO_function="GO:0016153 - urocanate hydratase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006548 - L-histidine catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hutU"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009073319.1"
                     /locus_tag="L3Q65_RS42550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42545"
                     /product="urocanate hydratase"
                     /protein_id="WP_182895326.1"
                     /transl_table=11
                     /translation="MTSTARTVRAARGTSLTAKNWQTEAALRMFHNNLDPEVAERPDDL
                     VVYGGTGRAARNWASFDAITRELTALEQDETLLVQSGKPVGVFRTHEWAPRVLIANSNL
                     VGDWATWPEFRRLEQQGLTMYGQMTAGSWIYIGTQGILQGTYETFAAVAKKRFGGTLRG
                     TLTVTAGLGGMGGAQPLAVTMNDGVALCIEVDAQRAHRRVEHRYLDEVADDLDDAIRRV
                     TAAKKERRPLSVGVVGNAAEVLPELLRRDVEVDIVTDQTSAHDPLSYLPKGISVDDWQD
                     YAAKKPDEFTDRARESMADHVDAMLGFLDRGAEVFDYGNSLRGEAKLGGCERAFDFPGF
                     VPAYIRPLFCEGNGPFRWAALSGDPDDIAATDRAMLELFPENESLARWIKMAGERVAFQ
                     GLPARICWLGYGERHLAGLRFNEMVASGELKAPVVIGRDHLDSGSVASPYRETEGMADG
                     SDAIADWPLLNALVNTSSGASWVSIHHGGGVGMGRSIHAGQVSVADGTPLAAQKLERVL
                     TNDPGMGVIRHVDAGYDRAAEVADERGVRVPMREQA"
     gene            16943..18139
                     /locus_tag="L3Q65_RS42555"
                     /old_locus_tag="L3Q65_42550"
     CDS             16943..18139
                     /GO_function="GO:0016813 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds, in linear amidines
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020643750.1"
                     /locus_tag="L3Q65_RS42555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42550"
                     /product="allantoate amidohydrolase"
                     /protein_id="WP_237598147.1"
                     /transl_table=11
                     /translation="MTASGLLGEIADVGRDARRGGYSRHAFDAPEHDLRTWFVERAQQL
                     GLDVETDRNGNLWAWWGAPGADAVVTGSHLDSVPGGGAFDGPLGVVSALAAVEALQAKE
                     FRPAKPFAVVVFAEEEGGRFGVPCLGSRLLTGTIDADRARALRDPSGVTFAEAAAKSGL
                     DVDRVGADPDRLGLIGRFLELHVEQGRGLIDLGSPVAVGNTVIAHGRWRFSFAGQGNHA
                     GATLLADRVDPMLPAAETVVAVRRLARKTPDARATVGRLVPTPGGTNVIASTVDLWLDA
                     RVPGASTPALVEEITQAARAAAEAEGCELAVTRESYSDDVVFDESLRRSLGEWLGTPPE
                     LPTGAGHDAAILSGFVPSGMLYVRNPTGISHAPEEFAEADDVEAGVRALAEVLERLAR"
     gene            18136..19440
                     /locus_tag="L3Q65_RS42560"
                     /old_locus_tag="L3Q65_42555"
     CDS             18136..19440
                     /EC_number="3.5.3.13"
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009073323.1"
                     /locus_tag="L3Q65_RS42560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42555"
                     /product="formimidoylglutamate deiminase"
                     /protein_id="WP_237598148.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 1.4e-39, bitscore:
                     135.3, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTYWCERAWLPDGIAEAVRIEIAGGRIVSVTADTDTTGTVLNGL
                     TLPGFANGHSHAFHRALRGRTHHERGTFWTWRERMYSLAARLDPDAYYRLARGVYAEMV
                     LAGYTSVAEFHYLHHGPGGKPYASPNAMGDALRQAARDAGIRMTLLDTCYLAGGIGVPP
                     DEVQQRFSDGSAEKWAERVALLKEDDLFRVGGAIHSVRAVPEYELPKVDNAVPKDRPLH
                     IHLSEQRAENEQCEAAYRWTPTGLLWDYGVLGERLTAVHATHLTEQDIKWLGDSRSGAC
                     FCPTTERDLGDGIGPARSLLDAGARLGIGSDSNAVVDAFEETRALELDDRLASEERGRF
                     TAEELLSAGTEHISAGWPETGTLAPGAGADLVTVATDTVRTAGIEPSGVLFAAAAADVR
                     TVVVAGREVVRDGAHMLIERPETLLAKEIEALWQY"
     misc_feature    19402..19404
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            19428..20573
                     /gene="hutI"
                     /locus_tag="L3Q65_RS42565"
                     /old_locus_tag="L3Q65_42560"
     CDS             19428..20573
                     /EC_number="3.5.2.7"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0016812 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds, in cyclic amides
                     [Evidence IEA]"
                     /GO_function="GO:0050480 - imidazolonepropionase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019556 - L-histidine catabolic process to
                     glutamate and formamide [Evidence IEA]"
                     /codon_start=1
                     /gene="hutI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020662264.1"
                     /locus_tag="L3Q65_RS42565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_42560"
                     /product="imidazolonepropionase"
                     /protein_id="WP_237598149.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 6.6e-16, bitscore:
                     57.5, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVLITGIGELTTNDPELGKLRDAALVLDGETVVWAGPAAQAPDA
                     DERVDVEGRAVLPGWVDSHTHLVFAGDRTAEFEARMAGQAYAAGGIAVTVDATRAASDE
                     QLAANLRRHVEEAAAQGTTCLETKTGYGLNVVDETRSARIAGEVADEVTFLGAHLVPPG
                     ADAESYVDLVCGEMLDAVAPHVRWADVFCETGAFDEAQSARVLKAAAERGLGLRVHGNQ
                     LGEGPGVRLAVELDAASVDHCTYLSDADVEALASSNTVATALPACDLSTRQSLAPARRL
                     LDAGATVALASNANPGSSYTTSMAFCVTTAVLQMRMTVDEAVWSATAGGARALRRDDVG
                     YLRPGARADVHVLDAPSTTHLAYRPGVPLTHAVWRKGAKLR"
ORIGIN
        1 gacctcggcg tcctctacga gctcgccgcc gacgaaggcg acaccggcag catgaccgag
       61 gccgagagcg acctcgccga cctcgccaag gacatcgacg cgctcgaggt ccgcaccctg
      121 ctgtccggcg aatacgacgc ccgcaacgcg gtcgtcaaca tccgctccga agcgggcggc
      181 gtcgacgcgg ccgacttcgc cgaaatgctg ctccggatgt acctccgctg ggcggaacgg
      241 cacggctacc cgacggacgt cttcgacatc tcctacgccg aagaggcggg catcaagtcc
      301 gccacgttca aggtgaccgc cccttacgtc tacggcaccc tctcggtcga acagggcacc
      361 caccgcctcg tgcggatctc gccgttcgac aaccagagcc gccgccagac gtccttcgcg
      421 cacgtcgagg tcctgcccga ggtcgaggaa gtcgaccacg tcgacatccc ggaaaaggac
      481 atccgcgtcg acgtgtaccg ctcgtccggc cccggcgggc agagcgtcaa cacgaccgac
      541 tccgcggtcc gcctcaccca catcccgacc ggcatcgtcg tttcgtgtca gaacgagaaa
      601 tcgcagctgc agaacaaggc ggccgcgatg aaggtcctcc aggcgcgcct gctgcagcgc
      661 aaaaaggagg aggaacgggc cgaaatggac gcgctcaagg acggcggctc cagctggggc
      721 aaccagatgc gctcctacgt gctgcacccg taccagatgg tcaaggacct gcgcaccgaa
      781 ttcgaggtcg gcaaccccac cgcggtcctc gacggagaca tcgacggctt cctcgaagcc
      841 gggatccgct ggcgcaagca ggcgaacgcg gcctgatccg cactgccgcg gcgacccgcg
      901 ccaggacgag gcgcgggtca cccaaggcac cggcaacccg ggcttaacgg ggcccatggg
      961 taggatgccg aaccgtgatc cggctcgaag aggtttccaa ggtctacaag acctcgaccc
     1021 gtcccgccct cgaacgggtg tcggtcgaga tcgacaaggg tgagttcgtc ttcctcatcg
     1081 gcccgtccgg ttccgggaag tcgacgttcc tgcggctgct gctgcgcgaa gaggtgcctt
     1141 ccaagggccg ggtcatggtg tcgaacttcg acgtcgccaa gctcgcccgg cgcagggtcc
     1201 cccgcctgcg ccagaccatc ggctgcgtgt tccaggactt ccggctgctg gccaacaaaa
     1261 ccgtcgcgga aaacgtggcg ttcgccctcg aggtcatcgg gaaaccgcgg cccacgatcc
     1321 gcaaggtcgt gcccgaggtg ctcgaactcg tcggcctcga cggcaaagcc gaccggctgc
     1381 ccaacgagct ctccggcggc gagcagcagc gcgtcgcgat cgcccgcgcg ttcgtgaacc
     1441 gcccgctcgt gctgctggcc gacgagccca ccgggaacct cgacccggac accagccagg
     1501 acatcatgct gctgctggag cggatcaacc gcaccggcac caccgtgctg atggccacgc
     1561 acgaccattc catcgtggac tcgatgcggc ggcgggtcgt cgagctgcag ctcggtcgcg
     1621 tgatccgcga cgacgccagg ggcgtctacg gcatcggccg ctgacgccca ccgcccccgc
     1681 cccttcccgc cccgaaccaa ggaatcacga gagcgatgcg tgccagtttc gtcttcagcg
     1741 aggtcgtcac cggtttgcgc cggaacgtca cgatgaccat cgcgatgatc ctcaccaccg
     1801 cggtctcgct cgccatgctc ggcggcggtc tgctcgccgt gcgcacgatc gacaagatga
     1861 aggcgaactt cctcgccgaa gtcgaagttt cggtcgcgct ggtcgacgac gtgagcgcga
     1921 acgacaagaa ctgcacgcag gcgctctgca acgggctccg ccagtcgctg cagaacaacc
     1981 ccggcgtcga atcggtcgtg tacgagaacc gcgaccaggc ctacgaccgg ttcaagaaga
     2041 tcttcgcgag ccagcccgaa ctgctcgagc tgaccggccc cgaggcgctg cccgcgtcgc
     2101 tgcaggtgaa gctgaaggac ccggaccggt ccgacgcgat catcaagcag tacaccggcc
     2161 agcccggcgt caagaaggtc gacgaccaga agaagttcct cgaccgcgtg ttcaacgtct
     2221 tcaacggcgt ccggaacatc gcgttcgtga tggcactcat catggccgtc gctgccctgc
     2281 tgctgatcgc gaacaccatt caggtttcgg cgttcacgag gcggacggaa gtcggcatca
     2341 tgcgcctggt gggcgcgacg cggtggtata cccagttgcc gttcctcttg gaggcggtgg
     2401 tcgccggcac ggtcggcgcc gtgctcgggg tggtgttcct gcttctgacg aagctgtcct
     2461 tcctcgacac ggtcttcacc ggcgaagtgt tcccgcagat caccacgctt gaggtgctgt
     2521 tcccggtcgc gccgatcctg ctggcggtgt cgatcgtgat ctcggcgatc accgggtacg
     2581 tcacgctgcg cctgtacgtg cggcactagc ggagaagaaa tcggctgctc gccgtcggac
     2641 acatcacgta aagtggtcgg tatgcccaag gaacgtggac agaaggtcat cgcgtcgaac
     2701 cgcaaggctc ggcacgatta ctccatcctg gacacctatg aggccgggat ggtgctgcag
     2761 ggcaccgagg tgaagagcct gcgggcgggc aaagcctccc ttgtggacgc gttcgcgacg
     2821 gtggacgacg gcgaggtgtg gctgcgcaac gtccacatcc ccgagtacac ccagggcacc
     2881 tggaccaacc acatgccgcg gcgcacgcgg aagctgctgc tgcaccggcg cgagatcgaa
     2941 cggctcatcg gcaagaccaa ggaaagcggt ctgtcgctcg tgccgctgtc gatgtacttc
     3001 aaggacggca aggtcaaggt cgagatcgcg ctggcccgag gcaagaaggc ctacgacaag
     3061 cggcagtcgc tcgccaaacg cgacgcgcag aaggacatca gccgcgcgat ggggcgggcg
     3121 ttgaagggcc ggttcacgga gtgacggctg gtccggccac cgacgccgac gtcccgggct
     3181 ggatcgccgg gctcggcctc gacgggatcg tcgacctgca cgtccacttc ctgccgaagc
     3241 ccgtgctgga caaggtgtgg gcgtatttcg accgcgccga gcagcattac ggcacaccgt
     3301 ggccgatcca ctaccgcacg cccgagccgg agcggatcga cacgctgcgc gcgctgggcg
     3361 tgaaagcctt cgcgccgctg gtgtacccgc acaagccggg catggcggag tggctcacct
     3421 cgtgggtgct ggacttcgcc gaccaggtgc cggaagcggt gcccaccggc acgttctacc
     3481 cggagccgag cgcggcgtcc tcagtggaca gtgcgttgcg cgcgggagcc cggtgtttca
     3541 aggcgcacgt gcaggtcggg gcttacgacc cgcgggacga gctgctcgac ccggtgtggg
     3601 gctcgctgtc cgaagcgggc gtgccggtgg tgatccactg tggacacgga ccgttgcgcg
     3661 gcgacttcac cgggcttgag gtgttcgagg aagtcctgca acggcatccg cggctcaccg
     3721 ccgtcctcgc gcacgcggcg atgccgcagt tcaccactgc gttcgagctg atggcccgct
     3781 acccgcgagt gcatctcgac accaccatgg tcggcgtgcc gttcgcggag gcgatgtcgc
     3841 cgctgccgcc ggactggacg gtccggctgg cggaggtggc cgatcgcgtc gtcctcggca
     3901 ccgacttccc gaacatcccg tactcctacg ccacacagct gcgggcgatc gccggctggg
     3961 cagccgacaa tcgccttggc gagccgttcc tgcgggcggt gctgcacgac acccccgcga
     4021 agctcctcag cgtttgaccg ccacgagagc ccggctccgc ggcatcgaca cctgacgtcc
     4081 ggccagcgcg tacccggccg cgaccagcgc cacccacggc agcggaccgg tcagcaggtt
     4141 gtcgttgagc ggcgcgaacc cgtgcgcggc cagccccagg agaccgccgg aggcgagcag
     4201 gcccgccagc accagctgcg gcgtccgagc ggtcacgacc aggccgtccg gctgcatttc
     4261 gaagcgctgg aacaggcgca gcagccccag cagcaccgcg ccgcacacgg cgaaccaggc
     4321 gggtgccatc aggaaccaca tcgacgaacc cggggtcggc gtcgagtagc cgaggccgaa
     4381 gacggtcacg ccggacacca cgaccagtgc gggcatgtgc cagagataga ccgacatgaa
     4441 ccgcgggctg agccagctga gcgccgcggt gacgcgtggg agcgagacaa gcttctcgcg
     4501 gaaggccagc aggaacccga tctggccgag cgccaggaac agcagcagga cggtgggcgg
     4561 gctcatgttg gacaccggcg cgcccggcat gccgatcatg ctcgccgggt acggaccgaa
     4621 cgcgaccagc agcgccgtca ccccgaaacc ggcggcggac acggcgagcg ccgcgcggcg
     4681 gctgagcgcg ccgagacggc cttcgacgta gtggaaacca agctggtgca cggcgaccca
     4741 gacgatgacg gcgttggcgt atccgatcat cccgaggtcg gagaaccgcg ccacgtcaac
     4801 gagaacgccc agtccggcca gtaccgccgg aaccgcgaga ccccagcggc ggtgcgcggc
     4861 gaccatcaac ggcgtgagca gcacggtgag caggtagacc gagaggaacc agagcagttg
     4921 cgccgcgatc gcgctggcca cctggaccgg ttgcggcgga actcccatgc cctgcaacag
     4981 atccggtacg acgagccaca ccgccatcag cggcagaacc ggaacgagca ggcgacggac
     5041 gcgtccggcg aaccaggcgc gcgtggattc cgcgcggcgc aacgagatca ggttcgccgc
     5101 gccgccggcg aagaagacga ggggcatgac ttgcgaggcc caggtgatga tccaccagcc
     5161 gggggtcgcg agggcgttgc cggtggcgag agtggtgccg gagaaggaaa gcaccggcat
     5221 cgtccagtgc tgcgcgacca ccgcgaggat cgctccggcg cgtaccacgt cgagaaattt
     5281 gtcccgggtt gcccttgcgc cgcgggtctg cagctggctc gtcgtcatgc tgaagagcct
     5341 gtcgcgttcc gggtgcggaa acagcggtgc tgaccaccga aaacggggtc gggtcagcag
     5401 gaggcgaaag gtggggtttg ccctaccgcg ggttctcgtg aacggcaatg ccggttccaa
     5461 ccggcataaa cactcacgag agggtgtccg gctccggctc ggactcgtgc gcctgcaccc
     5521 ggtaggccca gccgttctcg gtcaggccga gttcgtaccg cgtctcgatt ttcgggccgc
     5581 cgtgcaggtg gatgtggcgc actacggtgc ccggaaccgg ttcctcgtcg gcgagttcct
     5641 gcacccggcc gtcgagcggg ccgccgaaga agcggacgct gcggtcggac atcggactct
     5701 cctcgctcgg ctcggacatc agtccatggt aggcgaggaa ccgccgtcga tgctgccgtc
     5761 agttcgagtg aggggtatca acggccgagg taggtcagca ccgcgcgaac ccggcgatgt
     5821 tcttcggaac tggcctcgag accgagcttc gagaagatgt tgccgatgtg cttttcgacc
     5881 gctccgtgcg acaccaccag cgagttcgcg atggcgttgt tggacagtcc ctgcgccatc
     5941 aggccgagca cctcggactc gcgcgcggtg agcgaatcga gcggattgcg gcggccgcgg
     6001 gccatcagct gggcgatgac gtcggggtcg atggcggtgc cgccgtccgc gacgcgccgg
     6061 accgcgtcca ggaactcgtc cacgtcggcg acgcgctctt tcagcaggta gccgacgcct
     6121 ccggcgcctc cggacagcaa ctcgaccgcg tagctttcct cgacgtactg cgagagcacg
     6181 agcaccggca ggccggcgat ctccttgcgg gccgccagcg ccgcgcgcag gccctcgtcg
     6241 gtgaacgtcg gcggcatccg gacgtcgaca atcgccaggt caggacggtg ttcggtgatc
     6301 gcgccgagca gatcgtcccc gttgtcgacc gcggcgacgg tctcaatgcc ctcgtcggcg
     6361 agcaatcggg tgaccccggc ccgaagcaac acggcgtctt cggcgatcac tacccgcatc
     6421 aaggccccca ggtccgtgag tgaaaagctc ccgcaggcta ttcactcacg gacgggtcac
     6481 cattgacacg gcaggtccgc tctgatgacc gtcggcccgc cgaccgggct cacgacggtg
     6541 atcacgccgt cgatggtcgc cgctcggtcg gccagcccgg cgagcccact gccagggcgc
     6601 acctcggcgc cgccgtgccc gttgtcggtg atttcggtga tgacgtgcgt ttccgagcgc
     6661 cagaccttca ccatcgcctc ggtcgcgccg gagtgcttgg cgatgttggt gagggtctcg
     6721 ccgacgatga agtacgcggt ggtctcgacc gcggccggcg gccggggctc gacgttgacg
     6781 tgcacgtcca ccgggatcgg tgacttcgcg gcctgcgcgg acagggccgc gtcgagaccg
     6841 cggtcgccga gcacggcggg gtagatgccg cgggcgaggt cgcgcagctc ggagacggcg
     6901 agcttggcgt ccgaatgggc ctcgtcgatc aggtcgcgca ccgcgttcgg gtcgttgtcg
     6961 aacttcgact tcgcccggcc gaggctcatc gcgaccgcca cgagccgctg ctgagcgccg
     7021 tcgtgcaggt cgcgctcgat ccggcggcgc tcggcctccg cggcgtccac gccacgagcc
     7081 cgcgacgcct ggaggtgttc ggccttcttt tcgagcttct tcgtgcggtt cgggcctagc
     7141 agcgacagcg ccaggttgcc gtgcaaccag ccgagccacg gcgtcaccca gatcgccatc
     7201 ggcagcagca cgatcgacgc gagcgcgatc ggcagctcga cgatcgccag cgggaacgcg
     7261 accatcaggt aagccaggtc acgccaggtc gtcgggtcgg acagccgggt cagccagcgg
     7321 cgggtcatcg gctgcccgtc cagcggcagc cgctcgaccg ggccgagcgg ggtgccgagc
     7381 atccggcggg cccagcgccg ctccaggtcg cccgaccagc ggatgaagcc ggtgacggcc
     7441 agcaggatcg ggaagccgat ccagatgatg agcgtcgccg tgccggcggt cgcgccgacc
     7501 acgatgagga tgaactgcag caggcgcagc acgaacgacg ggatcatgta cgcgatcgtg
     7561 cgtgccggat gcggacgagg gtgctccgga ggcgggtctt gcgcagtcat ccggccaccg
     7621 tgatcccgtc gatctcgttc cacgagcgct ccatgcgccg ccgctgggcg accgtgggcc
     7681 gcaggaaccc ggccgcgaac gcggcgtgca gggccgccag ccccttggtg agggccacgg
     7741 cgatcgcggc gaacagcacc cccagcgccg cccaaggcag cgcggtcacc gtcgagtcga
     7801 cgacgaacca ctgcacatcg tagctcggga aggcgtagac gccgtccgga aggaagcggt
     7861 agtagacggg caggccgacc aggcccaagc tgaccgccca caccgtcacg accagcacga
     7921 actccaccag gccgagcggg aagagcaaga acaggtagga caggtcacgc caggtcgccg
     7981 ggtccttcag ccgggtcagc cagcgctgct tctgccctga cggcggcaac ggcagatacg
     8041 gatcgtcgat gtacacgtcg agcagcgcga acacccgccc ccgctcgacc cgccccgcgg
     8101 tccgcgcgaa caggacgagc agcgcgagca gcggaacccc cagccacacg atgagcgtcc
     8161 ccagcccggc cgacccgagc gtcacgatga gcgtgaacga gaggatcccg acaggcaggt
     8221 tgagcaggag atacgccaac gccccgccca acggcggagt gcggcgccca aaagtgcgac
     8281 cggcgggcac ggtgaccatg gcggggctcc ctcactgcgg aaactgacct gctcagcatg
     8341 gccggagcgg caccgggcaa ccagggggcg agcgggcatc ttcggggtgg ggccagccct
     8401 accccatgcc ggaattatcg ggttgccgcg cgggttatga tggtgaggtt acaagcacct
     8461 acaagggggt gaacggtttc gactctggac gttgaatcaa gggaagcgtg ccggtgcagg
     8521 cgagagacca ccgcaagcgt catcgcaacc taataagcgc caaggccaat agccagcgcg
     8581 acttcgctct cgctgcctga tcgcagtaga gcaagtctgt cggcccgggg tcgcctccga
     8641 cccggtcgcc ggcatcagct aggaggctta ccgccggtcc cggccacggg gcccggtagg
     8701 gaagcaaaca gtggctgggc ccgtcacttc agcttgttcg cgtgactgaa ggggccaagc
     8761 agagacacag cggactgcgc acggagaagc cttgaggagg cgctagagga cccgggttca
     8821 attcccggca cctccactcg attcgcggga gagccctgcc cacgctgtac gcgtgggcta
     8881 gggctcttct tcgtcattcc ccttgggggt cggaccccca aacccccgcc agggggcgca
     8941 gccccctgga cccccatcgc ggtgggtgcg tttggttggt ggggttctgc aagagggggc
     9001 ggcggggttg ccgtttttct gtggcttcga tcccgccgct gcttggtgcg ctcttcgttg
     9061 acaccggttg ctcccgaacc ggattggggg cgcacggttt cgcagcgggc ctggcgtcct
     9121 gcgaggacaa caccactgcg gtgatcgcgg cggccgcgac tgctacgagt gccgcttgtc
     9181 ctgagaatgc gcaacgcagc cggttcgtgc tggacgcgcg aaccggctgc gttgggggcg
     9241 tgctgctacg gctttgttgc ggtgatagtc aggctggtcg ggttctttgc gcagcgagcg
     9301 gcacggtcct ggtcagctgg ggcgacagtc tcggagggct tcaccaaatc ccacgagacg
     9361 ttcgtgaacc cggcggtttc caggacttcg acgatcgtct ccgtgggcca gtggtgtact
     9421 tcgatttccg tgggcggcgt cgtcaggacg gctaccttga acttgtcgcc ttccttgggg
     9481 ttcgccgggc ggtaggtgcg gaagcccgct gcggtttcgg attcttcgct ggagttggcg
     9541 ttcgcgctca ggattgccag cttgccgccc ggtttgaggt tggcgtgcat ggtgttcgcc
     9601 atggtttgca tggtcttccg ggtgtccgcg tagtgcagga catggatggc tgtcactacg
     9661 tcgaactcgc cttggggcgg cattgccgcc aggtcttgga cctcgtaggt gatgccttgc
     9721 gggtttcgcg cttccgcctg ctgggccagc gcgatcatgc cgggcgagag gtcggtgccg
     9781 actacttgcg cggcgcccaa ctgcttgatg cggcgggtga agctgccttc gccgcagcct
     9841 acgtccagta ctcgcaggcc gcgcagatcg cctagcaaat ccttgaacga gggccattcc
     9901 aagttttccc ggacgaagct gattatcgct tccacgtcgg cgaaagcagt ggctacctgg
     9961 tcgtactggt cgacggattc cgtcatcgaa atctccggtt tcaggcgggg cggatggtgg
    10021 cgtagccctg gcctggttct ggtttcaggg ctgcggcgtc cgagaagatt acgttcgcca
    10081 gggggagggg ttgatggtag aagttcaggg aggcgtctac ctcgaagatt ctgcaggaag
    10141 atacgaagaa aggcagttcg gcgatgaggt agtttttcgc ttcggcgatt tgcgcgggcg
    10201 tggcatcgcc ggtcagtcct ttggcagcca gcacttcttt ggtcatttct gtgctggctg
    10261 aagccagagt ggggtccgcc gcggtcaggt gggtgcagtg ctccagaacc tcggtgtagg
    10321 tgaggttttc cgagagttcg gacatgcggt gcaggccgtc ggctggtctt gggccgccca
    10381 ggtccgtcca tgctcggagg actcggttgc gcaggacgtt ggtttccgac cgggccttct
    10441 tcgctgcctt ggcctcgtcg tagcccaggg cggtgaaggt gtgtttcagt gcgctgtcgg
    10501 ggatgacgac gtcgatttgc ttgaattccg tttgcagcca gtccaaagtg gaacgcaggc
    10561 ggtcgacgtt gaagtagctg ttgcccgggc tgacaccgaa aaccgcgtgg cggcgggatt
    10621 cccagacctc tcggcaggac gtggtcaagg gttccacgct gaagccgttg ctgatcatgt
    10681 ccagcgtccc gtgccggggg tggcgacggt gtccaggtgg gtgcggcgca gttcttcccg
    10741 cacgattttg ccggtcgcgg ttctcggcat gtccgtcgcg gcgatgacga cggggtcggc
    10801 cagtgcgggg aggccggtgc gggcccggga ccagtcgatg tcgtccaggc ggccgtcccg
    10861 ggtggcgacg acggggaggg gcaggtcgtt gtcacggggg aggatggcga cgtccgatcc
    10921 ttccggcagg cggtctacca gggtgtcttc gaattccagg tagccgatgc cggacgcgaa
    10981 gttgacctcg cggtcgacga tcttcaatgc cccggtcggg gtgaggatgc cgatgtcgcc
    11041 ggtgttccac cagtcgccca ccagtttttc cttccagcgt tcgggttcgc cgtagtagcc
    11101 ggcgcagcgg gcctttgttt tggccagaac caggccgggg cggccgcggt cgacgggttc
    11161 gaaggtgtcc ggatcgacga tcttgagggt gacgaaaccg ggcatcgggc ggcctacgac
    11221 gcgcgggccg ggtttgtggt cgcgcgggcg gttcgcggag cggcgcgaga gcacggtcat
    11281 gcccatgccg ccggtttccg actggccgta gccgtcgcgc cagagcggga acgggtgccg
    11341 ggacgcgttc aggaagcggc ggatgaccgg ccagcggatc gcgtcgaagt ttccggcgaa
    11401 caagcggata cgagcgaacg ggttgttcgc gccggtgcgg atcagcgggg ccatggccga
    11461 atagtcgatc ggcaaggctt ccatgaacgt cggctggtag cggcggaaaa cgcggtcgac
    11521 tacgtccggg gagctgtcgt ccatggccag cacggtggcc ggggacagcg tcagcaccga
    11581 atagatccag gtgaaggccc gggcatgcac gtagggcgtg aacatggcca cgacgtcgtt
    11641 gcggcggaac gtcaggggcg ggaaatggcg gcattccagc ctggccattt gtttttggat
    11701 cgtggctggc gggaagatga tcaatttggg gatgccggtg gtgccggagg tgtgggtgag
    11761 catgaggagt tcgtcgtccc ggcgggggac ggggtgcagg tgcggttccg ctttgaggtc
    11821 cgcgtaggtc tgcgcgtgcg gggagtcgcc gttgacgctg aagatctttc cggcgagatc
    11881 cgggaacgcc tcgggggtga tttccgcgcg ttcgatgcgt tcggcgtcgg tgacgaccgc
    11941 tgacggttcc acccggcgga tcaggctttg tgcggcttcc tttcccagca aaccggacag
    12001 tatcacggcg accgcgccga gccgggagat cgcggcggcc agcagaatgc agtcgaaatg
    12061 attggctttg tagacgacca cccggtcgcc gggtttcacg cccgctttac tcagcacgcc
    12121 cgcggaatcc cggaccaagg ccgcgatcgc gggcaggtcg aggctcgagc ggtcttcccg
    12181 gtcgatgtcc agcggccggg acaggtggaa tgtcatgggc ttgccggaac tgcttcggtg
    12241 atcgaacagt tcgcccaggc tgaaggccca gttcggtttc atggatgaag tgctcctatg
    12301 cggtgctgtc cggcagcaca aggtcggttg ccgccctcgc ccgaatgcgg gcaagggtga
    12361 gcgcagcgag tcgaattgcg cgcgaatcgc tgtgcgggaa tgttcgaaag gcagagcaat
    12421 gccgatccgg gcaccgcccc cgcggcaccc ggatcagtga aggtggccta ccggttgccg
    12481 gtaagcaaac aagcaggaac gtactgaagc gaatccactc aagccccctg atgttttgag
    12541 tttcgcttta aacccattag agctatacct gagcggatag tgactgtcaa tcgtccgttg
    12601 gcggtggtca atgcgggtat tacggcaagt gggggacgcc gtgcggtggc gccgcagtgc
    12661 ggtcgtgtcg gttttgtcgt agcttgaatg aagcgcttgc gcagttgaac acttcggtta
    12721 aggtatgctc gttcgcgggg acgttctggg ggttagtgtt ttatttctgg gggaattgac
    12781 gggagggtgt cacgctgggc gggtgccgcc gatgtgcgtg gtgagtgtcg cggctgtcgc
    12841 ggcgacggct tcggccaagt cggggaaggt ttcttcgcag gggccgtcgt ccgggcaaag
    12901 gtggcgcagt gtcacgctga tcgcggccat cggcctggaa ccgtggtcga atactggggc
    12961 ggcgacagag gcgaagcccg ctgtcacgtg accgtcttcc actgaccagc cgaggcggcg
    13021 ttcggtcgcc aaggtgcggc gtagcgcggc cagcgaattg gggccgcgcg gagtgcgcaa
    13081 gacgaatgac gcggcggccg ggaacagggc gcggacgtgt gcggctggca gatgctggag
    13141 catcgcgcgg ccggacgcgg tcagatgcgc gggcagtcgc acaccgacat cggtgaccag
    13201 ggtttccggg cgggccgggc gttccttgat caggtacagc gattcgttgc cgtgcaggac
    13261 gccgaggtgc gcggtgtggc cgatgcggtc gaccagtttg cgcagcagcg gcccggccag
    13321 ccgctccagt gggtcgtggc gcaggtaggc cgagccgagt tcgaaggcgg cgatgccgag
    13381 gccgtagcgg cgttcggcgg gcagatgggt gacgaaaccg gccgcggtca gttcgttgag
    13441 caggtgatat gtcgtcgacc ggggcagttc gaggtcgcgc gcgatggccg cggccgagac
    13501 cgggcccgcg tggccggcga gcaggcgcag cacggagagg ccgttgcgca gggcgggaac
    13561 gtcggaactg ctcactgggg gctcctctgc ctcctccgga aacggcgcga ggggacccct
    13621 cgcactgccc gaacggagta tgaggggtcc cttcgcaccg gtggtcgagg ctctcgccac
    13681 gtgttgtctt ggataccaga cactaccgcg aactccgccc tgtcgccgcg gcccgccggg
    13741 aggtgcaatg gcggcatgcc ggaaccagtc ctcctgagct cgaagccgat gaccgcggcg
    13801 caggtcgtcg acatcgtccg cgggcacgcg cacgtcgggc tcgccgagac ggtcgagaag
    13861 aacctcgccg ccacccgcca gcacatcgaa gacctcgccg acgccacgtc gccgacctac
    13921 ggggtctcga ccggattcgg cgcgctcgcc acgcgccaca tcccggtcga gagccgcacc
    13981 gcgctgcagc gcagcctgat ccggtcgcac gccgcgggcg ccgggccggc ggtggagccg
    14041 gaggtggtgc gcgcattgat gctgctgcgc ctgcgcacgc tggccagcgg ctacaccggc
    14101 gtccgcccgc agacggcgca aacgcttgcg gcgctgctca acgcggacat cacgccggtc
    14161 gtgcacgagt acggctcgct cggctgctcc ggcgacctcg caccgctggc cgcggtagcg
    14221 ctcgcgttga tgggcgaggg cgaggtgttc cacgcgggcg agcggaagcc cgccgcggac
    14281 gctctgcggg cggccgggat cacgccgctc gtgctggccg agaaggaggg cctcgcgctc
    14341 accaacggca ccgacggcat gctcggcatg ctgttgctcg ccgccgccga cctgcaccgg
    14401 ctgctggacg tcgcggacct caccgcggcg atgagcgtcg aggcgctgct gggcaccgac
    14461 cgcgcgttcg ccgccgattt gcaggcgctg cgcccgcatc ccggccaggc gaccagcgcg
    14521 gcgcggatgt tcgcggcgtt gcaggggtcg aagatcgtgg aaagccaccg cggtccggac
    14581 tgcaaccgcg tgcaggacgc gtactcgctg cggtgcgcgc cgcaggtgca cggcgccgcg
    14641 cgggacacgc tgacgcacgc ggaactggtt gccgagcggg aactctggtc cgcggtggac
    14701 aacccggtgg tgctggccga cggccgggtg gagtcgaacg gcaacttcca cggcgcgccg
    14761 gtcgcgtacg tgctcgactt cctcgcggtg ccggtggcgg acgtggcgag catcgccgaa
    14821 cgccgcaccg accggatgct cgaccaggcg cgctcgcacg gcctgccgcc gttcctcgcg
    14881 cacgaccctg gcgtcgattc cgggcacatg atcgcgcagt acacgcaggc cgccgtggtc
    14941 agcgagctga agcggctcgc ggtgcccgcc tcggtcgact cgatcccgag cagcgcgatg
    15001 caggaggacc acgtgtccat gggctggtcc gccgcgcgca agctgcgcaa ggcggtcgac
    15061 ggcctgacca ccgtgctcgc cgtcgaactg ctcaccgcgg cccgcgcgct cgacttccgc
    15121 gcgccgctgc ggccctcgcc ggtcaccgga cgcgtccggg acctgctgcg caccaaggtc
    15181 gagggccccg gccccgaccg tcacctggcg cccgagatcg cggccgccga agaactcgtg
    15241 cggtcgggcg ctgtcctggc cgcggccgaa ctggaggcct gagcatgact agcaccgccc
    15301 gtaccgtccg cgccgcccgc ggcacgtcgc tgaccgcgaa gaactggcag accgaggccg
    15361 ccctgcggat gttccacaac aacctcgacc ccgaggtcgc cgaacggccc gacgacctgg
    15421 tcgtctacgg cggcaccggc cgcgccgcgc gcaactgggc gagcttcgac gcgatcaccc
    15481 gcgagctgac cgcgctggaa caggacgaga cgctgctggt ccagtccggc aagccggtcg
    15541 gcgtgttccg cacgcacgaa tgggcgccgc gggtgctgat cgcgaactcg aacctggtag
    15601 gcgactgggc gacgtggccg gagttccgcc ggctggagca gcagggcctc accatgtacg
    15661 ggcagatgac cgccggttcg tggatttaca ttggcacgca aggcattctg cagggcacgt
    15721 acgagacgtt cgccgcggtc gcgaagaagc ggttcggcgg aacgctgcgc ggcacgctca
    15781 ccgtcaccgc cgggctcggc ggcatgggcg gcgcgcagcc gctcgcggtc acgatgaacg
    15841 acggcgtggc gttgtgcatc gaggtcgacg cccagcgcgc gcaccggcgc gtcgagcacc
    15901 gctacctcga cgaggtggcc gacgacctgg acgacgcgat ccggcgggtc accgcggcga
    15961 agaaggagcg gcgtccgctg tcggtaggcg tggtcggcaa cgccgccgag gtgctgccgg
    16021 agctgttgcg ccgcgacgtc gaggtggaca tcgtcaccga ccagacgtcg gcgcacgatc
    16081 cgctgtccta cctgcccaag ggcatcagcg tggacgactg gcaggactac gcggcgaaga
    16141 aaccggacga gttcaccgac cgggcgcgcg agtcgatggc tgaccacgtc gacgcgatgc
    16201 tcgggttcct cgaccgcggc gccgaggtct tcgactacgg caactccctg cgcggcgagg
    16261 cgaaactcgg cggttgcgag cgcgcgttcg acttccccgg cttcgtgccc gcctacatcc
    16321 ggccgttgtt ctgcgagggc aacggtccgt tccgctgggc cgcgctgtcc ggcgaccccg
    16381 acgacatcgc cgcgaccgac cgcgcgatgc tcgagctgtt cccggagaac gaatcgctgg
    16441 cccgctggat caagatggcc ggcgagcgcg tcgccttcca gggcctgccc gcgcggatct
    16501 gctggctcgg ctacggcgaa cggcacctgg ccggccttcg cttcaacgag atggtcgcca
    16561 gcggcgagct gaaggccccg gtcgtgatcg gccgcgacca cctcgactcg ggcagcgtcg
    16621 cctcgccgta ccgcgagacc gagggcatgg ccgacggctc ggacgcgatc gccgactggc
    16681 cgctgctcaa cgcactggtc aacacctcgt ccggggcgag ctgggtgtcc atccaccacg
    16741 gcggcggggt cggcatgggc cggtccatcc acgccgggca ggtgagcgtc gcggacggca
    16801 cgccgctggc ggcgcagaag ctggagcggg tgctcacgaa cgacccgggc atgggcgtca
    16861 tccggcacgt cgacgccgga tacgaccgcg cggccgaggt cgccgacgag cgcggtgtgc
    16921 gggtgccgat gagggagcag gcgtgaccgc atccgggctg ctcggcgaga tcgccgacgt
    16981 cgggcgcgat gcccggcgcg gcggttactc acggcacgcg ttcgatgcgc cggagcacga
    17041 cctgcgcacg tggttcgtcg aacgggcgca gcaactgggc cttgacgtcg agaccgatcg
    17101 caacggcaac ctgtgggcgt ggtggggtgc tcccggcgcg gacgcggtcg tcaccggcag
    17161 ccacctggac tcggtgccgg gcggcggcgc gttcgacggg ccgcttggcg tcgtaagcgc
    17221 gctggcggcg gtggaagcct tgcaggccaa ggaattccgt ccggccaagc cgttcgcggt
    17281 ggtggtcttc gccgaggagg agggcgggcg tttcggcgtg ccgtgtctcg gttcgcggct
    17341 gctcaccggg acgattgacg cggaccgggc gcgggcgctg cgggatccgt ccggcgtcac
    17401 gttcgccgag gccgcggcga agtccgggct ggacgtggac cgcgtcggcg cggatccgga
    17461 ccggctcggg ctgatcgggc gattcctgga actgcacgtc gaacagggca gggggctgat
    17521 cgacctcggg tcgccggtgg cggtcggcaa cacggtgatc gcgcacgggc ggtggcgatt
    17581 ctcctttgcc gggcagggaa accacgcggg tgcgacgttg ctcgcggacc gggtcgatcc
    17641 gatgctgccc gccgccgaga ccgtggtcgc ggtgcggcgg ctggcgcgga agacgccgga
    17701 cgcgcgggcg accgtgggtc ggctggtgcc cacgccgggc gggacgaacg tgatcgcgtc
    17761 cactgtggac ctgtggctgg acgcgcgcgt gccgggtgct tcgactcctg cgctggtcga
    17821 ggagatcact caagcagcgc gggccgcggc cgaggcggaa gggtgcgagc tggcggtcac
    17881 gcgcgagtcg tactccgacg acgtggtgtt cgacgagtcg ctgcggcggt cgctggggga
    17941 gtggctgggc actccgcccg agttgcccac gggtgccgga catgacgcgg cgatcctgtc
    18001 gggattcgtg ccgtccggga tgctctacgt ccgcaatccg accgggatca gccacgcgcc
    18061 ggaggaattc gctgaggcgg acgacgtcga ggccggcgtt cgggcgctgg ccgaggtgct
    18121 ggagcggctc gcgagatgac cacgtactgg tgcgaacggg cctggctgcc cgacgggatc
    18181 gcggaagcgg tccggatcga gatcgcgggc ggccggatcg tttcggtgac cgctgacacg
    18241 gacaccaccg ggactgtcct taacggactg acacttcccg gcttcgccaa cgggcattcg
    18301 catgcgttcc accgcgcgct gcggggccgg acgcaccacg agcggggcac gttctggacg
    18361 tggcgggagc ggatgtactc gctcgccgcc cggctcgatc cggatgcgta ctaccggctc
    18421 gctcggggcg tctacgcgga gatggtgctg gcggggtaca cgagcgtcgc cgagttccac
    18481 tatctgcacc acggcccggg cggcaagccg tacgcgtcgc ctaacgcgat gggcgacgcg
    18541 ttgcgacagg ccgcgcggga cgccggaatc cggatgaccc tgctcgacac ctgctacctc
    18601 gcgggcggga tcggcgtgcc gccggacgag gtgcagcagc ggttttcgga cggttccgcc
    18661 gagaaatggg cggaacgcgt cgcgttgttg aaggaagacg acctgttccg tgtcggcggg
    18721 gcgatccact cggtgcgtgc ggtgccggag tacgagctgc cgaaggtgga caacgcggtg
    18781 ccgaaggacc ggccactgca catccacctg tccgagcagc gcgcggagaa cgagcaatgc
    18841 gaggccgcgt accgctggac gccgaccggg ttgctctggg attacggcgt gctcggcgag
    18901 cggctcaccg cggtgcatgc gacgcacttg accgagcagg acatcaagtg gctgggcgat
    18961 tcccggagcg gcgcgtgctt ctgcccgacc accgaacggg acctcgggga cggcatcggc
    19021 ccggcccgga gcctgctcga cgcgggcgcg cggctcggca tcgggagcga cagcaacgcg
    19081 gtggtcgacg cgttcgagga gacccgggcg ctggaactgg acgatcggct cgccagcgag
    19141 gaacgcggca ggttcaccgc ggaagaactg ctctccgctg ggaccgagca catttccgca
    19201 ggttggccgg agaccggcac gctcgcgcct ggtgccgggg cggacctggt cacggtcgcg
    19261 acggacacgg tgcgcacggc cgggatcgaa ccgtccggcg tgctgttcgc cgccgcggcc
    19321 gcggacgtcc gtaccgtggt ggtggccggg cgggaagtgg tgcgcgacgg tgcgcacatg
    19381 ctgatcgaac gaccggaaac cttactggcc aaggagatcg aggcgctgtg gcagtactga
    19441 tcaccggaat cggcgagctc accacgaacg acccggagct gggcaagctt cgcgacgccg
    19501 cgctggtgct cgatggcgag accgtcgtgt gggcgggtcc ggccgcgcag gctccggacg
    19561 ccgacgagcg tgtcgacgtc gaaggtcgcg cggtgctgcc cgggtgggtc gacagccaca
    19621 cccatctcgt gttcgcgggg gaccgcaccg ccgagttcga ggcgcggatg gccggacagg
    19681 cttacgcggc aggcggaatc gcggtcaccg tcgacgcgac gcgggcggct tcggacgagc
    19741 agctggcggc gaacctgcgt cgacatgtcg aggaagcggc tgcgcagggc acgacctgtc
    19801 tggagacgaa gaccgggtac ggcctcaatg tcgttgacga gactcggtcg gcgcgaatcg
    19861 ctggcgaggt cgcggacgag gtgaccttcc tcggagcgca cctcgtgccg ccgggtgccg
    19921 acgcggaatc ctatgtggac ctggtctgcg gcgagatgct ggacgccgtc gcaccgcacg
    19981 tgcgctgggc cgatgtgttc tgcgagaccg gtgcgttcga cgaggcacag tcggcgcgcg
    20041 tgctcaaagc ggcggcggag cgcgggcttg ggctgcgggt gcacggcaat cagctcggcg
    20101 agggtccggg cgtgcggctg gcggtggagc tggacgcggc gagcgtggac cactgcacgt
    20161 acctgagcga tgccgacgtc gaggcgctcg cgtcgtccaa cacggtcgcg acagcgttgc
    20221 ccgcgtgcga tttgtccacg aggcaatcgc tcgctccggc acggcggctg ctcgacgccg
    20281 gcgcgacggt cgcgttggcg agcaacgcga acccgggcag ttcgtacacc acgtcgatgg
    20341 cgttctgcgt gacgacggcc gtgctgcaga tgcggatgac cgtggacgag gccgtgtggt
    20401 cggcaacggc cggcggtgcg cgggcactgc gccgggacga cgtcgggtat ctgcggccgg
    20461 gcgcgcgggc cgatgtgcat gtactcgacg cgccgtccac cacgcatctc gcttatcggc
    20521 ccggggtccc gttgacccac gcggtgtggc ggaaaggggc aaagctccgt tgatcaggtg
    20581 gcgacggcgt ccgcggctgc gctaacgtga aagggaacag gacgcgcgaa agaccattgt
    20641 ccggtatggg ttaggctgga cgacccattc gctctgtt
//
