LOCUS       NZ_CP091381            21044 bp    DNA     circular CON 18-AUG-2024
DEFINITION  Amycolatopsis sp. FU40 chromosome, complete genome.
ACCESSION   NZ_CP091381
VERSION     NZ_CP091381.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. FU40
  ORGANISM  Amycolatopsis sp. FU40
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 9944196)
  AUTHORS   Reisman,B.J. and Bachmann,B.O.
  TITLE     Biosynthesis of Apoptolidin Family Glycomacrolides
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9944196)
  AUTHORS   Reisman,B.J. and Bachmann,B.O.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-2022) Chemistry, Vanderbilt University, 1234
            Stevenson Center Drive; Room 7330, Nashville, TN 37235, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 23-JAN-2022
            Assembly Method                   :: Flye v. 2.9
            Assembly Name                     :: NFU40_flye_2.9
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 47.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_021903635.1-RS_2024_08_18
            Annotation Date                   :: 08/18/2024 04:30:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,491
            CDSs (total)                      :: 9,417
            Genes (coding)                    :: 9,360
            CDSs (with protein)               :: 9,360
            Genes (RNA)                       :: 74
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 7 of 57
            Pseudo Genes (incomplete)         :: 50 of 57
            Pseudo Genes (internal stop)      :: 5 of 57
            Pseudo Genes (multiple problems)  :: 5 of 57
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:13:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6667047
            Orig. end                         :: 6688091
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP091381.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Brian O. Bachmann,
            Vanderbilt University.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21044
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="atropopeptide"
                     /region_number="33"
                     /rules="atropopeptide_p450"
                     /tool="antismash"
     cand_cluster    1..21044
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="atropopeptide_p450"
                     /kind="single"
                     /product="atropopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21044
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11044](-)"
                     /cutoff="10000"
                     /detection_rule="atropopeptide_p450"
                     /neighbourhood="10000"
                     /product="atropopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11044)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="atropopeptide_p450"
                     /neighbourhood="10000"
                     /product="atropopeptide"
                     /protocluster_number="1"
     gene            880..1071
                     /locus_tag="L3Q65_RS31210"
                     /old_locus_tag="L3Q65_31210"
     CDS             880..1071
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1265: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020664583.1"
                     /locus_tag="L3Q65_RS31210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_31210"
                     /product="ferredoxin"
                     /protein_id="WP_182889618.1"
                     /transl_table=11
                     /translation="MRIEADLNKCDGLGMCEAMAPDFFEVGDEGTVVVLDGNPSEEHRT
                     DLAAAVDACPVLALKLVS"
     gene            1068..2282
                     /locus_tag="L3Q65_RS31215"
                     /old_locus_tag="L3Q65_31215"
     CDS             1068..2282
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010229028.1"
                     /locus_tag="L3Q65_RS31215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_31215"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_237597346.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.4e-53, bitscore:
                     181.1, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLAVVGASLAGLRAVESARRIGYDGKIVLIGAEDRLPYDRPPLS
                     KAFLAADGPAAVEPFLSADDLRELRVELRLGTPATGLDPIAREIRTGDTTVPYDATVIA
                     TGAAARVLPGTDEISGIHSLRTADDAAAIRSALDSGARTVVIGAGFIGSEVASAARKRG
                     LPVSIVETLETPLVRAIGPEVGEVCADLHRTAGTDLRLGTRVTGFTSQDGAVTGVQLST
                     GEVLPADLVVAGIGAAPATGWLRDSGLLLHERDGGVICDGTLAAAHGVYAAGDVAHVAN
                     ALFDGELMRLEHWTNAAEQGAAAARHALDPASARVFSAVPYFWSDWYSHRIQFVGTPRA
                     DEVVVAVPAEHGFTALYRRGDRLVGAFTVDRPRDIMKYRKRIAARAPWSEAVAFALETK
                     ERCVA"
     gene            2326..2949
                     /locus_tag="L3Q65_RS31220"
                     /old_locus_tag="L3Q65_31220"
     CDS             2326..2949
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013228181.1"
                     /locus_tag="L3Q65_RS31220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_31220"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_182889616.1"
                     /transl_table=11
                     /translation="MTVMSVLPVPAGGQYRQPIITAAIELTAKSGWSAVTMARLADLVG
                     VSRQTVYNEIGSKTALAEAMISHELRRFLAVVSTAFDRHPDDLVEAIYDAVRAVLELAD
                     DNILLRAIASATHGTDNEFLPLLTTRAGTLLTEAKAVLRGRVRGYAPPLDDGQLTVVMD
                     LVVRTVLSHVMQPSGTPAETADGLAWVAARVLGTAPSASMRTRS"
     gene            2992..3720
                     /locus_tag="L3Q65_RS31225"
                     /old_locus_tag="L3Q65_31225"
     CDS             2992..3720
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (23-143). E-value: 1.2e-22. Score:
                     71.5. Matches aSDomain: nrpspksdomains_L3Q65_RS31225_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005167565.1"
                     /locus_tag="L3Q65_RS31225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_31225"
                     /product="cyclopropane-fatty-acyl-phospholipid synthase
                     family protein"
                     /protein_id="WP_237597347.1"
                     /transl_table=11
                     /translation="MNRERLSALAHTRHPIAAPISDDEVQRLLARSIPREDAVVLDLGC
                     GGAEWLIRALTAYPKLRAVGVDTSEFALARARSAATERGVADRLTLHQRSATEFPAAAE
                     FDTVLCIGSTHAFGGLTDTLAALRTHVRPGGRALIGDAYGEAEPTPAALEIFGDLPDLP
                     ELLDQMVSAGWTPTHGHTSTRGELDSYEWSWTGSLTEWALDHPEDPDQAEALAAAATHR
                     DEWLRDYRHSFGFACVVLRA"
     aSDomain        3061..3420
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_L3Q65_RS31225_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="1.20E-22"
                     /label="L3Q65_RS31225_oMT.1"
                     /locus_tag="L3Q65_RS31225"
                     /protein_end="143"
                     /protein_start="23"
                     /score="71.5"
                     /tool="antismash"
                     /translation="EVQRLLARSIPREDAVVLDLGCGGAEWLIRALTAYPKLRAVGVDT
                     SEFALARARSAATERGVADRLTLHQRSATEFPAAAEFDTVLCIGSTHAFGGLTDTLAAL
                     RTHVRPGGRALIGDAY"
     gene            3780..4175
                     /locus_tag="L3Q65_RS31230"
                     /old_locus_tag="L3Q65_31230"
     CDS             3780..4175
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009083698.1"
                     /locus_tag="L3Q65_RS31230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_31230"
                     /product="VOC family protein"
                     /protein_id="WP_237597348.1"
                     /transl_table=11
                     /translation="MTDLVPFLMFQKRDAAEAMSFYTSLFPGDSVLSEERYGADGPGPE
                     GTIVMAEFTVAGQRVRCSDSFIQHGFDFTPSTSLFVTVDSTDELKRIYEALGEGGGTLM
                     PLDDYGFGPFAWVNDRWGVSWQLSAKG"
     gene            4192..4899
                     /locus_tag="L3Q65_RS31235"
                     /old_locus_tag="L3Q65_31235"
     CDS             4192..4899
                     /EC_number="2.7.7.-"
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="L3Q65_RS31235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="L3Q65_31235"
                     /product="nucleotidyltransferase domain-containing protein"
                     /protein_id="WP_237597349.1"
                     /transl_table=11
                     /translation="MDPRRREPVAAAGELARRLFADARVVIVGGSVLTDRRTATSDLDL
                     VVVTGPRDAPRRQSFTWENWPVEALVHDEETLRAYCADNLARRWPGIPRLIAEGALVAD
                     DGLGARLQTEMRQRLAAGPAAATSSELDAQRYELTDQLDDLTGADDPAEIAFIAARVLT
                     KTAQLALLAGQHWQGTGKWLWRELREHDPRLAEQLATALPDAPRLGAVARAVLDRAGGP
                     LRDGYRITDPRCP"
     gene            complement(5285..6001)
                     /locus_tag="L3Q65_RS31240"
                     /old_locus_tag="L3Q65_31240"
     CDS             complement(5285..6001)
                     /EC_number="2.7.8.-"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0016780 - phosphotransferase activity, for
                     other substituted phosphate groups [Evidence IEA]"
                     /GO_process="GO:0008654 - phospholipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020664579.1"
                     /locus_tag="L3Q65_RS31240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_31240"
                     /product="CDP-alcohol phosphatidyltransferase family
                     protein"
                     /protein_id="WP_237597350.1"
                     /transl_table=11
                     /translation="MAVSTCTRTPAELGSTVVQQAPALLAQLALLTLLTVTTGLGLAGW
                     AVGVAYLLGLLVLLTQGAWRIRVYRLGPADQVTLARAALIGTVTALVADRLGGHPALTL
                     IVPVAAVALALDALDGYVARRTGTVSALGARFDMEADAFLILVLSVLAATTVGPWVLAI
                     GLMRYAFVAAARLWPWLRAPLRPSRARKAVAALQGIALTAAVAGVAPGVLAGISVATLS
                     WSFGRDGWWLYRNRAA"
     misc_feature    complement(5834..5836)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(5980..5995)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 19.67"
                     /tool="antismash"
     gene            6035..7009
                     /locus_tag="L3Q65_RS31245"
                     /old_locus_tag="L3Q65_31245"
     CDS             6035..7009
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009083703.1"
                     /locus_tag="L3Q65_RS31245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_31245"
                     /product="zinc-binding alcohol dehydrogenase"
                     /protein_id="WP_237597351.1"
                     /transl_table=11
                     /translation="MTRAAQAFWFTSAAGGELRSAEVAAPGAGEVLVRTRFSALSRGTE
                     SLVLRGGVPESQHGIMRAPYQEGDFPWPVKYGYLNVGEVLSGPPELTGRTVFCLYPHQT
                     EYVVPASAVTVVPDDVPAARAVLAGTVETAVNALWDAAPLVGDRIAVVGAGMVGCSVAR
                     LLSRFPGVDVQLVDPDPDRAEVADAFGIRYTTPKTATGDLDLVVHASATDAGLARSLEL
                     LGNEGTVVELSWYGDRQVSVPLGENFHSRRLTVRGSQVGTVSPARAVRRGYGDRMALAL
                     RLLADPAFDALITSESTFAELPDVAARLADGTLRGLAHRITYP"
     gene            7021..7419
                     /locus_tag="L3Q65_RS31250"
                     /old_locus_tag="L3Q65_31250"
     CDS             7021..7419
                     /EC_number="4.1.2.50"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTPS"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016331711.1"
                     /locus_tag="L3Q65_RS31250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_31250"
                     /product="6-carboxytetrahydropterin synthase"
                     /protein_id="WP_237597352.1"
                     /sec_met_domain="PTPS (E-value: 1.6e-22, bitscore: 78.7,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFSVTVRDHIMVAHSFRGEVFGPAQRLHGATFVVDATFRRSELDS
                     DNIVVDIGLATQRLGAVLADLNYRNLDDEPDFAGINTSTEYLAKVIADRLADRIQAGEL
                     GENARGLAQISVTLHESHAASAGYERSL"
     gene            7416..8153
                     /locus_tag="L3Q65_RS31255"
                     /old_locus_tag="L3Q65_31255"
     CDS             7416..8153
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009083707.1"
                     /locus_tag="L3Q65_RS31255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_31255"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_237597353.1"
                     /transl_table=11
                     /translation="MTTVDSSGYAPEWLRLREPADTAARAADLVALLPAGPAVVRDLGC
                     GTGAMGRWLSGRLPKPQRWILHDQDPRLLEIAARSLPPGISVETEQADATRLNLTGTSL
                     VTASALLDLLAKEEIQRLVKSCVDAQSPALFTLSVTGSARITPADAADEALNNAFNDHQ
                     RRAGKLGPEAAAFTAAEFIRHGWTVHTRPSPWQLGPEHRELIDTWYRGFVAAAREQQPD
                     LAVPEDRQITEVTVHHQDLLALP"
     misc_feature    7779..7781
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(8136..9101)
                     /locus_tag="L3Q65_RS31260"
                     /old_locus_tag="L3Q65_31260"
     CDS             complement(8136..9101)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020664575.1"
                     /locus_tag="L3Q65_RS31260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_31260"
                     /product="DNA polymerase domain-containing protein"
                     /protein_id="WP_237597354.1"
                     /transl_table=11
                     /translation="MSKADEVREGVSLTNLDQELFADAGVTKRDLVDYFDAVSDRLLPV
                     LRDRPLSVMRVLRGQDAFMQKNLPKYTPEWVPRAKLWAESSQRTVTYGLCNDRRTLLWF
                     GNQRAVELHPALTRVDPIGQTDLIMDLDPPDGADFSVAVAAARLVRQALADAGLAGALK
                     TSGSKGVHVFVPLVPGLSFEDVAAATRAVGARAERIDPQLATTAFIREDRHGKVFLDST
                     RAGGATVAAVYSPRIRPGTPVSFPVRWADADNVTPADFTVKTAVELLGSADPWAEELPE
                     PQELPADLVAEGHTIPVARVAAMHEGKRRARARRESGESE"
     gene            complement(9179..9958)
                     /locus_tag="L3Q65_RS31265"
                     /old_locus_tag="L3Q65_31265"
     CDS             complement(9179..9958)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013230082.1"
                     /locus_tag="L3Q65_RS31265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_31265"
                     /product="oxygenase MpaB family protein"
                     /protein_id="WP_237597355.1"
                     /transl_table=11
                     /translation="MLQDGVLGVSLLAGGANVIMQLGRPAVGYGVLESRVDSGNLFKHP
                     LKRTRTTVTYLAVAVLGTDADRAAYRRAVNSVHAHVVSTEASPVRYRAFDRELQLWVAA
                     CLAHGVEDVHRVFLGRPAPESWYAEAAVLGTTLQVRPEDWPEDFAAYWADGLAQVDIDD
                     RLREYLTAIANLEFLPRPFSFLFGRFHRFVTTGFLPEVFREQMRLPWSAAQQRRFDRLM
                     RGIGRMVEPLPVRVRRFPYDACLADFRRRLRKGKPLV"
     gene            complement(10001..11044)
                     /locus_tag="L3Q65_RS31270"
                     /old_locus_tag="L3Q65_31270"
     CDS             complement(10001..11044)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     atropopeptide: atropopeptide_p450"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020639417.1"
                     /locus_tag="L3Q65_RS31270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_31270"
                     /product="cytochrome P450"
                     /protein_id="WP_237597356.1"
                     /sec_met_domain="atropopeptide_p450 (E-value: 9.4e-176,
                     bitscore: 583.0, seeds: 287, tool: rule-based-clusters)"
                     /sec_met_domain="p450 (E-value: 2.3e-13, bitscore: 48.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIPAERNKVRQVVFAPRIQELFDRYRGKSFFRLEPDTVGVAGAE
                     LMDALLRSRPPNAEERPTFKPVRGRVVTRPESSALMRAVGADVRAALKKPLGGADLAGT
                     WPATAHNYLRDLVFGREQRRFRVLVDRRLELTPKITWAAVATGAALWGRPAPEVALSTL
                     ARMVLEADTYDQRRFAMYLYRRVAGPVCFTVAALVTNALWLSSPLEDDVPTEYVLNEAL
                     RLLPPSWNILRVRSPEFTEVDARIGTGDDVLLLPLLSHRDPELWDAPDEFRPSRWAALD
                     PDTHPGYFPFGHSNERCWGRHLVLPLAERVLDLVRRDGLIVDPAQTRARVHLDGLLEVS
                     DVRVVRA"
     gene            complement(11121..11471)
                     /locus_tag="L3Q65_RS47710"
     CDS             complement(11121..11471)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038372.1"
                     /locus_tag="L3Q65_RS47710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tryptorubin family RiPP precursor"
                     /protein_id="WP_370648133.1"
                     /transl_table=11
                     /translation="MAVQRPGRARGPGAHRVCPVGALVSGEGYPRRLGLAKEFGPEFPN
                     RRPGTPEQNRSSGPFRLSCREFAEIRRTVGIGRERGRSSGEGGGISVKLVRLVRKALPG
                     KSLKSYAWYGWI"
     gene            complement(11402..12277)
                     /locus_tag="L3Q65_RS31275"
                     /old_locus_tag="L3Q65_31275"
     CDS             complement(11402..12277)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009083714.1"
                     /locus_tag="L3Q65_RS31275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_31275"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_237597357.1"
                     /transl_table=11
                     /translation="MELHQLEYFVAVAEEANFTRAAARMHVAQPGVSAQIRRLERELGQ
                     PLFDRSGRTVRLTGVGEAALPHARAALAAVAAVRETVAEHEGLVRGQVAMGMVTSLGPV
                     ELPEFLAGFAERYPGVEITLSEANSDLMIEALREGRMDVAVIGLADGVPAGLTAQIVLD
                     EELVAVTAPRDEFADRTSLTLADLAERSLICLPKGTGMRGVLDRGFAAAGLRSRVTIEA
                     SDPNVLAKLAMRGLGVALVPRSLARYYAEELHTLRLRPELRGQLALAWRSNGPAGPAAR
                     ALIEFAQSAL"
     gene            12348..13490
                     /locus_tag="L3Q65_RS31280"
                     /old_locus_tag="L3Q65_31280"
     CDS             12348..13490
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138: FAD linked oxidase domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009083715.1"
                     /locus_tag="L3Q65_RS31280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_31280"
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_182889606.1"
                     /transl_table=11
                     /translation="MQTFTPDQAGYRDEIAGFQTGITSTPQLVVAATSADDVAAAVRLA
                     AERDLPVSVQATGHGLRAPAEGVLISTRRMTGVTIDPDRKAARVEAGTTWGSVITAAAE
                     HGLAPLSGSAPGVGVVGYTLGGGFGLLGRHFGLASDRVRSAEIVRPDGRRTTGPIDAGI
                     VTSLEFELVPVTTLYGGGLYFDTAKIPDVLRTWRDWTLDLPDTVGTSVAMVPYPNLPMV
                     PEPLRGKHIAHIRVAYPGIGGDELVAPLRALGPLQETLTTMPFTDSGKIAAEPPNPHSY
                     LGDNRVLPELRDDVLSTVLDHAGPDAPVPTVLIIDLLGGAYRHSSAPDFTADSRYTVRA
                     LSMIEPDAATVRAAHAKLFAPLDPMSTGRLRSFVYGQPLD"
     gene            complement(13492..13896)
                     /locus_tag="L3Q65_RS31285"
                     /old_locus_tag="L3Q65_31285"
     CDS             complement(13492..13896)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009083716.1"
                     /locus_tag="L3Q65_RS31285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_31285"
                     /product="nitroreductase family deazaflavin-dependent
                     oxidoreductase"
                     /protein_id="WP_037811027.1"
                     /transl_table=11
                     /translation="MSDWNQQIIDEFRANAGKVGGMFEGKNMVLITHTGAKSGKQRVSP
                     LVYTTDGDRIVIVASKGGADTNPDWYHNLVANPAVTVEIGTDKFPAKAKLVTDRAERDR
                     LYAKMVEHAEGFAEYEKKTERLIPVFVLER"
     gene            13983..14432
                     /locus_tag="L3Q65_RS31290"
                     /old_locus_tag="L3Q65_31290"
     CDS             13983..14432
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020664570.1"
                     /locus_tag="L3Q65_RS31290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_31290"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_182889605.1"
                     /transl_table=11
                     /translation="MATESGPTVEDGVRELLLLMPRLVGRAKRTPPPPELDDVALAPRH
                     LSLLAYLLFDGPMTVNELAGRLEIAPTTASLMIGDLSRQGVLERAEDPDDRRRTIVSIH
                     ADKRPAVDAWLARGAKAWEAALAPLSPGERAVVIRTLRAYEEYGS"
     gene            complement(14465..15079)
                     /locus_tag="L3Q65_RS31295"
                     /old_locus_tag="L3Q65_31295"
     CDS             complement(14465..15079)
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020641545.1"
                     /locus_tag="L3Q65_RS31295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_31295"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_237597358.1"
                     /transl_table=11
                     /translation="MAKRTCDRRGHAFAFGRFLFRTPTAWEYAAAVAGGSDPAAQRWLG
                     WLPDSVVAEPMRGEALRVIPGTGPDWTTPDPHSVDVVAIDLVAGRCAGLVSVHAGEDGG
                     PETGGYLAPGYRGQGFGRDLFAAGLVLAHEHLGLSRVRAGAEVGNVASGRSLEAAGLRR
                     VPGPPQYTLPDGRACEAWWYQHDAAWPRKCAGPQAQWLVAS"
     misc_feature    15066..15078
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.65"
                     /tool="antismash"
     gene            15282..16130
                     /locus_tag="L3Q65_RS31300"
                     /old_locus_tag="L3Q65_31300"
     CDS             15282..16130
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009083718.1"
                     /locus_tag="L3Q65_RS31300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_31300"
                     /product="PaaX family transcriptional regulator C-terminal
                     domain-containing protein"
                     /protein_id="WP_237597359.1"
                     /transl_table=11
                     /translation="MTAVPEAADADGGRATQPRHLIVSVYGVHHQAGGEWLSVASLIDL
                     LAAVGVDEPAVRSSISRLKRRGVLEAVRRDGAAGYELSGTALDLLREGDERIFRRDRAK
                     LADGWLLAVFSVPEAERHKRHVLRTQLSRLGFGTASSGVWIAPAHLYEVTVGTLERLGL
                     AEYADLFRAEHLAFGDPREKVREWWDLDQLNELYTAFLEEHEPALRRWQRRRTTPADEA
                     FADYLRVLTGWRRMPYLDPCLPAELLPEGWSGIRAAEVFFTLHDRLEEAARTHLRQVLS
                     G"
     gene            complement(16120..16512)
                     /locus_tag="L3Q65_RS31305"
                     /old_locus_tag="L3Q65_31305"
     CDS             complement(16120..16512)
                     /EC_number="3.5.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009083722.1"
                     /locus_tag="L3Q65_RS31305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_31305"
                     /product="RidA family protein"
                     /protein_id="WP_182889602.1"
                     /transl_table=11
                     /translation="MERINPPELGKPSGFSHAVAAQGRLVFLAGQTALDADNRIVGDGV
                     VEQFERALGNLLTALRAAGGEPADLCGLTVYIVDMDDYQAHAREIGRVWKRLVGADYPA
                     MAGIGVNRLWDVEALVEVQGYAVVNR"
     misc_feature    16532..16547
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.4"
                     /tool="antismash"
     misc_feature    16532..16552
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.78"
                     /tool="antismash"
     gene            16580..18931
                     /locus_tag="L3Q65_RS31310"
                     /old_locus_tag="L3Q65_31310"
     CDS             16580..18931
                     /GO_function="GO:0003959 - NADPH dehydrogenase activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016337430.1"
                     /locus_tag="L3Q65_RS31310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_31310"
                     /product="bifunctional salicylyl-CoA
                     5-hydroxylase/oxidoreductase"
                     /protein_id="WP_237597360.1"
                     /transl_table=11
                     /translation="MRISVVGGGPAGLYFAVLAKQLGPDHEITVWERNAPDDTFGFGVV
                     FSDETLGGIEHADSAVHEAMSQEFARWDDIDVHYRGTVSTSGGHGFAAMSRKRLLAILQ
                     QRCREMGIDVRFRSVAPDPAELAASSDLVVAADGVNSAVRTAFADSFRPSVETRQCRYL
                     WLGTDLVFDAFKFYVLETPHGIMQVHGYPYGRDGSTFILEMHDDVWQQAFGPIAATGLG
                     PGESDEKSIELIRELCGDIFDGHQLLANNSKWATFGTVRCESWVHDNVVLLGDAAHTAH
                     FSIGSGTKLAMEDALALAACLHEQPSVPEALAAYEEERRPVVASTQRAAQASLEWFENL
                     AQYTHQEPEQFAFNLLTRSRRVTYDNLKLRDKEFAASLDQWFADSLGTSVAPPMFQPVR
                     IGSLELPNRIIVSPMDMYSAVDGVPGEFHLVHLGSKALGGAGMVMTEMICVSAEGRITP
                     GCPGLYTSGQEAAWQRIVEFVHRETPAKIGLQLGHSGRKGSTKLMWEGIDDPLPEGNWE
                     VCAPSALPYSPNNQTPRELSVAELGEIRDQFVSAAEAAARAGFDLLELHCAHGYLLSSF
                     LSPLTNHRTDSYGGSPENRLRFPLEVFDAVRAVWPADRPLTVRISATDWFEGGNDADEA
                     VAIAQAFAEHGAAAIDVSTGQVVSEEKPKFGRSYQTPYADRIRNEVGRRYGTAVIAVGA
                     ISSYDDVNSLILAGRADLCALGRTHLFNPQWTLHAAAAQEYPVAWPKQWAAGKRPPQTG
                     RTDGPEPRLDLVRTGGHQTAHARWRPEDAR"
     gene            18928..20073
                     /locus_tag="L3Q65_RS31315"
                     /old_locus_tag="L3Q65_31315"
     CDS             18928..20073
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009083725.1"
                     /locus_tag="L3Q65_RS31315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_31315"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_237597361.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2.9e-12, bitscore:
                     46.3, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 2.2e-23, bitscore:
                     81.3, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.4e-48, bitscore:
                     164.0, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNAFAFTPEQTAYSASVRKIAAEQLVDLAAAGAEGAVNRPLLKAM
                     GAHGLLARLFPGVESGQPTRQAAATDLCLLREALATQSTEAETALALQGLGSYPVLQSG
                     LDEQVQRWLPAVAAGDAVAAFALTEPDAGSDAAALQLAAEPDGDGWRLTGTKMWISNAP
                     EADFYTVFARTTPDAGARGVSAFVVPGDRAGLSGEHLDLVSPHPIGTVVFDGVRVNLDE
                     LLGEENRGFAVAMRTLDLFRPSVGAFAVGMAQAALDATVEYTASREAFGGPLVKQQTVA
                     HTLAEMATRTEAGRLLVYAAAAAYDAGEQNLAGRAAMAKLFATETAQYVVDQAVQLHGA
                     RALRRGHLLEHLYREVRAPRIYEGASEIQRTIIARSLQRRG"
     gene            complement(20171..20899)
                     /locus_tag="L3Q65_RS31320"
                     /old_locus_tag="L3Q65_31320"
     CDS             complement(20171..20899)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098058.1"
                     /locus_tag="L3Q65_RS31320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_31320"
                     /product="DUF2306 domain-containing protein"
                     /protein_id="WP_182889599.1"
                     /transl_table=11
                     /translation="MTAGTDLRPPRVPPAADRTKRVEPKKHWWRRPWVGPLGLVVVAFL
                     AYSLPPYLAFDPARSRVPSTFPAHYLFLVGHVVFGSVAMVTAALQIWPWIRRKYPVLHR
                     CSGRAYVFAGVLPSGLLALTIGAATPFGPVTRASDVLLAVVWLGTTWAGYRAARERRFG
                     DHRRWMVRSFALTMSIILNRLIGPIAAIFLEPQLATTFGGSEIALGQSIAALGAWVSWT
                     VALIAAQLWLDRKPNRRASV"
ORIGIN
        1 ccacgtgcgc gtcgcgactc cggaggaccc ggcgtcgagc cgtgttggcg agagcttcta
       61 ccggttctgg ccgcgtacgg tgttcggctc gctgaaatcc gcgtggggac tggagcgcaa
      121 gcgttacgcc cgtcgcgaca agcatccgtt ccggatcggc aatgacgtgc tcaacgcgtg
      181 gctgatgtcc gcggtgctgt gggtggcgat ggtggcctgg ctcggtgtcg ggatcctgcc
      241 gtacctggtg atccaggcgg tgatcgggtt ctcgctgctg gaagtcgtga actacatgga
      301 gcactacggg atgctgcggc agaaggtcgg gccgccggag cgccgtcgct acgagcgcgt
      361 ggatcccagc cacagctgga attccaacaa catcgcgacc aacgtcctgc tgtaccacct
      421 gcagcggcac agcgatcacc acgccaaccc gacgcgccgc taccagaccc tgcgcgactt
      481 cgccgaatct ccggtgctgc cgaccgggta cgccgggatg atcgtgctcg cgctgttccc
      541 gccgctgtgg cggcgagtga tggaccagcg ggtgctcaac cacttcgacg gcgacatcag
      601 ccgggcgaac atccagccgt cgaagcggga gaaaatcctt gcccggtatg gctcttcggc
      661 tcacgaggcg gtttccgtgc cggaagacgt gcgcggcgac gccagcgaag gcgggatgtg
      721 ccccggttgc ggatacgtgt acgacgagca gcgcggcgac ccgcgtgaag gcttcccggc
      781 cggtacgccg tggtcatcca ttccggacag ttggtgctgt cccgactgcg gcgtaaggga
      841 aaaggtcgac ttcgttgctc ccggaaggat gagtgtctga tgcggatcga agcggatttg
      901 aacaagtgtg acggcctggg catgtgcgaa gcgatggccc cggacttctt cgaggtgggc
      961 gacgagggca cggtcgtggt gctcgacggc aaccccagcg aggagcaccg gaccgatctc
     1021 gccgcggcgg tcgacgcctg cccggtgcta gcgctgaaac tggtgtcatg acgctcgcgg
     1081 tggtgggcgc gtcgctggcg ggactgcgag cggtcgaatc ggcgcggcgg atcggatacg
     1141 acgggaagat cgtgctgatc ggcgcggagg accgtctgcc gtacgaccgg ccgccgctgt
     1201 cgaaggcctt cctcgcggcg gacggaccgg ctgcggtgga gccgtttctc agcgcggacg
     1261 acctgcgcga gctccgcgtc gaactccggc tgggcactcc cgcgaccgga ctcgacccga
     1321 tcgccaggga gatccgcacc ggcgacacga ccgtcccgta cgacgcgact gtcatcgcca
     1381 ccggagccgc cgcccgcgtt ctccccggca ccgacgagat ctccggcatt cactcgctgc
     1441 gcaccgcgga cgacgccgcg gccattcggt ccgcattgga cagtggtgct aggacagtcg
     1501 tgatcggtgc cgggttcatc ggatcggaag tcgcttcagc cgcacgcaaa cgcggcctgc
     1561 cagtgtccat tgtggaaaca ctggaaacgc cgttggtccg cgcgatcggc cccgaagtcg
     1621 gcgaggtctg cgcggatctg catcgcacgg caggcaccga tctccggctg ggcaccaggg
     1681 tcaccggctt cacgtcgcag gacggtgcgg tgaccggcgt ccagctgtcc accggcgaag
     1741 tcctcccagc cgacctcgtg gtcgccggaa tcggcgcggc cccggccacc ggctggctgc
     1801 gcgacagcgg acttctgctg cacgaacgcg acggcggcgt catctgcgac ggcaccctcg
     1861 ccgccgcaca cggcgtttat gcggccggag acgtcgcaca cgtggcgaac gcgctgttcg
     1921 acggcgaact gatgcggctg gaacactgga cgaacgcggc cgagcagggt gccgccgcgg
     1981 cgcggcacgc gctggaccca gcgagtgccc gggtgttcag cgccgtgccg tacttctggt
     2041 ccgattggta ctcgcaccgc attcagttcg tcggaacgcc gcgcgcggac gaggtcgtcg
     2101 tcgcggtccc ggcggagcac ggcttcaccg cgctgtaccg ccgcggcgac cggctcgtcg
     2161 gcgcgttcac cgtcgaccgg ccgcgcgaca tcatgaagta ccgcaaacgg atcgccgcgc
     2221 gagcgccgtg gtccgaggca gtcgccttcg cgctggaaac aaaagaacgc tgcgtggcgt
     2281 agccactcgg ttgagggcgg tggaggggag gaaggtggag ataagatgac ggtcatgagc
     2341 gtgcttccgg tgcccgcggg cggccagtac cggcagccca tcatcaccgc cgccatcgaa
     2401 ctcaccgcga aatccggctg gtcagcggtc accatggcgc gcttggccga tctggtcggg
     2461 gtgagcaggc agaccgtcta caacgagatc ggctcgaaaa ccgcgctcgc cgaggcgatg
     2521 atctcgcacg agctgcgccg gttcctcgcg gtcgtgagca ccgcgttcga ccggcatccg
     2581 gacgacctgg tcgaggcgat ctacgacgcc gtccgcgcgg tgctcgaact ggccgacgac
     2641 aacatcctgc tgcgcgccat cgcctccgcg acacacggca ccgacaacga attcctgcca
     2701 ctgctgacca cccgcgccgg caccttgctc accgaagcga aagccgtcct gcgcggccgg
     2761 gtccgcggct acgcgccgcc actcgacgac ggccagctca ccgtggtcat ggacctcgtc
     2821 gtgcgcaccg tgctcagcca cgtcatgcag ccctcaggca cccccgccga aaccgccgac
     2881 ggcctggcct gggtcgccgc gcgcgtgctc ggcaccgccc cgtcggcctc gatgcgcacc
     2941 cgctcgtaaa caagatgcgc ggtcctgcgc gcacgtgtca gcgtggcgcg cgtgaaccgt
     3001 gaacgacttt ccgcactcgc ccacacccgg caccccatcg ccgccccgat cagcgacgac
     3061 gaggtccagc gcctgctcgc tcgcagcatc ccgcgcgagg acgctgttgt cctggacctg
     3121 ggctgcggtg gtgccgaatg gctcatccgc gccctcaccg cgtacccgaa gctccgcgcg
     3181 gtcggcgtcg acacctcgga attcgccctc gcccgcgccc gctccgcggc gaccgaacga
     3241 ggcgtcgccg accgcctgac cctccaccag cgctccgcca ccgaattccc cgccgcagcc
     3301 gagttcgaca ccgtcctgtg catcggctct acccacgcct tcggcgggtt gacggacacc
     3361 ctcgccgcac tgcgaaccca cgtccgccct ggcggccgcg ccctgatcgg cgacgcctac
     3421 ggggaagccg agccaacccc cgccgccctc gagatcttcg gcgacctgcc agacctgccg
     3481 gaactgctcg accagatggt ttccgccggc tggacgccga cccacggcca caccagcacc
     3541 cgcggcgaac tggactccta cgaatggtcg tggaccggca gcctcaccga gtgggccctc
     3601 gaccacccgg aagacccaga ccaggccgaa gccctcgccg ccgcggccac ccaccgcgac
     3661 gagtggctcc gcgactaccg gcattcgttc ggcttcgcgt gcgtcgtgct gcgcgcttga
     3721 caaaacttct tgtcaatgcc acgttcggac ctgaacccaa cccgcgaaag ggcagtccga
     3781 tgaccgatct cgtcccgttc ctgatgttcc agaagcgcga cgccgccgag gcgatgtcct
     3841 tctacacctc gctgttcccc ggcgactccg tgctgtccga ggagcgctac ggcgccgacg
     3901 gccccggccc ggagggaacg atcgtgatgg ccgagttcac cgtcgccggg cagcgagtgc
     3961 ggtgcagcga cagcttcatc cagcacggct tcgatttcac gccgtctacc tcgctgttcg
     4021 tcacggtgga ctcgactgac gaactcaagc ggatctacga ggcactcggc gagggcggcg
     4081 gaaccctgat gccgctcgac gattacggct tcggcccgtt cgcctgggtg aacgaccggt
     4141 ggggcgtgtc gtggcagttg agtgcgaagg gctgaggcac tgaaccgagc gatggacccg
     4201 cgcaggcgcg agccggttgc cgccgccggc gagcttgccc gtcggttgtt cgcggacgcc
     4261 cgggtcgtga tcgtcggcgg cagtgtgctg accgaccggc gcacggcgac gtccgatctc
     4321 gacctcgtgg tggtcaccgg accccgcgac gccccgcgcc ggcagtcgtt cacctgggaa
     4381 aactggcctg tggaagcact ggtgcacgac gaagaaacct tgcgcgccta ttgcgccgac
     4441 aatctggccc gccgctggcc aggcatcccc cggctcatcg ccgagggagc gctcgtggcc
     4501 gacgacggcc tcggcgcccg gctgcaaacc gagatgcggc aacgcctggc cgcgggaccc
     4561 gccgccgcga cgtcaagcga actcgacgcg cagcgatacg aactcaccga ccagctcgac
     4621 gacctgaccg gagccgacga cccggccgag atcgccttca tcgccgcccg ggtgctgacc
     4681 aagacagcgc aactcgccct gctggccggt cagcattggc aaggcaccgg caaatggctg
     4741 tggcgcgaac tgcgcgagca cgatccccgt ctggccgaac agctggccac tgccttgccg
     4801 gacgcgcctc ggctcggcgc ggtcgcccgt gcggtgcttg accgcgctgg cggaccgctg
     4861 cgggatggat accggatcac cgatccccgt tgtccttgac cgcggagtgg ccagcaagat
     4921 acgtgtacgg tttctttttg cgatcgctaa tcgctgcgga tccgcagctc gagagcaatt
     4981 ccgcccacta ttgacgtgac gccagatacc gcgaagagaa atacgacccg gtgacccacg
     5041 gacgggttaa gcagtgctat tcagaccccg ctatggtggg cattgggagg ttggcaatca
     5101 gcctgagggg ggccgatacc gcatcccggg gccagccgct tcacctgcag tagttccgct
     5161 tggacggcac tgcgcggggc aagcggctgg cccttgtgcc gtacttcgaa atcaagagcc
     5221 acgacagtgt ttccgacacc gaaacgttga ggccagaaga atcgccgcaa cggaattcgc
     5281 gaacctaggc ggcacggttc cggtacagcc accacccgtc gcggccgaat gaccagctca
     5341 gcgtcgccac cgaaataccc gccaagaccc ccggtgcgac tcccgcaacc gcagcggtca
     5401 gggcgattcc ctgcaaagcc gccactgcct tccgggcccg gctggggcgc agcggggcac
     5461 ggagccacgg ccacagccgg gccgcggcga cgaaggcgta ccgcatcagg ccaatcgcca
     5521 ggacccacgg gccgaccgtg gtggcggcca ggacactcag caccaggatc aggaaagcgt
     5581 ccgcttccat gtcgaagcgg gcgcccagcg cggagacggt accggtgcgg cgggcgacgt
     5641 atccgtcgag tgcgtccagg gccagggcga ccgcggcgac ggggacgatc aaggtcagcg
     5701 ccgggtgccc gcccaggcgg tcggcgacca gggcggtcac ggtgccgatc agggccgctc
     5761 gggcgagggt cacctgatcg gcggggccca ggcggtacac ccggattcgc caggcaccct
     5821 gggtgagcag cactaacagg ccgaggaggt acgccacgcc gactgcccag ccggccaagc
     5881 cgaggccggt cgtgaccgtc agcagggtca gcagggcgag ttgcgccagc agcgcggggg
     5941 cctgctggac gaccgttgaa cccagctcgg ccggggttcg tgtacaggtg gagacagcca
     6001 tttctcctcg atccggcagc aacggaggac aaccttgaca cgggcggcgc aggccttctg
     6061 gttcacttcg gccgcgggcg gggagctccg atcggccgag gtggctgctc cgggagccgg
     6121 cgaagtgctg gtccgaacgc gtttttcggc gttgagccgc ggcacggaaa gtctcgtgct
     6181 gcgcggcggg gtgccggaga gccagcacgg catcatgcgc gcgccgtatc aggagggcga
     6241 ctttccgtgg ccggtcaagt acggctacct gaacgtcggc gaggtccttt ccggaccgcc
     6301 ggagctgacc ggccgcacgg tgttctgcct ctatccacat cagaccgagt acgtggtgcc
     6361 cgcgtcggcg gtcacagtgg tgccggacga cgtccccgcg gcgcgggcgg tgctcgccgg
     6421 gacggtcgag accgcggtga acgcgctctg ggacgcggca ccgctggtcg gcgaccggat
     6481 cgcagtggtc ggggcaggga tggtcggctg cagtgtcgcg cggctgctgt cccggtttcc
     6541 cggcgttgac gtacagctcg tcgaccccga tccggaccgc gcggaggtcg cggacgcgtt
     6601 cggcatccgt tacaccaccc cgaaaaccgc gactggcgac ctcgacctcg tggtgcacgc
     6661 cagcgcgacc gacgccgggc tcgcgcgttc gctggaactc ctcggcaacg agggcacggt
     6721 ggtcgagctg agctggtacg gcgaccgtca ggtgtcagtg ccgctcggag agaacttcca
     6781 ttcgcgacga ctcactgtgc gcggcagcca ggtcggtacc gtctcgccgg ctcgcgcggt
     6841 gcggcgcggt tacggcgacc ggatggcgct ggcgttgcgg ctgctcgcgg acccggcgtt
     6901 cgacgcgctg atcaccagcg aatccacctt cgccgaactg ccggacgtcg cggcgcggct
     6961 agcggacgga acgctgcgcg gactggctca ccggatcacc tacccgtaaa ggagaacgcg
     7021 ttgttcagtg tcaccgtgcg cgatcacatc atggtcgccc acagtttccg cggcgaggtt
     7081 ttcggcccgg cgcaacgctt gcacggcgcg acgttcgtgg tcgacgcgac gttccggcgg
     7141 tccgaattgg actcggacaa catcgtcgtc gacatcgggc tcgcgactca gcggctcggc
     7201 gcagtgctcg ctgacctgaa ctaccggaat ctggacgacg aacccgattt cgccgggatc
     7261 aacacgtcga cggaatacct cgccaaggtg atcgccgacc ggctcgcgga ccggatccag
     7321 gccggggaac tcggcgagaa cgcccgcgga ctggcccaga tttcagtgac cctgcacgaa
     7381 tcccacgccg cttcggccgg atacgagcgc tccttgtgac cacagtggac tcttccggtt
     7441 acgcgccgga atggctgcgg ctcagagagc cagccgacac cgcggcccgg gcggccgatc
     7501 tggtcgcctt gctcccggcc ggcccggcgg tcgtgcgcga cctcggctgc gggaccgggg
     7561 cgatgggacg gtggctgtcc ggccggcttc cgaaaccgca gcggtggatt ctgcacgacc
     7621 aggacccgcg gctgctcgag atcgccgcac gcagtcttcc gccggggatc agcgtcgaga
     7681 cggagcaagc cgatgcgact cggctgaatc tgaccggcac ttctttggtg acagcttccg
     7741 cgctgctgga tctccttgcc aaggaggaga tccagcgatt agtgaagtcc tgtgtggacg
     7801 cacaaagccc ggcactgttc acgttgtccg tgaccggatc ggctcgaatc acgccggcgg
     7861 acgcagcgga cgaagcactc aacaacgcct tcaacgacca ccaacgccgc gccggaaagc
     7921 taggcccaga agccgccgcc ttcaccgcgg cagagttcat aaggcacggc tggaccgtcc
     7981 acaccagacc gtcaccgtgg cagctcggcc cggaacaccg cgaactcatc gacacctggt
     8041 accgcggatt cgtcgccgcg gcacgagaac agcaacccga cctggcggta cccgaggatc
     8101 ggcagatcac cgaggtcacc gtgcaccacc aggatctact cgctctcccc tgattcccgg
     8161 cgcgcccggg cccggcgttt gccctcgtgc atcgccgcga cccgggcgac cgggatcgtg
     8221 tgcccctcgg cgacgagatc cgccggaagt tcctgcggtt ccggcaattc ctccgcccac
     8281 ggatcagcgc tgccgagtag ctccaccgcg gtcttcaccg tgaaatccgc cggtgtgacg
     8341 ttgtccgcat cggcccagcg gaccgggaac gacaccggtg tgcccggccg gatccgcggg
     8401 ctgtaaaccg ccgccacggt cgcccctccc gcacgggtcg aatcgagaaa caccttgccg
     8461 tgccggtctt cccggatgaa cgccgtggtc gccagctgcg gatcgatccg ttccgctcgc
     8521 gctccgaccg cccgggtcgc cgccgcgacg tcctcgaaag acagaccggg aaccagcggc
     8581 acgaacacgt gcacgccctt ggacccgctg gtcttcaacg caccggcgag cccggcgtcg
     8641 gccaacgcct gccgcaccag ccgagccgcc gccaccgcga cgctgaagtc cgcgccgtcg
     8701 ggcggatcga ggtccatgat cagatcggtc tggccgatcg gatccacccg ggtcagcgcg
     8761 ggatgcaatt cgaccgcgcg ctggttgccg aaccacagca gcgtccggcg gtcgttgcac
     8821 aggccgtagg tgactgtccg ttgtgaactc tccgcccaca gtttcgcccg cggcacccac
     8881 tccggcgtgt atttcggcag gttcttctgc atgaacgcgt cctgtccgcg cagcacgcgc
     8941 atcaccgaca gcggacgatc gcgcagcacc ggcagcaacc ggtccgaaac ggcgtcgaag
     9001 tagtcgacga ggtcgcgctt ggtcaccccg gcgtcggcga acagctcctg gtcaaggttg
     9061 gtcagggaaa ccccttcgcg cacctcatcc gctttgctca tgctgcctcc gcggcagaaa
     9121 gtacgtcggc agtggccatc cgccaaccct tgccgaccgg cgcagtccgg tcaaccgctt
     9181 agacgagcgg ttttcctttc cgcaaccgcc gccggaagtc cgcgaggcac gcgtcataag
     9241 ggaaacgccg cacccgcacc ggaagcggtt cgaccattcg gccgatcccg cgcatcagcc
     9301 gatcgaaccg gcgctgctgc gcggccgacc acggcagccg catctgctcg cggaacactt
     9361 ccggcaggaa gccggtcgtg acgaagcggt ggaaccgtcc gaagaggaac gagaacggcc
     9421 gcggcaggaa ttccagattc gcgatggcgg tgaggtactc gcggagccgg tcgtcgatgt
     9481 ccacttgggc cagtccgtcc gcccagtacg cggcgaagtc ctccggccag tcttccggac
     9541 gcacctgcag cgtcgtgccc agcaccgcgg cctcggcgta ccacgattcc ggagcgggcc
     9601 ggccgagaaa cacgcgatgc acgtcctcga cgccatgggc cagacaggcg gcgacccaca
     9661 gctgcagctc ccggtcgaaa gcccggtacc gcaccggact cgcctcggtc gagaccacgt
     9721 gtgcgtgcac cgaattcacc gctcgccggt acgccgcccg gtccgcgtcg gtgcccagca
     9781 cggcgaccgc gaggtaggtg acggtggtgc gcgtgcgttt cagcggatgc ttgaacagat
     9841 tccccgagtc gacccggctt tccagcacgc cgtacccgac cgcgggccgg cccagctgca
     9901 tgatcacgtt cgcgccgccc gcgagcaggc tgacgccgag cacgccgtcc tggagcatcc
     9961 gtccagggga acgcctccgt tgacacgttg tcaagagctc tcaggcacgc acgacccgca
    10021 cgtccgaaac ctccagcagc ccgtccaggt gcacccgggc ccgcgtttgc gccggatcga
    10081 cgatcagacc gtcgcgccgg accaggtcga ggacgcgttc cgccagcggc agcaccaggt
    10141 gccgtcccca gcagcgttcg ttgctgtgcc cgaacgggaa gtagccgggg tgggtgtccg
    10201 ggtcgagcgc ggcccagcgg ctcggccgga actcgtcggg cgcgtcccac agttcggggt
    10261 cgcggtggct gagcagcggc agcagcagga cgtcgtcgcc agtgccgatc cgggcgtcca
    10321 cctcggtgaa ctccggcgaa cgcacgcgca ggatgttcca cgacggcggc aggaggcgca
    10381 gtgcctcgtt gagcacgtac tcggtcggca cgtcgtcctc cagcggagaa ctgagccaca
    10441 gggcgttcgt gaccagcgcg gcgacggtga agcagaccgg accggccacg cgccggtaga
    10501 ggtacatcgc gaagcggcgc tggtcgtagg tgtccgcttc cagcaccatc cgcgccaaag
    10561 tggacagcgc gacctcgggc gcgggccgtc cccagagcgc ggctccggtg gcgaccgccg
    10621 cccaggtgat cttcggtgtc agctccaacc ggcggtcgac gagaacccgg aaccgccgct
    10681 gttcgcggcc gaacaccagg tcacgcaggt agttgtgcgc cgtggcgggc catgtcccgg
    10741 cgaggtcggc cccgccgagc ggctttttga gcgcggcacg cacgtccgcg ccgaccgcgc
    10801 gcatcagcgc cgacgattcc ggccgcgtga ccacccggcc gcgcaccggc ttgaacgtcg
    10861 gccgctcctc ggcgttcggc ggcctgctgc gcagcagcgc gtccatcaac tcggccccgg
    10921 cgacgccgac agtgtccggt tccagccgaa agaaggattt cccccgataa cggtcgaaca
    10981 gttcttgaat acgcggcgcg aataccacct gccgcacttt gttccgttca gcgggaatgg
    11041 tcacgcacaa ctcctcttga gcggcaaacc ggccggttcc ggggaattcc gaaaccggcc
    11101 ggtcccgttt aacgggacgg tcagatccag ccgtaccagg cataagactt caggctcttg
    11161 cccggaaggg ccttgcgcac gagacgaaca agcttcacgg aaatacctcc gccttctccg
    11221 gaacttcgac cgcgctcgcg gccgattccg acagtacgac gaatttccgc gaattcgcgg
    11281 caagacaacc tgaacggccc actcgaccgg ttctgttcgg gagttcccgg tcgtcgattc
    11341 gggaattccg gcccgaattc cttggcgagt ccgaggcggc gtgggtatcc ttcgccgctc
    11401 actagagcgc cgactgggca aactcgatga gcgcccgggc cgcgggcccg gccgggccgt
    11461 tggaccgcca cgccagcgcc agctgcccgc gcagttccgg ccgcagccgc agggtgtgca
    11521 gttcctcggc gtagtaccgg gccagcgatc gcgggaccag cgccaccccg aggccgcgca
    11581 tcgccagctt ggccagcacg ttcgggtcgc tcgcctcgat cgtcacccgc gaacgcagcc
    11641 cggccgcggc gaacccgcga tccagcacgc cccgcatacc ggtgcccttc ggcaggcaga
    11701 tcagcgaccg ttcggccagg tcggcgaggg tgagcgaagt acggtcagcg aattcgtcac
    11761 gcggcgcggt gaccgcgacc agctcctcgt cgagcacgat ctgagcggtc agcccggcag
    11821 gcacgccgtc ggcgaggccg atcaccgcga cgtccatccg gccctcgcgc agcgcctcga
    11881 tcatcagatc ggaattcgct tcgctgagcg tgatttccac ccccgggtac cgctctgcga
    11941 acccggccag gaactccggc agctccaccg gcccaagaga agtcaccatc cccatcgcca
    12001 cctgcccgcg caccagcccc tcgtgctcgg cgaccgtctc gcgcaccgct gccaccgccg
    12061 cgagcgcggc ccgggcgtgc ggcagcgcgg cctcgccgac gccggtgagc cgtaccgtgc
    12121 gcccggaccg gtcgaacagc ggctgcccca gctcccgttc cagtcgccgg atctgcgcgc
    12181 tgaccccggg ctgcgcgacg tgcatccggg ccgccgcgcg cgtgaagttg gcttcctccg
    12241 cgaccgcgac gaagtactcg agctgatgca gttccataac cagtaattct agctgctgga
    12301 actagtatct cttggactta tcactgaaac gccagcacgc tgatggcatg cagacgttca
    12361 cccctgacca ggccggttac cgcgacgaga tcgccgggtt ccagaccggc atcacctcaa
    12421 ccccgcaact ggtcgtcgcc gccaccagcg cggacgacgt cgccgccgcg gtccggctcg
    12481 cggccgagcg cgacctgccg gtttccgtgc aggcgaccgg ccacgggctg cgcgcgcctg
    12541 ccgagggcgt gctgatctcg acgcgccgga tgaccggcgt gaccatcgat ccggaccgca
    12601 aggcggcccg cgtcgaagcc ggaaccacct ggggcagcgt catcaccgcg gccgcggagc
    12661 acgggctcgc gccgctgagc ggttcggccc ccggcgtcgg cgtggtcggc tacaccctcg
    12721 gcggcggttt cggtctcctc ggccggcact tcggactggc ctcggaccgc gtccgctccg
    12781 ccgagatcgt ccgtcccgac ggcaggcgca cgaccggtcc gatcgacgcc gggatcgtga
    12841 cctcgctgga gttcgaactg gtgccagtga ccacgcttta cggcggcgga ctgtacttcg
    12901 acaccgccaa gatcccggac gtcctgcgca cctggcgcga ctggaccctc gacctgccgg
    12961 acaccgtcgg cacctcggtc gcgatggtgc cgtacccgaa tctgccgatg gtgccggaac
    13021 cgttgcgcgg caagcacatc gcgcacatcc gcgtggctta tcccggcatt ggcggagacg
    13081 agctcgtcgc gccgctgcgt gccctcggcc cgctccagga aacgctgacc acgatgccgt
    13141 tcaccgattc cgggaagatc gccgcggaac cgccgaaccc gcactcgtac ctcggcgaca
    13201 accgcgtgct gccggagctc cgggacgacg tgctgagcac tgtgctcgac cacgccggcc
    13261 cggacgcccc ggttccgact gtgctgatca tcgatctgct cggcggcgcg taccggcact
    13321 catccgcacc ggacttcacc gctgattcgc gctacaccgt gcgcgcgctg tcgatgatcg
    13381 aaccggacgc ggcgaccgtg cgggccgcgc acgccaagct gttcgctccg ctggacccga
    13441 tgtcgactgg acggttgcgg agcttcgtct acggacagcc gctggactga gtcagcgctc
    13501 gagaacgaag accgggatca gccgctcggt cttcttctcg tactccgcga aaccctccgc
    13561 gtgctcgacc atcttggcgt acagccggtc gcgctcggcg cggtcggtca cgagcttcgc
    13621 cttcgccggg aacttgtcgg tgccgatctc gaccgtgacg gccgggttcg cgacgaggtt
    13681 gtggtaccag tccgggttgg tgtccgcgcc gcccttggac gcgacgatca cgatccggtc
    13741 gccgtcagtg gtgtacacca gcgggctgac ccgctgtttg ccgcttttcg cgccggtgtg
    13801 cgtgatcagc accatgttct tgccctcgaa catgccgccg accttgcccg cgttcgcgcg
    13861 gaactcgtcg atgatctgct ggttccagtc cgacatcgga aaactccctg attgatgatg
    13921 taacaacaaa cctaggatcg cgcgaatcgg gctgtcaaca cacgcgcagg tactgtcgcg
    13981 gcatggccac cgaatccggc ccgaccgtcg aggacggggt ccgcgaactg ctgctgctca
    14041 tgccccgtct cgtcgggcgc gcgaagcgga cgccgccgcc tccggaactc gacgacgtcg
    14101 cgctcgcgcc gcggcatttg tccctgctgg cctacctgtt gttcgacggc ccgatgacgg
    14161 tcaacgaact cgccggacgg ctcgaaatcg cgcccaccac agcgagtctg atgatcggcg
    14221 atctgtcccg gcaaggcgtg ctggagcgcg ccgaggaccc ggacgaccgg cggcgcacca
    14281 tcgtgagcat ccacgcggac aagcggcccg ccgtggacgc gtggctcgcc cgcggggcga
    14341 aggcgtggga ggcggcgctg gcgccgttga gtcctggcga gcgggcagtg gtgatcagga
    14401 cgttgcgggc gtatgaggag tacgggtcgt gagtggcaac gccggttcta accggtattg
    14461 ccactcacga ggcgactagc cactgcgcct gcggtcccgc gcatttccgc ggccaagcgg
    14521 cgtcgtgctg ataccaccag gcctcgcagg cccgcccgtc cggcagcgtg tactgcggcg
    14581 ggcccggcac ccggcgcagt ccggccgctt ccagcgaacg gccgctcgcg acgttgccga
    14641 cctccgcgcc cgcgcgcacc cgcgaaagcc cgagatgctc atgcgccagc accaggcccg
    14701 cggcgaacag gtcgcggccg aatccttgcc cgcgataccc cggcgcgaga tagccgccgg
    14761 tttccgggcc gccgtcctcg ccggcgtgca cgctcacgag accggcgcag cggcccgcca
    14821 cgagatcgat cgcgacgacg tccaccgaat gcgggtccgg cgtggtccag tccggtccgg
    14881 tgccggggat gacgcgcagc gcctcgccgc gcatcggctc ggccaccacc gaatcgggaa
    14941 gccagccgag ccagcgctgc gcggccggat cgctgccgcc cgcgaccgcc gccgcgtact
    15001 cccaggcggt gggggtgcgg aaaaggaacc ggccgaacgc gaaggcatgt ccccggcggt
    15061 cgcaggtgcg ttttgccatc agccgtccgc ggcgggtcag ccggctcacc aaaggtgcat
    15121 tgctcacaaa cgccatcgcg ccgggaatgc tacccctcgc cagttgccaa tccgaccgga
    15181 aggcaggcgg agacggtccg cagccgatgt gctcgccgga aacccgtctc cgcctctggc
    15241 ggtagtcgga ttggccgcga accgcgctgt atggtgatcg ggtgacggcc gtaccggaag
    15301 cagccgacgc cgacggcggg cgcgcgaccc agccaaggca cctcattgtg tcggtctacg
    15361 gcgtgcatca ccaggcgggc ggcgaatggc tttcggtcgc ctcgctgatc gatttgctgg
    15421 ccgcggtcgg ggtcgacgaa cccgccgtgc ggtcgtcgat ttcccggctc aaacggcgcg
    15481 gcgtgctcga agcggtgcgc cgcgacggag ccgccgggta cgaattgtcc ggtaccgcac
    15541 tggatttgct gcgcgaaggc gacgagcgga tcttccgccg ggaccgcgcg aagctcgccg
    15601 acggctggct gctcgcggtg ttttcggtgc cggaagccga acggcacaag cggcacgtgc
    15661 tgcggacaca gttgtcgagg ctcgggttcg gcaccgcgtc ctcaggcgtc tggatcgcgc
    15721 cggcgcacct gtacgaggtc accgtcggca cgctggagcg gctcggactc gccgagtacg
    15781 ccgacctgtt ccgcgccgag cacctcgcct tcggcgaccc gcgcgagaag gtgcgcgaat
    15841 ggtgggacct ggaccagctg aacgagctgt acacggcgtt cctcgaagaa cacgaaccgg
    15901 cgctgcgccg gtggcagcgc cgtcgcacga cgcccgccga cgaagcattc gccgactacc
    15961 tgcgcgtgct caccggctgg cggcggatgc cgtatctcga cccgtgcttg cccgcggaat
    16021 tgctgcccga gggctggtcc ggcatccgcg ccgccgaggt gttcttcacg ctgcacgacc
    16081 ggctcgagga agccgcccgc acgcacctgc ggcaggtgct cagcggttga ccaccgcgta
    16141 gccctgcact tccaccagcg cctcgacgtc ccacagccgg ttgacgccga tgcccgccat
    16201 cgccgggtaa tccgcgccga ccagccgctt ccacacgcgg ccgatttcgc gcgcgtgtgc
    16261 ctggtagtcg tccatgtcga cgatgtagac ggtcaggccg cacaggtccg cgggttcgcc
    16321 gccggccgcg cgcaacgcgg tgagcaggtt gccgagcgcg cgctcgaact gctccacgac
    16381 gccgtcgccg acgatccggt tgtccgcgtc caatgcggtc tgtccggcga ggaacaccag
    16441 cctgccctgc gccgccaccg cgtgcgagaa ccccgacggc ttgcccagtt cggggggatt
    16501 gatccgctcc atgccggtga gcgtaaccca tctatcgtct tcttgacgac cgtaggacag
    16561 acgacatacc ctggttcgcg tgcggatttc agtagtcggc ggcgggccag cgggcctcta
    16621 cttcgccgtg ctcgcgaaac aactcggccc ggaccacgag atcacggtct gggagcgcaa
    16681 cgcgcctgac gacacgttcg gcttcggcgt cgtcttctcg gacgagacgc tcggcggcat
    16741 cgagcacgcc gactcggctg tgcacgaggc gatgagccag gagttcgcgc gctgggacga
    16801 catcgacgtg cactaccgcg gcaccgtgtc gacctcgggc gggcacggct tcgccgcgat
    16861 gagccgcaaa cggctgctcg cgatcctgca gcagcggtgt cgcgaaatgg gcattgatgt
    16921 ccgattccgc agtgtcgcgc cggatcccgc cgaactggcc gcttcctcgg acctcgtggt
    16981 cgcggcggac ggggtgaatt ccgcggtgcg cacggcgttc gccgattcgt tccggccgag
    17041 cgtcgagacc cggcagtgcc gctacctctg gctcggcacc gacctcgtgt tcgacgcgtt
    17101 caagttctac gtgctcgaaa ccccgcatgg catcatgcag gtccacggct atccgtacgg
    17161 ccgggacggc agcacgttca tcctcgagat gcacgatgac gtgtggcagc aggcgttcgg
    17221 tccgatcgcc gcgaccggac tcggcccggg tgaaagcgac gagaagtcga tcgagctgat
    17281 ccgcgagctg tgcggcgaca ttttcgacgg acatcagttg ctggccaaca actccaagtg
    17341 ggccaccttc ggcacggtcc gctgcgaaag ctgggtccac gacaatgtcg tgctgcttgg
    17401 cgacgcggca cacaccgcgc atttctcgat cggatcgggc acgaagctcg ccatggagga
    17461 cgcgctcgcg ctcgccgcgt gtctgcacga gcagccgagt gttccggaag cccttgccgc
    17521 gtatgaagaa gagcgacgtc cagtggtcgc ttctacgcag cgtgcggcgc aggcgagcct
    17581 ggagtggttc gagaatctgg cgcagtacac gcatcaggaa ccggaacagt tcgcgttcaa
    17641 cctgcttacc cgcagccgtc gcgtcaccta cgacaacctg aagctgcggg acaaggaatt
    17701 cgccgcctcg ctggaccagt ggttcgccga ttcgctcggc acttccgtcg cgccgccgat
    17761 gttccagccg gtgcggatcg gttcactcga attgccgaac cggatcatcg tgtcgccgat
    17821 ggacatgtac tccgcggtcg acggcgttcc cggcgaattc cacctggtgc acttgggaag
    17881 caaggcactc ggcggggccg ggatggtgat gaccgagatg atctgcgtgt ccgccgaagg
    17941 ccggatcaca ccgggctgcc ccggcctgta cacctccggg caggaagccg cgtggcagcg
    18001 gatcgtcgag ttcgtgcacc gcgaaacccc ggcgaagatc gggttgcagc tagggcattc
    18061 cggccgcaag ggctccacga aactgatgtg ggaaggcatc gacgacccgc tgccggaagg
    18121 caactgggag gtctgcgcgc cgtccgcgct gccgtactcg ccgaacaacc agacgccgcg
    18181 tgagctgtcc gtcgccgaac tgggcgagat ccgggaccag ttcgtctcgg ccgcggaagc
    18241 tgccgcacgc gccgggttcg atctgctcga actgcactgc gcacacggct atctgttgtc
    18301 gtcgttcctg tccccgctca ccaaccaccg caccgattcc tacggcggct ccccggaaaa
    18361 ccggctgcgc ttcccgctgg aagtcttcga cgcggtccgc gcggtgtggc cggccgaccg
    18421 tccgctcacc gtccggatct ccgccaccga ctggttcgaa ggcggcaacg acgccgacga
    18481 agccgtcgcc atcgcgcaag cgttcgccga acacggcgcg gccgcgatcg acgtgtcgac
    18541 cggtcaggtg gtcagcgagg agaagccgaa gttcggccgc agctaccaaa cgccgtacgc
    18601 cgaccggatc cgcaatgaag tcggccgccg ctatggcacc gcggtgatcg ccgtcggcgc
    18661 gatttcctct tacgacgacg tcaactcgct catcctggcg ggccgggccg acctgtgcgc
    18721 actcggccgc acccacctgt tcaatccaca atggaccctg cacgcggccg ccgcgcagga
    18781 gtatccggtg gcgtggccga aacagtgggc agcgggcaaa cgcccgccgc aaaccggccg
    18841 caccgacggt ccagaaccgc ggctcgacct ggtccgcacc ggcggccacc agaccgccca
    18901 tgcccgctgg cgaccggagg acgcccgatg aacgctttcg ctttcactcc ggaacagacc
    18961 gcgtactccg cttccgtccg gaaaatcgcc gccgaacagc tagtcgacct ggccgctgcc
    19021 ggcgccgaag gcgcggtcaa ccgtccactg ctcaaggcca tgggcgccca cggtttgctc
    19081 gctcggctgt tccccggggt cgaaagcgga cagccgaccc ggcaagccgc cgcgaccgac
    19141 ctgtgcttgc tgcgcgaagc tctcgccacg caaagcaccg aagccgagac cgccttggca
    19201 ttgcagggct tgggcagcta cccggtactt cagtccggtt tggacgagca ggtccaacgc
    19261 tggctccccg ccgtagccgc cggtgacgcc gtcgccgctt tcgcactgac cgaaccggac
    19321 gcgggatccg acgccgccgc gctgcaactc gccgccgaac cagacggcga cggctggcgg
    19381 ctcaccggca cgaaaatgtg gatctcgaac gccccggaag ccgacttcta cacggtcttc
    19441 gcccgcacga ctcccgacgc cggagcacgc ggcgtcagcg ccttcgtcgt ccccggcgat
    19501 cgcgccggac tcagcggcga acacctggat ttggtgagcc cgcacccgat cggcacggtg
    19561 gtattcgacg gcgtccgggt gaatctcgac gaactgctcg gcgaggagaa tcgcggtttc
    19621 gccgtagcca tgcggacttt ggacctgttc cgtccgagcg tcggcgcttt cgcggtcggc
    19681 atggcacaag ccgccctcga cgcgaccgtg gagtacacag cttcgcgcga ggccttcggc
    19741 ggcccgttgg tgaagcagca aactgtggca cacacgctgg ccgaaatggc cacgcgaacg
    19801 gaagccggcc gcctcctggt ctacgccgca gcagccgctt acgacgcggg cgagcagaat
    19861 ctggccggtc gcgcggcgat ggcgaagttg ttcgcgaccg agaccgcgca atatgtggtg
    19921 gatcaagcgg tgcaattgca cggcgcacga gcactgcggc gcgggcattt gctggagcat
    19981 ctctaccggg aggtccgggc gccgcgcatt tacgaaggcg cgtccgagat ccagcggacg
    20041 atcatcgcgc ggtcgttgca gcggcgcgga tgagccggca ttcggtgtac ccctcgcacc
    20101 gaatgcgtcc gcgccgcctg ctggttttct aacaagcagg cggcgcggac gacaaactat
    20161 tcagccaggg ctaaacactc gcgcggcggt tcggcttccg gtcgagccac agctgcgccg
    20221 cgatcagcgc gaccgtccag ctcacccacg ccccgagcgc cgcgatcgac tgccccagcg
    20281 cgatttcgct gccgccgaac gtggtggcga gctgcggttc caggaagatc gccgcgatcg
    20341 ggccgatcag ccggttgagg atgatcgaca tcgtcagcgc gaaactgcgg accatccagc
    20401 gccggtgatc gccgaaccgg cgttcgcgag cggcacgata gcccgcccac gtcgtaccga
    20461 gccacaccac ggcgagcagc acgtcactgg cccgggtcac cggcccgaac ggagtcgccg
    20521 cgccgatcgt caacgccagc agcccggagg gcagcacgcc ggcgaacacg tacgcgcggc
    20581 cggagcagcg gtgcagcacc gggtacttcc gccggatcca cggccagatc tgcagcgccg
    20641 cggtcaccat cgcgaccgat ccgaacacca cgtgccccac caggaacaag tagtgcgcgg
    20701 ggaacgtcga cggcacccgt gaccgcgccg gatcgaatgc cagatacggc ggcagcgaat
    20761 acgccaggaa cgcgaccacc accagtccca acggccccac ccacggccgc cgccaccagt
    20821 gcttcttcgg ctcgacccgt ttcgttcggt ccgctgcggg cggcacccgc ggtggtcgaa
    20881 gatccgtccc cgccgtcatc tcggcctctc tccgtcgtcc gttctcggct ggcacttccg
    20941 aacgtaggac ggcggctgcc ggcgaaccat ggtgccgact ggcgtcaccg cggtggggac
    21001 agccttaccc tcggccaggt gacccgctga accgagcgtg acca
//
