LOCUS       NZ_CP091381            22517 bp    DNA     circular CON 18-AUG-2024
DEFINITION  Amycolatopsis sp. FU40 chromosome, complete genome.
ACCESSION   NZ_CP091381
VERSION     NZ_CP091381.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. FU40
  ORGANISM  Amycolatopsis sp. FU40
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 9944196)
  AUTHORS   Reisman,B.J. and Bachmann,B.O.
  TITLE     Biosynthesis of Apoptolidin Family Glycomacrolides
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9944196)
  AUTHORS   Reisman,B.J. and Bachmann,B.O.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-2022) Chemistry, Vanderbilt University, 1234
            Stevenson Center Drive; Room 7330, Nashville, TN 37235, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 23-JAN-2022
            Assembly Method                   :: Flye v. 2.9
            Assembly Name                     :: NFU40_flye_2.9
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 47.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_021903635.1-RS_2024_08_18
            Annotation Date                   :: 08/18/2024 04:30:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,491
            CDSs (total)                      :: 9,417
            Genes (coding)                    :: 9,360
            CDSs (with protein)               :: 9,360
            Genes (RNA)                       :: 74
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 7 of 57
            Pseudo Genes (incomplete)         :: 50 of 57
            Pseudo Genes (internal stop)      :: 5 of 57
            Pseudo Genes (multiple problems)  :: 5 of 57
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:13:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6448220
            Orig. end                         :: 6470737
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP091381.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Brian O. Bachmann,
            Vanderbilt University.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22517
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="31"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22517
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22517
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12517](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12517
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            complement(226..1143)
                     /locus_tag="L3Q65_RS30105"
                     /old_locus_tag="L3Q65_30105"
     CDS             complement(226..1143)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012955.4"
                     /locus_tag="L3Q65_RS30105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_30105"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_237597249.1"
                     /transl_table=11
                     /translation="MAHWFDLGDVAVVPLIEDDRLLIEPGEFFPGLEPDLAGWDAQEPW
                     FDRAAGKLVFAIQSFLVCSTDEVLVVDACVGAGKDRRRAEFDQLPDRWMRQFLATGLRP
                     AEVDAVVFTHLHTDHVGAATVQREPVFPDAPHFMVEEEFRYWSSEAGGAAMRRTGDYLT
                     DSVLPIEQAGQLSFVAPDAVLGKHAELVPAAGHTPGNVCVRVRGSAGTVLLAGDTMHHG
                     VQIRHPELSTRYCVDPEEAARVRSRILEEAGDSVLLPTHFPAPSAGRVRRGRGGYGFVF
                     ASDLLRAGPFRYGEWREQRWGREC"
     gene            complement(1118..2344)
                     /locus_tag="L3Q65_RS30110"
                     /old_locus_tag="L3Q65_30110"
     CDS             complement(1118..2344)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="L3Q65_RS30110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_30110"
                     /product="MFS transporter"
                     /protein_id="WP_237597250.1"
                     /transl_table=11
                     /translation="MSKSIHWPVVLLCFLAVLLDGFDTAALSFTIPTLSREWGSVPAAF
                     TLPLVLTNIGVVLGYLAAGYVGARMKARSVVLTGVLIFAGATVLTAAILHLKSMPVFAA
                     ARLITGLGLGLVLPAGVSLATKHSAESRRELVSVAVTLGLASGSSLGGFFGGKLLHSVG
                     SAGVFYVAGLAPLVLAAVMAVVLPAREPAVESTAKQEAKVSRLFGPGLRLPTSLIWAFS
                     FLIFITAYVLISWVPTLLTGYGFAAGTAPLGLAFLTLGGIAGGLVLIPLAARIGIARAL
                     ILMPAIGAGCMVLVATVPVGETLLFVLLAGAGFGVTAGQIGQLTLAVSIYPAHTRTTGV
                     GWAAALGRIGSIVGPGVAGLLLALALSAQTIVLAAAVPVLVAIACAVGLSRVRPKARKE
                     HDGALVRSR"
     gene            complement(2341..3594)
                     /locus_tag="L3Q65_RS30115"
                     /old_locus_tag="L3Q65_30115"
     CDS             complement(2341..3594)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005168269.1"
                     /locus_tag="L3Q65_RS30115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_30115"
                     /product="carboxylesterase family protein"
                     /protein_id="WP_237597251.1"
                     /transl_table=11
                     /translation="MTESQPVTARPPSGPVLGASSDDGLLRFRGVRYGTAERFQLPRPA
                     EPRSDAVLPGPICPQLGSRLEAAMGPPRDEPPQSEDCLNLAVVTPALTGARPVLVWLHG
                     GGFLSGGGTLPWYDGGRLAADGDVVVVSVNYRLGALGYLVHDGVSEGNLGLADQALALE
                     WVRDNIAAFGGDPGNVTVFGQSAGALSTLALLSEPDSRSLIRRAIVQSSPDPAIIQDRR
                     KAREIGRYFVDAVGGDPVTASVDQLLAAQQRTLRWNAAKDPTSTRPPFGIVDLEVQLSD
                     PLPDLMIGYTTQECEAFAIGVHDDGIRQAIAVQTEPLFARPARDLAQQYGAYSYEFDWT
                     PDHGGYGAIHCLELPFLLGTPESWRGSPMLGDTSWADVERLGTQMRLWWTEFARSGKPG
                     PQSGFRIGNSPQRLENTP"
     gene            complement(3709..3876)
                     /locus_tag="L3Q65_RS30120"
                     /old_locus_tag="L3Q65_30120"
     CDS             complement(3709..3876)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="L3Q65_RS30120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="L3Q65_30120"
                     /product="hypothetical protein"
                     /protein_id="WP_182889845.1"
                     /transl_table=11
                     /translation="MGPLLVLMLCPIWLPLLGMLIGKLADIFSGGGKRAEPAHRMVRAE
                     PAEAGSRVSR"
     gene            complement(3914..4456)
                     /locus_tag="L3Q65_RS30125"
                     /old_locus_tag="L3Q65_30125"
     CDS             complement(3914..4456)
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:TIGR02937.1"
                     /locus_tag="L3Q65_RS30125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_30125"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_182889844.1"
                     /transl_table=11
                     /translation="METELLGRARSGDQAAFAVIYQEHAPPVFRYLRMRVPTATVAEDL
                     TSEAFLRAWRKLPDFRPDVGSFTGWLYTIADNLLRDHRKSARYRRELLDGKDHDGPDVR
                     GGADRLALARIEAAALRRCLADLSEPQRECVRLRFFAGLSVAEVAETMNKNPNSIRALQ
                     HRAVRTLATLLAETEKA"
     gene            complement(4463..4654)
                     /locus_tag="L3Q65_RS30130"
                     /old_locus_tag="L3Q65_30130"
     CDS             complement(4463..4654)
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1265: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009083317.1"
                     /locus_tag="L3Q65_RS30130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_30130"
                     /product="ferredoxin"
                     /protein_id="WP_182890235.1"
                     /transl_table=11
                     /translation="MKIVADRGKCEGLGMCEAMADQFFEVGEDGVVQVLDETPPEADRQ
                     FVDAAVQACPVAALRLQD"
     gene            complement(4651..6060)
                     /locus_tag="L3Q65_RS30135"
                     /old_locus_tag="L3Q65_30135"
     CDS             complement(4651..6060)
                     /EC_number="1.14.19.-"
                     /GO_process="GO:0006629 - lipid metabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009083321.1"
                     /locus_tag="L3Q65_RS30135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_30135"
                     /product="fatty acid desaturase"
                     /protein_id="WP_182889843.1"
                     /transl_table=11
                     /translation="MKKYRLAGANGETAWHDRKRHLWLLGLVVPLLPFGAIGLHAATGS
                     DAVLWLGPLVVLVLVPLIDLVAGYDHTNPPDEVMEALEEDRYYRWITYLFLPLQYAGFV
                     AGAWMLARGELSVGGKIGLAITLGTVAGIAINTAHELGHKRESTERWAAKIALAQCFYG
                     HFYIEHNRGHHVRVATPEDPASSRMGESFYRFWPRTVFGSLRSAWGVERKRYARKQSHP
                     FRLGNDVLNAWLMSVVLWGALIAWLGVGILPYLVIQAVFGFSLLEIVNYMEHYGMLRKQ
                     VVNGAKTRYERVTPAHSWNSNNVATNVLLYHLQRHSDHHANPTRRFQTLRDFKESPVLP
                     TGYTGMMVVALVPAWFRKVMDPRVYRHFDGDIRQANVQPGKLPSLLKKYPVVAAAADEP
                     AADTRAKLADDVDAARCPGCGYIYRVAEGNELEGFAAGTAWSEIPDDWTCPDCGVRDKV
                     DFVPVVREAAC"
     gene            6188..7429
                     /locus_tag="L3Q65_RS30140"
                     /old_locus_tag="L3Q65_30140"
     CDS             6188..7429
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020664813.1"
                     /locus_tag="L3Q65_RS30140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_30140"
                     /product="CdaR family transcriptional regulator"
                     /protein_id="WP_237597252.1"
                     /transl_table=11
                     /translation="MTSTAAATLAKVADSVLAELALLCARIVEEIAEAVPVLAPDAQAG
                     ELLESSVRENLVAALGVLSGATRPADVGAPPAALEFARRLAQRRVPITAMLRAYRLGQA
                     SFQQEMIARIAAEPVATAEISAAATDLSQVAFTYIDKISEEVVEAYQAERDTWLRHRNA
                     ARLAKVQAALSGKPVDIADVEKTLGYALSDRHVGAVLWCGPELDESARLTTLERHAALL
                     ANVLGATPLVVAPDASTVWAWFPTSTLDLDAVSAALASSPDPVRVALGDPASGLAGFRT
                     THQQARQAEAVAQMTERTQPRPVTAAAQLGPLALVAADPSAVAGWVQAVLGALADDDEG
                     HRRMRETVWAYLSSGSSLMVAAQELHLHKNTIQYRLRKAEQERGRPLSEGRIDVEVALL
                     ACRLLGPAVLRPVG"
     gene            7547..9241
                     /locus_tag="L3Q65_RS30145"
                     /old_locus_tag="L3Q65_30145"
     CDS             7547..9241
                     /GO_function="GO:0016614 - oxidoreductase activity, acting
                     on CH-OH group of donors [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009083323.1"
                     /locus_tag="L3Q65_RS30145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_30145"
                     /product="GMC oxidoreductase"
                     /protein_id="WP_237597253.1"
                     /transl_table=11
                     /translation="MNDTREETDVLVIGSGFGGSVSALRLSEKDYRVTVLEAGPRRTEE
                     TLPRTSWDVRNFLWAPRLGCYGIQRIHLLRDVVILGGAGVGGGSLNYANTLYEPPAPFF
                     EDPQWAHVTDWQAELKPHYDQARRMLGVTQNPTVTAADQVLREVADDLGVGSSFRLTPV
                     GVFFGDKETPAGTVVPDPFFGGAGPARRTCTECGSCMTGCRVGAKNTLDRNYLYLAEQR
                     GANVVPMTTVLDVRPADGGYLVTAVRTGKSPRRRKNVRTFFARDVIFSAGTYNTQKLLH
                     QARETGALPRISASLGRLTRTNSESILGAKSKRKDVDFTHGVAITSSVHPDAHTHIEPC
                     RYGKGSNAMSLLQTALTDGGKPVPRWLTWLGAFARNPRNFTWFSPRRWSERTIILLVMQ
                     TLDNSITVSGKRTRTGRHTLTSAPGHGEPNPTWIPAGNDAARRVAEKIDGIAGGTTGEI
                     LNIPMTAHFIGGCAISDDPANGVLDPYQRIHGHPGLHVVDGSAISANLGVNPSLTITAQ
                     AERAMSFWPNRGEEDRRPPLGAPYARIAPAAPRHPAVPADAPGALIP"
     gene            9533..9658
                     /locus_tag="L3Q65_RS47405"
     CDS             9533..9658
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="L3Q65_RS47405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_255751035.1"
                     /transl_table=11
                     /translation="MKTLPERYQAPEASSVGCFATDTRRLRRGARDHRRHGRRRR"
     gene            9785..9910
                     /locus_tag="L3Q65_RS47410"
     CDS             9785..9910
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="L3Q65_RS47410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_255751036.1"
                     /transl_table=11
                     /translation="MKTLPERYQAPKARPAGRFATVTRSFGRGNRDAILHGLRRR"
     gene            10001..11839
                     /locus_tag="L3Q65_RS30150"
                     /old_locus_tag="L3Q65_30150"
     CDS             10001..11839
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.4"
                     /locus_tag="L3Q65_RS30150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_30150"
                     /product="asparagine synthase"
                     /protein_id="WP_182889840.1"
                     /sec_met_domain="Asn_synthase (E-value: 1.7e-35, bitscore:
                     122.4, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNALSSSLVVLPDSPAGTALLPRVPYRRPSVLFHSSGRPWLAGRW
                     EPGEIRVAITGRARVAVFGFCPMPVERLTAYTARLRTVSDADALARVLPGSAHLIASVN
                     GQTRLQGTLANLRRAFHTQIGSVPIAGTRADVLAEMTGADLDENLLAAHLTEMQLLPPL
                     IEKSWWRTVHSVPPDSAVVLTDDGPASTVRWWRPPEPDLPIRKGAPAVRSALRESVAER
                     RPAQGRLSLDLSGGMDSTTLCFLAAAQTPDLFTFRWSGGSVANDDPIFAAEAARLLPGV
                     EHLERSDASAPALFAPPYATGDLEAPWTMTRGLNGSAHGVRVLAEHGSGLHLAGHGGDE
                     VFSGSAGYLHTLVRRRPLTGLRQLRVYRSLGRWSWPQTLAALADRQSWGDWWRDSADQL
                     TDPLPRPGTPDLGWADPVRAAPWATGDALATTRRVLYEIAAEAVPLAADRGQHQALTSL
                     RAAGPLCQQIQREYAAEGVPLDLPYLDDRVVEAALAVRTSDRFTPWRYKPLLADAMRGL
                     VPDVILDRTTKGNYQDDDDAEAHRHVPDLLDYFADSALAARGLLDLDAFRACLLEPRLD
                     DEVEAHLETALGCEMWLRAIADARPATDRRTHAPAP"
     gene            11823..12077
                     /locus_tag="L3Q65_RS30155"
                     /old_locus_tag="L3Q65_30155"
     CDS             11823..12077
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015102766.1"
                     /locus_tag="L3Q65_RS30155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_30155"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_182889839.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 2.8e-25,
                     bitscore: 87.2, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 4.7e-13, bitscore: 48.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHLHPDTALTDTPDGSVLLNKRTGRYWQVNRTGTHTLDRLLAGET
                     ADQIAADLAARYDIDAAQVQADITAMTESLLAAGLVEPS"
     aSDomain        11826..12068
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_L3Q65_RS30155_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="8.50E-28"
                     /identifier="RREFam002.1"
                     /label="L3Q65_RS30155"
                     /locus_tag="L3Q65_RS30155"
                     /protein_end="82"
                     /protein_start="1"
                     /score="87.2"
                     /tool="antismash"
                     /translation="HLHPDTALTDTPDGSVLLNKRTGRYWQVNRTGTHTLDRLLAGETA
                     DQIAADLAARYDIDAAQVQADITAMTESLLAAGLVE"
     gene            12074..12517
                     /locus_tag="L3Q65_RS30160"
                     /old_locus_tag="L3Q65_30160"
     CDS             12074..12517
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015102767.1"
                     /locus_tag="L3Q65_RS30160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_30160"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_182889838.1"
                     /sec_met_domain="PF13471 (E-value: 9.7e-24, bitscore: 82.7,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQPTVVPHRIRLPLHRKLLPLLIVGLATVLTALSPKHLCAILRF
                     ARRGARPATFEQARFARRSVVAISLRCAGDGCLLRSVAAALLCRVHGTWPTWRTGVRTQ
                     PFSAHAWIEADGQVVDEIHPAGYFAPLLTVAPLRTARNDRHRP"
     gene            12498..14204
                     /locus_tag="L3Q65_RS30165"
                     /old_locus_tag="L3Q65_30165"
     CDS             12498..14204
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="L3Q65_RS30165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_30165"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_182889837.1"
                     /transl_table=11
                     /translation="MTVTAPETSTSATEQPARSRVGLRHLFAATRGHRRNIAVALLFTL
                     VGAGLGLLQPMLAMQTIDAVGAGGAVGWLLVALVTVFVAEAGADTIGRYWLERSGEGVV
                     LGLRVRLISHLLRLPMRLYDHHRIGDLLSRTTADTTLLRDTLAYDLVEMLTGSFVVIGG
                     TVAMLWLSPLLFGIVAVIVGGVGGVTLFVLARIRNATENAQDNLGLMAAELERALSAIR
                     TIRATRAEDRETARIGHYAHTTYQDNVRAARLNSIAGPAVTLSAHGALIAVLVTGGIQV
                     ANGNLTLAELVAFLLYVSYIAVPSAGLFELAATIQRGLAAFQRVHDMTRLPTETDHTPT
                     SLVSPASAPVLELRDVWFSYHPDRPVLRGVSFTVPRRGHVALVGPSGAGKSTILALIER
                     FYEPDRGTILFNGYQPSIAECRQRIGLVEQTTPILHGTLRDNLTYAAPDATDEQIRDVL
                     EKTNLTEFVSRLPAGLETPAGEHGGMLSGGQRQRLAIARALLARPELLLLDEPTSQLDA
                     ANEAAFAQTLDQVAGECALLVIAHRPATVRRAQTVIALEQGRISTDAGLVP"
     misc_feature    12720..12722
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(14201..14692)
                     /locus_tag="L3Q65_RS30170"
                     /old_locus_tag="L3Q65_30170"
     CDS             complement(14201..14692)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="L3Q65_RS30170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="L3Q65_30170"
                     /product="hypothetical protein"
                     /protein_id="WP_182889836.1"
                     /transl_table=11
                     /translation="MRISARQVVSRVLLAAALFSGVGCLITGLGQQGDVDDAYRIEFGH
                     EGDACDEKRHLHLSVDTGEAMDCTAYPQFSFGGSTTLPGFTPAQNGEIGDLVKGLAVGG
                     LSEAEQRQIQDRVDEIAVTVPESERPYHYTGLWGTGLAWLGGAILAVSLLLFAGRRVRR
                     "
     gene            14751..15017
                     /locus_tag="L3Q65_RS30175"
                     /old_locus_tag="L3Q65_30175"
     CDS             14751..15017
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="L3Q65_RS30175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="L3Q65_30175"
                     /product="hypothetical protein"
                     /protein_id="WP_182889835.1"
                     /transl_table=11
                     /translation="MTDGEQPDLDEIEEHFVALLDGRITRDAVDRWAGRWLADDSLSWD
                     ELNWWALGLLHGIDLRHGPGGAYLHDDSQVQDWLAEFRSRRTR"
     gene            15092..15640
                     /locus_tag="L3Q65_RS30180"
                     /old_locus_tag="L3Q65_30180"
     CDS             15092..15640
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF028018.4"
                     /locus_tag="L3Q65_RS30180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_30180"
                     /product="LppA family lipoprotein"
                     /protein_id="WP_255751037.1"
                     /transl_table=11
                     /translation="MPLPSRSAARLATLALALALTSGCSQNPPYVPEGYAKMMKLPDID
                     QAKATYTAMVTAIRDRLTAEFGRTWEKGSEVNSYTCGIGYIGVGSDSLKLHLPMWKSSG
                     SLAEADWPRAQALVGQLAAGYGFRPAPEANQPGNHTMGYTDPNGAMLHFGTGNFTVIEV
                     TTGCHLTAEAHRRGGPTHD"
     gene            16107..16565
                     /locus_tag="L3Q65_RS30185"
                     /old_locus_tag="L3Q65_30185"
     CDS             16107..16565
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012783362.1"
                     /locus_tag="L3Q65_RS30185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_30185"
                     /product="prevent-host-death protein"
                     /protein_id="WP_182889833.1"
                     /transl_table=11
                     /translation="MIPAADLSGATRRSSDLSKHSAEVFAEAEDHPVTVTRRDGEALVL
                     MSKREAEGRSRLLDFAAQLITVTLDDQGTLADRMAKVFPWMLALSPADRASCAQDLVDA
                     ARASFSTDQPHLAIAELTSWKETATAVAAGLGRTDLEWLDEDETVERP"
     gene            16568..16918
                     /locus_tag="L3Q65_RS30190"
                     /old_locus_tag="L3Q65_30190"
     CDS             16568..16918
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003944211.1"
                     /locus_tag="L3Q65_RS30190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_30190"
                     /product="hypothetical protein"
                     /protein_id="WP_237597254.1"
                     /transl_table=11
                     /translation="MASAKKGELVPRPPKKIEYEIRFATTDALKGWRDLVATIRNAMAD
                     TWDFLTRTPQATTPTNYRLKGELKTVQRGGKSYARWQHKPTAGGSARIWFYVSERTVYL
                     EQVHTHHPNETK"
     tRNA            complement(17490..17563)
                     /anticodon=(pos:complement(6465747..6465749),aa:Leu,
                     seq:taa)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="L3Q65_RS30195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="L3Q65_30195"
                     /product="tRNA-Leu"
     gene            complement(17490..17563)
                     /locus_tag="L3Q65_RS30195"
                     /old_locus_tag="L3Q65_30195"
     gene            complement(17644..18972)
                     /locus_tag="L3Q65_RS30200"
                     /old_locus_tag="L3Q65_30200"
     CDS             complement(17644..18972)
                     /EC_number="1.6.5.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020664793.1"
                     /locus_tag="L3Q65_RS30200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_30200"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_182889831.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.9e-45, bitscore:
                     153.8, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAAKSEPTRILVLGGGYVGLYTAYGLQKMLRANEASVTVVDPQP
                     HMTYAPFLPEAAAGAIEPRHVVVPLRRVLKRCHVLTARVTKIENERKAVTVEAADGHIE
                     TLNYDVLVVALGAVARILPIPGLAEEGIAFKTIGEAIYLRNHIMTKLDEAASTLDPELR
                     KRLLTFTVVGGGFAGIEALAELEDMTRFAVENYYPNIKPADIRWVMVEAAGRILPEVRE
                     TLGVYTVQQLEKRGIEVYLSTAAKSFENGHVVLSDGTEFDTDTIIWTAGVKANPVLAGS
                     DLPLDKRGRVEATAAMQVVGHPDVWTAGDNAAIPDLSRTEQDPTATCPPNAQHAVRQAR
                     LLAKNIIKVIRGGQPKDYYHKNLGAVASLGLHKGVADALNLKIKGFPAWLFHRAYHLKA
                     MPTWNRKIRILFDWMLGGLFRREVISLGQINNPKEEFNRASKG"
     gene            complement(19057..19740)
                     /locus_tag="L3Q65_RS30205"
                     /old_locus_tag="L3Q65_30205"
     CDS             complement(19057..19740)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009083328.1"
                     /locus_tag="L3Q65_RS30205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_30205"
                     /product="uracil-DNA glycosylase"
                     /protein_id="WP_182889830.1"
                     /transl_table=11
                     /translation="MRTFADLDASLVECRACPRLVEWREGVAGTKAAFAGERYWSRPVP
                     GFGAEDAALAVVGLAPSAHGANRTGRMFTGDPSGDFLFRVLYEVGLASQPVSAAIGDGL
                     TLRGTRLVSPVRCAPPENRPTPAERDTCRHWLADELDLLRPTLRSIVVLGAFGWQALLP
                     VLSAAGWPVPKPRPAFAHGARMQVGDLAVFGCYHVSPRNVQTGRVTQPMVVTAFTAAAS
                     AAGLI"
     gene            19779..21269
                     /locus_tag="L3Q65_RS30210"
                     /old_locus_tag="L3Q65_30210"
     CDS             19779..21269
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003063317.1"
                     /locus_tag="L3Q65_RS30210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_30210"
                     /product="S10 family peptidase"
                     /protein_id="WP_182889829.1"
                     /transl_table=11
                     /translation="MADTTADETAEKTKDEETKAAEPVDDLVTTQHTLTVKRRKLAYTA
                     QTGRIVLRQEVKKDGKSEGYQAKAEVFLTAYTLDDADPGTRPVTFAFNGGPGSSSIWLH
                     MGLLGPRRVLSGDVNDPVPPPYGLEDNPESLLAHSDLVFIDPVQTGYSRVTEGGESQPY
                     TGFQGDVESVAEIIRLWVSRNQRWLSPKFLAGESYGTLRAAALAGHLQERYGLYLNGLM
                     LISSVLDLGTLRFHEGNDLPYSLFLPTYAAIAHYHGRHGDRPLDDVLADAEDFASKELP
                     WALSRGARLSTQDRTEAVQTLASLTGLSESYVDRVNLRIEHIRFFTELLRDQGKTVGRM
                     DGRFTTWEPDGGVEHMSDDPSVSRIIGAYSAGFNHYVRADLGYENDLPYEILSSDVFKS
                     WSYKEFEGRSVSVVDTLSAAMRANPHLQVHVAFGHYDGATAYYASEYVLSQLKIPEELR
                     ENIDTAYYPAGHMMYVHEPSRVQQSKDLGKFVKKASNR"
     gene            complement(21310..21912)
                     /locus_tag="L3Q65_RS30215"
                     /old_locus_tag="L3Q65_30215"
     CDS             complement(21310..21912)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020645900.1"
                     /locus_tag="L3Q65_RS30215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_30215"
                     /product="DNA-binding response regulator"
                     /protein_id="WP_037820278.1"
                     /transl_table=11
                     /translation="MTTVVLADDEALLRKAMAALLPMEDEITVLAEAEDGEAAVRATVE
                     HRPDVLVIDLEMPNVDGLGAVARIRRERPEQVILMLTRHARPGVLRKALKLGVQGFVSK
                     SAEPAHIAAVIRTLDEGKRWIDPDVSALAVVDDCPLTVREIDVLRATREGYSVADIATQ
                     LHLAEGTVRNYLSNAMQKTQTRTRHEAARYAREHDWL"
ORIGIN
        1 cgaaaccggc gaaactgccg ctgcacctgg acgtgaaccc gaccgaccgg gaccaggacg
       61 cggagctgga acgcctgctc gcggccggtg cgcggcccgc cgaggtcggg cagaccgggg
      121 aggagtcgtg gcacgtgctc gcggacccgg aggggaacgt gttctgcctg ctccgccgtc
      181 gggtcgaccc ggtgtcgtga gtggcgttgc cggtgagaac cggcctcagc actcacgccc
      241 ccagcgctgc tcccgccact ccccgtaccg aaacggcccg gcccggagca ggtcgctcgc
      301 gaacacgaag ccgtatccgc cccggccacg ccgcacccgg cccgccgagg gcgcggggaa
      361 atgcgtcggc agcaggacgg agtcgcccgc ctcctcgaga atgcggctcc gaaccctcgc
      421 cgcttcctcc ggatcgacgc agtacctcgt gctcagctcc ggatgccgga tctgcactcc
      481 gtggtgcatc gtgtccccag cgagcagcac ggtcccagcg ctgccgcgga cccgcacgca
      541 cacattcccc ggcgtgtgcc cagccgccgg aacgagttcg gcgtgcttgc ccagcaccgc
      601 gtccggggcc acaaaactca actgcccggc ctgctcgatc ggcaggacgc tgtcggtcaa
      661 gtagtcgcca gtccggcgca tggccgcccc gccggcctcg ctcgaccagt accggaattc
      721 ctcctcgacc atgaagtgcg gcgcgtccgg gaagaccggt tcccgctgca cagtggcggc
      781 cccgacgtga tcggtgtgca agtgggtgaa caccaccgcg tcgacttccg cggggcgcag
      841 cccggtcgcg aggaactgcc gcatccaccg gtccggcagc tgatcgaact ccgcgcgccg
      901 acggtccttg cccgccccga cgcacgcgtc gaccaccagc acttcgtccg tcgagcagac
      961 gaggaacgac tggatggcga agaccagctt ccccgccgcg cggtcgaacc acggctcctg
     1021 ggcgtcccag ccggccaggt ccggttcgag tcccgggaag aactccccgg gctcgatcag
     1081 cagccggtcg tcctcgatga ggggaacgac cgcgacgtca ccgagatcga accagtgcgc
     1141 catcgtgctc ctttctcgcc ttcggccgca cccggctcag ccccaccgcg caagcgattg
     1201 cgaccagcac gggaacggcg gccgccagga cgatcgtctg cgccgacaag gccagcgcga
     1261 gaagcaaacc cgcgacgccc ggcccgacga tcgacccgat ccgccccagc gccgcggccc
     1321 acccgacgcc ggtggtgcgc gtgtgtgcgg gatagatcga gaccgcgagc gtcagctggc
     1381 cgatctgccc ggccgtgact ccgaaaccgg caccggccag cagcacgaac agcagggtct
     1441 cgccgaccgg caccgtcgcg acgaggacca tgcacccggc cccgatggcg ggcatcagga
     1501 tcagcgcgcg ggcgatgccg atccgcgcgg cgagcgggat gagcaccagg ccgcccgcga
     1561 tcccgccgag ggtgaggaac gcgagtccca gcggggccgt cccggcggcg aacccgtaac
     1621 cggtgagcag cgtcggcacc caggagatca gcacgtacgc ggtgatgaag atgaggaacg
     1681 agaacgccca gatgagcgac gtcggcaggc gcagtcccgg gccgaacagc ctgctcacct
     1741 tggcttcctg cttcgccgtg ctctccaccg cgggctcacg cgcgggcagc accacggcca
     1801 tcaccgcagc cagcaccaac ggagccagcc cggcgacgta gaaaaccccg gcggacccga
     1861 cgctgtgcag cagcttcccg ccgaagaacc cgccgagact gctcccggaa gccagcccga
     1921 gggtcaccgc cacggaaacc agctcgcgac ggctctccgc gctgtgcttc gtcgcgagcg
     1981 acaccccggc gggcagcacc agcccgagtc ccagcccggt gatcagccgg gccgcggcga
     2041 agaccggcat ggacttcaga tgcaggatcg cggcggtcag cacggtcgcg cccgcgaaga
     2101 tcaggacgcc ggtgagcacc accgaccgcg ccttcatccg ggcgcccacg taacccgcgg
     2161 ccagatatcc caggacaacc ccgatgttgg tcagcaccag cggcagggtg aaggcggcgg
     2221 ggacggaacc ccattcgcgg gacagcgtcg ggatcgtgaa cgacagcgcg gcggtgtcga
     2281 aaccgtccag gagaacagcg agaaagcaga gcaggacgac gggccaatga atactcttgc
     2341 tcatggcgtg ttctccagtc tctgagggga attcccgatc cggaagccgc tctgcgggcc
     2401 gggcttgcct gaccgcgcga attcggtcca ccacaagcgc atttgggtgc ctaggcgttc
     2461 gacgtcagcc cagctcgtgt cgcccagcat cgggctcccg cgccaggatt ccggggtgcc
     2521 cagcaggaaa ggcagttcga ggcaatggat cgcgccgtag ccgccgtggt ccggagtcca
     2581 gtcgaactcg taggagtacg cgccgtactg ctgtgccaag tcacgcgccg ggcgagcgaa
     2641 aagcggctcg gtctggactg cgatcgcctg ccggatcccg tcgtcgtgca ctccgatcgc
     2701 gaacgcctcg cactcctgcg tggtgtagcc gatcatcaag tccggcaacg gatccgacag
     2761 ctgcacctcg agatcgacga tcccgaacgg cggccgggtc gacgtcggat ccttcgccgc
     2821 gttccaccgg agagtgcgct gttgcgcggc cagcagctga tcgacggaag cggtaacggg
     2881 atctccgccg accgcgtcga cgaaataccg gccgatctcc cgcgctttcc ggcgatcctg
     2941 gatgatcgcg ggatcgggag aactctggac gatcgcccgc cggatgagcg agcgactgtc
     3001 cggttcggac agcaaggcga gcgtcgaaag cgcgccggcg gactggccga agacggtgac
     3061 attgcccggg tccccgccga acgccgcgat gttgtcgcgc acccattcga gcgcgagcgc
     3121 ttggtccgcc agaccgagat tgccctcgct gacgccgtcg tggaccaggt agccgagcgc
     3181 cccgagccgg tagttgaccg acacgaccac cacgtcgccg tccgcggcga gccgtccgcc
     3241 gtcgtaccag ggcagggtgc cgccgccgct caggaaaccg ccgccgtgca gccacaccag
     3301 caccgggcgg gcaccggtca gcgcgggcgt cacgacggcg aggttgaggc agtcctcgga
     3361 ctggggcggt tcatcccgcg gcggccccat cgcggcttcc agccgcgagc cgagctgcgg
     3421 gcagatcggt ccgggcaaca cggcgtcgga acggggctcg gctggccgcg gcagctgaaa
     3481 ccgctcagcg gtcccgtacc gcactccgcg gaaacgcagc aggccgtcgt cgcttgaagc
     3541 gccgagaacc ggaccggacg gcggccgggc agtgacgggc tggctttcgg tcatcgcggc
     3601 tctcctttga gcggggtccg gcaccttcga cccgcagtca ggctaagaaa gtccggaatg
     3661 cctgaccaat gctctttgcc gcccgagaca tgtttgcccg gctatacctc accgcgaaac
     3721 gcggctcccc gcctcggccg gctcggcgcg caccatccga tgcgcgggct cggcccgctt
     3781 gccgccgccg gaaaagatgt ccgcgagctt cccgatcagc atcccgagca gcggaagcca
     3841 gatcgggcac agcatcagca ccagcagtgg ccccatgatc ttgaaaatct cgaggaatcc
     3901 atgcatacca gcgtcacgcc ttttcggtct cggccagcag cgtcgcgagc gtgcgcaccg
     3961 cacggtgctg cagcgcccgg atgctgttgg ggttcttgtt catcgtttcg gcgacctcgg
     4021 cgacggacag tccggcgaaa aaccggagcc gcacgcactc gcgctgcggt tcgctgaggt
     4081 cggccaggca ccggcgcagc gccgccgctt cgatgcgggc cagcgcgagc cggtcggccc
     4141 cgccgcggac gtccggcccg tcgtggtcct tcccgtcgag gagttcacgc cggtagcggg
     4201 ccgatttgcg gtggtcgcgc agcaggttgt cggcgatcgt gtacagccag ccggtgaacg
     4261 agccgacatc cgggcggaag tccggcagct tccgccacgc gcgcaggaac gcctcgctcg
     4321 tcaggtcttc ggcgaccgtc gccgtcggca cccgcatccg caggtagcgg aagaccggcg
     4381 gcgcgtgttc ctggtagatg acggcgaacg cggcctggtc gccagaccgc gcccgcccca
     4441 gcagctccgt ctccacgcgg cctcaatcct gcagccgcaa cgccgcgacc gggcacgcct
     4501 gcaccgccgc gtcgacgaac tgccggtccg cctcgggcgg ggtctcgtcg agaacctgca
     4561 ccacgccgtc ttccccgacc tcgaagaact ggtcggccat cgcctcgcac atgccgaggc
     4621 cctcgcactt tccgcggtcc gcgacgatct tcagcacgcc gcctcccgca ccacgggcac
     4681 gaagtcgacc ttgtcgcgca cgccgcaatc ggggcacgtc cagtcgtccg ggatctccga
     4741 ccacgccgtc ccggcggcga agccctccag ttcgttgccc tcggcgacgc ggtagatgta
     4801 gccgcagcca gggcagcgcg cggcatccac gtcgtcggcc agtttcgctc gggtgtcggc
     4861 ggcgggttcg tccgcggcgg cagcgacgac cgggtacttc ttcagcagcg acgggagttt
     4921 gcccggctgc acgttcgcct gccggatgtc gccgtcgaaa tgccggtaga cccgcgggtc
     4981 catcaccttg cggaaccacg ccgggaccag cgcgacgacc atcatcccgg tgtagccggt
     5041 cggcaggacc gggctttcct tgaagtcgcg caaggtctgg aaccggcgtg tcgggttcgc
     5101 gtggtgatcg ctgtgccgtt gcaggtggta cagcagcaca ttcgtcgcga cgttgttgga
     5161 gttccaggaa tgcgccggag tgacccgctc gtaccgggtc ttggcgccgt tgacgacctg
     5221 cttgcgcagc atcccgtagt gctccatgta attcacgatc tccagcagcg agaacccgaa
     5281 caccgcctga ataaccagat acggcaggat cccgacgccc agccaggcga tcagcgcgcc
     5341 ccacagcacc acgctcatca gccacgcgtt gagcacgtcg ttaccgaggc ggaacgggtg
     5401 gctttgcttg cgggcatagc gtttccgctc gacgccccag gcactgcgca gcgaaccgaa
     5461 gactgtccgc ggccagaacc ggtagaagct ctcgcccatc cggctcgacg ccgggtcctc
     5521 cggagtggcg acgcgaacgt ggtgcccgcg gttgtgctca atgtagaagt gcccgtagaa
     5581 acactgcgcc agcgcgattt tcgccgccca gcgttcggtg ctttcccgtt tgtgaccgag
     5641 ttcgtgcgcg gtgttgatcg cgatgccggc gaccgtgccc aacgtgatcg cgaggccgat
     5701 cttgccgccg acggacagct cgccgcgcgc gagcatccac gcgcccgcca cgaaaccggc
     5761 gtattgcagc ggcaggaaca ggtaggtgat ccagcggtag tagcggtcct cctccagcgc
     5821 ctccatcacc tcgtccggcg gattggtgtg gtcgtatccg gcgacgaggt cgatcagcgg
     5881 cacgaggacc agcacgacga gcggaccgag ccacaggacg gcgtcggacc cggtcgcggc
     5941 gtgcaacccg atcgcgccga acggcagcag cggcaccacg agcccgagca gccacaggtg
     6001 ccgcttccgg tcgtgccatg cggtttcgcc gttcgctccg gcgaggcggt acttcttcat
     6061 ggcggcctcc acgcggtctg tcgttttccc gaaggtagga attcgcgggc ggcgggacac
     6121 tgtgcgcgga accgaaacgc tcggctgcgt tgggtcccgg gcacgaaccg ggcgtacggt
     6181 gctgcctgtg acgtcgacgg ctgccgccac gctggccaag gtcgcggact cggtcctggc
     6241 cgagctcgcg ctgctctgcg cgcggatcgt ggaggagatc gccgaggcgg tcccggtcct
     6301 cgcacccgac gcgcaagccg gggagctgct ggaaagctcg gtccgggaaa acctcgtcgc
     6361 cgcgctgggc gtgctgagcg gcgccacccg gcccgcggac gtcggagccc cgcctgccgc
     6421 gctggagttc gcgcggcggc tggcgcagcg ccgggtgccg atcaccgcga tgctgcgcgc
     6481 gtaccggctc ggccaggcct ccttccagca ggaaatgatc gcccggatcg cggccgaacc
     6541 ggtcgcgacc gcggagatct cggccgccgc caccgacttg tcgcaggtcg cgttcaccta
     6601 catcgacaag atctccgagg aggtggtcga ggcttaccag gcggaacgcg acacctggct
     6661 gcgccaccgc aacgcggccc ggctcgcgaa ggtgcaggcc gcgctgtccg gcaagcccgt
     6721 cgacatcgcc gacgtcgaga aaaccctcgg ctacgcgctg tcggaccggc atgtcggcgc
     6781 ggtgctctgg tgcggtcctg agctggacga aagcgcgcgg ctgaccaccc tcgaacgcca
     6841 cgccgccctg ctcgcgaacg tcctcggggc caccccgctg gtcgtggccc cggacgcctc
     6901 gaccgtgtgg gcctggttcc cgacgtcgac gctcgatctc gacgcggtgt ccgccgccct
     6961 cgccagctca cccgatccgg tgcgcgtcgc gttgggcgac ccggcgagcg gtctcgccgg
     7021 gttccgcacc acccaccagc aggcccgcca ggccgaagcc gtggcgcaga tgaccgagcg
     7081 gacgcaaccg cggccagtca ccgcggcggc gcaactcggg ccgttggcgc tggtcgcggc
     7141 ggatccgtcg gcggtcgcgg gctgggtcca ggcggtgctc ggcgcgctgg ccgacgacga
     7201 cgaggggcac cgtcgcatgc gcgagacggt gtgggcgtac ctgtccagcg ggagcagcct
     7261 gatggtcgcc gcgcaggagc tccacctgca caagaacacc atccagtacc ggctgcgcaa
     7321 ggccgagcag gagcggggcc gtccgctgtc ggaggggcgg atcgacgtcg aggtggcgct
     7381 gctggcgtgc cggctgctcg gtccggcggt gctgcggccg gtcggctgat ttgtgccgcg
     7441 ggaccagtcg ggccccggcc tcccggtccg cggaccgatg ccctcgcctg acctcggcga
     7501 gaagactcgg gcgaacgagt tcgccaccgc gcctgcgagg acaacgatga acgacacccg
     7561 cgaagagacc gacgtcctcg tgatcggctc cggtttcggc ggttccgtga gcgcgctccg
     7621 gctgtccgaa aaggactacc gcgtcaccgt gctggaagcc ggcccccgcc gtaccgaaga
     7681 gacgctgccc agaacctcgt gggacgtccg gaatttcctg tgggcaccgc gcctgggctg
     7741 ctacggaatc cagcgcatcc atctcctccg cgacgtcgtc atcctcggcg gcgcgggcgt
     7801 cggcggcggt tccctcaact acgccaacac cctctacgaa ccgcccgcgc cgtttttcga
     7861 agacccgcag tgggcgcacg tcaccgactg gcaagccgaa ctgaaaccac actacgacca
     7921 ggcccgccgg atgctcggcg tcacccagaa ccccaccgtg accgccgccg atcaggtgct
     7981 ccgcgaagtc gccgacgacc tgggcgtcgg ctcgtcgttc cggctcaccc ctgtcggcgt
     8041 tttcttcggc gacaaggaaa ctccggccgg aaccgtcgtg ccagacccgt tcttcggcgg
     8101 tgccggacca gcccgccgaa cctgcaccga atgcgggtcc tgcatgaccg gctgccgcgt
     8161 cggcgccaaa aacacgctgg accgcaatta cctctacctg gctgaacaac gcggcgcgaa
     8221 cgtcgtcccg atgaccacag tgctcgacgt gcgcccggcg gacggcggct acctcgtcac
     8281 cgcggtccgc accggaaagt cgcctcgccg ccgcaaaaac gtgcgcacct tcttcgcccg
     8341 cgacgtcatc ttcagcgcag gcacctacaa cacgcagaaa ctgctccacc aagcccgcga
     8401 aaccggtgcc ctgccgcgaa tttccgccag cctcggccgg ttgacccgga cgaactcgga
     8461 atccatcctc ggcgcgaaat cgaaacgcaa ggacgtcgac ttcacccacg gcgtcgcgat
     8521 cacctcgtcc gtccacccgg acgcgcacac gcacatcgaa ccgtgccgct acggcaaggg
     8581 cagcaacgcg atgtcgctgc tgcaaaccgc gctcaccgac ggcggaaagc ctgtcccgcg
     8641 ctggctgacc tggctcggcg cgttcgccag gaacccgcgg aacttcacct ggttctcgcc
     8701 gcgccgctgg tccgaacgca ccatcatcct gctggtgatg caaaccctcg acaattcgat
     8761 cacggtctcg ggcaaacgca cccgcaccgg acggcacaca ctgacatccg cacccggcca
     8821 cggcgaaccg aatccgacgt ggatccccgc cggaaacgac gccgcccgcc gcgtcgcgga
     8881 gaaaatcgac ggcatcgcgg gcggcactac cggcgaaatc ctgaacatcc cgatgaccgc
     8941 acatttcatc ggcggctgcg ccatttccga cgacccggcc aacggcgtcc tggacccgta
     9001 ccagcgcatc cacggccacc ccggcctgca cgtcgtcgac ggctcggcga tctccgcgaa
     9061 cctgggcgtc aacccgtccc tgacgatcac cgcgcaagcc gaacgcgcga tgtccttctg
     9121 gcccaaccgc ggcgaggagg accggcgtcc cccgctgggc gcaccgtacg cacgcatcgc
     9181 cccagcagcc ccgcgtcatc ccgcggtccc ggccgatgct cccggcgcgc tcattccctg
     9241 accgcaccac aaaccccggc aacatttccg cagcggaatt aagtacgcac acagaagcat
     9301 ttcggccgcg aaccagaaca gatgcaccgc gccgcatgtc tttcctgcaa aaacaaaacc
     9361 gacacatccg tcggcccaac tgattcgact gaacgcctga gtgtcagccc ctggcagtcc
     9421 tgctagcgtg ttctgcgcgg agcacttcgc acatccggaa agttcatcag cgatcgctat
     9481 cgaacccata agaaatgcca tcagaagtgc gtacagagga ggactggttt ccgtgaagac
     9541 ccttcccgaa cgctatcagg cccctgaggc ctcctcggtc ggctgcttcg cgaccgacac
     9601 ccgccggctg cgccgcggcg cccgcgacca ccgccggcac ggacgtcgtc gccgctgagc
     9661 gaacgatccc ttcgcgggcg gcgagtgcgg cccgctgaac tgatctgacg tggctggagg
     9721 tcgagtgaac cggtcttcag ccacgttcgt catctcgtca ttcactcgtt gagagctggc
     9781 tgccgtgaaa accctccccg agcgctacca agcccccaaa gcccgccccg caggccgttt
     9841 cgccaccgtc acccgcagct tcggccgcgg caaccgcgac gccatcctgc acggactccg
     9901 ccgccgctga acacacgatc accccgctac tgacccggcc ggaagccgag ccagcccaca
     9961 gccacgtccg tcgtccgaat cgaacccggt cggtgtgccg atgaacgcac tctcgagcag
    10021 tctcgtcgtc ctccccgact cgccggccgg caccgcgctg ttgccgcgag tcccttaccg
    10081 gcggccgagc gtcctgttcc attcctccgg ccggccgtgg ctggccggcc gctgggagcc
    10141 gggcgaaatc cgggtcgcca tcacgggccg ggcgcgcgtc gcggtgttcg ggttctgccc
    10201 gatgccggtc gagcggctga ccgcgtacac cgcccgcctc cggaccgtct ccgacgcgga
    10261 cgccctcgcc cgcgtcctgc ccggcagcgc gcacctcatc gcgtcggtga acgggcaaac
    10321 ccgcctgcaa ggcactctcg cgaacctgcg ccgcgccttc cacacccaaa tcggctccgt
    10381 cccgatcgca ggcacccgcg ccgacgtcct ggccgagatg accggagccg acctggacga
    10441 gaaccttctc gccgcgcacc tgacggaaat gcagcttctt ccgccgctga tcgagaaatc
    10501 ctggtggcgc acagtgcatt ccgtgccgcc ggactccgcg gtcgtgctga ccgacgacgg
    10561 accagccagc acggtgcgat ggtggcgccc gccggaaccg gacctgccga tccgcaaggg
    10621 cgctcccgcg gtccgcagcg ctttgcggga atcggtcgcg gaacgacgtc ctgcgcaagg
    10681 ccggttgtcg ctggatctgt ccggcggaat ggactcgacc acgctgtgtt tcctcgccgc
    10741 cgcgcagact cccgacctgt tcaccttccg gtggtccggc ggcagtgtcg ccaacgacga
    10801 tccgatcttc gccgccgaag ccgcccggct gctccccggc gtcgaacacc tggaacggtc
    10861 cgacgccagc gcgcccgcgt tgttcgcacc gccctacgcg acgggcgatc tcgaagcgcc
    10921 gtggacgatg acccgggggc tgaacggctc cgcccacggc gtgcgcgttc tcgccgagca
    10981 cggctcgggc ctgcacttgg ccggacacgg cggggacgag gtcttcagcg gatcggccgg
    11041 ctatctccac acgctggtcc gccgccgccc gctcaccggt ctgcggcagc tccgggtcta
    11101 ccgcagcctc ggccggtggt cgtggccgca aacccttgcc gcgctggccg accggcagag
    11161 ctggggcgac tggtggcgag attcggctga ccagctcacc gacccccttc cccgcccggg
    11221 gacaccggac ctcggctggg ccgatccggt ccgagccgcg ccgtgggcca ccggggacgc
    11281 gctcgcgacg acccgccggg tcctgtacga gatcgccgcc gaggccgtcc cgctcgccgc
    11341 cgaccgcggc cagcaccaag cgctgaccag cctgcgcgcc gccgggccgc tgtgccagca
    11401 gatccagcgc gagtacgccg ccgagggtgt cccgctcgac ctcccgtatc tggacgaccg
    11461 ggtcgtcgag gccgcactcg cggtccggac gtccgaccgc ttcacgccct ggcggtacaa
    11521 accgctgctc gccgacgcca tgcgcgggct cgtcccggac gtcatcctcg accgcaccac
    11581 caagggcaac taccaggacg atgacgacgc cgaggcgcac cggcacgtgc ccgacctgct
    11641 cgactacttc gccgattcgg ccttggcggc acgcggcctg ctcgacctcg acgcgttccg
    11701 cgcctgcctg ctcgaaccgc ggctggacga cgaggtggaa gcacacctgg aaaccgcgct
    11761 cggctgcgaa atgtggcttc gggcgatcgc cgacgcgcgg cccgcgaccg accggaggac
    11821 ccatgcacct gcaccctgac accgcgctca ccgacactcc ggacggctcg gtcctgctca
    11881 acaaacgcac cggacgctat tggcaggtca accggaccgg cacgcacact ctcgaccgcc
    11941 tgctcgccgg cgaaaccgcg gaccagatcg ccgccgacct cgctgcccgg tacgacatcg
    12001 acgccgccca agtgcaggcc gacatcaccg cgatgaccga aagcctgctc gccgccgggt
    12061 tggtcgaacc gtcgtgagcc agccgactgt ggtaccccac cgaattcgcc tgccactgca
    12121 tcgaaaactg ctgccgctgc tcatcgtcgg cctcgcgacc gtgctgaccg cgttgtcccc
    12181 caagcatctc tgcgcgatcc tgcgcttcgc ccgccgaggc gctcgccccg ccaccttcga
    12241 acaagcccgc ttcgcgcgtc gatcggtcgt cgcgatcagc ctgcgctgcg caggcgacgg
    12301 ttgcctgctc cgctccgtcg ccgccgcact gctgtgtcgc gtgcacggca cctggccgac
    12361 ctggcgcacc ggcgtgcgca cgcaaccctt cagcgcccac gcgtggatcg aagccgacgg
    12421 ccaggtcgtc gacgaaatcc atcccgcggg ttatttcgct ccgctgctga ccgtcgcccc
    12481 gctaaggact gcccggaatg accgtcaccg cccctgaaac cagtacgtcg gccaccgagc
    12541 agcccgcccg ttcccgggtg ggtctgcgcc atctcttcgc cgccacccgc gggcaccgca
    12601 gaaacatcgc cgtcgcactg cttttcaccc tggtcggtgc cggacttggc ttgctgcaac
    12661 caatgctggc catgcaaacc atcgacgccg tcggagccgg cggtgccgtc ggctggctgt
    12721 tagtcgcgct cgtaaccgtg ttcgtagccg aagccggcgc ggacaccatc ggccgttact
    12781 ggctggaacg ctccggcgaa ggcgtcgtac taggcctgcg agttcgcctg atcagccacc
    12841 tcctgcgctt gccgatgcga ctgtacgacc accaccgcat cggagacctg ctgtcccgaa
    12901 cgacggccga cacgaccctc ctgcgcgaca ccctcgccta cgacctggtc gaaatgctca
    12961 ccggcagctt cgtagtcatc ggcggcaccg ttgccatgct ctggctgagc cccctgctgt
    13021 tcggcatcgt ggctgtcatc gtcggcggtg tcggcggcgt aacgctgttt gtgctggcac
    13081 gcatccgaaa cgccaccgaa aacgcgcaag acaacctggg cctgatggct gcggaactgg
    13141 aacgagccct cagcgccatc cgcaccatcc gcgccacccg cgcggaagac cgggaaaccg
    13201 cccgcatcgg ccactacgcc cacacgacgt atcaagacaa cgtccgcgcc gcccgcctca
    13261 actcgatcgc cggcccagca gtaaccctct ccgcccacgg cgccctcatc gctgtgttgg
    13321 tgactggcgg aatccaagta gccaacggaa atctcaccct ggccgaactg gtggctttcc
    13381 tgctctacgt cagctacatc gccgtcccca gcgcaggcct gttcgaactg gccgccacca
    13441 tccaaagagg actggccgcg ttccagcgag tccacgacat gacccggctc cccaccgaaa
    13501 ccgaccacac tcccacgtcc ctggtttccc cagcctccgc accggtcctg gaactacgcg
    13561 acgtctggtt cagctaccac cccgaccgcc cagtactgcg cggcgtctcc ttcaccgtcc
    13621 cgcgccgagg ccatgtcgct ctggtcggcc cttccggagc cggaaaatcc acgatcctcg
    13681 cgctgatcga acgtttctac gaacccgacc gcggaaccat tctgttcaac ggataccagc
    13741 cgtcgatcgc cgaatgccgc cagagaatcg gcctggtaga acaaacaacc cccatcctgc
    13801 acggcaccct gcgcgacaac ctcacctacg ccgcccccga cgcgaccgac gagcagatcc
    13861 gcgacgtcct ggagaaaacc aacctcaccg aattcgtctc ccgtctcccc gccggactgg
    13921 aaaccccagc aggcgaacac ggcggcatgc tctccggcgg ccaacggcaa cgattggcca
    13981 tcgccagagc cctgctggca cgcccggaac tgctgctcct ggacgagcca acgtcccaac
    14041 tggacgcagc caacgaagcc gctttcgcgc agacgctgga tcaggttgcc ggagaatgcg
    14101 cgctactggt catcgcccac cgcccagcta ccgttcgacg agcgcagaca gtgatcgcct
    14161 tggagcaagg acggatcagc accgacgcgg gcctagtccc ctaacgcctc actctcctac
    14221 ctgcgaaaag cagcagactc acagccaaaa tcgcgccccc aagccacgcc agccccgtcc
    14281 cccacaaccc cgtgtagtga taaggccgct ccgattcggg gaccgtcacc gcgatctcgt
    14341 ccacccgatc ctggatctgc cgctgctcag cctcgctcaa cccgcctacc gcaaggccct
    14401 tgaccaagtc cccgatctca ccgttctgcg caggcgtgaa cccaggcaat gtcgtgctgc
    14461 cgccgaacga gaactgcgga tacgccgtgc aatccatcgc ctcaccggtg tcgacgctca
    14521 aatgcaagtg acgcttctcg tcgcaggcat caccctcatg cccaaactcg atccggtaag
    14581 cgtcatcgac gtcgccctgc tgaccgagcc cggtgatcag gcacccgaca ccggaaaaga
    14641 gcgccgccgc aagcagaacg cgagagacga cctgccgcgc tgaaatcctc atgacgcccc
    14701 agtctcagcc attcgcgcgg gaccggtccc gcttcgcata cggttgctgg gtgaccgatg
    14761 gcgagcagcc agacctggac gagatcgagg aacacttcgt cgcactgctc gacgggcgaa
    14821 ttacccgcga cgctgtcgac cgctgggccg gtcgctggct ggccgacgac agtctctcgt
    14881 gggatgagct gaactggtgg gccttgggtc ttcttcatgg aatcgacctg cgccacggcc
    14941 ccggcggcgc ctacctgcat gacgacagcc aggtacagga ttggctagcc gagttcagga
    15001 gccgccgcac ccggtaaccg ctcgataccg gctgcccatc gatcggccga cttcgaagat
    15061 caacgccccg gaagacggta gaagttctct catgcctctg ccctctcggt ccgccgcccg
    15121 actcgcgaca ctggccctcg cgctagccct caccagcggc tgcagccaga acccccccta
    15181 cgtccccgag ggctacgcca agatgatgaa gctccccgac atcgaccagg ccaaagccac
    15241 ctacaccgcc atggtcaccg ccatccgcga ccggctcacc gccgaattcg gccgcacttg
    15301 ggaaaaaggc tccgaagtca acagctatac ctgcggcatt ggctacatcg gtgttggctc
    15361 cgacagcttg aagctgcatc tgcccatgtg gaagtcgtcc ggcagcctgg ctgaggccga
    15421 ctggccccgt gcccaagccc tggtcgggca actcgccgcg ggctacggct tcagacccgc
    15481 tcctgaggcc aatcaacctg gcaaccacac catggggtac accgacccca acggcgcgat
    15541 gctgcacttc ggcaccggca acttcactgt catcgaggta acgacaggct gccacttgac
    15601 ggccgaagca caccgccgcg gcggccccac acacgattag acctcggcga aaccggctcc
    15661 gcgtcaagac ccacccggcg atcgaacgca gctgtctctg ctgaccgggc aagaacatcg
    15721 aggcgcacac ctggtgcagc gaaaacggtg cctctgacgg ggttcgaaca gcatccccac
    15781 gagcgccgcc tgctcgcaga gcagccatta atgccgcgcg aaaacagggt tcgactcgtc
    15841 cttccctcca ggctggcgat ctccggcaga tcggcgggca gtagcttgtc ctggaccgct
    15901 gcctcgtcga tgtactcaac cgggcacccc caattgcagg ggtctcgaac agacgacgga
    15961 gatgctctcc ttcccccgct tgccaggatc ggccctgtcg gcatcgtcaa gttcggtgat
    16021 agccgccggc actgccagcc agagtgtgct gcgcacgacc cgcctgacag ctagacttcc
    16081 gaacacgttc cgaatacgat ggggccatga tccccgcagc agacctttcc ggggcgactc
    16141 ggcgctcctc ggatctgagc aagcactcgg ccgaggtctt cgctgaggcc gaagaccacc
    16201 cagtgacagt gactcgccgt gacggcgagg cgctggtctt gatgtcgaag cgtgaggctg
    16261 aaggccgctc gcgactgctc gatttcgcag ctcagctcat caccgtcacc cttgacgacc
    16321 agggcacact ggctgaccgc atggccaagg tttttccatg gatgctggcg ctctcgcccg
    16381 cggaccgggc gtcgtgcgct caggacctcg tcgacgcggc gcgagcatcc ttttcgaccg
    16441 accagcctca tctggcgatc gccgagctga cgtcctggaa ggagacggct acggctgtcg
    16501 ctgcggggct gggccgcact gacctcgaat ggctcgacga ggacgaaacc gtggagcgtc
    16561 cctgaccgtg gcgtcggcca agaaggggga gctggtccct cgtccgccca agaagatcga
    16621 gtacgagatc cgcttcgcca ccactgacgc actgaagggc tggcgggatc tcgtggccac
    16681 cattcgcaat gcgatggcgg acacctggga ctttctgacg cggacgccac aggccacgac
    16741 gccgacgaat taccgtctga agggcgagct gaagaccgtc cagcggggcg gcaaatccta
    16801 tgcgcgctgg cagcacaagc caacggctgg agggtcagcg cgcatttggt tctacgtctc
    16861 agagcgcacg gtctatctcg agcaagtgca tacacatcat ccgaacgaga ccaagtaacc
    16921 gcggctgagt gtgtttttgc ctgctgttca agcgaaatca gcgcggcgca tgctcggacg
    16981 gctcgtgcgg tggccggcgc agtcctggcg tacgcggccc agcaaagcgc tatcggtgct
    17041 tgtcccggct gagcgaaagg cttcgctgca gaagttcgaa gcggacaagc aggctacggc
    17101 aaggatctgc cggatctgat gcgttggcct gcgacgcgtt aaccagctca agacggacaa
    17161 cggagaccgc aagctgccgg tgccttcccg gcgggtcgcg atgctgcgcg agcgactgtg
    17221 gatcgcccgg aagacagccg aggtcctacc agcccggcct tctcggactc gctgggcggg
    17281 attcgcggcc cttcgagtac ccggcgggac atccgcaaca agccgtcgat gacacaggac
    17341 gtgtacatgg accgctcgac ggtcccaccg gccaacgcca gcgcaccgga aagcatgcgg
    17401 ctcgacccag cctccggcaa ttccggggat aaaccggggg gttgctcttg gccgaacctc
    17461 ggaagagtcg tcctgaccag agaaaacggt gcccccgacg gggttcgaac ccgcactggg
    17521 tcgattttaa gtcgactgcc tctgccaatt gggctacggg ggcccaccca ccctagcgaa
    17581 ccccggccca tgcacgacaa agccgggccg cccgaagacg acccggcttc accaacgaac
    17641 ggctcaaccc ttgctggccc ggttgaactc ttccttcggg ttgttgatct gccccagcga
    17701 gatgacctcg cgccggaaca gcccgcccag catccagtcg aacaggatgc ggatcttgcg
    17761 gttccacgtc ggcatcgcct tgaggtggta ggcgcggtgg aagagccacg ccgggaagcc
    17821 cttgatcttc aggttcagcg cgtccgccac gcccttgtgc aggccgaggc tcgcgaccgc
    17881 gcccaggttc ttgtggtagt agtccttcgg ctgtccgccg cggatcacct tgatgatgtt
    17941 cttcgccagc aggcgggcct ggcggaccgc gtgctgggcg ttcggcgggc aggtcgccgt
    18001 cgggtcctgc tcggtgcgcg agaggtccgg gatcgccgcg ttgtcgcccg cggtccagac
    18061 gtccgggtgg ccgactacct gcatcgcggc ggtggcctcg acgcggccgc gcttgtcgag
    18121 cggcaggtcc gaaccggcga ggaccgggtt ggccttcacg cccgcggtcc agatgatcgt
    18181 gtcggtgtcg aactcggtgc cgtccgagag cacgacgtgg ccgttttcga acgacttcgc
    18241 cgcggttgac aggtagacct cgatgccgcg cttctccagc tgctgcaccg tgtacacgcc
    18301 cagcgtctcg cgcacctcgg gcaggatccg cccggccgcc tcgaccatca cccagcggat
    18361 gtccgcgggc ttgatgttcg ggtagtagtt ctcgaccgcg aagcgggtca tgtcctcgag
    18421 ctcggccagc gcctcgatgc ccgcgaaccc gccgccgacc acggtgaacg tgagcaggcg
    18481 cttgcgcagc tcgggatcga gcgtgctggc ggcttcgtcc agcttggtca tgatgtggtt
    18541 gcgcaggtag atcgcttcgc cgatggtctt gaaggcgatg ccctcctcgg cgaggccggg
    18601 gatcggcagg atccgcgcga cggcgccgag cgcgaccacg agcacgtcgt agttcagcgt
    18661 ctcgatgtgg ccgtcggccg cctcgaccgt gacggccttg cgctcgttct cgatcttcgt
    18721 gacccgcgcg gtcagcacgt ggcagcgctt cagcacgcgg cgcagcggca cgaccacgtg
    18781 ccgcggctcg atcgcgccgg ccgccgcctc gggcaggaac ggggcatagg tcatgtgcgg
    18841 ctgcgggtca acgacggtca cggaggcctc gttggcacgc agcatcttct gaagcccgta
    18901 cgcggtgtac aggccgacgt atccaccacc gaggacgagg atccgagtcg gttccgactt
    18961 cgcagcagcc atgtacctat agtcgcactt ccgaagcggc tccgctcggg taccccaccc
    19021 cgctgtgacc agcatcgcca cgctggttgt cacgattcag atgaggccag ccgccgaggc
    19081 cgcggcggtg aacgcggtca ccaccatggg ctgtgtcaca cgaccggtct ggacattgcg
    19141 cggtgacacg tggtagcagc cgaacaccgc gaggtcgccg acctgcatcc gggcgccgtg
    19201 cgcgaaggcc ggacgcggtt tcggcaccgg ccagcccgcg gcggacagca ccggcagcag
    19261 cgcctgccag ccgaacgctc cgagcacgac gatcgagcgc agggtcggcc gcagcaggtc
    19321 cagttcgtcg gccagccagt ggcggcaggt gtcccgttcg gcgggggtcg gccggttctc
    19381 cggcggcgcg cagcggaccg gcgagacgag ccgggtgccg cgcagcgtga gcccgtcgcc
    19441 gatggcggcc gacaccggct gcgaagcgag accgacctcg tacagcacgc ggaagaggaa
    19501 gtcgccggac ggatcgccgg tgaacatccg gccggtgcgg ttggccccgt gcgcggacgg
    19561 cgcgagcccg accacggcca gcgcggcgtc ctccgcgccg aagccgggga ctggccgcga
    19621 ccaatacctc tcgcctgcga acgcggcctt cgtcccggcc acgccctcgc gccattcgac
    19681 gagcctcggg cacgcgcggc attcgaccag ggaagcgtcg aggtcagcga acgtgcgcat
    19741 tgcgccaatc taaccgggtc acgagataag ttggggccat ggccgacacc accgcggacg
    19801 agaccgccga gaagaccaag gacgaggaga cgaaggcggc ggagcccgtc gacgacctcg
    19861 tcacgacgca gcacaccctc accgtcaagc ggcgcaagct cgcctacacc gcccagaccg
    19921 gccggatcgt gctccgccaa gaggtcaaga aggacggcaa atccgagggc taccaggcca
    19981 aggccgaggt tttcctcacc gcctacaccc tcgacgacgc cgaccccggc acgcggccgg
    20041 tcaccttcgc cttcaacggc ggccccggtt cctccagcat ctggctccac atgggcctgc
    20101 tcggaccgcg ccgggtgctg tccggcgacg tcaacgaccc ggtgccgccg ccgtacgggc
    20161 tcgaggacaa cccggaaagc ctgctcgcgc acagcgacct ggtgttcatc gacccggtcc
    20221 agaccggcta ctcgcgggtg accgagggcg gcgaatccca gccgtacacc gggttccagg
    20281 gcgacgtcga atcggtcgcg gagatcatcc ggctgtgggt ttcgcgcaac cagcgctggc
    20341 tgtcgccgaa gttcctcgcc ggcgagtcgt acggcacgct gcgcgccgcc gcgctggccg
    20401 ggcatttgca ggagcgctac ggcctgtacc tcaacggcct gatgctcatc tcgtccgttt
    20461 tggacctcgg cacgttgcgg ttccacgagg gcaacgacct gccgtactcg ctgttcctgc
    20521 ccacgtacgc ggcgatcgcg cactaccacg gccggcacgg cgaccgtccg ctcgacgacg
    20581 tgctcgccga cgccgaggac ttcgcctcga aggaactgcc gtgggcgctt tcccgcggcg
    20641 cgcggctgtc cactcaggac cgcaccgagg cggtgcagac actggcgtcg ctcaccgggc
    20701 tcagcgagtc ctatgtggac cgggtgaacc tgcggatcga gcacatccgg ttcttcaccg
    20761 aactgctgcg cgaccagggc aagaccgttg ggcggatgga cggccggttc accacgtggg
    20821 aaccggacgg cggcgtcgag cacatgagcg acgacccttc ggtgtcgcgg atcatcggag
    20881 cctactcggc cggcttcaac cactacgtgc gcgccgacct cggctacgag aacgacctgc
    20941 cgtacgagat cctgtcctcc gacgtgttca agtcctggtc ctacaaggag ttcgagggcc
    21001 gttcagtgtc cgttgtggac acgctgagcg cggcgatgcg ggccaacccg cacctgcaag
    21061 tccacgtcgc cttcgggcac tacgacggcg cgacggcgta ctacgcgtcc gagtacgtgc
    21121 tttcgcagct gaagattccg gaggagctgc gggagaacat cgacacggct tactacccgg
    21181 ccgggcacat gatgtacgtg cacgaaccgt cgcgggtgca gcagtcgaag gacctgggca
    21241 agttcgtgaa gaaggcgtcc aaccgctgac ctcgtgagtg cctatgccgg tcagaaccgg
    21301 cataggcact cacaaccagt cgtgctcccg cgcataccgc gccgcctcgt gccgcgtccg
    21361 cgtctgcgtc ttctgcatcg cgttcgacag atagttccgc acggtcccct ccgccagatg
    21421 cagttgcgtc gcgatgtccg cgaccgaata cccctcccgc gtcgcccgca gcacgtcgat
    21481 ttcccgcacg gtcaacgggc agtcgtccac caccgccagc gccgagacgt ccgggtcgat
    21541 ccagcgtttg ccctcgtcca gcgtccggat caccgccgcg atgtgcgccg gttccgccga
    21601 tttgctgacg aatccctgca cgccgagctt caacgccttg cgcagcactc cgggccgggc
    21661 gtgccgggtc agcatcagga tcacctgctc cggccgttcc cgccggatcc gcgcgaccgc
    21721 gcccagtccg tccacattgg gcatctccag gtcgatcacc agcacgtccg gccgatgctc
    21781 cacagtggcc cgcaccgccg cctcgccgtc ttcagcttcg gcgagcacgg tgatctcgtc
    21841 ctccatcggc agcaacgcag ccatcgcctt gcggagcagg gcttcgtcgt cggcaagcac
    21901 caccgtcgtc atcgcgccac cttctccggg aaggccgcgg ccgtcacgaa tcggccgtcc
    21961 ttctgctcca cggtcaattt tccgccctga tccgccagcc ggtccgccaa tgtggacagt
    22021 ccgctcagca ccgtttcctc gcgctccgga acgccgtcgt tgacgatgct gatccccgtt
    22081 tcggtcaacg tgatccgcac ctgccgggcc tgcgcgtgcc ggaggatgtt cgtggcggtc
    22141 tcacgcagca cctgaccgag cagctcgtcc gcacccgagc tgacctgtgc gagccgatcg
    22201 atccgcacgt ggattcccgc cgcctcgaag aggttcttcg cgttctccag ctccgcggac
    22261 aggttgagcc tgcgctgggc gtaagcgagt tccttggtct gcacgatggt ttcgccgacc
    22321 agggtgtgca cctcgcgcaa ttcctcttgc gcgcgttcga gatcccggtg cagcagcttc
    22381 tccgcgagcg cgaccttcag cttgaccacg tgcagcgtat gcccctggat gtcgtgcagt
    22441 tcgctggcga accggacgcg ctcccggacc accgccagtt cggcttcctt cccccgggac
    22501 tcctccagtt ccgcgac
//
