LOCUS       NZ_CP091381            22068 bp    DNA     circular CON 18-AUG-2024
DEFINITION  Amycolatopsis sp. FU40 chromosome, complete genome.
ACCESSION   NZ_CP091381
VERSION     NZ_CP091381.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. FU40
  ORGANISM  Amycolatopsis sp. FU40
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 9944196)
  AUTHORS   Reisman,B.J. and Bachmann,B.O.
  TITLE     Biosynthesis of Apoptolidin Family Glycomacrolides
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9944196)
  AUTHORS   Reisman,B.J. and Bachmann,B.O.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-2022) Chemistry, Vanderbilt University, 1234
            Stevenson Center Drive; Room 7330, Nashville, TN 37235, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 23-JAN-2022
            Assembly Method                   :: Flye v. 2.9
            Assembly Name                     :: NFU40_flye_2.9
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 47.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_021903635.1-RS_2024_08_18
            Annotation Date                   :: 08/18/2024 04:30:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,491
            CDSs (total)                      :: 9,417
            Genes (coding)                    :: 9,360
            CDSs (with protein)               :: 9,360
            Genes (RNA)                       :: 74
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 7 of 57
            Pseudo Genes (incomplete)         :: 50 of 57
            Pseudo Genes (internal stop)      :: 5 of 57
            Pseudo Genes (multiple problems)  :: 5 of 57
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:13:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5189149
            Orig. end                         :: 5211217
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP091381.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Brian O. Bachmann,
            Vanderbilt University.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22068
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="24"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22068
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22068
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12068](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12068)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     gene            complement(1312..1866)
                     /locus_tag="L3Q65_RS24665"
                     /old_locus_tag="L3Q65_24660"
     CDS             complement(1312..1866)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009154009.1"
                     /locus_tag="L3Q65_RS24665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24660"
                     /product="manganese efflux pump"
                     /protein_id="WP_182896911.1"
                     /transl_table=11
                     /translation="MNLEFLPLVALAFGLSLDNFRSSIAIGTIPFGWRRAVQVALVFGL
                     WDALGPLLGGVAGRYLGEFVGDWGEYVGVAALGLYGLYFLVSAIRNPETEADDLDHPWV
                     TLFGLPFSLTVDNFLAGAGLGIAGFSLVIPMFTFGAMTVVLSLAGLFVGRMAAKVIRIR
                     ADLLSGISLVGAAILLPLAFD"
     misc_feature    complement(2145..2162)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.73"
                     /tool="antismash"
     gene            2345..2815
                     /locus_tag="L3Q65_RS24670"
                     /old_locus_tag="L3Q65_24665"
     CDS             2345..2815
                     /EC_number="5.3.1.6"
                     /GO_function="GO:0016853 - isomerase activity [Evidence
                     IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011873333.1"
                     /locus_tag="L3Q65_RS24670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24665"
                     /product="ribose-5-phosphate isomerase"
                     /protein_id="WP_182896910.1"
                     /transl_table=11
                     /translation="MRIYLGSDHAGLELKNHFAERLSGLGYEVTDVGPAVYDAADDYPP
                     FCVETARRVVADEGSLGIVIGGSGNGEQIAANKVPGARAALAWNEDTARLARRHNNALL
                     AGIGARMHTVEEAERIVDAFLTAEFEGGRHQRRIDLLAEYERTGEPPALPGK"
     gene            complement(2917..3942)
                     /locus_tag="L3Q65_RS24675"
                     /old_locus_tag="L3Q65_24670"
     CDS             complement(2917..3942)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020661092.1"
                     /locus_tag="L3Q65_RS24675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24670"
                     /product="HAD-IIA family hydrolase"
                     /protein_id="WP_237596772.1"
                     /sec_met_domain="HAD_2 (E-value: 0.00035, bitscore: 19.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEAGPLLARYRGLICDLDGVVYRGASAVPHAVETLNEAAERGLS
                     VVFATNNASRPPGDVADHLRELGLAGTGWSVVTSSQAAAAYLAERLAPRARVCAVGGPG
                     VAHALAEAGLTPVRVADLAGAPVEAVVQGLGHDITWRELAAVGYLAEAGAAWVATNIDR
                     TLPTPYGKAPGNGALVALVQTATSASPHVVGKPKAALFDLARARLGTAPPDTLVCGDLL
                     GTDIEGANAAGLDSLFVLSGSSRLRDLAFAPRRSRPTYVAADVSGLLVPALPLDSASAE
                     RLDGLGPDGVPDLPSGGDSGRLLQAVIAGAWAARADGRPISDDARLWERIEQQLGVAGP
                     Q"
     gene            complement(3935..4915)
                     /locus_tag="L3Q65_RS24680"
                     /old_locus_tag="L3Q65_24675"
     CDS             complement(3935..4915)
                     /EC_number="3.1.3.11"
                     /GO_function="GO:0042132 - fructose 1,6-bisphosphate
                     1-phosphatase activity [Evidence IEA]"
                     /GO_process="GO:0006071 - glycerol metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006094 - gluconeogenesis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009154006.1"
                     /locus_tag="L3Q65_RS24680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24675"
                     /product="fructose-bisphosphatase class II"
                     /protein_id="WP_237596773.1"
                     /transl_table=11
                     /translation="MKSQEWGLAAAETARRPDDALALELVRGTEAAALAAGRWAGHSDD
                     SARLAAIDAMHTSLRSVAMDGVVVLGVGTQDDSPALFHGAEVGAGDGPVCDIAISIGDG
                     ALSEARDVPRALTAVAVSARGAMADLAPQHSIEKLAVGPGLADVVDITRPVAENLRRIA
                     VAKGVRVSDVVVATLNRRRHVELAREIQDAGARVHLVEGGEIAGAVAAARPEHPIDVFL
                     CTGNAVEGVVAAAALSCLGGSMQARLVPEGPAQQPAAVTRTEDLVGKESVVFCASGVTT
                     SELLRGVRNDGEGCTTTRSLVLCSDPDTVRTIQSEHRYVRERGRG"
     gene            complement(5013..5990)
                     /locus_tag="L3Q65_RS24685"
                     /old_locus_tag="L3Q65_24680"
     CDS             complement(5013..5990)
                     /EC_number="4.1.2.13"
                     /GO_function="GO:0004332 - fructose-bisphosphate aldolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010228265.1"
                     /locus_tag="L3Q65_RS24685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24680"
                     /product="class I fructose-bisphosphate aldolase"
                     /protein_id="WP_182896907.1"
                     /transl_table=11
                     /translation="MSTLNKIARIMVSDRRGILAADESIGTMSSRLEGVGVEATEENRR
                     VYRELIVTTPKLPESVSGIILADETFHQKLSNGQTFPQFLADRGILAGIKVDTGAKPLA
                     GAPGENVTEGLDGLRDRVKNYAALGATFAKWRATITIGDGLPSDRAVRANVHALARYAG
                     LCQEGGIVPIVEPEVLMDGSHSLAKCKQVTTSVLRSLFDELSLMQVQLDGIVLKPNMVV
                     AGKDCPEQPSVEEVAKATVDALRETVPSFVPGIAFLSGGQSPEKATEHLAAMQTLGPLP
                     WELTYSFGRALVGPALETWRGDESKREAAQKALSDRAVANAAAR"
     gene            complement(5977..6972)
                     /locus_tag="L3Q65_RS24690"
                     /old_locus_tag="L3Q65_24685"
     CDS             complement(5977..6972)
                     /GO_function="GO:0001216 - DNA-binding transcription
                     activator activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020661095.1"
                     /locus_tag="L3Q65_RS24690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24685"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_237596774.1"
                     /transl_table=11
                     /translation="MVLPSKMPQLADLDLLLSVERYGSVGKAAQAHSLSQPAASIRISA
                     MERRLGLRLLERSPTGSKLTEEGEMLAKYARNVMHAARELLEFGSGSSSASRLRVAGSP
                     GVSEHLIPEWLNRSGLSFGEVRVEVRTGRVDELRQLIRADQADVAFIDGWCQAGSQLPK
                     QFREGLVTRYICDDKLAVVVGAVHPWAKRPGPVTVEELASAQLVVRERGSGLREFTDEL
                     LGSARASRSYVELPSSAAVKQVVAAGRRVTVLNISTVRSEIADGRLRLVPVEQEMPAKP
                     IYAAWSERRGLPGHAKELVEIAAAKGSPMPGPQPGPKVTSTGGVTTDVHS"
     misc_feature    complement(7356..7371)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.87"
                     /tool="antismash"
     gene            complement(7505..9997)
                     /gene="pepN"
                     /locus_tag="L3Q65_RS24695"
                     /old_locus_tag="L3Q65_24690"
     CDS             complement(7505..9997)
                     /EC_number="3.4.11.2"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008237 - metallopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene="pepN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020661096.1"
                     /locus_tag="L3Q65_RS24695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24690"
                     /product="aminopeptidase N"
                     /protein_id="WP_237596775.1"
                     /transl_table=11
                     /translation="MSLAGTKLTEEEASARSAAVSHVRYEVELDLTTGEDEFATTTVVR
                     FRAEPGELFLDFAGTAASVECNDRELGPAAQAGARIRLIARPGENTVRVAGTAPYSRTG
                     EGLHRFRDPLDGQVYLHTKFEPFAAHTVFACFDQPDLKAAVGVTVTAEDHWTVVANTDP
                     EKLVPLEGDRTSWRFGPTPPLPTYLVAFAAGPFRRVQALHDGLPLGLYARNSLYCALTR
                     QAPELFDVVRRGLDFYRRLFDLPYPFAKYDHVFAPEYAFGGMEHPGCVTLNERFLFRHR
                     VTEDTRRRRAELLTHEMAHMWFGDYVTMRWWDDLWLNEAFATMMSVVAQPEATRYGEGW
                     TGFAHHNLPLARHADQLPTSHAIRVATPDTDAARSNFGPIVYRKGAAVLRELAERLGWD
                     SFVAGVRIYLRTHAWGNADLGDFAAALQRASGEDVGRWVEEWLLSSGVNTVEMVRDLLV
                     QHADVPPRRLNLRVAAFDDREGEMVLRRRAHVSLDSGECELAGFGDADLVVPNDDAVSH
                     VKIRLDARSRQKALASLSAVDDQRVRAVVWGALWDEVLDARLPARSYAAAVLAHGPGES
                     DAGVLEALLDRAVRAVRVYGDPSRRTEMLATLAHQVRTLLAAEAAGSDRQLVFARALVG
                     VVPDGEHRLLSEIAYGRSPWAGLEVDRDLRWRAVFRLASTGHDLDGCLDVAVEADPGDS
                     GRRNALTAEAARPAAAAKETGWERLFNGEFSLAERKAVMAGLPQPGQEGLLTPYADRYL
                     RTLESMPGTVEPEFAVAFARALYPHFTTAEQSVLAGTGRLLESTLLPRNVVKVLREERT
                     ELLIMRAARACDAAHRTR"
     gene            complement(10001..11101)
                     /gene="pqqE"
                     /locus_tag="L3Q65_RS24700"
                     /old_locus_tag="L3Q65_24695"
     CDS             complement(10001..11101)
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010228268.1"
                     /locus_tag="L3Q65_RS24700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24695"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_182896905.1"
                     /sec_met_domain="PTHR43273 (E-value: 2.7e-30, bitscore:
                     104.6, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.2e-19, bitscore: 69.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 7.4e-06, bitscore: 25.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 4.3e-11, bitscore:
                     42.1, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.2e-10, bitscore: 40.7,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGLPQPYGLLAEVTHQCPLHCVYCSNPLNLLDRQEELATEDWLR
                     VIREAAGLGVVQVHFSGGEPLVRGDLETLVAECRGLGLYTNLITSGLGLTEGRAEALVA
                     AGLNSAQLSIQGDAAESTNLVAASKRFDKKEAAARIIRDAGLPLNMNVVLHRLNLDRLD
                     AIIDVCAEWGAERLELANSQYYGWALRNRERLMPSKAQLDDAVAVYERRKAELGERMEL
                     LWILPDYYEPYPKPCMGGWAQNALTVAPDGTVYPCPVAAEITTMAFSSVRDHDLEWIWT
                     KSEAFQAFRGTAWMPDPCQSCPRKEIDFGGCRCQAFALTGDAARTDPVCQHSPDHHLVQ
                     DALVRANHSNGEAADLVYRRPAARRH"
     gene            complement(11098..11373)
                     /gene="pqqD"
                     /locus_tag="L3Q65_RS24705"
                     /old_locus_tag="L3Q65_24700"
     CDS             complement(11098..11373)
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020661098.1"
                     /locus_tag="L3Q65_RS24705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24700"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_182896904.1"
                     /sec_met_domain="PqqD_RRE (E-value: 3.2e-21, bitscore:
                     73.9, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 9.5e-13, bitscore: 47.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNESELAAVPKLATKAMLKHDNVRDVELLLLPERVVLLNKSGAAI
                     LGLCDGSRTVRQVVDQLERDFQAADLANDVMKFLHDARGRGWVVVA"
     aSDomain        complement(11110..11358)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_L3Q65_RS24705_PqqD_RRE.1"
                     /evalue="9.80E-24"
                     /identifier="RREFam006.1"
                     /label="L3Q65_RS24705"
                     /locus_tag="L3Q65_RS24705"
                     /protein_end="88"
                     /protein_start="5"
                     /score="73.9"
                     /tool="antismash"
                     /translation="LAAVPKLATKAMLKHDNVRDVELLLLPERVVLLNKSGAAILGLCD
                     GSRTVRQVVDQLERDFQAADLANDVMKFLHDARGRGWV"
     gene            complement(11373..12068)
                     /gene="pqqC"
                     /locus_tag="L3Q65_RS24710"
                     /old_locus_tag="L3Q65_24705"
     CDS             complement(11373..12068)
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020661099.1"
                     /locus_tag="L3Q65_RS24710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24705"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_182896903.1"
                     /sec_met_domain="TIGR02111 (E-value: 5e-90, bitscore:
                     300.1, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVRSAEEFEAYLRSIGEKRYHHLHPFNERMHAGELSEAEFRGWV
                     RNRFYYQMNLPKKDAFILTKLPGRDDRRRWITRITDHDGRTGGEGGLEKWVRLGKAVGL
                     SREELYDVDTVLPGVRFAVDAYVDFCRQKPWLEAVASALTELFAPDLLSRRITDVQRHY
                     PWIAAEGLEYFRARLTQQPKDIAHLLELVVENAKTEQQQEACARALEFKCDVLWSLLDA
                     VELAYRKSS"
     gene            complement(12065..12967)
                     /gene="pqqB"
                     /locus_tag="L3Q65_RS24715"
                     /old_locus_tag="L3Q65_24710"
     CDS             complement(12065..12967)
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020661100.1"
                     /locus_tag="L3Q65_RS24715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24710"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_182896902.1"
                     /transl_table=11
                     /translation="MLIHCLGAAAGGGYPQWNCACAGCVKARAKPEHATAHAGIAVSGD
                     GERWFLFNATPDVLHQIAADPVLHPGPGIRETPVAGVVLTDAEFDHTIGLLMLREESSL
                     TVHGTFPVLEALNLWFPVRELLSDYADISWSEVRAGEPVDLDDRVRATAFLTGSKAPRY
                     VGNSQLREQPAEWEVGYRLEDKLTGGIAVYAPTVPRWDEKFEQQVASADCVFVDGTFWT
                     DDEMSATGAGNRTGRSMGHLPVSGDGGSARALAALPAKRKIYTHINNTNPILDEESPER
                     RWVTDLGIEIGRAGLEVEV"
     gene            13504..14130
                     /gene="hxlA"
                     /locus_tag="L3Q65_RS24720"
                     /old_locus_tag="L3Q65_24715"
     CDS             13504..14130
                     /EC_number="4.1.2.43"
                     /GO_function="GO:0043801 - hexulose-6-phosphate synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0019647 - formaldehyde assimilation via
                     ribulose monophosphate cycle [Evidence IEA]"
                     /codon_start=1
                     /gene="hxlA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020661081.1"
                     /locus_tag="L3Q65_RS24720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24715"
                     /product="3-hexulose-6-phosphate synthase"
                     /protein_id="WP_182896963.1"
                     /transl_table=11
                     /translation="MRLQVALDVLDVGSALALARQVAGEVDILELGTPLVKSAGISAVT
                     AVKAAHPDKLVFADLKTADAGELEATLAFEAGADLVTVMGAADDDTVRGAVAAGRKYGK
                     EVVADMISVTEGRVARIREVAKLGVSFVEIHAGLDEQARPGYSIDTLLADGREAGVAFS
                     IAGGVKAATIGLVKDAGAAVAVVGGGIYNAPDPAAAARELRRLTA"
     gene            14166..14435
                     /locus_tag="L3Q65_RS24725"
                     /old_locus_tag="L3Q65_24720"
     CDS             14166..14435
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020661102.1"
                     /locus_tag="L3Q65_RS24725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24720"
                     /product="hypothetical protein"
                     /protein_id="WP_182891520.1"
                     /transl_table=11
                     /translation="MEVQNPAAGSTYGSLLLQAAGVLRLRYVECRRDTSLSPEAAAELA
                     TVFEALAQGEPAFDQIDPKEAIALANRLIDDDHPELSHLWPTTR"
     gene            14476..15090
                     /locus_tag="L3Q65_RS24730"
                     /old_locus_tag="L3Q65_24725"
     CDS             14476..15090
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020661103.1"
                     /locus_tag="L3Q65_RS24730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24725"
                     /product="GPR1/FUN34/YaaH family transporter"
                     /protein_id="WP_043840322.1"
                     /transl_table=11
                     /translation="MTTAEATEAPARTIPEGDPALIGVPTFIVGATALGLVLTGYVPAG
                     AVGASIAIILPATGLGQLVAAVWAAAQGQSAVASVFGIFAGFWLSYAVLVLGLTHNWFG
                     IPADAAVSTQGLFLTAWLVMIVLLTLASLRLPAAFTLLFALIDLALALVLFGTVNGSAG
                     LTTVGGYVVFAFTAVGVYLFLGAMSAATGGRSLPLGRPVLS"
     gene            15152..16354
                     /locus_tag="L3Q65_RS24735"
                     /old_locus_tag="L3Q65_24730"
     CDS             15152..16354
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020658681.1"
                     /locus_tag="L3Q65_RS24735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24730"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_237596776.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 3.2e-57, bitscore:
                     193.1, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSPTFVVIGAGLAGAKGAEALRDKGFDGRIVLIGDEEHLPYERP
                     ALSKDYLSGNASRDSLYVHDATWYAEQRIELRPGVRATGIDRAAHEVRLSDGTSLSYAK
                     LLLATGASARTLPGATGVRYLRRLEDSDWLKGLFTTAGSMVVLGAGWIGLETAAAARRA
                     GLDVTVVEALPQPLVPALGREVAAVFTDLHLQHGVDLHLGVQVDQVERGKRVKLADGTV
                     LEADAVVAGIGAQPNTGIARACGLRAGNGVLVDASLRTSDPDIFAAGDVANAYHPQLRR
                     HVRVEHWANALNQPAVAAAGMLGKNDVYDELPYFYTDQYDLGMEFLGTIDSYDRVVFRG
                     DVPGREFIAFWLKDDRVLAGMNVNVWEVTEPIKALVRSRRPIDPDLLADPDVPLDRLAA
                     P"
     misc_feature    15215..15217
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(16410..17042)
                     /locus_tag="L3Q65_RS24740"
                     /old_locus_tag="L3Q65_24735"
     CDS             complement(16410..17042)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170: metallo-beta-lactamase family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016335040.1"
                     /locus_tag="L3Q65_RS24740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24735"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_237600936.1"
                     /transl_table=11
                     /translation="MVSGLRIERVVTSGVFELDGGSWAVDNNIWLVGGDEEVVIVDAAH
                     DEKAITDAVDGRNVVAVVCTHGHNDHVTVAPALAANLHAPVLLHPGDQELWEMTHPDRK
                     FWPVQDGERIAVAGTELRVVHTPGHSPGSVCLYLPEAGALFSGDTLFSGGPGATGRSFS
                     DFPTIVSSIRDRLLELPAATKVHTGHGDATTIGDEAPHLSEWIARGH"
     gene            complement(17036..18121)
                     /locus_tag="L3Q65_RS24745"
                     /old_locus_tag="L3Q65_24740"
     CDS             complement(17036..18121)
                     /EC_number="1.1.1.306"
                     /GO_function="GO:0050607 - mycothiol-dependent formaldehyde
                     dehydrogenase activity [Evidence IEA]"
                     /GO_process="GO:0010127 - mycothiol-dependent
                     detoxification [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (25-257). E-value: 1.3e-10.
                     Score: 32.8. Matches aSDomain:
                     nrpspksdomains_L3Q65_RS24745_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017982692.1"
                     /locus_tag="L3Q65_RS24745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24740"
                     /product="S-(hydroxymethyl)mycothiol dehydrogenase"
                     /protein_id="WP_237596777.1"
                     /sec_met_domain="ADH_N (E-value: 1e-26, bitscore: 92.0,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.8e-27, bitscore:
                     95.0, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQQVRGVIARSQGSPVELTDIVIPDPGPGEVVVAVAACGVCHTD
                     LTYREGGINDEFPFLLGHEAAGTVESVGAGVDSVRPGDFVVLNWRAVCGQCRACKRGRP
                     QYCFDTFNAAQRMTLADGTELTPALGIGAFADKTLVHAGQCTKVDSSADPAVAGLLGCG
                     VMAGLGAAVNTGAVGRGDSVAVIGCGGVGDAAIAGSRLAGATTIIAVDRDERKLEWARD
                     LGATHAVNASETDTVAAVRELTGGFGADVVIDAVGRPETWQQAFYARDLAGTVVLVGVP
                     TPDLRLEMPLIDFFSRGGALKSSWYGDCLPERDFPMLIDLYRQGRLPLEKFVSERIGLA
                     DVEKAFHAMHAGDVLRSVVVW"
     CDS_motif       complement(17285..17317)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_L3Q65_RS24745_0002"
                     /evalue="1.00E+00"
                     /label="PKSI-ER_m2"
                     /locus_tag="L3Q65_RS24745"
                     /protein_end="279"
                     /protein_start="268"
                     /score="3.0"
                     /tool="antismash"
                     /translation="RDLAGTVVLVG"
     aSDomain        complement(17351..18046)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_L3Q65_RS24745_PKS_ER.1"
                     /evalue="1.30E-10"
                     /label="L3Q65_RS24745_PKS_ER.1"
                     /locus_tag="L3Q65_RS24745"
                     /protein_end="257"
                     /protein_start="25"
                     /score="32.8"
                     /tool="antismash"
                     /translation="DPGPGEVVVAVAACGVCHTDLTYREGGINDEFPFLLGHEAAGTVE
                     SVGAGVDSVRPGDFVVLNWRAVCGQCRACKRGRPQYCFDTFNAAQRMTLADGTELTPAL
                     GIGAFADKTLVHAGQCTKVDSSADPAVAGLLGCGVMAGLGAAVNTGAVGRGDSVAVIGC
                     GGVGDAAIAGSRLAGATTIIAVDRDERKLEWARDLGATHAVNASETDTVAAVRELTGGF
                     GADVVIDAVG"
     CDS_motif       complement(17903..17941)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_L3Q65_RS24745_0001"
                     /evalue="5.10E-03"
                     /label="PKSI-ER_m2"
                     /locus_tag="L3Q65_RS24745"
                     /protein_end="73"
                     /protein_start="60"
                     /score="9.9"
                     /tool="antismash"
                     /translation="LGHEAAGTVESVG"
     gene            18271..19527
                     /locus_tag="L3Q65_RS24750"
                     /old_locus_tag="L3Q65_24745"
     CDS             18271..19527
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020661107.1"
                     /locus_tag="L3Q65_RS24750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24745"
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_237596778.1"
                     /transl_table=11
                     /translation="MPADPRAAVDLPGLRDVVDGPLHDIAGRFSRFLAETWPHCALVIF
                     TKECTGRPRKVAGDAETTDKIAIAELEALKAAVHPGRATSTTAQLGGAARPVWAVHDPI
                     GTLLVLIPRTVRKPVPRPVPLAELFGIVATSIRQQVTQASPDYLTESRAASSERARTIV
                     EMAATQERTLVTVLNALRSTKLDAEGARAAATDAASAALVALRSAHKTDLALSEEPVHT
                     AFARLRREVRQVLRHHDAELEFVEPQPDTRPLCGELAPAARAMTCTAVLAFTAQPTLTR
                     LRVAWSCDDSSLRLDIRDHESGRLDVDALHLQLDGRAKALGGSVEVDAVSGWGSRVSIV
                     LPRSVARDSTDTTSLSKLNRRELEVLRHVAHGLRNKAIAERLGITESTVKFHVANVLKK
                     LKTGSRGEAAVLALNAGVA"
     gene            complement(19564..19926)
                     /locus_tag="L3Q65_RS24755"
                     /old_locus_tag="L3Q65_24750"
     CDS             complement(19564..19926)
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025063.4"
                     /locus_tag="L3Q65_RS24755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24750"
                     /product="transposase"
                     /protein_id="WP_237596779.1"
                     /transl_table=11
                     /translation="MDSLWFLIRDRDAKFTAAFDAVFASVGIDVLRSLVRVPRANAIAE
                     GWVGSGRRECLDRLFIVNRPHLEQVLAEYVNHRRPHRSLGRRPPERQVPVRMRDAGLVR
                     RHGRLGGLIYEYQQVA"
     gene            complement(19905..20471)
                     /locus_tag="L3Q65_RS24760"
                     /old_locus_tag="L3Q65_24755"
     CDS             complement(19905..20471)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="L3Q65_RS24760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="L3Q65_24755"
                     /product="hypothetical protein"
                     /protein_id="WP_237596780.1"
                     /transl_table=11
                     /translation="MRFLYLLVTRVFGWLVLCSRSNAAKDAEILVLRHQLAVLQRQASR
                     PRLTWADRAVLTALVRRRWTYGSRPGRPAVAVVIRRLVGEMARDDPGWGYRRIHGELVG
                     LGYTIAPSTMWKILKDGGVDPPPRRSGPTWKQFLTVQASGILAMDFFHVETVLLRRLVR
                     LRSGWCSRPGTCWLNSATEWTVCGF"
     gene            20748..21158
                     /locus_tag="L3Q65_RS24765"
                     /old_locus_tag="L3Q65_24760"
     CDS             20748..21158
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015928.4"
                     /locus_tag="L3Q65_RS24765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24760"
                     /product="peptidase inhibitor family I36 protein"
                     /protein_id="WP_043838119.1"
                     /transl_table=11
                     /translation="MPTIRSAVALAAAVAGAAAGTVLAAAPASAATAPCPAGYYCFYQD
                     ANYNRGTTGWHLNYNSTQSGDFNNPPASSGNKRNQLSSIINNGNRTICVYNDVVLAPDK
                     LLIKVPPYGDVPNLANIPGANDNADYWKINAC"
     misc_feature    complement(21877..21891)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.33"
                     /tool="antismash"
ORIGIN
        1 gccgggacga gcgggcccag gtagcgctcg atcggtccca ggtcgatgtg cgtcagcttg
       61 aaccaggccc gcgcgaacgc gtcctcgaac tcctccgggt tctcgaggaa ccgccgcgcg
      121 atcggcgcgt agatccggtc ctcctgcagc gcgaggtcgg tggtgagcat gaccggatgg
      181 tgtttcacgt ccgggtcgaa cggatccgga acggtgccct cgccctgtcc gtcgctgggg
      241 atccactgcc acaggcccgc cgggctgagc tcgacgtccc atcggtactg gaaaagggtc
      301 tcgaaaaagg tgtggtccca ggtgaccggg gtgcgcgtcc acatgccctc cagcccgctg
      361 gtcaccgcgt ccgcgccctt gccgcccagc cagccgagcc cctgcgcggc cagcggcgcg
      421 ccctcgggct cggggccgcc ggtcgcgttc gggtccgccg ggccgtgcgt cttgccgaag
      481 gtgtgcccgc cgccgatgag cgccacggtt tcctcgtcgt tgagccccat ccgcttgaaa
      541 gtctcgcgga tgtcgcgacc ggccagcacg gggtcgggat tggtggccgg gccctgcgga
      601 tcgacgtaga ccagccccat ttcctcggct gccaacggct cttcgagctc gtgcaggccg
      661 tggtggcgtt cgtcggccag ccacgtgcgt tccgggcccc agtacgtctc gtcgggctcc
      721 cacacatccg cgcggccgcc tgcgaacccg aatgtcctga agcccatgga ctccagcgcc
      781 cggttgcccg cgaaaaccat cagatccgcc caggagatct tgcggccgtg tttgcgtttc
      841 accggccaca ggagccggcg tgccttgtcc agattccggt tgtccggcca gctgttcaac
      901 ggagcgaagc gctgcattcc ggcaccggcc ccgccccggc cgtcgctgac gcgataggtt
      961 cccgcggcgt gccaggccat ccgcagcacc agcggcccgt aatggccgaa atcggcgggc
     1021 caccactcct gcgaggtcgt cagcacctcg tcgacgtccc gcgcgagttc gtcgagatcg
     1081 agcgtcgcga agtgccgcgc gtagtcgaaa tccgcgccca tcgggtcgct cgcgggaccg
     1141 ttccggtgca gcgccttgag gtcgagccgg tgcggccacc agtcgtcggg tttcccgccc
     1201 gccaccggag gattccgcct gccggaccgg ccggaaccgg ccaggaccct gtcataggtg
     1261 cggtagacgt gagtatcggg attgtcgggc atcgcggtcc tcccccgtcg ctcagtcgaa
     1321 ggccagcggc aacaggatcg ccgcgccgac gagcgagatg ccgctgagca gatccgcccg
     1381 gatccggatg accttggcgg ccatccggcc gacgaacagc ccggcgagcg acagcaccac
     1441 cgtcatcgcg ccgaaggtga acatcgggat caccaaagag aatccggcga tccccaggcc
     1501 ggccccggcg aggaagttgt cgacggtgag cgagaacggc agcccgaaga gcgtcaccca
     1561 cgggtggtcc aggtcgtccg cttccgtctc cgggttgcgg atcgccgaga cgaggaaata
     1621 caggccgtac aacccgagcg cggccacgcc gacgtactcg ccccagtcgc cgacgaattc
     1681 gccgaggtag cggccggcga ccccgcccag cagcgggccc agcgcgtccc agaggccgaa
     1741 aaccagggct acttgcaccg ctcggcgcca gccgaacgga atggttccga tcgcgatcga
     1801 cgagcggaag ttgtccaggc tgaggccgaa cgcgagcgcc accagcggaa gaaactcgag
     1861 attcacgggg accgcctctc cagggggatc gagcgcgctc ggagatgggc gcgaggtccc
     1921 gcgtccggaa cctcgcgccc atgcctattc gcggaacacg gccggtgcgg ccgggctgtc
     1981 agcgccggta gaagtagccg gtggcctcag cacacacctc gatgaccgtg tactccgggg
     2041 tttcccacat gatgtcgttc tccttctgct ggctgctccc gaaaaccgct cgatctcgag
     2101 gacaccgtca cgaaatctcc cggtcacgat ccagcttctt cgccttaaca cggcggcagc
     2161 aaccggcggt gcaccagcgg tcggcaaccg gtgccgaacg gtgcgccgcc gtcgacgagc
     2221 gggagcggcc gcgcacgccc cggcgacggc agcgacaccc tcgcaccggc ctataaggca
     2281 ttccaatgac tgtccggcaa aggtttcccg ccaatccgcc gagcacgaca ctagactcgc
     2341 cgccgtgcga atctatcttg gctctgatca cgccgggctc gaactcaaga accatttcgc
     2401 ggaacggctt tccggtctcg gctacgaagt gaccgacgtc ggccccgccg tctacgacgc
     2461 cgccgacgac tacccgccgt tctgcgtcga gacggcgcgg cgcgtcgtcg ccgacgaagg
     2521 cagcctcggc atcgtcatcg gcggttcggg caacggggaa cagatcgcgg ccaacaaagt
     2581 gcctggcgca cgcgcggcac tggcctggaa cgaggacacc gcacggctgg cacgccggca
     2641 caacaacgca ctgctggctg gcatcggcgc gcggatgcac accgtcgagg aggccgagcg
     2701 catcgtcgac gcgtttctca ccgccgaatt cgagggcgga cggcaccagc gccggatcga
     2761 cctgctggcg gagtacgaac gcaccggcga accgcccgcc ctgcccggaa aatgaccgct
     2821 ccgccgctgt ccggttccgg acagcggcgg agcggtcttc tcgctcagcc agcaagcaga
     2881 acgcgggcgc gctccctctc ggcggccgcg cacgcgtcac tgcggaccgg cgacgccaag
     2941 ctgctgttcg atccgctccc acaaccgcgc gtcgtcggag atcggccgtc cgtcggcgcg
     3001 agccgcccac gcaccggcga tgacggcctg gagcaaacgg ccgctgtcgc cgccgctggg
     3061 caggtcgggg acgccgtccg gcccgaggcc gtcgagacgc tctgccgagg cgctgtccag
     3121 cggcagcgcg gggacgagca gcccgctcac atcagcagcg acatacgtcg gacgggaacg
     3181 ccgcggtgcg aaagccagat cgcggagccg ggaggaaccg ctcagcacga aaagcgagtc
     3241 aaggccggcg gcgttcgccc cctcgatgtc ggtgcccagc aagtctccgc acaccaaggt
     3301 gtccggcgga gcagtgccca gccgagcgcg agccaagtcg aacaaggccg ccttcggctt
     3361 tccgaccacg tgcggggagg cgctggtcgc ggtctgcacc aaggcgacca gcgcgccgtt
     3421 gcccggtgcc ttcccgtacg gcgtggggag cgtgcggtcg atgttcgtgg cgacccaggc
     3481 agctccggct tccgccaggt agccgacagc cgcgagctcg cgccacgtga tgtcgtggcc
     3541 gagtccctgc acgaccgcct cgactggcgc gcccgccaag tccgcgacgc ggaccggcgt
     3601 caacccggct tcggccagcg catgggcaac gccagggccg ccgaccgcgc acactcgcgc
     3661 gcgaggagcc agccgctcgg ccagatacgc cgcggccgcc tgagaactgg tgaccaccga
     3721 ccagccggtc ccggcgaggc ccagctcacg caggtgatca gcgacgtccc cgggcggacg
     3781 ggacgcattg ttcgtcgcga agacgaccga cagtccgcgt tcggccgcct cgttcagggt
     3841 ctcgaccgcg tgcgggacag cggaagcccc gcggtacacc acgccgtcga ggtcacagat
     3901 cagcccgcgg tagcgcgcga gcagaggtcc ggcctcaccc acggccgcgc tccctgacat
     3961 accggtgttc ggactggatc gtccgcaccg tgtccggatc cgagcacagc acgagggacc
     4021 gcgtggtcgt gcagccctcg ccgtcgttcc ggacgccgcg cagcagttcg ctggtggtca
     4081 ccccggaggc acagaagacc acgctctcct tgcccaccag gtcctcggtg cgagtaaccg
     4141 cggccggctg ctgcgcggga ccttcgggca ccagccgcgc ctgcatcgat ccgccgaggc
     4201 aggacaacgc ggcggcagcg acgactcctt ccacggcgtt cccggtgcat aggaacacgt
     4261 cgatcggatg ctcaggccgc gccgcggcga cggcgcccgc gatctcgccg ccctccacca
     4321 agtggacccg cgcaccagcg tcctggattt ctcgggcgag ttccacgtgc cggcgtcgat
     4381 tgagcgtcgc gacgacgacg tccgacaccc gcaccccttt tgccacggca atcctccgca
     4441 agttctccgc caccgggcgg gtgatgtcga cgacgtccgc gaggccgggg ccgaccgcca
     4501 gcttctctat gctgtgctgc ggagccaggt cggccatcgc gccgcgcgcg ctgaccgcca
     4561 ccgcggtcag cgcgcggggc acatccctgg cctccgacag ggcgccatcg ccgatgctga
     4621 tcgcgatatc gcataccggg ccgtcgccgg cgcccacctc cgcgccgtgg aacagggcgg
     4681 gtgaatcgtc ttgcgtgccc accccgagca ccacgacgcc gtccatcgcc accgagcgca
     4741 gcgacgtgtg catcgcgtct atggcggcca gcctggcgct gtcgtcgctg tgcccggccc
     4801 atcgtccggc cgcgagcgcg gcggcctcgg tgccgcgcac gagttcgagg gcaagggcgt
     4861 cgtccgggcg gcgggcagtc tccgcggcgg cgaggcccca ttcctgactc ttcatagaca
     4921 tccatccctg tgcgcgaacg ggcaaatttc ctcgacccgg cccggccggt gcgagccgcg
     4981 gctcgcaccg gccgggtctt ctggtctggc ggtcagcgag ccgcggcgtt cgccaccgcc
     5041 cggtccgaca gcgccttctg agcggcttcc cgcttgctct cgtcgcctcg ccaggtctcc
     5101 agcgccggcc cgaccagcgc ccgtccgaac gagtaggtca gctcccacgg aagcgggccg
     5161 agcgtctgca tcgccgcgag gtgctcagtc gccttttccg ggctttgccc gccggacagg
     5221 aaagcgatgc ccggtacgaa cgacggcacc gtctcccgca gagcgtccac agtggccttc
     5281 gcgacctctt cgaccgacgg ctgctccggg cagtccttgc cggcgaccac catgttgggt
     5341 ttgaggacga tgccgtcgag ctgcacctgc atcaggctga gctcgtcgaa cagcgagcgc
     5401 aggacggacg tcgtcacctg cttgcacttc gccagcgagt gggaaccgtc catcagcacc
     5461 tcgggctcga cgatcggcac gatgccgcct tcctggcaca gaccggcata ccgtgccagc
     5521 gcgtgcacgt tggcccgcac cgcacggtcc gacggcaggc cgtcgccgat cgtgatcgtc
     5581 gcgcgccact tggcgaaggt cgccccgagc gccgcgtagt tcttcactcg atcgcgcagc
     5641 ccgtcgagcc cttcggtcac gttctcgccc ggtgcgcccg ccagcggctt cgccccggtg
     5701 tcgaccttga tcccggcgag gatgccgcgg tcggcgagaa actgcgggaa cgtctggccg
     5761 ttcgacagct tctggtgaaa cgtctcgtcg gcgaggatga tgccgctgac cgattccggg
     5821 agcttcgggg tcgtgacgat cagctcccgg tacacgcgcc ggttctcctc ggtcgcttcg
     5881 acgcccaccc cttcgagccg ggaggacatc gtcccgatgc tctcgtccgc ggcgaggatt
     5941 ccgcgccggt cggagaccat gatgcgagcg atcttgttaa gagtggacat cggtagttac
     6001 tcctcctgtg ctagtgactt tcgggccagg ctgcgggcct ggcatgggac tgcccttcgc
     6061 cgccgcgatc tcgaccagct ccttcgcgtg tccgggcaat ccccggcgtt cgctccacgc
     6121 cgcgtaaatc ggcttcgccg gcatctcctg ttcgaccggg accagccgca gcctgccgtc
     6181 cgcgatttcg gagcggacgg tggagatgtt cagcacggtc acccgcctgc ccgcggcgac
     6241 cacctgcttg accgccgcgc tggagggcag ttcgacgtag cttcgcgaag cacgcgcgga
     6301 acccagcagt tcgtcggtga actcccggag cccggatccc cgctcgcgca ccaccagctg
     6361 ggccgaggcg agctcctcca ccgtcaccgg accgggccgc ttcgcccacg gatgcaccgc
     6421 cccgacgacc accgccagct tgtcgtcgca gatgtaccgg gtgaccaggc cttcccggaa
     6481 ctgtttcggc agctggcttc cggcctggca ccagccgtcg atgaacgcga cgtcggcctg
     6541 gtccgcccgg atcagctgcc gcagctcgtc gacgcggccg gtccgcacct ccacccgcac
     6601 ctcgccgaac gagagcccgg accggttcag ccattccggg atcaggtgct cggacacgcc
     6661 cgggctgccc gcgacccgca accggctcgc gctggacgaa ccggagccga actccagtag
     6721 ctcccgcgcc gcgtgcatca cgttgcgggc gtacttcgcg agcatttccc cttcctcggt
     6781 cagcttcgac ccggtcgggg aacgttcgag cagccgcagg ccgagccttc gttccatggc
     6841 actgatccgg atgctggccg cgggctggga aaggctgtgc gcctgcgccg ccttccccac
     6901 gctgccgtag cgttcgacgg acagcagcag atcgaggtcg gcgagctgag gcatttttga
     6961 gggaagaacc acgatttccc cctctcgctc cggaatacgt cgtactgtgc ctgaggaagc
     7021 aacactgacg gtgcgcggac tgcgcgaccc gcggtcacgg gacccgcggt gtgcactgag
     7081 cctgcactgg ccggtgagcc tggtcaatcc gagggacacg aacgtagccg ctgcgaagac
     7141 gaacggtgca cagtacgtca cctgcggggt ttccggcctg cccctatggc cgttgagcag
     7201 cgaaacacct tggcaggtaa gggtttcatc ccgctcagca ccaaaaaacc gccgtctgtc
     7261 actatttccc gcccgtccga cccagaccgg tggccgcact tgcaccgcgt cgcagatgct
     7321 tcccggcgaa gcactcgccc ggaatccttc aacaggagga aataacgtga agtgggaaac
     7381 gccgaagtac acggtcgtcg aggtttgcgc tgaagccact ggttacttct accgaggctg
     7441 acagccactt cagccggcgc aaggcttcag tctgcccacg cgactgaagc cttgcgcctt
     7501 ccattcacct cgttcgatgc gccgcgtcgc acgctcgcgc cgcacgcatg atcagcagtt
     7561 cggtgcgctc ctcgcggaga accttcacca cgttccgcgg caacagcgtg ctttccagca
     7621 agcgcccggt gcccgccagc acactctgct ccgcagtggt gaaatgagga tagagcgcgc
     7681 gggcgaaggc caccgcgaat tccggttcga cggtgcccgg catgctttcc aacgtcctca
     7741 agtagcggtc cgcatacggt gtgagcagtc cctcttgccc gggttgcggc aggcccgcca
     7801 tgacggcttt ccgctcggcg agcgaaaatt cgccgttgaa cagccgctcc cagcccgttt
     7861 ccttggctgc cgccgcgggc cgggcggcct ccgcggtcaa ggcgttccgg cggccgctgt
     7921 caccgggatc cgcctccacc gcgacatcca ggcagccgtc gaggtcgtgt cccgtcgacg
     7981 cgaggcggaa caccgcacgc cagcgcagat cccgatccac ttccaggccc gcccacgggg
     8041 atcgcccgta cgcgatttcg ctcagcagac ggtgttcccc gtccgggacg acgccgacca
     8101 gggcgcgggc gaagaccagt tggcgatcgc tgcccgcagc ttcggcggcc agcagtgttc
     8161 gcacctggtg cgccagcgtc gccagcatct ccgtacggcg ggacggatcc ccgtaaacgc
     8221 ggacagcccg cactgcgcga tccagcagcg cttccagcac cccggcatcg ctctcccctg
     8281 gcccgtgcgc gagaacggca gcggcgtagc tccgcgccgg caagcgcgcg tcgagcacct
     8341 cgtcccacaa cgctccccag acgactgccc gcacccgctg atcgtccact gcggacaaac
     8401 tcgccagcgc cttctgccgg gaccgggcgt ccagccggat cttgacgtgg ctcaccgcgt
     8461 cgtcgttggg caccaccaga tccgcgtcgc cgaagccggc cagctcgcac tcgcccgaat
     8521 caagcgaaac gtgcgcgcgc cggcgcagca ccatctcgcc ctcgcggtcg tcgaacgcgg
     8581 cgacccggag gttcagcctc cgcggcggaa cgtccgcgtg ctggacaagc aggtcccgga
     8641 ccatttcgac ggtattgacg ccgctgctca gcagccattc ctcgacccac cggccgacat
     8701 cttcgcctga agcccgctgc agcgcggccg cgaagtcgcc gagatcggcg ttgccccacg
     8761 cgtgcgtccg cagatagatc cggacccccg cgacgaacga gtcccagccc agccgctccg
     8821 ccagctcacg caggactgcg gcgcctttcc ggtacacgat cgggccgaag ttcgagcgcg
     8881 ccgcgtcggt gtcgggcgtc gcgacccgga tcgcgtggct cgtcggcaac tggtcggcgt
     8941 gccgggcgag gggcaggttg tgatgcgcga agccggtcca gccttcgccg taccgcgtcg
     9001 cttcaggctg cgcgacgacc gacatcatgg tcgcgaacgc ctcgttcagc cacagatcgt
     9061 cccaccagcg catggtcacg taatcgccga accacatgtg cgccatctcg tgcgtcagga
     9121 gttcggctcg ccttcgccgc gtgtcctcgg tgacccggtg ccggaacaga aaccgctcgt
     9181 tgagcgtgac acagcccggg tgctccatgc cgccgaacgc gtactcgggg gcgaaaacgt
     9241 ggtcgtattt ggcgaacggg tacggcaggt cgaacaaccg gcggtagaag tcgagcccgc
     9301 gacggaccac gtcgaagagc tcgggagcct ggcgggtcaa tgcgcagtaa agggagttcc
     9361 gcgcgtagag gcccagcggc agtccgtcgt gcaaggcttg gacgcggcgg aacgggccgg
     9421 cggcgaaggc caccaggtag gtcggcagcg gcggggtggg cccgaaacgc cagctggtgc
     9481 ggtcgccctc cagcggcacc agcttttccg ggtcggtgtt ggcgaccacc gtccagtgat
     9541 cctccgcggt cacggtcacg ccgaccgccg ctttcagatc cggctggtcg aaacaggcga
     9601 agacggtgtg cgccgcgaaa ggctcgaact tggtgtgcag gtagacctgc ccgtcgagcg
     9661 ggtcgcggaa acggtgcaag ccctcgccgg tgcgcgaata cggagcggtc ccggccacgc
     9721 gcaccgtgtt ctcccccggc ctcgcgatca gccggatgcg ggcgccggcc tgtgctgccg
     9781 gccccagttc acggtcattg cactccaccg acgcggctgt tcccgcaaag tcgagaaaga
     9841 gctcgccagg ctccgcgcgg aagcgcacga cggtggtcgt cgcgaactcg tcctcgcctg
     9901 tcgtcaggtc gagttccacc tcgtaccgga cgtgcgagac cgccgcggac cgcgccgacg
     9961 cctcttcttc cgtgagtttc gtgcctgcca gcgacatccg tcagtgcctc cgcgcggccg
    10021 gacgccggta aaccaggtcc gccgcttcgc cgttgctgtg attggcccgg accagagcgt
    10081 cctggaccag gtgatggtcc ggcgagtgct ggcacaccgg atcggtgcgc gccgcgtcgc
    10141 cggtcaacgc gaacgcctgg cagcggcagc cgccgaagtc gatctccttg cgcggacagc
    10201 tctggcatgg atccggcatc cacgccgttc cccggaaggc ctggaacgcc tcggatttcg
    10261 tccagatcca ctccaggtcg tggtcgcgga ccgaggagaa ggccatcgtg gtgatctcgg
    10321 cggccaccgg acacgggtac acggtgccgt ccggtgcgac ggtcagcgcg ttctgcgccc
    10381 atccgcccat gcacggcttc gggtagggct cgtagtagtc cgggagaatc cagaggagtt
    10441 ccatccgctc ccccagttcg gccttccgtc gctcgtacac ggcgaccgcg tcgtccagct
    10501 gggccttgct cggcatcagc cgctcgcggt tgcgcagcgc ccagccgtag tactggctgt
    10561 tggccagttc cagccgctcg gctccccatt ccgcgcagac gtcgatgatc gcgtcgagcc
    10621 ggtcgaggtt cagccggtgc agcaccacgt tcatgttcaa cggcaggccg gcatcgcgga
    10681 tgatgcgcgc ggcggcctcc ttcttgtcga accgcttgct ggccgcgacc aggttcgtcg
    10741 attcggcggc gtcgccctga atgctcaact gggcgctgtt gagcccggcc gcgaccagag
    10801 cttccgcccg gccctccgtc agcccgaggc cgctggtgat caggttcgtg tacagcccga
    10861 gaccgcggca ttcggcgacc agggtctcca gatcgccgcg caccagcggt tcgccgccgg
    10921 aaaagtgcac ctgcacgaca ccgagcccgg cggcctcgcg gatcacccgc aaccagtcct
    10981 cggtggccag ttcctcctgc cggtcgagca ggttcagcgg gttcgagcag tagacgcaat
    11041 gcagcgggca ctgatgcgtg acctcggcga gcaggccgta gggctgcggc aagccggtca
    11101 tgcgaccacc acccagcccc ggcctcgcgc gtcgtgcagg aatttcatca cgtcgttcgc
    11161 gagatcggcg gcctggaaat cgcgttcgag ctggtcgacc acctgccgca cggtccggct
    11221 gccgtcgcac agtcccagta tcgccgcccc ggacttgttc agcagcacca cgcgttcggg
    11281 caacaggagc aattcgacgt cccggacgtt gtcgtgcttg agcatcgctt tcgtcgccag
    11341 cttcggcacg gcggccaatt cggactcgtt catcacgaac tcttgcggta ggcgagttcc
    11401 acggcgtcca gcaggctcca gagcacgtcg cacttgaact ccagcgcacg ggcgcacgct
    11461 tcctgctgct gttcggtctt cgcgttctcg accaccaatt cgagcaggtg cgcgatgtcc
    11521 ttgggctgct gagtgagccg ggcccggaag tactccaggc cctccgccgc gatccacggg
    11581 taatggcgct ggacatcggt gatccgcctg ctgagcaggt ccggcgcgaa cagttccgtc
    11641 aacgccgacg cgaccgcctc cagccacggc ttctgacggc agaagtcaac gtacgcgtcg
    11701 accgcgaacc gcacgccggg cagaacggtg tccacgtcgt acagttcctc gcggctcaag
    11761 ccgactgctt tccccaagcg gacccacttt tcgaggccgc cttcgccgcc ggtgcggcca
    11821 tcgtggtcgg tgatccgcgt gatccacctg cgccggtcgt cccggcccgg gagcttggtc
    11881 aggatgaacg cgtccttttt cgggagattc atctgatagt agaagcggtt ccgcacccat
    11941 ccgcgaaatt ccgcctcgga cagctctcca gcgtgcatcc gctcgttgaa cgggtgcaga
    12001 tggtggtacc gcttctctcc gatggaccgc aggtacgctt cgaactcctc ggcagacctg
    12061 acgctcatac ttccacctcc aagccggctc ggccgatttc gatgcccaag tccgtcaccc
    12121 agcgccgttc tggggactct tcgtcgagaa tcggattcgt gttgttgatg tgcgtgtaga
    12181 tctttcgctt cgcgggcagc gcggcgagcg cgcgagccga tccgccgtcc ccgctgaccg
    12241 gcaggtgccc catcgaccgg ccggtccggt ttcccgcgcc ggtcgcggac atttcgtcgt
    12301 ccgtccagaa cgtcccgtcc acgaagacgc agtcggccga tgccacctgc tgctcgaact
    12361 tctcgtccca tcgcggcacc gtcggcgcgt agaccgcgat cccgccggtc agcttgtctt
    12421 ccaggcgata gccgacctcc cattccgccg gctgttcgcg gagctgggaa ttccccacgt
    12481 agcggggagc cttggaaccg gtcaggaacg cggtcgcccg cacccggtcg tccagatcga
    12541 ccggctcgcc cgcccggacc tcggaccagg agatgtcggc gtagtcgctc agcagctccc
    12601 gcaccgggaa ccagaggttc agcgcctcca gcacgggaaa ggtcccgtgc accgtcagcg
    12661 acgattcctc gcgcagcatc agcaggccga tggtgtggtc gaattccgcg tcggtcagca
    12721 cgaccccggc gaccggcgtc tcccggatgc ccggaccggg atgcagcacg ggatccgccg
    12781 cgatctggtg gagaacgtcg ggagtcgcgt tgaacaggaa ccaccgctcg ccatcgccgg
    12841 aaaccgcgat cccggcgtgc gccgtcgcgt gctccggctt agcgcgggcc ttgacgcacc
    12901 cggcgcaagc gcaattccac tgcggatagc cgccgcccgc ggcggccccg aggcaatgaa
    12961 tcaacatccg tcaacgccga ccacgaggcg cggaaagaac ttcggccacc atggattccg
    13021 gcatttcgcg cctcataacg tcctcccgca ctgtcgaccg gcggcaacgg caggacaaac
    13081 aggcgccgtt gcccgccgag ggctcagccg gcgcgattat ccggtatcgt cgccctgaac
    13141 tcggctattc tccggaaagc ttcttcgctc gcatcggggc ctggcaaccg ctcgcgcacg
    13201 accggagccg aatcacggac gaacggcggc cgcgccgaga cgagcgggaa gccgtgcgca
    13261 ctagtgccga cgagagccgg gaagcggccg tgaccagcag atcgtcgatg cttcccgcac
    13321 cagccggccg aggtctgccg ggtcgcgaag gcccggaccg ccgcgccccg gcggccggcg
    13381 gttattgatt gtgcctatcg ggggattgtt tttcctcatg cggcgaagca ttgccgggcg
    13441 caggcggcgg ggtgatggtg ggtgacctgt cgcgttttcc ctttctaccg tgaggagttt
    13501 gttgtgcggt tgcaggttgc gttggatgtg ctggatgtgg gttcggcgtt ggcgttggcg
    13561 cgtcaggtgg cgggggaggt ggacattctt gagctgggga cgccgttggt gaagtcggcg
    13621 gggatttcgg cggtgacggc ggtgaaggcg gcgcatccgg acaagctggt gttcgcggat
    13681 ttgaagacgg cggacgcggg ggagctggag gcgacgctgg cgttcgaggc gggtgcggat
    13741 ctggtgacgg tgatgggggc ggcggacgac gacacggtgc ggggcgcggt ggcggcgggc
    13801 aggaagtacg gcaaggaggt ggtggcggac atgatctcgg tgaccgaggg ccgggtggcg
    13861 cggatccggg aggtggcgaa gctgggggtg tcgttcgtgg agatccatgc cggtctggac
    13921 gagcaggcgc gtccggggta ttcgatcgac acgctgctgg ccgacgggcg cgaggcgggg
    13981 gtggcgttct cgatcgcggg cggggtgaag gccgcgacga tcgggctggt gaaggacgcg
    14041 ggcgcggccg tggcggtggt cgggggcggg atctacaacg cgcccgaccc cgctgccgcg
    14101 gcccgcgaac tccgccgcct caccgcctga ccccacccgc ccgatcggaa cagaagggag
    14161 tcggcgtgga agtccagaac ccagccgcgg gcagcactta cggctcgttg ctcctgcagg
    14221 ccgccggagt gctgcggctg cgctacgtgg aatgccggcg ggacaccagc ttgtccccgg
    14281 aggcggcggc cgaactcgcg accgtcttcg aggcgctcgc ccaaggcgag cccgcgttcg
    14341 accagatcga cccgaaagaa gcgatcgcct tggcgaaccg gctgatcgac gacgaccatc
    14401 cggagctttc ccacctgtgg cccacgaccc ggtaacccgt ccacggatca ttcgcaactc
    14461 aacgaggagt acacgatgac gactgccgaa gccaccgaag cgcccgcacg caccattccc
    14521 gagggggatc ccgctctgat cggcgttccg accttcatcg tcggcgccac cgcgctcggc
    14581 ctggtgctga ccggctacgt cccggccggc gccgtcgggg cctcgatcgc gatcatcctg
    14641 cccgccaccg gcctcggcca gctcgtcgcc gcggtatggg ccgccgcaca gggccagagc
    14701 gccgtcgcct ccgtgttcgg catcttcgcc gggttctggc tcagctacgc ggtgctggtg
    14761 ctcggcctga cccacaactg gttcggcatc cccgccgacg ccgcggtgtc cacccaaggg
    14821 ctgttcctga ccgcctggct ggtcatgatc gtcctgctga cactggccag cctgcggctg
    14881 cccgccgcgt tcacccttct cttcgcactg atcgacctcg cgctcgcact cgtgctgttc
    14941 ggcaccgtga acggctccgc gggcctcacc actgtgggcg gatacgtcgt gttcgcgttc
    15001 accgcggtcg gggtgtatct cttcctcggc gcgatgtccg cggcgacggg cggccgctcg
    15061 ctgccgctgg gccggccagt actgagctga cccggaacgg ggcggccgcc cggccgcccc
    15121 gttttcgcgt gtaccgcaaa ggagttgatc tgtgacctcg ccgaccttcg tcgtcatcgg
    15181 agccggactg gctggggcaa aaggggcgga agcgttacgg gacaagggtt tcgacgggcg
    15241 gatagtcttg atcggagacg aggagcacct gccctacgag cggccggcgc tgtcgaagga
    15301 ctatctgtcc ggcaacgcct cccgcgacag cctgtacgtc cacgacgcga cctggtacgc
    15361 cgagcagcgc atcgagctgc gcccgggtgt ccgcgcgacc ggcatcgacc gggcggcgca
    15421 cgaggtgcgg ctttccgacg gcaccagcct cagctacgcg aaactgcttc tggccaccgg
    15481 tgccagcgca cgcacgctcc ccggtgccac cggggtccgc tacctgcgcc gtcttgaaga
    15541 ttccgattgg ctcaaaggcc tgttcaccac cgccggcagc atggtcgtgc tcggcgccgg
    15601 ctggatcggg ctggagaccg cggccgctgc ccgccgagcc gggctcgacg tgaccgttgt
    15661 cgaagcgctc ccccagccgc tggtgcccgc gctcggccgc gaagtcgccg ctgttttcac
    15721 cgacctgcac ctgcagcacg gcgtcgatct gcatctcggc gtccaggtcg accaggtcga
    15781 gcgaggcaag cgcgtcaagc tcgccgacgg caccgtgctc gaggccgacg cagtcgtcgc
    15841 cgggatcggc gctcagccca acaccggcat cgcgcgcgcc tgcgggctgc gagccggcaa
    15901 cggcgtgctg gtagacgcga gcctgcgcac cagcgacccc gacatcttcg ccgccgggga
    15961 cgtggccaac gcctaccacc cgcagctgcg ccgccacgta cgggtggaac actgggcgaa
    16021 cgcgctcaac cagcccgcgg tcgcggccgc cggcatgctc ggcaagaacg acgtctacga
    16081 cgaactgccg tatttctaca ccgaccaata cgacctgggc atggaattcc tcggcacgat
    16141 cgacagctac gaccgcgtcg tgttccgcgg cgacgtgccc ggccgcgagt tcatcgcctt
    16201 ctggctcaag gacgaccggg tcctcgccgg gatgaacgtc aacgtctggg aagtcactga
    16261 gccgatcaag gcgctcgtcc gctcccgccg cccgatcgac ccggacctcc tcgccgaccc
    16321 cgacgttccg ctcgaccgcc tcgcggcccc ctgaccacgc gatggccggg ttccgtccac
    16381 cgtggacgga acccggcctt ccgctgtcct caatgcccgc gggcgatcca ttccgacaag
    16441 tgcggcgcct cgtcgccgat cgtcgtggcg tcgccgtgtc cggtgtggac cttcgtggcg
    16501 gcgggcagtt cgagcagcct gtcgcggatc gacgagacga tcgtcggaaa gtccgaaaag
    16561 gaccgtccgg tcgcgcccgg cccgccggag aacaaggtgt caccggagaa caacgcgcct
    16621 gcctcgggca agtacaggca caccgagccg ggcgaatgcc ccggagtgtg gacgacccgc
    16681 agctccgtgc ccgcgaccgc gatccgttct ccgtcctgca ccggccagaa tttccggtcc
    16741 ggatgagtca tctcccacag ctcctggtcg ccggggtgca gcagcaccgg cgcgtggagg
    16801 ttcgcggcca gcgccggtgc gacggtgacg tggtcgttgt gcccgtgcgt gcacaccacg
    16861 gcgacgacgt tccggccgtc gaccgcgtcg gtgatcgctt tctcgtcgtg ggcggcgtcc
    16921 acgatcacaa cctcttcgtc ccctccgacc agccagatgt tgttgtccac cgcccagctt
    16981 ccgccgtcga gctcgaaaac gccggaagtg acgacacgct cgatgcgcag gccgctcacc
    17041 agaccaccac cgagcgcagc acgtcgccgg cgtgcatcgc gtggaaggcc ttctcgacgt
    17101 cagcgagccc gatgcgttcg gagacgaact tctcgagcgg aagccggccc tgccgataca
    17161 aatcgatcag catcgggaag tcgcgctcgg gcaggcagtc gccgtaccag gacgacttca
    17221 gcgccccgcc gcgggaaaag aagtcgatca gcggcatctc cagccgcagg tccggcgtgg
    17281 gcacgccgac cagcacgacc gtgccggcga ggtcgcgggc gtaaaacgct tgctgccacg
    17341 tctccggacg gccgaccgcg tcgatgacga cgtccgcgcc gaacccaccg gtgagttccc
    17401 gcaccgccgc gaccgtgtcg gtttcggacg cgttgacggc gtgcgtggcg ccgagatcgc
    17461 gtgcccattc gagcttccgc tcgtcccggt ccaccgcgat gatcgtggtc gctcccgcga
    17521 gccgggatcc cgcgatcgcc gcgtccccga ctcccccgca gccgatcacc gcgaccgagt
    17581 cgccgcggcc gacggcgccg gtgttcaccg cggcaccgag gcccgccatg accccgcagc
    17641 ccagcagacc cgccacggcc gggtccgcgg acgagtcaac cttggtgcac tgtcccgcgt
    17701 gcacgagcgt cttgtcggcg aacgcgccga tgcccagcgc gggggtcagc tcggtgccgt
    17761 cggcgagcgt catccgctgg gccgcgttga acgtgtcgaa gcaatactgc gggcggccgc
    17821 gcttgcaggc ccggcactgg ccgcagaccg cgcgccagtt caggacgacg aaatcgcctg
    17881 gccgcacgga gtcgaccccg gcgccgacgc tttccaccgt gcccgccgcc tcgtgcccga
    17941 gcaggaacgg gaactcgtcg ttgatcccgc cttcgcgata ggtcaggtcg gtatggcaga
    18001 ccccgcaggc cgccaccgcg acgaccacct cgcccggccc cggatccggg atcacgatgt
    18061 ccgtcagttc caccggactt ccctgcgaac gggcgatcac cccgcgtacc tgctgtggca
    18121 ttctttcttc cttcgtgccg agcgacaaac catgtgccag agcgcatgcc gatcccgacg
    18181 ctagtggcgc gccggcccgc cgcgacccgg tcgtccggcg aggaattcct ggtctttcgg
    18241 ctaggcaccc gacgggttat cctgagccgg atgcctgccg acccccgcgc cgccgtcgac
    18301 ctgccggggc tgcgcgacgt cgtggacggc ccgctgcacg acatcgccgg ccgcttctcc
    18361 cgcttcctcg ccgagacctg gccgcactgc gccctcgtca ttttcaccaa ggagtgcacc
    18421 ggtcggcccc gcaaggtcgc cggcgacgcg gagacgacgg acaagatcgc gatcgccgaa
    18481 ctcgaagcgc tgaaggcggc cgtgcatccc ggccgcgcga cgagcacgac cgcgcagctc
    18541 ggcggtgcgg cccggccggt gtgggccgtg cacgacccca tcggcacgct gctggtcctg
    18601 atcccccgga ccgtgcggaa accagtcccg cgtccggtgc cgctcgccga actgttcggc
    18661 atcgtcgcga catccatccg gcagcaagtc acgcaagcga gccccgatta cctcaccgag
    18721 tcccgggcgg cgtcgagcga acgcgcgcgc acgatcgtcg aaatggccgc aacccaggaa
    18781 agaaccctcg tcacggtcct gaacgcgctg cggtcgacca agctggacgc cgagggtgcc
    18841 cgagccgccg ccaccgacgc cgcctcagcc gcgctggtgg ctctgcggtc agcccacaag
    18901 accgatctcg cgctgtccga agagccggtg cacaccgcct tcgcccggct gcgccgggaa
    18961 gtacggcagg ttctgcgcca ccacgacgcc gaactggagt tcgtggagcc gcagcccgac
    19021 acgcgtccgc tgtgcggaga gctcgcgccc gccgcgcgag ccatgacctg cacagcggtc
    19081 ctggcgttca ccgcacagcc gacgttgacc cggctgcgcg tcgcgtggtc ctgcgacgat
    19141 tcttcgctgc ggctggacat ccgcgaccac gagtccggac gcctcgacgt cgacgcgctg
    19201 cacctccagc tcgacggacg cgcgaaggca ctcggcggca gcgtcgaggt cgacgcggtg
    19261 tcgggctggg gaagccgggt ctcgatcgtc ctcccccgct ctgtcgcccg ggacagcacg
    19321 gacacgacca gcctctcgaa actcaaccgc cgagagctgg aagtcctgcg acacgttgcg
    19381 cacggcttgc ggaacaaggc gatcgccgag cggctcggca tcacggagag caccgtgaag
    19441 ttccacgtcg ctaatgtctt gaagaagctg aagacaggat cccgagggga agctgcggtc
    19501 ctggcgttga atgccggggt cgcatgactg cgtcgtcgta tgggtgccga aaaccgtgtc
    19561 acatcacgcg acctgctgat attcgtagat cagaccgcca aggcgaccgt gccgacgtac
    19621 caatccggca tcacgcatcc ggaccggaac ctgccgttcg ggcggtcgtc ggcccaagga
    19681 gcgatgagga cgacggtgat tgacgtactc ggccaggacc tgttcgagat gaggccggtt
    19741 gacgataaac agccgatcca gacactcgcg gcgaccgctg cccacccagc cttcagcgat
    19801 cgcgttcgcc cgcggcaccc gaacaagact gcgcaggacg tcgatgccga ccgaggcgaa
    19861 taccgcatcg aacgcggccg tgaacttcgc gtcgcggtca cggatcagaa accacaaact
    19921 gtccactcgg tcgccgagtt caaccagcag gttccgggcc tgctacacca gccactccgc
    19981 agtcggacga gccggcgcag caacaccgtc tctacgtgaa agaaatccat cgccagaatg
    20041 ccgctggcct ggacagtgag gaactgcttc cacgtcggtc ccgatcggcg cggtggcggg
    20101 tccactcccc catccttgag gatcttccac attgtcgacg gcgcaatcgt gtatcccagc
    20161 ccgacgagtt cgccgtggat tcggcggtaa ccccaacccg gatcgtccct cgccatctcc
    20221 cccaccaacc ggcggatcac cacggcaaca gccggccgac ccggtcgact cccgtaggtc
    20281 caccgacgtc gcaccaatgc cgtcaatacc gcacgatcag cccaggtcaa acgcggtcgc
    20341 gacgcctgac gctgaagcac cgcgagctga tgacgcaaca ccaaaatctc cgcatccttc
    20401 gcagcattcg accgcgagca cagcaccagc caaccgaaca cccgcgtcac cagcagatac
    20461 agaaacctca tgaccacaag tcgtgatcat cgaccaccaa gcagccaccc catcaaccac
    20521 ccgcccacac gccgcaacca gctggtcggc actcataaca acgttgccgg cagccacagg
    20581 gcctcgtcag cagacaccgc gcggttccga acctccgcgg agacgcgatt tcatcgggct
    20641 gacctgcggg aggacggcgc gaggacgaga cggggacggt tcccggcagc gttgtactcg
    20701 tccggccgcc cgctccggtg gcggccgctt cgaggggaga aacccgcatg cccacgatcc
    20761 gctccgcagt ggctctcgcg gccgccgtgg ccggtgccgc cgccggcacc gtccttgccg
    20821 cggccccggc ctccgccgcc accgcaccgt gtccggccgg ttactactgc ttctaccagg
    20881 acgccaacta caaccgcggc accaccggtt ggcatctcaa ctacaacagc acgcagtccg
    20941 gggacttcaa caacccgccc gcgtccagcg gaaacaagcg caaccagctg tcgtcgatca
    21001 tcaacaacgg caaccgcacc atctgcgtct acaacgacgt cgtgctcgcg cccgacaagc
    21061 tgctcatcaa ggtccccccg tacggggacg tgccgaacct ggccaacatc cccggcgcca
    21121 acgacaacgc cgactactgg aagatcaacg cctgctgatg aaagacgcgg gagcccttgc
    21181 cgagcagggg ctcccgcgtc tttcatcagc gactttccgc cgcaccgggc caaagcaccg
    21241 attcggtgcc gaatcggtcc gcaagctcct gcgagacagc ctgacaccga taacgcaacg
    21301 gcaccgccag gacgggatcc agcggttcgt ccgaggacaa gactctggcc accctgagaa
    21361 actgcgacgc agcggcgaca tcgtgcacac aggctaccgc cccggcagcc cggccagctg
    21421 tgcaagtgcc gccaaagttc ccggcacccg ttcagcgggc ggcgacggcg acagcgctcc
    21481 gatgaagtcc tttcgggaga tcgcgatcag cagcgggagc ttgaagctgg tcagtgtccg
    21541 caatccgcga agcatctcga tcgactgcgg cggcgtcttc gccaggtcga tccccggatc
    21601 caaccacacc cactcgaccg gcaggcccgg tgcggcgatt tcccccagtt tgccttcgca
    21661 accatgcgct cgcctcgtcg acgacatgcg tgtagccgcg gggtccaaga ctttgttcct
    21721 gaccccggca gggttgtgtg tcaagacaag gtcggcatcg cgaagccggc ccgccgcgag
    21781 atcgaacgcg cgaagcggcg tgtacccgcg ccaaccgccg acaagcacca cggtcgctga
    21841 aacgaccaga tgccccggga atatcgggaa cgtcagcgga ccagatcggc cgcccggtcg
    21901 cgaggtccaa acaggacagt cgagatcggt cctgcgggac agcagacaac gaccgccgcc
    21961 gatggcaacc gcacgcggcc acgtatcgac cggagcatcc caccgcaccg aaccatccgc
    22021 cggatcaaga ctcaccaatc tcgtgctgcg ctcgtgaacg acgacatg
//
