LOCUS       NZ_CP091381            24445 bp    DNA     circular CON 18-AUG-2024
DEFINITION  Amycolatopsis sp. FU40 chromosome, complete genome.
ACCESSION   NZ_CP091381
VERSION     NZ_CP091381.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. FU40
  ORGANISM  Amycolatopsis sp. FU40
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 9944196)
  AUTHORS   Reisman,B.J. and Bachmann,B.O.
  TITLE     Biosynthesis of Apoptolidin Family Glycomacrolides
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9944196)
  AUTHORS   Reisman,B.J. and Bachmann,B.O.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-2022) Chemistry, Vanderbilt University, 1234
            Stevenson Center Drive; Room 7330, Nashville, TN 37235, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 23-JAN-2022
            Assembly Method                   :: Flye v. 2.9
            Assembly Name                     :: NFU40_flye_2.9
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 47.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_021903635.1-RS_2024_08_18
            Annotation Date                   :: 08/18/2024 04:30:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,491
            CDSs (total)                      :: 9,417
            Genes (coding)                    :: 9,360
            CDSs (with protein)               :: 9,360
            Genes (RNA)                       :: 74
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 7 of 57
            Pseudo Genes (incomplete)         :: 50 of 57
            Pseudo Genes (internal stop)      :: 5 of 57
            Pseudo Genes (multiple problems)  :: 5 of 57
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:13:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5111386
            Orig. end                         :: 5135831
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP091381.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Brian O. Bachmann,
            Vanderbilt University.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24445
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="23"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24445
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24445
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14445](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14445
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(291..306)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.02"
                     /tool="antismash"
     misc_feature    717..731
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.74"
                     /tool="antismash"
     misc_feature    722..736
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.59"
                     /tool="antismash"
     misc_feature    complement(857..869)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 18.09"
                     /tool="antismash"
     misc_feature    1014..1029
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.7"
                     /tool="antismash"
     misc_feature    complement(1891..1911)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.02"
                     /tool="antismash"
     gene            complement(2153..4729)
                     /locus_tag="L3Q65_RS24350"
                     /old_locus_tag="L3Q65_24345"
     CDS             complement(2153..4729)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="L3Q65_RS24350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="L3Q65_24345"
                     /product="hypothetical protein"
                     /protein_id="WP_237596719.1"
                     /transl_table=11
                     /translation="MPLIAADGHSAGLLNAIRYTLLSSAPLVIAWFRLRRPRRTRTRAG
                     SPASSAQPSLRQRSAVDTLGSRTAAIVRALLVLHVVVGVGLIVSLASSYLTEKLFSLPD
                     AALDSVMARPGAVVPAATVIASAFVWRRFTLRSVTVSTDRRSSIAKDVGWIVVASAAVL
                     VPTGLMWPGASTQATTGTGRSFWATWLAVLLVVIWMLQVAALVGFLVAKLAGATPKTQG
                     RIAWIAALLTGAGFLVLIGQATLWSPWDDPDAPRTLAAWLSTEPGVLAMVFVGLGFLAL
                     LVAFLALVRRPNPRIGGTGRPLWWSVLAIVVEWFVAAALLMLMAGLLDLVVRNGWLWWA
                     AEPGWSEWYSGRSGHLVALYLAMLVAAFGINILGRALRLRPRDRLTMVAGVTLTALLLL
                     IEPVTARQGFLGTAVGAAVPLTAAVFVWLTLDRVARHALEAAPPSVWLGRWPFLRRWRG
                     VRVVVALLLSVPLVVYGGAGVPPMTWYDFGTFASSVDGALPLFVFGFLLLLMRHLGSAT
                     GDGAIRGTPRLIRAVAVLLTVVGILSPSATTPGLPVAFFIGWALVEVWLLPRPADDAER
                     AAAGDAVDASGTAAVRAVVRDAATARTEAALEKELRQKLAEDAPDEDTQNRRLERITEL
                     ALGEHRLSPERRRLAFSSYGGGTAWRNARQFAGLGFVIGLPWTVLDVAAAISTLTGDGP
                     YRLVDTAAGILVILRFAIAGLIVGGAYPLVRGTTGLAKGFSLFIAMSGPALCLTLLPDP
                     RAHDALASATLQLAQWLSFGLILGLMADWQVLRCHGYGLRHLRELHRMNALTASASTLL
                     LAVLTAAATALGSGAAGALVERVLTPPPAATAPSSPANQGTSSGGR"
     gene            complement(4742..5461)
                     /locus_tag="L3Q65_RS24355"
                     /old_locus_tag="L3Q65_24350"
     CDS             complement(4742..5461)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="L3Q65_RS24355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="L3Q65_24350"
                     /product="hypothetical protein"
                     /protein_id="WP_237596720.1"
                     /transl_table=11
                     /translation="MRVVARALLGVLGLLLAIVALTYVSGVLRQESSPAEQLVKDAPEP
                     WVTNTTVTSPDLEDALRRSPAKSLSVAATLTVVAPGSSGDVPRAKLSLSITGPTSNPLL
                     ELVRQGHARGRGLALAWSVGVGTEVALPYGEPQISVSQGSTTVTLAATDYTRSGQLTSV
                     EVVPVYQHCSALADRMIAVVGSGMVVSSVGAPPDPRQSPDGCAAGAWQDQTATRAVFRG
                     MGAARIELVPDSATLPG"
     gene            complement(6166..7590)
                     /gene="ltrA"
                     /locus_tag="L3Q65_RS24360"
                     /old_locus_tag="L3Q65_24355"
     CDS             complement(6166..7590)
                     /EC_number="2.7.7.49"
                     /GO_function="GO:0003964 - RNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0000373 - Group II intron splicing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ltrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013672260.1"
                     /locus_tag="L3Q65_RS24360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24355"
                     /product="group II intron reverse transcriptase/maturase"
                     /protein_id="WP_237596721.1"
                     /transl_table=11
                     /translation="MNTDALEEAFFDAERRVLEIQAKLHRWAVDDPHRRFDDLYNLIAH
                     PAFLLVAWFRVRSNKGARTAGADGMTAHAVRWWRQDHLLLEQLRAELKAREFRPMPVRP
                     VNIPKAKGKVRRLGIPTVRDRVVQAVLKLVLEPIFEADFRPCSYGFRPNRRAQDAVTES
                     WHLASNSYEWIVEGDIEACFDRIDHTALMDRVRRRIGDKRVLLLIKAFLKAGILAQGGQ
                     IWGGDTGTPQGGILSPLLANVALSVLDENFDQYTISTVERAKRRRHGLANYRLIRYADD
                     FVIMVSGNRAQAEALLPEVAEVLGTVGLRLSAEKTLITHIDEGLDFLGWRIQRHRKRGT
                     DERYVYTYPSKKALRAITTKVKTACLQNVNDSLADLLRRLNPMLRGWTAYFRPGVSQAT
                     FQHLRSYVWHRVMRWIRKKHRRINWEKLRRRYCTATRDRWWPADGDVILFNPGSVSTTR
                     YRYRGTKIPSPWPSRA"
     gene            complement(<8196..8567)
                     /locus_tag="L3Q65_RS24365"
                     /old_locus_tag="L3Q65_24360"
                     /pseudo=""
     CDS             complement(<8196..8567)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009155827.1"
                     /locus_tag="L3Q65_RS24365"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24360"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSANSQVVARFVSVVMGLVIGLTFLFGFGNVLSLALKLQVPVFVA
                     PLVAPAVDLTVLGLLVGTRHLALSGASDDVLRAGRRLLTAASVGTLLLNVADPVCVGEW
                     GKAAFDSVGPFLLIGWAEVG"
     misc_feature    complement(9433..9445)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 18.12"
                     /tool="antismash"
     misc_feature    complement(9480..9494)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     misc_feature    complement(9633..9647)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.44"
                     /tool="antismash"
     misc_feature    9689..9698
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.0"
                     /tool="antismash"
     gene            10001..13117
                     /locus_tag="L3Q65_RS24370"
                     /old_locus_tag="L3Q65_24365"
     CDS             10001..13117
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="L3Q65_RS24370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24365"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_237596723.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 4.5e-169,
                     bitscore: 562.7, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 4.1e-09,
                     bitscore: 36.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4.5e-33, bitscore:
                     114.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDQESLFACADFVGVRAATLPLDAMARKSDSADVHDAEGLRSRIA
                     DLADKTLLDAVELASPSLAKAVASALSPGRQARAGELRRVAIALVKYRQRMAARPTPFG
                     LFAGLGLVEVGKGGRLRLGAGHQLFSRPDAAWLDAVLDLLRADPTLVRGRFLVSNPLCT
                     VRDGRLVLLDRYERDGVRRVESSVRHTRVATEALAAAEKPVQWEELADRLRRRFAIGPA
                     MDPVLSDALWHLVEGRFLLVDLEPPPDVHDQLAYVLDRLGGGAHPVVDELRQIRRCLRE
                     VDSAPSPGRAGPLRALMSGMRTLHYVEKPVQADLRLDIHGTMPEAVAREAERAATALWR
                     LGAVPRRTRWHEYHARFLEKYGTERAVEVVELLDPDRGLGTLDDGIGRTPRQEDETIAA
                     ARTRVLGELSVGAVRDRTSEVVLDEHLLTTLSPDADRLRTPDSLDLCAEVVAESWEALC
                     GGDFRLVVGPGTGSPMATSMFGRFAYMFPEWEERLSDFARETAPGPERSVPASVAFRPK
                     VSRSLNVATVPQWLSARIPLGVGPAQRDVRDLQLANLVVKATRDRLVLLDRVSGQQVVP
                     VLHSMLNRGERFVPEVARFLLDLGSQDLNPLRPWNWGRWADAPFLPRVRYGRTVLSPAR
                     WLPDATMRSQCRDPELWPAQVETWRERWGVPRSVRLATADRRLAVDLDDPLHLMVFSDE
                     LRRDPRLEVTEQPAGAHENGWLHGAAGAHAAELVLPMRRRTSRLEAAPPDRDEMVVKPV
                     PCRREDLLRLPGGEWLYAKLYASEPAQQRILAAKLPTLVADGCLRALGVENWFFVRYAD
                     PEPHLRLRFHGEAGALWGQLLPRLQAWSAELRVAGLLTSLCLDSYDPEAERYGGLAALP
                     AAERVFHADSQLSLALAPVVVRSDHEPSGAVLAAMSVLRLLLAFKPAAEVLDQITGWAD
                     TAERHRVSRTERESFASLITPDGYPRPDADLRDGGELTAMWQRRDLALARYASALAASG
                     TARPSTIAEVLAHLHCNRMFGTGRGSERSAYALIGEGLRLRSDRWRHGR"
     aSDomain        10469..10741
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_L3Q65_RS24370_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.30E-11"
                     /identifier="RREFam001.1"
                     /label="L3Q65_RS24370"
                     /locus_tag="L3Q65_RS24370"
                     /protein_end="247"
                     /protein_start="156"
                     /score="36.1"
                     /tool="antismash"
                     /translation="VSNPLCTVRDGRLVLLDRYERDGVRRVESSVRHTRVATEALAAAE
                     KPVQWEELADRLRRRFAIGPAMDPVLSDALWHLVEGRFLLVDLEPP"
     misc_feature    12506..12508
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            13114..14445
                     /locus_tag="L3Q65_RS24375"
                     /old_locus_tag="L3Q65_24370"
     CDS             13114..14445
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="L3Q65_RS24375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24370"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_237596724.1"
                     /sec_met_domain="LANC_like (E-value: 9.7e-44, bitscore:
                     148.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLDEALRKRATDTALLVAERLREPRSVARIAEASRQTLADGSYP
                     AWRPDGLWGGHAGISVLYARLSHHDDTWSAPAHAHLSAAASAAGTEHRTTFAGAEVALA
                     ASLFRAARGGYTRLLSQAAKAAANVGLARARRTLSAGQSVAETGGYDVITGLSGQGRIL
                     LLLAEQGFEDCAEALNEILRCLVPITEPVLAYGTEVPGWWTSPDNYPLPDDRLRYPRGD
                     FNIGLAHGIAGPLALFAIAQSAGHDVDGLRQASEHIVDWLLSWQAEDRFGPYWPSRISF
                     EDHAAQCLPDSIRVQTAWCYGTPGTARAIQLAGQVLGRPELSSVAAAAMCAAVERAAAG
                     QPRSSNLCHGVAGLLHVASRIGQDAEDGRLARLAAGLTRELIDRYDETVEFGYQESIPA
                     GRGYLGCNDPGLLQGASGIALALHTAANPDNETAPHWDAPMMLT"
     gene            14564..15820
                     /locus_tag="L3Q65_RS24380"
                     /old_locus_tag="L3Q65_24375"
     CDS             14564..15820
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF002367.0"
                     /locus_tag="L3Q65_RS24380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24375"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_237596725.1"
                     /transl_table=11
                     /translation="MPSSRAPDGSRYSLRTASDRDWRDLTRTIELSYGGHPDPAEVHQV
                     NKDLFEPERSLATYHRDKICATALVYSLNMTIPGGIQPIAGIGYVSVDPTHRRRGLMSE
                     MMANILHGLHHSGTEPVAALQPSESAIYSRLGFGAANQVVRLEIPRKPHAFSLLPRGED
                     LPATIIDPQTCLDEIRDVYQANVPQRAGMLHYDKRWAAKAVLDPPTARNGAAPLQCLTV
                     SEAGAPAGYALFTTRPQDDSPDPPLAVLVRELFATSPKAYAQLWRTLLDLDLSTTVIAH
                     TRPLDDTLLVLLDDPRSAVPTVRDQLHVRLIDVDRALALRTYSAEVDVVIETTDRLCEW
                     NVGRWRIQGGPEGASCTRTTSAPDLVMSVRELGSAYLGGISLTQLARAGRIEEMRTGAL
                     DAACRAFRTDPLPFCSLMF"
     misc_feature    15212..15214
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            15856..17100
                     /locus_tag="L3Q65_RS24385"
                     /old_locus_tag="L3Q65_24380"
     CDS             15856..17100
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013227.4"
                     /locus_tag="L3Q65_RS24385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24380"
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="WP_237596726.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 4e-85, bitscore:
                     285.3, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 7e-06, bitscore:
                     24.5, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAVPGPGYAFYDQEEERSVLAVLQALLNSRDTYGKPQLISQARS
                     FEEAAGERLNSPYCLSLNSGTSALLAGLAALGIGPGDEVIVPGFMFIATISTVVHSGAT
                     PVFAEIDTSLTLDPQDVRRKITERTRAIVAVHMLGASCDMAALSQIAEENGLYLIEDVA
                     QACGGTYRGAPLGTLGDVGAFSLDTFKVINGGGAGGFLLMKDGRLFQRAYSFHDQGWFP
                     GREETGDGDVIFGLNLRMPEFNAAFARAQLAKLDTVLERTRLVKSQLDKLIPLRPGLEQ
                     RRLNDPDGDCATVSVYLFDQPEAAQAVAQELGCSTLDKSRRHYYAQINALSPPPDQEAP
                     TCPFQHKPGEKRRNTLAPGELPRTDNLLSRAVALSVGLSDSYLGSGFGASVRSDPDELS
                     GIADRFSAAAAQALR"
     misc_feature    15934..15936
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            17159..18445
                     /locus_tag="L3Q65_RS24390"
                     /old_locus_tag="L3Q65_24385"
     CDS             17159..18445
                     /NRPS_PKS="Domain: Aminotran_3 (25-363). E-value: 4.8e-91.
                     Score: 297.2. Matches aSDomain:
                     nrpspksdomains_L3Q65_RS24390_Aminotran_3.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015800833.1"
                     /locus_tag="L3Q65_RS24390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24385"
                     /product="aspartate aminotransferase family protein"
                     /protein_id="WP_237596727.1"
                     /sec_met_domain="Aminotran_3 (E-value: 1.5e-92, bitscore:
                     309.5, seeds: 13, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 7.9e-05, bitscore:
                     21.0, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSSEQELIDKAVRDAIYYPVSDQSMQRGEGIYLYDLEDKEYIDC
                     ASATFNLSLGYGHPAVVSAIQQQAAELIHVTSSFQSAPISDLVRRLVEISPKNLTKVHL
                     KVSGGSEANEGAVKMAQYATGKKDVITLFRSHLGQTMMMASLSGNAFRRQPFPLTYPGG
                     LHVPDPYCFRCFYGQTRETCGLMCVDRIDDFIEFASSGRVAAVMVEPVSGNGGNIVPPD
                     GYFQQLRKFCDERDIALIFDEIQTGIGRTGQMFAAQHFDVQPDAITVGKGLGGAGAQVA
                     GILTNERLAGLPGNHHSFTYGANLLAAAAANATVDIIRQPEFLANVRSVGNHILARLAE
                     LKKSYPAIGDVRGIGLMLGMEIIEPDNSPAVKATNHLAAAAQRHGLIIRTSRYGYGNVL
                     KIRPPLIMTHDEADIVCDRLEMLFREEFA"
     aSDomain        17234..18247
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_L3Q65_RS24390_Aminotran_3.1"
                     /evalue="4.80E-91"
                     /label="L3Q65_RS24390_Aminotran_3.1"
                     /locus_tag="L3Q65_RS24390"
                     /protein_end="363"
                     /protein_start="25"
                     /score="297.2"
                     /tool="antismash"
                     /translation="MQRGEGIYLYDLEDKEYIDCASATFNLSLGYGHPAVVSAIQQQAA
                     ELIHVTSSFQSAPISDLVRRLVEISPKNLTKVHLKVSGGSEANEGAVKMAQYATGKKDV
                     ITLFRSHLGQTMMMASLSGNAFRRQPFPLTYPGGLHVPDPYCFRCFYGQTRETCGLMCV
                     DRIDDFIEFASSGRVAAVMVEPVSGNGGNIVPPDGYFQQLRKFCDERDIALIFDEIQTG
                     IGRTGQMFAAQHFDVQPDAITVGKGLGGAGAQVAGILTNERLAGLPGNHHSFTYGANLL
                     AAAAANATVDIIRQPEFLANVRSVGNHILARLAELKKSYPAIGDVRGIGLMLGMEII"
     gene            18442..19380
                     /locus_tag="L3Q65_RS24395"
                     /old_locus_tag="L3Q65_24390"
     CDS             18442..19380
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1207: inositol monophosphatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003156785.1"
                     /locus_tag="L3Q65_RS24395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24390"
                     /product="inositol monophosphatase family protein"
                     /protein_id="WP_237596728.1"
                     /transl_table=11
                     /translation="MKNLIVGLAQAIRTEVLARRPVGAGRSVLHDSPGGDAQFDIDEVA
                     EEAIWRYLKSECGDPIAVYTEDHGLRNLGRNPRHLLVIDPIDGTRPASAGLEMANVSIA
                     SAPMSEDPIMSDVDHALLMELSTGRWMYADANSPELTTEGYIQQIPCLSANDDLARMFW
                     SIEFNGHPMHLMNTAYGHLVNQSANTGGVFVFNSASFSISRLITGQLDAYVDIGNRILR
                     DRPETREEFLAAGRGNILHLFPYDIAASVLLAERSGVTITDAYGEPLGKTRLLDLAPTN
                     QQSCIAAANPRLHERLLDSIEWSSDDNGIVR"
     gene            19388..20431
                     /locus_tag="L3Q65_RS24400"
                     /old_locus_tag="L3Q65_24395"
     CDS             19388..20431
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012335.4"
                     /locus_tag="L3Q65_RS24400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24395"
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_237600935.1"
                     /sec_met_domain="ADH_N (E-value: 1.1e-31, bitscore: 107.9,
                     seeds: 66, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKALALTEDQTLQLVDRPDPIASGPRDVVVKVTQTGICGTDRSVL
                     VGKFRAAPGTIMGHEAIGVVAETGPAVTGLRVGDRVVVNPTLYCGRCDYCLRGKRNHCL
                     NKAGTEVGIDRDGSYAEYIVLEDLFLHLIPSDTSDDRAVLIEPLACVLNNIDAARMTPA
                     STVTVLGGGPIGLLCVLVLAHFGHPVTLVEQDTYRRSFATTFLDGVPENSVRIVGADEL
                     GQLPGTDVVIDTVGGLLDKALAHVSAGGLVVIMGFDSRAAVTVRPLEILQRGISIVGAG
                     DFQPEVFPRAIDLARRLPLERLITHRFPLERHDEAFQALAGTVGRSANYSAQKVVIQSS
                     SPANDAH"
     misc_feature    complement(20443..20457)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
     gene            20460..22451
                     /locus_tag="L3Q65_RS24405"
                     /old_locus_tag="L3Q65_24400"
     CDS             20460..22451
                     /EC_number="3.2.1.23"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013469.4"
                     /locus_tag="L3Q65_RS24405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24400"
                     /product="beta-galactosidase"
                     /protein_id="WP_237596729.1"
                     /transl_table=11
                     /translation="MPGRPVAILADYPYYRADPGNWPGNLKTLRSLGVDVITAYVPWRL
                     HEVETSQGHRRYDFDGSTQPHADLIRFLRLVDEADLLAILKPGPFIHGEVDFGGLPDRL
                     DTGKMTATANWAGAVRTSEGHPLPSAFDPRFQEEVRTWLNAVRDQVLLAHTRPHGPVVA
                     AQLGNEGLYGETAEAMTDCDFSDAARCGTGSAVDWPPASPSSRAKWARSISSALRDRLT
                     EFRDALGDCVPTVVNLPLPDIGGTRRELEAWLCRVVRIVPDRTLPGHNTVWTGNLIRSE
                     SVLSAYWFGVRAIDADTMEDNWGFTWTDPSYATPAVPAHYSLLDLALGSTTLSVYTACA
                     TRNWPPVIAPDESVLGDSSHLYAPPYCSGAPVDESGNIRPNARALRLLSQFLDWHGTAL
                     RKTRASTTASLLVDPVTVAADAWPDEDDQPGRALRTAVEGCTRWMMRSGQDVDVTVGRI
                     PLDSGSRRNPIIVAGGRGMTAALQEGLAVEIRSGRPVVFVGELPTLDEHDNECVLLRTA
                     LESPDAVARVFDPSGESPAHTLHEVLRHIAEDRPAAPGVLRLVRSDDQTGSEFTFLFNR
                     NETRQLATGTRRSVDFSIELEPWSSTALVWTGKALTGFVVAAGADSSSGEQLRPMRVGD
                     ETFGGPNIGDAVGRRAGSGWEILTFSDH"
     misc_feature    22011..22013
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            22492..23721
                     /locus_tag="L3Q65_RS24410"
                     /old_locus_tag="L3Q65_24405"
     CDS             22492..23721
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014734.4"
                     /locus_tag="L3Q65_RS24410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_24405"
                     /product="galactosyltransferase-related protein"
                     /protein_id="WP_237596730.1"
                     /transl_table=11
                     /translation="MPAVKEDSCDSIAAQYVEYIALALDPATRTISATSWEHSAEYYRW
                     ATEKLVSITKTSPEIQNSYNALRASPTDPEPYFALRNSLALHLAASPAIRAEISQHLDQ
                     SLARNEIGYHVGTSYRRDVAAVHSDMLQAKCEETIRREPPRSEVDVQIIIPFRDSENSG
                     RLRNLLALLLALQDQSMPRHRYATTVVEADEIPRWKPALTPFVDHYLFACKSGKFNKSW
                     TVNTGVVNTEVKPKFLCILDADMLPDRHFLARNAARLSQVDNSAHLPYHRGGLLSLDAP
                     ASNASIKERCFRAEPEVDLSLLRGHVLLAAPGGSVWTHTSLFHRIGGFDERYEGWGGED
                     DDFVDRLTEAGTFRRFSDYTMHLHHSRPQMRAAGHPFNSWIQPHGWTSRNRYGQLTKFL
                     HGQENQGDDA"
     misc_feature    22741..22743
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    22996..22998
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(24085..24101)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.47"
                     /tool="antismash"
     misc_feature    24254..24267
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.06"
                     /tool="antismash"
ORIGIN
        1 ggtcgtcgag atgctcttgg acggatgcga caacttggcg gtcccgggaa tgctcttcgg
       61 tcttctggtg cgtcatgtcg agaagctcga cgcagaactc gacgcgttcc tcgccgagcc
      121 gattgtctgg gaactcgagt tcggtcgtca gacaggcgag tactcgggcc tgcgcgcaag
      181 aaccgaagga ctcgcaaacc tggaacgccg ccggtggaca ccacgtgaag cggccgtgtg
      241 gatgatgacc cacggtggag aagcgcgcgt tctagccctg aagaaggccg ccgagcaact
      301 ggtcaagaac ggtgaccggc tcggcataag ccaagaccgg acgaagaact gggccgccag
      361 cctcgactcc gaacagtacc gaatcgcgca gcatggcgat gagcactaca tcgaggtcgc
      421 tccgccgcct gaggtcgaag ccgcgctgga gaggcacgcg gcgcaccagg aggtcgtgca
      481 aaccacactg cggttgcaga acaggtactg gggctcagtc aagcacgact ccgattacgt
      541 gcccccgtcg ccggaagaga tcgctgcgga cctggttatc ggtcgtgaat tgctcgagtc
      601 ccatgaggac acgacgacct ggtctgtgaa cgcagtgtca catgtcgtcc gcgcagcggt
      661 cgaacgaggc gcagccggcg acctccatgc attgggcgac gagagcaact ttgcgatcga
      721 attcattctc aaaattgcct tatcgttcca ggacgcagag gaccaacgcg acgaggggca
      781 gtacttcgac cagggtgctg accgggccgt cgcccatgcc ttgccagctt tgctcacatc
      841 gccgatggct gtgcccttgc aaactgcggg aagcttcatc gaggacgtgg ccgaggccgg
      901 ctttgctatg gcaggaaagg cgtcgctgga gactcggctg tacctggcgc gtggatgcga
      961 cgtcgtttgg aaagcggcct gccacggcga tccttgcatc caccgcatcg caatggactg
     1021 gttggtcgag accgctcgca tcgcagaagt cgggccgtgg gaccagggcg gccagatgcg
     1081 gctgagtgtc aggattgtcg gcgacgtctc cgaccgcctc caggagttgg acggagactc
     1141 cgtcgacttc gcggtgctcg acgccgtcat ccgcggactc ggcaaggctg cggtcgtgga
     1201 ccactgctgc acccaggacg cggcggtgaa gttcgccgct cttctccagg tacagcgaca
     1261 tgccatgatc gtccacgcag aagcagtcgg gacagcggac gaccgaggga cgcacaccct
     1321 cgtcgccgca cgtgccctgc tcgacgggtt tgccaggaac agcgacatcg gaccggtgct
     1381 cgaacatctc gatgccgtta gcgtgaacgc cagcctgatg ttgagcttcc ttcatggtct
     1441 cgcggcggcc ggcgcagaaa ccgaacgact tgctgaggcc gcccggggtg tttggccctc
     1501 gttgctggcc cacgccctcc ggtacctggg cgacgacgtg agcccctacg aggaccgcca
     1561 ctggggcgac tggaccgcgg cggctctcct gccagaccct ctgccctggg tacaaggcat
     1621 gtacaacgaa atcatcagcg caccgatcga ctgggtccgc cccgaagacc tcctcagcct
     1681 catagatgac tggctgccca ctgcccgagg gaaggcgaag tgcgtcgacg cgctcatcgg
     1741 catcctgcgg aagctcacgg tcgacgttca ggtcactcgc ggcctgccct gggtgtccga
     1801 cctgtgcatc caagacggcc gcgtcactgt caaacagtca tggctgtcga acgactggct
     1861 caagaagact cgcagcgccg cagaggagct tgatcgtctc aacgactggc agatgctcgt
     1921 cgattccctg gtcgtcgccg ggaacgaagg actggcacca tacagccgct gatgtctcgc
     1981 ggtgccccgt ccccgtgcct ctcgggactg cagtagtccg cccaaaccgc aaagcaacat
     2041 gtcgcgcacg aatcggtccg cctgccattc ggcggcgaat accgtcgacg acagaaagcg
     2101 caccagatcg ccgacgagat gggaaacggt caggcgtttc gaactgcctc ggtcagcggc
     2161 cgccgctgga agtgccttgg ttggcgggcg aagatggtgc ggtggcggcg ggtggaggtg
     2221 tgaggacgcg ttcaaccaag gctcctgcgg caccggagcc cagcgcggtc gcggcagcgg
     2281 tgagcacagc gaggagaagt gtcgaggcgg aggccgtcag cgcgttcatc cggtggagtt
     2341 cccggaggtg gcgcaagccg taaccatggc accggaggac ctgccagtcg gccatcaacc
     2401 ccagaatcag gccgaacgac agccactgcg cgagttggag cgtcgcgctt gcgagggcgt
     2461 cgtgcgcacg cgggtccggg agcaacgtaa ggcagagagc cggcccgctc atggcgatga
     2521 acaggctgaa gcccttggcg agcccggtgg ttccgcggac cagcgggtac gcacctccca
     2581 cgatcagccc ggcgatggcg aaccgcagga tgaccaggat gccggccgcc gtgtcgacga
     2641 gccggtacgg cccgtcgccc gtcagcgtgc tgatcgctgc cgcgacgtcc agaacggtcc
     2701 acggaagccc gatcacgaac ccgaggccgg cgaactgccg cgcgttccgc catgcggtcc
     2761 cgccaccgta ggacgagaag gcgaggcgcc gtcgctccgg cgaaagccgg tgttcgccga
     2821 gcgcgagttc agtgatccgc tccagccgac ggttctgcgt gtcttcgtct ggcgcgtcct
     2881 cggcgagctt ctgccgcagt tctttttcga gcgctgcctc ggtcctagcg gtggcagcgt
     2941 cgcggaccac cgctcgtacc gcagctgtcc ccgacgcgtc aacagcatca ccggccgcgg
     3001 cacgctcggc gtcgtcagcc ggacggggca gcagccacac ctcgaccagg gcccaaccga
     3061 tgaagaacgc gaccggcaag ccgggagtgg tagccgaagg actcaggatg cccacgacag
     3121 tcaaaaggac ggcgacggcg cggatcagcc ggggagtacc gcgtattgct ccgtcccccg
     3181 tggcggatcc gaggtggcgc attagcagca gcaggaagcc gaagacgaac agtggcagcg
     3241 caccgtccac agatgatgcg aaagtgccga agtcgtacca ggtcatcggt ggtacgccgg
     3301 cacctccgta aacgacgagc gggacagaca gcagcagcgc tacgacgacg cgcacgccgc
     3361 gccagcgccg caggaacggc catcggccga gccagaccga cggaggtgcc gcctcgagcg
     3421 cgtgccgggc gacccggtcg agtgtcagcc agacgaacac cgccgccgtc agcgggaccg
     3481 ccgcgccgac cgcggtaccc aagaaccctt gtcgagcggt caccggctcg atgagcagca
     3541 ggagcgcggt gagggtgacg ccggcgacca tggtgagccg gtcgcgcggg cgcagcctca
     3601 gggcgcggcc gagaatattg atgccgaacg cggcgacgag catggccagg tagagcgcga
     3661 cgaggtgccc ggaccgtccg ctgtaccact cggaccatcc cggttccgcg gcccaccaga
     3721 gccagccgtt ccgcacgacc aagtcgagca agcccgccat cagcatcagc aaggcggcgg
     3781 cgacgaacca ctcgacgaca atcgccaaca ccgaccacca aagcggtcgg cccgtcccgc
     3841 cgatgcgtgg attcggtctc cgtaccaacg ccaggaaggc gaccagcagg gcgagaaaac
     3901 ccagaccgac gaacaccatc gccaagacgc ccggttcagt cgaaagccac gctgccaacg
     3961 tgcggggcgc gtccgggtcg tcccacggcg accacaaggt ggcctgaccg atgaggacga
     4021 gaaagccggc tccggtgagc agcgccgcga tccaggcgat ccggccttgc gtcttcggtg
     4081 tcgctcccgc gagtttcgcc accaggaacc cgacgagggc agcgacctgc aacatccaaa
     4141 tgacaacaag caggacggcg agccaggtgg cccagaacga ccgcccggtg ccggtagtcg
     4201 cctgcgtcga cgcgccgggc cacatcagac cggtcggcac gaggactgcc gcacttgcga
     4261 cgacgatcca cccgacgtcc ttcgcgatcg acgatcggcg gtccgtggac acggtaaccg
     4321 agcggagcgt gaaccgccgc cagacgaaag cggaagcgat aacggtcgcg gccgggacca
     4381 ctgcaccagg acgcgccatg accgagtcca gcgcggcgtc cggcagggag aatagcttct
     4441 cggtcaagta gctcgaggcg agcgagacta tcaggcccac cccgacgaca acgtgcagaa
     4501 ccaacagcgc gcggacgatc gcggctgtcc gcgacccgag cgtgtccaca gcggaccgct
     4561 gccggagcga tggctgtgcc gagctcgccg gcgaaccggc gcgcgtgcgc gtccggcgtg
     4621 gacgacgcaa ccgaaaccag gcgatcacca gcggtgccga actgagcagg gtatagcgga
     4681 tcgcgttcag caagccggcc gagtgcccgt ccgcggcgat caagggcatc cggaggtccg
     4741 gctagccggg tagagtggcc gagtcgggca ccagttcgat ccgagcagca cccatgccgc
     4801 ggaacaccgc tcgggtcgcg gtttggtcct gccatgcacc ggccgcgcag ccgtcgggac
     4861 tttgcctcgg atcgggcggt gcccctaccg acgacaccac catgcccgac ccgacgacgg
     4921 cgatcatccg gtccgccagc gcggagcaat gctggtacac gggaacgacc tctaccgaag
     4981 tcagctgccc tgacctcgtg tagtcggtcg cggccaacgt caccgtcgtc gaaccctggc
     5041 tcacggaaat ctgcggctcg ccgtacggca gtgccacctc ggtcccgacg cctacagacc
     5101 acgccagcgc caaaccacgc ccgcgcgcgt ggccttgccg gaccaattcg agcagcggat
     5161 tgctcgtcgg gccagtgatc gacagcgaga gcttcgcgcg cgggacgtcg ccagaagaac
     5221 cgggcgcgac gacggtcaag gtggcagcca cggacaagga cttggccgga ctgcggcgaa
     5281 gagcgtcctc caggtccggc gaggtcaccg tggtgttcgt gacccagggc tcgggtgcgt
     5341 ccttgactag ttgttcggca ggggaagact cctgccgcaa cacaccactt acgtaggtaa
     5401 gcgccacgat cgcgagcagc agaccgagga cgccgaggag cgcgcgggcg acaacacgca
     5461 ttcgccgccc tccagcaccg agatcaccag tcccagataa atcgcagcag caagtaaagc
     5521 gttacgccgc ccacagcctg ctcgaacctc gacgagatac acggcttcca cctgctcgac
     5581 ggctcgtacg ccgacaaccg ggataaggat gagaacgaag aactcaacga acgacttgac
     5641 gcctgatcag cgaacgcggt tccggcagaa gccatagcca accagaaccg gctgacctgg
     5701 ccggacacga cggcggaatc cggctcggct caagtaaccg ccgccacggc tgagccgggc
     5761 ccgtcgcgcc actccgcgcg gaccacccgc gtcaacatgc gggagcggcg agccccaatg
     5821 cccaacgcct ttcgcagcac ctccgccgaa accggacgct gatgccgcgc acgatgctcc
     5881 gcgtcaatct gccgagcccg ctccaccaga cctgggtcaa gctcaacttg cctcttaccc
     5941 ggatcgtccg acgacaaccc aggctggccg tccgctgaca catcaggatg gcggtcagca
     6001 gcgacgtgca cgtcggcgaa agcctgcagg aggcccgggt gaggtcgact cggggcgcgg
     6061 tgctggcctt gcggtcagtc cgtttccccg agccgcctcc cgcaccggac atgcgcctct
     6121 caacgcatcc ggcgctccac aaaccccgtt ggctggccgg tcgtctcacg ccctgctcgg
     6181 ccatggtgac ggaatcttcg ttccccggta ccggtagcga gtagtgctca ccgacccagg
     6241 attgaacaag atcacgtcac cgtctgcggg ccaccaccga tcacgtgtcg cggtgcagta
     6301 gcggcgacgc agtttctccc agttgatccg gcgatgtttc ttgcgaatcc agcgcataac
     6361 ccggtgccac acatatgacc tcaggtgctg gaaagtcgct tgagacaccc ccggccggaa
     6421 gtaggccgtc cagccccgca acatcgggtt cagccgacgg agcaggtccg ccagcgagtc
     6481 gttcacgttc tgcaagcacg ccgtcttgac cttcgtcgtg atcgcgcgca gcgctttctt
     6541 cgacggatag gtgtagacgt agcgctcatc tgttcccctc ttgcgatgac gctggatgcg
     6601 ccaaccgagg aagtccagac cctcatcgat gtgagtgatc agcgtcttct cggccgacag
     6661 gcgaagcccc accgtaccga gcacctctgc cacctccggg aggagcgctt cggcttgtgc
     6721 ccggttgccg gacaccatga tcacgaagtc gtccgcgtac cggatgagcc ggtagttggc
     6781 gagtccgtgc cgacgccgtt tcgctcgttc cacggtgctg atcgtgtact ggtcgaagtt
     6841 ctcatccagc accgacagcg ccacgttggc cagcagcggt gagaggatgc caccctgcgg
     6901 agtgccggtg tcgccgcccc agatctggcc accctgggcg aggatccccg ctttcaggaa
     6961 ggctttaatc aacagcagca cgcgtttgtc cccgatccgt cgacgcaccc ggtccatcag
     7021 ggccgtgtgg tcgatccgat cgaaacaagc ctcgatgtcg ccctcgacaa tccactcata
     7081 cgagttggac gccagatgcc acgactcggt caccgcgtcc tgagcacgac ggttcgggcg
     7141 gaacccgtag gaacacgggc gaaagtccgc ctcgaagatc ggctccaaca ccagcttcag
     7201 gaccgcttgc acgaccctgt cccgcacggt cggaatcccc agccgacgaa ctttgccttt
     7261 cgccttcggg atgttcaccg gccgcacggg catcggacgg aactcgcgcg ccttcaactc
     7321 ggcccgcaac tgctccaaca gaagatgatc ctgccgccac caccgcaccg cgtgagcggt
     7381 catgccgtcc gcaccggcgg tcctggcgcc cttgttgctc cgcacccgaa accacgccac
     7441 cagaaggaac gcgggatggg caatgaggtt gtacagatcg tcgaaccggc gatgaggatc
     7501 atcgaccgcc caacggtgca gcttggcctg gatctccagt acccggcgtt ccgcgtcgaa
     7561 gaacgcttcc tccagcgcat cggtgttcac cgacgacctc ctggcattcc agcatccgca
     7621 ctgctggctt gctggccccg ttcgccatgt ggacggcttt cccgtcctcg gactactacg
     7681 gagcctccgc cccaccacgc gccttcgacc gacgatgcgc ctatcccgat cccggcctgg
     7741 ccggccggtt ccgggaacga cacgcgatgg ttcccacgtt cactgcttga ccgatcgacg
     7801 gagtaggcac ccaactcctg cccctgcggc atcgccgcgg gtacgccgtg aaccttcccc
     7861 gcggcctccc tccggtcatt ggtaaaccag atcgggagtt cgcccggaca ccgtccgggg
     7921 tgcgcgccgc actccagccc atatccgcca gatttgagct ggtggtccgc ttgaggagcg
     7981 ttactcgctg gttcctgcac gtataccttt ccgtctcgct cgccggaccc gaaccgtctg
     8041 gcagtaccgg cccgtcccgg ctttgtcagg gctgcttgcc gccctcaccc gcatctccgg
     8101 gctcaggctg ccctcagctc cacgccgccc gtcacgacag acagcggatg gagtcctctc
     8161 acctccactc ggtcaaacaa cgcctcgtgg cgcacgccaa cctcagccca cccaatcagc
     8221 agaaacggac cgaccgagtc gaatgccgcc ttaccccact cgccaacgca cacagggtcg
     8281 gccacattca acaacagcgt cccgacgcta gccgccgtca gcagacgccg acctgcccgc
     8341 agcacatcat cactggcccc ggacaaagcc aggtgacgcg tgcccacgag caaccccagc
     8401 accgtgaggt cgaccgcagg cgctaccagc ggcgccacga acacaggtac ctgcagcttc
     8461 aacgccaagc tcaacacgtt tccaaacccg aatagaaacg tgagcccaat gaccagcccc
     8521 atcacgaccg agacaaaccg agcaaccacc tgcgaattgg cgctcatgac gggctcccac
     8581 ctgaactggc ctccgaacaa gaccccgacc tccgacgaat gacgcggctt ccgcatctga
     8641 cgatgctgtg ctttcgccgg ccgggtcgaa accggcgacg attcgggccg gggcaggctg
     8701 gcaggagctg ccggaacagg ccgggacggt agtcgggtgg cggcccgggt ctccagtccg
     8761 acggatcgac cgcggcaaca cctgctggtt ccgcaatcac tgcggacagc ctgctcaaag
     8821 gacggaaacg caaggtcctg ctggcaatca cacggggtga gcggtgttcc cggccgaccg
     8881 gtgagcgata ttccccgcac aagcgggatc atccacaaac gtccgcgacg agagtagcgc
     8941 ccagttccct gtgcgaatgg aggatggtcc ctggcctggt gagaccatcc cgaccgcgtc
     9001 ggttctcccc gctcgagcgg gagtggtccc gttgcgcagg ccctcggcga ctcggcaatc
     9061 ctgttctccc cgcgcgagcg gggaaggtcc tgggtcggcg cgctcgacga gcgggggtgg
     9121 tccgctcggc acgatccggc tggcggcgcg gtggtgtcct ccccgcgcgt gcggaggcgg
     9181 tcatcgccga cgccagtcga cctcgccgcc acccgcctag gctgagtgca gcttcccatc
     9241 catgcgccac gacaccatcg gcactgacct tgacccgccg cacacccttg ctacgctgcg
     9301 cccgcgaagc cccttcctag tcagagaacc tggaccctag acaagtccca gttcccctta
     9361 cccggcaggc acttcgcccc atttcaaccc acatcacacc aatccacatg aacgcccggg
     9421 ctagttgcct catcgccaat tgcaagccgt cagtcccggg catgcctgat gcgcacgtca
     9481 tcgacgaccc tgtttgacac tgacggcaac tgcggaaatt ccgcagttgc caccaccacc
     9541 tagcaaccga ggaagttccg cagttgccgc cctgggcata ggcgcccgtc ttcacttcca
     9601 atcactctgg tgctagaagt agaacgtcgc cttgaacacg acaagcacat cccgtgagac
     9661 acggtttgca atgcacagat gagcgtttta ttgtttgaag cttctcgaaa tcaagggtcg
     9721 tttaatagcc ggatcaacaa accacattct tcttccagga ggacaactat gccgagcaat
     9781 cccgttcttg atgaagcaga agattttgat ctcgacttgc gagtagagcc cgcccctgct
     9841 actcaggttc acgcgctcag cgcgcaacct agtccggcgt acacaatcga tctgacctgc
     9901 gtgcataccg tttgcccgac aatctgcggg ggatgctgac gcgaatcgcg ttgcgttccg
     9961 cagccgacgt ggtgctggca gctcatcgac aggggacgag atggaccagg aatctctctt
    10021 cgcctgcgcg gacttcgtag gagtgcgtgc ggcgaccctt ccgttggacg cgatggcgcg
    10081 caaatccgac agcgcggacg tacacgacgc ggagggattg cgctcgagaa tcgcggactt
    10141 ggctgacaag accttgctgg acgccgttga actggccagt cccagcctcg cgaaggcagt
    10201 cgccagtgcg ctgtcgcccg gccggcaggc acgagccggc gagctgcgcc gagtggcgat
    10261 tgccctggtc aagtaccggc aacgaatggc agctcggccg acgccgttcg ggctgttcgc
    10321 cgggctggga ctagtcgagg tcgggaaggg cggccggttg cgactcggtg ctgggcacca
    10381 gttgttcagc aggccagacg ccgcgtggct agatgccgta ctggacctcc tgcgcgctga
    10441 cccgacgctg gtccgcggtc gtttcctggt ctcgaacccg ctgtgcacag ttcgagacgg
    10501 ccgcctcgtg ctgctcgatc gatatgagcg ggacggagtg cggcgggtgg agtcgtctgt
    10561 ccggcacact cgcgtggcca ccgaggccct ggccgccgca gaaaagcccg tgcaatggga
    10621 agaactcgcg gaccggctgc gacgcaggtt cgcgatcggg cctgcgatgg acccggtgct
    10681 gagcgacgca ctgtggcacc tcgtcgaagg ccgcttcctg cttgtcgacc tcgagccgcc
    10741 gccggacgtc catgaccagc ttgcttatgt gctcgaccgc ttgggcggcg gtgctcatcc
    10801 ggtggtggac gaactgcggc agatccggcg gtgcctgcgc gaggtggaca gcgctccgtc
    10861 gcccggccgg gcggggccgt tgcgagcgct gatgtccggc atgcggacct tgcattacgt
    10921 cgagaaaccc gttcaggccg acttgcggct ggacatccac ggcacgatgc cggaagcggt
    10981 ggcgcgtgag gccgagcggg cagcgacggc actgtggcgg ctgggcgcgg ttccgcgccg
    11041 aacacgatgg cacgaatacc acgcgaggtt cctggaaaag tacgggacgg agcgagcggt
    11101 cgaagtggtc gaactgctcg acccggatcg cgggctggga acgctcgacg atggcatcgg
    11161 gcgtacgccg cgccaggagg acgagacgat cgccgcggcg cgaactcggg tgctgggcga
    11221 gttgtcggta ggcgcggtcc gggaccggac cagcgaggtc gtgcttgacg aacatctgct
    11281 gaccaccctc tcccccgacg ctgatcggct gcggacgcct gactcgctgg atctgtgcgc
    11341 ggaggtggtc gccgagagct gggaggcgtt gtgcggcggc gatttccgtc tcgtagtcgg
    11401 gccgggaact ggttcgccga tggcgacgtc aatgttcggc cgattcgcat acatgtttcc
    11461 ggaatgggag gagcggctct ctgatttcgc ccgcgagacc gcgccgggtc cggaacgaag
    11521 tgttccggcg agcgtggctt tccgcccgaa agtgtcccgg tcgctgaacg tcgcgacagt
    11581 tccgcagtgg ttgtccgcgc gcattccgct gggggtcgga ccggcccagc gcgacgtccg
    11641 ggacctgcag ctggcgaacc tggtggtcaa agccacccga gaccgcctcg tgctgctgga
    11701 ccgcgtcagc ggacagcagg tggtgcccgt gctgcactcg atgctcaacc gcggcgaacg
    11761 attcgtgccc gaggtagcgc gattcctgct cgatctgggg tcccaagacc tcaacccgct
    11821 ccggccgtgg aattgggggc gctgggcaga cgcgccgttc ctgcccagag tccggtacgg
    11881 acggaccgtg ctgtcgccgg cgcgatggct gcccgacgcg acgatgcggt cgcagtgccg
    11941 ggatccggaa ctctggccgg cccaggtgga aacgtggcgg gaacgctggg gggtgccccg
    12001 gagcgtgcga ctggcgaccg ccgaccgccg tctcgcagtc gacctggacg accctcttca
    12061 tctcatggtg ttcagcgacg agttgcgccg cgacccacgc ctggaagtga ccgaacagcc
    12121 tgctggagcg cacgagaacg gctggttgca cggcgcagcg ggggcgcatg cggccgaact
    12181 cgtgctgccc atgcgacgtc gcacctcccg cctggaagca gccccgccgg atcgcgacga
    12241 gatggtcgtg aagcccgttc cttgccgccg ggaggatctg ctgcgattgc cgggcgggga
    12301 gtggctgtac gccaagctgt acgccagcga gcccgcgcaa cagcggatat tggcggccaa
    12361 gcttccgacc ctggttgccg acggctgcct tcgcgctctt ggcgtcgaga actggttctt
    12421 cgttcgctac gccgaccccg aaccgcacct ccggctgcgt ttccacggtg aggcaggcgc
    12481 gctctgggga caacttctgc cgcgtttaca ggcgtggtcc gcggagctgc gcgtggcggg
    12541 tttgctgacc tctctctgcc tagacagcta cgatcccgag gccgagcgct acgggggtct
    12601 cgcggcgctg cctgccgcgg agcgggtctt tcacgcagac agccagctca gcctcgccct
    12661 cgctccggtc gtggttcggt ctgaccacga accgtccggt gccgtactgg cggcgatgag
    12721 cgtgctgagg ctcctgctcg cgttcaaacc ggcggcagag gtcctcgacc agataaccgg
    12781 gtgggctgac accgcagagc ggcaccgcgt gtctcgtacc gaacgagaaa gcttcgcctc
    12841 gttgatcacg ccggacggat atccgcggcc cgacgcggat ctgcgcgacg gtggcgaact
    12901 gaccgcgatg tggcaacgac gcgatctcgc gctcgcccgc tacgcgtccg cgctggcagc
    12961 ctccggcaca gcccggccca gcacaatcgc ggaagtcctg gcacacctgc attgcaaccg
    13021 gatgttcggc actggccgcg gctcagagcg gtcggcctac gcgctgatcg gagaagggct
    13081 gcgcttgcgt tcggaccgtt ggaggcacgg acgatgacgc tcgacgaagc cctgcggaaa
    13141 cgcgcgacgg acaccgctct gctagtcgct gaacggttgc gagagccgcg atctgtggcg
    13201 cgcatcgccg aggcctcccg ccagacgctg gccgacggga gctatccggc ttggcgtccg
    13261 gacgggcttt ggggcggtca cgccggcatc tcagtgctgt acgcccgtct ctcccaccat
    13321 gacgacacgt ggtccgcgcc tgcccacgca cacctcagcg ccgcggcgag cgcggccggg
    13381 acagaacatc gaacaacgtt cgcgggcgcg gaggtggcgc tcgcggccag tctcttccga
    13441 gccgcccgcg gcggctacac caggctcttg agtcaggccg ccaaagctgc tgccaacgtt
    13501 ggcctcgccc gcgcccgccg cacgctctca gccggtcagt ccgtcgcgga gaccggcggc
    13561 tacgacgtga ttaccggcct ttccggccag ggacgaatcc tgctgctcct cgccgagcag
    13621 ggtttcgaag actgcgccga ggccttgaac gaaatacttc gttgtctcgt gccgattacc
    13681 gagccggtcc tggcctacgg gaccgaggtg ccgggttggt ggacgtcgcc ggacaactac
    13741 ccgctgcccg acgaccggct ccgctatccg cgaggagact tcaacatcgg actcgcgcac
    13801 ggaatcgcgg gaccgctggc gctgttcgcc atcgcccagt ccgccgggca cgacgtcgac
    13861 ggactgcgac aggctagtga acacatcgtc gactggctcc tgagctggca ggcggaggac
    13921 cggttcgggc cgtactggcc aagccggatc agcttcgagg accatgcggc gcaatgcctg
    13981 ccggacagca ttcgggtcca aacggcctgg tgttacggca ctccgggcac cgcccgcgcc
    14041 attcaactgg ccggacaggt gctcggaaga ccagaactca gctccgtggc cgccgcagcc
    14101 atgtgcgccg ctgtcgaacg cgcagccgcc ggacagccga gaagctcgaa tctgtgtcac
    14161 ggtgtcgccg gcttgcttca cgtcgccagc cgtatcggcc aggacgctga agacggccga
    14221 ttggcccgcc tcgctgccgg gctcacccgt gaactgatcg accgatacga cgaaaccgtc
    14281 gaattcggct accaagaaag cattccagcc ggacgcggat acctcggctg caatgatccc
    14341 gggctgctcc aaggcgcttc cggcatcgcg cttgccctgc ataccgccgc caacccggac
    14401 aacgagacgg cgccgcactg ggatgcaccg atgatgctga cctgaccagc gatccacatc
    14461 gaccggccgg gtcggcggct tgttttacgc tcgtcccgcg ccggcgacct cgacacctgc
    14521 ctttgtcaac tcgccggcct cagccgggaa accaaggaga atcttgccgt cctcacgcgc
    14581 acctgacgga tcccgctatt cacttcgcac cgcgtccgac cgcgattggc gcgatctgac
    14641 tcgaaccatt gagctgtcct acggcgggca ccctgatccg gcagaggtgc atcaggtcaa
    14701 caaagatcta ttcgaacctg aacggtctct cgcgacgtac catcgcgaca aaatctgcgc
    14761 caccgcactt gtctattccc ttaacatgac aattcccggt ggaattcagc caattgccgg
    14821 catcggatac gtcagcgtcg acccgaccca ccggcgaaga ggcctgatga gcgagatgat
    14881 ggccaacatc ttgcacggcc ttcaccattc cggaacggaa ccggtcgccg cgctgcagcc
    14941 gagcgagtcg gccatctatt cccggctagg cttcggggct gcgaaccagg tggtacgtct
    15001 cgagatcccg cgcaaaccac acgccttctc cctactgccg cgcggcgagg acctgcccgc
    15061 aaccatcatc gacccgcaga cctgcctcga cgaaatccgc gacgtgtacc aggcgaacgt
    15121 tccccaacgg gccgggatgc tccattacga caaaagatgg gcggccaagg cagtactgga
    15181 cccgccaacc gcccgaaacg gtgccgcgcc attacagtgc ctcacggtca gcgaggccgg
    15241 tgcgcccgcc ggctacgccc tctttacgac tcgcccccaa gacgacagtc ccgatccccc
    15301 gctcgccgtt ctcgtccgcg aactgttcgc gaccagcccg aaagcctacg cgcagctgtg
    15361 gcgaacactc ctggacctgg acctcagcac caccgtgatc gcgcacacgc gccctctcga
    15421 cgacacgctt ctcgttcttc tcgacgaccc gcgcagcgcg gttccgaccg ttcgcgacca
    15481 gctgcacgtc aggctgatcg atgtcgaccg ggcccttgcc ctcagaacgt attcagccga
    15541 ggtcgacgtc gttatcgaga caacagatcg tctttgcgag tggaatgtgg gacgatggcg
    15601 tatccagggc ggccccgagg gagccagctg cactcgcacc acctctgcac ccgacctggt
    15661 gatgtccgtg cgcgaactgg ggtcggcata cctgggtggc atctccctga cccaactcgc
    15721 ccgcgccgga cgcatcgagg agatgcgcac cggcgcgctg gacgcggcct gcagggcatt
    15781 tcgcactgat ccgcttccgt tctgctcctt gatgttctga gcccgttctt cccgccgttc
    15841 acaccgattg acgaggtgac cgcagtgccc ggccccggat atgctttcta cgaccaagaa
    15901 gaagaacgca gtgtcctcgc cgtacttcag gcattactga acagcaggga cacctacggc
    15961 aaaccacaac tgatttcgca ggctcgcagc ttcgaggaag ccgccggcga gcgattgaac
    16021 agcccgtatt gcctgtctct gaacagcggt acttctgcgt tgctcgccgg gctggcggct
    16081 ctcggaatcg gccccggcga cgaggtcatc gttccgggat tcatgttcat cgccacgatc
    16141 agcactgtcg tccacagcgg agccaccccg gtcttcgcgg agatcgacac gtcactcacg
    16201 ctcgatcccc aggacgtccg acgcaagatc accgaacgga cgcgtgcgat cgtcgcggta
    16261 cacatgctcg gcgcgtcctg cgacatggcc gcgctgtccc aaatcgccga ggaaaacggc
    16321 ctgtacctca tcgaggacgt cgcacaggca tgcggtggca cctaccgcgg agcgccgctc
    16381 gggacactcg gcgacgtcgg cgccttttca ctggacacct tcaaggtgat caacggcggc
    16441 ggtgccggag gattcctgct gatgaaagac ggacgactgt tccagcgggc ttactcgttc
    16501 catgatcagg gctggttccc cggccgggag gaaaccggag acggcgacgt gatcttcggg
    16561 ttgaacttgc ggatgcctga attcaatgcc gcgttcgcgc gtgctcagct cgccaagctc
    16621 gacaccgtgc ttgagcgcac ccggctcgtg aaaagccagc tcgacaagct catcccgctc
    16681 aggcccggcc tggagcaacg tcgcctgaac gaccccgacg gcgactgcgc gacggtctca
    16741 gtctacctgt tcgaccagcc ggaagccgcg caagcggtcg cccaagaact cggctgctcg
    16801 accctggaca agtcgcggcg acactactac gcccaaatca acgcactctc gcccccgccg
    16861 gaccaggagg ctcccacttg cccgttccag cataagccgg gagagaagcg ccgaaacaca
    16921 ctggcaccgg gagagctgcc gaggaccgac aatctgctca gtcgcgccgt cgccctttcc
    16981 gtcgggctct cggacagtta ccttggctca gggttcggcg cctccgtccg cagtgatccc
    17041 gacgaattgt ctggcatcgc ggaccggttc tccgccgcgg cggcgcaagc gctcaggtga
    17101 agggcctgaa agcctgcccg cgcttctcac cgacctctga taaacggaag gttttcttgt
    17161 gacgtcgtca gaacaagaac tcattgacaa ggcggtacgc gacgcgatct actaccccgt
    17221 atccgatcag tccatgcagc ggggcgaggg aatctatctg tatgacctcg aggataaaga
    17281 gtacattgac tgcgcctccg ccacgttcaa tctcagcctg gggtacggac accctgcggt
    17341 cgtctccgcc atccagcagc aggcagcgga actgatccac gtcacctcga gtttccagtc
    17401 cgcaccgatc tccgacctcg tccgaaggct ggtcgagata tcgccgaaga acctcaccaa
    17461 agtgcacctg aaggtgtccg gcggctcgga agcgaacgaa ggcgccgtga agatggcgca
    17521 atacgctacc gggaaaaagg acgtcatcac actttttcgc agtcatctcg gccagaccat
    17581 gatgatggct tcgctgtccg gaaacgcatt ccgccggcag ccctttccgt tgacctaccc
    17641 tggcggactc cacgttcccg acccctactg cttccgctgc ttctacgggc agaccaggga
    17701 aacctgcggg ttgatgtgcg tcgaccgaat cgacgacttc atcgagttcg ccagcagcgg
    17761 gcgggtggca gcggtcatgg ttgagccggt ttccggcaac ggcggcaaca tcgttccccc
    17821 cgacggatat ttccagcagc tcaggaagtt ctgcgatgaa cgagatatcg cactgatctt
    17881 cgacgagatc cagaccggca tcggccgaac cggccagatg ttcgcggccc agcatttcga
    17941 cgtgcaacct gatgcgatca cggtaggcaa ggggctgggc ggagccggag cccaggtcgc
    18001 cggaattctc accaatgagc gactggcggg cctgcccggg aaccatcact cgttcaccta
    18061 cggcgcgaac ttgctcgccg ccgcggcagc caatgccacc gtcgacatca tcagacagcc
    18121 cgaattcctc gcgaacgtaa gatccgtcgg aaaccacatc ctggcgcgcc tggcggagct
    18181 caagaaaagc tacccggcca tcggggacgt gcgcggaata ggactcatgt tggggatgga
    18241 gatcattgag ccggacaaca gtccggcagt gaaggcgacc aatcatttgg ccgcggccgc
    18301 acagcgccat ggccttatta tccgaacttc aagatacggc tacggtaatg tcctgaagat
    18361 ccggccgccg ctgatcatga cacatgacga agcagacatt gtctgcgacc gtctcgagat
    18421 gctgttcagg gaggaattcg cgtgaaaaat cttattgtag gcctcgcgca ggctatccgc
    18481 acagaagtgc tcgcccgcag gccggtcggt gccgggcggt ccgtgctgca cgactccccc
    18541 ggcggagacg cccagttcga catcgacgag gtcgccgaag aggcgatctg gcgctatctg
    18601 aagagtgaat gcggcgaccc catcgcggta tacaccgagg accacggcct gcggaacctc
    18661 ggacgcaatc cgcgccacct gctggtgatc gatcccatcg acggtacgcg cccggcctca
    18721 gcggggctgg agatggcgaa cgtgtccatc gcctcggccc cgatgtccga agacccgatt
    18781 atgtccgatg tggaccacgc gttgctaatg gagctgtcca ccggcagatg gatgtacgcg
    18841 gatgcgaaca gcccggaatt gacgaccgaa gggtacatcc agcagattcc gtgcctgagc
    18901 gccaatgacg atcttgcacg catgttctgg tcgatcgaat tcaacggtca tcccatgcac
    18961 ctgatgaaca ccgcatacgg acatctggtt aaccagtccg cgaacaccgg aggcgtgttc
    19021 gtcttcaaca gcgcttcatt ctcgatctcc cggttgatca ccggacagct cgatgcctat
    19081 gtcgacatcg gcaatcgcat cctccgcgac cgtccggaga cgcgcgaaga gttcctcgcg
    19141 gcaggccgcg gtaatattct gcacctgttt ccgtacgaca tcgccgccag cgtgctgctc
    19201 gctgagcgca gcggcgtgac catcaccgac gcttatggag aaccgctcgg caagacccgg
    19261 ctgctcgacc tcgcgccgac gaaccagcag tcatgtatcg ccgcggcgaa ccctcggctg
    19321 cacgagcgac tgctggactc gatcgagtgg tcatccgatg acaatggcat tgtgaggtga
    19381 tgtggcgatg aaagcgttgg cattgacaga agaccagacc ttgcagcttg tcgaccgccc
    19441 ggatccgatc gcgtccggcc cccgtgatgt ggtggtcaag gttacccaga ccggcatctg
    19501 cggcaccgac cggagcgttc tggtcgggaa gttccgggcc gcgccgggga cgatcatggg
    19561 gcacgaggcg atcggcgtcg tcgcggagac cgggcccgcg gtcaccggcc tgcgcgtggg
    19621 cgatcgagtc gtggtgaatc cgactctcta ctgcggccga tgcgactact gtctccgcgg
    19681 caagcgcaac cattgcctca acaaggcagg caccgaggta gggatcgacc gagacggctc
    19741 gtatgcggaa tacatcgtct tggaggatct gttccttcat ctgattccgt ctgacacgag
    19801 cgacgaccgt gcggtgctga tcgagccgct cgcctgcgtg ctcaataaca tcgacgccgc
    19861 gcggatgact ccggccagca cggttaccgt actcggcggt ggtccgatcg ggctgctgtg
    19921 cgttctcgtc ctcgctcatt tcggccaccc ggtgaccttg gtcgagcagg acacctatcg
    19981 ccggagtttc gccacgacgt tcctcgacgg cgttccggag aactcggtcc ggatcgtggg
    20041 agcggacgag ctcggccagc tgcccgggac cgacgtggtg atcgacaccg tcggcggatt
    20101 gctggacaag gcgctggcgc acgtgtcggc gggcggcctg gtggtgatca tgggcttcga
    20161 cagccgggcc gcggtcacag tcaggcctct cgagatcctg cagcgaggca tctcgatcgt
    20221 cggtgccggc gacttccagc cggaagtgtt tccccgagcc atcgatctgg cacgccgtct
    20281 gcctctggag cggctgatca cccaccgatt cccgcttgaa cgacatgacg aagcgttcca
    20341 ggcgctggcg ggcacagtcg gccgaagtgc gaactattcc gcacagaagg tagtgatcca
    20401 gtcaagttcg ccggccaacg atgcgcactg accggaaacg actggccgac gtcatcgcgg
    20461 tgcccggacg gccggtcgcg atcctggccg actatccgta ttaccgagcc gatccgggca
    20521 actggccggg caatctcaaa accctgcgat ctctcggcgt cgatgtcatc acggcctacg
    20581 taccgtggcg attgcacgag gtcgagacca gccaggggca taggcgttac gacttcgacg
    20641 gaagtactca gccgcacgcc gacctgatcc gatttctccg gctcgtggac gaggcggacc
    20701 tgctggccat cctcaagcca ggccccttca ttcacggcga ggtcgacttc ggcggactgc
    20761 ccgaccggct cgataccgga aaaatgaccg cgacggcgaa ctgggccgga gccgtgcgga
    20821 ccagcgaggg ccacccgctg ccatcggctt tcgatccgcg cttccaggag gaggtccgca
    20881 cctggctgaa cgcggttcgc gatcaggtgc tcctcgctca cacgcgtccg cacggacccg
    20941 tggtggcagc ccagctgggc aacgagggcc tatacggcga gactgcggag gcgatgaccg
    21001 actgcgactt ctccgatgcg gcgcgatgcg gcaccggttc ggccgtcgac tggccgcctg
    21061 cctcgccgag ctcccgcgcc aagtgggcga ggtcgatcag cagcgcgttg cgcgaccggc
    21121 tgacggagtt tcgcgatgcg ctgggcgact gtgttccgac cgtagtcaac ctgccgctcc
    21181 ccgacatcgg cggaacgcga cgagagctgg aggcctggct gtgccgggtg gtgcgaatcg
    21241 tcccggacag aacattgcca gggcacaaca cagtctggac aggcaatctg attcgctccg
    21301 aaagcgtttt gtccgcttac tggttcgggg tgcgggcgat cgatgccgac accatggagg
    21361 acaactgggg attcacctgg acggacccct cttacgcgac accagccgta ccggctcact
    21421 acagccttct cgacctcgcg ctcgggtcga ccacgctcag cgtatacacg gcctgcgcca
    21481 ccaggaattg gccgccagtc atcgcaccgg acgagtcagt gctcggcgac agcagccacc
    21541 tgtacgcgcc cccgtactgc agcggcgctc cggtcgacga atcaggaaac atcaggccaa
    21601 atgctagagc actgcgtctg ctgagccagt tcctcgactg gcacggcacc gcgctgcgca
    21661 agacacgggc gagcaccaca gccagtctcc tggtcgatcc ggtgaccgta gctgccgacg
    21721 cctggccgga cgaggacgac cagccgggaa gggcgctgcg gacggccgtc gaggggtgca
    21781 cccgatggat gatgcgaagc ggtcaggacg tcgacgtcac cgtcggccgg attcctctcg
    21841 actccggctc tcgccggaac ccgatcatcg tcgcaggcgg ccgtggaatg accgcggcgc
    21901 ttcaggaagg cctcgccgtc gagatccggt ccggtcgtcc tgtcgtgttt gtcggcgagc
    21961 tgccgaccct cgacgaacac gacaatgagt gcgtgctgct ccgtactgcg ttagaaagcc
    22021 ctgacgccgt cgcgcgggta ttcgatccca gcggcgaatc cccggcacac acgttgcacg
    22081 aagtgctgcg gcacatcgcg gaggatcgtc cggcagcgcc tggcgtgctg cggcttgtcc
    22141 ggtcggacga ccagaccggc tcggagttca cgtttctgtt caacaggaac gaaactcggc
    22201 aactcgccac cggaacgcgc cgttcagtcg acttctcgat cgagctcgag ccctggtcgt
    22261 ccacggcact cgtctggacg gggaaggcct tgacaggctt cgtcgtcgcc gccggggccg
    22321 attcttcctc cggcgagcag ctcaggccga tgcgagtcgg agacgaaacg ttcggcggcc
    22381 cgaacatcgg agacgcggta ggccgtcgcg ctggctcggg atgggagatc ctgaccttct
    22441 ccgatcatta gcagtgcccg ccgcggccct taccgaacag gtgaatacct catgcctgcc
    22501 gtcaaagaag attcatgtga ttccatcgca gcccagtacg tcgaatacat cgcactcgcc
    22561 ttggacccgg ctacccggac gatcagcgcg acatcgtggg agcacagtgc ggagtactac
    22621 cgctgggcga ccgagaaact tgtttcgatc acaaaaacct cgccggaaat acaaaactcc
    22681 tacaacgccc tccgtgcctc cccgacggac ccagaaccat atttcgcgct cagaaactcc
    22741 ttagctttgc atctcgccgc atctccagcg atccgagccg aaatcagcca gcatctcgat
    22801 caatctctcg cccgcaacga aatcggctac catgtgggaa cctcgtatcg acgggacgtc
    22861 gctgccgtgc actccgacat gctgcaagcc aaatgcgagg agacgatacg ccgcgaaccg
    22921 ccccgctcgg aggtcgacgt tcagattatt atcccgtttc gggacagcga gaactcgggc
    22981 cggctgcgga acctgttagc cctgcttctc gcgttgcaag accaatcgat gccacgccac
    23041 cgctatgcca ccaccgtggt cgaggccgac gagatcccgc gctggaagcc agctttgaca
    23101 ccattcgtcg atcactatct attcgcatgc aaatccggaa aattcaacaa gtcgtggaca
    23161 gtaaacaccg gcgtcgtcaa caccgaggtc aaaccgaagt tcctgtgcat tctcgacgcc
    23221 gatatgctcc ctgaccggca cttcctcgca cgaaacgctg ccagactgag ccaggtcgac
    23281 aactcggcac acctcccgta tcaccgcggc ggtctgttgt cccttgacgc gcccgctagc
    23341 aatgcctcga tcaaggaaag gtgtttccgg gcggagcccg aagtcgacct gtcattgctg
    23401 cgcggccacg tgctgctggc cgcgccgggc ggatcagtat ggacccatac cagcctgttc
    23461 catcgcatcg gcgggttcga cgagcggtac gaaggctggg gcggcgaaga cgacgacttt
    23521 gtcgaccgac tgaccgaagc cgggacattt cgccgattct cagactatac gatgcacctg
    23581 catcacagcc gtcctcagat gagagcagcc ggccatcctt ttaattcatg gatacagccg
    23641 cacggctgga cctcaagaaa ccgctacgga caattgacca agttcctcca tggccaagaa
    23701 aaccagggcg acgacgcctg aaattatgag gagtaaaggc gtgtatgacg ttatcattgt
    23761 cggtgcgcgc tgcgcgggat caccgttggc aatgctactc gcgcgcaatg gacttcacgt
    23821 actgctggta gacaaggccg agttcccgag cgacacatta tcgacgcacc ttctccaccc
    23881 tcccgccatc gacgcgctca ggcgctgggg cctgttcgcc gcgcttgaca gcgttggggc
    23941 tccccgcttg gacaagctgg tctggcgcta ccaagacatt gaagtcagcg gctttccatg
    24001 gaatccttac gacgtagacc acgtctatgc gccacgaagg tacgcattcg acctcatgct
    24061 tctcgaggaa gccatcaaag ccggtgccga gttccgcagc agattcgtcg tcgatgactt
    24121 ggtggtatcc agatcagggt cggtcgtcgg cgtccaggga cacggaccgc gaggacaacg
    24181 cactatcgaa cgggccagct tggtgatcgg cgcggacggc gtgcggtcgg tggtagcgaa
    24241 taaagtcggt gccgccacgc ttcgcgaaga cccgggcaag acctgctcct actacagtta
    24301 ctgggccgac ctcgacaaaa gcgaaatcga gatgtggccg ggattctgga ccggctacgg
    24361 catacttccc accaacaacg gactcactac ggtttccgtc ggcttcccaa ggtcgagatt
    24421 cgatgaggtg cggaaagacg cgatc
//
