LOCUS       NZ_CP091381            22040 bp    DNA     circular CON 18-AUG-2024
DEFINITION  Amycolatopsis sp. FU40 chromosome, complete genome.
ACCESSION   NZ_CP091381
VERSION     NZ_CP091381.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. FU40
  ORGANISM  Amycolatopsis sp. FU40
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 9944196)
  AUTHORS   Reisman,B.J. and Bachmann,B.O.
  TITLE     Biosynthesis of Apoptolidin Family Glycomacrolides
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9944196)
  AUTHORS   Reisman,B.J. and Bachmann,B.O.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-2022) Chemistry, Vanderbilt University, 1234
            Stevenson Center Drive; Room 7330, Nashville, TN 37235, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 23-JAN-2022
            Assembly Method                   :: Flye v. 2.9
            Assembly Name                     :: NFU40_flye_2.9
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 47.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_021903635.1-RS_2024_08_18
            Annotation Date                   :: 08/18/2024 04:30:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,491
            CDSs (total)                      :: 9,417
            Genes (coding)                    :: 9,360
            CDSs (with protein)               :: 9,360
            Genes (RNA)                       :: 74
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 7 of 57
            Pseudo Genes (incomplete)         :: 50 of 57
            Pseudo Genes (internal stop)      :: 5 of 57
            Pseudo Genes (multiple problems)  :: 5 of 57
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:13:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3266149
            Orig. end                         :: 3288189
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP091381.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Brian O. Bachmann,
            Vanderbilt University.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22040
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="17"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22040
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22040
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12040](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12040
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     misc_feature    127..141
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.76"
                     /tool="antismash"
     gene            complement(742..2202)
                     /locus_tag="L3Q65_RS15940"
                     /old_locus_tag="L3Q65_15940"
     CDS             complement(742..2202)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012948310.1"
                     /locus_tag="L3Q65_RS15940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_15940"
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_237600129.1"
                     /sec_met_domain="Aldedh (E-value: 2.5e-142, bitscore:
                     473.7, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLLGTGWQGRIFSGGWIPGAGGEYDAVEPATGNTLARVGAAAPE
                     DVAKAAATAKEAQREWAAQPYDQRARVLRRAARLFEDHGDEIEEWLIRESGATRGFAQF
                     QTRAVAAEECHEAAALAAHPYGELLRSSQPRLSMARRVPAGVVGVISPFNAPVILSIRA
                     IAPALALGNAVLAKPDPRTAVCGGVVLARIFEEAGLPEGLFHLLPGGADVGAALVEDPL
                     VRVIAFTGSTNAGRRIAAAAGERLKRVHLELGGNSALVVLADADVEQAASVGAFGSFNH
                     SGQICMATGRHLVAAEIADDYAAALAEHAAKLTVGDPANGDVALGPLIDAGQRDRVHSV
                     VTGSAAAGAKIAAGGTYEDLFYRPTVLTDVPLAAPAYAQEVFGPVAPVVPFSTVDEAVR
                     LAGGTEYGLSLGILTRDAARGLALAERIPSGLVHVNDQTVNDEALAPFGGVGDSGTGSR
                     HGGAQANLEAFTETQWVTVRGDLPQYPF"
     gene            complement(2199..3815)
                     /locus_tag="L3Q65_RS15945"
                     /old_locus_tag="L3Q65_15945"
     CDS             complement(2199..3815)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009079169.1"
                     /locus_tag="L3Q65_RS15945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_15945"
                     /product="thiamine pyrophosphate-dependent enzyme"
                     /protein_id="WP_237600130.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1e-33, bitscore:
                     115.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2e-24, bitscore:
                     85.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPAPTVRDAAFDVLRRFGATTLFANPGSTEIALLTDLPDDLEFV
                     LALHEGSVVGMATGWALANDRPAVAILHTTAGLGNAVGALATARVNRAPLVVLVGQQDR
                     RHLALEPFLTGHRLDDLARPTPVWIAEPPRPQDVPGALARAWHEAREHRGPALVIVPMD
                     DWSEPAGADEPLPAPAKLVRANAAEPAVLAELAEFLGTASNPVLVAGAGADDAESWRGL
                     TALAERLACPVWQEAFGARAGFPQDHPQFAGHLPPGREGLRKALSGHDAVLSVGAPVFR
                     QYPREPGQLTEPDTRIAVVTDDPDEAHRSPVDLAVLARPSAVCGPLAELIPAREAGTEK
                     IGRTVELPGAPAPGAPLAPDHVFGLLARQLPKDTVLVEESPSSRPLLHAYVPAREPLGF
                     LSAAMGGLGFGIPAAVGLRMGGLKRPVVAVIGDGSSLYSIQSLWSAAHYGVGVLVIVLS
                     NGGYAIMDKLAVRHGERTAGGGKAPWPGFDEVSVSGLAKSLGCPARRAQTYEELESVLN
                     EVLPTLAARTEPLVLEVAVTA"
     gene            complement(3911..4612)
                     /locus_tag="L3Q65_RS15950"
                     /old_locus_tag="L3Q65_15950"
     CDS             complement(3911..4612)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020669599.1"
                     /locus_tag="L3Q65_RS15950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_15950"
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_237600131.1"
                     /transl_table=11
                     /translation="MLDSFLSGRPEQTHGEITRATGLAPATVHRLLAELTGWGALERTG
                     RGRYRIGLRLWQLGAQAPGGRELRDVALPFLQDLLQVTHEVVHLVVLDGDRALYLEKLE
                     AHPDVVVTSRVGLRLPLHAAGPGKVLLAHAPPECLEKILSGGLERRASGTITDPARLRQ
                     VLAEIRLQGFCISRNEMTEGASSVAAPVRGPGDQVVAAISVVVPSCTPNLSPLVPVVRM
                     AALGVTRALQG"
     gene            complement(4776..5927)
                     /locus_tag="L3Q65_RS15955"
                     /old_locus_tag="L3Q65_15955"
     CDS             complement(4776..5927)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="L3Q65_RS15955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_15955"
                     /product="MFS transporter"
                     /protein_id="WP_237600132.1"
                     /transl_table=11
                     /translation="MVILAVGTFVLGVDGFVLPGLLSDISRDLSVSVAAAGQLTTVFAV
                     AYAVGSPVIATLAGRADRRVVLGAGMGAFLVGMVLQAAGPSFGIVAAGRVVAALGAAAF
                     QANAFAVAGVLAAPERRARAFAVIGAGPSLAAVLGVPFGLLIGQVWGWRGTLWTIVVLA
                     AVAAVLAGVFVPSMTLPATTMRERLAVLVNPRIVMLLAVSALVLAPSFLLMAYAAAVVG
                     VSAPGSADAILVALLVNGAGFFLGNRLVGWVAERVASLRVIVAGLGAVAVAAGSLPVVQ
                     QWFGPTLVALFVLGVLGSMLFIPQQSRVFAAGGDVAAVALSLNGSMNYVGTAIGAGIGG
                     VVLANGGAGWLGPAAAILAAVVLAVALGAAPERRAARPAGAVR"
     misc_feature    complement(5964..5984)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 22.71"
                     /tool="antismash"
     gene            6020..6361
                     /locus_tag="L3Q65_RS15960"
                     /old_locus_tag="L3Q65_15960"
     CDS             6020..6361
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013229087.1"
                     /locus_tag="L3Q65_RS15960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_15960"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_182888873.1"
                     /transl_table=11
                     /translation="MPRTLPEPSVESFDLTVILSALADPGRRTLLKTMYQAGDPIDCAA
                     LVEKADLGLSNPTISHHYRVLREAGLTRTVAEGRHRIVHVRRDEVEARFPGLLEAILTA
                     PERTPPPHG"
     gene            complement(6733..9513)
                     /locus_tag="L3Q65_RS15965"
                     /old_locus_tag="L3Q65_15965"
     CDS             complement(6733..9513)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009079175.1"
                     /locus_tag="L3Q65_RS15965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_15965"
                     /product="glycoside hydrolase family 2 TIM barrel-domain
                     containing protein"
                     /protein_id="WP_237600133.1"
                     /transl_table=11
                     /translation="MTQVNRRRFLSGGIAVAGGGVLGAFGVSGTAEAAPDARPPQVGGG
                     EIGSGWTFVAADGTAADGSVLASAQNVAGLKPAVVPGTPLTSMIANGEYPDPLYGRIVT
                     DTVPDSLKDTGYWYRVAFRVPRLVPGQRFWLQFDGINYLGTVWLNGTRVGTVEGAFKRA
                     VFEVTDIVAEADGVAWLAVLVGKLDYADPPALPSYASGVTRGGRNGGPTGITLKNGPTF
                     FCTAGWDWLPTVPDRDLGIWQPVTWRTTGPVRVADVQVASTLSQDLRTAEVAVSLALDS
                     AAGESVVVTGSLDGQGFRRTVSVPAGASSVVLTSKEIACLRVDRPKLWWPNGYGEPYRY
                     RLAVGVESGGQVHDERTVDFGIRRIEYTTPMRSPSGTVSQCLAITVNNQPILVMGGNWG
                     LDEALKRIPRDRVRAQVRLHRDANLNLIRNWNGQSSTEDFFAACDEYGILVWQDFFCST
                     EGPPAENVARDLANIRDCIVRFRNHPSILLWCGGNEGPPPQPLIDGLDALVAELDPQRV
                     VLTSSAGDTGKNPVDGYRSGGPYHWVPPAQHFSLNDGTQWPPFRNEVGSYSIPTLEFMR
                     KMLPEASWEHPDDFWADRDVNGNGGNGGGAGYLRLTAERYGEVRNLADFARKSQLMNYE
                     CIRAIYEAPVAHMRSAGPYPRTGVIMWMTNPAQPSFVWQMYSHDLEAHSAFYAVQHACR
                     RVNVVLDARTFDVVVANHSREAVRGRVDVSLYGLDGAEFGRASFPVEGVGPADRGVVGS
                     VASALKGAPAEVAFVRLVLRDLRGLEVVRSFSWVESPGREAGFAGLDEMPAAAVSVIAG
                     VSRGPDGGEVVVDVRNIGESVALMLHLQVYDVRTGERVLPATFSDNYVNVVGGESVSVR
                     ARLDSDQVRRHPRVGVRVDGWKIDERASRLRGRGVAVTFNRDALDVSPAVPEFGR"
     misc_feature    9770..9789
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: medium, score: 25.72"
                     /tool="antismash"
     gene            9824..9919
                     /gene="pqqA"
                     /locus_tag="L3Q65_RS15970"
                     /old_locus_tag="L3Q65_15970"
     CDS             9824..9919
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033797.1"
                     /locus_tag="L3Q65_RS15970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_15970"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_037358081.1"
                     /transl_table=11
                     /translation="MPEPVEMWTAPDFVEYETPMEVTAYAARREE"
     misc_feature    9962..9973
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.48"
                     /tool="antismash"
     gene            10001..10699
                     /gene="pqqC"
                     /locus_tag="L3Q65_RS15975"
                     /old_locus_tag="L3Q65_15975"
     CDS             10001..10699
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020658743.1"
                     /locus_tag="L3Q65_RS15975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_15975"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_182888871.1"
                     /sec_met_domain="TIGR02111 (E-value: 2.4e-83, bitscore:
                     278.2, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTVHPMSPAEFTGALRGLQHRYWGSHPFHQRMHAGELTAQELRL
                     WAANRWYYQCVLPRKDAAIISNCPIPEIRRIWLDRIVYHDGAVEGEGGAERWLRLCAAV
                     GLDRAEVLDERHVAPGVRFAVDAYVAFARTKPWVEAVASGLTEMFAGHLMQQRVADVLA
                     NYSWISRADLAYFTNRIDKVSGEGKDTLDIVVQHCVTREQQEKAVSALSFKCDVLWSML
                     DAIERAAAKE"
     gene            10704..10976
                     /gene="pqqD"
                     /locus_tag="L3Q65_RS15980"
                     /old_locus_tag="L3Q65_15980"
     CDS             10704..10976
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009079179.1"
                     /locus_tag="L3Q65_RS15980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_15980"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_237600134.1"
                     /sec_met_domain="PqqD_RRE (E-value: 3.9e-22, bitscore:
                     76.9, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.2e-09, bitscore: 37.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTITAASVPKLRVGVRLTFDRVRGAHVLLFPEGVLLPNSTATAV
                     LELCDGTTPVSGIVTALSSRYQGVQESDVLAVLARFGQRRVIEWT"
     aSDomain        10710..10967
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_L3Q65_RS15980_PqqD_RRE.1"
                     /evalue="1.20E-24"
                     /identifier="RREFam006.1"
                     /label="L3Q65_RS15980"
                     /locus_tag="L3Q65_RS15980"
                     /protein_end="88"
                     /protein_start="2"
                     /score="76.9"
                     /tool="antismash"
                     /translation="TITAASVPKLRVGVRLTFDRVRGAHVLLFPEGVLLPNSTATAVLE
                     LCDGTTPVSGIVTALSSRYQGVQESDVLAVLARFGQRRVIE"
     gene            10967..12040
                     /gene="pqqE"
                     /locus_tag="L3Q65_RS15985"
                     /old_locus_tag="L3Q65_15985"
     CDS             10967..12040
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009079180.1"
                     /locus_tag="L3Q65_RS15985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_15985"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_237600135.1"
                     /sec_met_domain="PF04055 (E-value: 2.6e-21, bitscore: 75.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.2e-10, bitscore:
                     40.6, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 5.7e-11, bitscore: 41.8,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVAAPLGLLAELTHRCPLHCPYCSNPVELVARSAEMSTAEWTGA
                     LSQARELGVLQVHLSGGEPLARPDLPHLVTHASDLGCYVNLVTSGLGLTEPRLTDLVER
                     GLAHVQLSAQAATPERANLLAGAKAFDRKLAAAELVKASGLPLTVNVVLHRQNHDQLAE
                     IISLAESMGADRLELANTQYYGWALRNRDALMPTRAQLAAAEPIVRAAVERLRGTMEII
                     YVIADYYEPFPKPCMHGWGARQLTIAPDGTVLPCPAASAITTLELDNVRDTALADIWYR
                     SESFNAYRGEDWMRDPCRTCDRRTADFGGCRCQAFQLTGDAANADPVCSRSPHRGTVDL
                     VLAAPSASDLVMRGPAR"
     gene            12037..12897
                     /gene="pqqB"
                     /locus_tag="L3Q65_RS15990"
                     /old_locus_tag="L3Q65_15990"
     CDS             12037..12897
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631257.1"
                     /locus_tag="L3Q65_RS15990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_15990"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_182888868.1"
                     /transl_table=11
                     /translation="MKVILLGTAAGGGFPQWNCACSQCTSDSPPRTQDSVAFSADGRTW
                     HLLNASPDIRAQILATPALRAGPGPRETPLRTVLLTDAELDHALGLLMLREATALTVHA
                     PAAALHALTDRFPARSIVGEYHDWTWRPATETTLDGLHITSFPVSDKQPKYARASTQPG
                     PWVVAYRIHDPATGGTLVYAPCLRTWPSGFDGFTDGADLVLLDGTFYSATEFTTATESA
                     NPAAQQAMGHVPITTTLTTRPGTARWAYTHLNNTNPVVDPASPEHAAVLRAGAELPPDG
                     TEFTL"
     gene            complement(13285..13881)
                     /locus_tag="L3Q65_RS15995"
                     /old_locus_tag="L3Q65_15995"
     CDS             complement(13285..13881)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039462.3"
                     /locus_tag="L3Q65_RS15995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_15995"
                     /product="DUF6461 domain-containing protein"
                     /protein_id="WP_182888867.1"
                     /transl_table=11
                     /translation="MTNTLNHLAWLENNGPLQDIFCVSFVRRLDPPEVLRRFGADAGEQ
                     LAFAELNSRVAEYVGQTQGGNGGGHVGVVSCGEWSVAIEPFGWRGNLPEVIAGLSKESE
                     VVAVNRHDFAEAHFVHAVDGTVMTGFAPRMPSRRYGSEPDRLTPLMRESGLDPGQEERP
                     SHPIAAAFAVAAGMTGVVFTPEFLERTLLVGDIRT"
     misc_feature    complement(13926..13941)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.35"
                     /tool="antismash"
     gene            14227..15375
                     /locus_tag="L3Q65_RS16000"
                     /old_locus_tag="L3Q65_16000"
     CDS             14227..15375
                     /GO_function="GO:0015562 - efflux transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:1905887 - autoinducer AI-2 transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007034160.1"
                     /locus_tag="L3Q65_RS16000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_16000"
                     /product="AI-2E family transporter"
                     /protein_id="WP_237600136.1"
                     /transl_table=11
                     /translation="MRPPSAQHADHLAARTFRDIADRQTEGAQPPPAQPECEANGGSLP
                     RALVVLLGAAAATVVLAGVQAIAWFAAPVFLALVVVITLDPVRTWLRDKGFPRWLTVTV
                     LAIAVYAVLLVFFLVVVVSVAQLSALVPRYAGRFDELLRNGLATLGIGEAQVRGILSSV
                     DAGKLVRLTGSLLASAGKLVTNLAFLFGLLLFLSAETAWAGQRLSVIASDRPWISAALR
                     QFATDTRRYLLVTTVFGGIVASLDTAALALLGVPGALLWGLLSFVTNYIPNVGFVIGVA
                     PPAVIALLDHGWRGFLVVLLIYLVLNFAVQSLIQPRFVAGSVGLSTVVTVLALVFWTWL
                     LGPLGAVLAVPATLLAKALLVDVDPRARWADALLSAPRRDER"
     misc_feature    14497..14499
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(15383..17920)
                     /locus_tag="L3Q65_RS16005"
                     /old_locus_tag="L3Q65_16005"
     CDS             complement(15383..17920)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013225760.1"
                     /locus_tag="L3Q65_RS16005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_16005"
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_237600137.1"
                     /transl_table=11
                     /translation="MPDRTTTRSRPVPGAKVAVPRLPGIFVPRSRLDVLFRRAAVRPVT
                     VVRAPAGAGKTTALAAWAGVGRTVAWVSLDEDDNDETRLWEAILGALRRGAAEGGALHR
                     LRPPPPGRRRAFLADLDDALAGRTGPVRLILDDVQEIRAPEPLEALAALSRHLPPGLRL
                     VLATRVEPPLRLVRLQFEDVLSRVDAAELRFTAAETASLLRAAGASVDEERVRELTERT
                     AGWAAALGWTAVSVRDAEDSAVDSVTGDDRPVARFFADEVLAQLPAATTDLLLCLSICD
                     AVAATLAVRLSGLRDAGARLDELERAWGLVTRTPADTYRFFPLLRSFLRAELARRDPRR
                     VPRLHGIAARWHAAEGRFGEALRHAVAAQDREYLLALARDRAVRQVLAGDGQPVRAALD
                     CLGGATVAANPSLRLASALENIQGGRLAEAETDLCGEGAGDWWPLAVRHLAAVRGNRPA
                     GPSAARHPEFDAWAHLDRAWRSLYRGARRQARTQAQEALRLARGERLDHLVLHSRLAMA
                     VASAVGGKHPAMRRACTGALAVARRHDWQRTPGVAESRLLLAYDDLMRAEPAAAARELT
                     QATAAEVRGSAPLLVPLREFFEGMARFDDGDRTAGARLMRAARRQLAALELPRELAGVC
                     AVAEQHAALALGEALHATEVLAWTQEQLPGSGELALLRIRAHLSAGETAAAEALLRESA
                     SAAAVLPATPVDRCLAETALGLRSHRRTKALQALDQALALARPNGLVRPFALAEPPVRD
                     LLIGHSGGFGSLDRFAQTVRGRLVPHAPPSDLTDREQVVLQRLPSQRSLDEIASDLTVS
                     VNTVKTHVRAIYGKLGVNNRRSAVVVARQHGLT"
     gene            complement(17996..18457)
                     /locus_tag="L3Q65_RS16010"
                     /old_locus_tag="L3Q65_16010"
     CDS             complement(17996..18457)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013225759.1"
                     /locus_tag="L3Q65_RS16010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_16010"
                     /product="hypothetical protein"
                     /protein_id="WP_182888864.1"
                     /transl_table=11
                     /translation="MTERMHSPAGNAGTRPPLPPERAVARTRRTGWIWFAGAITVLAGL
                     FTAVEGLVALVDRHYYVVGPSGLLVFSLTGWGWLHLIVGVLAVLTGIALFAGAQWARVC
                     TVALAGFNALAQLAFLSAYPFWGAIVIALDVLVIWAVIVHGDEAAAEIW"
     gene            18652..19158
                     /locus_tag="L3Q65_RS16015"
                     /old_locus_tag="L3Q65_16015"
     CDS             18652..19158
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016331857.1"
                     /locus_tag="L3Q65_RS16015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_16015"
                     /product="DUF1269 domain-containing protein"
                     /protein_id="WP_182888863.1"
                     /transl_table=11
                     /translation="MATLTVWRFPTVDGAENALDLLQRLQKQQLISIADAARVSWPEGR
                     KKPKTKELGSLTGAGALGGTFWGLLFGLIFLVPLLGAAVGAAIGALTGSLRRVGIDEEF
                     IDTVRTQVTPGTSALFVLSDNAVLDRVAEPFRETGASLLTTNLSGEEEARLRAAFGEAP
                     EHEQL"
     gene            19446..20792
                     /locus_tag="L3Q65_RS16020"
                     /old_locus_tag="L3Q65_16020"
     CDS             19446..20792
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020420112.1"
                     /locus_tag="L3Q65_RS16020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_16020"
                     /product="DUF2252 domain-containing protein"
                     /protein_id="WP_182888862.1"
                     /transl_table=11
                     /translation="MPFTDKDTSARIARARAARIAVPAVCHAEFPSALQRADPLSLLAQ
                     QDSGRVPQLLPLRYTRLAASPLSYFHGTALSAAADLAATPRTGFAVQACGDAQLANFGL
                     FAAQGRKLVFDFADFDETLRAPWEWDVKRLAASFEVTAREIGHPAGQRRRTVLAAVESY
                     RLAMHEFARRTPLEIFFAPPDPRTLRTVAAHRLGPARRRASFRHTEIRDGRLKLAARAP
                     WAVAAGRLGGDGDPATLADRLCTVLRPYRRTLGAARRAMLDRYRLADAARAAPGPTSSG
                     ARCWVALLVRTDTGDPLLLQLKEARPSVLQEYTGTSALDSPGRRVVAGQRLIQAAGDVF
                     LGWARSPGFDGPARDFHVRGLRDDRGSGDVAAMTPDVLRANARLCGWTVAKAHARTGDA
                     LAIAAYLGSGPGFAEAVREFATACADQNERDHAALRRAIRAGRVAAAGS"
     gene            complement(20804..21076)
                     /locus_tag="L3Q65_RS16025"
                     /old_locus_tag="L3Q65_16025"
     CDS             complement(20804..21076)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020634067.1"
                     /locus_tag="L3Q65_RS16025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_16025"
                     /product="hypothetical protein"
                     /protein_id="WP_237600138.1"
                     /transl_table=11
                     /translation="MSAPAAPAPGARANYVFRGVGAIPGPAVESAADFPEVFAVPVPPE
                     TIVFAAVAGPGDLPRILRRLESLGMHVESVHRVRELPRTEHRAPA"
     gene            complement(21073..21393)
                     /locus_tag="L3Q65_RS16030"
                     /old_locus_tag="L3Q65_16030"
     CDS             complement(21073..21393)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020638945.1"
                     /locus_tag="L3Q65_RS16030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_16030"
                     /product="hypothetical protein"
                     /protein_id="WP_237600139.1"
                     /transl_table=11
                     /translation="MRGNSSEGRKRFGCTQLFWLGPGEVVAADLARTGSVSAGTAVLGL
                     TVVLAGLVSPARVRAGVRAAADLVARLVFLPPHGWSAFVVVLDLAVACFAWFTAGRDGG
                     RR"
ORIGIN
        1 gccccatgaa cgacgtcacc cagaacgcga tcgtcgcgcg gccgtagccg tgccggaaca
       61 ggacgcccag cggattgcgg ttccgccggg cttccttcgc ctgttccagc gccttcgact
      121 cgggcaggaa tttcatcatc agcggcacca ggatcagcgc gggcgcggcc ccgatgacga
      181 acatccactg ccagccgaac cgttgcagca ccaggattcc cagcagcgcg gtgagcaccg
      241 cgccgacgtg atagccggtc atcagcacgg tggtcgcgct gccgccgcgg ccgatccgcg
      301 cgtactcggt gatcagcgcc agcgccgtcg gcagcacccc gccgagcccg agcccggcca
      361 ggaaccgcag cacgccgaac agccacggcc cgttcgcgaa cgcgcagagc agcgtgcaga
      421 ccgagaagct gatcacggtc agcagcatca tcccgcggcg gccgaacagg tcgctgagcg
      481 ggccgatcgc gaacgcgccg accgccaccc cgagcagccc gatcgcggag atcagcgacg
      541 ccgtgttggg gtcgagcccc cacgctttgt ccttgagcag cgcgggcagc acgacgccca
      601 gcaccaccag gtcgaaccct tcgagcgcca ccgccgtcca gcacagcggg gccacccagc
      661 gggcgtggcg cgcccgggga tcagtcgaga ccgtcatgtc atcacctgcg tcgtcggagg
      721 ggacctggcc ggatactgcg gttaaaacgg gtactgcgga aggtcgccgc ggacggtgac
      781 ccactgggtt tcggtgaacg cctccaggtt ggcctgcgcg ccgccgtgcc gggagccggt
      841 tcccgaatcc cccaccccgc cgaacggggc gagggcttcg tcgttgaccg tctggtcgtt
      901 gacgtgcacc agaccggacg ggatccgctc ggcgagcgcc agcccccgcg cggcgtccct
      961 ggtcaggatg cccagcgaaa gcccgtactc ggtaccgccg gccaggcgca ctgcttcgtc
     1021 cactgtggaa aacggcacga ccggcgcgac cgggccgaac acctcctggg cgtaggcggg
     1081 cgcggcgagc gggacgtcgg tgaggacggt cgggcggtag aacaggtcct cgtaggtgcc
     1141 gccggcggcg atcttcgcgc ccgccgccgc gctgccggtg accaccgagt gcacgcggtc
     1201 gcgctgtccg gcgtcgatca gcgggccgag cgcgacgtcg ccgttcgccg ggtcgccgac
     1261 ggtcagcttg gccgcgtgct cggcgagcgc ggccgcgtag tcgtcggcga tttccgccgc
     1321 gaccaggtgc cgtccggtcg ccatgcagat ctgcccggag tggttgaacg aaccgaacgc
     1381 gccgaccgac gcggcctgct cgacgtccgc gtccgcgagc acgaccagcg ccgagttgcc
     1441 gccgagttcg aggtgcacgc gcttgagccg ctcccccgcc gccgcggcga tcctgcggcc
     1501 cgcgttcgtc gaaccggtga acgcgatcac gcgcaccagc gggtcctcga ccagcgccgc
     1561 accgacatcc gcgccgccgg gcaggaggtg gaacagacct tcgggcagac cggcttcctc
     1621 gaagatccgg gccagcacga cgccgccgca caccgccgtg cgcgggtcgg gcttcgcgag
     1681 aacagcgttg ccgagcgcca aggcgggtgc gatcgcgcgg atggagagga tcaccggcgc
     1741 gttgaacggc gagatcacgc cgaccactcc ggccgggacc cggcgcgcca tcgacagccg
     1801 gggctggctg gaacgcaaca gttccccgta cggatgcgcg gccagcgcgg cggcttcgtg
     1861 gcattcctcg gccgcgaccg cacgggtctg gaactgcgcg aacccccgcg tggcaccgga
     1921 ttcccggatg agccattcct cgatctcgtc gccgtggtct tcgaaaagcc gcgctgcgcg
     1981 acgcagcacc cgcgcccgct ggtcatacgg ctgagcggcc cactcccgct gtgcttcctt
     2041 cgcggtggcc gcggctttcg cgacatcctc cggagccgcc gcgccgaccc gggcgagcgt
     2101 attgccggtc gctggctcga ccgcgtcgta ctctccgccc gcgccgggga tccagccgcc
     2161 ggagaaaatc cggccctgcc agccggttcc gagcaacgtc atgccgtcac cgccacttcg
     2221 agcaccagcg gctccgtgcg cgcggccaac gtcggcagca cctcgttcaa caccgactcc
     2281 agttcttcgt aggtttgcgc gcgccgcgcc gggcagccga gcgatttcgc gagcccgctc
     2341 acgctgacct cgtcgaatcc aggccacggc gctttcccgc ccccagccgt gcgttcgccg
     2401 tgccgcacgg cgagtttgtc catgatcgcg tagccgccgt tggacagcac gatcacgagg
     2461 acgccgactc cgtaatgcgc ggcgctccac agcgactgga tcgagtacag cgacgagccg
     2521 tccccgatca ccgccaccac cggccgcttc agtccgccca tccgcagtcc gaccgccgcc
     2581 ggaatgccga agcccagccc gcccatggcc gcgctgagga acccgagcgg ctcgcgcgcc
     2641 gggacgtacg cgtgcagcag cggacggctc gacggggatt cctcgaccag caccgtgtcc
     2701 ttgggcaact ggcgcgcgag cagaccgaac acgtggtccg gcgccagcgg cgcgcccggc
     2761 gccggggccc cgggcagctc gaccgtccgg ccgatcttct ccgtgcccgc ttcccgcgcc
     2821 ggaatcagct ccgccaacgg accgcacacc gccgacggcc gcgccagcac cgcgaggtcg
     2881 accgggctgc ggtgcgcttc gtccggatcg tcggtgacca ccgcgatgcg ggtgtccggc
     2941 tcggtcagct gtcccggttc ccgcgggtac tggcggaaaa ccggtgcgcc gaccgagagc
     3001 accgcgtcgt gcccggacaa cgctttccgc agtccttccc ggcccggcgg cagatgtccg
     3061 gcgaactgcg ggtgatcctg cgggaatccg gcgcgcgccc cgaacgcttc ctgccacacc
     3121 gggcaggcga gcctctccgc cagcgcggtc agcccgcgcc acgattcggc gtcgtcggcc
     3181 ccggcgcccg ccacgagcac cggattgctt gcggtaccga ggaattccgc cagttcggcc
     3241 agcaccgcgg gctcggcggc gttcgcgcgg accagcttgg ccggggcggg cagcggctcg
     3301 tccgcgcccg ctggttcgga ccagtcgtcc atcggcacga tcaccagcgc cggtccgcgg
     3361 tgctcgcgcg cctcgtgcca ggcgcgggcg agcgcacccg gaacgtcctg cgggcgcggc
     3421 ggttccgcga tccacaccgg cgtcggccgg gcgaggtcgt cgagccggtg gccggtcagg
     3481 aacggctcga gcgcgaggtg gcggcggtcc tgctgcccca cgagcacgac cagcggcgcg
     3541 cggttgaccc gggcggtcgc cagggcgccg accgcgttcc cgagccccgc ggtggtgtgc
     3601 aggatcgcga ccgcgggccg gtcgttcgcg agcgcccagc cggtcgccat gccgaccacc
     3661 gaaccctcgt gcagcgccag cacgaactcg aggtcgtcgg gcaggtcggt gagcagcgcg
     3721 atctcggtcg acccggggtt ggcgaacagc gtcgtggcgc cgaaccggcg cagcacgtcg
     3781 aacgcggcgt cgcgaacggt cggggcaggg ctcacggact tctcctcggc agtgcggcag
     3841 cgggcggtcc ggagtctccc ggctcgcctc cgggccgccc agcccctctt ccactcagcg
     3901 gaaaagttcc tcagccttgc aatgcccgcg tgacccccag cgcggccatc cggaccaccg
     3961 gcaccagcgg cgacagattc ggcgtgcaac tgggcaccac cacggaaatc gccgccacga
     4021 cctgatcgcc cggcccgcgc accggagccg cgaccgacga cgcgccctcg gtcatctcgt
     4081 tgcgggagat gcagaaccct tgcagccgga tctccgccag cacctgccgc agccgcgccg
     4141 ggtcggtgat cgtcccgctg gcccgccgct ccagcccgcc ggacagaatc ttttcgaggc
     4201 attccggcgg cgcgtgcgcg agcagcacct tgcccggccc cgccgcgtgc agcggaagcc
     4261 gcagcccgac gcgcgaggtc accacgacat ccggatgcgc ctcgagcttt tccagataca
     4321 gcgcgcggtc cccgtccagc acgaccaggt ggacgacctc gtgcgtcacc tgcagcagat
     4381 cctgcagaaa cggcagcgcg acgtcccgca gctcgcgccc gcccggagcc tgcgccccga
     4441 gctgccacag ccgcagcccg atccggtacc ggcctctgcc ggtgcgctcg agcgcgcccc
     4501 agccggtcaa ttcggcgagc agccggtgca ccgtggcagg cgcgagcccg gtcgcccggg
     4561 tgatctcgcc gtgagtctgc tcgggtcggc cggacaggaa ggaatccagc accgcgaacg
     4621 cgcggctcag gaccgtgcgc ccgggttcgg cggcgttgcc ggcgatcgcg tgcctccggg
     4681 gctgcggtgg aacgggacgg ggactggccg cccatcatcc gccagtcccg cggacacggc
     4741 aacccgcctt ccccccgacc gtccacactg gacgctcacc gcaccgcgcc cgccggcctc
     4801 gccgcccgcc gctccggcgc ggcgcccagc gcgaccgcca gcaccaccgc cgccaggatc
     4861 gccgccgcag gccccagcca cccggctccg ccgttcgcca gcaccacgcc gccgatcccc
     4921 gccccgatcg cggtcccgac gtagttcatc gacccgttga ggctcagcgc gaccgccgcg
     4981 acgtccccgc ccgccgcgaa cacccggctc tgctgcggga tgaacagcat cgaccccagc
     5041 acccccagca cgaacaacgc cacgagcgtc ggcccgaacc actgctgaac gaccggcaac
     5101 gaacccgcgg ccaccgccac ggcccccagc cccgccacga tcacccgcaa cgacgcgacc
     5161 cgctccgcga cccacccgac gagccggttg ccgaggaaga accccgcccc gttgaccagc
     5221 aacgccacca gaatcgcgtc cgcactgccc ggtgcgctca cccccaccac cgcggccgcg
     5281 tacgccatca gcaagaacga cggcgccaac accagcgcac tgaccgcgag caacatgacg
     5341 atccgcggat tgaccagtac cgccagccgt tcgcgcatcg tcgtcgcggg caacgtcatc
     5401 gacggaacga acaccccggc cagcaccgcc gcgaccgccg ccagcaccac aatcgtccac
     5461 aacgtgccgc gccaccccca gacctgcccg atcagcagac cgaacggcac cccgagcacc
     5521 gccgcgagac tcggccccgc cccgatcacc gcgaacgccc gcgccctccg ctcgggcgcg
     5581 gcaagcactc cggcgaccgc gaacgcgttg gcctgaaacg cagccgcccc cagcgccgcg
     5641 acgacccgcc ccgccgccac gatgccgaag gagggccccg ccgcctgcaa caccatgccg
     5701 acgagaaacg cccccatccc cgccccgagc acgacccggc ggtccgcccg ccccgcgagc
     5761 gtcgcgatca ccggcgaccc caccgcatac gcgaccgcga agaccgtcgt gagctgcccc
     5821 gccgccgcga cgctcaccga cagatcccgc gagatgtccg aaagcagccc aggaagcacg
     5881 aacccgtcca ccccgagcac gaacgtgccc acggccagga tcaccatgcg cacaccgttc
     5941 gatgattgtc gaatcgtcac atcgatggag cctaaactat gattcgacga cggtcaaagc
     6001 attgattgga gccccgccag tgccgcgcac gctgcccgag ccgtccgtcg aatcgttcga
     6061 cctgacggtg atcctcagcg ccctagccga tccaggcagg cggacgctgc tgaagacgat
     6121 gtaccaagcc ggggatccga tcgactgcgc ggcactggtg gagaaagcgg acctgggcct
     6181 cagcaacccg acgatctcgc accactaccg ggtcctccgg gaggccggcc tgacccgcac
     6241 cgtcgccgaa ggccgccacc ggatcgtcca tgtgcggcgc gacgaggtgg aggcgcggtt
     6301 ccctggactg ctggaggcaa tcctcaccgc tcccgaacgc acgcctcccc cgcacggctg
     6361 acgcgccgct ccccggtctg tccacatcgg acgctggtgc cgccgcccgt gaggggcccc
     6421 ttcacgacca gcaccccact acgcgatgcg ctcatgcggt gttcggcgca tcccacgcac
     6481 ccaatgcggc attgggtgca tgcgacgcac ccaatgccac attggggcgc tagcgccgcc
     6541 ccgcgaaccg cagccgatgc acccggcatt cgaggcgccc aaccgcaccg atgcacccac
     6601 ccatggaggc accccgcacc gcccccaacc ccgatccgaa gccgccctgc gaaccgtcag
     6661 cacaataaaa cttcgggggt gggggccacc gcaccagcgc aatgtcgccc gccagggcga
     6721 cgagccgacc cctcaccgcc caaactcggg caccgcagga ctcacgtcca acgcgtcccg
     6781 attgaacgtc accgccaccc cgcgcccccg caaccgagac gcccgctcgt cgatcttcca
     6841 cccgtcgacc cgaaccccga cccggggatg ccgccgaacc tgatcgctgt ccaaccgagc
     6901 ccggacactc accgattccc cgccgaccac attcacataa ttatcactaa acgtagcggg
     6961 aagaaccctt tccccggtcc gaacgtcata aacctgcaaa tgcagcatca acgccacaga
     7021 ctcaccgata ttccgcacat cgaccacgac ctcgccccca tccggccccc gggaaacccc
     7081 ggcgatcacc gaaaccgcgg ccgcgggcat ctcgtccagg ccggcgaacc cggcctcccg
     7141 cccaggactc tccacccacg agaaactccg aacaacctcc agcccccgaa gatcccgcaa
     7201 caccagccgg acaaaagcaa cttcggcagg cgcccctttc aacgccgaag caacgctccc
     7261 caccacaccg cgatcagccg ggccaacccc ctccaccgga aacgaggcac gaccgaattc
     7321 cgccccgtcc agcccgtaga gcgagacgtc gaccctcccc cgaaccgcct cccgcgaatg
     7381 gttcgccacc accacatcga aagtccgcgc gtccagcacc acattcaccc gccggcaagc
     7441 atgctgaacc gcgtagaacg ccgaatgcgc ctccaaatcg tggctgtaca tctgccaaac
     7501 gaaactaggc tgcgcaggat tggtcatcca cataatgacc ccagttcgcg gataaggccc
     7561 agcactccgc atatgcgcca ctggcgcctc gtaaatcgcc ctgatgcact cgtaattcat
     7621 caactgcgac ttgcgcgcga aatccgcgag gttccgcacc tccccgtacc gctcggcagt
     7681 cagccggagg tacccggccc cgcccccgtt ccctccgttg ccgttgacat cccgatcagc
     7741 ccagaagtcg tccggatgct cccacgaagc ctccggcagc atcttccgca tgaactccag
     7801 cgtcggaatc gaataagacc cgacctcgtt gcgaaacggc ggccactggg taccgtcgtt
     7861 caacgagaag tgctgggcag gcggcaccca gtgatacggc ccgccggacc ggtacccgtc
     7921 aaccggattc ttcccggtgt ccccggcaga actggtcagc accacccgct gcgggtccag
     7981 ctcggcgacc agcgcgtcca ggccgtcgat caacggctgc ggaggcggcc cctcgttccc
     8041 gccgcaccac agcaggatcg aggggtggtt gcggaaccgc acgatgcaat cgcggatgtt
     8101 cgcgaggtcc cgtgcgacgt tctccgcggg cggcccttcg gtcgagcaga agaagtcctg
     8161 ccagaccagg atgccgtact cgtcgcaggc ggcgaagaag tcctcggtac tgctctgccc
     8221 gttccaattc cggatcaaat tgagattggc gtcccggtgc aatcgaacct gcgcacgcac
     8281 cctgtcccgg ggaatccgct tcagcgcctc gtccagcccc cagttcccgc ccatcaccag
     8341 aatcggctga ttgttgaccg taatagccag acactggctc accgtcccgg agggcgaccg
     8401 catcggcgtc gtgtactcga tccgccggat cccgaagtcc acggtccgtt cgtcgtgcac
     8461 ctggccgccg gactcgaccc cgaccgccaa ccggtaccga taaggttccc cgtacccatt
     8521 gggccaccac aacttcggcc gatccacccg cagacaggcg atctccttcg acgtcagcac
     8581 caccgacgac gccccggccg gaacactgac cgtccgccgg aacccctgcc cgtcgaggga
     8641 ccccgtcacc accacggact ccccggcagc gctgtccaac gcaagcgaga ccgcgacctc
     8701 cgccgtccgc aaatcctgcg acagcgtcga ggcgacctgc acgtcagcca cccggaccgg
     8761 cccggtggta cgccacgtga ccggctgcca gatccccaga tcccggtccg gaacggtagg
     8821 cagccagtcc cacccagcgg tgcagaagaa cgtcggcccg ttcttcagcg tgatcccggt
     8881 cgggccgcca ttgcgcccgc ctcgcgtcac cccgctggcg taactcggca acgcgggcgg
     8941 atcggcgtag tcgagcttcc cgaccagcac cgccagccag gcgacgccgt ccgcctcggc
     9001 cacgatgtcg gtgacctcga agaccgcgcg cttgaacgcg ccttcgaccg tcccgaccct
     9061 ggtcccgttg agccagacgg tcccgaggta gttgattccg tcgaactgca gccagaaccg
     9121 ctggcctgga accagccgcg gcacccggaa cgcgacccgg taccagtagc cggtgtcctt
     9181 gaggctgtcc ggaacggtgt ccgtcacgat gcggccgtac aacggatcgg gatactcgcc
     9241 gttggcgatc atgctcgtca gcggagttcc cggaaccacg gcgggcttca gccccgcgac
     9301 gttctgcgca ctggccagca cgctcccgtc cgcagccgtg ccgtcggccg cgacaaaggt
     9361 ccagccgctg ccgatctcgc cgccgccgac ctgaggcgga cgtgcgtccg gagccgcctc
     9421 ggcggtgccg gacaccccga acgcgccgag cacaccaccg cccgcgacag caatcccgcc
     9481 ggacagaaac cgcctgcgat tcacctgggt cacgtcgctc ccaaagcctc tgacatcgtt
     9541 gtcaaccgca ctcgaaccct attattcggc cgcccgccgt cccgatgtca agcggcgtca
     9601 ggaggtttcc gcgcccccgc acggtttctg tcgggcggac aaccggcagc ggcgcccctg
     9661 cgtgaccgtc cgctgcgcca taggaaggaa cctttataaa gtcggcggga aatcgccccg
     9721 cacccctggc gaccggccgc cttgcgcttt tagggtgacg gcgttcgggg cggggacgac
     9781 tgccccgctc accggtgcac caccgaagga aagcgagttt cccatgcccg agcccgtcga
     9841 gatgtggacc gcgcccgact tcgtcgagta cgaaacgccg atggaggtca ctgcctacgc
     9901 ggcccgccgg gaggaatgac ccgccggacg gggccggtcc gccgcggtcc cgtccgttcc
     9961 ggaaaacctt accgctgagc gagaatcccg gaggacgcga atgtccactg tgcacccgat
    10021 gagtccggcg gagttcaccg gagcgctgcg cggcctccag caccggtact ggggcagcca
    10081 tccgttccac cagcgcatgc acgccggcga actgaccgcg caggaattgc ggctctgggc
    10141 cgcgaaccgc tggtactacc aatgcgtgct gccgcggaaa gacgcggcca tcatcagcaa
    10201 ttgcccgatc ccggaaatcc gccggatctg gctcgaccgc atcgtctacc acgacggcgc
    10261 cgtggagggc gaaggcggag ccgaacgctg gctgcggctg tgcgccgccg ttggtctgga
    10321 ccgcgccgaa gtcctcgacg agcggcacgt cgctccgggc gtccggttcg ccgtcgacgc
    10381 ctacgtcgcc ttcgcgcgta ccaagccctg ggtggaagcc gtcgcctccg gcctgaccga
    10441 gatgttcgcc gggcacctga tgcagcagcg cgtggccgac gtcctggcga actattcgtg
    10501 gatttcccgt gccgacctgg cgtacttcac caaccggatc gacaaggtct ccggagaggg
    10561 caaggacact ttggacatcg tcgtgcagca ctgcgtcacc cgcgaacagc aggagaaggc
    10621 agtgtccgcg ctgtcgttca agtgcgatgt cctgtggtcg atgctcgacg ccatcgaacg
    10681 cgccgccgcc aaggagtgag ccgatggaca ccatcaccgc cgcgtcggtg ccgaaactgc
    10741 gcgtcggcgt gcgcctgacg ttcgatcgcg tgcgcggggc gcacgtgctg ttgttcccgg
    10801 aaggcgtgct gctgccgaac tcgacagcca ccgcggtcct ggaactctgc gacggcacca
    10861 ccccggtctc cggcatcgtc accgcattga gcagccggta ccaaggcgtc caagaaagcg
    10921 acgtcctggc cgtgctggcc cggttcggac aacggcgggt gatcgaatgg acgtagccgc
    10981 gccgctcgga ttgctcgccg aactgaccca ccgctgtccc ctgcactgcc cgtactgctc
    11041 gaatcccgtg gaactcgtgg cccgatccgc ggaaatgtcc accgctgaat ggaccggcgc
    11101 gctgtcccaa gcccgggaac tgggcgtgct ccaggtccac ctctccggtg gagaaccatt
    11161 ggcccgcccg gatcttccgc acctggtcac gcacgcgagc gacctcggct gctacgtcaa
    11221 cctggtcacc tccggcctgg gcctgaccga gccccggctg accgatctcg tcgaacgggg
    11281 tctcgcgcac gtccagctct ccgcccaagc cgccacccca gagcgggcga acctgctcgc
    11341 cggagcgaaa gccttcgacc gaaaactggc cgccgccgag ctggtgaaag cctccggcct
    11401 gccgctgacc gtcaacgtgg tgctgcaccg gcaaaaccac gaccagctgg ccgaaatcat
    11461 ctccctcgcc gagtcgatgg gcgcggaccg gctcgaactg gccaacaccc agtactacgg
    11521 ctgggccctg cgcaaccgcg acgcactgat gcccacccgc gcgcagctcg ccgccgcgga
    11581 acccatagtc cgcgcggccg tcgaacgcct ccgcggcacg atggagatca tctacgtcat
    11641 cgccgactac tatgagccgt tccccaaacc gtgcatgcac ggctggggcg cgcggcaact
    11701 caccatcgcg cccgacggca ccgtcctgcc ctgccccgcc gccagcgcga tcaccacgct
    11761 cgagctcgac aacgtccgtg acaccgcctt ggccgacatc tggtaccgct cggagtcctt
    11821 caacgcctac cgcggcgaag actggatgcg cgacccgtgc cgcacctgcg accggcgtac
    11881 cgcggacttc ggcggctgcc gctgccaggc gttccagctc accggcgacg cggcgaacgc
    11941 cgaccccgtg tgctcccgct cgccacaccg cggcacagtc gacctcgtcc tcgccgcacc
    12001 gtccgcttcg gacctggtta tgcgtggccc ggcccgatga aggtcatcct cctgggcacc
    12061 gcagcaggcg gcggatttcc ccagtggaat tgcgcctgct cgcaatgcac ttcggactct
    12121 ccgccacgta cgcaggacag cgtcgccttc agcgcggacg gccgcacctg gcatctcctc
    12181 aatgcctcgc ccgacatccg cgcgcaaatc ctggcgaccc cagcactgcg tgccggacca
    12241 ggcccgcgcg aaacgccgct gcgcacagtc ctgctcaccg acgccgaact agaccacgcc
    12301 ctcggtctgc tcatgctccg cgaggcgacg gccctgaccg tccacgcccc cgccgccgcc
    12361 ctgcacgcgc tgaccgaccg cttcccggcc cgctccatcg tcggcgagta ccacgactgg
    12421 acctggcgcc ccgccaccga gaccaccctc gacggcctgc acatcacctc ctttcccgtc
    12481 agcgacaaac agccgaagta cgcccgcgcc tccacccagc ccggcccgtg ggtcgtcgcg
    12541 taccgcatcc acgacccggc aaccggcggc acgctcgtct acgcgccctg cctgcgcacc
    12601 tggccatccg gcttcgacgg tttcaccgac ggcgcagacc tcgtcctcct ggacggcacc
    12661 ttctacagcg ccaccgaatt cacgacggcc accgagagcg ccaacccggc cgcccagcag
    12721 gcgatgggcc acgtgccgat caccacgacg ctcaccaccc gcccaggcac cgcccgctgg
    12781 gcttacacgc atctgaacaa cacgaacccg gtcgtggacc cggccagtcc ggaacacgcc
    12841 gccgtgctgc gtgccggagc ggaactgccg ccggacggaa ccgagttcac gctctgaccg
    12901 aagcactcaa gcacgcacgc cggatcagtg gtcgcggcaa gaaccgctat gtgtcaaaag
    12961 cttcgcctcc ggcgactccg gggaggtgaa gagccatcac gtccgtcccg acggctggag
    13021 cgttttccag ctgcccagga cgtttgcacc gcccgactcc gcgcagccgc tgccgtcccg
    13081 gccgccgttc cgcgactgac ctcggcgagc acggccaagc cgcctccggc ctgtcctggc
    13141 gcaccgcacg gcacagccgt acccggcccg gagaaccggg acttcccatc ggccgcctcc
    13201 cgccaccaca ccgcctcctt accgccaccg acagcactgc cttcgacaac cttccctccc
    13261 ggcgcccgcc ggaactccgc gccgctaagt ccggatatcc cccaccagca acgtccgctc
    13321 caggaactcc ggcgtgaaca ccactccggt catcccggcc gccactgcga acgccgccgc
    13381 gatcggatgc gacggtcgtt cctcctgccc cggatccaac ccggactcgc gcatcaacgg
    13441 cgtcaaccga tccggctcgc tcccgtaccg ccggctcggc atccgcgggg cgaagcccgt
    13501 catcactgtg ccgtccaccg cgtggacgaa atgcgcttcg gcgaagtcgt gccggttgac
    13561 cgccacgact tcgctttcct tcgacagtcc ggcaatgact tccggcaggt tcccgcgcca
    13621 cccgaacggc tcgatcgcca cgctccactc cccgcacgag accacgccga catggccgcc
    13681 gccgtttccg ccttgggttt gcccgacgta ctccgctacc cggctgttca gctccgcgaa
    13741 cgccagctgt tcgccagcgt ccgcaccgaa gcgccgcaag acctcgggcg ggtcgagcct
    13801 gcgcacgaac gaaacgcaga agatgtcctg cagcgggccg ttgttctcca gccaggcaag
    13861 gtggttcagg gtattcgtca tcgtgtcctc ctcagtcggt ccaggccatg gtggcaggcg
    13921 ccaccgacaa aaaatcgccg agcatccggc aaccccgccc ccttcgggtg aagaccggcc
    13981 tcgcgttcgc cgccactatc ggattccgcc gcctgcctcc ggaggattcg catggtgcga
    14041 gcgcagttca ccgacttccc ggcccgccgg ttccgcaagc accggcacgc acatcgcctg
    14101 gcacgccgca ccttccggca cttcgccgac cggcgaggcg agggcgggcg aacgcctttc
    14161 gcccaacgcg cgaatcaccg ggaaagccgc acctcccgag actccgccga tcaacggagc
    14221 gaaggtgtgc gaccaccgtc cgcccaacac gcggaccacc tggccgcccg cactttccga
    14281 gacatcgccg atcggcaaac cgagggcgca caaccgccac cggcccagcc cgagtgcgaa
    14341 gcgaacggcg gctcgctccc ccgcgctctc gtcgtcctgc tcggggccgc cgccgcgacg
    14401 gtcgtgctcg ccggggtgca agccatcgcc tggttcgcgg caccggtgtt tctcgccctg
    14461 gtcgtcgtga tcaccctcga cccagtgcga acctggttac gcgacaaagg attcccccgc
    14521 tggctgacgg tcaccgtgct cgccatcgcc gtctacgccg tcctcctggt cttcttcctc
    14581 gtcgtcgtgg tttccgtcgc acagttgtcc gcgctggtgc cgcgctacgc cggacggttc
    14641 gacgaattgc tgcgcaacgg gctggccacg ctcggcatcg gcgaagcaca ggtccgcggc
    14701 atactgtcct ctgtcgacgc gggaaaactc gtccggctga ccggttcgct gctcgcgagc
    14761 gcgggcaagc tggtcacgaa cctcgcgttc ctgttcgggc tcttgctgtt tctgagcgca
    14821 gagacagcct gggcggggca acggctcagc gtgatcgcta gcgaccggcc gtggatttcc
    14881 gcggcgttgc gccagttcgc cacggacacg cggcgatacc tgttggtgac gacggtgttc
    14941 ggcggaatag tagcgtcgct cgacaccgcc gcgctggcgc tgctcggcgt tccgggggcg
    15001 ttgctgtggg ggctgctttc cttcgtcacc aactacattc ccaacgtcgg cttcgtgatc
    15061 ggagtggccc cgcccgcggt gatcgcactg ctcgaccacg gctggcgcgg cttcctcgtg
    15121 gtgctcctga tctacctcgt cctcaacttc gcggtgcaat ccctgatcca gccgcggttc
    15181 gtggccggtt cggtcgggct gtccactgtg gtcaccgtgc tggcgctggt gttctggacc
    15241 tggctgctcg gcccgctcgg ggcggtgctc gcggtgccgg cgacgctgct ggccaaggcc
    15301 ctgctggtgg acgtcgaccc gcgggcccgg tgggcggacg cgctgctgtc ggccccgcgc
    15361 cgcgacgagc gctgaccggg catcaggtga ggccgtgctg ccgggcgacg acgacggcgg
    15421 agcgccggtt gttcacgccc agcttgccgt agatggcccg cacgtgggtt ttcaccgtgt
    15481 tgaccgagac ggtgagatcg gaggcgatct cgtccagcga acgttgcgaa ggcaggcgct
    15541 gcagcaccac ctgctcgcgg tcggtgaggt cgctgggcgg ggcgtgcggg acgagcctgc
    15601 cgcggaccgt ctgcgcgaag cggtcgagcg agccgaaccc gccggagtgg ccgatcagca
    15661 ggtcccggac cggcggttcg gcgagcgcga acggccgcac cagcccgttg ggccgggcga
    15721 gcgcgagggc ctggtcgagg gcttgcaggg ctttggtccg ccggtgcgaa cgcaggccga
    15781 gcgcggtttc ggccaggcag cggtcaacgg gagtggccgg cagcacggcg gccgccgacg
    15841 cggattcccg caggagggct tcagccgcgg cggtttcgcc ggcggagagg tgcgcgcgga
    15901 tccgtaggag agcgagctca ccgctgccag gaagctgctc ttgagtccag gcgaggactt
    15961 ccgtcgcgtg cagcgcctcc cccaacgcca gggctgcgtg ttgttcggcg accgcgcaca
    16021 ctccggctag ttcgcggggc agttccaaag cggcaagctg gcggcgtgcc gcgcgcatga
    16081 gtcgggcgcc cgccgtccgg tcgccgtcgt cgaagcgcgc cattccctcg aagaactcgc
    16141 gcaacggcac gagcagcggt gccgaaccgc gaacctccgc cgcggtcgcc tgggtcagtt
    16201 cccgtgccgc ggcagccggt tcagcgcgca tcaggtcgtc gtaggcgagc agcagacgag
    16261 actcggcgac ccccggcgtt cgctgccaat cgtgccggcg cgctaccgcg agggctccgg
    16321 tgcacgcccg gcgcattgcc ggatgcttgc cgccgacggc gctggcgacc gccattgcca
    16381 gtctgctgtg cagtacgagg tgatccagcc gctcgcctct ggccaggcgc agcgcttcct
    16441 gcgcctgcgt cctcgcctgc cggcgcgcgc cgcggtacag cgaacgccag gcgcgatcga
    16501 gatgggccca ggcgtcgaac tccggatggc gtgctgccga tggtccggcc gggcggtttc
    16561 cccgcacggc ggccaggtgc cggacagcga gcggccacca atcgcccgca ccctcgccgc
    16621 acagatcagt ctccgcttcg gcgagccgtc cgccttggat gttctcgagc gcggaggcca
    16681 accgcagcga cgggttcgcg gcgactgtcg caccgccgag gcagtccagc gcagcgcgta
    16741 ccggttgccc gtcgccggcc agcacctggc gcacggctcg gtcccgggcc agtgccagga
    16801 ggtattcccg gtcctgtgcc gcgaccgcgt gccggagcgc ctcgccgaac cggccttcgg
    16861 cggcatgcca ccgcgcggcg atcccgtgca gccgcggcac ccgccgcggg tctcgccgcg
    16921 cgagttcggc gcgcaggaaa ctccgcagga gcgggaagaa ccggtaggtg tcggccgggg
    16981 tgcgcgtgac cagtccccac gcccgctcca gttcgtccag tcgcgcgcca gcgtcccgga
    17041 ggccggacaa ccggaccgcg agggtcgccg cgaccgcgtc gcagatgctg aggcacaaca
    17101 acaaatcggt ggtggcggcg ggcagctgcg cgagcacttc gtcggcgaag aacctcgcca
    17161 ccggtcggtc gtcgccggtg acggagtcga cggcggagtc ttccgcgtcg cgcaccgaaa
    17221 ccgctgtcca gcctagtgcc gcggcccatc cagcggtgcg ttcggtgagc tcccggacgc
    17281 gctcctcgtc caccgaggca ccggcggctc gcagcaggct cgccgtttcc gcggcggtga
    17341 agcggagttc ggcggcgtct acccgggaca gcacgtcttc gaactgcagg cggaccagcc
    17401 ggagcggagg ctcgacccgg gtcgccagca ccagccgcag tccgggcggc aggtggcggg
    17461 acaaggcagc gagcgcctcc agcggttcgg gggcgcggat ttcctgcacg tcgtccagga
    17521 tcagccgaac cgggccggtc cggccggcca gcgcgtcgtc gagatcggcc aggaacgccc
    17581 gccgccgtcc gggcggcggc gggcgcaacc ggtgcagcgc accgccttcc gctgccccgc
    17641 gccgcaaggc cccgagaatc gcctcccaca accgggtttc gtcgttgtcg tcctcgtcga
    17701 gagacaccca ggcgaccgtg cggccgaccc cggcccaggc ggccagcgca gtggtcttgc
    17761 ccgccccggc cggggcccgg accacggtga ccgggcgcac ggcggctcgg cgaaacagca
    17821 cgtccagccg ggaacgcggg acgaagatcc ccggcagccg cggcaccgcg accttcgcgc
    17881 cggggaccgg ccgggaccgg gtcgtcgttc gatcgggcac gtcaaacctc tcggctgtcg
    17941 ggagatttcg cccccggctc cgggcggagg ccacgactgt actgagcgcc gccagtcacc
    18001 agatttcggc ggcggcctcg tccccgtgca cgatgacggc ccagatcacc aggacgtcca
    18061 aggcgatcac gatcgcgccc cagaacgggt acgcggacag gaacgccagc tgcgccagtg
    18121 cgttgaaccc ggcgagcgcg acggtgcaga cccgggccca ctgcgcgccg gcgaacagcg
    18181 cgatcccggt cagcacggcg aggacgccga cgatcaggtg cagccagccc cagccggtca
    18241 gggagaagac gagcaggccg gacgggccga cgacgtagta gtgccggtcg accagcgcga
    18301 ccaggccctc caccgcggtg aacagtccgg ccaggacggt gatcgcgccg gcgaaccaga
    18361 tccagccggt ccggcgcgtc ctggcgacgg cccgctccgg cgggagcggc ggccgggtcc
    18421 cggcgtttcc ggccggggag tgcatgcgtt cggtcatggt ctcttcctcg ttcgtcgacg
    18481 ggctgcggac ccgggcgatc atggtcggcc gccgcggcgg cgggcctcgc ccgactcagg
    18541 tgagatcagg ggccgcggcg gcgccaggct ttcacccggc gcgggcgagg acgcgcgccg
    18601 cggcacggga aacagtgcgg cggaccgctg atcccggaac gaggagaagt catggccacg
    18661 ttgaccgtgt ggaggttccc gaccgtcgac ggcgcggaaa acgcactgga tctgctccag
    18721 cggctgcaga agcagcagct gatctcgatc gccgacgcgg cgcgcgtgag ctggcccgag
    18781 ggccggaaga agccgaagac caaggaactc ggctcgctga ccggagcggg tgcgctcggc
    18841 gggacgttct ggggcctgtt gttcggcctg atcttcctcg tcccgctgct gggcgcggcc
    18901 gtcggcgcgg cgatcggcgc gctgaccggt tcgctgcgcc gcgtcgggat cgacgaggag
    18961 ttcatcgaca ccgtgcggac gcaggtcacc cccggcacgt ccgcgctgtt cgtcctgtcg
    19021 gacaacgccg tgctggaccg ggtcgccgag ccgttcaggg aaaccggggc ctcgttgctg
    19081 acgaccaatc tgtccggcga ggaggaagcc cggctgcgcg ccgcgttcgg cgaagctccg
    19141 gagcacgaac agctctagtc cgcagctgga cgggctctcg ccggacgatc cggcgagggc
    19201 ccgttcgcgt gccggtcgtc gtccgttcag tccagtccgg gcgaatgccg ttgcggcgca
    19261 agcgagaccg cggcgacgcc cccgaacgcc gccgcggcgc cccgcgcgag gcccggctgg
    19321 caccgcgacc tccgcgaccc atcctgcgga accggccgcg ttcggtcgtc acccgcctcg
    19381 gatgagctcg cttcacctcc ggcgggcgac gccgccgccc gctgccccgg ccgacgatcc
    19441 gtcccatgcc cttcaccgac aaggacacca gcgcacggat cgcccgcgcc cgtgccgcac
    19501 gcatcgccgt gccagccgtc tgccacgcgg aattcccgag cgccctccag cgtgccgacc
    19561 ccctgtccct gctggcgcag caggattccg gccgggtccc gcagctgctg ccgctgcgct
    19621 acacccggct ggccgcctcc ccgctctctt acttccacgg caccgcgctc tccgccgcgg
    19681 cggacctcgc tgccactccc cggaccggat tcgcggtcca ggcctgcgga gacgcccagc
    19741 tggcgaactt cggcctgttc gccgctcagg gccgcaagct ggtgttcgac ttcgccgatt
    19801 tcgacgagac cctgcgcgca ccctgggaat gggacgtcaa acgactggcc gcgagcttcg
    19861 aggtcaccgc ccgggagatc gggcatccgg ccgggcagcg caggcgcacg gtgctggccg
    19921 cggtcgagtc gtaccggctg gcgatgcacg agttcgcgcg ccgcaccccg ctcgagattt
    19981 tcttcgcccc gccggatccg aggacgctgc gcacagtcgc ggcccaccgg ctcggccccg
    20041 cgcggcgccg cgcctccttc cggcacaccg aaatccgcga cgggcgcctg aagctggccg
    20101 ctcgcgcacc gtgggcggtc gcggccgggc ggctcggcgg ggacggcgat ccggcgacgc
    20161 tcgcggaccg cctctgcacc gtcctccggc cttaccggcg cacgctcggc gccgcgcgac
    20221 gggccatgct ggaccgctac cggctcgccg atgcggcgcg cgccgcgccg gggccgacca
    20281 gctcgggcgc ccgatgctgg gtcgccctgc tcgtccggac ggacaccggc gacccgcttc
    20341 tccttcagct gaaggaagcc cggccgtcgg tgctgcagga gtacaccggg acctccgcgc
    20401 tcgacagtcc cggaaggcgg gtggtcgccg ggcaacggct gatccaggcc gcgggcgacg
    20461 tcttcctcgg ctgggcccgc tcccccggat tcgacggccc ggcccgcgac ttccacgtcc
    20521 gcgggctgcg cgacgaccgg ggttccggcg acgtcgcggc gatgaccccc gacgtcctgc
    20581 gggccaacgc ccggctgtgc ggatggacgg tggccaaggc gcacgcgcgc accggcgacg
    20641 ccctcgccat cgccgcgtac ctcggttccg ggccgggttt cgccgaagcc gtccgggaat
    20701 tcgcgacggc gtgcgcggac cagaacgaac gcgaccacgc cgcgctgcgg cgggcgatcc
    20761 gggccggccg cgtcgcggcg gccgggtcgt gacggaccgg gcttcacgcg ggcgcgcggt
    20821 gctccgtccg ggggagttcg cggacccggt ggacggattc gacgtgcatc ccgagcgatt
    20881 cgagcctccg caggattcgc ggaagatcgc cgggaccggc caccgcggcg aacacaatcg
    20941 tttccggcgg aacggggacc gcgaacacct cggggaaatc ggcggcgctt tcgaccgccg
    21001 gtccgggaat ggcgccgacg ccgcggaaaa cgtaattcgc gcgggcgccg ggagccgggg
    21061 cggcgggcgc gctcatcggc ggcccccgtc ccgtccggcc gtgaaccacg cgaagcaggc
    21121 caccgcgagg tcgaggacca ccacgaacgc cgaccagccg tgcggcggca ggaacaccag
    21181 ccgcgctacc aggtccgcgg cggcgcggac tcctgcccgg acccgggcgg gcgagaccag
    21241 cccggcgagc accacggtca gcccgagcac cgccgtcccg gcgctgaccg aacccgtccg
    21301 ggccaggtcg gccgccacga cctcgcccgg gccgagccag aacaactgcg tgcagccgaa
    21361 tcgcttccgc ccctccgagg aattcccgcg cattttcact cgccccacga ttctgccgcc
    21421 gggcgccgtt ttcctcgccc gcagcggatg agccgcgcgc attgcctggc aagatccgcc
    21481 ggaatcgccc ggaaccccct gagaaggaga atcgcgcatg cgccgacccc gcgccgtgtc
    21541 gccccgaaga caagtgccga ggacgaaagt cgccgttccg ggaccgcccg cggacctcgt
    21601 ttcccggccg cggctgctcg ccgtcctcga ccgcgtgcac gaagccggcc tcgtgttcgt
    21661 cggggctccc gccggtttcg gcaagaccgt gctgctcgcc gaatgggcgc gccgccgggg
    21721 ccgcggcgcg gtcgcctggc tggcggccga cgccgacgac aacgacgacc ggctcttctg
    21781 gtccgcggtc ctcgaagcgc tcgcccgcag cggccggttc gcggacggcg atccgttgcg
    21841 gttcctggcg gtgcccgagt cgccgagcac cgatctcgcg ttcctggccg aactcgccga
    21901 cgtgctcgac accttgccgg aacccctcgt gctcgtgctc gacagcgcgc acgagatcac
    21961 ctcgcccgaa ccgtggcgcg ggctgcggac gctggtgcgc caccagcccg cgggactgtg
    22021 cctcgcggtt tcgagcagac
//
