LOCUS       NZ_CP091381            20902 bp    DNA     circular CON 18-AUG-2024
DEFINITION  Amycolatopsis sp. FU40 chromosome, complete genome.
ACCESSION   NZ_CP091381
VERSION     NZ_CP091381.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. FU40
  ORGANISM  Amycolatopsis sp. FU40
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 9944196)
  AUTHORS   Reisman,B.J. and Bachmann,B.O.
  TITLE     Biosynthesis of Apoptolidin Family Glycomacrolides
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9944196)
  AUTHORS   Reisman,B.J. and Bachmann,B.O.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-2022) Chemistry, Vanderbilt University, 1234
            Stevenson Center Drive; Room 7330, Nashville, TN 37235, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 23-JAN-2022
            Assembly Method                   :: Flye v. 2.9
            Assembly Name                     :: NFU40_flye_2.9
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 47.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_021903635.1-RS_2024_08_18
            Annotation Date                   :: 08/18/2024 04:30:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,491
            CDSs (total)                      :: 9,417
            Genes (coding)                    :: 9,360
            CDSs (with protein)               :: 9,360
            Genes (RNA)                       :: 74
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 7 of 57
            Pseudo Genes (incomplete)         :: 50 of 57
            Pseudo Genes (internal stop)      :: 5 of 57
            Pseudo Genes (multiple problems)  :: 5 of 57
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:13:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2474729
            Orig. end                         :: 2495631
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP091381.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Brian O. Bachmann,
            Vanderbilt University.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20902
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="14"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20902
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20902
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10902](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10902)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(164..397)
                     /locus_tag="L3Q65_RS12315"
                     /old_locus_tag="L3Q65_12315"
     CDS             complement(164..397)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021378.4"
                     /locus_tag="L3Q65_RS12315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_12315"
                     /product="SHOCT domain-containing protein"
                     /protein_id="WP_237599691.1"
                     /transl_table=11
                     /translation="MMYWHYGSAAEWVGPVVMSIVAVALLAAIGVVTALLVRRPAGLGH
                     EADPATAILRQRFARGEIDQDEYDRRREALRH"
     gene            complement(413..1420)
                     /locus_tag="L3Q65_RS12320"
                     /old_locus_tag="L3Q65_12320"
     CDS             complement(413..1420)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020658939.1"
                     /locus_tag="L3Q65_RS12320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_12320"
                     /product="NAD(P)H nitroreductase"
                     /protein_id="WP_237599692.1"
                     /transl_table=11
                     /translation="MERGLPDDYTVTTAVGMAVRAPSVHNSQPWRFAVGHRSLHLYADP
                     SRQLTQTDPDGRDLMISCGAALHHARIAFAALGWRTEVRRLPNPAEPGHLASIELHRHE
                     PTLDEVALAAAIPRRRTDRRRHSSWRVPRGHLEAIAQAVADEGVVLRVAEDAERYYLAT
                     AIEEASLRHRHDPAYRIELAAWSGRHASPDGVPSRNTPLPDETPGALPGRQFPNPELPE
                     AAGAAGEDDETVLLVLSTASDDRMSRLRAGEATSAALLTATRFGLASCPLTEPLELPDV
                     RRTVEDKVTSGAFPQMVLRVGWAPANADPLPATPRREIDEVLQPLEAADTRQRS"
     gene            1653..3062
                     /locus_tag="L3Q65_RS12325"
                     /old_locus_tag="L3Q65_12325"
     CDS             1653..3062
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020659903.1"
                     /locus_tag="L3Q65_RS12325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_12325"
                     /product="amino acid permease"
                     /protein_id="WP_237599693.1"
                     /transl_table=11
                     /translation="MSKAHEADRETPAASRIRALGLTSATGLVAGSVIGTGVFTMPAVL
                     AGAGTSSLLVLGVVAAGAAVLAVLFGQLTKRAPDSDGGLYAYARREFGDFAGYLVGWCY
                     WVSAWAGNAAIVASWVLYVEALFGIEHPSVWADLGIALAGLWIPAAVNLAGVRQMAWFQ
                     NTTVVLKFLPLLFVGVVGWFFVSKANFGAFNASGGSLYTAIGIAAGVALFAFIGVEVAA
                     VTAKRVREPGRNVGRASVLGTAASAVVYLAVSAAVMGLVPHDVLVSSGTPFVPAFEAIL
                     PGGGWAGKLVAALAVVSGIGALNGWTLVTTEVSRAAAADGLFPRAFAWADRKDTAWFGI
                     VLAALLPSLLMVWRYTSGTGLAVFSFLVNLAVVTVAIPYVFSACAQLAYLVSRRRRVHG
                     LLLVRDLGITAAAVLFSLWVTFAAGYAAVYEAMLVLLAGLVLHALLKGRAAAGRQKAAA
                     EETGDRWPRAA"
     gene            3091..4305
                     /locus_tag="L3Q65_RS12330"
                     /old_locus_tag="L3Q65_12330"
     CDS             3091..4305
                     /EC_number="3.5.3.6"
                     /GO_function="GO:0016990 - arginine deiminase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006527 - arginine catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020659902.1"
                     /locus_tag="L3Q65_RS12330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_12330"
                     /product="arginine deiminase"
                     /protein_id="WP_237599694.1"
                     /transl_table=11
                     /translation="MNFAVASETGRLRQVILHRPGPELARLTPRNIHELLFDDVMWARK
                     AKEEHDVFAEALREQGVRVHYFDRLLAETLDDPDGRAFVLDRVCTPRTVGPALAPTLRK
                     LFDDLDSPSLAESLIGGVLKADLHPLRTSSLKWHMLRADDFLLPPLPNHLFPRDTSCWI
                     YGGVSINPMAKPARQRETLHARAIYRYHPMFAGAGFRTYFDGDEDCFPATVEGGDVHVL
                     GGGAVLVGMGERTTPMAVELLARELFGSGQANTVLAVELPRSHATMHLDTLMTMVDRAT
                     FVLCPYFDPKLRSWTVTPGPDALEIQRNDSLWESLGQALGVERVTVLSTDEDVRAAERE
                     QWDDGNNYLAVAPGVVIGYDRNVATNTMLRKHGVEVITVPGGELGRGRGGPRCMSCPIE
                     RDPAR"
     gene            4340..5335
                     /gene="argF"
                     /locus_tag="L3Q65_RS12335"
                     /old_locus_tag="L3Q65_12335"
     CDS             4340..5335
                     /EC_number="2.1.3.3"
                     /GO_function="GO:0004585 - ornithine carbamoyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0042450 - arginine biosynthetic process via
                     ornithine [Evidence IEA]"
                     /codon_start=1
                     /gene="argF"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1114: ornithine carbamoyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020659901.1"
                     /locus_tag="L3Q65_RS12335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_12335"
                     /product="ornithine carbamoyltransferase"
                     /protein_id="WP_182889457.1"
                     /transl_table=11
                     /translation="MNLQGRNLLKETDLTAAEFRSLVDLAARLRQEKRSGAPARRLAGR
                     NIALVFEKSSTRTRSGFEVAAHDEGAHITYLGPEESHLGHKESVKDTARVLGRVFDGIE
                     FRGSSQEAAETLGAYAGVPVWNGLTDTWHPTQMLADILTMRDHAPGSLDDVSYCYLGDG
                     RNNVANSLLVTGALLGLDVRVCAPEPLWPREEIRRIAAGLAGESGAKLLVSDDVAEAVR
                     GAGFLYTDVWLSMGEPEDAWGPRIEQLLPYQVNAKVLAETGNPAVKFLHCLPALHGRDT
                     EIGKRLGDRYGLDALEVTDEVFESAASVVFDQAENRMHTIKAVMVATVGA"
     gene            5332..6249
                     /locus_tag="L3Q65_RS12340"
                     /old_locus_tag="L3Q65_12340"
     CDS             5332..6249
                     /EC_number="2.7.2.2"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020421655.1"
                     /locus_tag="L3Q65_RS12340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_12340"
                     /product="carbamate kinase"
                     /protein_id="WP_182889456.1"
                     /transl_table=11
                     /translation="MRIVAALGGNALLERGEPAESDIQEHHVLAAAEALAAVAREHELV
                     LTHGNGPQVGLLALESERDPALRRPYPFDVLGAQTQGMIGYWLAQALQNATGRPAAGLV
                     SRTLVRADDPAFAVPAKFVGPVYDRATAERLAAERGWEVRPDGAAWRRVVPSPEPVELI
                     ELPFVKALMESGAIVVCGGGGGIPVAAASPGLRGVEAVVDKDLTAALIAREIGADALVL
                     LTDVEAVQDDYGTPRARPIRDVGSRELRSRDFPAGSMGPKVEAACRFVENGGKFAAIGR
                     LTAAAGLVAGTAGTIVRACGPGFS"
     gene            complement(6242..6985)
                     /locus_tag="L3Q65_RS12345"
                     /old_locus_tag="L3Q65_12345"
     CDS             complement(6242..6985)
                     /EC_number="3.4.-.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0070007 - glutamic-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020674135.1"
                     /locus_tag="L3Q65_RS12345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_12345"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_182889455.1"
                     /sec_met_domain="Abi (E-value: 8e-15, bitscore: 54.1,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTMSVSAVVPKLPEVTDLRRRALTVVPAVLLLAAATVLANRVLPG
                     WAYPVCGAVTAAVLLVLARFAGVRWAEIGFGRAHARRMLWFGLGGFAAVALGFGLAAAI
                     PSLRVLFHDGRIGSPGFGQLMWLALVRIPLGTVLVEEVAFRGVLPALLGAGERWRWWPV
                     LGASALFGLWHLLPSLALTQNAAVHQTVGGLPLAMVSVLAMAAAAGAGVFLCWWRYTGR
                     GLLAPMLVHLATNSGGLVLAWALVS"
     gene            7017..8111
                     /locus_tag="L3Q65_RS12350"
                     /old_locus_tag="L3Q65_12350"
     CDS             7017..8111
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020660041.1"
                     /locus_tag="L3Q65_RS12350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_12350"
                     /product="acyltransferase"
                     /protein_id="WP_182889454.1"
                     /transl_table=11
                     /translation="MTTMEREPYLDFLRAVSLVVVVLWHWAFTILHWTPTGPQPTNPLA
                     YFRGLWVLTWFLQVLPVFFYVGGSVHLASWERARARGQSRRSYVWLHVKELVAPAGMLV
                     LFWTTAGIVLAEAFGVRWIGGAVMLILSPLWFLAVYVGLLLLLPLMAWLHERFDILVLV
                     WLAGAALLIDVLRLRFGWDAVSWVNVAAVWGLAYQAGFFHRRIVAASRHVAGTLLWAGL
                     FALAGLVLSGLYPGSMVGVPGERMSNMSPPTFVIVALLAFQIGLCEMLRPAVERALAKP
                     RRQRATAVFTRYALPLFLFHTTGMALARAVVYFGFDRHLADDRAPDWIWWAERPLAILG
                     PLLFTVPLIALFRQRHAVHQAAHE"
     gene            complement(8177..9652)
                     /locus_tag="L3Q65_RS12355"
                     /old_locus_tag="L3Q65_12355"
     CDS             complement(8177..9652)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019351.4"
                     /locus_tag="L3Q65_RS12355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_12355"
                     /product="multicopper oxidase family protein"
                     /protein_id="WP_237599695.1"
                     /transl_table=11
                     /translation="MPINRRDLLKITVGAAATASAGDMVAGCDTSPSAPLPEGKADYTL
                     RIGSGLVELAPDAIFSTTTYNGQFPGPLLRFAEDRPAVVDVHNDTDVPEQVHWHGQQVP
                     ADVDGSAEEGTPFVPAHGMRRVSFTPGPAGFRFYHSHLIAGSDLAKGQYGGLVGPVYIE
                     PKLNPGAYDQGVFLVLKEFAPTFSRAGDMAADFLAGAPDPELKERGEKAMADSLGRGMP
                     RGYEVGYGAFSVNGRKLGQGEPIKVRAGQRMLLHVLNGSATEIRSLALPGHVFRVVALD
                     GNPVPAPARVPVLWIGTAERVSAVVEMNRPGVWVLGDLADSDRGAGMGIAVEYAGRTGP
                     PQWTAPGPFTWDYRTFARAGAAAAAPDQTIDLLVEKRNAAVGGFNAWTLNGQSYSTALN
                     QPVIPVQRGKRYRLRLRNATDDVHPVHLHRHTVEVAAVAGTPTAGLFKDVVMLGGYQKL
                     DLDFVADQPGLSLLHCHQQLHMDYGFMTLFNCT"
     misc_feature    complement(9642..9655)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 23.03"
                     /tool="antismash"
     gene            complement(10001..10405)
                     /locus_tag="L3Q65_RS47315"
     CDS             complement(10001..10405)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF040195.3"
                     /locus_tag="L3Q65_RS47315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_255751347.1"
                     /sec_met_domain="T1TS (E-value: 2.8e-27, bitscore: 95.2,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTADEYHHPAVHQLRMHANNVVCWANDIQSLPVEARQPGQFRNMV
                     TLYASQGRTLTEAVEATAGRVRAEIVAFSSLARPTRDWASPALAGYIEGMQDWMRGYQD
                     WYDHDTQRYATAHAEHDADDRTVVPSDWKP"
     gene            complement(10402..10902)
                     /locus_tag="L3Q65_RS47320"
     CDS             complement(10402..10902)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF040195.3"
                     /locus_tag="L3Q65_RS47320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_255751348.1"
                     /sec_met_domain="T1TS (E-value: 2.6e-30, bitscore: 105.3,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDDAAEFAAIEVPGFQVPWPGACHPEAAAVEQTMIGWGQDNGLIP
                     TADYRDRVARTRYSYLAARCYPRADTALLQIIADYFLWFFLTDDLFVDRVDTDTPDTLA
                     NLTAMIDVLDHDRSRACPVYGETAWLDVCRRLRARLSPEHFDRFATGMRLWASTAGLQA
                     AHP"
     misc_feature    10967..10980
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.35"
                     /tool="antismash"
     gene            complement(11230..13212)
                     /locus_tag="L3Q65_RS12365"
                     /old_locus_tag="L3Q65_12365"
     CDS             complement(11230..13212)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020639213.1"
                     /locus_tag="L3Q65_RS12365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_12365"
                     /product="APC family permease"
                     /protein_id="WP_220506734.1"
                     /transl_table=11
                     /translation="MSWLKRLVLGRPFRSDTLGETLLPKWLALPIFASDPLSSVAYATQ
                     EILLILSIGGLTYLVLAPWVGLAVAVLLSVVVVSYRQVVKAYPSGGGSYEVASRNLGSH
                     AGLVVAGALMVDYIMTVAVSVASGVDNIISAVPGLNGYRIALDIGFIVVLTAMNLRGLR
                     ESGRAFAAPTYLFVVAVLLMIAVGFSRTLAGHAPVAESAGYAIRPEQVGLTGFALIFLL
                     LRSFSSGCTALTGVEAISNGVPAFRKPKAVNAARTMTAMGVIAVVMFGGITALALIAKV
                     HIAENACDLAGFAGQCATDPQRTVISQIGAAVFGGDHAVLFYFLQATTALILILAANTA
                     FNGFPLLASILAKDRYLPRQLHTRGDRLAFSNGIIALALIAAVLIYAFDGSTTRLIQLY
                     ILGVFTSFTLCQAGMVRHWNRELAAGTGSRHAIQRSRAINALGATLTAIVLAVVLVTKF
                     THGAYLVVIAIPALYVMMRAVHRHYTHVREELLPDEESELLPSRVHAIVLVSTLHKPSQ
                     RAIAFARATRPDTLTAITVNVDDAETRELQRQWERRGIKIPLKVVESPYREITRPVVAY
                     VKNFARSSPRDVVCIYIPEYVVGRWWENILHNQSSLRLKGRLLFEPGVMVTSVPWQLRS
                     SRRRDLQRVRPLPGDLRRGVTARRS"
     misc_feature    complement(13312..13327)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.53"
                     /tool="antismash"
     gene            13370..13678
                     /locus_tag="L3Q65_RS12370"
                     /old_locus_tag="L3Q65_12370"
     CDS             13370..13678
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="L3Q65_RS12370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="L3Q65_12370"
                     /product="hypothetical protein"
                     /protein_id="WP_182889451.1"
                     /transl_table=11
                     /translation="MVDDRVVRILRRTGAAEVIDALLTGPACLSRLRRTVPRRTLERSV
                     RALAAEGALVRADAGSWDTGLRADTELRLTASGLAVAAVLSDWDVWVRVYEDYLRDR"
     gene            13838..15064
                     /locus_tag="L3Q65_RS12375"
                     /old_locus_tag="L3Q65_12375"
     CDS             13838..15064
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0006814 - sodium ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013227558.1"
                     /locus_tag="L3Q65_RS12375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_12375"
                     /product="sodium:proton antiporter"
                     /protein_id="WP_182889450.1"
                     /transl_table=11
                     /translation="MALVLAFGVVLLVSVSLSGVAARTVLSTALLFLLAGALLGDGGFG
                     LIHIAPRDPLVTSLADIALFTVLFTDGQRASVPALRENWRLSGRALGLGMPLTMVGIAV
                     PAHFLVGLDWPTSLLLGAILSPTDPVFAAAIVGRDDVPLRLRRLLNVESGLNDGLALPF
                     VLIFLATATHTSSDLGTVVFELVLGLVLGIAIPALVALAWRLRVLTAEPRLQALGPLAV
                     AVLLYAACHLTDANPYLAAFAAGSTLATVDKTAAEHFEPLGDLLSEITKFAALLVFGAL
                     ITPDRLSHLSVGAWVLAVLAIVLVRPAALALSLLRTPMSGRERATAAWFGPKGFASVVY
                     GLLALQSGIADSELVFDLVAVTIALSIVLHSSTDVPIARLLRIEPPDKLPTGRPASAGG
                     DRKEKGKKS"
     gene            15104..15550
                     /locus_tag="L3Q65_RS12380"
                     /old_locus_tag="L3Q65_12380"
     CDS             15104..15550
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020658941.1"
                     /locus_tag="L3Q65_RS12380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_12380"
                     /product="CBS domain-containing protein"
                     /protein_id="WP_182889449.1"
                     /transl_table=11
                     /translation="MRAAELAEEFPVVDLDSDALAAARLLAEHRLPGLVVTEASGCPHT
                     VLPASDVVQFLVPPYVRDDPSLAGVLSESMADRVADKLGGRTVRELLPGEPRELPRVDA
                     DDTIVEVAATMARLRCPLVAVMRDRTLLGVVSASRLLEHALTPR"
     misc_feature    complement(15120..15134)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.74"
                     /tool="antismash"
     gene            15567..16856
                     /locus_tag="L3Q65_RS12385"
                     /old_locus_tag="L3Q65_12385"
     CDS             15567..16856
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009078282.1"
                     /locus_tag="L3Q65_RS12385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_12385"
                     /product="ArsB/NhaD family transporter"
                     /protein_id="WP_237599696.1"
                     /transl_table=11
                     /translation="MSTVIAVVVFVVAYVFIATEKIPKMTAALAGAGVVLATGVSGSAD
                     AFFSEDTGVDWNVLFLLLGMMIIVGILRRTGVFEFVAIWAAKRAKGSPLRIMLLLVLIT
                     AVASAFLDNVTTVLLIAPVTLLVCDRLDISPVPFLIAEVLASNIGGTATLIGDPPNIII
                     GSRAGLAFNDFLLNLAPIVALELVVLGLVLPWLFRGSFTVDPQRVADVMALNEREAIRQ
                     PKLLIKSGAVLLLVFAGFVLHSVVHLDPSVVALLGAGLLVLLSGTPPKQYLDGVEWETL
                     LFFAGLFIMIGALVKTGVIDWLAKLAAGATGGNALLAVFLILGVSALLSGVIDNIPYVA
                     TMSPLVLALTHDIPDPAHSEALWWSLALGADFGGNMTAVGASANVVVLGLAARAGAPIS
                     FWEFTKKGAVVTVITVLVAAPYLWLRYFVF"
     misc_feature    15601..15615
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.91"
                     /tool="antismash"
     misc_feature    17216..17234
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.53"
                     /tool="antismash"
     misc_feature    complement(17219..17231)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 20.03"
                     /tool="antismash"
     gene            17234..19030
                     /locus_tag="L3Q65_RS12390"
                     /old_locus_tag="L3Q65_12390"
     CDS             17234..19030
                     /GO_component="GO:0034707 - chloride channel complex
                     [Evidence IEA]"
                     /GO_function="GO:0005247 - voltage-gated chloride channel
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020498111.1"
                     /locus_tag="L3Q65_RS12390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_12390"
                     /product="chloride channel protein"
                     /protein_id="WP_237599697.1"
                     /transl_table=11
                     /translation="MSSGESAGKRGLVVPVRQPVGRWVRESRAGLVGLAVLIGAGAGLG
                     AVVFRWLITTFTHVFSGHADYSDAGRAAHSWFPALGPWFLLLAPVIAGLVYGPLVYRFA
                     PEARGHGVPEVMYAVAERGGRIPVQVSVVKALASALTIGSGGSVGREGPIVQIGSALGS
                     ALGRAARLPESRLRVLVACGAAGGIAATFNAPLAGPFFAMELILRDFAAESFGAVVLAS
                     VTASVVGRAVLGNAPFLDLPPFTLRNPVEYLLFVALGLVVGACGVLFTRVLYWIEDLCD
                     RLWRGPEWLRPAVGGVFLGGLLLLLPQMYGVGYPVLQNAVEGKYVLGFLLVLMLGKIVA
                     TSLTIGIGGSGGVFAPSLFIGAMAGTAFGIAVHTWFPSVTASPGVYGLIGMGAAFAGSA
                     RAPITAVIVLFELTGQYSVILPMLTAIVIATAVSRALSRDTIYTLKLRRRGIDLDKHPS
                     AQRLAGTKVAAVTEPLPEPLSADLPLELAAHALALSGHGILPVIDAEGRYQGCATARAV
                     AEAVAEDQSGQVGDLAELPPLVTSDSTLADALDALAQAPGTGLPVLTGGDELTGWITHQ
                     SVLSALEPAAVSATGRTSAGLP"
     gene            complement(19027..19593)
                     /locus_tag="L3Q65_RS12395"
                     /old_locus_tag="L3Q65_12395"
     CDS             complement(19027..19593)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009080711.1"
                     /locus_tag="L3Q65_RS12395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_12395"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_237599698.1"
                     /transl_table=11
                     /translation="MAAAKTPRADATRNRQQLLDVATRLFAAAGTEPSMRAIAAEAGVG
                     IATLYRHFPTRESLVDAVYQDQVSRLTAGAKDLLAELGPAAALRRWMDLFGDWIATKNG
                     MLETLLAMVESGEIAHAHTRTELLAAIDGLLEAGRSSGELRGDVPAEDIAAALIGIFTV
                     AGSAEHKAMAARLLDLLLDGLRVSA"
     gene            19672..20613
                     /locus_tag="L3Q65_RS12400"
                     /old_locus_tag="L3Q65_12400"
     CDS             19672..20613
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (18-199). E-value: 1.9e-28.
                     Score: 91.4. Matches aSDomain:
                     nrpspksdomains_L3Q65_RS12400_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009080708.1"
                     /locus_tag="L3Q65_RS12400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_12400"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_182889445.1"
                     /sec_met_domain="ADH_N (E-value: 4.2e-08, bitscore: 32.1,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.3e-11, bitscore:
                     43.7, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGKEASRAVRFEAFGGPESLRVREVPVPQAGPGQIRVRVAAAGL
                     NPMDWFMTSDSETAARFGLSLPCGFGTDYAGTVDQIGDGVSEFAVGDRVFGGALSRAVA
                     DYVVVDVAGTIAVGGEAHRTPDGVDDRTAAALAIAGCTAAAALAVVSPGPGDTVLVGGA
                     GGGVGVFAVQLARLAGARVIGTGSASSAEALQALGAEPVAYGEGLVDRVRALAPAGVTA
                     AMDLHGAETAQAARELGVPDGRITTIAGQIDGITPANGANAAPGAIEEIAGLVAAGQLR
                     VPIAASFPVEEIQTAVELQAGRHVHGKVVIDL"
     aSDomain        19726..20268
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_L3Q65_RS12400_PKS_ER.1"
                     /evalue="1.90E-28"
                     /label="L3Q65_RS12400_PKS_ER.1"
                     /locus_tag="L3Q65_RS12400"
                     /protein_end="199"
                     /protein_start="18"
                     /score="91.4"
                     /tool="antismash"
                     /translation="ESLRVREVPVPQAGPGQIRVRVAAAGLNPMDWFMTSDSETAARFG
                     LSLPCGFGTDYAGTVDQIGDGVSEFAVGDRVFGGALSRAVADYVVVDVAGTIAVGGEAH
                     RTPDGVDDRTAAALAIAGCTAAAALAVVSPGPGDTVLVGGAGGGVGVFAVQLARLAGAR
                     VIGTGSASSAEALQALGA"
     CDS_motif       20134..20196
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_L3Q65_RS12400_0001"
                     /evalue="1.40E-05"
                     /label="PKSI-ER_m5"
                     /locus_tag="L3Q65_RS12400"
                     /protein_end="175"
                     /protein_start="154"
                     /score="17.7"
                     /tool="antismash"
                     /translation="GDTVLVGGAGGGVGVFAVQLA"
ORIGIN
        1 cggagcggcc gggctctgcg acgtcgccgg cgccgaggtg gcggtcggcg cggctgcgga
       61 ggaagagccg ggcgcgccgc tgttctggct gcacgcggac aggaccgcga gcgcggccgc
      121 ggcggcaatc gcgtgggcgg ttcggcgcat cgcggtcctc cggtcagtgc cggagcgctt
      181 cgcggcggcg gtcgtactcg tcctggtcga tctcgccgcg cgcgaaccgc tgccgcaaaa
      241 tggcggtggc ggggtcggcc tcgtggccga gcccggccgg gcggcggacg agcagcgcgg
      301 tgaccacgcc gatcgcggcg agcagcgcga ctgccacgat gctcatcacg accgggccga
      361 cccattcggc ggcgcttccg tagtgccagt acatcattct tctctcctcg gctcaggacc
      421 gctgacgggt gtcggcggct tcgagcggct gcagcacttc gtcgatctcc cgccggggag
      481 tcgctggcag cgggtcggcg ttggccggcg cccagccgac gcgcaggacc atctgcggga
      541 acgcgcccga ggtgacctta tcctcgacgg tgcgccggac gtccggcaat tcgagcggct
      601 cggtcagcgg gcagctggcg aggccgaaac gggtcgcggt gagcagcgcg gcgctcgtcg
      661 cttcccccgc gcgcagccgc gacatccggt cgtcggacgc ggtgctcagc acgagcagca
      721 ccgtctcgtc atcttcgccg gccgcgccgg cggcttcggg cagttccggg ttcgggaact
      781 gacggccggg caacgcaccg ggagtctcgt ccggcagggg ggtgttgcgg gacgggacgc
      841 cgtccgggga ggcgtgccgt ccgctccacg cggcgagttc gatccggtag gcgggatcgt
      901 ggcgatgccg cagcgacgct tcctcgatcg cggtggccag gtagtaccgc tcggcgtctt
      961 cggcgacgcg caggacgacg ccttcgtccg ccactgcctg ggcgatcgct tcgagatgcc
     1021 ctcgcggaac gcgccaggaa ctgtgccggc ggcggtcggt gcggcggcgg gggatcgcgg
     1081 cggcgagcgc gacctcgtcg agagtgggct cgtgccgatg gagctcgatc gaggcgagat
     1141 gccccggttc ggccggattg ggcagccgcc gcacctcggt gcgccagccg agcgctgcga
     1201 aggcgatccg cgcgtggtgc agcgcggccc cgcagctgat catcaggtcc cgcccgtccg
     1261 gatcggtctg ggtgagctgc cgcgacggat cggcgtagag gtgcagggac cggtgcccga
     1321 ccgcgaaccg ccacggctgg gagttgtgca ccgacggcgc acggacggcc atcccgaccg
     1381 cggtcgtgac ggtgtagtcg tcgggaagtc cgcgttccat gaccgacctg ccttgtcgtc
     1441 tcgtccggtg atgcgtcgac agtggcagcc gcggcgggat gcggagcagg gccggaattc
     1501 cccgggtgcg gggactttcg ccggtcgtcg cccgccgtgg cggcgcgggt gaccttcgcg
     1561 gtcccgcacg ggccgaaaga cctctgccgc cgctgggcgc ccgggaggtt gcatggcgac
     1621 cgatcggggg cggtttcggc gacaggagtg aaatgtccaa agcacacgaa gcggaccggg
     1681 aaaccccggc cgcgtcccgg atccgggcgc tgggcctgac ctcggcgacc gggctggtag
     1741 cgggcagcgt gatcggcacc ggggtcttca ccatgcccgc cgtgctggcc ggcgcgggaa
     1801 ccagttcgct gctggtgctc ggcgtcgtcg cggccggcgc cgccgtgctg gcggtccttt
     1861 tcggacagtt gacgaagcgg gctccggatt ccgacggcgg gctctacgcc tacgcccggc
     1921 gggaattcgg cgatttcgcg ggctatctgg tcggctggtg ctactgggtt tcggcgtggg
     1981 cgggcaatgc cgcgatcgtc gcgtcgtggg tgctctacgt cgaagcgctc ttcggcatcg
     2041 aacacccctc ggtgtgggcg gacctcggca tcgcgctggc cgggctgtgg atcccggccg
     2101 cggtcaacct cgcaggcgtg cggcagatgg cgtggttcca gaacaccacc gtggtgctga
     2161 agttcctgcc gctgctgttc gtgggcgtgg tgggctggtt cttcgtctcg aaggccaatt
     2221 tcggtgcgtt caacgcgtcc ggcggaagcc tttacaccgc gatcgggatc gccgcgggcg
     2281 tcgcgctgtt cgcgttcatc ggggtcgaag tcgcggcggt gacggcgaaa cgggtgcgcg
     2341 agccggggcg caacgtcggc cgggcctcgg tgctgggcac cgccgccagc gcggtggtgt
     2401 acctggcggt gtccgcggcg gtgatgggac tcgtcccgca cgacgtcctc gtctcgagcg
     2461 gaactccgtt cgtgcccgcg ttcgaggcga tcctgcccgg cggcggctgg gccgggaagc
     2521 tggtcgccgc gcttgccgtc gtgtcgggaa tcggcgcgct gaacggctgg acgttggtga
     2581 cgacagaggt gtcgcgcgcc gcggcggcgg acgggctgtt cccgcgggcg ttcgcctggg
     2641 ccgaccgcaa ggacaccgcg tggttcggca tcgtgctcgc ggcgctgctg ccctcgctgc
     2701 tgatggtgtg gcgctacacc tcgggcaccg ggctggcggt cttttccttc ctggtgaacc
     2761 tggccgtcgt cacggtcgcc atcccgtacg tcttctccgc ctgcgcccag ctggcgtacc
     2821 tggtgtcgcg gaggcgccgg gtgcacggct tgctgctggt ccgcgacctc ggcatcaccg
     2881 ccgccgccgt gctcttctcg ctgtgggtga ccttcgccgc cggctacgcc gcggtgtacg
     2941 aggcgatgct cgtcctgctg gcgggcctgg tcctgcacgc gctgctcaag ggccgtgccg
     3001 cggcgggcag gcaaaaggcg gctgccgagg agaccggcga ccgatggcca cgcgcggctt
     3061 gaccgccgcc gtcccgacga aaggcaccgc atgaacttcg ctgtcgcgtc cgaaaccggc
     3121 aggctccggc aagtgatcct gcaccgcccg ggtccggaac tggcccggct gaccccgcga
     3181 aacattcacg aactgctctt cgacgacgtc atgtgggcga gaaaggcgaa ggaggaacac
     3241 gacgtcttcg ccgaggcgct gcgcgagcaa ggcgtacggg tgcactactt cgaccggctg
     3301 ctcgccgaaa ccctcgacga cccggacggc cgcgcgttcg tgctcgaccg ggtctgcacc
     3361 ccgcggaccg tcggcccggc gctggctccg acgctgcgaa agctgttcga cgacctcgac
     3421 agcccgagcc tcgccgagtc gctgatcggc ggcgtcctga aggccgacct gcacccgctg
     3481 cgcaccagca gcctgaaatg gcacatgctg cgggccgacg acttcctgct gccgccgctg
     3541 ccgaaccacc tgttcccgcg cgacacctcc tgctggatct acggcggcgt ctcgatcaac
     3601 ccgatggcga aacccgcgag gcagcgggaa accctgcacg cgcgggcgat ctaccgctac
     3661 cacccgatgt tcgccggagc cggattccgc acgtatttcg acggcgacga ggactgcttc
     3721 ccggcgaccg tcgagggcgg cgacgtccac gtcctcggcg gcggcgcggt cctcgtcggc
     3781 atgggggagc ggacgacgcc gatggcggtc gaactgcttg cccgggagct gttcggcagc
     3841 ggccaggcga acaccgtgct cgcggtcgaa ctgccccggt cgcacgcgac gatgcacctg
     3901 gacacgctga tgaccatggt cgacagggcc acgttcgtgc tctgcccgta cttcgacccg
     3961 aagctgcgct cgtggacggt gactcccggt ccggacgctc tggagatcca gcggaacgac
     4021 agtctgtggg agagcctcgg ccaagcgctc ggcgtcgagc gggtcactgt gctctccacc
     4081 gacgaggacg tccgcgccgc cgagcgcgaa cagtgggacg acggcaacaa ctacctcgcc
     4141 gtcgcgccgg gcgtagtcat cggctacgac cgcaacgtcg ccacgaacac catgctgcgc
     4201 aaacacggcg tcgaggtgat caccgtgccc ggcggcgaac tcggccgcgg ccggggcggg
     4261 ccgcgctgca tgagctgccc gatagaacgc gacccggccc gctgaacgcc cggaccgccc
     4321 gaccgaacag gagcttccga tgaatctgca gggccgcaac ctgctcaagg aaaccgacct
     4381 caccgccgcc gagttccgtt ccctcgtgga cctcgccgcc cggctgcgcc aggagaaacg
     4441 atcaggcgcg ccggcgcggc ggctcgccgg gcgcaacatc gcgctggtct tcgagaagag
     4501 ctcgacgcgc acccggtccg gattcgaggt cgccgcccac gacgagggcg cgcacatcac
     4561 ctacctaggc ccggaggaat cgcacctggg ccacaaggaa tccgtgaagg acaccgcacg
     4621 ggtgctcggc cgcgtgttcg acggcatcga gttccgcggc tcgtcccagg aggcggccga
     4681 aaccctcggc gcgtacgccg gggtcccggt gtggaacggg ctcaccgaca cctggcaccc
     4741 gacgcagatg ctcgccgaca tcctcaccat gcgcgaccac gcgccgggct cgctcgacga
     4801 cgtgtcgtac tgctacctcg gcgacgggcg caacaacgtc gccaactccc tgctcgtcac
     4861 cggtgcgctg ctgggtctcg atgtccgtgt ttgcgcgccg gagccgttgt ggccgaggga
     4921 agagatccgg cggatcgctg ccgggctcgc gggcgagtcg ggcgcgaaac tgctcgtgtc
     4981 cgacgacgtc gccgaggcgg tgcgcggagc cggcttcctg tacaccgacg tctggctgtc
     5041 gatgggcgaa ccggaggacg cctggggccc gcggatcgaa cagctgctgc cgtaccaggt
     5101 caacgccaag gtgctcgccg agacggggaa tccggcggtg aagttcttgc actgcctgcc
     5161 cgcgctgcac ggacgggaca ccgaaatcgg gaagcggctc ggcgaccggt acgggctcga
     5221 cgccctcgaa gtcaccgacg aggttttcga atcggcggcg tcggtcgtgt tcgaccaggc
     5281 ggagaaccgg atgcacacca tcaaagccgt catggtcgcg acggtgggag catgaggatc
     5341 gtcgccgcgc tcggcggcaa cgccctgctg gaacgcgggg aaccggccga gtccgacatt
     5401 caggagcacc acgtcctcgc cgccgccgaa gcgctcgccg cggtggcccg cgagcacgaa
     5461 ctcgtcctga cccacggcaa cggcccgcag gtcgggctgc tggcgctgga gagcgaacgc
     5521 gatccggcgc tgcgcaggcc ttatccgttc gatgtgctcg gcgcgcagac ccaggggatg
     5581 atcggctact ggctcgcgca ggcactgcag aacgccaccg gccgcccggc ggcggggctg
     5641 gtgagccgca cgctggtgcg tgccgacgat ccggctttcg ctgtcccggc caagttcgtg
     5701 ggcccggtgt acgaccgcgc gaccgccgag cggctcgccg cggaacgggg gtgggaggtc
     5761 cggccggacg gcgcggcgtg gcggcgggtg gtgccgtcgc cggaaccggt cgagctgatc
     5821 gagttgccct tcgtgaaagc cctgatggaa tcgggcgcga tcgtggtgtg cgggggaggc
     5881 ggcgggatcc cggtggccgc cgcctccccg gggttgcggg gtgtcgaagc ggtcgtcgac
     5941 aaggatctga ccgccgcgct gatcgcgcgc gagatcgggg ccgacgctct ggtgctgctg
     6001 accgacgtcg aggcggtgca ggacgattac ggcacgccgc gggcacggcc gatccgggac
     6061 gtcggcagcc gcgaactgcg gtcccgggat ttccccgccg gttcgatggg gccgaaggtc
     6121 gaggccgcct gccggttcgt ggagaacggc gggaagttcg ccgcgatcgg caggctgacc
     6181 gcggcggccg gactggtggc gggcacagcg ggaacgatcg tccgcgcgtg cggccctggc
     6241 ttcagctgac gagcgcccag gccagcacca gcccgccgga gttggtggcc aggtgcacca
     6301 gcatcggggc gagcagccct cgcccggtgt agcgccacca gcacaggaac acgcccgctc
     6361 cggcggcagc ggccatcgcc agcaccgaaa ccatcgcgag cggcagcccg ccgaccgtct
     6421 ggtgcacggc cgcgttctgg gtgagtgcga gcgacggcag cagatgccag agcccgaaca
     6481 gcgcggacgc gccgagcacc ggccaccatc gccaccgctc gcctgctccg agcagcgccg
     6541 gaagcacgcc gcggaacgcg acctcttcga cgagcacggt gccgagcgga atccgcacca
     6601 gcgcgagcca catgagctgg ccgaagcccg gcgaaccgat ccggccgtcg tggaacagca
     6661 cgcgcaacga cggaatcgcg gccgcgaggc cgaacccgag cgctacggcc gcgaacccgc
     6721 ccagcccgaa ccacagcatc cggcgcgcgt gcgcgcggcc gaatccgatc tcggcccagc
     6781 ggaccccggc gaagcgagcg aggaccagga gcacggcggc ggtgaccgcg ccgcagacgg
     6841 ggtaggccca gccgggcagc acccggttgg ccagcacagt cgccgccgcg agcagcagga
     6901 cggcgggaac cacagtgaga gcacgacgcc ggagatcggt gacttccggc agtttcggga
     6961 caacggcgga gacagacatc gtcattccag tgtgcctgcc gaaagggaca atggcgatga
     7021 cgaccatgga acgcgaaccg tatctggact ttctgcgtgc ggtcagcctg gtcgtggtcg
     7081 tgctgtggca ctgggcgttc acgatcctgc actggacgcc gaccgggccg cagcccacga
     7141 atccgctcgc gtacttccgg ggcctgtggg tgctcacctg gttcctgcag gtcctgccgg
     7201 tgttcttcta cgtcggcggg tcggtgcacc tcgcgtcgtg ggagcgtgcc cgggccaggg
     7261 gccagtcacg gcgctcgtac gtctggctcc atgtgaagga actggtcgcg ccggccggga
     7321 tgctggtcct tttctggacc acagccggga tcgtgctggc cgaggcgttc ggcgtacggt
     7381 ggatcggcgg cgcggtaatg ctgattctga gccccctgtg gttcctcgcg gtttacgtcg
     7441 gcctgcttct gctgctgccg ctcatggcgt ggctgcacga gcgcttcgac atcctggtcc
     7501 tggtgtggct cgccggggcc gccctgctga tcgacgtcct gcggctgcgc ttcggctggg
     7561 acgcggtgag ctgggtcaac gtcgccgcgg tgtggggctt ggcctaccag gcgggttttt
     7621 tccatcggcg catcgtcgcg gcctcgcgac acgtcgccgg aacgctgctg tgggcgggct
     7681 tgttcgctct cgccggactg gtgctgtcgg gcttgtatcc cggttcgatg gtcggagttc
     7741 cgggggagcg gatgtcgaac atgtcgccgc cgacgttcgt catcgtcgcg ctgctggcct
     7801 tccagatcgg gctgtgcgag atgctgcgcc cggccgtcga gcgtgctttg gccaagccac
     7861 gccggcagcg cgcgaccgca gtcttcaccc gatacgcgct gccgctgttt ctctttcaca
     7921 ccacgggaat ggccctggcc cgcgcagtcg tgtacttcgg cttcgaccgg cacctggccg
     7981 acgaccgggc gccggactgg atctggtggg ctgagcgccc gctggcgatt ctcggtccgc
     8041 tgcttttcac cgtgccgctg atcgccctct tccggcagcg acatgccgtg caccaagcgg
     8101 cgcacgagta gggccgcggc tttccgcgcc actggctgcc cgacgtggag cgtgtccggg
     8161 cggcgcggcg ccgggatcag gtgcagttga acagggtcat gaagccgtag tccatgtgca
     8221 gttgctggtg gcagtgcagc agcgagaggc ccggttggtc ggcgacgaag tcgaggtcga
     8281 gtttctggta gccgccgagc atgacgacgt ccttgaacag ccccgcggtg ggagtgccgg
     8341 cgacggcggc gacctcgacg gtgtgccggt gcaggtgcac ggggtgcacg tcgtcggtgg
     8401 cattgcgcag ccgcagccgg taccgcttgc cgcgctggac cgggatcacc ggctggttga
     8461 gggccgttga gtaggactgg ccgttgaggg tccaggcgtt gaagccgccg acggcggcgt
     8521 tgcgcttctc caccagcagg tcgatcgtct ggtccggggc cgcggcggcg gctccggcgc
     8581 gggcgaaagt ccggtagtcc caggtgaacg ggccgggtgc ggtccactgc gggggaccgg
     8641 tgcggccggc gtattcgacg gcgatgccca tcccggcgcc gcggtcgctg tcggccaggt
     8701 cgccgaggac ccacactccg ggacggttca tctccaccac cgcggagacg cgttccgccg
     8761 tgccgatcca cagcaccgga acccgcgccg gggcgggcac cggattgccg tccagcgcga
     8821 cgacgcggaa gacatggccg ggcaaggcga ggctgcggat ctcggtggcg ctgccgttga
     8881 gcacgtgcag cagcattcgc tgcccggccc ggaccttgat cggttcgcct tggccgagct
     8941 tgcggccgtt gacgctgaac gcgccgtagc cgacctcgta gccgcgcggc atccctcggc
     9001 cgagcgaatc ggccatcgct ttctcgcccc gctccttgag ttccggatcg ggcgcaccgg
     9061 ccaggaaatc ggcggccatg tccccggcgc ggctgaacgt gggcgcgaat tccttcaata
     9121 ccaggaaaac tccctggtcg taggcgccgg gattgagctt cggctcgatg tagaccggtc
     9181 cgacgagccc accgtactgg cccttcgcca gatcgctccc ggcgatcaga tggctgtggt
     9241 agaaacggaa tcccgccggt ccgggcgtga acgagacacg tcgcatgccg tgcgcgggaa
     9301 cgaacggagt gccctcctcc gcggatccgt cgacgtccgc gggcacctgc tggccgtgcc
     9361 agtgcacctg ctccgggacg tcggtgtcgt tgtgaacgtc caccaccgcg gggcggtcct
     9421 cggcgaaccg cagcaacgga cctgggaact gcccgttgta ggtcgtggtg gagaagatcg
     9481 cgtccggagc gagttcgacc agtccgctgc cgatccgcag cgtatagtcg gcttttcctt
     9541 ccggcagggg cgcggagggc gacgtgtcgc agcccgcgac catgtcgcct gcgctggcgg
     9601 tggccgcggc ccccacggtg atcttcaaca ggtcacggcg attgatcggc atcgagcaca
     9661 cgctcccttg ggtgagcacg tccagccgtc agcggagaga cccgaggccg cgatctgtgc
     9721 ggcacggccg cgagtctcaa gcatcgtact ccgatgacgg cacccgaaaa tgggctcgaa
     9781 cacgggaaac cgggtacccg gcccgggtgc ccacagggtc ggcgaacctc gccggagtcc
     9841 ggttcggtca agggtggacg gtgcgtcctg ctttgctgag agcaggcatt ccgcggcgga
     9901 caggacgttc gatgaaggac taacgcgggc ggcgccgacc ggctgagggc cagcgggtgc
     9961 ggtgcgcggg ccgggacgga cgagttccgg cggatcctgc tcagggtttc cagtctgaag
    10021 ggacgacggt gcggtcgtcg gcatcgtgct cggcgtgcgc ggtggcgtag cgctgtgtgt
    10081 cgtggtcgta ccaatcctga tagccgcgca tccaatcctg cattccctcg atgtacccgg
    10141 ccaatgccgg gctggcccag tcgcgggtcg gtcgcgccag actgctgaac gcgacgatct
    10201 ccgcgcgcac tcgtccggcg gtcgcttcga cagcctcggt cagggtgcgg ccttgggagg
    10261 cgtagagggt gaccatattg cggaactgcc cgggctgccg cgcctcgacc ggcaggctct
    10321 ggatgtcgtt ggcccagcac accacgttgt tggcgtgcat gcgcaattgg tggacagccg
    10381 gatggtggta ttcgtcggcg gtcacgggtg cgcagcctgc agtccggcgg tggacgccca
    10441 gagccgcatg ccggtggcga accggtcgaa gtgctcaggc gacagccggg cacgcagccg
    10501 gcggcacacg tccagccacg ccgtttcgcc gtagaccggg cacgcccggc tccggtcgtg
    10561 atcgagaacg tcgatcatcg cggtcaggtt ggccaaggtg tcaggcgtgt cggtgtcgac
    10621 gcggtccacg aagaggtcgt cggtgaggaa aaaccacaga aaataatcgg cgatgatctg
    10681 cagcaacgcc gtatcggcgc ggggatagca ccgggcggcg aggtaactgt agcgggtacg
    10741 ggccacccga tcgcggtaat cggcggtcgg aatgagcccg ttgtcttgtc cccagccgat
    10801 catggtctgt tccaccgcgg cggcctcggg atggcaggcg ccaggccagg ggacctgaaa
    10861 accgggaacc tcgatcgcgg cgaattcggc ggcgtcgtcc atggctgcct tccggtcgtg
    10921 cgcggaactc agggggtccg gcgctcgatc gcggagtccc tggccgcgaa cgccggtttc
    10981 ctgcggtggc tcgcctcatc gtgatcgagc catcgtagct ctcgaggacg cctgccgcgc
    11041 gggtcggggc gagagcgccg acgatgcgcg gtacgcaaga tttcctgata tagctcggca
    11101 tacgatgccg cgcgcgggtg tccggcatca gctgatcggc cgcggcggcg gagatgcgtc
    11161 ccgatctgct cgacggcgca cctgtcgacg acccagctct cctgctcggg cctgagggca
    11221 ccgacgccat cagctgcgcc gagcggtgac ccccctgcgg agatcgcccg gcaacggacg
    11281 gacgcgctgg agatcgcggc gtctgctcga ccgcagctgc cacgggacgc tggtgaccat
    11341 gacgccgggt tcgaacagca gtcgtccctt gagccgcagg gagctctggt tgtgcaggat
    11401 gttctcccac cagcggccga cgacgtactc cgggatgtag atgcacacga cgtcgcgtgg
    11461 gctggaccgg gcgaagttct tcacgtaggc gacgaccggg cgggtgattt cgcggtaggg
    11521 cgattccacg accttcaacg ggattttgat gccgcggcgt tcccattgcc gttgcagctc
    11581 gcgggtttcg gcgtcgtcga cgttcacggt gatcgcggtg agcgtgtcgg gccgggtggc
    11641 gcgggcgaag gcgatcgcac gctggctcgg tttgtgcaaa gtggacacga gcacgatggc
    11701 gtggacgcgg ctgggcagca gttcgctttc ctcgtcggga agcagttctt cgcggacgtg
    11761 ggtgtagtgc cggtgaacgg cgcgcatcat cacgtacagc gcggggatgg cgatgacgac
    11821 gaggtaggcc ccgtgggtga acttggtgac cagcacgacc gcgaggacga tcgcggtgag
    11881 ggtcgcgccg agggcgttga tggcgcggga gcgctggatc gcgtgccggc ttccggtgcc
    11941 cgcggccagt tcgcggttcc agtgccgcac catgcccgcc tggcacagcg tgaacgaggt
    12001 gaacacgccg aggatgtaga gctggatgag ccgggtggtc gagccgtcga acgcgtagat
    12061 caggacggcg gcgatgagcg cgagcgcgat gatgccgttg gagaacgcca gccggtcgcc
    12121 gcgcgtgtgc agttggcggg ggagatagcg gtccttggcg aggatcgagg ccagcagcgg
    12181 gaagccgttg aacgcggtgt tcgcggcgag gatcaggatc agcgcggtcg tggcctggag
    12241 gaaatagaac aggacggcgt ggtcgccgcc gaagaccgcg gcgccgatct ggctgatcac
    12301 cgtgcgctgc gggtcggtcg cgcactggcc ggcgaacccg gccagatcgc aggcgttctc
    12361 ggcgatgtgc accttcgcga tcagcgcgag cgcggtgatg ccgccgaaca tgacgaccgc
    12421 gatgacgccc atcgcggtca tcgtgcgggc cgcgttgacg gctttcggct tgcggaacgc
    12481 gggcacgccg ttggagatgg cttcgacgcc ggtgagcgcg gtgcagccgg acgagaacga
    12541 ccgcagcagc aggaaaatta gggcgaatcc ggtcaatccc acttgttcgg gacggatcgc
    12601 gtagcccgcg ctctcggcga ccggtgcgtg cccggcgagc gtgcgggaga agccgacggc
    12661 gatcatcagc agcaccgcga ccacgaagag gtaggtcggc gcggcgaacg cgcgcccgga
    12721 ttcgcggagg ccgcgcaggt tcatcgcggt caggacgacg atgaagccga tgtcgagtgc
    12781 gatccggtag ccgttgaggc cgggcacggc ggagatgatg ttgtcgacgc cggaggcgac
    12841 cgacaccgcc acggtcatga tgtagtcgac catcagcgcg ccggcgacga cgagcccggc
    12901 gtggctgccg aggttgcgcg aggcgacctc gtacgagccg cctccgctgg gataggcctt
    12961 caccacctgc cgataggaca cgaccacgac gctgagcagg accgcgacgg cgagcccgac
    13021 ccacggggcc agcaccagat acgtcagccc gccgatcgag aggatcagca ggatctcctg
    13081 ggtggcgtag gcgaccgacg acagcgggtc gctggcgaaa atgggcaggg cgagccactt
    13141 gggcaacagc gtttcgccga gggtgtcgct ccggaacggc cgcccgagca ccagccgttt
    13201 gagccatgac ataggtgctg gcacgtaccg cagcgtccct cggggaccgg tgcggcagcg
    13261 tatggatctc gtcaggatcc cggcctggcc gtagagattc cgttaacgcg cgtcagaaat
    13321 tcgtcaaagt cggaccggcg ggttcggcgg gtgcttactc tcccgcgcca tggtcgacga
    13381 ccgcgtcgtg cggatccttc gccgcactgg cgcggcggag gtgatcgacg cgcttctcac
    13441 cggtccggcg tgcctgtccc gcctgcgccg cacggtgccg cgccggacgc tggagcggtc
    13501 ggtccgcgcg ctggcggcgg agggcgcgct cgtccgggcc gacgcgggca gctgggacac
    13561 cggtctccgt gcggacacgg agttgcggct taccgcgagc ggcctggcgg tcgcggccgt
    13621 tttgtccgat tgggacgtct gggtccgggt gtacgaggac tatctccgcg atcggtagct
    13681 ccgcgtgtcc cgtcgtcggc ggacgcgcgc gaggggacct cggtttgccc ggggcgggtc
    13741 tttgcggcat ctttacgcgt ggagtgccgg gaagtctggt cggcctgccc gtgcccagcc
    13801 gggcgacggg cggtcgagcc gacccccggg gagtccgatg gcgctggtgc tggcgttcgg
    13861 cgtggtgctg ctggtcagcg tgtcgctgtc cggcgtggcc gcgcggacgg tgctgtcgac
    13921 ggcgttgctg ttcctgctcg cgggcgctct gctgggcgac ggcgggttcg gcctgatcca
    13981 catcgcgccc cgggatccgc tggtcacgtc gctcgccgac atcgcgttgt tcacggtgct
    14041 gttcaccgac ggccagcggg cgagcgtgcc cgcgctgcgg gagaactggc ggctgtccgg
    14101 gcgggcgctc gggctgggga tgccgttgac gatggtgggc atcgcggtgc ccgcgcattt
    14161 cctggtcgga ctggactggc cgacgtcgtt gctgctgggc gcgatcctct cgccgaccga
    14221 cccggtgttc gcggcggcga tcgtgggccg cgacgacgtg ccgttgcggc tgcggcggct
    14281 gctgaacgtg gagtccgggc tgaacgacgg gctcgcgctg ccgttcgtgc tgatcttcct
    14341 ggcgaccgcg acgcacacgt cgtcggatct gggcacggtc gtgttcgagc tggtgctggg
    14401 attggtgctg gggatagcga ttcccgcgct ggtcgctctc gcgtggcggc tgcgggtgct
    14461 gaccgccgag ccgcggctgc aggcgctcgg tccgctggcg gtcgcggtgc tgctttacgc
    14521 ggcgtgccac ctgaccgacg cgaatcctta tctggcggcg ttcgcggccg gctccacact
    14581 ggccactgtg gacaagacag cggccgagca cttcgagccg ctgggggacc tgctttcgga
    14641 gatcacgaag ttcgccgcgc tgctggtgtt cggcgcgctg atcacgccgg accggctctc
    14701 gcacttgagc gtcggcgcgt gggtgctcgc ggtgctggcc atcgttctgg tgcggcccgc
    14761 ggcgctggcg ctgtcgctgc tgcggactcc gatgtcggga cgcgaacgcg cgaccgccgc
    14821 gtggttcggg ccgaaagggt tcgcgtcggt ggtgtacggg ctgctggcgc tgcagtccgg
    14881 gatcgccgac agcgagctgg tgttcgatct ggtcgcggtg acgatcgcgc tctcgatcgt
    14941 gctgcattcc tccaccgacg tgccgatcgc gagactgctg cggatcgagc cgccggacaa
    15001 gctgcctacc ggccgtccgg cgagcgcggg cggcgaccgc aaagagaaag gaaagaaatc
    15061 atgagttccg gcggagccgc ccggctcgtc gtagcctggg ggcatgcgcg cagcggagct
    15121 ggccgaggag ttcccggtcg tcgacctcga ttcggacgcg ctggcggccg cgcgcctgct
    15181 cgccgagcac cggttgcccg ggctggtggt gacggaagcg tccgggtgtc cgcacacggt
    15241 gctgcccgcc tccgacgtcg tgcagttcct ggttccgcct tatgtgcgcg acgatccgtc
    15301 gctggccggg gtgctcagcg agtcgatggc ggaccgggtc gcggacaaac tcggcgggcg
    15361 gaccgtgcgc gagctgctgc ccggcgaacc gcgcgagctg ccgagggtgg acgcggacga
    15421 cacgatcgtg gaggtcgccg cgacgatggc ccggctgcgg tgtccgctcg tggcggtcat
    15481 gcgggaccgg acgctgctgg gcgtggtgtc cgcgtcgcgg ctgctggagc acgcgttgac
    15541 gcctcgctga tcccggcggt ccgccgatga gcacggtcat cgcggtcgtc gtgttcgtgg
    15601 tggcctacgt tttcatcgcg accgagaaga tcccgaaaat gacggccgcg ctggccgggg
    15661 cgggcgtggt gctcgcgacc ggggtcagcg ggtcggccga cgcgttcttc tccgaggaca
    15721 ccggcgtcga ctggaacgtg ctgttcctgc tgctcggcat gatgatcatt gtcgggatcc
    15781 tgcgccgcac cggggtgttc gagttcgtcg cgatctgggc ggccaagcgc gccaaggggt
    15841 cgccgctgcg gatcatgctg ctgctggtgc tgatcaccgc ggtcgcctcg gcgttcctgg
    15901 acaacgtgac cacggtgctg ctgatcgcgc cggtgacgct gctggtgtgc gaccggctcg
    15961 acatcagccc ggtgcccttc ctgatcgccg aggtgctggc ttccaacatc ggcggcaccg
    16021 cgaccctgat cggcgacccg ccgaacatca tcatcggcag ccgcgcgggc ctggcgttca
    16081 acgacttcct gctcaacctc gcgccgatcg tcgcgctcga actcgtcgtg ctggggctgg
    16141 tgctgccgtg gctgttccgc ggttcgttca ccgtcgaccc gcagcgggtc gccgacgtca
    16201 tggcgctgaa cgaacgcgaa gcgatccggc agccgaagct gctgatcaag tccggcgccg
    16261 tgctgctgct ggtgttcgcg gggttcgtgc tgcattcggt ggtgcacctg gacccgtcgg
    16321 tggtcgcgct gctcggcgcg ggcctgctcg tgctgctgtc gggcacgccg ccgaagcagt
    16381 acctggacgg cgtcgaatgg gaaaccctgc tgttcttcgc cggcctgttc atcatgatcg
    16441 gggcgctggt caagaccggt gtgatcgact ggctcgcgaa gctcgccgct ggcgccaccg
    16501 gcgggaacgc gctgctggcg gtgttcctga tcctcggggt gtccgcgctg ctgtccggcg
    16561 ttatcgacaa catcccttac gtggcaacga tgagcccgct cgtgctcgcg ctcacccacg
    16621 acatcccgga ccccgcgcat tccgaggcgc tgtggtggtc cctggcgctc ggcgcggact
    16681 tcggcggcaa catgaccgcg gtcggggcca gcgccaacgt ggtcgtgctg ggtctcgccg
    16741 ctcgggcggg cgcgccgatc tcgttctggg aattcacgaa gaagggcgcg gtcgtcacgg
    16801 tgatcaccgt gctcgtcgcc gcgccgtacc tgtggttgcg ctacttcgtc ttctgatccg
    16861 ccgtccgcgg gcgcgagcgc tgttcgctgt gaggcgtggc tgtccagctc gcagggcctg
    16921 tcgggaccgc ggtggctcgg cgaagtatgt gaagggaacc ctgaggaact ctgagtacgc
    16981 aaggattccc ctcacgtctc taccaagccg gatatacggg cggatcgggc atttcgccga
    17041 ccatttgggg ccgttgtgga cggtagtcga gcggaaacgc cgcggcttaa gttccgggcg
    17101 cagggatcag gcgccctcgc ggacttctgc ggacagggag ccgcgcaccg ctgccgaaaa
    17161 atgtccttgc cgcccggtcc ggtgtgagcg atcccgcaac catgtccgtg cgcaattgtt
    17221 gcatactgca tcaatgtcgt cgggtgagag tgcggggaaa cgcgggctgg tcgtgccggt
    17281 gcgccagccg gtgggccggt gggtgcggga gagccgggcc gggctggtcg ggctggcggt
    17341 gctgatcggg gcgggcgcgg gtttgggcgc ggtggtgttc cggtggttga tcaccacgtt
    17401 cacgcacgtg ttctccgggc atgcggacta ttcggacgcc gggcgtgcgg cgcattcttg
    17461 gttcccggcg ctgggcccct ggttcctgct gctggccccg gtgatcgcgg gcttggttta
    17521 cgggccgctg gtctaccggt tcgccccgga ggcgcgcggg cacggggtgc cggaggtgat
    17581 gtacgccgtg gccgagcggg gcgggcggat tccggtgcag gtgagcgtgg tgaaggcgct
    17641 ggcgtcggcg ttgacgatcg gctccggcgg ctcggtgggc cgggaaggcc caatcgtgca
    17701 gatcgggtcc gcgctgggct cggcgctggg acgggcggcg cggctgccgg agtcgcgact
    17761 gcgcgtgctg gtggcgtgcg gtgcggcggg cgggatcgcg gcgacgttca acgcgccgct
    17821 ggccggtccg ttcttcgcga tggaactgat tctccgcgat ttcgcggccg agtcgttcgg
    17881 tgcggtggtg ctcgcgagcg tgacggcgag cgtcgtcggg cgtgcggtgc tggggaacgc
    17941 gccgtttttg gatctgccgc cgttcacgct gcggaatccg gtggagtatc tgctgttcgt
    18001 ggcgctcggc ttggtggtcg gtgcgtgcgg agtgctgttc accagggtgt tgtactggat
    18061 cgaggatctg tgcgaccggc tgtggcgggg cccggagtgg ctgcgcccgg cggtgggcgg
    18121 ggtgttcctc ggcgggttgc tgcttctgct gccgcagatg tacggggtgg gctatccggt
    18181 gctgcagaac gccgtcgagg gcaagtacgt cctcgggttc ctgctggttc tgatgctggg
    18241 gaagatcgtg gcgaccagtc tgacgatcgg gatcggcggc tcgggcgggg tgttcgcgcc
    18301 gtcgctgttc atcggcgcga tggccggcac cgcgttcggg atcgctgtgc atacgtggtt
    18361 tccgtcggtg accgcgtcgc cgggggtgta cgggctgatc gggatgggtg cggcgttcgc
    18421 gggttcggcg cgggccccga tcacggcagt gatcgtgctg ttcgagctga ccggccagta
    18481 ttcggtgatc ctgccgatgc tgaccgccat cgtgatcgcg accgccgtga gccgcgcgct
    18541 gagccgggac acgatctaca cgctgaaact gcgccgccgc ggcatcgacc tggacaaaca
    18601 cccctccgcg caacggctgg cgggcacgaa ggtcgccgcg gtcaccgaac cgctgccgga
    18661 gccgctgagc gcggacctgc cgctggaact ggccgcgcac gcactcgcat tgtccggcca
    18721 cggaatcctg ccggtgatcg acgcggaggg ccgctaccag ggctgcgcca ccgcccgcgc
    18781 ggtcgccgag gcggtcgccg aggaccagtc gggccaggtg ggagacctcg cggagttgcc
    18841 gccgctggtg acgagcgatt ccacgctcgc cgacgcgctg gacgcactcg cccaagctcc
    18901 gggaaccggt cttccggtgc tgaccggcgg cgatgagctg accgggtgga tcacgcacca
    18961 gtcggtgctg agcgcgctgg agccggcggc ggtgagcgcg accggccgga cctcggcggg
    19021 gctgccctag gcggaaacgc ggagtccgtc cagcagaagg tccagcagcc gggccgccat
    19081 tgccttgtgt tcggcggaac cggccacggt gaagatgccg atgagcgctg ccgcgatgtc
    19141 ttcggcgggg acatcgccgc ggagttcgcc actgctgcgg cctgcttcga ggaggccgtc
    19201 gatggccgcg agcagttcgg ttcgggtgtg ggcgtgggcg atctcgcccg actcgaccat
    19261 cgcgagcagc gtctcgagca ttccgttctt ggtcgcgatc cagtccccga acaagtccat
    19321 ccagcggcgc agcgccgcgg ccgggccgag ttccgcgagc aggtccttgg ctccggcggt
    19381 gaggcgcgag acctggtctt ggtagaccgc gtcgacgagc gactcgcggg tggggaagtg
    19441 ccggtagagg gtggcgatgc cgactccggc ctcggcggcg atcgcgcgca tcgagggctc
    19501 ggtcccggcc gctgcgaaca agcgggtcgc gacgtccagc aactgctggc ggttgcgggt
    19561 cgcgtctgcc cggggggtct tcgcggcggc caaaacggat cacgctccac ttgtgctagc
    19621 ttcgaggatg taaacggagc atagtccgtt tacctgaccc cgaggagaca gatgagcggg
    19681 aaagaagcga gccgggcggt gcgattcgag gcgttcggcg gtccggagtc gttgcgcgtc
    19741 cgcgaagtgc cggtgccgca ggctggtccg gggcagattc gcgtacgggt ggccgcggct
    19801 gggctgaacc cgatggactg gttcatgacc tcggactcgg agaccgccgc gcggttcggg
    19861 ctcagcctgc cgtgcggatt cgggaccgac tacgccggga ccgtcgacca gatcggcgac
    19921 ggagtaagcg agttcgcggt cggcgaccgc gtcttcggcg gcgcgctgtc ccgtgcggtg
    19981 gctgactatg tcgtcgtgga cgtcgccggg accatcgcgg tgggcggcga ggcgcaccgc
    20041 actccggacg gtgtcgacga ccgcaccgca gccgcgcttg cgatcgcggg ctgcacggcg
    20101 gctgcggcgc tggcggtggt cagtccgggc ccgggcgaca cggtgctcgt cggcggcgcc
    20161 ggaggcgggg tcggcgtgtt cgcggtccag ctcgcacgcc ttgccggtgc gcgagtgatc
    20221 gggacggggt cggcgtcctc ggccgaggcg ctgcaagcgc tgggggctga gccggtcgcg
    20281 tatggcgagg gcctggtcga ccgggtccgt gcgttggctc ccgccggcgt caccgccgcg
    20341 atggatctgc acggggcgga aacggcgcag gcggcccgcg aactcggcgt gccggacgga
    20401 cgcatcacca ccattgcggg ccagatcgac gggatcactc cggcgaacgg cgccaacgca
    20461 gcgcccggag ccatcgagga gatcgccggt ctggtggcgg cgggacagct ccgggtgccg
    20521 atcgcggcga gctttccggt cgaggagatc cagaccgcgg tcgagcttca ggcggggcgg
    20581 cacgtgcacg gcaaggtcgt catcgacctc tagccggccg gagtggttcg cgaccagggg
    20641 tagcgaccgg cgtccgcgtc gccgtagtcc ggggcgagat agatgtgcag gcgctggcgg
    20701 ccgaacggct tcgcgaccac atcgcgcaca cggcgcagct gctgatcagc tgcgccgagg
    20761 acgaaccgaa ccggccgttg cagtcccgac cgcgccggtc agggcgcggc cggggtgaag
    20821 ttctcccggt ggatcatgcg cggcgccatg cggcggcgtt tgaacgcctt caccccggcg
    20881 tcgaccatcg gcggcggccc gc
//
