LOCUS       NZ_CP091381            22535 bp    DNA     circular CON 18-AUG-2024
DEFINITION  Amycolatopsis sp. FU40 chromosome, complete genome.
ACCESSION   NZ_CP091381
VERSION     NZ_CP091381.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. FU40
  ORGANISM  Amycolatopsis sp. FU40
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 9944196)
  AUTHORS   Reisman,B.J. and Bachmann,B.O.
  TITLE     Biosynthesis of Apoptolidin Family Glycomacrolides
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9944196)
  AUTHORS   Reisman,B.J. and Bachmann,B.O.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-2022) Chemistry, Vanderbilt University, 1234
            Stevenson Center Drive; Room 7330, Nashville, TN 37235, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 23-JAN-2022
            Assembly Method                   :: Flye v. 2.9
            Assembly Name                     :: NFU40_flye_2.9
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 47.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_021903635.1-RS_2024_08_18
            Annotation Date                   :: 08/18/2024 04:30:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,491
            CDSs (total)                      :: 9,417
            Genes (coding)                    :: 9,360
            CDSs (with protein)               :: 9,360
            Genes (RNA)                       :: 74
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 7 of 57
            Pseudo Genes (incomplete)         :: 50 of 57
            Pseudo Genes (internal stop)      :: 5 of 57
            Pseudo Genes (multiple problems)  :: 5 of 57
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:13:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1576094
            Orig. end                         :: 1598629
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP091381.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Brian O. Bachmann,
            Vanderbilt University.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22535
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="10"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22535
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22535
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12535](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12535)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    447..459
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.63"
                     /tool="antismash"
     misc_feature    1280..1291
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     gene            1880..3871
                     /gene="ligA"
                     /locus_tag="L3Q65_RS08320"
                     /old_locus_tag="L3Q65_08320"
     CDS             1880..3871
                     /EC_number="6.5.1.2"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003911 - DNA ligase (NAD+) activity
                     [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /gene="ligA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020635616.1"
                     /locus_tag="L3Q65_RS08320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_08320"
                     /product="NAD-dependent DNA ligase LigA"
                     /protein_id="WP_182894986.1"
                     /transl_table=11
                     /translation="MDVRERIQELADQVVVLRDAYYRGSPVVADAEYDAIEDELRGLIE
                     ASPELAPDPNPLDQVGGPAVLHAPIRHSRPMLSLEKATKPEQVEAFFDRFPGQPVVVMP
                     KLDGLSLALVYEDGRLARAVTRGDGTTGDDVTMLVRALTDGIPHQVSAPGRVEVRGEAV
                     MLRSTFAAYNTAHPDKPLINPRNAAAGTLRAKDPAAVAERRLRFFAFDLDTEPGSAETD
                     LGSGLLALGFTAADMRRCADAASAQAVITTIEQQRNDLDYDIDGAVLRLADRAAYAAAG
                     TRSSSPRGALAYKFAAEEKTTVLSDVVWDVGKTGKIAPVAWLEPVFVGGTTVTRATLAN
                     QEVIRARGIKIGDTVLVRRAGDVIPFVAGVLDESKRTGAEREIVPPSTCPSCEQPLTEQ
                     GNSRELFCTNVSCPAQTVRRLIHWASRAAADIDAIGGVWIERLAEAGILEHPSDFYRLT
                     KERLLEFDRIGEVSATRMIESIDASRQVGLRRALIGLAIPMASEGTAARLCRAGFASLE
                     AVLDAGVDGLVEVEDIGPKVAASLVEHLTRLRPELERLRERGVSLDVLEEDLPPAVVAG
                     APLEGKTVVVTGAISDPRSGEKVPRPTFQRLCETAGATTASSVSASTDLLITGADVGAS
                     KLTKAEKFGVEVVDQGVIWEQLIAAGVV"
     misc_feature    complement(1908..1922)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     gene            complement(4185..5132)
                     /locus_tag="L3Q65_RS08325"
                     /old_locus_tag="L3Q65_08325"
     CDS             complement(4185..5132)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009077509.1"
                     /locus_tag="L3Q65_RS08325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_08325"
                     /product="ketopantoate reductase family protein"
                     /protein_id="WP_182894987.1"
                     /transl_table=11
                     /translation="MKILMFGRGVIAAMYGWALERAGHDVEFYVRPGRAAEYGESIDLD
                     LRDLRGRRGAETWPVRYREELEPGHEFDLIVLSVQHYRLPEAAAFLAPRAGKATVLVFG
                     NIWSEPLAAIGDLPVEQVAWGFPQGGGGFGEDGVLRGMLMPLAVFGTLGEPPTERERVV
                     RQVFRDAGFRVRERPDFRGWLWVHFISDAGLHSQGVRVGSLSSLARSRSDLREALLAGR
                     ELVRLLEARGVDVRQHRGALLLFRAPTWLTVPVLGWLLARFPPARVNLEAHSDPDAREP
                     REICRDVLAEARRLGVTVPRLEAAEPYFGLERTE"
     misc_feature    complement(4227..4229)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(5152..5170)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.39"
                     /tool="antismash"
     misc_feature    5155..5173
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.84"
                     /tool="antismash"
     misc_feature    5167..5181
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.99"
                     /tool="antismash"
     misc_feature    complement(5186..5200)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.05"
                     /tool="antismash"
     misc_feature    5194..5209
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 20.61"
                     /tool="antismash"
     gene            5202..5366
                     /locus_tag="L3Q65_RS08330"
                     /old_locus_tag="L3Q65_08330"
     CDS             5202..5366
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="L3Q65_RS08330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="L3Q65_08330"
                     /product="hypothetical protein"
                     /protein_id="WP_182894988.1"
                     /transl_table=11
                     /translation="MSTRGSGDAFLRRTIDSAEDGGTDPVSAAALANAVSGEGQAVIEP
                     IRDFPHNPA"
     gene            5423..5809
                     /locus_tag="L3Q65_RS08335"
                     /old_locus_tag="L3Q65_08335"
     CDS             5423..5809
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="L3Q65_RS08335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="L3Q65_08335"
                     /product="hypothetical protein"
                     /protein_id="WP_182894989.1"
                     /transl_table=11
                     /translation="MKRIAVSLAVSAVAVLGGAGAASAAGYPTSNFGDDIIGGAAGGTL
                     TWYNRSVGVSGYVRDDAGSGSTTVTFEFRQAGTLFDVQTRSALNDYKTFGWTEPGPSGG
                     FSKVDIYLGHGNSRILIASVPRKV"
     gene            complement(5995..7710)
                     /locus_tag="L3Q65_RS08340"
                     /old_locus_tag="L3Q65_08340"
     CDS             complement(5995..7710)
                     /EC_number="7.-.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009077513.1"
                     /locus_tag="L3Q65_RS08340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_08340"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_182894990.1"
                     /transl_table=11
                     /translation="MSIGRLYWNALAGQWRGGLVLLACSVLEGLPAFFSGRLVELAVNS
                     GFAAGKPGIGLGWLGVFGLAALAGAFGSRLVWRQLGKVVEPLRDALVTAVVRGVLHDPA
                     PPRSGPDARGVARITQHVEVVRDATGGLLVQARGMIVTTAAAIAGLVTVAGSLALPVVV
                     PVVLALAGFAALLPSLARRQRALTLADEGTAAATGSIFAGLRDVVACGAEPVAALAADH
                     AVDRQASAAVRVARSAALRSMIVALGGFVPLVLALALAPSMVARGELTAGAALGALVYL
                     ATTLQPALRGLAATASTVVLRLLVALRRLAETTAPPERRPATESPAGLGLAVRDLTFRW
                     GAAPEPVVHGLNLDLRPGEHLAVVGPSGIGKSTLAGLLTGLLPPHSGEVRLGGVPVSEL
                     ADRPRHLVLVPQQAYLFAGTLRENLSLFHPEASDRRLAAAAEAVGAAPLLARLGGLDAE
                     LGPGAEGISAGEAQLLALARAYASPAGVVVLDEATSTLDPAAEVRAERAFAARGGTLIV
                     IAHRLSSAIRAHRVLLMDGPETLLGRHEELLAASARYAEMMRAWLPERSRLEAS"
     gene            complement(7814..9466)
                     /locus_tag="L3Q65_RS08345"
                     /old_locus_tag="L3Q65_08345"
     CDS             complement(7814..9466)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009077514.1"
                     /locus_tag="L3Q65_RS08345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_08345"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_182894991.1"
                     /transl_table=11
                     /translation="MAGPADRLLTSTALLDRPRLAAVIVASLLSASAGLLLPGALATAT
                     DAVLSGRSSTGAVIWLLAIGAAEIAADAVMVVLPARLTSNASAWLRRRVTDRLLALGTS
                     SPFAPGDAVSRVSGDCAAAGGVAAIVVQLVATGLLSSGAVVLLALLDWRLALVFLGSLP
                     FALLLARSHLRGTAKDVLAYQRVSGELSARLLDAVAGLRTIAASGTADAEAARVLRPLP
                     RLNLAGQGMWRTQARMVWRAGLLLPTVEILTLAAAGFGVLDGRLSAGDVLAALGYVALG
                     LGLVTQIPLLTTLSRIRSAALRITEVLDAEPPPRGALGLLPGNGALELRGATVHGALAD
                     VDLTIPGGCFAAVVGSSGTGKSTMVSLLAGLRRPDAGQVLLDGRDLAVLRPDELRAVVG
                     YASAEPALLGATVADAVAYGSWASVPAVDEACRTARIHDILVRLPHGYDTPLAETPLSG
                     GETARVGLARALARNPRVLLLDDATASLDTVTERAVTAELGRRTRVVVTHRAAMAARAD
                     VVVWLAAGQVRAVGPHARLWQMPGYRAVFTEET"
     gene            complement(9439..9711)
                     /locus_tag="L3Q65_RS08350"
                     /old_locus_tag="L3Q65_08350"
     CDS             complement(9439..9711)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="L3Q65_RS08350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="L3Q65_08350"
                     /product="hypothetical protein"
                     /protein_id="WP_237599256.1"
                     /transl_table=11
                     /translation="MSDREDGPQSGHSAHSPSTPDPRRSAAAVLVKSLTSSDATLAADA
                     RGKRHRPLFFGRPRLTAAASPISASTAPADRHAKGVPWPDPPIAS"
     gene            complement(9834..9968)
                     /locus_tag="L3Q65_RS08355"
                     /old_locus_tag="L3Q65_08355"
     CDS             complement(9834..9968)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038159.1"
                     /locus_tag="L3Q65_RS08355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_08355"
                     /product="class III lanthipeptide"
                     /protein_id="WP_182894993.1"
                     /transl_table=11
                     /translation="MENVLELQALEAPEALEGQGLDHHGHSHYSAWCGDSTLSLLLCY"
     CDS_motif       complement(9903..9968)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MENVLELQALEAPEALEGQGLD"
                     /locus_tag="L3Q65_RS08355_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9834..9902)
                     /prepeptide="core"
                     /locus_tag="L3Q65_RS08355_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="7.90"
                     /molecular_weight="2397.6"
                     /monoisotopic_mass="2396.1"
                     /core_sequence="HHGHSHYSAWCGDSTLSLLLCY"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MENVLELQALEAPEALEGQGLD"
                     /leader_location="[9902:9968](-)"
                     /alternative_weights="2415.6"
                     /alternative_weights="2433.7"
                     /alternative_weights="2451.7"
     gene            complement(10001..12535)
                     /gene="lanKC"
                     /locus_tag="L3Q65_RS08360"
                     /old_locus_tag="L3Q65_08360"
     CDS             complement(10001..12535)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013222285.1"
                     /locus_tag="L3Q65_RS08360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_08360"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_237599257.1"
                     /sec_met_domain="micKC (E-value: 0.0, bitscore: 1116.7,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 1.1e-12, bitscore: 46.9,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 1.2e-05, bitscore: 24.5,
                     seeds: 156, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.2e-09, bitscore:
                     35.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVRYEAFCFADPLFFDEPRESPGAAGDLAAGLPLPGPEWTDETR
                     GIWRSLRPAGRKLPAQGWKIHVSAGLDNAAGVLSRVHRYCVEHRIAYKHLRSRATLLSR
                     NSKYAPREGSGKLVTIYPHSEEALAAILSDLSAELEGEHGAYILSDLRYREGPLYVRYG
                     GFAEQWTEHAGTRVLAIRHPDGTLVPDRREPSFSVPEWAPIPSCLSGSLAARKNGAAFP
                     YRVTGSLHFSNGGGVYLAERGAGRKTVVLKEARPHAGLDREGADAVARLNHEREVLERL
                     ADVPGIPRVHEQFTVWEHHYLAMEHLPGIALSSWLARHYPLTSGTRAEGGLAAYRERAL
                     AVLAQVERIVADIHRHGIVFGDLHGKNILVDEHDRVSLIDFELAVEADSGDRPGLGAPG
                     FRAPADRHGFEIDEHALAALRLWLFLPLVMLLELAPGKLRGLADFAQQRFDLPDGYADG
                     VVSVLAPRTASPSTHTALDEPRPDWSLVRKQIAEAILAAAAPERSDRLFPGDIEQFRSG
                     GTGFGVGAAGVLHSLHVAGAGRYPEYEEWLLAAVRRQPPSRPGFFDGSHGIAYVLEEFG
                     YAAEADELLAASRSLVDQTTDHGLESGLAGIGLTRLHFATTRGDNEFGRQALDVALKLA
                     SAFETADPPGRFARAGLLSGWSGPALLFLRLYEHTGEPSWLTLADRVLARDLEECAPAS
                     DGSLQVRDGALRLLPYAAIGSAGILLVAEQIARRLPDSAAAESLPGLRAACRGEFVIHP
                     GLLYGRCGLAAALSFADEPDREAIDLHLARLSWHGVPYHGGLAFPGNQLLRLSTDVSTG
                     SAGVLRTLAALLDGAEPLPFLGSAPSPHTSGR"
     misc_feature    complement(12716..12732)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 22.27"
                     /tool="antismash"
     misc_feature    13002..13017
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.23"
                     /tool="antismash"
     gene            complement(13141..14034)
                     /locus_tag="L3Q65_RS08365"
                     /old_locus_tag="L3Q65_08365"
     CDS             complement(13141..14034)
                     /GO_function="GO:0001216 - DNA-binding transcription
                     activator activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020639192.1"
                     /locus_tag="L3Q65_RS08365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_08365"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_182894995.1"
                     /transl_table=11
                     /translation="MLDIPRLRVLRAVVASGSIRASAAALGYTPSAVSQQITTLQRETG
                     LQLFERSGRGIEPTEAGRTLAAEAEALFEAFSRVEQVASELRAGRVGRLSIGYFGSAGS
                     TWLAPTVAALRTEFPGLRLDLMLTEFTQGDPDIDIFVEETGAEHPGSVVVHRLAEDPYL
                     AVVRLDDPLAGLPEVPLAALAERHWVDNDLREGPCRQVLLNACTQAGFSPSFVVETHDY
                     RTAMSFVATGIGLTVVPELGIGELPDGLATVALASPAPVRHLSLAVKKPIAEHPAARRA
                     VELLESLVCSGKALAG"
     gene            14117..15013
                     /locus_tag="L3Q65_RS08370"
                     /old_locus_tag="L3Q65_08370"
     CDS             14117..15013
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1166: transporter,
                     EamA family"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005463661.1"
                     /locus_tag="L3Q65_RS08370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_08370"
                     /product="DMT family transporter"
                     /protein_id="WP_182894996.1"
                     /transl_table=11
                     /translation="MTDLVETAPPARKTDFGKIAAAAGLAVVLWASSFVAIRSVGHALS
                     PAPLALLRLAVAAVTLTVFAVAKGAVRIRLSRKAFLLVAAYAVLWLAAYTVVLNAGERH
                     VDAGTAALLVNLAPLMVAVAAGKFLGEGFSRSLVVGSLVALGGAALIATGATGSNDWAG
                     VLLCLLAAVLYAAGVMVQKITLRHVDGLTAIWLGCVVGTVVLLPWTPQLVSELQVAPTG
                     AVLGSVYLGVFPTAVGFTAWAYALRRTDAGRLTMVTYAVPAVAVLLSWLLLAETPTAYG
                     LVGGVLCLAGVAISRRR"
     gene            complement(15010..15792)
                     /locus_tag="L3Q65_RS08375"
                     /old_locus_tag="L3Q65_08375"
     CDS             complement(15010..15792)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009077522.1"
                     /locus_tag="L3Q65_RS08375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_08375"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_182894997.1"
                     /transl_table=11
                     /translation="MDDEYPFDNASAPASDRMSALEASYDTTTFRHLAELGVGAGWSCW
                     ELGAGGGSVARRLAEQVGPDGHVLATDLDTRLLADLPANASAVRHDVRAEPVPDREFDL
                     IHARLVLIHFPERDELVAKLAGALAPGGWLVLEEIEPRGQTVLETPDEASATIFRSVQG
                     RILDLLERAGSDVEWAGQLPEVLAGAGLREVGSARSTTRWPGGGPEIRLLAANSVELAE
                     KLTADGVPPEEIEQFRRVLADPRFTVSSYPLVSGWGRR"
     gene            complement(15845..16678)
                     /locus_tag="L3Q65_RS08380"
                     /old_locus_tag="L3Q65_08380"
     CDS             complement(15845..16678)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009077524.1"
                     /locus_tag="L3Q65_RS08380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_08380"
                     /product="endo alpha-1,4 polygalactosaminidase"
                     /protein_id="WP_182894998.1"
                     /transl_table=11
                     /translation="MHSLPGRISRATAAAAVLIGSSACALGAAGPAESAPLPAPHSQVA
                     LPAPHAGFDYQIGGPYQPPAGVQVVSRDHGAPAAAGVYNICYVNAFQAQPGAEGEWGDL
                     VLRDANGDVVLDPDWNEALLDLRTADKRSRIADKVGGWIDECAGKGYQAIEPDNYDSFT
                     RSQGLLSARNAQDLVKLLSQRAHGKGLAIAQKNTSELSSSRVGNGLDFAVAEECGEQDN
                     CAEYTQYFGDRVIVIEYTPDGLRNACAKWGATLSVVQRDRDVTPQGESGYVRATC"
     gene            complement(16853..18160)
                     /locus_tag="L3Q65_RS08385"
                     /old_locus_tag="L3Q65_08385"
     CDS             complement(16853..18160)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013225764.1"
                     /locus_tag="L3Q65_RS08385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_08385"
                     /product="alpha-glucosidase/alpha-galactosidase"
                     /protein_id="WP_182894999.1"
                     /transl_table=11
                     /translation="MTTKITFVGAGSVVFTQGLLADLFAYPELAEVHVALHDIDPERLR
                     IAHAAAGRIAEARGAKPVLTAHLDRREALDGADFVVNMVQIGMGEATRVDFDIPARFGV
                     QQTIGDTLGVGGIFRALRTFPFLRELGEDIAQVCPRAWLLNYTNPMAMNVQYLSETLGP
                     DRVAGLCHSVYWTVHDLAKLLEVPLPEVTYHAAGINHQAWILRLEHQGADLYPRLAELS
                     EDPQLRRRVRFDMFRRLGYYPTETSEHSSEYVPWYLGHASEIERLRLPIGAYLDVVAEN
                     EAEYERTRQAIERDEPLTVEGTNEYAPQIIHSVVTGTPRTVYGNVLNRGLIPNLPATGA
                     VEVPCLADATGIRPTRVDALPPQLAALNRTYLSTTELVVRAAVEDDPRHIRHAAMTDPA
                     TAAALPVERIWELCDEMVLAHGDALQPGLRKTLGSS"
     gene            complement(18157..19095)
                     /locus_tag="L3Q65_RS08390"
                     /old_locus_tag="L3Q65_08390"
     CDS             complement(18157..19095)
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_function="GO:0016773 - phosphotransferase activity,
                     alcohol group as acceptor [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1276: PfkB domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020630069.1"
                     /locus_tag="L3Q65_RS08390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_08390"
                     /product="carbohydrate kinase family protein"
                     /protein_id="WP_182895000.1"
                     /transl_table=11
                     /translation="MPHRFDLLVLGDVNPDVVLGPLTEDLDFRQREHLVGHGCITLGGS
                     AAITAAGAARLGLKVAFAGRIGDDAAGRFVRDLLDGRGVDTQALTVDPTLPTPLTAILT
                     RGGGRAIVTSSGVLDAVSAADVPAELLANARHVHASSYFLLPKLAAGLPELFRTARAHG
                     ATTSLDTNDDPARQWDPSGIKLVLQETGFLLPNAAEALQLSGESSLLDAAAHLAAQGPT
                     VVVKNGADGALAHHRGETVTVPASPISPLDTVGAGDSFNAAFLAATLRGLPLRDALRAG
                     VAGGGRSTLARGGIDGQPTWNELDLTETESA"
     gene            complement(19119..20006)
                     /locus_tag="L3Q65_RS08395"
                     /old_locus_tag="L3Q65_08395"
     CDS             complement(19119..20006)
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009077531.1"
                     /locus_tag="L3Q65_RS08395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_08395"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_182895001.1"
                     /transl_table=11
                     /translation="MTTRAHVAPVSAARLPEVARQPRRWRLPFSPWHLLLAPLALLFAA
                     PLVWLLLSSVMSNAEINRFPPSLWPSGIDFSGYRYVLENALFLRWFTNSLIVSVVTVAA
                     NLVFGSLGGYAFARMRFRGSKAMLGLMMATMAVPFQLTMIPTFLVMKKLGLIDSLGALI
                     VPSLVTPFAVFLLRQFFLSLPRELEEAAWIDGCSRLRVLIRIVLPLSRPALSTVAVLTF
                     LSTWNDLTWPLIAINHDTQYTLQLGLTTFQGQHHTNWAAVMAGNVITVLPVLLAFLGAQ
                     KTFIQSITSSGLKG"
     gene            complement(20003..20917)
                     /locus_tag="L3Q65_RS08400"
                     /old_locus_tag="L3Q65_08400"
     CDS             complement(20003..20917)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009077532.1"
                     /locus_tag="L3Q65_RS08400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_08400"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_237599258.1"
                     /transl_table=11
                     /translation="MSVHPGPITVAPAAKTRRRRETAAAWAYLSPSVVVIIGLGLVPVV
                     WSLVLSFQADDLVTPSRFVGVDNYAALAQDPHFGQAVGNTLLYTALYVPLSIVLGLALA
                     LALNRRVRFIGVYRTLMFVPFVLSATAQGVLFSFILDPEFGVANSLLHRIGLSPQGFLT
                     DPAQALLVLVAITLWSGTGFCMVVFLAALQDVPPSLIEAARLDGAGPFRILRHVTLPAV
                     LPVTTFLTLWQLIQSLQVFDLTYVTTKGGPLGSTTVIVYFIWQQAFQNFTAGYGAAAAY
                     VLAVVLLALGLGVRLLRRTKEVR"
     misc_feature    complement(20645..20647)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(20928..22205)
                     /locus_tag="L3Q65_RS08405"
                     /old_locus_tag="L3Q65_08405"
     CDS             complement(20928..22205)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009077534.1"
                     /locus_tag="L3Q65_RS08405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_08405"
                     /product="extracellular solute-binding protein"
                     /protein_id="WP_237599259.1"
                     /transl_table=11
                     /translation="MRVRTLTRRGFLRGAAAMALVPAAAACAEAPAATSGPVTVEMWHG
                     QSDTGLKVLKQLVAAFQRENPGIRIDLGGGVLADAMLQKVTAALASGSYPDIAYIFGSD
                     LASIARSPRVADMGDVVHGQFWKPALEAVTVNERVRAVPAMLDSLAVACNRKLFQQHGV
                     PLPDASWRWPDFVATAKKLTNRGQGQFGTAWPGAGDEDTVWRLWPMIWDLGGTIVGQDG
                     RSIGFADSGVQALEVIRKLAADRSVYIDPKPGSEQMYQAFASGRIAMVPTGPWQLPDIL
                     GAGIDYHVVPLPTFTGKPITISGPDTWTVFDNGDRRLAAAKTFLRWLTAPGQDVVWDVG
                     AGSLPLSAESQRLPEWQRKTRDTAGLSVFAESLENSHVRANHPAYPQVSQAVAAAIVSV
                     LLGRATPADAMRDCASAANAALIIPR"
     misc_feature    22205..22219
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.49"
                     /tool="antismash"
ORIGIN
        1 gcctctcgcc cgcgacaact ccggcggtgc ccgcccgatc cccgcctgcc ctcgcagacc
       61 gcgcttgtcc cgtacccgcg gcaacttcca cccgccccca aaccgccgct gcgatccggc
      121 cagccgcctc cgcccgcccc ttgccctcgg ttgcctcgac cggatccacc cgcctgatct
      181 cgacccccgg ccgcaacccg gcaaccgtcg ccgtcaccac cgcctgttcg cccaacccgg
      241 gcagcacctg cccgatgtag tcgagaaaaa tgtcgctggg cccgatcacc agaacccctc
      301 gcgtgcgcaa ccgcggccgc gtgtacatca gatatgccag ccgatgcagc gccaccgcgg
      361 tcttcccggt ccccggcccg ccctgcacca ccagcactcc cgcatacccg tcgcgcacga
      421 tccggtcctg ttcggcctgc agcgtcgtga cgatgtcgcc catccgcccg gtccggtccg
      481 ccgtgagcgc ggctagcaac gccgcctccc cgacgaggac tccggggtcc gccgcaccgg
      541 gatcgaacaa ctcgtcgtcc agcgcggcaa ccacccgtcc ccgggtcgtg atccgccgcc
      601 gcctccggac cccgagcgcc tccgccatgg tcgcggtgta gaacggctgc gccgccggcg
      661 cccgccaatc gagcagcagc ggctcgtcca cgccgtcctc gaacaacccc aagcggccga
      721 tgtacctccg gctcccgtcg cgcatctcca gccgcccgaa acacagcccg tcctcgacag
      781 ccgccagccg ggccgactcc gcccgccagc gcgccgcgac ctccggatcc gcgctttcgc
      841 gcccccgtgc cgcctcctcg cgcaacgcgt cgagcctgcc gtacaggctg gtgacgtact
      901 cctgttcgcg ggcaagctcc cgctcgacct ggttttcagc cggcacccca gaactccccg
      961 ctgtcgggtg aacgatggca tcgagggtgc gcgccgatcc ggagaaagaa cagtcttgtc
     1021 tttgccggcg gcgtcagccg aacggttttt ccgcccgaac cggacgctgc cgtcgaggcc
     1081 tggccccgga actccggccg ccccaaggcg ggcctccggg cgagattcgc gctggccagg
     1141 ttcgcggccc gccgcaccgc ttccgccggc aacggcgttt ccgctggtcc agcgcccgcg
     1201 cacgcaccgc cgcgacgagt tcgcccgagg ccgaccgcgc cggcacggcc acgccgcaca
     1261 acggcggcac cccgtcgctg taatcgaacg ccacgtcccg gtcccgggcg tcggcgagca
     1321 gcttttccca ttcccgcccg gaatattttt cgggcggctc ggcgcgcggt ccggaagcgg
     1381 cgagaaccat ttccgtcgca gccttggaag gcagcgccca accggcacgc atcgcgcaga
     1441 tctcgtcgga ttccgcagcc gaggagcgcc cgtccggaat cggctggcac gccgacgctg
     1501 gccgagcagc cggtgggcgg ccgccaattg ggtaggcccg gcctcgccgt tccgcgccag
     1561 ttcctccggc agaagaaacg cgccttccag cacgccgcgc ccgggtttac gcgccatcgg
     1621 aattccgtcc ggaatcacgc gtcgccgtcc tccgggtttt atcgccggaa ccgcattctc
     1681 cgggcacact tcctcgcttt ttctcgaaac cggagaaatt cggaaagatc cgtgcggcga
     1741 agaacgttcc tggcccacag ggctcggctg ccgccccttc ccggcagccg cggggtcacc
     1801 cgatcggcag ccccgcggcg accgcccggt ttgcgtcgca gtccggtttt gtcggtgggg
     1861 ccgggtagcg ttccggtccg tggacgttcg ggaacgtatt caggagctgg ccgatcaggt
     1921 cgtagtgctg cgcgacgcgt actaccgggg ttcgccggtg gtggcggacg cggagtacga
     1981 cgcgatcgag gacgagctgc gcgggttgat cgaggcgagc ccggagctgg ccccggaccc
     2041 gaacccgctg gaccaggtgg gcgggcccgc ggtgctgcac gcgccgatcc ggcattcgcg
     2101 gccgatgctg tcgctggaga aggcgacgaa gccggagcag gtcgaggctt tcttcgaccg
     2161 gttccccggg cagcccgtgg tcgtgatgcc caagctcgac ggcctgtcgc tggccctggt
     2221 gtacgaggac ggccgcctgg cgcgagcggt cacccgcggc gacggaacca ccggcgacga
     2281 cgtgaccatg ctcgtgcgcg ccctgaccga cggcattccg caccaggtca gcgccccagg
     2341 ccgggtcgag gtgcgcggcg aggcagtgat gctgcggtcg accttcgccg cctacaacac
     2401 cgcacacccg gacaagccgc tgatcaaccc ccgcaacgcc gcggcgggca cgctgcgcgc
     2461 gaaagaccca gccgcggtcg ccgagcgtcg gctgcgcttt ttcgccttcg acctggacac
     2521 tgaaccgggc agtgcggaaa ccgacctggg cagcggtctg ctggcgctcg gcttcaccgc
     2581 cgcggacatg cgccgttgcg ccgacgcggc ctccgcgcaa gccgtcatca ccacgatcga
     2641 gcagcagcgc aacgacctgg actacgacat cgacggcgcc gtcctccggc tcgccgaccg
     2701 cgccgcgtat gccgccgcag gcacccgttc gagttcgccg cgcggggcac tggcgtacaa
     2761 gttcgccgcc gaggagaaga ccaccgtact gtccgatgtg gtctgggacg tcggcaaaac
     2821 cggcaagatc gccccggtcg cgtggctgga gccggtcttc gtgggcggga ccacggtcac
     2881 ccgcgcgacg ctggccaacc aggaggtgat ccgcgcccgc ggcatcaaga tcggcgacac
     2941 tgtgctggtc cgcagggcgg gcgacgtcat cccgttcgtc gcgggcgttc tcgacgagtc
     3001 gaaacgcacc ggggcggagc gggagatcgt gcccccgtcg acgtgcccgt cgtgcgagca
     3061 gccgctcacc gaacagggca acagccggga attgttctgc accaacgttt cctgcccggc
     3121 ccagaccgtg cgccggctga tccactgggc gtcccgggcg gccgccgaca tcgacgcgat
     3181 cggcggcgtg tggatcgaac ggctggccga ggccggaatc ctggaacacc cgtcggactt
     3241 ctaccggctg accaaggaac gcctgctgga attcgaccgc atcggcgagg tctcggcgac
     3301 gcggatgatc gaatcgatcg acgccagccg ccaggtcggc ctgcgccggg cactgatcgg
     3361 gctcgcgatc ccgatggcgt cggaaggcac cgccgcccgc ctgtgccgcg ccggattcgc
     3421 ttcgctggaa gcagtgctcg acgcgggcgt cgacggtctt gtcgaagtag aggacatcgg
     3481 gccgaaggtc gccgcctcgc tggtggaaca cctcacccgg ctgcgccctg aactggaacg
     3541 cctgcgagaa cgcggagttt ccctggacgt cctggaagaa gacctcccgc ccgccgtcgt
     3601 cgcaggcgcg ccgctggaag gcaagaccgt agtggtgacc ggtgcgatca gcgacccgcg
     3661 atccggggag aaggtgcccc gccccacctt ccagcgcctg tgcgagacag caggcgcgac
     3721 caccgcgtcc tccgtctcgg caagcacgga cctgctgatc accggcgccg acgtcggcgc
     3781 gagcaagctc acgaaggccg agaaattcgg cgtcgaggtc gtggaccagg gggtgatctg
     3841 ggaacagctg atcgcggccg gagtggtctg aacccgcttt gccgggacgg gttcgccggg
     3901 tctgccggat cgaggcgacg ggcgtgctgg cgcgccgcat gaccgagaac cccttgcccg
     3961 gcaacggatt cacctgaacc cttcggggag cggcacggtg cagggatcgc gcgctttcgg
     4021 cgacggctgg cgaggctccg gacgcggatg gatgctcgcc gcccggcgtg ccgatcagcc
     4081 gtcgcacgcg ctgacttcca gagcccgatt ccttcgatcc gccatctggc aacgcttcgc
     4141 ccgcccgcca accgatccgc ggccatcggc cgaaacccgg cggctcactc cgtcctttcc
     4201 agaccgaagt aaggctccgc cgcctctaat cgcggcaccg tgacgcccag ccgccgggcc
     4261 tcggccagga cgtcgcggca gatctcgcgc ggctcgcggg catcgggatc ggagtgcgcc
     4321 tcgagattca cccgcgccgg gggaaagcgg gccagcagcc accccagcac cgggaccgtc
     4381 agccaggtcg gcgcccggaa cagcagcaac gcgccccgat gctgccgcac gtcgacgccc
     4441 cgggcttcga gaagccgcac aagctcgcgc ccagccagca acgcctcccg cagatcgctc
     4501 cgggaccttg ccagcgagct cagcgaaccc acccgcacgc cctgcgagtg cagacccgcg
     4561 tccgagatga agtgaaccca caaccagccc cggaagtcag gccgttcccg gacccggaac
     4621 ccagcgtcgc ggaacacctg ccgtacgacc cgctcgcgtt cggtcggagg ctcgccgagg
     4681 gtcccgaaca cagcgagcgg catcaacatc ccgcgaagca cgccgtcctc gccgaaaccg
     4741 ccgccgccct ggggaaagcc ccacgcgact tgctcgacgg gcagatcgcc gatcgcggcc
     4801 agcggctcgg accagatgtt gccgaacacc agcaccgtcg ccttcccggc gcgcggcgcc
     4861 agaaacgccg ccgcctccgg gagccgatag tgctggacgc tcagcacgat cagatcgaac
     4921 tcatggcccg gttccagctc ctcgcggtag cgcaccggcc aagtctcggc gccccgccgc
     4981 ccccgcaggt cgcggagatc gaggtcgatc gactccccgt actccgccgc gcgaccgggg
     5041 cggacataga actcgacatc gtgccccgcc cgctccaagg cccagccgta catcgccgcg
     5101 atcacgccgc gtccgaacat caagattttc actgtcgcac ctcgccggag cctaaaactg
     5161 gagacaatct ccacttgcga agatatggag acgatctcca gttgtcaacg aggggctccg
     5221 gcgacgcctt cctccgccgg acgatcgaca gcgccgagga cggcggcaca gacccggtct
     5281 ccgccgcggc actggccaac gcggtcagcg gagagggcca agccgtcatc gagccaatcc
     5341 gggatttccc gcataatccc gcatagaacg ccgcggcaca gtacgattcc gcccagcatc
     5401 gaccactctc tgggggaaaa tcatgaaacg catcgccgtc agccttgccg tgtccgcagt
     5461 cgccgtcctc ggcggagcgg gggccgcgag cgcggcaggc tacccgacgt cgaacttcgg
     5521 cgacgacatc atcggcgggg ccgccggggg cacgctgacc tggtacaacc gctcggtcgg
     5581 cgtcagcggc tacgtccgcg acgacgccgg ttccggaagc accacggtga ccttcgagtt
     5641 ccgccaggcg ggcacgctgt tcgacgtcca gacccgctcg gcgctgaacg actacaagac
     5701 cttcggctgg accgaacccg gcccgtccgg cggcttcagc aaggtcgaca tctacctcgg
     5761 ccacggcaac agcaggatcc tcatcgcctc ggtgccgcgc aaggtctgag cggggcgttc
     5821 acctgcggcg gaatccgtgc tgcggcgggc ttccagaggg agtatcgctc ggtcggcgac
     5881 ggagcaggcg aacacggccg ggaacgcccc gctcaccgac ggagcggtgg cggcgaacag
     5941 cgggagctgc atggcttgcc gctccggctc ttcgcaggcg gcggtcccgg ccgttcagct
     6001 ggcttcaagg cgagatcgct ccggcagcca agcccgcatc atctcggcgt accgcgccga
     6061 agcagcgaga agttcctcgt gccggcccag cagcgtctcc ggtccgtcca tcagcagcac
     6121 gcggtgcgcc ctgatcgcgg aggacaggcg gtgtgcgatc actatcaggg tgcctccccg
     6181 ggcggcgaag gcgcgttccg cgcggacctc cgccgccggg tccaaagtgg acgttgcttc
     6241 gtccagcacg acgactccgg ccggcgaggc ataagccctc gccagtgcga ggagctgggc
     6301 ttctccggcg gaaatgccct ccgcgccagg gccgagttcg gcgtccaggc cgccgaggcg
     6361 ggctagcagc ggggcggcgc ctacggcttc cgcggctgcg gcgagacggc ggtcggaggc
     6421 ttcggggtgg aacagggaca ggttttcgcg cagggttccg gcgaagaggt aagcctgttg
     6481 cgggaccagc accagatgcc gggggcggtc ggccagttcg ctgacgggca cgccgcccag
     6541 ccggacttcg ccggagtgcg gtggcagcag gccggtgagc agaccggcga gggtcgattt
     6601 cccgatgccg ctcgggccga ccaccgcgag gtgttcgccg gggcgcaggt cgaggttcag
     6661 gccgtggacg accggttccg gggcggcgcc ccagcggaag gtcaggtcgc gcacggcgag
     6721 gccgagtccg gcggggcttt cggtcgctgg gcggcgttcg ggcggggcgg tggtttcggc
     6781 gagccggcgc agggcgacga gcaagcggag gacgaccgtg gacgcggtgg cggccagtcc
     6841 gcgcagtgcg ggttgcaagg tggtggccag gtagacgagc gcgcccagcg ccgcccctgc
     6901 ggtcagttcg ccgcgggcga ccatcgacgg cgcgagggcg agcgcgagca ccagcgggac
     6961 gaatccgccg agcgccacga tcatcgaccg cagcgcggcc gacctggcga cccgcaccgc
     7021 ggccgaggct tgacggtcca ccgcgtggtc ggcggccagc gcggcgaccg gttcggctcc
     7081 gcaggcgacg acgtcgcgca gcccggcgaa aatcgagccc gtggcggctg cggtgccttc
     7141 gtcggccaac gtgagcgcgc gttgccgccg ggccagggag ggcagcagcg cggcgaatcc
     7201 ggccagcgcg agcaccaccg ggaccacgac cggcaacgcc agcgaccccg cgacggtcac
     7261 cagcccggca atcgccgccg cggtggtgac gatcatgccg cgcgcctgga cgagaagccc
     7321 gccggtggca tcgcgcacga cctcgacgtg ctgggtgatc cgcgcgacgc cgcgagcgtc
     7381 cggcccgctc cgcggcggcg cgggatcgtg cagcaccccg cgcacgacgg cggtcaccag
     7441 cgcgtcgcgc aacggctcga cgactttgcc cagttgccgc cacaccagcc gcgagccgaa
     7501 cgcgccggcg agagcggcga gtccgaatac cccgagccag ccgaggccga tgccgggctt
     7561 gcctgccgcg aacccgctgt tgacggccag ttcgacgagc cgtccggaga agaacgcggg
     7621 cagtccttcg aggacggagc aggccaggag aaccagcccg ccgcgccatt gcccggccag
     7681 ggcgttccag tagaggcggc cgatgctcat ggtccctccg cgtgcacggt gcggttgtgt
     7741 ccgtgggctt gctgcgccgc gagcccacgc cacgaactcg cctcggcgcg gcgcccggcg
     7801 aacgcgttcc cgctcacgtt tcctccgtga acaccgcgcg ataccccggc atctgccaca
     7861 accgcgcatg cggcccgacc gcccggacct gccccgccgc cagccacacc accacgtccg
     7921 cccgcgcggc catcgcggcc cggtgcgtca cgaccacccg ggtccggcgg ccgagttccg
     7981 ccgtcacggc gcgttcggtg accgtgtcca ggctggcggt ggcgtcgtcg agcaggagca
     8041 cccgcgggtt ccgcgcgagc gccctcgcga ggcccacccg ggcggtttcc ccgccggaca
     8101 acggagtttc ggcaagagga gtgtcgtaac cgtgcggcaa gcgcacgagg atgtcgtgaa
     8161 tgcgcgcggt ccggcaagcc tcgtcgaccg ccggaacgct ggcccaggaa ccgtaagcga
     8221 cagcatcggc gacagtggcg ccgagcagcg cgggctcggc cgaggcgtat ccgactacgg
     8281 cccgaagctc gtccgggcgc agcacggcga ggtcgcggcc gtcgagcagc acctgtccgg
     8341 cgtcggggcg gcgaagaccg gccagcaaag agaccatagt ggactttccc gtgccggaac
     8401 ttcctactac tgcggcgaaa cagccgccgg gaatggtgag gtcgacgtcg gcgagcgccc
     8461 cgtggacggt ggctccgcgg agttccaggg cgccgtttcc gggcagcagt ccgagtgcgc
     8521 cgcgaggcgg gggctcggcg tcgaggacct cggtgatccg gagcgcggcc gagcggatcc
     8581 gggaaagggt ggtgagcaga gggatttgcg tgaccaggcc gagtccgagc gcgacgtacc
     8641 caagggcggc gaggacgtcc ccggcgctca accgcccgtc caggacaccg aaaccggcgg
     8701 cggcgagggt gaggatttcc accgtgggga gcaagagacc ggctcgccac accatccgcg
     8761 cctgcgtgcg ccacatgcct tggccggcga ggttcagccg aggcagcgga cgcagcaccc
     8821 gggcggcttc ggcgtcggcg gtgccggacg cggcgatcgt ccgcagaccg gcgacggcgt
     8881 cgagcagccg ggcggacagt tcgccggaaa cccgttggta ggcaagcaca tccttggccg
     8941 ttccgcgcag gtgcgaccgc gcgagcagca aggcgaaggg gaggctgccg aggaagacga
     9001 gtgcgagccg ccagtccaga agcgcgagca ggactaccgc gccggaggac aggagaccgg
     9061 tcgcgaccag ctgcaccacg atcgcggcga cgccgccagc cgctgcgcaa tcgccggaca
     9121 ctcggctgac cgcgtcgcct ggggcgaacg gcgagctggt gcccaaggcg agcaaacggt
     9181 cggtgacgcg gcggcgcagc caggcgctcg cgttgctggt caggcgggcg ggaaggacca
     9241 ccatgacggc gtccgcggcg atctccgcgg cgccgatggc gagcagccag atcaccgcgc
     9301 cggtgctgct tcggccgctg agcaccgcgt cggtggcggt ggcgagggcg ccgggcagca
     9361 acagtccggc actggcagag agcagcgacg cgacgatcac cgcggcgagc ctgggacggt
     9421 ccaggagcgc ggtcgaggtc aggaggcgat cggcgggtcc ggccatggca ctcccttcgc
     9481 atggcggtcg gcaggcgcgg tgctggctga gatcggcgaa gcggctgcgg tgagccgggg
     9541 gcggccgaag aacaacgggc gatgccgttt tcctcgggcg tctgcggcga gcgtggcgtc
     9601 ggaggaggtc aatgacttga cgaggaccgc ggcggcggag cggcgcgggt ccggcgtgct
     9661 cggcgaatgc gccgagtgcc cgctctgcgg cccatcctcg cggtcggaca tcgccggact
     9721 ctggccggat cggcgacctc gacctcgccg cgaccaccgc cgccaagcgg ggcagaatga
     9781 acggggcggg aacggcgcac ttgtcctgcg ccgttcccgc cctgcccgcg cggtcagtag
     9841 cagagaagca ggctgagcgt gctgtcgccg caccatgcgc tgtagtggct gtggccgtgg
     9901 tggtccagtc cctggccttc gagggcttcc ggggcctcca gcgcctgcag ttccaggacg
     9961 ttttccatgg gtgttccctt ctctcggggt ccgccggcgc tcatcggccg gaggtgtgcg
    10021 gggacggtgc ggagcccagg aagggcagcg gttccgcgcc gtccagtagt gcggcgagcg
    10081 tgcggaggac ccccgcgctg ccggtgctga cgtcggtcga caggcgaagc agctggttgc
    10141 cggggaaggc cagcccgccg tgatagggga cgccgtgcca ggacaagcgc gccagatgca
    10201 ggtcgatggc ttcccggtcg ggctcgtcgg cgaaggacag cgcggcggcg agcccgcacc
    10261 ggccgtagag caggccgggg tggatcacga actccccgcg gcaggcggcg cgcagcccgg
    10321 gcaggctctc ggcggccgcg gagtccggca ggcgccgggc gatctgttcg gcgaccagca
    10381 ggattccggc gctgccgatc gcggcgtagg ggagcaggcg cagggcgccg tcgcggacct
    10441 gcagcgatcc gtccgacgcg ggagcgcatt cctccaggtc gcgggccagc acccggtcgg
    10501 caagggtgag ccaggacggc tcgccggtgt gctcgtacag ccgcaggaac agcagcgcgg
    10561 gcccggacca gccgctgagc aggccggccc tggcgaagcg gccgggcggg tctgcggtct
    10621 cgaacgcgct cgcgagcttg agcgcgacgt ccagtgcttg gcggccgaat tcgttgtcgc
    10681 cgcgggtcgt cgcgaagtgc aggcgggtga ggccgattcc ggcgagcccg ctttccaggc
    10741 cgtggtcggt ggtttgatcg accagcgacc gcgacgcggc gagcagttcg tcggcttctg
    10801 ccgcgtagcc gaattcctcg aggacgtacg cgatgccgtg gctgccgtcg aagaacccgg
    10861 gccgcgaggg cggttgccgc cggacggccg ccagcagcca ctcttcgtat tccggataac
    10921 ggccggctcc ggcgacgtgc agcgagtgca gcacgcccgc ggctccgacg ccgaaccccg
    10981 tgccgccgga gcggaactgt tcgatgtcgc cggggaacag ccggtcacta cgctccggag
    11041 cggcagcggc gaggatggct tccgcgatct gcttgcggac cagcgaccag tccggccgcg
    11101 gctcgtccag cgcggtgtgc gtcgagggcg atgcggtgcg cggggcgagc acggagacca
    11161 caccgtcggc gtacccgtcc ggcaggtcga accgctgctg cgcgaagtcc gcgagcccgc
    11221 gcagtttgcc gggcgcgagt tccagcagca tcaccagcgg aaggaacagc cacagccgca
    11281 gcgcggcgag ggcatgttcg tcgatctcga aaccgtgccg gtcggcgggt gcgcggaaac
    11341 cgggggcgcc cagccccgga cggtcgccgg aatcggcctc gacagccagt tcgaagtcga
    11401 tcagcgacac ccggtcgtgc tcgtccacca ggatgttctt cccgtgcagg tcgccgaaca
    11461 cgatcccgtg ccggtggatg tccgcgacga tgcgttcgac ctgggcgagc acggccagcg
    11521 cgcgttcgcg gtaggccgcg agaccgccct cggcccgcgt gccgctggtg agcgggtagt
    11581 gccgggcgag ccagctgctc agcgcgatgc cgggcaggtg ctccatcgcc agataatggt
    11641 gctcccacac ggtgaactgc tcgtgcacgc gcgggatgcc cggaacgtcc gccagtcgtt
    11701 cgagcacctc gcgttcgtgg ttcagccggg cgaccgcgtc ggcgccttcc cggtccagcc
    11761 cggcgtgcgg ccgggcctcc ttcagcacga cggtcttccg gccggcccct cgctcggcca
    11821 gataaacgcc gccgccgttg gaaaagtgca gggaaccggt cacccggtac gggaatgcgg
    11881 ccccgttctt gcgcgcggcc aggctgccgg acagacagga cggaatcggc gcccattccg
    11941 ggacggaaaa ggacggttcc cggcggtcgg gcacgagcgt gccatccgga tggcggattg
    12001 ccagcacccg ggttccggcg tgttcggtcc actgttcggc gaatccgccg taccggacgt
    12061 aaagcgggcc ttcgcggtag cggagatcgc tcagaatata cgcgccgtgc tcgccttcca
    12121 gctcggcgga aaggtcggac agtatcgcgg cgagcgcctc ttcggagtgc gggtaaatcg
    12181 tgacgagctt gccgctacct tcgcgcggag cgtatttcga attgcggctc agcagggtcg
    12241 cccgggagcg cagatgcttg tacgcgatcc gatgctccac acagtaccga tgcacgcggg
    12301 acagtacgcc ggccgcgttg tccagacctg cggagacgtg gattttccag ccctgggcgg
    12361 gaagtttccg gcccgccggg cgcagcgacc gccagatccc gcgcgtctcg tccgtccact
    12421 cgggtcccgg cagcggcagc cccgcggcca ggtcgcctgc cgcgcccggc gattcgcgcg
    12481 gttcgtcgaa gaacagcgga tcggcgaagc aaaaagcctc gtaccggacg tccatgaaaa
    12541 cgaacccttc cctttccccg aggaaaaccg ggcgacttcg atgtcggacg gtgacaccat
    12601 tcccgcacga ggggggtgcc ccggccaatc cgccaacccg ggggttcgac gctcctcgtc
    12661 agggtgacgg acgcgggttt gggtcgctaa accggggact gcgcgtgagt catccctacc
    12721 cgatcggggt gtaacgaagt cggtttccgg tcggccgccc aggtcggcgc ggaaagagcc
    12781 ggtgaaattg gcagcgggcc atcaacccgt tccggtgagc cggcttccgc ccgtcgtccg
    12841 gcgcgaaccc ggtgcggact ggtccgttcg gggcggcgcg gcgcattcgc gtcgcgaatg
    12901 tggtgcattc gttaccggac aatgcccggc cgcccgattc ccgcctccgg caccgtgccg
    12961 tgaaggactc cttgagggaa tcagattccc tcaaggagtc cttcacggct tttccagccc
    13021 aactcccagg ccgcgggcac cacttcggcg accccgggcc cccggttggc tgtccgtgag
    13081 gggggacccg cacggactct gagtccctca cggcagtccc cgaggccggg agggcgatgc
    13141 tcacccggcc agtgccttcc ccgagcacac caggctttcc agcagctcca ccgcgcgccg
    13201 ggcggccggg tgctccgcga tcggcttctt caccgccagg ctgaggtgcc ggaccggcgc
    13261 gggagaggcc aacgccaccg tggcgagacc gtccggcagt tcgccgatgc ccagttccgg
    13321 caccaccgtc aacccgattc ccgttgccac gaaagacatc gcggtccggt agtcgtgcgt
    13381 ctcgacgacg aaactcggcg agaaaccggc ctgtgtgcag gcgttgagca gcacctgacg
    13441 gcacgggcct tcgcgcaggt cgttgtcgac ccaatgccgt tcggcgagcg cggccagcgg
    13501 cacttccggc agcccggcga gcgggtcgtc gaggcggacg accgccaggt aggggtcctc
    13561 ggccagccgg tgcacgacga ccgacccggg gtgctcggcc ccggtttcct ccacgaagat
    13621 gtcgatgtcc gggtcgccct gcgtgaattc ggtcagcatc aggtccaggc gcaggccggg
    13681 gaattcggtg cgcagcgcgg cgaccgtcgg ggccagccag gtcgagcctg ccgagccgaa
    13741 gtagccgatc gacaggcggc cgacgcgtcc ggcgcgcagc tcgctcgcca cctgctccac
    13801 ccggctgaac gcctcgaaga gcgcctcggc ctcggcggcg agcgtgcgcc cggcctcggt
    13861 gggctcgatg ccacggccgg accgttcgaa cagctgcagc ccggtctccc gttgcagcgt
    13921 ggtgatttgc tggctcaccg cggacggcgt gtagccgagc gctgcggcgc tcgcgcggat
    13981 cgaccctgac gcgacgactg cgcgcagcac gcggagccgg ggaatgtcca gcatacggcg
    14041 aatgtacagc actccttaac ggaggtacag aactcatcgc ttgtgctgta cagctgaccg
    14101 aggcgacgat ggccaggtga ccgatctcgt ggaaaccgcc ccgcccgccc gcaagaccga
    14161 cttcggcaag atcgcggccg ccgcggggct tgccgtcgtg ctgtgggcct cgtcgttcgt
    14221 cgctatccgc agcgttgggc acgcgctgtc cccggcgccg ctggcgttgc tgcggctcgc
    14281 cgtcgcggcc gtcacgctca ccgtgttcgc cgtggccaag ggcgcggtcc ggatccggct
    14341 gtcgcgcaag gcgttcctgc tggtcgcggc atacgccgtg ctgtggctgg ccgcgtacac
    14401 cgtcgtcctc aacgcggggg agcggcacgt cgacgccggg accgcggcgt tgctggtgaa
    14461 cctcgcgccg ctgatggtcg ccgtcgcggc cgggaagttc ctcggcgagg gcttctcgcg
    14521 ctcgctcgtc gtcggctcgc tcgtcgcgct gggcggggcc gcgctgatcg cgaccggagc
    14581 caccgggagc aacgactggg ctggcgtgct gttgtgcttg ctggccgcgg tgctttacgc
    14641 cgctggcgtc atggtccaga aaatcacctt gcgccatgtc gacgggctga ccgcgatctg
    14701 gctcggctgc gtcgtcggca ctgtggtcct gctgccgtgg acaccgcagc tggtcagcga
    14761 actgcaggtg gcccccaccg gggcggtgct cggcagcgtc tacttgggag tgttccccac
    14821 cgcggtcggc ttcacggcgt gggcgtacgc gctccgccgc acggacgcgg gccggttgac
    14881 gatggtgacc tacgccgtgc ccgcggtggc cgtgctgctt tcctggctgt tgctcgcgga
    14941 aaccccgacc gcgtacggac tcgtcggcgg cgtgctctgc ctggccggcg tggcgatctc
    15001 tcgccgccgt taacggcgtc cccaccccga cacgagggga taggaggaca cggtgaaccg
    15061 cggatcggcg agcacccggc ggaactgctc gatctcctcc ggcggcacgc cgtccgcggt
    15121 cagcttttcg gccagttcca ccgaattcgc ggccagcaac cggatttccg gcccgccgcc
    15181 cggccaccgg gtcgtgctcc gcgcgctgcc gacctcgcgc aatccggctc cggcgagcac
    15241 ctccggcaac tgcccggccc attcgacgtc gctgcccgcc cgttcgagca ggtccaggat
    15301 ccggccttgc acggaacgga aaatcgtcgc gctcgcctcg tcgggcgtct ccagcacggt
    15361 ttgcccgcgc ggctcgattt cttcgaggac cagccagccg ccgggggcga gcgcgccggc
    15421 gagtttcgcc accagttcgt ctcgctccgg gaagtggatc agcaccaggc gggcgtggat
    15481 caggtcgaat tcccggtccg gcaccggctc cgcgcggacg tcgtggcgca ccgccgaggc
    15541 gttcgcgggc aggtcggcga gcaggcgcgt gtcgaggtcg gtggccagca cgtgcccgtc
    15601 cggtccgacc tgctcggcca gccgccgggc gaccgatccg ccgcccgcgc cgagttccca
    15661 gcaggaccat cccgcgccga cgccgagttc ggccaggtgc cggaaagtcg tcgtgtcgta
    15721 gctggcttcc agcgcggaca tccggtcgct cgccggggcg ctcgcgttgt cgaacgggta
    15781 ctcgtcgtcc attccgccac cctgccagca tccgcgcggc ggtgctggca ggatgacgga
    15841 agtctcagca ggtcgcgcgg acgtagccgg attcgccctg cggcgtgacg tcccggtccc
    15901 gctgcacgac gctgagggtg gcgccccatt tggcgcaagc gttgcgcaag ccgtccgggg
    15961 tgtattcgat gacgatcacg cggtcgccga aatactgggt gtattccgcg cagttgtcct
    16021 gctcgccgca ttcctcggcg acggcgaagt cgagcccgtt gccgacccgc gacgaggaga
    16081 gttccgaagt gttcttctgg gcgatcgcga ggcctttccc gtgtgcgcgc tgggaaagca
    16141 gcttgacgag gtcctgggcg ttccgtgcgc tgagcaggcc ctgggaccgg gtgaagctgt
    16201 cgtagttgtc cggctcgatc gcctggtagc ccttgcccgc gcactcgtcg atccagccgc
    16261 cgaccttgtc cgcgatccgg ctccgcttgt ccgcggtgcg caggtcgagc agcgcctcgt
    16321 tccagtcggg atccaggacg acgtcgccgt tggcgtcgcg caggaccagg tcgccccatt
    16381 cgccctcggc tccgggctgg gcctggaaag cgttgacgta gcagatgttg tacaccccgg
    16441 cggcggccgg ggcgccgtgg tcgcggctga cgacctggac gcccgccggc ggctggtagg
    16501 ggccgccgat ctggtagtcg aacccggcgt gcggggcggg cagggcgact tggctgtgcg
    16561 gggcgggcag cggggcgctt tccgccgggc cggcggcccc gagcgcgcac gccgaactgc
    16621 cgatcagcac ggcggccgcc gcggtcgcgc gagaaatccg accaggaagc gaatgcatct
    16681 ggtgactcca gcgatggtga gtacggcccc gcctcggagg ttccgaagac atcctggcga
    16741 ctgggtccgg gctcgcgggg agatccgcat taccggctgg gcgtacttct ggcgcctgcc
    16801 cgtccggcag gcgccagaag tttagcggat caccgcgccg cgccgtcaag actcacgagc
    16861 tgcccagtgt tttccgcaat cccggctgaa gcgcgtcgcc gtgcgcgagc accatttcgt
    16921 cgcacagttc ccagatgcgt tcgaccggaa gcgccgccgc cgtcgcgggg tcggtcatcg
    16981 cggcgtggcg gatgtgccgg ggatcgtcct cgaccgccgc gcgcaccacg agttcggtgg
    17041 tgctcaggta agtgcggttg agcgcggcca gctgcggcgg aagcgcgtcg acgcgcgtgg
    17101 ggcggatgcc ggtggcatcg gcgaggcacg gcacttcgac ggctccggtc gcggggagat
    17161 tcgggatcag cccgcggttg agcacgttgc cgtaaacggt gcgcggcgtc ccggtgacga
    17221 cactgtggat gatttgcggc gcgtattcat tggtgccctc gacggtgagc ggttcgtcgc
    17281 gctcgatcgc ctggcgggtg cgttcgtatt cggcttcgtt ctccgccacg acgtccagat
    17341 acgcgccgat cggcagccgc agccgttcga tttcgctggc gtggccgaga taccagggca
    17401 cgtattccga agaatgctcg ctggtttcgg tggggtagta gccgagccgc cggaacatgt
    17461 cgaaccgcac gcgccgccgc agctgcgggt cctcggagag ttcggcgagc cgcgggtaca
    17521 gatcggcgcc ctggtgctcc agccgcagga tccacgcctg gtggttgatg cccgcggcgt
    17581 ggtaggtcac ctcgggcagc ggcacttcca gcagtttggc caggtcgtgc acggtccagt
    17641 acaccgaatg gcacaggccg gccacgcggt ccgggccgag cgtttcggag aggtactgca
    17701 cgttcatcgc catcgggttc gtgtagttca gcagccacgc ccgcgggcac acctgcgcga
    17761 tgtcctcgcc gagttcgcgc aggaacggga acgtgcgcag ggcccggaag atcccgccga
    17821 cgccgagcgt gtcgccgatg gtctgctgca cgccgaagcg cgcgggaatg tcgaagtcga
    17881 cgcgggtggc ttcgcccatt ccgatttgga ccatgttgac gacgaagtcc gccccgtcaa
    17941 gggcctcgcg acggtcgagg tgcgcggtga ggacgggctt ggcgccgcgg gcttcggcga
    18001 tgcggccggc cgccgcgtgc gcgatccgca ggcgttccgg gtcgatgtcg tgcagcgcga
    18061 cgtgcacctc ggccaattcg ggataggcga acaggtccgc cagcagaccc tgggtgaaca
    18121 cgacgctgcc ggcgccgacg aaggtgatct tggtggtcat gcactttccg tttcggtgag
    18181 atcgagttcg ttccaagtgg gttggccgtc gatcccgccg cgcgcgagcg tcgaccggcc
    18241 gccgccggcg accccggccc gcagcgcgtc gcggagcggc agcccgcgca gcgtcgcggc
    18301 caggaacgcg gcgttgaagc tgtccccggc gccgacggtg tcgagcgggg agatcgggga
    18361 cgcgggaacc gtcacggttt cgccgcggtg gtgcgcgaga gcgccgtcgg caccgttctt
    18421 gacgacgacg gtcgggcctt gtgcggcgag gtgcgccgca gcgtcgagca ggctggattc
    18481 tccggacagt tgcagcgctt cggcggcatt gggcaggagg aagccggtct cctgaagtac
    18541 cagcttgatg ccgctgggat cccactgccg cgctgggtcg tcgttggtgt ccagcgacgt
    18601 ggtcgcgccg tgcgcccgtg cggtacggaa cagttccggc agcccggcgg ccagcttggg
    18661 cagcaggaag tacgacgagg cgtggacgtg tcgcgcgttc gcgagcagct cagcggggac
    18721 gtccgcggcc gacaccgcgt ccagcactcc ggagctggtg acgatcgccc ggccgcctcc
    18781 gcgggtcagg atcgcggtga gcggggtcgg cagcgtcgga tccaccgtga gggcttgggt
    18841 gtcgacgccg cggccgtcga ggaggtcgcg gacgaagcgg ccggcggcgt cgtcgccgat
    18901 ccgcccggcg aaggcgactt tcagcccgag ccgggcggca ccggcggcgg tgatcgcggc
    18961 ggacccgccg agcgtgatgc agccgtggcc gacgaggtgc tcccgttgcc ggaagtcgag
    19021 gtcttcggtc agcggaccga ggacgacgtc ggggttgacg tcgccgagca cgagcaggtc
    19081 gaagcggtgc ggcatgcgtg gttcctctgg acgactcgtc agcctttgag gccgctggag
    19141 gtgatggact ggatgaacgt cttctgcgcg ccgaggaagg ccagcagcac cggcagcacg
    19201 gtgatgacgt tcccggccat caccgcggcc cagttggtgt ggtgctgtcc ctggaaggtg
    19261 gtcaggccga gctggagcgt gtactgggtg tcgtggttga tcgcgatcaa cggccaggtc
    19321 aggtcgttcc aggtgctgag gaaggtcagc acggcgacgg tgctcagcgc gggccgggac
    19381 agcgggagca cgatccggat cagcacccgc agccgcgagc agccgtcgat ccacgccgct
    19441 tcttcgagtt cacgcggcag cgacaggaag aactgccgca gcaggaacac cgcgaacggc
    19501 gtgaccagcg acgggacgat cagcgcgccg agcgagtcga tgaggccgag cttcttcatc
    19561 accaggaacg tcgggatcat ggtgagctgg aacggcaccg ccatggtcgc catcatcagc
    19621 ccgagcatcg ccttcgaacc gcggaaccgc atgcgcgcga acgcgtagcc gccgagcgag
    19681 ccgaagacga ggttggccgc cacggtcacg accgacacga tgagcgagtt ggtgaaccag
    19741 cgcaggaaca gcgcgttctc cagcacgtac cggtagccgg agaaatcgat cccggacggc
    19801 cacagcgacg gcgggaaccg gttgatctcc gcgttgctca tcaccgagct gagcagcagc
    19861 cacaccagcg gcgcggcgaa cagcaacgcc agcggggcca gcagcagatg ccacgggctg
    19921 aacggcagcc gccagcgccg gggctggcgt gccacctcgg gcagccgggc ggcggaaacc
    19981 ggggcgacgt gggcgcgcgt cgtcatcgaa cctccttggt gcggcgcagc aaccggacgc
    20041 ccagcccgag cgccagcagc acgacggcga gcacgtaggc cgcggcggcg ccgtatccgg
    20101 cggtgaaatt ctggaacgcc tgctgccaga tgaagtagac gatcaccgtg gtcgagccga
    20161 gcggcccgcc cttcgtggtg acgtaagtca gatcgaacac ctgcagcgat tggatcagct
    20221 gccacagcgt caggaacgtg gtcaccggga gcaccgcggg cagagtgacg tgccgcagga
    20281 tgcggaacgg gccggctccg tccaaacggg cggcttcgat cagcgacggc ggcacgtcct
    20341 ggagcgcggc caggaagacg accatgcaga acccggtgcc gctccacagc gtgatggcga
    20401 ccaggaccag caacgcctgc gccgggtcgg tgagaaaccc ttgcgggctc aggccgatcc
    20461 ggtgcagcag cgagttggcg acgccgaact ccgggtcgag gatgaacgag aacaggacgc
    20521 cctgtgcggt ggccgagagc acgaacggaa cgaacatcaa cgtccggtac acgccgatga
    20581 agcgcactcg ccggttcagc gcgagcgcca gcgcgaggcc gagcacgatg ctcagcggaa
    20641 cgtataacgc cgtgtacagc agcgtgttgc cgaccgcttg gccgaagtgc gggtcctgtg
    20701 cgagcgccgc gtagttgtcg acgccgacga accgggacgg ggtgaccagg tcgtcggcct
    20761 ggaacgacag gacgagcgac cacaccacgg gcaccagccc gaggccgatg atgacgacga
    20821 ccgaggggct caggtaggcc caggcggcgg cggtttcgcg gcgtcggcgg gtcttggcgg
    20881 ccggagcgac tgtgatcggg ccgggatgta cggacatggg cggggtccta tcgggggatg
    20941 atgagggcgg cgttggccgc ggaggcgcag tcgcgcatgg cgtcggcggg ggtcgcgcgc
    21001 ccgagcagca cggagacgat cgccgcggcg acggcctgcg aaacctgcgg ataggcgggg
    21061 tggttcgcgc ggacgtgcga gttctcgagc gactcggcga acacggaaag ccccgcggtg
    21121 tcccgggttt tccgctgcca ttccggaagc cgctgcgatt cggcgctcag cgggaggctg
    21181 cccgcgccga cgtcccagac gacgtcctgg ccgggcgcgg tcagccacct caggaacgtt
    21241 ttggccgcgg cgaggcggcg gtcgccgttg tcgaagaccg tccaggtgtc cggtccggag
    21301 atggtgatcg gctttccggt gaacgtcggc agcggtacga cgtggtagtc gatgcccgcg
    21361 ccgaggatgt cgggcagttg ccacgggccg gtcggcacca tcgcgatccg gcccgaggcg
    21421 aaggcctggt acatctgctc ggagccgggt ttcgggtcga tgtagacact gcggtcggcg
    21481 gcgagtttcc ggatcacttc gagtgcctgt actccgctgt cggcgaagcc gatgctgcgc
    21541 ccgtcctggc cgacgatggt gccgccgagg tcccagatca tcggccacag ccgccagacg
    21601 gtgtcctcgt cgcccgcgcc gggccaggcc gtgccgaact gtccttggcc gcggttggtc
    21661 agtttcttcg cggtggccac gaaatccggc cagcgccagg aggcgtccgg cagcgggacg
    21721 ccgtgctgct ggaaaagttt cctgttgcag gcgacggcca gcgagtcgag catcgcgggc
    21781 accgcgcgga cgcgctcgtt gacggtgacc gcttcgagcg cgggtttcca gaactggccg
    21841 tggacgacgt cgcccatgtc ggccacgcgc gggctgcggg cgatgctggc gaggtcggag
    21901 ccgaagatgt acgcgatgtc cgggtaggag ccggacgcga gcgccgcggt gaccttctgc
    21961 agcatggcgt cggcgagcac gccgccgccg aggtcgatcc ggatgccggg gttctcgcgc
    22021 tggaacgcgg cgacgagttg cttgaggact ttgagaccgg tgtcgctctg gccgtgccac
    22081 atttcgacgg tgaccggccc ggacgtggcg gcgggggcct cggcgcaggc cgcggcggcg
    22141 ggcaccagcg ccatcgccgc cgcgccgcgg agaaaaccgc gccgggtcag ggttcgcacg
    22201 cgcatgggtt tcgttttcct tcccttgcgc tagcggggac agggggaggg agaggtcatc
    22261 tgcggtttcc ttccggcggg cagaagtggg cggctacctt ttcgggcagg ggagggacgt
    22321 cgatcggcac ggagccggaa cgcagggatt cagtggcgag tgcgcccgcc gccacggctt
    22381 cgcgggcggc gatcggcgac agttccggcg ggtcgccgtg cactgcgtag cgcaggaatt
    22441 ctttcatggt gaggagatcc gcgtcctcgt gtcctgatgc gacaccgtcg atcgggtact
    22501 cgcggtcgcc gtctcgggcc caattgcggc ggcgg
//
