LOCUS       NZ_CP091381            20684 bp    DNA     circular CON 18-AUG-2024
DEFINITION  Amycolatopsis sp. FU40 chromosome, complete genome.
ACCESSION   NZ_CP091381
VERSION     NZ_CP091381.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. FU40
  ORGANISM  Amycolatopsis sp. FU40
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 9944196)
  AUTHORS   Reisman,B.J. and Bachmann,B.O.
  TITLE     Biosynthesis of Apoptolidin Family Glycomacrolides
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9944196)
  AUTHORS   Reisman,B.J. and Bachmann,B.O.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-2022) Chemistry, Vanderbilt University, 1234
            Stevenson Center Drive; Room 7330, Nashville, TN 37235, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 23-JAN-2022
            Assembly Method                   :: Flye v. 2.9
            Assembly Name                     :: NFU40_flye_2.9
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 47.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_021903635.1-RS_2024_08_18
            Annotation Date                   :: 08/18/2024 04:30:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,491
            CDSs (total)                      :: 9,417
            Genes (coding)                    :: 9,360
            CDSs (with protein)               :: 9,360
            Genes (RNA)                       :: 74
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 57
            CDSs (without protein)            :: 57
            Pseudo Genes (ambiguous residues) :: 0 of 57
            Pseudo Genes (frameshifted)       :: 7 of 57
            Pseudo Genes (incomplete)         :: 50 of 57
            Pseudo Genes (internal stop)      :: 5 of 57
            Pseudo Genes (multiple problems)  :: 5 of 57
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:13:09
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 962993
            Orig. end                         :: 983677
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP091381.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Brian O. Bachmann,
            Vanderbilt University.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20684
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="CDPS"
                     /region_number="6"
                     /rules="CDPS"
                     /tool="antismash"
     cand_cluster    1..20684
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="CDPS"
                     /kind="single"
                     /product="CDPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20684
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="False"
                     /core_location="[10000:10684](-)"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10684)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
     gene            732..1649
                     /locus_tag="L3Q65_RS05700"
                     /old_locus_tag="L3Q65_05700"
     CDS             732..1649
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="L3Q65_RS05700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="L3Q65_05700"
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_182892015.1"
                     /transl_table=11
                     /translation="MAEIAPLDRQLRGLLRHGTFAQVLDHALNVRGLSLEQVRQRLAGR
                     GVRVSRAALSYWRHGRSRPERAESLRAVRALEAVLGLPPESLVALLGPPRPRGRGAAAE
                     PEAIDRKRLWPGHRPLLAELNLPPDNLVRRLDVHEHLRVDEHRRLTKVHTRLVVEATAD
                     RVDRCVVFLWAERSAPALPAEVRYCRPGRVRVDPEAGATVCELLLDQRLATGERSVLEY
                     TAVYPPGPELTFYHHRFTRPVRQYLLQAEFAGAPPATCVPFRQNSVQAPRRPGPPLWIG
                     ASRTAHLVLTDVRPGIAGLAWEWA"
     gene            complement(1693..4992)
                     /locus_tag="L3Q65_RS05705"
                     /old_locus_tag="L3Q65_05705"
     CDS             complement(1693..4992)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015100352.1"
                     /locus_tag="L3Q65_RS05705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_05705"
                     /product="protease pro-enzyme activation domain-containing
                     protein"
                     /protein_id="WP_237598955.1"
                     /transl_table=11
                     /translation="MLPRSLWARPAAAAAGLVLTAALAIPGSAAAQEPRTPLAPTGSAP
                     AGAQRLGATDPGREIPIALSLRPHDEAGLAQFVASVSDPRSPDYRHFLSSADYTARFAP
                     RESDVDAAKAYLEKQGLRVTDVSANRQVVDAAGTVEQVEAAFGTRLGDYADSAGKHFYA
                     RESAPSVPSSVAKIVRTVTGLTNRPIAHRASSPAGPGGPGGGYTPAQFRTAYSMKQLSG
                     SYDGSGQTVGLIEFDSFKQSDIDAWTNYFKQPAVKPKAVPVDGGVSQPGSGQLEVTLDI
                     QAVAATAPGASQIVYEAPNSDKAWVDEMAKIASDNEITILSGSWLLGEKCESDPIAASH
                     DSYSQMVAQGVTLLSASGDWGATGCGYNGDNSTVQADYPASDPLFTGVGGTQLRTSDSA
                     GTYQSESCWNQGGTGNTRSGGGYSAVYGKPDWQPGSSKYRSVPDVALDADYGAGALSVY
                     MNGGWQDVGGTSLSSPLWAGYLAMVNQKAKSSGKSNLGAINPTVYSIAQSAQYSSAFHD
                     VVSGNNGTYDAGTGYDLCTGWGSMQGDNLADPLINGTTPPAANDFSLAADPASVSVDPG
                     KSATTKITTKVVKGSAQSVALSASGLPAGVTATFDPPSVTAGGTSTLTLAASSSASPGQ
                     NTVTVTGKATDATHTTPVALTVNGSGQGDFSLSVDPTSASVNAGQSATTTVSTTAVNGA
                     APSASPSVINGQPTTVAKYPFIISEHRTGGVRPQEQSCTGSVVAKRAVLIAAHCKFADG
                     DPKYLIYGRDDLNDTSKGTRIEIAEFRIHPDYSPQSDQGWRNGNDVAIIFTKTDIPVPA
                     GMTYPKIASSADDLPLGTQGTAIGYGKTDANDAGKNTQLREVVLPTVDGSNCSTIDSSV
                     FKPQYMFCDGYGDGSKGLCQGDSGGPYYYNGKIYGVFSWLRTDCASYNAHGKLWGSMGD
                     WANQQIGATPPSGGDIALSASGLPAGASATFDPASVNAGGSAKLTIATSASTPQGTYKV
                     TITGKNATASHDTTFTLTVQGGSSGPVTVADPGFQAVPHGSPVHLAMRASGGTGSYSWS
                     ATGLPSGLSIDHATGVISGNPQTTSGLLSSTITATDTSGTAGKAQVSWFVY"
     misc_feature    complement(5136..5150)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.17"
                     /tool="antismash"
     misc_feature    5137..5148
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.47"
                     /tool="antismash"
     gene            complement(5168..6328)
                     /locus_tag="L3Q65_RS05710"
                     /old_locus_tag="L3Q65_05710"
     CDS             complement(5168..6328)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099806.1"
                     /locus_tag="L3Q65_RS05710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_05710"
                     /product="MFS transporter"
                     /protein_id="WP_237598956.1"
                     /transl_table=11
                     /translation="MDVTAPPGRTALPLPALLALAASVFLGCLTEIVPAGILLPAAADL
                     GVSPAAAGQLVTVYAITTALTALPLTAASARMPRRKLLLLLVAGFVAANLAIALSPWFA
                     LVLAARVASGALTGILWSLVANYAMRLVPAERSGRALAVAMAGTPVGFALGVPAGAALG
                     ELVGWRWVFAGMALVAAPLLWWIVAVVPPLSGEEPGARTSLRAVLRTPGLRPLLLLVVA
                     FSLAHNMFYTYLGPFYAAHGHLVLLSAGLLLFGTATVAGLWLVGLALDRHPRAVLTCCA
                     AVTAGCFGMLVFGGREPVLLLAACALWGLAFGGAPTSFQAVTAVLAGRRADIAQSLTIA
                     SWNGAVAGGALIGGVLLGTAPGALPWTAIALTVVPVLLSSFVLPAR"
     gene            complement(6616..7779)
                     /locus_tag="L3Q65_RS05715"
                     /old_locus_tag="L3Q65_05715"
     CDS             complement(6616..7779)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012311.4"
                     /locus_tag="L3Q65_RS05715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_05715"
                     /product="S8 family peptidase"
                     /protein_id="WP_182892012.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 5.2e-27, bitscore:
                     93.9, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRTPKAVVLAALLSLAAGIAAPAAVADDTAVYIVRLKPMDKDKD
                     KVTAAANALIAKYGGTLRRVYYSVSQAFSLSATREQHDKYLTDAAVTTVGANQVYTAAG
                     TQEDPPSWGQDRIDQTDLPLDGSYTYPNTAANVHVYVLDTGVRTSHHDFGGRAHAAYDA
                     VDPDDDQSGTDCNGHGTQVAAAIAGSRYGVAKEASVESVRTLGCDGTGTSEEILSALDW
                     VNLNAQRPALLNLSFAGPSGTVLDIQLYKMTQNGLSYTVAAGNGDGSTGVNACDITPAR
                     QTTGITVGATDQADHRAPSSNFGSCVDLYAPGKDIPTADNTGDCASAVVSGTSIASAEA
                     AGVAAMFLSAHPDATPDQVLKGMTDAAAKDKVVDPGEGSHNLLLHTT"
     gene            complement(7841..8311)
                     /locus_tag="L3Q65_RS05720"
                     /old_locus_tag="L3Q65_05720"
     CDS             complement(7841..8311)
                     /GO_process="GO:0061077 - chaperone-mediated protein
                     folding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012314.4"
                     /locus_tag="L3Q65_RS05720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_05720"
                     /product="co-chaperone YbbN"
                     /protein_id="WP_182892011.1"
                     /transl_table=11
                     /translation="MGTRIRMFAAVAAMTAGVLGGAAATPASAAQTPASYASLAPQDET
                     VVDVTSANYDQVMEMSKTKPVVLDFYASWCGPCQKMAPYLEKYHAADGGKWIWAKVDLS
                     EQGQNKDIADKYGIEYIPTLIDISAGQEKGSRVVGFDEGSGPDDLRTWLNNL"
     gene            complement(8322..8723)
                     /locus_tag="L3Q65_RS05725"
                     /old_locus_tag="L3Q65_05725"
     CDS             complement(8322..8723)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020670318.1"
                     /locus_tag="L3Q65_RS05725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_05725"
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="WP_237600852.1"
                     /transl_table=11
                     /translation="MLPLIGREELKTAMDEGTVIVVDTMPPDYYAREHLPGARNIPGFP
                     YEQAARFTDEHAPRVVPDKTAAIVVYCANTPCRNSEFVGARLLELGYADVRKYREGIED
                     WVGAGHPTETGPAPETPARPAPVPVTHPE"
     gene            complement(<8871..10004)
                     /locus_tag="L3Q65_RS05730"
                     /old_locus_tag="L3Q65_05730"
                     /pseudo=""
     CDS             complement(<8871..10004)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014218.4"
                     /locus_tag="L3Q65_RS05730"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_05730"
                     /product="cytosine permease"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNDRHDDYSLTRVPDAARRSWPSVAVQRFGQVSSFQQFIVGALLG
                     YGMTFWNAVLAITIGSVLLEVITVLLGIAGVREGLSTSVLARWAGFGRKGSALVGLLVA
                     ISLAGWFGVQNGVFAHGMHALGGALPEWGWALVGGAAITVITVYGFRLMAWTAYLTVPA
                     FLVLAGYSVLDALHTHSLADLVAAPPPGPPLSLGAATTLVSGAFILGALMTPDMTRFNR
                     TRADVVKQTVISVTLGEYLIGLIGVLLAHAAATSDVVGIVTSSSGLLGTLVLATAILKI
                     NDWNLYSSSLGLVNVVDVLFDRKVSRVHVVLVLGVFGTAASALGIADDFAGFLTAVGVL
                     APPVAGVLIAEYFVLRRCRPVFAALRRGQAVAGRDWEL"
     gene            complement(10001..10684)
                     /locus_tag="L3Q65_RS05735"
                     /old_locus_tag="L3Q65_05735"
     CDS             complement(10001..10684)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) CDPS:
                     CDPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009082649.1"
                     /locus_tag="L3Q65_RS05735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_05735"
                     /product="tRNA-dependent cyclodipeptide synthase"
                     /protein_id="WP_237598957.1"
                     /sec_met_domain="CDPS (E-value: 4.9e-62, bitscore: 208.5,
                     seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFDATPLSSGCARLYPDVRHACVGVSPFNGYFTAERLARLAAWTA
                     DRFAEFCFFVPDEVTAYTLEALGYPPARAKQKAHRQSCHVHNKIAAALRALDVPDPESR
                     ILGMARLRELPSYRELLASAETHFETDSAFRSACYGASTWVLQGRTGNVPDEQALRLAV
                     RYFLAELPLFAGSGLITGNPRSMFVYHQRVPFLEKFFDREFAFRPEPGQGFLVVAEAAL
                     EATGR"
     gene            11004..11957
                     /locus_tag="L3Q65_RS05740"
                     /old_locus_tag="L3Q65_05740"
     CDS             11004..11957
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015431.4"
                     /locus_tag="L3Q65_RS05740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_05740"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_182892008.1"
                     /transl_table=11
                     /translation="MELELKHLRHLQAIAQAGSLNRAATELVLPQPALSRELRRIEELL
                     GRPLFERARAGVRPTPFGQLILDYADGILARTARIGPALAQHRAQRDSALRVGWSETVL
                     SGPLLRALETTGLGDRAEIRTAESTAEMLVWFGRGELDLAVLSEQCEVPLPANTGRIDL
                     AEDPLLMMLPDWHPLAARREVDLAELEHERWISSTGPDRCREFLARVCGPYGFAPVIAH
                     YVPVSGPRDEIVRYQGDVTLVQASRPLAPGVVHRPVPGLRERTRHFLLYREDSPVAARA
                     GLLAGLILDAYHDERGGYDGPRAIPGELPWLTARTS"
     gene            11933..12877
                     /locus_tag="L3Q65_RS05745"
                     /old_locus_tag="L3Q65_05745"
     CDS             11933..12877
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015431.4"
                     /locus_tag="L3Q65_RS05745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_05745"
                     /product="LysR substrate-binding domain-containing protein"
                     /protein_id="WP_237598958.1"
                     /transl_table=11
                     /translation="MADRPDQLIRTGTDLELRQLKLLVAVAEAGSVAAAAAALGTTPAK
                     LTLRIRRLERMIGAALLAAEPAGKLFTETGEVLLEHASAVVPQFDRMLTAARAGLERPV
                     AQIRIGSVPTPVLPRLIREVGLRNPGAGLAVRTGESAAELAEALLRAELDLGLLRQDAV
                     RERPLEWVSIATEPLVVGIPPGHPLGVPDSLTPAALSGRRCVLLDQAVQPRTHALLAAF
                     ADAGADPRLCYADSEWAVLCVGYGAGILTVTAPPTRPMPDTSYRPLHCAATNSTLVLAW
                     AEDSPFAGCVPRVRAAMTRAHAESLRALVSCRP"
     gene            complement(12933..16304)
                     /locus_tag="L3Q65_RS05750"
                     /old_locus_tag="L3Q65_05750"
     CDS             complement(12933..16304)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020496093.1"
                     /locus_tag="L3Q65_RS05750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_05750"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_237598959.1"
                     /transl_table=11
                     /translation="MAATGSLVLAGATQPAQAAAPAAAADTAPQSVIVVLADQLPSAPP
                     TKAASDTRRAKATQEQDSVLAKLAGAAPAKVKHFALGNAFSATVTPAQAAQLAHDPAVA
                     QVLPDSKVTLPDAKPGAPAAAPKAGGPSAPASPNATCPADPAKPLLEPEALTSIRAYST
                     TGGKSASDLANGAGVKVAFLADNMDPNYADFIRPDGSHVFSDYQDFSGDGPNTTDAGAE
                     AFGDASSIAAQGVVVHDLSKFVNEKHPLPAGCNIVVKGVAPGASLVGLNVFGKTATNSA
                     VLQAIDYAVTVDHVDVINESLGLNQYPDSSSRNLFQVFNDQAVAAGVTVTASSGDAGTT
                     STIGSPATDPLVISTGATTDNRLYAQTGYAAFPFSNGKWVSDNISALSSSGITQNGRTI
                     DLVAPGEGNWADCSPAYSECRNFNTVPQPTDLESFGGTSESAPLTAGVAALVIQSYRNS
                     HHGTSPTPAQVKQIITSTARDLNLPADEQGAGLLDARAAVEAALTAPGSTGAPAGVSSN
                     ISLSADQLTLEGAPGSTQQASVNVTNSGTKPLTVSTGTRTFSPMGTQAQTTAFDSTKLP
                     TFPYFNGTNWAYKKVTFSVPNGAQRLLARMAWQGSPKSVNGQSVTPVVRLTLLAPDGTF
                     VANSRPQGGAATANYANVDVTRPAAGTWTAVLYSASGQAGYTGDVQLATTAQRAVPYGQ
                     VSPQILQLNPGQTKPVHVALQTPASGGDADYSITFGSSDGHQTTVSAVLRALIPTKNGP
                     GAFSGTITGGNARAVSPAQTFSYEFDVPRGKRDLDVAVKLQDPGTLLDGVLVDPNGELA
                     DVNSNASLDSATTLKQGTGLQLVDANPLPGRWHLVLVVQNPVTGKQIDQPFTGTVGFDQ
                     VSVGAPALPQSASLAAGKAVTVPVTVRNTGVEPLAIGVDARTNTRQTLQPQPIQGSTEV
                     NLPELNSDAPVYSIPPETSKFTVATSSTVPAQAEIQGSAAGIDVLGDLKSAQNGSTVSV
                     ATIGEKTGYVTKGVWFADVQEIGPFGPEGAPAGHSSYTASIQTAGFDGSVTSSTGDPYG
                     QSVDPNGTGGTPQLVKPGETATILVTITPSGDRGQKVAGHLNIVTVPSLPTGVTGLPQV
                     GTGEVLATLPYSYRIG"
     gene            complement(16548..17765)
                     /locus_tag="L3Q65_RS05755"
                     /old_locus_tag="L3Q65_05755"
     CDS             complement(16548..17765)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076587.1"
                     /locus_tag="L3Q65_RS05755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_05755"
                     /product="MFS transporter"
                     /protein_id="WP_237598960.1"
                     /transl_table=11
                     /translation="MTTTADPLPDTPETTTRPAWFPAAAAVFAAGWGGNQFTPLLVMYH
                     AAGYSAFTVDALLGAYVVGLVPGLLLSGGLSNRYGRRPVMFAGTVLSLLASVLLALGPA
                     GAGWIAAGRFLSGIAVAVAMAVGSTWIKELADADPYSAADTGTRRAALCLTLGLGIGPG
                     VAGALAQWGPWPMVLPYLVHIGLALVSLLAVTRSPETLAVRTGSVRAALPATARHPRFR
                     RVILPAAPWIFGSCGVAYAILPQLVEHQTGSWALAYSTLLTVCAIGAGVGIQPIAKRVD
                     RATSARAVLTGMAVLCAGLVLSVFAAAEESPWIALGAAVVLGAAYGIVVVSGLLELQRL
                     ARPDEIAELTGVYYALAYVGFLLPSLLAALNAVAGYPVLLACVALVAIAGTLVVTRHSR
                     RHLPQD"
     gene            complement(17762..18400)
                     /locus_tag="L3Q65_RS05760"
                     /old_locus_tag="L3Q65_05760"
     CDS             complement(17762..18400)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076589.1"
                     /locus_tag="L3Q65_RS05760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_05760"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_182892004.1"
                     /transl_table=11
                     /translation="MNASKPAADRAYELTKELVLTGELPGGHLFSEGEIAERLGVSRTP
                     VREAFLRLQVEGLLNLIPKRGAIVVPITPGEAEDVLEAREAVESAAVQRLGRRPELIPA
                     ALEQLRAVLDVQRQHADAGDVPAFAEADALFHRTIVEAGGNALLLAFYTTLADRQRRMN
                     VHALAPIPARLPRVVGEHEDLLNIIAEAGTKADTFAPALRAHLDSVHRR"
     gene            18494..19375
                     /locus_tag="L3Q65_RS05765"
                     /old_locus_tag="L3Q65_05765"
     CDS             18494..19375
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1158: ornithine cyclodeaminase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014476.4"
                     /locus_tag="L3Q65_RS05765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_05765"
                     /product="ornithine cyclodeaminase family protein"
                     /protein_id="WP_220507324.1"
                     /transl_table=11
                     /translation="MLLLDARPTVNQAVDAIRAALTGGLDPDQDPPRSVVPVPTGQFLL
                     MPAFWDRYAGVKVASVAPDNPARGLPRIQGHYLLMDGPTLTPMALLDGVALTSVRTAAV
                     SAVAVDLLAVPDAERLVVFGTGPQAQSHIEAFRAVRPVRDVVVVGRNAERAQAFAAQYP
                     FARAGTPDDVSAADLIACCTSSRTPVFDGAKVPEHATVVAVGSHEPDAREVDDVLIGRS
                     TVVVEGIGAATREAGDVVMAMESGALAADDLVSLAALAQGAAVPPGPRLFKSVGMAWED
                     LAVAAAVYEAVK"
     gene            complement(19368..20156)
                     /locus_tag="L3Q65_RS05770"
                     /old_locus_tag="L3Q65_05770"
     CDS             complement(19368..20156)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016697888.1"
                     /locus_tag="L3Q65_RS05770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="L3Q65_05770"
                     /product="ABC transporter permease"
                     /protein_id="WP_237598961.1"
                     /transl_table=11
                     /translation="MIAAELRRLCSTRLWLWALVTAAACGGGLVGLIGVIGPQHVQPPM
                     PGLDTAAGVRNVLGMATVTVLFPAVFGTVAMTSEYRHRTISVTFLFAPRRWRILVAKLA
                     AFAIGGLCYGVVTAAAAGLALYGSAAVHGVTVGLAPGTVLELLLRIAAAMTIYTVLSVG
                     IGALLRNQVAALAVVIGYLYLVEIALLAIPGVNAIYPFLPGGATAALTEFGYLADALAQ
                     QTGHAGGQLLPTAGGALVLLGYALVAAGLAVAFPLRRDVT"
     misc_feature    20182..20196
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.45"
                     /tool="antismash"
     misc_feature    complement(20183..20194)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.69"
                     /tool="antismash"
ORIGIN
        1 cggctttcgc cgtcgtccgg acggtcggtg cgggtggcgg aagcggcgct gacgatgctg
       61 cacggggcga gtcagctcgc cgccgcggca cccggtttcg gggagccgtt caacgtcgtg
      121 cgcgcgtgcg aggcgttgcc cgcgctggga ctcgcggacg cctggccgga gccgccgatc
      181 gtgccgcagg cgaaagcagc cggggaaatc tggtctccgc cagaggtttt cgacgcactg
      241 cgggagcgtc cggcgcggat cgacggggac ggggtggtcg cggtgatcgg gctgcaccgg
      301 ctgtccgcgg tggaagaagc cttgcgcgcg gccgaagagg tcacgctcgt cgtggtgacg
      361 ggtcagccgg gggagctggt gccgttgacc aatctggtgc tggcggatct gcgtggtctg
      421 ctgaagcggt cgtgcccgga atcggcgtgg ccggacgtgc gggtgatcgt cgacgagacc
      481 ggcgcggtgg ccgccgcggc cggggtttcg gcggtcagcg acgcgaccga gaccgctatc
      541 cgcgtccaca atggacacat tctgctgcgg gcggagggct tcggcgcctg ccacgccgcc
      601 gcgacgggcg ccgtgcccgc cggatgaatc ggcggaatcc gctgccgggc cgcctaaacc
      661 cttccgacgt cggtggacag ggcagccgcc gcggcagata gtggagcgaa gatcggccga
      721 aaggagcggc gatggccgag atcgctccgc tggaccggca gttgcgcggc ctgctgcggc
      781 acggcacgtt cgcgcaggtc ctcgaccacg cgctgaacgt ccgggggctg agcctcgaac
      841 aggtccggca gcggctcgcc gggcggggag tgcgggtcag ccgggcggcg ctgagctact
      901 ggcgccacgg ccgcagccgt ccggaacggg ccgaatcgct gcgtgcggtg cgggccctgg
      961 aggcggtgct cggcctgccg ccggaatcgc tggtcgcgct gctcggcccg ccccggccgc
     1021 ggggaagggg agcggcggcg gaaccggagg ccatcgaccg caaacggctg tggccgggcc
     1081 accggccgtt gctggcggag ctgaacctgc cgccggacaa tctggtgcgg cgtctcgacg
     1141 tgcacgagca cctgcgggtc gacgagcacc ggcggctgac caaggtgcac acccggctcg
     1201 tggtggaggc caccgccgac cgggtcgacc ggtgcgtggt gttcctgtgg gccgagcggt
     1261 ccgccccggc gctgcccgcc gaggtccggt actgccgtcc cggccgggtc cgggtcgatc
     1321 cggaagccgg ggcgacggtc tgcgaactgc tgctggacca gcggctcgcg acgggcgagc
     1381 gcagcgtgct cgagtacacc gcggtctacc cgcccggccc ggaactgacc ttctaccacc
     1441 accgcttcac ccgcccggtg cggcaatacc tgctgcaggc ggagttcgcc ggcgccccgc
     1501 ccgccacctg cgtgccgttc cgccagaaca gcgtgcaggc gccgcggcgc cccgggcctc
     1561 cgctgtggat aggggcctcg cggaccgcgc atctggtgct gaccgacgtc cggccgggca
     1621 tcgcgggcct ggcctgggaa tgggcttgac cggcggtccc gggaaaccgc cggccagccc
     1681 ctccgcaccc ggtcagtaga cgaaccagga gacctgcgcc ttccccgccg tgccggaggt
     1741 gtcggtcgcg gtgatcgtcg agctcagcag acccgaggtg gtctgcgggt tcccggagat
     1801 cacgccggtg gcgtggtcga tggacagccc cgagggcagt ccggtggcgc tccaggagta
     1861 gctgccggtg ccgccggagg cgcgcatcgc caggtgcacc ggcgaaccgt gcggcaccgc
     1921 ctggaagccc gggtcggcca cggtgaccgg accggacgaa ccgccctgca cggtgagggt
     1981 gaacgtggtg tcgtggctcg ccgtggcgtt cttgccggtg atcgtcacct tgtacgtccc
     2041 ctgcggcgtg gaggcgctcg tggcgatcgt cagcttcgcg gaaccgcccg cgttgaccga
     2101 cgccggatcg aacgtcgcgc tcgccccggc gggcaatccg ctcgctgaca acgcgatgtc
     2161 gccgccggac ggaggcgtgg cgccgatctg ctggttggcc cagtcgccca tcgaacccca
     2221 cagcttgccg tgcgcgttgt aggacgcaca gtcggtgcgc agccaggaga agaccccgta
     2281 gatcttgccg ttgtagtagt acggtccgcc ggagtcgcct tggcacaggc ccttgctgcc
     2341 gtcgccgtag ccgtcgcaga acatgtactg cggcttgaac accgacgagt cgatggtgct
     2401 gcagttcgaa ccgtccactg tgggcagcac gacctcgcgc agctgggtgt tcttgccggc
     2461 gtcattggcg tcggtcttgc cgtagccgat ggccgtgccc tgggtgccca gcggcaggtc
     2521 gtcggccgag gacgcgatct tcgggtaggt catgcccgcc ggaacgggga tgtcggtctt
     2581 cgtgaagatg atcgcgacgt cgtttccgtt gcgccagccc tggtcgctct gcgggctgta
     2641 gtccgggtgg atccggaact ccgcgatctc gatccgggtg cccttgctcg tgtcgttcag
     2701 gtcgtcccgt ccgtagatca ggtacttcgg gtcgccgtcg gcgaacttgc agtgcgcggc
     2761 gatcagcacc gcccgtttgg cgaccacgct gccggtgcag gactgctcct gcgggcgcac
     2821 cccgccggtg cggtgctcgg aaatgatgaa cgggtacttg gcgacggtgg tcggctgccc
     2881 gttgatcacg ctcgggctcg ccgagggcgc ggcgccgttc accgcggtcg tcgagacggt
     2941 ggtcgtggcg gattgcccgg cgttgaccga cgccgacgtc gggtcgacgc tgagggagaa
     3001 atcgccttgg ccggaaccgt tgaccgtcaa agcgaccggc gtcgtgtgcg tggcatcagt
     3061 ggcttttccc gtcactgtaa cggtgttctg ccctggtgag gctgaggacg acgccgcgag
     3121 tgtgagggtg gacgtgccgc ccgcggtcac cgagggcggg tcgaacgtcg ccgtgacgcc
     3181 ggctggaagc ccgctcgccg acagcgcgac gctctgcgcg ctgcccttga cgaccttggt
     3241 ggtgatcttc gtggtcgccg acttgcccgg gtcgacgctg accgaggccg ggtccgcggc
     3301 gagggagaag tcgttggccg cgggcggcgt cgtgccgttg atcagcgggt ccgccaggtt
     3361 gtcgccctgc atggagcccc agccggtgca caggtcgtag ccggtgcccg cgtcgtaggt
     3421 gccgttgttg ccggagacga cgtcgtggaa ggccgaggag tactgcgcgg actgggcgat
     3481 cgagtacacc gtcgggttga tggcgccgag attgctcttg cccgagctct tcgccttctg
     3541 gttcaccatc gcgagatagc cggcccacag cggggaggac aggctcgtcc cgccgacgtc
     3601 ctgccagccg ccgttcatgt acaccgaaag cgcgcccgcc ccgtagtcgg cgtcgagcgc
     3661 gacgtcgggc accgaacggt acttgctgct gcccggctgc cagtccggct tgccgtagac
     3721 cgccgaatac ccgccgccgg agcgggtgtt gccggtgccg ccctggttcc agcacgactc
     3781 cgactggtaa gtgcccgcgc tgtcgctcgt ccgcagctgc gtgccgccga cgccggtgaa
     3841 cagcgggtcg ctggccgggt agtcggcctg cacggtggag ttgtcgccgt tgtagccgca
     3901 gccggtggct ccccagtctc cggaggccga cagcagagtg acgccctggg cgaccatctg
     3961 ggagtaggag tcgtgcgacg cggcgatcgg gtcggattcg cacttctcgc cgagcagcca
     4021 cgagccggac aggatcgtga tctcgttgtc gctcgcgatt ttcgccatct cgtcgaccca
     4081 ggctttgtcg ctgttcggcg cctcgtagac gatctggctc gctccgggcg cggtggccgc
     4141 gaccgcctgg atgtccagcg tcacctccaa ctgcccgctg cccggctggg aaaccccgcc
     4201 gtccaccggg accgccttgg gcttgaccgc gggctgcttg aagtagttcg tccaggcgtc
     4261 gatgtcggac tgcttgaacg agtcgaactc gatcagcccg accgtctgcc cggatccgtc
     4321 gtaggaaccg gaaagctgct tcatgctgta ggcggtgcgg aactgggcgg gggtgtagcc
     4381 gccgcccggg ccgccgggac ccgccgggga cgacgcgcgg tgcgcgatcg gccggttcgt
     4441 caggccggtc accgtgcgca cgatcttcgc gaccgacgac ggcacgctcg gcgcggattc
     4501 cctggcgtaa aagtgctttc cggctgagtc ggcgtagtcg ccgagccgcg tgccaaacgc
     4561 cgcctccacc tgctcgacgg tcccggccgc gtcgaccacc tggcggttgg ctgagacgtc
     4621 ggtgacccgc aggccctgtt tctccaggta tgccttcgca gcgtccacat cggactcgcg
     4681 cggtgcgaag cgggccgtgt agtccgcgct ggacaggaaa tgccggtagt ccggcgaacg
     4741 cggatcgctg accgaggcga cgaactgggc gagcccggct tcgtcgtggg gacgcagcga
     4801 gagcgcgatc gggatttccc ggccgggatc ggtggcgccg agacgctgcg cgcccgccgg
     4861 ggcggagccg gtgggcgcca acggcgtccg cggctcttgg gcggcagccg aacccggtat
     4921 cgccagagcg gctgtcagga cgagaccggc tgccgcggcg gccggtctcg cccacaggga
     4981 acgagggagc acgattcctc caaagcgaag cggagaagaa acagccggcc aaggctagcc
     5041 gcggcggggg ccgccgaatc gtgctcgctg aacgttcgac gacgttcaac cgtaattctg
     5101 aaccagggcg tttcccctgc tcagaggtag tggggtgaaa cagttttcca cagagtggcg
     5161 ggtcaattca ccgcgctggg aggacgaaac tggaaaggag aaccggcacg accgtcaacg
     5221 cgatggctgt ccagggcagc gcgccgggag ctgtgccgag caggactccg ccgatcagcg
     5281 cgccaccggc gacggcgccg ttccagctgg cgatggtcag cgactgcgcg atgtcggcac
     5341 ggcgtccggc cagcaccgcg gtgaccgctt ggaacgacgt cggcgcacca ccgaaagcca
     5401 agccccacaa cgcacacgcg gcgagcagca gcaccggttc gcggccgccg aagacgagca
     5461 tcccgaaaca gccggcggtg acggcggcgc agcacgtgag cacggcacgg ggatgccggt
     5521 cgagggcgag cccgaccagc cacagcccgg ccaccgtggc ggtgccgaag agcagcagcc
     5581 cggcgctcaa cagcacgaga tgcccgtgag cggcgtagaa cggcccgaga taggtgtaga
     5641 acatgttgtg cgccaaggaa aacgctacca ccagcagcaa cagcggacgc agccccggcg
     5701 tgcgcagcac ggcgcggaga ctcgtccgag cccccggttc ctcgccggac agcggcggaa
     5761 ccaccgccac gatccaccac agcagcggcg ccgcgacgag agccatcccg gcgaacaccc
     5821 agcgccagcc gacgagttcg ccgagggcgg caccggccgg gacgccgagc gcgaaaccca
     5881 ccggggtgcc cgccatcgcg acggcgagcg cgcggccgga ccgctccgcg ggcacgaggc
     5941 gcatggcgta gttcgccacg agggaccaca gaatcccggt gagcgccccg gaggccaccc
     6001 gcgccgcgag caccagcgcg aaccacgggg acagcgcgat cgccagattg gccgccacga
     6061 acccggcgac cagcaggagc aggagtttcc ggcgcggcat ccgggccgac gccgcggtca
     6121 gcggcagcgc ggtgagggca gtggtgatcg cgtagaccgt caccagctgt cccgcggcgg
     6181 ccggggacac gccgaggtcg gccgcggccg ggagcaggat tccggccggg acgatctcgg
     6241 tcaggcagcc gaggaacacc gaggcggcca aggccagcag ggcggggagg ggcagagcgg
     6301 tgcggccggg cggcgcggtg acgtccatgg cggggtcctt ggggtcgtgg cggtcggccg
     6361 cgtcggtcag gcgggggcgg gtgattcgtc gtcgggttcg gtgttgtggc cgcgtcggtc
     6421 atgccgtcgc ggagcacggc cgggcggggg aagtgcggcc gtgcggggtg ggtgatgcgt
     6481 cgccggtcgg tgatttggcg gccgcgtcgg tcatgccgtc gcgcggccgg gcggggagga
     6541 gcggccgggc ggcgccgtga cgtccgtggt gggggggggc cctgacgtcg tggcgaccgg
     6601 cccggccgcg cgcggttacg tggtgtgcag cagcaggttg tgcgagccct cgccgggatc
     6661 gacgaccttg tccttcgcgg ccgcgtcggt catgcccttg agcacctggt ccggcgtcgc
     6721 gtccggatgc gcggacagga acatcgcggc cacccctgcc gcttccgccg aagcgatcga
     6781 cgtcccggaa accacggcgg acgcgcagtc tcccgtgttg tccgccgtcg ggatgtcctt
     6841 gcctggcgcg taaaggtcca cgcagctgcc gaagttcgac gacggcgccc ggtggtcggc
     6901 ctgatcggtg gcgcccacgg tgatcccggt ggtctgccgg gcgggcgtga tgtcgcaggc
     6961 gttcaccccg gtgctgccgt cgccgttgcc cgcggcgacg gtgtaggaga ggccgttctg
     7021 ggtcatcttg tagagctgga tgtcgaggac cgtgccgctg ggaccggcga agctgaggtt
     7081 cagcagggcc gggcgctgcg cgttgaggtt cacccagtcc aaagcggaca gaatctcctc
     7141 ggacgtgccc gtgccgtcgc agccgagagt gcgcaccgac tcgaccgagg cctctttcgc
     7201 gacgccgtag cggctgcccg cgatggcggc cgcgacctgg gtgccgtggc cgttgcagtc
     7261 cgttccgctc tggtcgtcgt cgggatcgac cgcgtcgtac gcggcgtgcg cgcgtccgcc
     7321 gaagtcgtgg tggctggtgc gcaccccggt gtcgagcaca tagacgtgca cgttggccgc
     7381 ggtgttcgga taggtgtagc tgccgtcgag cgggaggtct gtctggtcga tccggtcctg
     7441 tccccacgaa ggcgggtctt cctgggttcc ggcggcggtg tagacctggt tggccccgac
     7501 cgtggtgacc gcggcgtcgg tgaggtactt gtcgtgctgt tcccgggtcg ccgaaaggga
     7561 aaacgcctgc gagaccgagt agtagacccg gcgcagcgtg ccgccgtact tggcgatcag
     7621 cgcgttcgcc gcggcggtga ccttgtcctt gtctttgtcc atcggcttga gccgcacgat
     7681 gtacaccgcg gtgtcgtccg cgaccgccgc gggcgccgcg atgccggccg cgagcgagag
     7741 cagggccgcc agcacgacgg ctttcggggt gcgtttcatg gtcgtccctt cggggagcct
     7801 ccgccgcgat cccggggaat cccggcggag gcgggcgcgg tcagagattg ttcagccagg
     7861 tgcgcaggtc gtccgggccg ctgccctcgt cgaatccgac cacccggctg cccttctcct
     7921 gaccggcgga gatgtcgatc agcgtcggga tgtactcgat cccgtacttg tcggcgatgt
     7981 ccttgttctg gccctgctcg ctcaggtcca ccttcgccca gatccacttg ccgccgtcgg
     8041 ccgcgtggta tttctccagg tagggggcca tcttctgaca ggggccgcac cagctggcgt
     8101 agaagtccag cacgaccggc ttggtcttgg acatctccat cacctggtcg tagttggccg
     8161 aggtgacgtc gacgacggtc tcgtcctgcg gcgcgagcga agcgtaggac gccggggtct
     8221 gcgcggcgct cgccggcgtc gccgcggcac cgccgaggac tcccgccgtc atcgccgcga
     8281 cggccgcgaa catccggatt ctcgttccca tgtgctctcc tctattcggg gtgggtgacc
     8341 ggcaccggcg ccggacgcgc cggggtttcg ggggcggggc cggtttcggt ggggtgcccg
     8401 gcgccgaccc agtcttcgat tccttcccgg tacttgcgga cgtcggcgta cccgagttcg
     8461 agcagccggg cgccgacgaa ttcgctgttg cggcaagggg tgttggcgca gtagacgacg
     8521 atcgccgcgg ttttgtccgg gacgacccga ggggcgtgct cgtcggtgaa ccgcgcggcc
     8581 tgctcgtagg ggaagcccgg gatgttgcgg gcgccgggaa ggtgttcgcg ggcgtagtag
     8641 tcgggcggca tggtgtcgac gacgatcacc gtgccctcgt ccatcgcggt tttcagctct
     8701 tcgcggccga tcagcggcag catgccggtt cctcccgggt tccggcggcg ggcaagcagg
     8761 cccgccgcga ggtgactgac gaacgccacg accaccgagt tgatcgtggg aatcccgaag
     8821 tcgaagacga ccgcgaaggc cgttccgagc gcccagctga ccagcgcggc gagctcccag
     8881 tcgcgaccgg cgacggcttg cccgcggcgc agggcggcga aaaccggacg gcaccggcga
     8941 agcacgaagt actccgcgat gagcaccccg gcgaccggcg gggcgagcac gccgaccgcg
     9001 gtcaggaatc cggcgaagtc gtcggcgatc ccgagcgccg acgccgccgt gccgaacacg
     9061 ccgagcacca ggaccacgtg cacccggctg accttccggt cgaacagcac gtccacgacg
     9121 ttgaccaggc cgagcgagga ggagtacagg ttccagtcgt tgatcttgag gatcgcggtg
     9181 gccagcacga gggtgccgag cagccccgag gaggaggtga cgatgccgac gacgtccgag
     9241 gtggcggcgg cgtgcgcgag cagcacgccg atcagcccga tcaggtactc gccgagcgtc
     9301 acgctgatca cggtctgctt gaccacgtcg gcgcgggtgc ggttgaaccg cgtcatgtcc
     9361 ggggtcatca gcgcgccgag gatgaaggct ccggacacca gcgtggtcgc cgcgccgagc
     9421 gacagcggcg gtcccggcgg gggagcggcg accaggtccg ccagcgagtg cgtgtgcagc
     9481 gcgtcgagga ccgaataccc cgccagcacc aggaaagcgg gcacggtcag gtaggcggtc
     9541 caggccatca ggcggaagcc gtagacggtg atcacggtga tcgccgctcc gccgaccagc
     9601 gcccagcccc attccggcag cgcaccgccg agggcgtgca tcccgtgcgc gaacaccccg
     9661 ttctgcacgc cgaaccagcc cgcgaggctg atcgccacga gcaggccgac cagtgcggaa
     9721 cccttccggc cgaatccggc ccagcgggcg agcaccgagg tggacagtcc ctcgcgcacc
     9781 ccggcgatgc cgagcagcac ggtgatgacc tccagcagca ccgaaccgat cgtgatggcc
     9841 agcaccgcgt tccagaacgt catgccgtag cccagcagcg cgccgacgat gaactgctgg
     9901 aacgaggaca cctgcccgaa ccgctgcacc gcgaccgacg gccaggaccg gcgggcggcg
     9961 tccgggacgc gggtcagcga atagtcgtcg tgccggtcgt tcatcgcccg gtcgcttcca
    10021 gtgcggcttc ggcgacgacg aggaaaccct gtcccggctc gggccggaag gcgaattccc
    10081 ggtcgaagaa cttctcgaga aacggcaccc gctggtggta gacgaacatc gaccgcggat
    10141 ttccggtgat cagcccggaa ccggcgaaca acgggagttc ggcgaggaag taacgcacgg
    10201 cgagccggag cgcctgctcg tccggcacgt ttccggtccg gccctgcagc acccaggtgg
    10261 aagcgccgta gcaggcggaa cggaatgcgc tgtcggtttc gaagtgggtt tccgccgagg
    10321 ccagcagttc ccgataggac ggcagttcgc gcagccgggc catgccgagg atccggctct
    10381 ccgggtcggg cacgtccagc gcgcgcagcg cggcggcgat cttgttgtgc acgtggcagg
    10441 actgccggtg cgccttctgt ttcgccctgg cgggcgggta tccgagcgct tcgagcgtgt
    10501 aggcggtgac ctcgtccggg acgaaaaagc agaactcggc gaagcggtcc gcggtccacg
    10561 cggcgagccg ggccagccgt tccgcggtga agtagccgtt gaacgggctc actccgacgc
    10621 aggcgtgccg gacgtccgga tacaggcggg cgcagccgga agacagcgga gtcgcgtcga
    10681 acattgaaaa ttccaccttt tctcgtctcg attccgcgtt tctcccggcg gggcgggact
    10741 tggtgcggct cactgtgccg ggatccgggc ggcgcgggta atgcctgccg gttatgccgc
    10801 cgcgggacgg cggcgactgt gcgatgcgga ggttcgcgag aggaacccgc gcggaatcag
    10861 attccttcag ggttcccctc gcggacttcc gcgggagtgc ggccacggcc gcagttcgga
    10921 aagaggattt cctactttgg tcgggcgatt gccacacttt cgccggtgca ctcgcaccgg
    10981 cgggcgtcat atcgtgaact ttcgtggagt tggaactcaa gcatttgcgc cacctccagg
    11041 cgatcgccca agcgggcagc ctcaaccgcg cggccaccga actggtgctg ccgcagcccg
    11101 ccctcagccg cgaactgcgc cggatcgagg aactgctcgg caggccgctg ttcgaacgcg
    11161 cccgcgccgg ggtgcggccc acgccgttcg ggcagctgat cctcgactac gcggacggga
    11221 tcctggcgcg caccgcccgg atcgggcccg ccctcgcgca gcaccgcgcc cagcgcgaca
    11281 gtgcgttgcg ggtcggctgg tcggagaccg tcctctccgg tccgttgctc cgtgcgctgg
    11341 agacgaccgg gctcggcgac cgggcggaga tccggaccgc cgagtcgacc gcggagatgc
    11401 tcgtctggtt cggccgcggc gaactcgacc tcgccgtcct gtccgaacag tgcgaggtgc
    11461 cgctccccgc gaacaccggc cggatcgacc tcgccgagga cccgctgctg atgatgctcc
    11521 cggactggca tccgctcgcc gcccgccgcg aggtggacct cgccgaactg gagcacgagc
    11581 ggtggatctc ctcgaccggg ccggaccgct gccgcgagtt cctcgccagg gtgtgcggcc
    11641 cgtacggctt cgccccggtg atcgcccact acgtgccggt ctccggcccg cgcgacgaga
    11701 tcgtccgcta ccaaggcgac gtcacgctcg tccaggcctc ccgcccgctc gccccgggag
    11761 tggtgcaccg gccggtcccc ggcctgcgcg agcggacccg ccatttcctg ctgtaccgcg
    11821 aggacagtcc ggtcgccgcg cgggccggcc tgctggccgg gctgatcctc gacgcctacc
    11881 acgacgaaag gggcggctac gacggcccgc gcgcgattcc gggggaactg ccgtggctga
    11941 ccgcccggac cagctgatcc gcaccggcac ggacctcgag ctgcggcagc tgaagctgct
    12001 ggtcgcggtc gccgaggcag gcagcgtggc ggctgccgcg gccgcgctgg gcaccactcc
    12061 ggccaagctc acgctgcgga tccggcggct ggaacggatg atcggcgccg cgctgctggc
    12121 cgcggaaccg gcagggaagc tgttcaccga aaccggcgag gtcctgctcg aacacgcctc
    12181 ggcggtggtg ccgcagttcg accggatgct gaccgccgct cgcgccggac tggagcgccc
    12241 cgtcgcgcag atccggatcg gctcggtgcc gacgcccgtg ctgccgcggc tgatccgcga
    12301 ggtggggctg cgcaaccccg gcgccggact cgcggtccgg accggcgaat cggccgcgga
    12361 gctggccgaa gcactgcttc gtgcggaact ggacctcggc ctgctgcgtc aggacgccgt
    12421 ccgggaacgc cccctcgaat gggtttcgat agccacggag ccgctggtgg tcggcattcc
    12481 gcccggacat ccgctcggcg ttccggattc gctcacgccg gccgcgctgt ccggccggcg
    12541 ctgcgtgctg ctcgaccagg ccgtgcagcc tcggacgcac gcactgctcg cggccttcgc
    12601 cgacgctggc gctgatccgc ggctttgcta cgccgacagc gaatgggcgg tgctgtgtgt
    12661 cggttacggg gccgggatcc tgaccgtgac agcgccgccg acgagaccga tgccggacac
    12721 ctcataccgg ccactgcatt gtgcggccac gaattcgact ctcgtgctcg cctgggctga
    12781 ggacagcccg tttgccggtt gcgtcccgcg cgtccgtgcc gcgatgacgc gcgcgcacgc
    12841 cgaatccctc cgcgcactgg tcagttgccg tccgtgaagg actccttgcg ggaatcagat
    12901 tcccgcaagg agtccttcac ggacatcaga gatcagccga tgcggtagct gtagggcaga
    12961 gtcgccagca cctcgccggt tccgacctgc ggcagaccgg tcacgccggt cggcagcgaa
    13021 ggcacggtca cgatgttcag gtgcccggcc accttctgcc cgcggtcgcc cgacggcgtg
    13081 atcgtcacca gaatcgtcgc ggtctcgccc ggcttcacca gctgcggcgt gccgccggtg
    13141 ccgttcgggt ccaccgactg gccgtacggg tcgccggtcg acgacgtcac cgaaccgtcg
    13201 aagcccgccg tctggatcga cgccgtgtag ctcgaatgcc cggcaggcgc gccttccgga
    13261 ccgaacgggc cgatctcctg cacgtcggcg aaccagacgc ccttggtgac gtacccggtc
    13321 ttctcgccga tcgtcgcgac cgacaccgtg ctgccgttct gcgcggactt caggtcgccg
    13381 agcacgtcga tgcccgccgc cgaaccctgg atctccgcct gcgcgggcac ggtcgaggag
    13441 gtcgcgacgg tgaacttgct cgtctcgggc ggaatcgagt agaccggagc gtccgagttc
    13501 agctccggca ggttgacctc ggtcgacccc tggatcggct gcggctgcag cgtttgcctg
    13561 gtgttcgtgc gcgcgtcgac gccgatggcg agcggttcga cgccggtgtt gcgcaccgtc
    13621 accggcacgg tcaccgcctt gcccgcggcg agcgacgcgg actgcggcag cgcgggcgcg
    13681 ccgaccgaga cctggtcgaa gccgacggtt ccggtgaacg gctggtcgat ctgcttgccg
    13741 gtcaccgggt tctgcacgac gagcaccagg tgccagcggc ccggcagcgg gttcgcgtcg
    13801 acgagctgca atccggtgcc ctgcttcagc gtggtggccg aatcgaggga ggcgttgctg
    13861 ttcacgtcgg cgagttcgcc gttcgggtcg accaggacgc cgtcgagcag agtgcccgga
    13921 tcctggagtt tcaccgcgac gtcgaggtcc cgcttgccgc gcggaacgtc gaattcgtag
    13981 gagaaggtct gcgcgggcga caccgcacgg gcgttgccgc cggtgatcgt gccgctgaag
    14041 gcgcccgggc cgttcttcgt cgggatcagt gcgcgcagca cggccgacac ggtggtctgg
    14101 tggccgtcgg agctgccgaa ggtgatcgag tagtccgcgt cgccgccgct ggccggggtc
    14161 tgcagcgcga cgtgcaccgg cttcgtctgc cccgggttga gctgcaggat ctgcggcgag
    14221 acctggccgt acgggacagc ccgctgcgcg gtggtcgcca gctggacgtc accggtgtaa
    14281 ccggcctgcc cggacgccga gtagagcacc gcggtccacg tgcccgcggc cgggcgcgtg
    14341 acgtccacat tggcgtagtt cgccgtcgcg gccccgccct gcggacggct gttggcgacg
    14401 aaagtgccgt ccggcgcgag cagcgtcagc cgcaccaccg gggtgaccga ctggccgttg
    14461 accgacttcg ggctgccctg ccacgccatc cgcgccagca gccgctgcgc gccgttcggc
    14521 acggagaacg tgaccttctt gtacgcccag ttggtgccgt tgaagtacgg gaaggtcggc
    14581 agcttcgtcg agtcgaacgc cgtggtctgc gcctgcgtgc ccatcgggga gaacgtccgc
    14641 gtgccggtgc tgaccgtcag cggcttggta cccgagttgg tgacgttgac cgacgcctgc
    14701 tgcgtgctgc ccggcgcgcc ttccagcgtc agctggtcgg ccgacagcga gatgttcgac
    14761 gaaacgcccg ccggcgcgcc ggtcgagccc ggagcggtga gcgccgcttc gaccgccgcg
    14821 cgcgcgtcga gaaggccggc gccctgctcg tcggccggga ggttgaggtc gcgcgcggtg
    14881 ctggtgatga tctgcttcac ctgcgcgggc gtcggcgacg tgccgtggtg ggaattgcgg
    14941 tagctctgga tcaccagtgc ggcgacgccc gcggtcagcg gggcggattc actggtgccg
    15001 ccgaaggatt cgaggtcggt cggctggggg acggtgttga agttgcggca ttccgagtac
    15061 gccggggagc aatcggccca gttgccctcg ccgggcgcga cgaggtcgat ggtgcggccg
    15121 ttctgcgtga tgcccgacga cgacagagcg gagatgttgt cgctgaccca tttcccgttg
    15181 gagaacggga aagccgcgta gccggtctgc gcgtacagcc ggttgtcggt ggtcgcgccg
    15241 gtggagatca ccagcgggtc ggtggccggg ctgccgatcg tggacgtggt gcccgcgtcg
    15301 ccgctggagg cggtcaccgt gacgcccgcg gccacggcct ggtcgttgaa gacctggaac
    15361 aggttgcggg agctggaatc cgggtactgg ttgaggccga gcgattcgtt gatcacgtcg
    15421 acgtggtcga cggtcaccgc gtagtcgatc gcctgcagca ccgcggagtt cgtggcggtc
    15481 ttgccgaaga cgttcagccc caccaggctc gcgcccggcg cgacgccctt gacgacgatg
    15541 ttgcagcctg ccgggagcgg gtgcttttcg ttcacgaact tcgacaggtc gtgcaccacg
    15601 acgccctgcg cggcgatcga cgaagcgtcg ccgaatgcct cggcgccggc gtcggtcgtg
    15661 ttcgggccgt cgccggagaa gtcctggtag tccgagaaca catggctgcc gtcgggacgg
    15721 atgaagtccg cgtagttcgg gtccatgttg tcggcgagga acgcgacctt cacgccggcg
    15781 ccattggcca gatcggacgc gctcttgccg ccggtggtgc tgtacgcgcg gatcgacgtc
    15841 agcgcttcgg gctccagcaa cggtttcgcc ggatcggccg ggcaggtcgc gttcggcgaa
    15901 gccggtgcgg aaggtccgcc tgccttcggc gcggcggccg gtgcgcccgg tttggcgtcc
    15961 ggcagcgtca ccttgctgtc cggcagcacc tgcgcgaccg ccgggtcgtg cgcgagctgc
    16021 gcggcctgcg cgggcgtgac ggtggcggaa aacgcgttgc ccagcgcgaa gtgcttgact
    16081 ttggccggtg ccgcgccggc gagcttggcg agcaccgagt cctgttcttg ggtcgctttg
    16141 gcgcggcgag tgtccgaggc cgccttggtg ggcggcgcgc tgggcaactg gtccgcgagg
    16201 acgacgatca ccgattgcgg cgcggtgtcc gccgcggcgg ccggtgcggc agcctgcgcc
    16261 ggctgggtcg ccccggccag caccaggctg ccggtcgcag ccatgaccag ggcgcgaacg
    16321 gatcgcgagg aacgccccat gtgcagttcc cacttcctgc tagaagggtt cgtgagttac
    16381 cggccccgac gaaatcgggc gcactcgtgc cgcgctcgat ttcccagtag cagaactctt
    16441 tccgactccc gcacgatcca caagcgacaa tagtgggaaa caaatccggc aaacgggacc
    16501 gaatttccgc gcggtcgcgc attcggtccc gtttgccgga atcggggtca gtcctggggg
    16561 aggtgtcggc gcgagtgtcg cgtcaccaca agggttcccg cgatggcgac cagtgcgacg
    16621 caggcgagca gcaccgggta gcccgctact gcgttcagtg ccgccagaag tgacggcaag
    16681 aggaatccga catacgccag cgcgtagtac acgccggtga gttccgcgat ttcgtccggc
    16741 cgggcgagac gttgcaattc cagcagtccg gacaccacga cgatgccgta agcggcgccc
    16801 agcacgaccg ccgcgccgag cgcgatccac ggcgattcct ccgctgccgc gaagacgctc
    16861 aggacgagtc cggcgcagag caccgccatc ccggtgagca cggcgcgggc gctggtggcg
    16921 cggtcgaccc gcttggcgat cggctgaatc cccacgcccg cgccgatcgc gcagacggtg
    16981 agcaaggtgg agtaggccag cgcccacgac ccggtctggt gctcgacgag ctgcggcagg
    17041 atcgcgtacg ccacgccgca cgagccgaag atccacggcg cggcgggcag gatcacccgg
    17101 cggaaccgcg gatgccgcgc ggtggcgggc aatgcggcgc ggaccgagcc ggtccggaca
    17161 gcgagcgttt ccggactgcg cgtgaccgcg agcagcgaga ccagcgcgag tccgatgtgg
    17221 accaggtagg ggaggaccat cggccacgga ccccattgcg cgagcgctcc ggcgacgccc
    17281 ggcccgatgc cgagcccgag tgtcaggcac agtgccgcgc ggcgggtgcc cgtgtcggcc
    17341 gcgctgtacg ggtcggcgtc ggcgagctcc ttgatccagg tggagccgac ggccatcgcg
    17401 accgcgaccg cgatcccgga gaggaaccgg cccgcggcga tccacccggc gccggccggg
    17461 ccgagcgcca gcagcacgct cgccagcagc gacaacacgg tgccggcgaa catcaccggg
    17521 cggcgaccgt accgattgga cagtccgccg gacagcagca gccccggcac gaggccgacg
    17581 acgtacgcgc cgagcagggc gtcgacggtg aacgcggagt agcccgcggc gtggtacatc
    17641 acgagcagcg gggtgaactg gttgccgccc catccggccg cgaacaccgc cgcggcggcc
    17701 ggaaaccagg ccgggcgagt ggtcgtttcg ggtgtgtcgg gcagggggtc agcagtagtg
    17761 gtcatcgacg gtgcaccgaa tccaagtgtg cgcgcagggc cggggcgaag gtgtcggcct
    17821 tcgtcccggc ctccgcgatg atgttcagga ggtcttcgtg ctcgccgacg acccgcggca
    17881 ggcgtgccgg gatcggcgcg agcgcgtgga cgttcatccg gcgctgccgg tcggcgagcg
    17941 tcgtgtagaa ggcgagcagc aatgcgttgc cgcccgcctc gacgatcgtg cggtggaaca
    18001 gggcgtcggc ttccgcgaac gcgggcacgt cgcccgcgtc cgcgtgctgc cgctggacgt
    18061 ccagcaccgc acgcagttgc tcgagcgccg ccgggatcag ctccggacga cggcccagcc
    18121 gttgtactgc cgcgctttcg accgcctcgc gggcttcgag cacgtcctcg gcctcgcccg
    18181 gggtgatcgg cacgacgatc gcgccgcgct tcgggatcag gttgagcagc ccctcgacct
    18241 gcagccgcag gaacgcctcg cggaccggcg tccggctcac cccgagccgc tcggcgatct
    18301 cgccctcgct gaacaggtgg ccgccgggca gttcgccggt gagcacgagt tccttcgtga
    18361 gctcgtacgc gcggtcggcg gcgggtttcg acgcgttcac aggtgtgacg ctaacatgca
    18421 tcccagcttg tatctaagcc gttgtgacct gcggctcagc tggtttgtcg ggggcgtgtg
    18481 cgatgctcct cgggtgctgc tgctcgacgc ccgaccgacc gtgaaccaag ccgtcgacgc
    18541 catccgcgcc gccttgaccg gcggcctgga cccggaccag gacccgccgc ggtccgtcgt
    18601 acccgtgccc accgggcagt ttctgctgat gcccgcgttc tgggaccgct atgccggggt
    18661 caaggtcgct tccgtcgccc cggacaaccc ggcgcgaggc ctgccgcgga tccaaggcca
    18721 ctacctgctg atggacggcc cgacgctcac ccccatggcc ctcctcgacg gcgtcgcgct
    18781 cacgtcggtg cgcacggcgg ctgtttccgc ggtggccgtg gacctgctgg cagtgccgga
    18841 cgcggaacgc ctggtggtgt tcgggaccgg tccgcaagcg caaagccaca tcgaagcttt
    18901 ccgtgccgtg cgaccggtgc gggacgtagt ggtcgtcggc cgcaatgcgg agcgtgcgca
    18961 agctttcgcc gcgcagtacc cgttcgcccg cgcgggcact cccgacgacg tgtccgcagc
    19021 tgatctgatc gcctgctgca cctcgtcgcg cacccccgtg ttcgacggag cgaaggtccc
    19081 cgagcacgcc accgtggtag ccgtcggctc gcacgaaccc gacgctcgcg aggtcgacga
    19141 tgtcctcatc ggacgatcca cagtggtcgt cgaaggcatc ggcgcggcta cccgcgaggc
    19201 cggggatgtc gtaatggcaa tggaatccgg cgcccttgcc gcggacgacc ttgtctcgct
    19261 cgccgcgctg gcccagggtg ctgcggtgcc gccgggtcct cggctgttca agagcgtcgg
    19321 aatggcttgg gaggatctgg cggtcgcggc ggccgtctac gaagcggtca agtgacatcc
    19381 cggcgaagcg ggaacgcgac cgccagtccg gccgcgacca gtgcgtagcc gaggagaacg
    19441 agcgcgccgc ccgcggtggg cagcagctgt ccgcccgcgt ggccggtctg ctgggccagc
    19501 gcgtcggcga ggtaaccgaa ttcggtgagc gccgcggtgg ctccgccggg aaggaaggga
    19561 tagatcgcgt tcacgcccgg aatggcgagc agcgcgatct ccaccaggta cagatatccg
    19621 atcacgaccg ccagcgcggc gacttggttc cgcagcagcg caccgattcc cacgctcagc
    19681 acggtgtaga tcgtcatcgc ggcggcgatc cggagcagaa gttcgaggac tgttcccggc
    19741 gcgaggccga cagtcactcc gtggacggcg gcgcttccgt agagcgcgag cccggcggcg
    19801 gccgcagtga cgacgccgta gcagagcccg ccgatggcga acgccgcgag tttcgcgacg
    19861 aggatccgcc agcggcgcgg tgcgaagagg aacgtgacgg aaatcgtgcg gtgccggtat
    19921 tccgacgtca tcgcgacagt gccgaagacg gccgggaaca ggactgtcac ggtcgccatg
    19981 ccgaggacat tccgcacccc ggcggcggtg tcgagacccg gcatcggcgg ctggacgtgc
    20041 tgcgggccga tcacgccgat cagcccgacc agtccgccgc cgcacgccgc ggccgtgacg
    20101 agcgcccaca gccacagccg ggtggagcac aaccggcgga gttccgcggc gatcatcgcc
    20161 gctcgcccgc ggtgagggcg aggaaaacct gttccaggcc gggtttttcc ggggtcagct
    20221 cgtgaatccg gagtcccgcc gcggccgccc ggtccgcgat ctcggcggtg ccgatcccgc
    20281 ggacccgaag gagatccggc gcgatccgct cggcagttcc gcccagcgcc cgagcgagtt
    20341 cgtcggcgtc aggggaacgg acaagcgcga cggacgcggt cgaggcggac aggtccgcta
    20401 cggtcccggt ggcgacgagg cgaccgtcgc ggatgaccac gacctgcccg gcgatctgct
    20461 ccagttcgct gagcacatga ctggaaacca gcaccgtgcg cccgcccgcg gcgaacccgg
    20521 tgagcaggtc gcgcaaccac gccatgcccc gcgggtccag cccgttgccc ggttcgtcga
    20581 gcaccagcac cggcggatcg ccgagcaacg ctgtcgcgag actgagccgc cgccgcatgc
    20641 cagtggaata gccgcgcgag ggccgccccg cgaagccggt catc
//
