LOCUS       NZ_AP025344            11230 bp    DNA     circular CON 24-MAR-2024
DEFINITION  Paenibacillus dendritiformis strain J27TS7 chromosome, complete
            genome.
ACCESSION   NZ_AP025344
VERSION     NZ_AP025344.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus dendritiformis
  ORGANISM  Paenibacillus dendritiformis
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1
  AUTHORS   Okumura,K., Okamoto,M. and Takamatsu,D.
  TITLE     Whole-Genome Sequences of Bacillus and Paenibacillus sp. Strains
            Isolated from Honey in Japan
  JOURNAL   Microbiol Resour Announc 11 (11), e0084222 (2022)
   PUBMED   36301092
  REMARK    DOI:10.1128/mra.00842-22
REFERENCE   2  (bases 1 to 6547390)
  AUTHORS   Takamatsu,D., Mada,T., Okumura,K. and Okamoto,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2021) Contact:Daisuke Takamatsu National Institute
            of Animal Health,NARO; Kannondai3-1-5, Tsukuba, Ibaraki 305-0856,
            Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3
            Genome Coverage                   :: 124x
            Sequencing Technology             :: PacBio; NovaSeq 6000
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_021654795.1-RS_2024_03_24
            Annotation Date                   :: 03/24/2024 09:12:59
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,875
            CDSs (total)                      :: 5,765
            Genes (coding)                    :: 5,679
            CDSs (with protein)               :: 5,679
            Genes (RNA)                       :: 110
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 82
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 86
            CDSs (without protein)            :: 86
            Pseudo Genes (ambiguous residues) :: 0 of 86
            Pseudo Genes (frameshifted)       :: 39 of 86
            Pseudo Genes (incomplete)         :: 62 of 86
            Pseudo Genes (internal stop)      :: 15 of 86
            Pseudo Genes (multiple problems)  :: 26 of 86
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:45:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4538710
            Orig. end                         :: 4549940
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP025344.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotated by DFAST https://dfast.ddbj.nig.ac.jp/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11230
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="14"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11230
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11230
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6230](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6230)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(945..958)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.07"
                     /tool="antismash"
     gene            complement(2432..3223)
                     /db_xref="GeneID:73386562"
                     /locus_tag="L6439_RS20130"
     CDS             complement(2432..3223)
                     /codon_start=1
                     /db_xref="GeneID:73386562"
                     /inference="COORDINATES: protein motif:HMM:NF017946.4"
                     /locus_tag="L6439_RS20130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC-2 family transporter protein"
                     /protein_id="WP_213469589.1"
                     /transl_table=11
                     /translation="MNPTRYIALLKLLGKQSLAQMLTYRMTSTFIIIFGTLFAFADIIG
                     TVVFFQYTESIAGWEIYDFLVLLSTFQFISYLYQFFFVASHENLMENILNGKLDYDLLR
                     PVDSLFLCSMKQLDFPSVINMIIPSFIFFYCLPYIKIELNLLNVFIYILFVALGVIFYY
                     LLNQMFICLAFWVDRPQKIAGVPEYMLDFASRPREVYPRILQIILSTVFPVITAVNLPA
                     EYLKGSLSINYFVFYLFFLILFGIVVRFQWKCGISRYASAN"
     gene            complement(3220..3999)
                     /db_xref="GeneID:73386563"
                     /locus_tag="L6439_RS20135"
                     /old_locus_tag="PsJ27TS7_40980"
     CDS             complement(3220..3999)
                     /codon_start=1
                     /db_xref="GeneID:73386563"
                     /inference="COORDINATES: protein motif:HMM:NF017946.4"
                     /locus_tag="L6439_RS20135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PsJ27TS7_40980"
                     /product="ABC-2 family transporter protein"
                     /protein_id="WP_213469590.1"
                     /transl_table=11
                     /translation="MKTFWIIVKNNMLITLAYRWNIMSSIVLMIIQMIVGLFVWIVIID
                     QSGPINGYYHDDMVTYFLLGAFISVVFSSSHFFRLSSLVRNGVFNMYLIRPYSFLADSA
                     AQFLGSKIIDALLTLMLTLIFLATGLATWPSLNILGLFLFLSNFLLLFMFGAFLSCFSF
                     WLIQMWPLKPLYNAMMAILGGNLYPLDLLPAIWFRVIHFTPFPLFGYVNTKLLQGKLEY
                     HDLQYYVLLSCCWLVVFSIGYKWLFMKGLRKYEGVNA"
     gene            complement(3968..4975)
                     /db_xref="GeneID:73386564"
                     /locus_tag="L6439_RS20140"
                     /old_locus_tag="PsJ27TS7_40990"
     CDS             complement(3968..4975)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:73386564"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="L6439_RS20140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PsJ27TS7_40990"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_213469591.1"
                     /transl_table=11
                     /translation="MEINIQNLNHDYITYRKRQGLKGAFQDFIFRKYEHKTVIKSVDLS
                     IQAGELIGLLGPNGAGKTTLMKIMSGLIHPTSGTVEVMGHVPFKKNPDFLRQLGVVLGQ
                     KSQLTWDLPPIDTLQVLKEIYKVDDVTFQKRLYELVHKLNVEHCIQVPVRKLSLGERMK
                     FEIIASLLHSPKLLLLDEPTIGLDMASQKSIRSFIKEINREYGTTVILTSHYAKDIEEI
                     AERLIILNKGSIHYDGLLGHLQEENHHEMTLKIEIKQYESLADLGFKKTGDRQWETHLA
                     SENLNTLLSKLTQLYTVTNIQTYDIPFEEKLYTLFTRLLSDGEANENLLDNSKK"
     gene            complement(5001..6230)
                     /db_xref="GeneID:73386565"
                     /locus_tag="L6439_RS20145"
                     /old_locus_tag="PsJ27TS7_41000"
     CDS             complement(5001..6230)
                     /codon_start=1
                     /db_xref="GeneID:73386565"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR00702.1"
                     /locus_tag="L6439_RS20145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PsJ27TS7_41000"
                     /product="YcaO-like family protein"
                     /protein_id="WP_213469592.1"
                     /sec_met_domain="YcaO (E-value: 3.8e-44, bitscore: 150.2,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNIERSTSVDYAIQAALKEIRELGLDFSIKDIGRYIKTHICILY
                     KNGDELTRGNGKGIDNQSKASALYEALEHFISENEVLDGSKKMKIQHVVEQSQAIRDEK
                     VFELLMKSYPDYRVPVKEYFDLREEGNVIYYPSFLTNPSHCIDQPPDDLFYKNYSKYSS
                     NNGTAIGCCKEEALVHSICELIERDAFSCFLLESFISRNPKPMKIVDKKRLPEKLEYLI
                     DNVHSELERDFYILDITSDFQIPVFLCVMENKNLLPPYIGCGASLSPYYALERALLELV
                     QVYHLYNEYYEVLKKEDELILKKFSTLKKYKNCVDFDISGGLFEKNNNIMININEEKIN
                     NDSLEDYLNILINKVTNNGFEIYANVLYSSKSDITCVNCIIPGLERFHLVRHGSLVLPS
                     LRGRNILVNA"
     misc_feature    6490..6506
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 22.69"
                     /tool="antismash"
     gene            complement(6696..7916)
                     /db_xref="GeneID:73386566"
                     /locus_tag="L6439_RS20150"
                     /old_locus_tag="PsJ27TS7_41010"
     CDS             complement(6696..7916)
                     /codon_start=1
                     /db_xref="GeneID:73386566"
                     /inference="COORDINATES: protein motif:HMM:NF025007.4"
                     /locus_tag="L6439_RS20150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PsJ27TS7_41010"
                     /product="cupin-like domain-containing protein"
                     /protein_id="WP_213469593.1"
                     /transl_table=11
                     /translation="MSEYFEKKPGVFKSENNNMLVTEKELFESILNGIEMWRKGSERTF
                     SIWLDNELVTNNFEKYIPNKNDKCISCYINRIVGSPKSKDFTYSQYNLQCNHLDIWRKG
                     AKYLEGLLNIIGIPSGGIDIDTFLGNYKSTPRGVHTDQASTFMHIIKGKKKMLVWPPEY
                     FQELENTSQIKIVGSRLRKTIIDFDFSRVASDAILLEGEPGEILYWPSSYWHISVFDSD
                     NHPSVICNVGIYREEFSSFLSEIGIQCIKTATKNYIDLKTYSYPDKHSEYQIPKEEQDY
                     LNKLRLLINNTYIEEYIQQKWIERMSACGYKSGFPLLQVREINGKEFIRDSVIYWSIHK
                     TKSTIRIYGNGNSIEHSDLTIIPVLRYINKLRNVEIETLYSIFRIQQESIIQIIKILLS
                     LRILRSV"
     gene            complement(8535..8678)
                     /db_xref="GeneID:73386567"
                     /locus_tag="L6439_RS20155"
                     /old_locus_tag="PsJ27TS7_41020"
     CDS             complement(8535..8678)
                     /codon_start=1
                     /db_xref="GeneID:73386567"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="L6439_RS20155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PsJ27TS7_41020"
                     /product="hypothetical protein"
                     /protein_id="WP_213469594.1"
                     /transl_table=11
                     /translation="MGNARTEKNGHDPFEFKLANNTELEELLLHLSSNKDELNEVKALN
                     KD"
     misc_feature    complement(9050..9065)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.04"
                     /tool="antismash"
     gene            complement(9229..9600)
                     /db_xref="GeneID:73386568"
                     /locus_tag="L6439_RS20160"
                     /old_locus_tag="PsJ27TS7_41030"
     CDS             complement(9229..9600)
                     /codon_start=1
                     /db_xref="GeneID:73386568"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006675008.1"
                     /locus_tag="L6439_RS20160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PsJ27TS7_41030"
                     /product="hypothetical protein"
                     /protein_id="WP_213469595.1"
                     /transl_table=11
                     /translation="MSSRGTQVWGSAALHTEPIVIKGTNNTFIFQVDGTEYEASIPQGT
                     YATRLELFTSELIEPVNEALRQAQAPVIARLGGNRQDKHICVLVLEHTDTSDDHVIDGF
                     GGSARDVIWGESEHISAVQ"
     gene            complement(9605..10114)
                     /db_xref="GeneID:73386569"
                     /locus_tag="L6439_RS20165"
                     /old_locus_tag="PsJ27TS7_41040"
     CDS             complement(9605..10114)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:73386569"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019004155.1"
                     /locus_tag="L6439_RS20165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PsJ27TS7_41040"
                     /product="phage holin family protein"
                     /protein_id="WP_237096560.1"
                     /transl_table=11
                     /translation="MYDKIVNSSIGFIGGLMSYLYGGGSSLLEFLALLALMDYISGYAA
                     SVMEAARGMPQAGLSSKKGFAGLAKKGLMFVVVLLAHRADVALESDFLMYGAIWFYISN
                     EVISIAENSGRIGLPLPPQIKQIIAILKTREQQQRQQEQDNEKNEQNNDQRQHEQGNGP
                     TIRKEG"
ORIGIN
        1 tgacgaacga cttacccggg aaggccggat cgtcgcggaa ctcgacccag gcggcgccgc
       61 ggaaggaggt gccgtagcgc atcgaggtca tccgcgcttc gaacgtagtc agatcgatct
      121 cggtgatgac tccgttggcg ggaacataca ctttgccgtc cttcgtcacg agctggttga
      181 aggagaatac gccagcgccc tgcgtaccgc cgatgttttt gccgacgaca tgcggcagcc
      241 actctccccg atcgagatca tagaacagca aggccatctg cggatcgccg aacttcacca
      301 gcaaataacg atcgacgatc gccatatcgt aggcgaacgg cacatctgcc ggattcacgc
      361 caagcagccc cgcgaccggt ccggaaatga cctccttctc gccgctctcc gcattgagct
      421 tgacgatcgc gcccgtggat ccgatccccg cgtaaatata gccgttgtga taggccatcg
      481 accgcacata ttcctgattg cccatcatgc ggccataatc gcgataagtt ttcgctaccg
      541 gatcgtactt gaatactttg ccttgctgga aggtgccgcc atacacattg cccttctcgt
      601 cggtgacgag cgaccagatc gatttctcgc ccggtagcgg ctcgcccagg ctgctcaccg
      661 tcttcgtccg cggggagtag ctccacaact ctccccggtt gctgcccgtc attatcgccg
      721 cgatatagac ggttccatcc ggggcgatcg tatggcgcca caccgtatga accccatcca
      781 acgggaacga ccggagcagc ttgttgctct cgatatccac gacgctgaac acggccgtat
      841 cgccctgcgc ggtcgagtac atcgtggccc gcccgtcctc tacgccggcg acggcatcgt
      901 tgatcgcgac cgtgaagacg ggaatgccca gatcaaccgg ctgagcaaag gttctgccct
      961 tgaagctgat atctccggcc ggcggctcgc ccggcgatgt cttcggatag gtcacctcga
     1021 agtcatcgta atagacttcc gccatctggt acttgttgac cgaggcgaaa atgcgggccg
     1081 tcgccgcacc cgcaggcgct gtgcccgaca cttgcacctt ctgccattcg ccgtagcctg
     1141 ttgacacatg ctgaagcata tcgtcgccga cctgtttgcc gttggcatca taatagcgga
     1201 acagcagact ggcgctgccg ctcttcagca gcatcatgac cgagccggta taggtcgcgc
     1261 ccggttcgac agccagcgga tcgctctgga ccgcgacggc atgatcgcgg ctcgtatcgg
     1321 taatcttcaa gctgcgcttg ccgcggtacg cttcttccct gctgatctca tggctgaccg
     1381 cgccttccac gctggcgaat atcgatgtcc agcccggaat cgagtccttc gctgtctgct
     1441 gctcgaagcc gggatttttc agaggcagcg ccttcgcctc ggagcgggtc tctcccttgc
     1501 ctttattgcc ggttgcggct gtggtcgctg tcgcttgatt attaacagct cccactgctt
     1561 cagccccgac ggcatcgccg catgtcaaca cagccatcag tacggccagc acggcgctaa
     1621 ttcggctgaa ccgcttgctt ctccacggta ccatcattat tcccctcctt catgtcttga
     1681 cttgctgccg cgaccgcatt tgcgctttgt tgtaagcgtt atcaagaatg cggtcggctt
     1741 taactcggga tacctactac tttccggtaa catgtaacct ggcaatgagc cgccattgac
     1801 tcacgcgctc tcctaaacta taacctctcc cgttggaacg gccctgacct tacctttacc
     1861 ttctccgcat ttgtcttcct tgccatcacc cgctagcttc gactctcagc ggccggatca
     1921 cctccttttc atcgattcag gttcttatgt agtgcatata ctcccgcata aaaacagatg
     1981 agcaacaaat gaaatggagt attagattac aactggttca tgtcttctat attacttcgg
     2041 ttgatggcga tgtcaattcg ccggcgattt atagacagat taaagacagc gtgaaggaat
     2101 cggggcagtc ttaatccccg attgaatgtt cgggctggaa aaaaaagtat acgaggaatt
     2161 cggcaaaaat atccagtgag gaatttgggt attaactcat atgtccaccc aaaatcggct
     2221 tcaaatggag gaaaatacag ggaaacgatc tcagaatcct tgttccggac agggctgaaa
     2281 ccaaaccctg ccgtaagctt tacggctttt cttgaaaatt taaagaattg gacgaaatca
     2341 cctcctccaa cccggcactc cttgagctta tgtttatttg tgtaaccgat ccatattgag
     2401 gggagcatgc aaaatgtatc ggtggctaat gctaattcgc acttgcatat ctagaaattc
     2461 cacacttcca ctgaaaacga acaacaatcc cgaataagat gagaaaaaat agataaaaca
     2521 cgaaatagtt aatagataag cttcccttaa gatactcagc aggcaaattt acagccgtga
     2581 taaccgggaa tactgttgat aaaattattt gaagaattct tggatacacc tctcttggac
     2641 gtgaggcgaa atccagcata tactcaggca ctcctgctat cttttgcggc ctatcaaccc
     2701 aaaatgcaag acagataaac atctggttca gtaaataata gaaaataacc ccaagtgcga
     2761 caaacaatat gtaaatgaac acatttaaca agttcaactc gatttttata taaggaaggc
     2821 agtagaaaaa tatgaaagaa gggataatca tattgattac actcggaaaa tccaattgtt
     2881 tcatactaca taaaaacagt gaatcaacag ggcgcaataa atcgtaatca agtttcccat
     2941 ttaaaatatt ctccattaag ttctcatgag aagcaacaaa aaagaactga tacaggtaac
     3001 taataaattg aaatgtcgat aatagaacca ggaaatcata gatttcccac cctgcaattg
     3061 attctgtata ctgaaaaaaa acaaccgttc ctattatatc ggcaaatgcg aataacgtac
     3121 caaatatgat aataaatgtg gaagtcattc tataagtaag catttgagca aggctttgct
     3181 tgccaaggag cttaagaagc gctatatacc tggttgggtt catgcgttta ctccttcata
     3241 tttacgtaat cctttcatga ataaccattt atatccaatc gagaacacaa ctagccaaca
     3301 gcatgataac agtacatagt actgtaaatc atgatactct aactttcctt gcagcaattt
     3361 tgtattaaca tatccaaaca aagggaaggg agtaaaatga attacccgaa accatatagc
     3421 aggcagtaaa tcgagaggat acaaatttcc tcccagtata gccatcattg cgttatagag
     3481 tggtttcaac ggccacatct gaatgagcca aaagctaaaa cagcttaaaa aagcaccgaa
     3541 cataaacagt agcaaaaagt tgcttaaaaa caaaaataaa ccgagtatgt tcagagaggg
     3601 ccaagtcgct aatcctgtcg cgagaaaaat gagggtcagc attaaagtga gtagagcatc
     3661 aataatttta ctccctaaaa attgagccgc actgtcggct agaaaagagt aaggccgaat
     3721 gagatacata ttaaatactc catttcttac taaagaagac agtcgaaaaa aatgagaaga
     3781 agaaaaaacg acacttatga acgcgccgag caaaaaataa gtcaccatat catcatgata
     3841 atatccattg attgggcctg attgatctat aattactatc cagacaaata aacctactat
     3901 catttgaatg atcatcagta caatactaga catgatgttc catcgataag cgagcgttat
     3961 caacatatta ttttttacta ttatccaaaa ggttttcatt cgcttctcca tctgatagta
     4021 atcttgtaaa tagcgtatac agcttctctt caaaaggaat atcgtatgtc tggatattag
     4081 ttacagtata taactgtgta agttttgata acagtgtatt caaattttca gatgcaaggt
     4141 gagtctccca ttgtctatcg cccgtttttt taaaacccaa atcagctaac gattcatatt
     4201 gtttaatttc tatttttagt gtcatttcgt gatgattttc ttcttgaaga tggccaagta
     4261 ggccatcata atgaatcgag cctttattga gaatgatcaa cctttctgca atttcttcaa
     4321 tatcttttgc ataatggctt gtcagaataa ctgtcgttcc atattcacga ttaatttcct
     4381 taataaacga acggattgat ttttgacttg ccatatctaa acctattgta ggttcgtcca
     4441 gaagtaggag ctttggggaa tggagaaggg aagctatgat ttcaaacttc atccgttccc
     4501 caagcgataa ttttcgtaca ggaacttgaa tacaatgttc aacattaagt ttatgcacta
     4561 attcataaag ccgcttttga aatgtcacat catcgacttt gtagatttct tttagtactt
     4621 gtaacgtatc aatcggtggt aaatcccatg ttaactgact tttctgacct agtacgactc
     4681 ctaattgccg tagaaaatcc gggttttttt taaatggaac atgtcccatc acttcaacgg
     4741 ttccacttgt cggatgaatc agaccggaca taattttcat caaggttgtt ttacccgccc
     4801 catttggccc aagtaaccca atcaattcac cagcttgaat ggacagatcg accgacttaa
     4861 ttactgtttt gtgttcgtat tttctaaaaa taaaatcttg aaaggcccct ttgagtcctt
     4921 gccgttttcg gtaagtaatg taatcatgat tcaagttttg gatatttatc tccataatgt
     4981 atctactcca aatggcttta ttaagcgttt actaaaatgt tgcgtcctcg taatgagggt
     5041 aaaacaagtg agccatgcct aaccaaatga aatctttcaa gccctggtat aatacaattg
     5101 acacaagtta tatcactctt ggaagagtat agtacattag catatatttc aaaaccatta
     5161 ttagtaactt tattaatgag aatattaaga taatcttcta agctgtcatt atttattttt
     5221 tcttcattta tattaatcat aatattatta tttttctcga atagaccacc actaatatcg
     5281 aaatctacgc agtttttata ttttttcaat gttgaaaatt ttttcaatat taattcatct
     5341 tcttttttta acacttcata gtattcgtta tatagatgat acacctgtac cagttcaagc
     5401 aatgctcttt caagtgcata atatggagat aacgaagctc cacatccaat ataaggtggc
     5461 aggaggtttt tgttttccat aacacataaa aaaaccggta tttgaaagtc actggtaata
     5521 tccaatatat aaaaatctcg ctctagctca ctatgtacgt tatcaatcaa gtattctaac
     5581 ttttcaggca atcttttttt gtcaacaatt ttcataggtt ttgggtttct tgatataaat
     5641 gactctaaga gaaagcatga aaaagcatca cgttctatca attcacaaat tgaatgaaca
     5701 agtgcctctt ctttacagca acctattgcg gttccgttat tagaagaata tttagagtag
     5761 tttttataaa aaagatcatc tggaggttga tcgatacaat gtgaaggatt agtgagaaag
     5821 cttgggtaat atattacatt gccttcctcc ctaagatcga agtactcctt taccggtaca
     5881 cgataatccg gataactttt cattaaaagc tcaaatacct tttcgtccct tattgcttga
     5941 gattgttcaa ctacatgctg aattttcatt tttttactac cgtctaacac ttcattctct
     6001 gaaatgaaat gttctaaagc ttcataaagt gcactggctt tcgattgatt atcaataccc
     6061 tttccatttc ctctggtcag ttcatcgcca tttttgtata aaatgcaaat atgggttttg
     6121 atatatcttc caatatcttt aatagagaaa tctaatccta actctctaat ttcttttaaa
     6181 gctgcttgaa ttgcataatc aacggaagtg cttcgctcaa tatttgtcat aaaaatccac
     6241 ctcatattgt atttcttgtg gacctaacat gagcccctgt ttttggcaat cgaaaagtcc
     6301 cgaattttgc agccaagaaa ttttatcaat atacagcaac aagtaaggtt tatgcatagg
     6361 tttgacatgg agcctctatg ggcatgattc actgcgaagg ggcgaagcca taggcttcgc
     6421 agaggccaat aagcctatca tgcccatctc tccatatata aaaccagtag ctttttctac
     6481 ataaactatt gctgcaaaac taagcattct tactcaacaa acaagcccct gcatattctt
     6541 ttggaaaata gaaatatccc ctataagttt cgcaagttag atagtggaaa aaatgtatgg
     6601 ataaagggga gggtctagtc tacgtggtta ttccaactat taaggtgtct ttaaggagga
     6661 tcctttttat cacttgatta actctcgaga cttactcaaa cacttctaag aattcttaat
     6721 gaaagcaata tttttataat ctgaataata ctttcttgtt gtattctgaa aatactatag
     6781 agtgtttcga tctcaacatt tcttaactta ttaatatatc tgagcactgg tattatagtt
     6841 aaatcagaat gttctattga gttgccgttt ccataaatcc ttattgtaga ctttgtttta
     6901 tgtatgctcc aataaatgac tgagtctcta atgaactctt taccattaat ctcacgaact
     6961 tgtagtaagg gaaaccctga tttataccca caagctgaca ttctttcaat ccatttttgt
     7021 tggatatatt cttctatgta tgtattgtta attaaaagtc ttaatttatt tagataatct
     7081 tgctcctctt ttggaatttg atattctgaa tgtttatctg ggtaagaata cgtttttaag
     7141 tcaatataat ttttggttgc tgttttaata cactggatcc cgatttctga taaaaagctg
     7201 gaaaactctt ctcgatatat acctacattg caaatcactg aaggatgatt atcgctatca
     7261 aaaactgaaa tatgccaata tgatgatggc cagtagagaa tttctccagg ttcaccttct
     7321 aataaaattg catctgaagc aaccctagaa aaatcaaaat caattattgt ttttcgtaac
     7381 cgggatccaa ctatttttat ttgagacgta ttttctaatt cttgaaaata ttctggaggc
     7441 catactaaca tcttcttttt tcccttgatg atatgcataa atgtgcttgc ttgatccgta
     7501 tgcacccctc gtggggttga tttataattt cctaaaaatg tgtcaatgtc aatgccacca
     7561 cttggtatcc caatgatatt taaaagtcct tcaaggtatt tagcgccttt ccgccaaata
     7621 tccaaatgat tgcattgtag gttatattgg gagtatgtga agtctttact cttgggcgaa
     7681 ccaacaattc tgtttatata acaacttatg catttgtcat tcttgtttgg tatatacttt
     7741 tcaaaattgt tagtaaccaa ttcattgtct aaccaaatac taaacgttct ctcacttcct
     7801 ttcctccaca tttcaatacc atttaaaatt gattcgaata gctctttttc agttaccagc
     7861 atgttattat tttcgctttt aaatacacct ggtttttttt cgaaatattc actcacaaac
     7921 actttccaac caggaaaagg tatagaggcg acagggatac acaataattc tcacctcgca
     7981 aattatggca agttaaaatc ataatcctct agtatattcg aaatattata ataactattc
     8041 taaatactgc acctcgataa agcagaatta catatgtctt attcgtaggt caacgattgg
     8101 gttgaaagtg tactttcatt cattatcttg ttggcggtaa gcttttaaac ctgaaggtac
     8161 ctttgataaa gggataatag aatcgattgt atagggagtt agatagctat atctaactcc
     8221 ctattttaat aaccttgtgc cccatcagac tactataacc cgtttttgaa ggcgtagaat
     8281 ctcctccgat ttggcatttt tgtttctcca acgaaggtag cgttgaatcg gaacagcaag
     8341 ttcgtcatga ttttggtaat tcgaacctga gagaacaaac gaaccaacgg ggaaaaaagg
     8401 cattcaatcc gattgagcca tgaagaatag gttctagcga cgtcggagga ctttgaggaa
     8461 ggccggaaat cacggcttgt ctttggttgc aggtgttgat cttcttggtc gggggcacta
     8521 gctcataagt gtacttaatc cttattgagt gcttttactt catttaattc atctttattt
     8581 gaggatagat gaagtaataa ttcttccaat tcggtgttgt tagcaagttt gaattcaaat
     8641 ggatcatgtc cgtttttttc ggtacgtgca ttccccatat tttatcacct ccttcctgaa
     8701 attataatac aatagtaaat attaaaagta aaggaataac tttgaattta tatgttttaa
     8761 attttttata aatattcttt atcatccgtg ttatataggt agaaaagaat aagcggacag
     8821 tataccccag acaattgaat ccttattttg tccgcccagc tattgacgag tttcggtttt
     8881 tgcttttatc cttgtcagtt ccagtttccg caaatactga tttcgcatga gtgtgacgat
     8941 atgcttatac ggttctaccc gaatggtgtc cagagagtct agagagagtc gaaagcaacc
     9001 acgagataac tcctccctac ggggcttctg cttcgtagtt catcagcttt cgaccaatca
     9061 ttcgattcaa cttgaaattt gtgtcttatc cgatgttcca ccattttcaa cattttgtcg
     9121 tacaggatag taggtggata atggcccagc tacctgctag tactatgagc agcctcgttc
     9181 ggacttgcac cgattagttt tacctaagta agctaaccgg cgaattcgtc attgcacggc
     9241 ggagatgtgc tccgactcgc cccagatcac gtctcgcgcg cttccgccaa agccatcgat
     9301 aacatggtca tccgatgtgt cggtatgctc cagcacaagc acgcaaatat gcttgtcctg
     9361 gcggttgccg cccaatctgg cgatgacggg cgcttgagcc tgccgcagcg cttcattcac
     9421 tggctcgatc agctcggacg taaaaagctc cagcctcgtc gcgtatgttc cctggggaat
     9481 gctcgcctcg tactcggtac cgtctacctg gaaaataaac gtgttattcg tccccttgat
     9541 gacaatcggt tcggtatgca gggccgccga gccccatacc tgcgttcctc tgctgctcat
     9601 gtgatcatcc ttcctttctg attgttggcc cgttaccctg ttcatgctgt ctctgatcgt
     9661 tattctgttc attcttctcg ttatcttgtt cctgttgccg ctgctgctgt tccctcgttt
     9721 tcaaaatcgc aataatctgc ttgatctgcg gcggcaaagg cagcccaatc cgcccggagt
     9781 tctccgcaat gctgatcacc tcattggaaa tgtaaaacca tatcgcgccg tacatgagaa
     9841 aatcgctctc cagcgccaca tcggcccgat gagcgagcag cacgacgacg aacatcaagc
     9901 cttttttggc cagtccggca aagcccttct tgctgctcaa cccggcctgc ggcatccctc
     9961 tggccgcttc cattacggag gctgcatagc cgctgatgta atccataagc gccaacaacg
    10021 ccagaaactc aagcaagctg ctccctcccc catacaagta gctcatcaag ccgccgatga
    10081 atccgatact gctgttcact attttgtcgt acacccgatc cctccttgct catcgacagc
    10141 catctctcgg aaaaagaaag gagccatccg gtgaaggacg gctcacaata tgggttcctg
    10201 ctacaaaata taatagtatg cgccgcctgc gctgccgacg gtaatgacac catgcaaatc
    10261 tcctgcatcc cgctgtcgga tcagggctgc cgcatggcag tcctcctccg caatgaccct
    10321 tggcgcgaga tagccgtgaa gatccggaac gctgacccga agggcgccct ccacctcatc
    10381 aatcgcgtgt acaacgagga aggccttcag ctccgacggc agcttaatca ggacggtact
    10441 gtccagcgtc tgttcatgct tcacatagag atgcgtctcg atggaagaag catgcttcac
    10501 gtccagagcg gctggaacct ctgggcggga cgccgcaagc gaggcgcgat gatcctcata
    10561 gtgcggcacc tcgatctggc ctgccatctc ccgctcaccc agcgcccgaa tcatcagccc
    10621 cgcatgcata tccggcttgg atacggttgc ccgggactcg atatccgaat cccttccttc
    10681 acgaatgctc aggctcgctg ctgtatcgct gctatgctta tgatagagcg atacttccac
    10741 atacgcaggc agcgcaggga cagaagccgt aatggatgat tccggcccct cggattcctt
    10801 cttcataacc gtaagagagc aagccaggct tatgttcgga tcaaccgtga tgcaaacggg
    10861 cttgtccgga gtgctggccg ccatgatcac cctgcgctcg cttgccccgt ctctgcgaat
    10921 cgtgcagctt gcctctagct ctggatattc ccgaatcgct accgtcagcg ctgccgggtg
    10981 aaccggcctg gacacgagca gcaagccttc ctgccattcg aacatcggat cggcaggctg
    11041 atgcacatag agcgccgctg tccgatcgtc cgcgccgcgg tcgctatgga ccgtaaggct
    11101 ggccctccgc tcggatcctc caactccgta gacgaatacg gaggcgtcaa tcgcgcttct
    11161 gccgatgctg tacacttggt tcgggatata gcggagctgg agcacgggcg gcttgtgaga
    11221 ttccctcgta
//
