LOCUS       NZ_AP025344            23888 bp    DNA     circular CON 24-MAR-2024
DEFINITION  Paenibacillus dendritiformis strain J27TS7 chromosome, complete
            genome.
ACCESSION   NZ_AP025344
VERSION     NZ_AP025344.1
KEYWORDS    RefSeq.
SOURCE      Paenibacillus dendritiformis
  ORGANISM  Paenibacillus dendritiformis
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1
  AUTHORS   Okumura,K., Okamoto,M. and Takamatsu,D.
  TITLE     Whole-Genome Sequences of Bacillus and Paenibacillus sp. Strains
            Isolated from Honey in Japan
  JOURNAL   Microbiol Resour Announc 11 (11), e0084222 (2022)
   PUBMED   36301092
  REMARK    DOI:10.1128/mra.00842-22
REFERENCE   2  (bases 1 to 6547390)
  AUTHORS   Takamatsu,D., Mada,T., Okumura,K. and Okamoto,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2021) Contact:Daisuke Takamatsu National Institute
            of Animal Health,NARO; Kannondai3-1-5, Tsukuba, Ibaraki 305-0856,
            Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3
            Genome Coverage                   :: 124x
            Sequencing Technology             :: PacBio; NovaSeq 6000
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_021654795.1-RS_2024_03_24
            Annotation Date                   :: 03/24/2024 09:12:59
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,875
            CDSs (total)                      :: 5,765
            Genes (coding)                    :: 5,679
            CDSs (with protein)               :: 5,679
            Genes (RNA)                       :: 110
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 82
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 86
            CDSs (without protein)            :: 86
            Pseudo Genes (ambiguous residues) :: 0 of 86
            Pseudo Genes (frameshifted)       :: 39 of 86
            Pseudo Genes (incomplete)         :: 62 of 86
            Pseudo Genes (internal stop)      :: 15 of 86
            Pseudo Genes (multiple problems)  :: 26 of 86
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:45:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 189537
            Orig. end                         :: 213425
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP025344.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotated by DFAST https://dfast.ddbj.nig.ac.jp/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23888
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..23888
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23888
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13888](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13888)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            32..1216
                     /db_xref="GeneID:73382712"
                     /locus_tag="L6439_RS00880"
                     /old_locus_tag="PsJ27TS7_01750"
     CDS             32..1216
                     /codon_start=1
                     /db_xref="GeneID:73382712"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006678408.1"
                     /locus_tag="L6439_RS00880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PsJ27TS7_01750"
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_213468582.1"
                     /sec_met_domain="NTP_transf_5 (E-value: 4.7e-62, bitscore:
                     208.1, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKSLILDTDMLTNEMKLILEIISSDRPEDLRKDKAGLFQDCKWE
                     AFLRLAMHHRVYSVLYMQMKDMGDDMVPPAVIQRLYRQYSANTLRMLHLSSEIEHIGKE
                     LAGGGLRCLFLKGPVLGQELYGSVSLRACSDLDLLVPFAELVRAETILITLGYEKDDYI
                     ESVLGDWKWRHHHLTFLHPVKGIKVELHWRLNPFPSKEPSFNELWLRRRRSTLFGSPIY
                     YLGREDLFVFLVTHGARHGWSRLRWLLDIKQLLNQQPDHGQIMNRLRRRRCVRAGGQSV
                     VLASSLLQAPLAPELHRLASRRRSVRLAQDAMFYLSQMVHLHKEPVPEEVGAYHKRHLF
                     ALMPLRHKCLFILSFMLPYPEDVKVIRLPRMLHYIYIPLRPFLWAWRKSAGVQK"
     gene            1213..2415
                     /db_xref="GeneID:73382713"
                     /locus_tag="L6439_RS00885"
                     /old_locus_tag="PsJ27TS7_01760"
     CDS             1213..2415
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:73382713"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006678407.1"
                     /locus_tag="L6439_RS00885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PsJ27TS7_01760"
                     /product="glycosyltransferase"
                     /protein_id="WP_168180014.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 7.4e-25,
                     bitscore: 85.9, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRVLFASFDMEVGGVERSLAGLLEHFDYERYQAEVMLYRHQGDF
                     MALLPEQVRLLEEQRAYATFRKSIGDILKSRQLLIGLGRLTAKVHADMAGKARGLAETG
                     YHQMQLMWRYTLPFLPRNTQLYDAAVSFLWPHYYVAEKVDARTKIAWIHTDYSTVATNV
                     RSDLKLWSKFDHIIAVSPSCREAFLAKYETLRDKVTVIENIISPDYIKMMSGESVDSPM
                     AADPRFKLVTVARLSHAKGIDQAVMALKKLREKGLEDIAWYVVGYGGDEEMIRGLIAKN
                     RLQDDFILLGKQYNPYPFIKQADLYVQPSRYEGKAVTVTEAQILGKPVLITRYPTAQSQ
                     VADGLDGYITDLSVEGLAEGIEHLYRDRQLRCRLADMCSRTQYGNAGELNKLYALLDDN
                     G"
     gene            2427..3398
                     /db_xref="GeneID:73382714"
                     /locus_tag="L6439_RS00890"
                     /old_locus_tag="PsJ27TS7_01770"
     CDS             2427..3398
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:73382714"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006678406.1"
                     /locus_tag="L6439_RS00890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PsJ27TS7_01770"
                     /product="polysaccharide pyruvyl transferase family
                     protein"
                     /protein_id="WP_213468583.1"
                     /transl_table=11
                     /translation="MDNILLLDTSVGSLNKGDEIIMKCVRRQLSGITRQANVFTVPTHL
                     SPFGWFQVMRDSLRVQFYTRAKYKFVGGTNLLTMDMFTHFPQWNINVFNYRPLQGSILL
                     GVGAGKGEKIKRYTKMLYRKVLSHEYVHSVRDERTWRFVTDLGLKALNTGCPTMWALTP
                     EHCRDIPRGKSDAVVFTLTDYARAPRQDQLLIDLLIRSYRKVYFWVQGADDYAYFHTLS
                     NTEGIHVIPPSLEEYEAVLSTDVDFVGTRLHAGIYAMRHKKRSIIIAVDERARGMSETY
                     ALNTVDRTDLAGLEAMIHSEFATNVRINLEAIQAWLDQFKQR"
     gene            3423..4688
                     /db_xref="GeneID:73382715"
                     /locus_tag="L6439_RS00895"
                     /old_locus_tag="PsJ27TS7_01780"
     CDS             3423..4688
                     /codon_start=1
                     /db_xref="GeneID:73382715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006678405.1"
                     /locus_tag="L6439_RS00895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PsJ27TS7_01780"
                     /product="peptidase"
                     /protein_id="WP_168180012.1"
                     /transl_table=11
                     /translation="MIQLTREQIKVNQNRVDYFFQVDPRLQKYFRASNHLFMKYNYDIS
                     GLPASILSIPFAANMMPLAWLTDATLYVDELDRSFYDCLAELKQAYQEMFPHFPLKGQI
                     KVGQVSSYDYQPEHEAAVLFSGGLDALTTYIRHREKKPFLITEYGWHEGDCTDSEVWTA
                     DREHAEAFARKEGLSNILVESNYGTFVYPQRIDRDFRRSLGDTWWHGLHHGLAIISAAV
                     PAACLLQVKTIYIASSHTIGNTYSCASDPSTDNLIRYGTGDVFHDGYELSRQDKVKVVV
                     DHYAAANDKTAVRVCYRNTENCCQCEKCVRTIMGIAAEGHDPNDYGFPVPDELSGFLKR
                     FLKREVKFFTNIQIERLWKPIQERMRENPDNVKDPDLLSWFPDYDFVAHRRKERFRYRV
                     TQFFPIIRRKVRTGLQQIRETR"
     gene            4705..6267
                     /db_xref="GeneID:73382716"
                     /locus_tag="L6439_RS00900"
                     /old_locus_tag="PsJ27TS7_01790"
     CDS             4705..6267
                     /codon_start=1
                     /db_xref="GeneID:73382716"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001222557.1"
                     /locus_tag="L6439_RS00900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PsJ27TS7_01790"
                     /product="sugar translocase"
                     /protein_id="WP_168180011.1"
                     /sec_met_domain="Polysacc_synt (E-value: 4.6e-11, bitscore:
                     41.1, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIRNSLYNIFFGLLGQAISTIMGFIVRTVFIWTLGVEYLGVSGL
                     FSDVLMLLSLANLGFETAIIYSLYQPLADRDEARIKAFMHLFRKAYLFIGMIVLLLGLS
                     LIPFLDVFIQGETTVSHLELIYVLFLLHSVSTYFFAYKQAIIVADQQQHVISRIHSVYV
                     IAMNTIQIIVLLCTKNYILFLVIQIGMSVLRNKYISRVADRKYEFLREPLSTPLDKGEK
                     KTFFQNLRSLLMYKVSGVVINGTDNLIIANLFGVIWVGLYSNYYLILTTLTTFLSYFFY
                     SLTASVGNLNATEDKEKKFFFYCVLRLANFWVFGLCAVCLWNLLDPVIILWLGGSFVLG
                     KETLLAILLNFYTTGMQNASTMFRDTTGMFRRGRYSPLIAAAMNIALSITLARFIGMPG
                     VFLGTVISRLLTYFWVDPYLLHKHVFFQPLRPYFTRYALHAALVLLAASFCGWIAGLFT
                     LPLLWDIAVRVLLCLTVTNLIFYACFRKSREFIYLTNIAKANLGKLSILTKFNPVIRRE
                     ETR"
     gene            6267..7295
                     /db_xref="GeneID:73382717"
                     /gene="galE"
                     /locus_tag="L6439_RS00905"
                     /old_locus_tag="PsJ27TS7_01800"
     CDS             6267..7295
                     /EC_number="5.1.3.2"
                     /GO_function="GO:0003978 - UDP-glucose 4-epimerase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006012 - galactose metabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (4-199). E-value: 3.4e-08.
                     Score: 24.8. Matches aSDomain:
                     nrpspksdomains_L6439_RS00905_NAD_binding_4.1"
                     /codon_start=1
                     /db_xref="GeneID:73382717"
                     /gene="galE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006678403.1"
                     /locus_tag="L6439_RS00905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PsJ27TS7_01800"
                     /product="UDP-glucose 4-epimerase GalE"
                     /protein_id="WP_213468584.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.4e-13, bitscore:
                     48.2, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 2.2e-14,
                     bitscore: 51.7, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAIMITGGAGYIGSHTCVEMLEAGYEIVVLDNFSNSHPEAIRRIS
                     DITGKGFAFYEADLLDEQRLNRIFEGHRIDAVIHFAGLKAVGESVQVPLDYYHTNLTST
                     LVLCRAMARHGVYKLVFSSSASVYGAPDCVPISEEASLGAVSPYGRTKQMIEQVLQDLA
                     SSDPRWGISILRYFNPVGAHKSGKIGESPNGTPNNLMPFITQVAVGRLPSLKIYGSDYP
                     TKDGTGIRDYIHVVDLAQGHLKALEHLDHTNGVECYNLGTGQGVTVLEMIHSFEKVSGV
                     QIPYEIVGRRPGDVAICYADPTKYLLNLGWFPKYGIIDMCEDSWNWQVHNPQGYCERIT
                     AG"
     CDS_motif       6276..6338
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_L6439_RS00905_0001"
                     /evalue="4.90E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="L6439_RS00905"
                     /protein_end="24"
                     /protein_start="3"
                     /score="12.8"
                     /tool="antismash"
                     /translation="MITGGAGYIGSHTCVEMLEAG"
     aSDomain        6279..6863
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_L6439_RS00905_NAD_binding_4.1"
                     /evalue="3.40E-08"
                     /label="L6439_RS00905_NAD_binding_4.1"
                     /locus_tag="L6439_RS00905"
                     /protein_end="199"
                     /protein_start="4"
                     /score="24.8"
                     /tool="antismash"
                     /translation="ITGGAGYIGSHTCVEMLEAGYEIVVLDNFSNSHPEAIRRISDITG
                     KGFAFYEADLLDEQRLNRIFEGHRIDAVIHFAGLKAVGESVQVPLDYYHTNLTSTLVLC
                     RAMARHGVYKLVFSSSASVYGAPDCVPISEEASLGAVSPYGRTKQMIEQVLQDLASSDP
                     RWGISILRYFNPVGAHKSGKIGESPNGTPNNL"
     CDS_motif       6579..6635
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_L6439_RS00905_0002"
                     /evalue="9.70E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="L6439_RS00905"
                     /protein_end="123"
                     /protein_start="104"
                     /score="8.6"
                     /tool="antismash"
                     /translation="LVLCRAMARHGVYKLVFSS"
     regulatory      7385..7467
                     /bound_moiety="cyclic di-GMP"
                     /db_xref="RFAM:RF01786"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF01786"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cyclic di-GMP riboswitch class II; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /regulatory_class="riboswitch"
     gene            7485..7655
                     /db_xref="GeneID:73382718"
                     /locus_tag="L6439_RS00910"
                     /old_locus_tag="PsJ27TS7_01810"
     CDS             7485..7655
                     /codon_start=1
                     /db_xref="GeneID:73382718"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018707844.1"
                     /locus_tag="L6439_RS00910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PsJ27TS7_01810"
                     /product="anti-repressor SinI family protein"
                     /protein_id="WP_168180009.1"
                     /transl_table=11
                     /translation="MVEAVPGNNEQLDKDWVAIILTARQMGLSIEDIRKLLRDFQAQSN
                     PEWPLHVNSEA"
     gene            complement(7778..8113)
                     /db_xref="GeneID:73382719"
                     /gene="sinI"
                     /locus_tag="L6439_RS00915"
                     /old_locus_tag="PsJ27TS7_01820"
     CDS             complement(7778..8113)
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:73382719"
                     /gene="sinI"
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_023855185.1"
                     /locus_tag="L6439_RS00915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PsJ27TS7_01820"
                     /product="DNA-binding anti-repressor SinI"
                     /protein_id="WP_006678401.1"
                     /transl_table=11
                     /translation="MIGERIQILRRKKNYSLSELSERAGVAKSYLSSIERGIQQNPSIQ
                     FLEKISVILGVSVEELLQDKEASNEAEALDEEWTNLVKEAMASGVSKEQFKEFLEYNKW
                     KLTREES"
     gene            complement(8181..10004)
                     /db_xref="GeneID:73382720"
                     /locus_tag="L6439_RS00920"
                     /old_locus_tag="PsJ27TS7_01830"
     CDS             complement(8181..10004)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:73382720"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006678400.1"
                     /locus_tag="L6439_RS00920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PsJ27TS7_01830"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_213468585.1"
                     /transl_table=11
                     /translation="MNSITLYMKRLHKTAGLRLSINIIGMVISSLLEGMTFLLLIPMLT
                     VGGVLLSEPAWENRLQFLNILHSLPQASSLAIILTVYLLIVVIQNLIHRAVTIRNAEIE
                     QHFSRQLRYENYSALLRAQWSFFLHRRTSDLVNALTIETARVLGGISLLLQFITSALFT
                     LVQIIFAFWISPTITLFVIACGAMLAFLSRGFIRKSKQLGSHTSKLAQAYLAGITDQLQ
                     GMKDIKSNNLEPSRLEWHQQLTEGTMQEQLDYVRLRLNSQLLYKISSSLLIAGFIFVSF
                     RFFPAEGPSLLIVILVFARLWPRFTSLQSKLEQLASTIPAFKALQQLQHDCQLAADQAI
                     ALTESPAQGPGPWFVMQGIEVRNLSFRYQPQRPVYALQNISVHIPAQGMTAIVGKSGAG
                     KSTLIDLLMGLMQPESGQILVDGMAITNENLLAYRRSIGYVAQDPFLYNASIRENLLMV
                     KPSATENDLWEALDFSSAAEFVRKLPHQLETLIGDRGIRLSGGERQRLVLARAIIRQPS
                     ILVLDEATSALDTENEKKILTALHRLKERITVIVVAHRLSTIQNAEQILVMHDGKLVEQ
                     GTFLSLFSEKKSIFVNLLQNQEVNPVSVYPL"
     gene            complement(10001..10462)
                     /db_xref="GeneID:73382721"
                     /locus_tag="L6439_RS00925"
                     /old_locus_tag="PsJ27TS7_01840"
     CDS             complement(10001..10462)
                     /codon_start=1
                     /db_xref="GeneID:73382721"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006678399.1"
                     /locus_tag="L6439_RS00925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PsJ27TS7_01840"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_213468586.1"
                     /sec_met_domain="PF13471 (E-value: 8.3e-25, bitscore: 85.5,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRLRRWIWLCLFDRKTFLLFAEAYLYLGWARILLYFPFAKISPL
                     LGRRSMETPEVHDPSDTKTMKHIRSAIHIASRHTFWESKCLVRAIAGMKMLEKRNLNST
                     LYLGTGKNKNGELIAHAWLRSGSIYITGAEMMKQFVVVEKFAKSAGTDL"
     gene            complement(10459..10758)
                     /db_xref="GeneID:73382722"
                     /locus_tag="L6439_RS00930"
                     /old_locus_tag="PsJ27TS7_01850"
     CDS             complement(10459..10758)
                     /codon_start=1
                     /db_xref="GeneID:73382722"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006678398.1"
                     /locus_tag="L6439_RS00930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PsJ27TS7_01850"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_213468587.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.2e-22,
                     bitscore: 78.1, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.7e-13, bitscore: 49.1,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNLHSIAPVDTLVQCEGHIVSDMAGEKVMLSVQKGKYYNLGTLG
                     GEIWDMLVTPVKAEHIIRSILSDYEVEPPECEEDILLFLSDLEREGLIRLVKRL"
     aSDomain        complement(10477..10710)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_L6439_RS00930_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="5.80E-25"
                     /identifier="RREFam002.1"
                     /label="L6439_RS00930"
                     /locus_tag="L6439_RS00930"
                     /protein_end="94"
                     /protein_start="16"
                     /score="78.1"
                     /tool="antismash"
                     /translation="EGHIVSDMAGEKVMLSVQKGKYYNLGTLGGEIWDMLVTPVKAEHI
                     IRSILSDYEVEPPECEEDILLFLSDLEREGLIR"
     gene            complement(10755..11696)
                     /db_xref="GeneID:73382723"
                     /locus_tag="L6439_RS00935"
                     /old_locus_tag="PsJ27TS7_01860"
     CDS             complement(10755..11696)
                     /codon_start=1
                     /db_xref="GeneID:73382723"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016112625.1"
                     /locus_tag="L6439_RS00935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PsJ27TS7_01860"
                     /product="aldolase"
                     /protein_id="WP_213468588.1"
                     /transl_table=11
                     /translation="MTERAAVRTDHYKAFGFRIESDFALPELPQASEREPMDNITVRRT
                     DLQPLWNSTIHSYGNLAILDHGRTVMFRVPGAAIYAVQDGSSILVSPFDQAEEDWVRLF
                     ILGTCMGILLLQRKIMPLHGSAVAIDGKAYAIIGDSGAGKSTLALHLMSEGYPLLSDDV
                     IPVVMTQGSPWVVPSYPQQKLWADTLKHMGMDNASYTPLYERNTKFAVPAGSNFHDEPL
                     PLASIFELVPWDAATHSAPIQGLDRLRVLFHHTYRNLLVQPLGLMEWHFKTLTSFVHQI
                     GMYRLHRPMVGFSALDLTSVILNITRQGENDQ"
     misc_feature    complement(11713..11727)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 20.9"
                     /tool="antismash"
     gene            complement(11799..11936)
                     /db_xref="GeneID:73382724"
                     /locus_tag="L6439_RS00940"
                     /old_locus_tag="PsJ27TS7_01870"
     CDS             complement(11799..11936)
                     /codon_start=1
                     /db_xref="GeneID:73382724"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002172970.1"
                     /locus_tag="L6439_RS00940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PsJ27TS7_01870"
                     /product="paeninodin family lasso peptide"
                     /protein_id="WP_213468589.1"
                     /transl_table=11
                     /translation="MKKPYSKPSLEVLDVHQTMAGPGTSTPDAFQPDPDEDVHYDPMDS
                     "
     CDS_motif       complement(11877..11936)
                     /prepeptide="leader"
                     /note="peptide class: lassopeptide"
                     /note="predicted sequence: MKKPYSKPSLEVLDVHQTMA"
                     /locus_tag="L6439_RS00940_lassopeptide"
                     /aSTool="lassopeptides"
                     /tool="antismash"
     CDS_motif       complement(11799..11876)
                     /prepeptide="core"
                     /locus_tag="L6439_RS00940_lassopeptide"
                     /peptide="lassopeptide"
                     /predicted_class="Class II"
                     /score="-9.90"
                     /molecular_weight="2672.7"
                     /monoisotopic_mass="2671.1"
                     /core_sequence="GPGTSTPDAFQPDPDEDVHYDPMDS"
                     /aSTool="lassopeptides"
                     /tool="antismash"
                     /leader_sequence="MKKPYSKPSLEVLDVHQTMA"
                     /leader_location="[11876:11936](-)"
     gene            complement(11939..13888)
                     /db_xref="GeneID:73382725"
                     /locus_tag="L6439_RS00945"
                     /old_locus_tag="PsJ27TS7_01880"
     CDS             complement(11939..13888)
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:73382725"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006678396.1"
                     /locus_tag="L6439_RS00945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PsJ27TS7_01880"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_213468590.1"
                     /sec_met_domain="GATase_7 (E-value: 1.7e-18, bitscore:
                     65.1, seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 4.4e-25, bitscore:
                     87.5, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGAIAGLYHLQHDKLEPGLGREMIDALRRFPADYISSWSNGSLFL
                     GCLQQCITPQSINEVLPCYDPVTSLAITSDAMIDNRDELADQLQLSKQALQTITDSQLI
                     LQAYMKWGHDMPKHLVGDFAFIIWDGRDRTMFGARDFSGTRTLYFHQSPELLSFCTVME
                     PLLKLPHVKRDLNERWISQFLAIPITTDAVDSFSTVYQSIKQVPPSHSIFVANGKVIFQ
                     QYCRLRHSDKLVLASNEEYEEAFRDVFQTAVHARLRTCRHVGAHLSGGLDSGSVVSFAA
                     PMLRAINKPLYTFSYYPVEGFSDFTSGSRFADEREYIRSTAEHAGNIEMNVSSYPASNP
                     YSVIDEWLDTLEMPYKFFENSFWLKGIYEQASAQGIGIMLTGQRGNWTISWGPAMDYQA
                     SLLRKGRLVSFFWEYRRYCQSLGANPWKVLQIVGKKSFPWLAPLIAPGSDPALPVLINP
                     EFASKTNVTDCMKACGMDVWGSSTQNAYDIRKDHFNQLYFWNINGTIGTKLSLKHKIWD
                     RDPTNDLRVVRFCLSVPDEQFVQQGVDRSLIRRATARYLPDKVRLNRKRRGVQGAYGVF
                     RLMPEWSGLIREFEQMIGDPRTSYYLNAPLLQELLDDIRDYPRPELAFDLKFRVLMRGF
                     IFHKFLSRISGKEV"
     gene            14237..15199
                     /db_xref="GeneID:73382726"
                     /locus_tag="L6439_RS00950"
                     /old_locus_tag="PsJ27TS7_01890"
     CDS             14237..15199
                     /EC_number="2.7.8.-"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:73382726"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_4"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006678395.1"
                     /locus_tag="L6439_RS00950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PsJ27TS7_01890"
                     /product="MraY family glycosyltransferase"
                     /protein_id="WP_168180002.1"
                     /sec_met_domain="Glycos_transf_4 (E-value: 1.1e-39,
                     bitscore: 134.4, seeds: 116, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFSYVFAFLLSACIVLFLIPPFKKLAFRIGFVDQPQADNERKIHR
                     QPIPLLAGAAIFIGFCITYVSFVPHSLTKMAGILGGGLLILSIGMVDDWYKTRRKDFPA
                     LPKLIVQVGAAALVYASGIAFIGFNNPFTGQFIYLPEWLQFLLTVTWIFGVTTVINFSD
                     GMDGLAGGLTAISAGTLFIVGISHGQGTPAMMALILVGAAIGYLRYNKPPANVFMGDAG
                     ATFLGFMLGVVALDGAFKQATLLSLFIPILAVGVPIFDNILVVFRRMLNGQPIYKADAT
                     QAHYRLLAVGLNQKQVVIFLCLLNLCFGLTSIILSLLPV"
     gene            15292..16350
                     /db_xref="GeneID:73382727"
                     /locus_tag="L6439_RS00955"
                     /old_locus_tag="PsJ27TS7_01900"
     CDS             15292..16350
                     /codon_start=1
                     /db_xref="GeneID:73382727"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006678394.1"
                     /locus_tag="L6439_RS00955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PsJ27TS7_01900"
                     /product="suppressor of fused domain protein"
                     /protein_id="WP_168180001.1"
                     /transl_table=11
                     /translation="MTEEEAQALGWDAIDAKLKEVYGDTEPLHYGTVLPYMLGGEDPLD
                     GISVFAQAEPEPHWHYVTYGFSELYEKEGDDPEISGYGFELTMRLKREGEEEPPAWPMN
                     MLQNLARYVFRSGNVFAAGHYLDANGPIALDSDTEMRALFFMRDSQLGEMDTPNGSVQF
                     LQVAGITLDELDMMQSWRSSGFLPMMEEVLPLGITDLKRTSVLRDPDTAARAEEGMRRD
                     GSGTGSLFIDSLAWQEEKKFMRGAVYTIEIGAKQAPSIAQILRGRIPYREALYLIGPNR
                     PIACLPGDEPQAVVQDDALELHLNEQALEELASRLVPRQGTFTIASLPKVQFHIVKTEI
                     RNQDGEVVKTIG"
     gene            complement(16515..18383)
                     /db_xref="GeneID:73382728"
                     /locus_tag="L6439_RS00960"
                     /old_locus_tag="PsJ27TS7_01910"
     CDS             complement(16515..18383)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009166 - nucleotide catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:73382728"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1283: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005550349.1"
                     /locus_tag="L6439_RS00960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PsJ27TS7_01910"
                     /product="5'-nucleotidase C-terminal domain-containing
                     protein"
                     /protein_id="WP_213468591.1"
                     /transl_table=11
                     /translation="MNKKKLGTAAVLTTLISALFAGSLFAAPIRPIDHIQWMQDKNYIF
                     GTKDGLALDRPITLVEAIAMLARVQGAAESVKTADPAFKHWAATSLTWAKQEGIVDAEQ
                     WKELHHPAPAATLQSVAERAGLRLELAGDTVTRDQFFKALGGAVTTHVTIGHTNDLHGH
                     VLEDAKAKEMGYAKLATLMKDLREENPNTMLLDAGDMIQGTIYVNLSKGETATKLANAL
                     GYDFMASGNHEYDFGHEQLARLTKMFEFPVLAANVFDAEGKPMLQPYVTKQVGGKTFAI
                     LGLVTKDTPIVTHPDNVKGLTFRDPIEVAKEWVPKLRQVADHVIVLCHTGLEYDREMAK
                     QVPGIDIIVGGHTHTPVDEPELVNSTYIVQDWEYAKSLGRVDLYYHGEDLVHFSGGLLK
                     YDETTKPDPDVAAIVESLKKETDALLNEKIATASVDLDGDRSRVQKQETIMGNLVADAM
                     LERTRTMPGLEADLAITNSGGIRTTIMKGDVTKRNLYDVLPFPNTLAVVEVKGSDLKAA
                     LENGVSEIESGSGRFPQIAGMSFDFDLKQPKGSRVTDVKVGGKALEEDRTYHVATNDFL
                     IAGGDGYSMFMNKKSLDTGVTLYEVVEQYMKAKKEITGKIEQRIRQ"
     gene            complement(18632..19663)
                     /db_xref="GeneID:73382729"
                     /locus_tag="L6439_RS00965"
                     /old_locus_tag="PsJ27TS7_01920"
     CDS             complement(18632..19663)
                     /EC_number="1.17.4.1"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009263 - deoxyribonucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:73382729"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013308516.1"
                     /locus_tag="L6439_RS00965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PsJ27TS7_01920"
                     /product="ribonucleotide-diphosphate reductase subunit
                     beta"
                     /protein_id="WP_172878916.1"
                     /transl_table=11
                     /translation="MKLQKIFNTEAPNQSTRIILGECSGILNWDDIRMPHMYKLYKVLL
                     LNHWIADEIPMSKDAQQFPNLTPDEQRAFKINISLLAVLDSMQTMFVGDVKRFFTDSSL
                     EAISAIIAQQEVVHNQSYSYVLSSLVSEQEQKDIFEYWKHDAVLLERNRFIADIYQTFR
                     DNPTPQTFFEALVADLILEGVFFYSTFAFFYNLARDQKMMATSQMISYIQRDENQHCYF
                     FGEVFKQLLRDFPELNTDENRRFVYETIDRAVQLETNWAHYTLSNIRGIDLRELSDYIK
                     YIANRRLAMMGMEKAYEGVDVNCMPWIKPFSDEALNSTKTDFFEAKSRTYGKVGDDNGF
                     DEL"
     misc_feature    complement(19706..19719)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 20.08"
                     /tool="antismash"
     gene            complement(19813..22164)
                     /db_xref="GeneID:73382730"
                     /locus_tag="L6439_RS00970"
                     /old_locus_tag="PsJ27TS7_01930"
     CDS             complement(19813..22164)
                     /EC_number="1.17.4.1"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:73382730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006678391.1"
                     /locus_tag="L6439_RS00970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="PsJ27TS7_01930"
                     /product="ribonucleoside-diphosphate reductase subunit
                     alpha"
                     /protein_id="WP_213468592.1"
                     /transl_table=11
                     /translation="MLTTNHTVQTVHKPNNRSLAFDAERILRYGERIMGEYPRLDRERW
                     HRGVLAKLRHSQVQASDITQACIMTALELVSVEEPQWKFVAARALLTKLYKEAALHRSY
                     KAYADRPYGDFYKLVKQLADIGIYRQELLEAYTPDQIRELGQAIVPACDELFDYIGLLT
                     LAERYLAVDFEGRTMELPQERYMIIAMYLMHQEPEERRVELAKEAYWAMSNLYMTAATP
                     TMANAGKKVAGQLSSCFIDTVDDSLEGIFDSNTDVARLSKMGGGIGVYLGKVRARGSDI
                     RGHKNTSSGVIPWIRQLNNTAVSVDQLGTRKGAIAVYLDVFHKDILSFLDLKLNNGDER
                     MRAHDIFHGVCIPDLFMEAVEKREDWHLFCPHEVKKTMGWADGNGRPLGLEDFYDEQAG
                     QGQFREKYAEAVANPRLSRITLPAIDIMKRILKSQLETGTPYMFYKDTANRANPNKAHG
                     TIYCSNLCTEIMQNMSPTTIEQEELVLEDGRARIIISKIPGDFVVCNLNSIHLARAVRA
                     GVLERLVPIQVRMLDNVIDINNIEVLQAQHTNRRYRAIGLGTFGLHHLLALEGIAWESD
                     EAVEYNDHLYERIHYLAVRASMELAKEKGAYPLFAQSEWENGRYFEQREYTTGTRPGRF
                     VTTDQWKELAAEVKANGMRNAWLMAVAPNGSTSIIAGSTASIDPVYELLSYEEKTTYKI
                     ANPAPDLSDKTMWYYKTAFRLDQNWSIRMAGARQRHIDQGQSFNLYVRPDIRAVDFLNL
                     HLHAWKAGLKSTYYVRSQALTVEECEACSS"
     gene            complement(22158..22346)
                     /db_xref="GeneID:73382731"
                     /locus_tag="L6439_RS00975"
                     /old_locus_tag="PsJ27TS7_01940"
     CDS             complement(22158..22346)
                     /codon_start=1
                     /db_xref="GeneID:73382731"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="L6439_RS00975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="PsJ27TS7_01940"
                     /product="hypothetical protein"
                     /protein_id="WP_168179998.1"
                     /transl_table=11
                     /translation="MRTAFGGERSCVVAGELRLVLLMRSRHHKKPPDTYGFAMPFLSCS
                     REGTAIFIVLFEEEYGC"
     regulatory      complement(22389..22661)
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(22448..22467)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: medium, score: 24.66"
                     /tool="antismash"
ORIGIN
        1 gcgagcgata tctgactgaa ggagtaagtt catggagaag tcccttatct tggacacaga
       61 catgctgacg aacgaaatga agctgattct ggagattatc tcaagtgatc gtcccgagga
      121 tttgcgcaag gacaaagccg ggctctttca ggattgcaag tgggaagcat ttttgcgcct
      181 tgcgatgcat caccgagtct attccgtgct gtatatgcag atgaaggata tgggcgatga
      241 tatggtgcct ccggcggtca ttcaacgtct gtaccgccaa tatagcgcca atacgctccg
      301 aatgcttcat ctgagcagcg agatcgaaca tatcggcaag gaattggccg gaggaggcct
      361 gcgttgttta tttttgaagg gacctgtgct tggtcaggag ttgtatggaa gcgtctcgct
      421 tcgcgcctgc tcggatctgg atctcctcgt ccccttcgcc gaattagtca gggcggaaac
      481 gatacttatc acgttagggt acgagaaaga tgattacatt gagtccgtac tgggggactg
      541 gaaatggcgg caccaccatc tgaccttttt gcacccggtc aagggcatca aggttgagct
      601 tcattggcgg ctgaacccgt tcccgtccaa ggaaccgagc tttaacgagc tgtggctcag
      661 gaggcgaaga agcacgctgt tcggcagccc catctattat ttgggcagag aggatttgtt
      721 cgtctttctc gtgacccacg gcgcccgcca cggctggtcg agattgcgct ggctgctcga
      781 tatcaagcag cttcttaacc aacagccgga tcacggccag atcatgaata gattgaggcg
      841 gcgccgatgt gtgcgtgccg ggggacaatc tgtcgtgctg gcctcatcgc tgcttcaagc
      901 gccgttggcg ccggaactgc atcggcttgc aagcaggcgg agatcggtgc ggctggccca
      961 ggacgccatg ttctatctgt cgcagatggt tcatctccat aaggagccgg tgcctgaaga
     1021 agtcggagcc taccataagc gccatctgtt cgcgttaatg ccgctgcggc ataaatgctt
     1081 gttcattcta agcttcatgc tgccttatcc cgaggatgtc aaagtcattc gattgccgag
     1141 aatgcttcat tatatctaca ttcccttaag gcccttcttg tgggcatgga gaaaaagcgc
     1201 aggtgtacag aaatgaaaag agtactgttc gcatccttcg atatggaggt tggaggagtc
     1261 gagagaagcc tggccggttt gctggagcat tttgattatg aacgctatca ggcggaggtg
     1321 atgctatacc gccatcaagg cgattttatg gctttgctcc ccgaacaagt ccggttgctg
     1381 gaggagcaac gagcctatgc caccttccgc aagtccatcg gcgacattct caagagccgg
     1441 cagctgttga tcgggctcgg aaggctgacc gcaaaagtgc atgccgatat ggccgggaaa
     1501 gcgagagggc ttgcagaaac gggatatcat cagatgcagc tgatgtggag atataccctt
     1561 cccttcctgc cccggaacac acagctctac gatgcggctg taagcttctt atggccccat
     1621 tactacgttg ccgagaaagt cgatgcccgc acgaaaatag cctggattca tacggattat
     1681 tctaccgtag ctacgaatgt gcgctctgat ttgaagctgt ggagcaagtt cgatcatatc
     1741 atcgccgtct ctccttcatg cagggaagcc ttcttggcaa agtacgaaac gctgagagac
     1801 aaggtgaccg taatcgaaaa cattatctct ccggactaca tcaagatgat gtccggggag
     1861 tctgtcgatt caccgatggc agcggatccg cgcttcaaat tggtcaccgt cgcccgtttg
     1921 tcgcacgcca aggggatcga ccaggctgtc atggccttga agaagctgag agagaagggg
     1981 cttgaggaca ttgcctggta cgttgtgggt tatggcgggg acgaggagat gattcgcggt
     2041 ctcattgcga agaatcggct gcaggatgat ttcattttgc tgggcaagca gtacaatccc
     2101 tatcctttca tcaagcaagc cgatctctat gtacagcctt cccgttacga ggggaaagcc
     2161 gtgaccgtaa ccgaagccca gattttgggc aaacctgttc tgattacccg ttatcctacg
     2221 gcacagagtc aggttgccga cggcttggac ggatatatta cggacttatc ggtcgagggc
     2281 ttggcggaag ggatcgagca tttatatcga gatcggcagc taagatgccg gctcgcggac
     2341 atgtgcagca ggactcagta tggcaatgcg ggcgaactca ataaactata cgcattgttg
     2401 gatgacaatg gataggaggc gaggctatgg ataacatcct gctgctcgac acctcagtcg
     2461 gttccttgaa taaaggggat gaaatcatca tgaaatgcgt gaggcgccaa ttgtccggca
     2521 ttacgcgcca ggccaatgtg tttaccgtgc ctacgcatct ttcccccttc ggctggttcc
     2581 aggtgatgcg agattcatta cgtgttcaat tctatacaag agccaaatac aagttcgtcg
     2641 gcggaacgaa tctattgacc atggacatgt tcacccattt cccgcaatgg aatattaatg
     2701 tgtttaatta tcgtccgtta caaggcagca ttctcttggg ggtgggggcg ggcaaaggag
     2761 aaaaaataaa acggtacacg aaaatgctct accgcaaggt gttgtcccat gaatatgtgc
     2821 atagcgttcg ggatgaacga acctggagat tcgtcacgga tttagggctc aaggcgttaa
     2881 atacgggatg tccgacgatg tgggcgttaa cgcccgagca ttgccgggat attcccaggg
     2941 ggaaatcgga tgccgtcgtg tttacgttga cagattacgc aagagcgccc cgtcaagatc
     3001 agctcctgat cgatcttctg attagaagct acaggaaagt atatttctgg gttcagggag
     3061 ccgatgatta tgcgtatttt catacgttat cgaataccga aggcattcac gtcattcctc
     3121 cttcgctgga agaatatgaa gctgtgctca gcacggatgt cgactttgta ggcacgcgcc
     3181 tgcatgccgg aatctatgcg atgcgtcaca agaaacgttc catcattatt gcggttgacg
     3241 aacgggccag aggaatgagt gagacatacg ccctgaatac cgtggaccgt acggatctcg
     3301 ccggccttga agccatgatc cattcggaat ttgcgacgaa tgtccggatc aacctggagg
     3361 ccatccaagc gtggctggat cagttcaagc agcggtaata ccggtcttga aggaggaagc
     3421 ccatgataca actgacgcgg gaacaaatca aagtaaatca aaaccgtgtg gactattttt
     3481 ttcaggtgga ccccaggctt caaaaatact tcagagcaag caatcattta tttatgaaat
     3541 ataactatga tatctcgggt cttcccgcaa gcatattgtc gattccgttt gcagcgaaca
     3601 tgatgccgct cgcgtggctt acggatgcga cgctgtacgt cgacgaactg gatcgttcct
     3661 tctatgactg tcttgcggaa ctgaagcagg catatcagga gatgttcccc cattttccgc
     3721 tcaaggggca aatcaaggtc gggcaggtgt cttcctatga ttatcaaccg gagcatgaag
     3781 ctgccgtgct atttagcggg ggcttggacg ccttgacgac ttatatccgc caccgggaga
     3841 agaagccttt tctcattacg gagtacggat ggcatgaagg ggactgtaca gacagcgagg
     3901 tatggaccgc agaccgtgag catgcggaag cttttgcccg caaggaaggg ctctccaata
     3961 tcctggtgga gtccaactac ggcaccttcg tctatcctca gcgaatcgac cgggatttcc
     4021 ggcgctcgct gggcgacacc tggtggcatg gactgcatca cggtctggcg attatatcgg
     4081 cagcggttcc tgcagcctgc ttgttacagg tgaagacgat ttacattgcg agctcgcata
     4141 cgatcggcaa cacgtattca tgcgcttccg acccgtcgac ggacaatctg attcgttacg
     4201 gaacgggcga tgtgttccat gacggatatg agctgtcccg gcaggataaa gtcaaagtgg
     4261 ttgtcgatca ttatgccgct gccaatgaca agaccgccgt ccgggtatgc tatcgcaaca
     4321 cagaaaattg ctgtcaatgc gagaagtgcg tcagaacgat catggggatt gcggcagagg
     4381 gccatgaccc gaatgactac ggttttccgg ttcctgatga gctctccggt tttttgaagc
     4441 ggtttttgaa gcgggaggtc aagtttttca cgaatatcca aatcgaacgg ttatggaagc
     4501 cgatccagga gcgcatgcgg gagaatcctg acaacgtgaa ggatccggat ctgctgtctt
     4561 ggtttccgga ttacgatttc gtggcccatc gaagaaaaga acggttccgc taccgtgtga
     4621 cgcaattttt cccgatcatc agaaggaaag tgagaacggg tttgcagcaa atccgtgaaa
     4681 ccaggtaaaa gagcaggtac agggatgaga attcgcaatt cgctttataa catttttttt
     4741 ggtctgctgg ggcaagccat tagcaccata atgggtttta tcgttagaac ggtttttata
     4801 tggacgcttg gcgttgagta tctgggagtg agcggcctgt tctccgatgt gctcatgctc
     4861 ctgtctcttg ccaatctcgg ttttgagacc gcgattattt acagcttgta ccaacctctt
     4921 gccgatcggg acgaggccag gataaaagct tttatgcatt tatttcgaaa agcctatctg
     4981 ttcataggta tgattgtgct cttgctgggg ctttccctga ttccctttct cgatgttttc
     5041 attcaggggg aaacgacggt ttctcatctc gaactcatct atgtgttatt tctgctccat
     5101 tccgtgtcca cctacttctt cgcttataaa caggccatta ttgtggccga ccagcagcag
     5161 catgtgatat cgcgaatcca tagtgtgtat gtcattgcca tgaacacgat ccaaatcatc
     5221 gtgcttctct gtacgaaaaa ctacattcta ttccttgtga tccagattgg aatgagcgtt
     5281 ctcagaaaca agtatatttc ccgcgtggcc gaccgaaagt acgaattcct gagggagccg
     5341 ctcagtactc ctctggacaa aggagagaag aagacctttt ttcaaaatct gcgctccctg
     5401 cttatgtaca aagtgagcgg cgttgtcatc aatgggacgg ataatctgat tattgcgaac
     5461 ctgtttggcg tcatatgggt cggactgtat tccaattatt atttgattct gacaacctta
     5521 actacgtttc tcagctattt cttctattct ctaacggcca gcgtagggaa tttgaacgct
     5581 acggaggata aggagaagaa gtttttcttc tactgtgtgt tacgcttggc caacttttgg
     5641 gtgttcgggc tttgtgccgt ctgtttgtgg aacttgctcg atcccgtgat tattttatgg
     5701 ctcggaggtt cttttgtcct cggcaaggag accttgcttg cgatcctgct caatttttat
     5761 acgacgggga tgcaaaatgc ttcgaccatg ttccgggata cgacaggcat gttccgaagg
     5821 ggaaggtaca gcccgttgat cgcagcggca atgaacatcg cattatcgat tacgcttgca
     5881 cgcttcatcg ggatgccggg agtgttcctc ggaacggtca ttagccggtt gctaacctat
     5941 ttttgggttg atccttattt gcttcataag cacgtattct ttcaaccgct gcgcccttat
     6001 tttacccgtt acgcactgca tgccgcgtta gttcttctgg cggcatcctt ctgcggctgg
     6061 attgcaggct tgttcacgct gccgctgtta tgggatatcg ccgtcagggt cctgctgtgc
     6121 ctgaccgtaa cgaacctgat cttctatgcg tgctttcgca aatcgaggga gtttatctac
     6181 ttaacgaaca tagccaaggc gaatctggga aagctgtcga tccttactaa attcaatccg
     6241 gtcatacgga gagaggagac aaggtaatgg ccattatgat cacgggtggc gccggttata
     6301 tcggaagcca tacttgcgta gaaatgctgg aggcgggata tgaaatcgtc gttcttgaca
     6361 atttctccaa cagccatccg gaagcgattc gccggatctc ggatattaca ggcaaaggat
     6421 ttgcttttta tgaagcggat ctcctcgacg agcaacgctt gaatcggata ttcgagggac
     6481 atcgcatcga tgccgtgatc cattttgccg gcctgaaagc ggttggggaa tcggttcagg
     6541 tgccgcttga ttactaccat acgaatctta ccagcacgct ggttctgtgc agggcgatgg
     6601 ccaggcatgg cgtgtataag ctggtattca gctcatccgc ctcggtatat ggggcaccgg
     6661 actgtgttcc catttcggag gaagccagcc ttggggcggt gagtccctat ggaagaacca
     6721 aacaaatgat tgagcaagta ctgcaggatc tggcttcttc tgacccgaga tggggaattt
     6781 ccattctcag atatttcaat cccgtcggtg cacataaaag cggaaagatc ggagagagcc
     6841 ccaatgggac gcctaacaat ttaatgccgt ttattacgca agtcgccgta gggagattgc
     6901 cgtcgctcaa aatatacggc tccgattacc ctacaaaaga cggaacggga atccgagatt
     6961 atattcatgt cgtggatttg gcgcaaggcc atctgaaagc attggagcat ttggatcata
     7021 caaatggggt cgaatgttat aacctgggta cgggccaggg ggttacggtg ctggagatga
     7081 tccattcctt cgagaaggtg tcgggggttc agattcccta tgaaatcgtg gggcgaagac
     7141 cgggggatgt cgcgatttgc tatgccgatc cgaccaagta cctattgaac ctgggatggt
     7201 tcccgaaata cggcatcatc gacatgtgtg aggatagctg gaattggcag gttcataatc
     7261 cgcaagggta ttgcgagagg atcacggccg ggtaatcacc gaattcgaca aaactagtgc
     7321 tccagagacg acatactatg acaccatgaa acgtcaaatg tcgtgtataa tgctacttaa
     7381 taagtatata ttaggaaacg atgaaatgcg cttttgtctg ggcactttag gcgcgtggag
     7441 ttagtggtgc aaccggccga gtaaattcgg gaggcaatgc aatcatggtt gaagcggttc
     7501 caggtaacaa tgaacaattg gacaaggatt gggtagctat tatcttaact gcacgacaaa
     7561 tgggcctttc cattgaggac attcgtaaac ttcttcgcga ttttcaggca caatctaatc
     7621 ccgaatggcc gctccatgtc aattcagaag cataactcgc gagcgttgac attagcgaaa
     7681 agaaatctcc tttgttgagg cgtgtttaca gataatgcgc ggtggactca acaatcggag
     7741 atttctttat tcctggctgc ctcaacgcta gtgggcatca cgactcttcg cgtgttagct
     7801 tccacttatt atattccaaa aattctttga attgctcttt gcttacgcca gaagccatcg
     7861 cttcttttac aagattagtc cattcttcgt ctaacgcctc agcttcattc gaggcttctt
     7921 tatcttgcag cagctcttca accgagaccc caagaataac gctaatcttc tccagaaatt
     7981 gaatggaagg attctgctga attcctcttt caattgagct taaataggat tttgcgacac
     8041 cggctctttc ggagagttct gacagtgagt aatttttctt ccttcgaagg atttgaatcc
     8101 gttctccgat catgatttaa cctccgtgta tacatctgct tgtccctatt atatccgatt
     8161 tgtgccacct ccgaaagcgg ctacaacgga tagacggaaa caggattcac ctcctgattt
     8221 tgtaagagat taacaaatat actctttttt tctgagaata atgacaaaaa ggttccctgt
     8281 tcaaccaatt tcccgtcatg cataactaaa atttgttccg cgttttggat ggtggacagc
     8341 ctatgggcaa ccacaatgac cgtaatgcgc tccttcaacc ggtgcaaagc ggtcagaatc
     8401 tttttttcat tctccgtatc cagtgcgctt gtcgcctcat ccaggacaag gatcgaaggc
     8461 tggcggatga tggctcttgc cagcaccagc cgctgccgtt cccctcctga cagacgaatg
     8521 ccccgatctc caatgagcgt ctccaattgg tgaggaagct tgcgtacaaa ttcagctgcc
     8581 gaggagaaat cgagcgcttc ccacagatcg ttctccgtgg cgctcggttt aaccatcaac
     8641 aggttttctc ttatgctcgc attatagaga aacggatcct gcgccacata cccgatggag
     8701 cgtctgtacg cgagcagatt ttcattcgtg atcgccatgc catccacgag gatttgaccg
     8761 gattcaggct gcatcaggcc cataaggagg tcgatcaacg tgctcttgcc ggcccctgat
     8821 ttgccaacga tagcggtcat cccttgggca ggaatatgaa cgctgatatt ttgcaaagca
     8881 tacacaggcc gctgcggctg ataacgaaac gaaagatttc tgacttcgat tccttgcata
     8941 acgaaccaag ggccaggtcc ctgagcgggc gattcggtaa gcgcgatcgc ctgatctgcg
     9001 gccaactggc agtcatgctg caattgctga agagccttga aggcggggat ggtcgaagcc
     9061 aattgttcca gcttggactg gaggctggta aatcgcggcc acaacctggc aaagaccaga
     9121 ataacgatca acaaagacgg tccctcagcc ggaaaaaagc gaaatgacac aaagataaat
     9181 ccggcaataa gcagtgagga cgatatttta tacaacagct gggaattcag ccttagccgc
     9241 acataatcca gctgctcttg catggttcct tcggtaagct gctggtgcca ctccaagcgg
     9301 gagggttcca ggttgttgct ctttatatct ttcattccct gaagctggtc agtgattccc
     9361 gccagataag cttgggcgag cttggacgta tggctgccga gctgcttgga tttgcgaata
     9421 aatccgcggg aaagaaaggc aagcatggct ccgcaggcaa tcacgaacag cgttatcgtc
     9481 ggtgagatcc agaaggcgaa aataatctga acgagggtaa acaaggcaga tgtaatgaat
     9541 tggaggagca gactgattcc ccccaagact ctggcggtct cgatcgtaag ggcattcacc
     9601 agatcggaag ttctgcggtg taggaaaaaa gaccattgcg ctcttagaag agcgctgtaa
     9661 ttctcgtaac gcagctgtcg gctgaaatgt tgctctatct cggcattgcg gatcgtaacg
     9721 gcccgatgaa tgaggttttg aatgacgaca atcagcaggt agaccgtgag aataatggct
     9781 agggaagaag cctgcggcaa gctgtgcagg atgttcaaaa actgcagcct gttctcccaa
     9841 gccggctctg acaacagaac gccgccaacc gtaagcatgg ggatgagcag aagaaatgtc
     9901 atgccttcca ggagactgct gatcaccatg ccaataatgt tgatgcttaa tcgtaaccct
     9961 gccgttttat gaagccgctt catgtaaagc gtaatcgagt tcataagtct gtccctgcgc
    10021 ttttcgcgaa tttctccacc acgacgaact gcttcatcat ctcggcgccg gtaatgtata
    10081 tcgagccgct gcggagccag gcgtgtgcga tcagttcgcc gtttttattt ttcccggtcc
    10141 ccaaatataa agtgctgttc aggtttcttt tctcaagcat tttcatgcct gctatcgctc
    10201 ttaccaagca tttgctctcc cagaacgtgt gccggctcgc gatatggatc gcgctccgaa
    10261 tatgcttcat ggtttttgta tccgacggat catggacttc cggcgtttcc atggatcgtc
    10321 tccccagcag cggcgagatc ttcgcgaacg gaaaatacaa aagaatgcgc gcccacccca
    10381 aataaagata agcttccgca aataaaagga atgtcttccg gtcgaacaag cataaccata
    10441 tccatcttct caaccggttc atagccgctt cacaagcctt atcaaccctt cacgttccaa
    10501 atccgagagg aacaggagaa tgtcttcctc gcattccggc ggctctacct catagtcgga
    10561 taaaatggat cgaataatat gttccgcctt cacgggcgtg acaagcatgt cccagatctc
    10621 gccgccaagc gtaccgagat tatagtattt tcccttctgg acgcttaaca tcactttttc
    10681 gccggccata tcgctaacga tatggccctc gcattgaaca agcgtatcga caggggcgat
    10741 cgaatgaagg ttgctcattg gtcattctct ccttgccggg ttatgtttaa gatgacagat
    10801 gtcagatcaa gcgcgctgaa tccaaccatg gggcggtgca gacggtacat cccgatctgg
    10861 tgaacgaagg atgtcagggt cttgaagtgc cattccatca atcccagcgg ctgcaccaac
    10921 aaattacggt acgtatggtg gaagaggact cgtaagcgat ccaacccctg gatcggcgca
    10981 ctatgagtcg ctgcatccca gggaaccaac tcaaagatgc ttgccaaagg aagaggttca
    11041 tcatgaaagt tggaccccgc gggcacggca aatttcgtat tacgctcata aagcggggtg
    11101 taactggcat tgtccattcc catgtgcttc aatgtgtccg cccataattt ttgctgagga
    11161 taagatggaa caacccaggg agagccttga gtcatcacga cgggaataac atcatcgcta
    11221 agcagcggat atccttcgga catcaggtgc aaggccaagg tggatttgcc cgccccggag
    11281 tcgccgataa tggcataggc cttcccgtca atagccacgg cgctgccgtg caaaggcata
    11341 attttgcgct gcagcaatag aatgcccatg caagtcccca gaataaaaag ccgaacccaa
    11401 tcctcttccg cctgatcgaa cggagagacc agaatggagg agccatcctg taccgcatat
    11461 atagctgccc caggtacccg aaacataacc gtacggccgt gatccagaat agccaagttg
    11521 ccataggaat gaatggtgct gttccagaga ggctgcaagt ctgtccgccg taccgtaatg
    11581 ttgtccatag gctcgcgctc gctagcctga ggcagttccg gtaatgcaaa gtcgctctca
    11641 atacggaagc caaaagcttt ataatggtca gtccttaccg ctgctcgttc ggtcatgctc
    11701 atctctccaa ggttttttaa atgagaacag gggaaccctt atacccgctg agaagtataa
    11761 gggtaccgca tcataaccgc attcattaag cctgttgtct agctatccat cggatcgtaa
    11821 tgcacgtctt catccgggtc cggctggaaa gcatccggcg tagaggtacc cggcccagcc
    11881 atggtctgat gaacatccaa cacttcaagg gacggcttgc tgtacggctt tttcatggtt
    11941 acacctcctt tccagagatt cttgacagga atttatggaa gatgaacccg cgcatcagca
    12001 cgcggaactt gagatcgaag gcaagctccg gccgcggata atcccggata tcgtccagca
    12061 gctcctgaag caggggggca ttcagataat aagaagttcg cggatcgcca atcatctgtt
    12121 caaactcccg gatcaatcca ctccactcgg gcatgagtct gaacacgccg taagcgccct
    12181 gcacgccgcg tctttttcga tttaatctca ccttgtcggg caggtagcgg gcggttgccc
    12241 tgcgtatgag cgaacggtcg acgccttgct gaacgaactg ttcatcaggt accgacagac
    12301 agaagcggac gacccgcaaa tcattggtgg gatccctgtc ccagatttta tgcttaaggg
    12361 aaagcttcgt gccgatcgtt ccgttaatat tccaaaagta cagttgatta aagtggtctt
    12421 tgcgaatgtc atacgcattc tgagtcgatg atccccagac gtccatgccg caggccttca
    12481 tgcagtccgt tacattggtt ttgctggcga actccgggtt aatcaagacc ggcagcgcag
    12541 ggtcgcttcc cggagcaatc agcggggcga gccaaggaaa gctctttttg ccgacgattt
    12601 gaagcacttt ccagggattc gccccaagcg attggcaata acgtctgtac tcccagaaga
    12661 acgagacgag acgtcctttc cttagcagac tggcctggta atccatggcg ggcccccagg
    12721 atatggtcca gttccccctc tgtccggtaa gcataatccc gatgccctgg gcagaggctt
    12781 gttcatagat tcccttaagc caaaaggagt tctcaaaaaa tttatacggc atctccagcg
    12841 tatcaagcca ttcgtcaatg acggagtaag ggttgcttgc cggataactg gatacattca
    12901 tctcgatatt gcctgcatgc tccgccgtgg accgtatgta ttctctttca tccgcaaaac
    12961 ggctgcctga agtgaaatcg gaaaagccct cgaccggata atagctgaag gtatagagag
    13021 gcttgttgat ggctctcaac atcggagcgg caaagctaac caccgaaccg gaatcaagtc
    13081 cgccgcttag gtgtgctccg acatggcggc atgttcttag acgggcatga acggcagtct
    13141 gaaaaacatc ccggaacgct tcctcatatt cctcgttgct tgcaagcaca agcttgtcac
    13201 tatgccgcag ccggcagtat tgttgaaaga ttactttccc gttggcaacg aaaatggaat
    13261 gggaaggggg aacctgctta atggattgat acacggtaga aaatgaatct acggcgtctg
    13321 tcgtgatcgg gatagcaagg aattgggaaa tccagcgttc gttcaagtct cttttcacgt
    13381 gcgggagctt tagaagcggt tccatgactg tgcagaatga gagcagttcc ggggattgat
    13441 gaaagtaaag ggtccgtgtt ccggaaaaat cccttgcgcc aaacatcgtg cgatccctgc
    13501 catcccaaat gatgaaagcg aaatccccta cgagatgttt gggcatatca tggccccatt
    13561 tcatatatgc ttggagaata agctggctgt ccgttatggt ctgaagagcc tgcttggata
    13621 gctgaagctg gtctgctaat tcgtcccgat tatcaatcat cgcatccgaa gtaatggcga
    13681 gcgatgtaac cggatcatag cagggcagga cctcgttgat ggattggggc gtaatgcact
    13741 gctggaggca tcccagaaag agggaaccgt tactccaact gcttatgtaa tcagcgggaa
    13801 agcgccgcaa ggcatcgatc atttctctcc caagtccggg ttccaactta tcgtgttgaa
    13861 ggtgataaag gcctgctatt gcacccatcg tcgttctcct ccggatacac atcctcgttc
    13921 ttgccgaaga acaatgaaac taaaatcgtt cttaataaag aactcgaata aagagtaaca
    13981 tccctcttta aggattgtca accctgggtc aaagaaaggg cgggactgca aaaatagaac
    14041 tggatgggaa cgtggacatt ctgacaacga gactccgcac caaatgctga gagagccggc
    14101 cggaatttgc cggttatgcc ttgacggtcc gtataattca actcatctgg cgtgccaaaa
    14161 tctgtcgcct tgtggttgat catgttcata tatgctttat aatgaaccta aacagttatg
    14221 cagcggaggt aatgatatgt tttcttacgt tttcgccttc cttctttctg cttgtatcgt
    14281 cctttttctg attcctccct tcaagaaatt ggcctttcgc atcggcttcg tcgatcagcc
    14341 gcaggcggat aatgaacgga aaatacatag gcagcccatt cccttgttgg caggggctgc
    14401 gatttttatc ggcttttgca tcacctatgt gtcgttcgtc ccgcattcct tgacgaagat
    14461 ggcaggcatt ctcggcgggg ggctgctcat cctgtccatc ggcatggtgg atgattggta
    14521 caagacccgg cgcaaggatt ttcctgcgct gccgaagctt atcgtgcagg taggggccgc
    14581 cgccttggtc tacgcttccg gtatcgcttt catcggcttc aacaacccgt tcacggggca
    14641 attcatctat ttgccggaat ggcttcagtt cctcctgacg gtaacctgga tattcggcgt
    14701 cacgacggtc attaactttt cggacgggat ggacggtctg gcagggggac tgaccgcgat
    14761 ctcggcgggg acgttgttca tcgtcggcat ctcgcacggg cagggaactc cggcgatgat
    14821 ggctttgatc ctggtcggag cggcaatagg gtatttgcgt tacaacaagc cgccggccaa
    14881 tgtctttatg ggcgacgccg gggcgacgtt tctcggcttc atgctggggg tggtggcgct
    14941 cgacggcgcg ttcaagcaag caacgctctt atcgcttttc attccgattc tcgcggtggg
    15001 cgtgccgata ttcgacaata ttttggtcgt cttccggcgg atgcttaacg ggcagccgat
    15061 ctacaaagcg gatgcgaccc aggcgcatta ccgtctgctg gcggtcggat tgaaccagaa
    15121 gcaggttgtc atcttcttgt gtttgctgaa tctttgcttc gggctgactt ccattatttt
    15181 atcgctgctg cccgtctgac gggtgaaatg cagcatgggt ggatgtaaca ccctctcaca
    15241 tcgtgcgaac aacgaataac ctctaaacca tatgaaatca ggtgaacgcg gatgacggaa
    15301 gaagaagcgc aggcccttgg gtgggacgcg attgatgcga aattgaagga agtgtacggg
    15361 gacacggagc cgcttcatta tggcaccgtc ttgccctata tgctgggcgg cgaggatccg
    15421 ctggacggga tcagcgtctt tgcgcaggcc gagccggagc cgcattggca ttatgtcaca
    15481 tacggcttct cggagttgta cgagaaggaa ggggacgacc cggagatcag cggctatggc
    15541 ttcgaactga cgatgcggct gaagcgggag ggggaagagg aacctccggc atggccgatg
    15601 aacatgctgc agaatctggc ccggtatgta ttccggtcag gcaatgtgtt cgcggcaggg
    15661 cattatttgg atgcgaacgg tccgatcgcg cttgactcgg atacggagat gagggcgctt
    15721 ttcttcatgc gggacagcca actgggcgag atggatacgc cgaacgggag cgtacaattc
    15781 ctgcaggtgg ccggcattac gctggacgag ctcgacatga tgcagtcatg gagaagcagc
    15841 ggcttcctgc caatgatgga ggaggttctg ccgctgggca tcaccgatct gaagcggacc
    15901 tcggtgcttc gcgatccgga taccgccgcc agagcggaag aggggatgcg gagggacggc
    15961 tccgggacag gcagcctgtt catcgatagt ctggcctggc aggaggagaa gaagttcatg
    16021 cggggggcgg tatatacgat tgagatcgga gcgaagcagg caccttcgat tgctcaaata
    16081 ctgcgcggcc gtatcccgta ccgggaggcg ctgtatttaa tcggcccgaa ccggcctatc
    16141 gcctgccttc ccggcgacga gcctcaggcc gtcgtgcagg acgacgctct cgagctgcat
    16201 ctgaacgagc aggcgctgga ggagctggct tcgcggctcg tgccgcgtca aggaacgttc
    16261 acgattgctt ccctgccgaa ggtgcaattt cacatcgtca agaccgagat ccggaaccaa
    16321 gacggcgaag tcgtcaagac gatcggttaa ctggaaggaa tatggcgctc atttgccctc
    16381 tgtcttctct gagaagatag gggctttttc atcaaaaaaa gggccgcgcc agcacgggga
    16441 actgcgtgta ctgtacgggc ccttcgaaga ggggcttggt taaaaagaag ttcactaagg
    16501 aaggggcggg accgttactg gcgaatgcgc tgctcgatct tgcccgtaat ctctttcttc
    16561 gccttcatgt actgttcgac cacttcatag agcgtgacgc cggtgtcaag cgattttttg
    16621 ttcatgaaca tggaatatcc gtctccgccc gcgatcagga agtcgttggt cgcgacatga
    16681 tacgttctgt cttcttccag cgccttgccg cccactttga cgtcggtcac gcggctgccc
    16741 ttcggctgct tcaagtcgaa gtcgaaggac atgcccgcaa tttgggggaa gcgcccggag
    16801 ccggactcga tttcgctgac tccgttttcg agagcggcct tcaggtcgct gcccttcact
    16861 tcaacgacag cgagcgtgtt cgggaacggc agcacgtcgt acaaattccg cttcgtcaca
    16921 tcacccttca taatggtcgt gcggatgccg cccgagttcg tgatggccag atcggcttcc
    16981 aagccgggca tcgtccgggt gcgctccagc atcgcgtccg cgaccagatt gcccatgatc
    17041 gtctcctgct tctgcactct cgatcggtcc ccgtccagat cgacgctcgc cgtcgcgatt
    17101 ttttcattca agagcgcatc ggtctctttt ttcagcgact cgacgatggc ggctacgtcc
    17161 gggtcgggct tcgtcgtttc gtcatatttg agcagtccgc cggagaaatg aaccaaatct
    17221 tcgccatgat agtacagatc gacccggccc agcgacttgg cgtattccca atcctgcacg
    17281 atgtaggtgc tattgaccag ctccggctca tcgaccgggg tatgggtgtg gccgccgacg
    17341 atgatgtcga tgcccggcac ctgcttcgcc atctcgcgat catactccag gccggtatgg
    17401 cagagcacga tgacatgatc ggccacttgg cggagcttcg gcacccattc cttcgcgacc
    17461 tcgatcgggt cccggaacgt caggcccttc acattgtcag gatgggtaac aatcggcgtg
    17521 tccttcgtga ccaagccgag gatggcgaag gtcttgccgc ccacctgctt tgtgacataa
    17581 ggctgaagca taggcttgcc ttccgcgtcg aagacgttgg cggccagcac agggaactcg
    17641 aacatcttcg tcagcctcgc aagctgctca tggccgaagt catattcgtg gttgcccgac
    17701 gccatgaagt cgtacccgag ggcattggcc agcttcgtcg ccgtttctcc tttggataga
    17761 ttcacgtaaa tggtgccttg aatcatatct ccggcatcca gcagcatcgt attcggattt
    17821 tcctcgcgca gatccttcat caaggtggcg agcttcgcgt agcccatttc tttcgctttg
    17881 gcatcttcga gaacgtggcc atgcagatcg ttcgtatgcc cgatggtgac atgcgtcgta
    17941 accgcgccgc cgagcgcctt gaagaactga tcgcgggtca ccgtgtctcc ggccagctcg
    18001 agacgcaacc ctgctctttc cgccacgctc tggagcgtcg ccgccggagc cggatgatgg
    18061 agctctttcc attgctccgc atcgacgatc ccctcctgct tcgcccacgt tagcgatgtg
    18121 gcggcccaat gcttgaacgc cggatcggcg gtcttcacgg actccgccgc gccctgcacg
    18181 cgcgcgagca tcgcgatcgc ttccacgagg gtgatcgggc gatccagcgc gagcccgtcc
    18241 ttggttccga atatgtagtt cttatcctgc atccattgga tgtgatcgat agggcggatt
    18301 ggcgccgcaa atagggagcc ggcgaacaag gcgcttatca gcgtcgtcag gaccgcggct
    18361 gtgccaagct tctttttgtt catacataac ctccgtcgca agaagaaatc gtgggaatca
    18421 agagagcttg atatgatata tatttaactt agggcaagcg aatgagggga ttgttaacgg
    18481 aagttatcgt ttttgtaaag gcgggtgtcg ggggatataa aaagcaaggc cgttccggtc
    18541 gcagatgaca ggacggcctt gccgcatacc gatgatattg tgggctggcc gcagggttgc
    18601 atgcgcgggc gggtgcccgg cagcacgcgg cttacagctc gtcgaagccg ttgtcgtcgc
    18661 cgaccttgcc gtaggtgcgc gatttcgctt cgaagaaatc ggtcttcgtc gaattgagcg
    18721 cctcgtcgga gaagggctta atccatggca tgcaattcac gtcgacgcct tcataggcct
    18781 tttccatgcc catcatggcg aggcggcggt tcgcgatata tttaatgtaa tcgctcagct
    18841 cgcgcagatc gatgccgcga atattgctaa gcgtgtaatg cgcccagttc gtctccagct
    18901 gaacggcccg gtcgatggtc tcgtagacga accggcggtt ctcgtcggta ttcagttccg
    18961 ggaagtcgcg cagcagctgc ttgaacactt cgccgaagaa gtagcagtgc tggttctcgt
    19021 cgcgctggat gtacgagatc atttggctcg tggccatcat cttctggtcg cgcgccaggt
    19081 tatagaagaa ggcgaacgtg ctgtagaaaa atacgccttc gagaatcaga tccgcgacga
    19141 gcgcttcgaa gaatgtctgc ggcgtcggat tgtcccggaa cgtctggtaa atgtccgcaa
    19201 tgaagcggtt gcgctccagg agcacggcat catgcttcca atattcgaaa atgtccttct
    19261 gctcctgctc cgacacgagc gaggacagca cataagaata agattgattg tgaaccactt
    19321 cctgctgggc gataatggcc gaaatggcct ccagggagga atcggtgaaa aaccgcttca
    19381 catcgcctac gaacatcgtc tgcatcgaat cgagcaccgc cagcagcgag atattaatct
    19441 tgaaggcgcg ctgctcgtcg ggcgtcagat tcggaaattg ctgggcatcc ttggacatcg
    19501 gaatctcatc ggcgatccaa tggttcagca gaagcacctt gtacagcttg tacatatgcg
    19561 gcattcggat atcgtcccag ttcagaatac cggagcattc gcccagaata atgcgggtcg
    19621 attgattcgg cgcctcggta ttgaatattt tttgcagttt cagttcgtga tcgagtaaag
    19681 tcatcatttt cttcctttcc tcacgttatc atcattctat ctgccgcagg gggaggaagc
    19741 cgttcccgaa gaagcgggat tgcttccgga gatgcgaagc cgcccccgga ggcgggcagt
    19801 cctgcattcg ctttacgagc tgcatgcttc gcattcctcg acggtcaacg cctggctgcg
    19861 cacgtaatag gtcgatttca agccggcctt ccaggcatgc agatgcaggt taaggaaatc
    19921 gacggcccgg atatcgggac ggacatacag gttgaagctc tggccctggt cgatatggcg
    19981 ctggcgggcg cccgccatgc ggatcgacca attttgatcg aggcggaatg ccgtcttgta
    20041 ataccacatc gtcttgtcgg ataagtccgg cgccggattg gcgattttgt acgtggtctt
    20101 ctcttcatag ctgagcagct cgtataccgg atcgatgctg gccgtcgagc cggcaatgat
    20161 cgaggtggag ccattcggcg cgaccgccat cagccaggcg ttgcgcatcc cgttcgcctt
    20221 gacctcggcc gcaagctcct tccactgatc ggtcgtcacg aagcggccgg ggcgcgttcc
    20281 ggtcgtatat tcgcgctgct cgaagtaacg gccgttctcc cattcggatt gggcgaacag
    20341 cggataagcg cctttttcct tcgccagctc catgctcgcc cgcaccgcca gataatgaat
    20401 ccgttcatag agatgatcgt tgtattccac ggcctcatcc gattcccagg cgatgccttc
    20461 cagcgcaagc agatgatgca ggccgaaggt accgaggccg atcgcgcgat agcgccggtt
    20521 cgtatgctgg gcttgcagca cctcgatatt gttgatgtcg atgacgttat cgagcatccg
    20581 cacctgaatc gggacgaggc gttcgagcac gccggcccgc acggcgcgcg ccagatgaat
    20641 cgagttcagg ttgcagacga cgaagtcgcc cggaatcttg ctgatgatga tgcgggcgcg
    20701 cccgtcttcc aggaccagct cttcctgttc gattgtggtc ggagacatgt tctgcataat
    20761 ctcggtacag agattggagc agtaaatggt gccatgcgcc ttgttcggat tggcccggtt
    20821 ggcggtatcc ttgtagaaca tataaggcgt tccggtctcc agctgagact tcaggatgcg
    20881 cttcatgatg tcgatggccg gcagcgtaat gcgcgacagc cgcgggttcg ccaccgcctc
    20941 ggcatacttc tcgcggaact gtccctgccc cgcctgttcg tcatagaaat cttccagtcc
    21001 gagcggccgt ccgttcccgt cggcccaccc catcgtcttc ttcacttcat gcgggcagaa
    21061 cagatgccag tcttcgcgct tctcgaccgc ctccatgaac agatccggaa tgcagacgcc
    21121 atggaaaata tcatgcgcgc gcatgcgctc gtcgccgtta tttaatttga gatcgaggaa
    21181 ggacagaatg tccttatgga acacgtccag atagacggca atggcgcctt tgcgcgtgcc
    21241 gagctggtcg acgctcacgg cggtattgtt cagctggcga atccagggga tgacgccgga
    21301 gctcgtattt ttgtggccgc gaatgtcgga gccgcgcgcc cgcaccttgc cgagatagac
    21361 gccgatgccg ccgcccatct tgctcagccg ggccacatcg gtattcgaat cgaagatgcc
    21421 ttccagcgag tcgtccaccg tatcgatgaa gcagctcgac agctgtccgg cgaccttctt
    21481 gcccgcgttc gccatcgtcg gcgtcgcggc ggtcatatag agattgctca tcgcccaata
    21541 ggcttccttg gccagctcga cccggcgctc ctccggttct tgatgcatca ggtacatggc
    21601 gatgatcata tagcgctcct gcggcagctc catcgtgcgc ccttcgaaat caaccgccaa
    21661 ataccgttcc gcgagggtca gcagcccgat atagtcgaac agctcgtcgc aggccggaac
    21721 gatggcctgg cccagctccc gaatctgatc gggcgtgtag gcctccagca gctcctggcg
    21781 gtaaatgccg atatcggcca actgcttaac cagcttgtag aagtcgccgt acggacggtc
    21841 ggcatatgcc ttgtagctgc ggtgcagggc cgcttcctta tacagcttcg tcagcagggc
    21901 gcgagccgcg acgaacttcc attgcggttc ctcgacggat accagctcca atgcggtcat
    21961 gatgcaagcc tgcgtgatgt cggatgcctg aacctggctg tgacggagct tggccaggac
    22021 gccccggtgc cagcgttcgc gatccagcct cgggtattcg cccatgatgc gctcgccgta
    22081 acgcaggatg cgctccgcgt cgaacgcgag cgagcgatta ttcggtttgt gtacggtctg
    22141 aacggtatga ttggtggtta gcatccgtat tcctcctcga acagaacaat aaaaatagcc
    22201 gttccttcgc gagaacagct caggaacggc atggcaaagc cgtatgtatc cgggggcttc
    22261 ttatgatggc ggctgcgcat caacaggaca aggcgcagct cccccgcaac cacgcagctg
    22321 cgttcgccgc cgaaggcggt acgcatcgca gcgcggcctg aacacgttcc ctattccgcg
    22381 tagggacatc aatgtgctgc gatacaggca ggtctcctgg ctcgaagccg aatacctcgg
    22441 cggccttccc gggacattcg tcccagtgga catagaaaag gcggctctct atagagcgcc
    22501 tgttctgccg ggtacttgcc ccggaacgga gatgatcgat gttccggaag cgcttctaac
    22561 agtggcggga ccgcgacgga ttcgcaccgt cttccctatt aagccggggc ccgacgcgca
    22621 tcgctttgtc gaaccgcagc acctgtatcg ttcaatatgt tgttgtactt atgccaatat
    22681 actacaacat attggggatg taaataggtt agaggtgata ttcctcatag gaaaacgaca
    22741 ggatttgaga cagctccgcg tgctgttttt ctgcctcaga gcagaggaga tgagaagctg
    22801 cgagacatat ttcgggaaat ttgaaggagg cagggatgga cgttacaata agcgcctgaa
    22861 ccgcattgaa gagcatctgc agcgcaccac cgacttcaag cggatgcctt gactgcaagg
    22921 attggcttct gcacctcgcc cccgttcatg acggcgattg tcgtcaggct gcttgtttgt
    22981 agcgcacagc ggcattgggg cgaagacagc ataagaaggc ggagccgctg atgcggcccc
    23041 gcctataata tctcgtgttc atgatgcaat gattctcatc aatagattac cagccgcgct
    23101 cgtattgctt cggcggagcg agctcctggc gcaattgctt cgcggccaga cgcggccagt
    23161 acggatcccg cagcagctcg cggccgagga agacgagatc ggcccgggcg ttgcgcacaa
    23221 tctcttcggc caaggcgggt tcggcaatca gcccgacggc cccggtggcg atgccggcag
    23281 attgacggat cgcgtgcgca tattggacct ggtaccccgg atacgattcg accgggtgag
    23341 ggacgacccc gcccgagctg cagtcgatca ggtcgacgct ctgatccttc atgcgccgcg
    23401 catagtcaat atatgcctcg atctcgttcc cgccttcggc atattcattg gccgagatgc
    23461 gaacgaacag cggcttggac catgtgagac gcaccgcctc aatcacttcg ctcaagaagc
    23521 ggtagcgggc gtcggcgctg ccgccgtagc tgtcggtccg ccggttcgtc agcggggaca
    23581 ggaactggtt gatcaaatac ccgtgcgcgc cgtgaatctc gatcacgtcg aacccggctt
    23641 cctctgcccg ccgcgcggcg tcggcgaatg ccttgatcgt cttgcggatg tcctccagca
    23701 tcatctcctc cggcgtctca taggcctcgc tgaagcgcag cgccgaaggg gcgataattc
    23761 cgggaacggt tgctttgcgc ccggcgtggg ccaactgaat accgatcttg ctgccgtgcg
    23821 catgcaccat gtcggtcagg cggcgaaggc cttcaacgtg ctcatcgctc caaatgccca
    23881 gatccttg
//
