LOCUS       NZ_CP089312            25254 bp    DNA     linear   CON 28-JAN-2024
DEFINITION  Streptomyces sp. GQFP chromosome.
ACCESSION   NZ_CP089312
VERSION     NZ_CP089312.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. GQFP
  ORGANISM  Streptomyces sp. GQFP
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8306813)
  AUTHORS   Zhu,J.
  TITLE     Complete Genome Sequence of Streptomyces lacrimifluminis strain
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8306813)
  AUTHORS   Zhu,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-DEC-2021) School of Life Sciences and Biotechnology,
            Shanghai Jiao Tong University, Dongchuan Road No.800, Shanghai
            200240, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 4; canu v. 1.6
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 109.0x
            Sequencing Technology             :: Illumina HiSeq; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/28/2024 04:27:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,499
            CDSs (total)                      :: 7,422
            Genes (coding)                    :: 7,228
            CDSs (with protein)               :: 7,228
            Genes (RNA)                       :: 77
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 62
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 194
            CDSs (without protein)            :: 194
            Pseudo Genes (ambiguous residues) :: 0 of 194
            Pseudo Genes (frameshifted)       :: 69 of 194
            Pseudo Genes (incomplete)         :: 156 of 194
            Pseudo Genes (internal stop)      :: 7 of 194
            Pseudo Genes (multiple problems)  :: 35 of 194
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:04:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7342310
            Orig. end                         :: 7367564
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP089312.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25254
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="22"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25254
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25254
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15254](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15254)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    92..107
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.74"
                     /tool="antismash"
     gene            complement(240..440)
                     /locus_tag="LUX31_RS33270"
                     /old_locus_tag="LUX31_33270"
     CDS             complement(240..440)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LUX31_RS33270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LUX31_33270"
                     /product="hypothetical protein"
                     /protein_id="WP_235479013.1"
                     /transl_table=11
                     /translation="MTIRTGTSPAGEHPAPEESMRGEEPRFVIPGDRRILAAQRAAGRV
                     MAHRRSQLIRRSVRRPIQALV"
     gene            complement(620..1591)
                     /locus_tag="LUX31_RS33275"
                     /old_locus_tag="LUX31_33275"
     CDS             complement(620..1591)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006378728.1"
                     /locus_tag="LUX31_RS33275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_33275"
                     /product="phosphotransferase"
                     /protein_id="WP_235479014.1"
                     /transl_table=11
                     /translation="MQITKLSRKGANRHVVTDEGKRLFVKEYHSTTGRDPARVALDTSQ
                     HCRAAGLPVPLVRPDKDNCLMTVARGSAWSVTDEAPGRVSTSAMTRPLAEHTGTVLGRM
                     HRVLTAYPPPEHVQPSPWRTEPTENAHAQCATVLSNAVRHQWTHDGQLHADLDQRRDDL
                     DRHVLRLRRQLPDALVEQALHADAGRTSQLVLADQVTGIIGFRGARGATAWELARVAFD
                     PRTVSTSPDWIACALTLLDAYHLANPALPLPDLQACARIALLDLLFDFEGAPTAAYNQC
                     ELEQAIQQREWSERQTTIRRLLEHLDDLDDALDEFGAETGGP"
     misc_feature    complement(827..829)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(1070..1072)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(1659..2546)
                     /locus_tag="LUX31_RS33280"
                     /old_locus_tag="LUX31_33280"
     CDS             complement(1659..2546)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LUX31_RS33280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LUX31_33280"
                     /product="hypothetical protein"
                     /protein_id="WP_235479015.1"
                     /transl_table=11
                     /translation="MTVRRITIVTCDFEPSGNGDHSMWSAIHRQPAVLHPAMRCRQENV
                     GHARTGRRSTLFGESKHIRRRPRSIERISPVSTRLARPPATLLPLTPLQLRIVRKIAYG
                     AATTAIASELSLTIGSVNVQVTLCGRKLGASGRAAVVHATFATHQLPCPERAAAPGEFS
                     DQHIEAWRMLAIGAPSRVYAQRVRTSRGEALRRVTALRKFVGAVNAPHLVTLGWAHGQL
                     DDSLTKMATGHLLCTPVHAGAGRRQGRGVPSAEHVTRTPPPRQHQHVAIGPDQTAGAPY
                     RLVPVRTGTGELDG"
     misc_feature    2570..2585
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.58"
                     /tool="antismash"
     gene            complement(2695..3891)
                     /locus_tag="LUX31_RS33285"
                     /old_locus_tag="LUX31_33285"
     CDS             complement(2695..3891)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006378910.1"
                     /locus_tag="LUX31_RS33285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_33285"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_235479016.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.7e-19, bitscore:
                     69.3, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 6.2e-16, bitscore:
                     57.2, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 3.4e-26, bitscore:
                     91.0, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPATSPYLTDDHHSLREQVKSIADTEIAPRVPDMESRGPHTDREL
                     RPILGQWLGLLIGSEWGGKDAGHLAKTVAVTEVSRVSGAAGAILQASILGSAPVIEYGS
                     AEMRRRWLPAIADGSVWPSIAVTEARHGSHLLDMDTTARLDGGDLVIDGAKEFIGNADL
                     ADIHCVVVRTGERGTKRGLTAVLVEADRNGVDIVRQPASGLYGFSVDRLRLDGVRVPEA
                     NIIGEVGDGQDVALMASVVYGRLNLAAVALGIHQQALDVTITWVSEERERYNGHLADVK
                     MVRRRLAKMSFRLMQAELAAYHAAYLLDHGEPCDRWLYNAKLVNNRHGVASAEDAKQLH
                     GGHATRIGNPCERILRDIQLINAPAGPDDIQLKYIADDLLSPARHQWSAQHASRRRAA"
     gene            complement(3958..4494)
                     /locus_tag="LUX31_RS33290"
                     /old_locus_tag="LUX31_33290"
     CDS             complement(3958..4494)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017944162.1"
                     /locus_tag="LUX31_RS33290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_33290"
                     /product="GAF domain-containing protein"
                     /protein_id="WP_235479017.1"
                     /transl_table=11
                     /translation="MNPHAPSGLLTATGHDVDWQSQLPDHFDPAAPPVGAFDAFAQQVA
                     RAAGTPYAMLNWVGSEQFFIGLANPTGGELPVVGRSMPLTHGFCPHVVQRRGSLVLTDV
                     LDYDDFAGNPVVDEIGVRVYIGAPLIDERTNHVLGTICGVGTEPRQRSEGRALWNTIDH
                     QRDLFMADFYRRTSA"
     gene            complement(4491..5120)
                     /locus_tag="LUX31_RS33295"
                     /old_locus_tag="LUX31_33295"
     CDS             complement(4491..5120)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006379151.1"
                     /locus_tag="LUX31_RS33295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_33295"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_235479018.1"
                     /transl_table=11
                     /translation="MHSTRSDPGLSRLFAGATPTSTKIVVAGGFGVGKTTFVGAVSEIT
                     PLRTEAVITTASEGVDDLTLLFDKTATTVGMDFGRITLPQLNTILMLFGTPGQTRFWFM
                     WDELTRGALAAVVLVDTRRLDESFPAVDYFERLGLPFLVAVNVFDDASHYDPAEVSAAL
                     ALAATVPVVLCDARKRADAAYVLGRLVDHVLNLSDVSAHLLQGAPL"
     gene            complement(5101..5481)
                     /locus_tag="LUX31_RS33300"
                     /old_locus_tag="LUX31_33300"
     CDS             complement(5101..5481)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017170.4"
                     /locus_tag="LUX31_RS33300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_33300"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_235479019.1"
                     /transl_table=11
                     /translation="MTASEMAATGGPAWTVEDTEAPSHYVLTGGQTRPTHDLQIQTLLW
                     AEGEPPPGQPREAEQAVALCRGRPLAVAEIGALIGLPFQITRILMSRLIDIGALNTMSA
                     TDSAALPDVALLKALRDALHTL"
     gene            complement(5468..5950)
                     /locus_tag="LUX31_RS33305"
                     /old_locus_tag="LUX31_33305"
     CDS             complement(5468..5950)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015232.4"
                     /locus_tag="LUX31_RS33305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_33305"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_235479020.1"
                     /transl_table=11
                     /translation="MTTDSTAVQPEEVLVLDQALKDLAGLPEVNGALLASQDGLRLAHA
                     GPAMDGTLADRLAAVINGMYSIAHGIDDGKGAVEQVLIRKSSWLLFIMSAGYPPAAVAV
                     NAGRDPAKVQSVLGVLTTTKADEGAVGFAMVDLINRMGELLATPARAGGDSSGDGQ"
     gene            complement(6041..7720)
                     /locus_tag="LUX31_RS33310"
                     /old_locus_tag="LUX31_33310"
     CDS             complement(6041..7720)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="LUX31_RS33310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_33310"
                     /product="ATP-binding protein"
                     /protein_id="WP_235479021.1"
                     /transl_table=11
                     /translation="MSDLSCPRPHGHRRGQRRRARDAEPLRTERGLRLRLRLLVLVPAL
                     LVSAILCTAAAVSTTVRVPGDGWIIAAVVAATGLAVLMCADWLAVRMAAALHQQRSEDS
                     DSVHGWLRHFQSGVNEGRKSISDALEQINRGERPSPPDFGTPQGNSDSNPWSETEAALL
                     RLHAEAWRAVANGRQTELTQALVYLAGGMTLLLVRALGTVSELTKQVQDPDVLYSVFEV
                     NNLLKRMRRSAGRLAVLGGVKARQLNQPTGLVDLLRGAAGEIEKYRRVRMHTSTLDVQI
                     PGFAAPDLIHLLAELEENATLCSPPDSQVIVRATRVTAGLAVEIEDRGIGMAEGEIDRR
                     NRMLADPQDSDLAEQLALRQTGLLVVAKLARRYGIQVKLQKNLMHGTTALVVVPNKLLL
                     WRDKPAAPSGAQPGAHGGAAPGPAAQFAARPVLQPAGGPRPSPPAQVPVAAQVPAGMAA
                     LPSRAGRRAPAQQPLAVAAAAAMSSEGAPHDARPRLPQRTPQATVREPEASAVPDAAPA
                     PTVPPDPAFVSNFAQGVLRAEQAHGAGLPNRPAARPSDGSAG"
     gene            complement(7928..8122)
                     /locus_tag="LUX31_RS33315"
                     /old_locus_tag="LUX31_33315"
     CDS             complement(7928..8122)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006379283.1"
                     /locus_tag="LUX31_RS33315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_33315"
                     /product="hypothetical protein"
                     /protein_id="WP_235479022.1"
                     /transl_table=11
                     /translation="MSITLSLVLVLAVVVWLLISKGGLKASHAAAAVLLGFHLHDISLA
                     PSISSVVASVAETVSRVRI"
     misc_feature    8378..8393
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.61"
                     /tool="antismash"
     misc_feature    8379..8392
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.38"
                     /tool="antismash"
     misc_feature    complement(8429..8444)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 21.99"
                     /tool="antismash"
     misc_feature    complement(8498..8511)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     gene            complement(8554..8679)
                     /locus_tag="LUX31_RS37585"
     CDS             complement(8554..8679)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LUX31_RS37585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_268828233.1"
                     /transl_table=11
                     /translation="MPEPTFRMAVGAARNRLTASESRFVMDKPDSRLVVDWPLRS"
     gene            complement(8829..10004)
                     /locus_tag="LUX31_RS33320"
                     /old_locus_tag="LUX31_33320"
     CDS             complement(8829..10004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006379191.1"
                     /locus_tag="LUX31_RS33320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_33320"
                     /product="hypothetical protein"
                     /protein_id="WP_235479023.1"
                     /transl_table=11
                     /translation="MTAPPQPPLERLRRLSGRFPLVSRSHLVYRNFAARIDEVRTCGEK
                     SAQDGPLLDRINLACATWNLSALIASDCGLTDLATDLCLRQLRLFQAAWPVTGDTAIAS
                     LQPIVNLVRLTARTGDPQAAHQQLMSVHRAAHDGGTVTVHGQSIGLTGFTTEATLNHIR
                     PWLHDLLLDDGTRLLVAAGQWRQAAEHATVYDKEPERLYGSRQAHVVASLHTDAQDTAN
                     SLIDKATITEPWEEAVAQILRHYADHLAGRATAKGFAATAIAVRDALEPDPPHLRMFRV
                     RLVLAAIDLAPEGCEVLARPLYDAIVSDTTQARDAYAAREILRHPAPPAGGWSRRELEA
                     IVHDGCLGRGSLPESVLSTMLRAVGTAGASLAQCLTEGGGVSPHARRPGVS"
     gene            complement(10001..11005)
                     /locus_tag="LUX31_RS33325"
                     /old_locus_tag="LUX31_33325"
     CDS             complement(10001..11005)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006379081.1"
                     /locus_tag="LUX31_RS33325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_33325"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_235479024.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.5e-39, bitscore:
                     134.4, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTDRLNQPSLLDATLHAVLDVLAGTDMNTAAARAGLEPADLDAA
                     VAVYQQAGQQALAQQAGPPAWRQLYIQFTDWDKAEQTASDHLVPVLDLAQQDGLITGWW
                     FIRKHPCWRMRLLPAVGTQQLPLALAGLLDELTAAGHIHRWWPGIYEPETAAFGGDISM
                     TIAHTLFHADSHAILTTGHGELGRRELSLLLCATLMRAAGLEWYEQGDVWHRVTRERPL
                     PSDVPAAKVHAMADSLRQLLLADTSPAGPMLQSDRALKPAADWVSAFRQAGRDLGTAAR
                     DGVLDRGLREVLSYHVIFHWNRLGLPARTQSVLAHAAHTAILHPVDPTERPMP"
     gene            complement(10987..12210)
                     /locus_tag="LUX31_RS33330"
                     /old_locus_tag="LUX31_33330"
     CDS             complement(10987..12210)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006379019.1"
                     /locus_tag="LUX31_RS33330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_33330"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_235479025.1"
                     /sec_met_domain="LANC_like (E-value: 1.8e-41, bitscore:
                     140.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTATNPAVLADTYARHLATPLPPPEEQPWAAQDLAAGAAGSALL
                     HIERARTGDGTWQQAHPWIKTAVATPVSAADTSGLYLGAPAAAFMLNCAVTAEAPRYQN
                     ALAVLDHHVAQLAHRRCDAAQTRIRHGRPAGFHEYDIFYGLTGIGAYLLRRSPSGTAMA
                     RVLAYLVQLTRPIRHDDLGGLPGWWVDHQPDLTPSTVPAGHANFGAAHGIGGPLLLLAR
                     ALRQGVRIDGQEDAVDTILHWLDTWRQDGPAGSWWPEHLHLGELRAGRPVQRGPGRPSW
                     CYGTPGIARAGQLAALARRDTARQHLYEDALVHCLTDPDQLSKITDAGLCHGWAGVYQT
                     TFRAARDAAGPALRAALPDLAAALTQHARPGGDPGLLQGDAGTALALNTAAHDAAPTSG
                     WDACLLIG"
     gene            complement(12207..15254)
                     /locus_tag="LUX31_RS33335"
                     /old_locus_tag="LUX31_33335"
     CDS             complement(12207..15254)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006378945.1"
                     /locus_tag="LUX31_RS33335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_33335"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_235479026.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 8.8e-205,
                     bitscore: 680.3, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 5.5e-18,
                     bitscore: 64.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.7e-11, bitscore:
                     42.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAHGIPLTYQWQPGMLLRASTASQPIPVPDFDLHGDDAAIRGRRW
                     LDEVWRAPVPTALSAASPVLCQRVAEILNGAVTDDRRIRRAVRSVAAYLLRWNHRPTPF
                     GVFAGVAPAEPAQAARILWGEGYRTVLRPDSDWLTDVITRLESHPALVARLTVVANNTG
                     RPRGNRHVVDGMPADAHTSGYAPVELSVRLTRPVAAVLEAARTPVPYELLVHRLSGQFP
                     TARPEQLAGLIGDLLSKHVLISSLWPPMTSVDTLAHICDELEKADATGIPDIAELASHL
                     ASIRGGLNHPDTVAPWTLGDPLTQSMQYVSATGRVPLLVDAALDCTAHIPEALLAEAAE
                     AAQVMHQLSPHPYGYPQWRDYHQRFLDRYGNEALVPVLDLVADSGLGLPAGFLGSERAR
                     PPYEVTDRDEKILRLLQEAMLDGRRELVLTRATIADLTAHHTEPLLPVPRAELAVEIHA
                     PTLEAVQCGDYRLLVTGAPRPGSSMLGRFAHLLPPSAQSALTDSYATAGPGAIAAQLSF
                     APRRRRNENITRTVQVLPFTIPLGQHHEPGPGVIPLDDLAVTADTRRFHLVRRSTGQHV
                     EPRVTHALEASVHTPPLARFLAEITTARSAAYRAFTFGVAATLPYLPRVRYKRTILTPA
                     RWLLSAEELPGRSAPMADWDKALARWRERLCVPDRLALVEDGQQLPLDLDQRIHRALLR
                     AGADRNRVVELRESTTAQDWAWIGRPHELLIPLTNSTPADPPRLTEPAAATGTPSQPTV
                     LYARLFAHPQRYDEILTGHLPTLLDQFATMPLWWFRRHRDTTRPASDQHLDLYLRLPDP
                     AAFGAAAQQVTGWADALGSQRLAGHLELTTHPPKSGPYGHGPALDAAHLVFAADSAAGV
                     AQIRAAADDAAIGQALTAASMFDLTVRFTGDADQASDWLTRALPQERGPLARERVTLAL
                     ALADPEHTALQALPGGPAVIAAWRQRAAALTAYRQQLSTARNADNVLLSLLHEHCVRAL
                     PVDPEHERATGRLARACALRHRERQP"
     aSDomain        complement(14508..14789)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_LUX31_RS33335_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.10E-20"
                     /identifier="RREFam001.1"
                     /label="LUX31_RS33335"
                     /locus_tag="LUX31_RS33335"
                     /protein_end="249"
                     /protein_start="155"
                     /score="64.2"
                     /tool="antismash"
                     /translation="TVVANNTGRPRGNRHVVDGMPADAHTSGYAPVELSVRLTRPVAAV
                     LEAARTPVPYELLVHRLSGQFPTARPEQLAGLIGDLLSKHVLISSLWPP"
     gene            complement(15342..15548)
                     /locus_tag="LUX31_RS33340"
                     /old_locus_tag="LUX31_33340"
     CDS             complement(15342..15548)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006379227.1"
                     /locus_tag="LUX31_RS33340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_33340"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_235479027.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 2e-15, bitscore:
                     55.2, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTAVLHSVPAPLGLPVDALADDDFELDIRVVISESPLTVFMCPT
                     SDGCGNTCVNGASACQSSIEDAA"
     gene            complement(15607..16830)
                     /gene="fxlM"
                     /locus_tag="LUX31_RS33345"
                     /old_locus_tag="LUX31_33345"
     CDS             complement(15607..16830)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006378734.1"
                     /locus_tag="LUX31_RS33345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_33345"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_235479028.1"
                     /sec_met_domain="PCMT (E-value: 1.1e-37, bitscore: 128.6,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDVTMAPDEATQLRNKVVDQLKEDRTIVSPAVEAAMRKVPRHLA
                     VPEAPLENAYSTYNAVITQEDEHGNHTSSVSAPQIQAMQLEQAGIRPGDNVLEIGTNGP
                     NAAYLAELVGPTGQVTTVDIDPAPADRAQRFLTETGYTGVNVVVADAENGLPEHAPYDA
                     IVVTVGAWDIPPAWIDQLKDDGRLVVPLRINGLTRTYGFVRRADHLVATSAHVCGFVAA
                     QGAGSHAQQVMQFPGEEGVTLRFDEGLPANPSLLDGVLNSARAETWTGVTVASQEPIGT
                     LQMYLSTRVPTYCFMSTDPELAAGRIGPTGSGWSMVAIDGPHFAYTVVRRDSEKKTAEY
                     GVHAFGPDAAEFAERIADILRTWGAKVRGTDGPRIAVYPAGTPDDRITGDRIIDKRHSR
                     ISISWPAV"
     gene            complement(16934..17185)
                     /locus_tag="LUX31_RS33350"
                     /old_locus_tag="LUX31_33350"
     CDS             complement(16934..17185)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LUX31_RS33350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LUX31_33350"
                     /product="hypothetical protein"
                     /protein_id="WP_235479029.1"
                     /transl_table=11
                     /translation="MTPALFRFGTYYRLNPRLPTTPAQNQCSELTVGMIRAAGLSRLRP
                     AHHHVVAHIEFVWLVTETHQTGRHTSTFERIQELPLRH"
     gene            complement(17182..18432)
                     /locus_tag="LUX31_RS33355"
                     /old_locus_tag="LUX31_33355"
     CDS             complement(17182..18432)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006378648.1"
                     /locus_tag="LUX31_RS33355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_33355"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_235479030.1"
                     /sec_met_domain="PCMT (E-value: 0.00011, bitscore: 20.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTPDSVTPEQVNEDGWLEYGQRQLDRGYRPPEVTEIDWGFWGTG
                     PGTTVLGNIAGHRVLDIGSGAGVHAAHLARAHSAFIDAIDISATQQQRARHRFTYLPGV
                     RFLLGDAVAHLRDTEPYDLVYSVHGLSYIDPCRLLPMLRDGIRPGGRLVFSTLHTNLDG
                     LGPSSTVASRQEEIRLAQTPPIPVQMWILAPDVWERLLAENGFAVESIELLHAPDTDNP
                     VVVQLIQARRLIHPDTPRVVTQERSQWSPLPQAALGVGVIVTNPDGHVLMGQHRLGTHE
                     LPGGKVDASASAVESIEGAAMRELAEETGLVADPKDVRVLALLLDARHDIKRLTAAVVI
                     RRFDGTPTTRKPKTVAEWRWHPLDSLPSPLFVPSAQVLRCWRPDLPIDHPPAHRYPVDS
                     SRPPRPRTHGDARRSPP"
     misc_feature    complement(17587..17589)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(18429..19835)
                     /locus_tag="LUX31_RS33360"
                     /old_locus_tag="LUX31_33360"
     CDS             complement(18429..19835)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006378594.1"
                     /locus_tag="LUX31_RS33360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_33360"
                     /product="phosphotransferase"
                     /protein_id="WP_235479031.1"
                     /sec_met_domain="APH (E-value: 1.3e-17, bitscore: 63.3,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNGQVASHRGGDDIVQRHREPVDVHLILRRSGEVLLSRRAGDTYA
                     SGLLHMPSGHLDGDFEDVVTGLIREAEEELGVLIRPENVRFALVMQHRSPGGENRTGWF
                     FEVTQWFGHPRIAEPDRCSQLGWFPLNEPPVDMVAYCRAGLDAYRHGHTAALHLQEPGD
                     PIAYDPAGPSRLYPLPSRAPDARAMLGEQLSDFAEQAIGPLHTVTDSSWAREGSRVWKL
                     TGRSGGSWFLKVHQNTTFHEREVAAYRRWVPALGRGHAPQLVAADPDQFAAVVTAHAGI
                     NLHGADLNEPTWQAVYRQLGQLLRVLHSCEPAMMAPAVGGLAKLDRHLAAADGLLEPGE
                     EKLIRRLAQRLTTLPPIPHGPRHGDIQLRNLLLDDSMLLALIDFERAEVGPLVSDFIRI
                     ADTWANAPARQAAIFDGYARSLSPDEARALQGLSALDALSGIQYGAAHGDPELVERGHR
                     TLYRLRKDAA"
     gene            complement(20094..20936)
                     /locus_tag="LUX31_RS33365"
                     /old_locus_tag="LUX31_33365"
     CDS             complement(20094..20936)
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006378920.1"
                     /locus_tag="LUX31_RS33365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_33365"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_235479032.1"
                     /transl_table=11
                     /translation="MRPDHPMLLHPSGAIAELQARPSSARMQNYLLGGRDHYIVDREGA
                     LRAADRMPFLESAVRHERMYVLLMVQALAIAGVRQLVDFGCGLPHGPTPVDVLTRVHPD
                     ARAMCIDNDVLVHTHAEEMMTAKAPAVVESLCADVRDPESILASREILETINWREPVIL
                     LLGSVLHYIKDTAAQPLTVLVDQYKHVAATGSALVITHATADVSGKPVRRFAKTMTAAG
                     CPVHLRTKEQIARLFDGWQLTSPGLTAPQALALDYPVLPQAASYAGTARKEAAHGRAV"
     gene            complement(20926..22092)
                     /locus_tag="LUX31_RS33370"
                     /old_locus_tag="LUX31_33370"
     CDS             complement(20926..22092)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006379032.1"
                     /locus_tag="LUX31_RS33370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_33370"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_235479033.1"
                     /sec_met_domain="PCMT (E-value: 3.1e-10, bitscore: 38.9,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNARVEASSLRPGRAHVHEHAGDVFTCDRRQDFVPNVIRTHRGGR
                     WRRVDRSKNAGEWAKFVHRSEMLVFDVDDGGEGGPGIVTGVIPSKEDATARLAALAPEP
                     GMTVAEVGTDCGWTAASLEHLLQGGQVVTVADTERLAEIARQRLRPYPRVRVVNGSEAG
                     VMGPAGSFHGLLSHRAVRHVPWEWVTRIRPGGRLCLPVRTALGGSSTLLVLTVARDGAS
                     ASGRFHAGPAHQTVWLREHRPGEGISVESQGSPRASEADARGAHVRLAARLFAGLLRPD
                     LRMQVVRGVAQFEGDVADRLRIHDHQASRAVVFLHSPRVYEWGPRDLGSDLFDALGQWH
                     AAGEPEVEQLGVTITEMEHTLWLGAPDGPSWRLPELHTITGGVERHAP"
     gene            complement(22089..22580)
                     /locus_tag="LUX31_RS33375"
                     /old_locus_tag="LUX31_33375"
     CDS             complement(22089..22580)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006379047.1"
                     /locus_tag="LUX31_RS33375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_33375"
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_235479034.1"
                     /transl_table=11
                     /translation="MPAPDETISPPLSSQEREALLGISQGRTTAETACDMGVSDSTVKT
                     YILRIGGKLRTSERAGMVDLAYRHGHLDVPMLVAYDVELPKEQRTVLAGLAGGKTVEEI
                     AVDAKRVLDDVRKDARRLLRALGASSAAHAVTRGWQFRLLGPASGRENSGDVVSVAGQA
                     "
     misc_feature    22886..22896
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            complement(22893..23672)
                     /locus_tag="LUX31_RS33380"
                     /old_locus_tag="LUX31_33380"
     CDS             complement(22893..23672)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006378931.1"
                     /locus_tag="LUX31_RS33380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_33380"
                     /product="DUF6415 family natural product biosynthesis
                     protein"
                     /protein_id="WP_235479035.1"
                     /transl_table=11
                     /translation="MSWPEGSFRELGRDLRTAVSTLAPGPSPLAVQEALHREVTRLVFA
                     EAASVSEDPDERHVQLLLMRGHLMRLLGAIVPVDANEPPLEDDRLVVRVRGLLDEEIPG
                     DAGRAAFLHRRMSEVGRELLAVLPAVDAFDDVVDGWDRAVCAGFDSTRIREAIRAAKSW
                     EQAGVYPHPPTLAAVTRALGGYVTTLVPYVSIHLESLASGSRGWAACGEVIERSQEARD
                     VPPGEGLRAAREHAFRLAVHTEALLRYAEQDCERDGE"
     gene            complement(24137..24346)
                     /locus_tag="LUX31_RS33385"
                     /old_locus_tag="LUX31_33385"
     CDS             complement(24137..24346)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LUX31_RS33385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LUX31_33385"
                     /product="ATP-binding protein"
                     /protein_id="WP_235479036.1"
                     /transl_table=11
                     /translation="MGLRIQYPDGELRIEVTDDNPTPATLRPADDEDLSGRGLFLIAVL
                     SREWGVSDDGRTTWCVFRVPARRS"
     misc_feature    complement(24439..24455)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.53"
                     /tool="antismash"
     misc_feature    complement(24875..24890)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.5"
                     /tool="antismash"
ORIGIN
        1 gttcgcgggt gtcgggcgct gaatgtagac ggtgcgccac gcctgccggt gatcgacgta
       61 cagcttgcgg tagcccgtga gttcaccggt gaggccgatg ccgaacaggc gggcgttgac
      121 gacgtcctgg agctgggcga gggcgaggtc gcggatgtcc cctggggcct ggagcaggtc
      181 tgtcagggca cgggggtcga aggagaggct gaaggcaggg cggctctccg ggcggccggt
      241 catacgaggg cctgaatcgg acggcggaca gagcggcgga tcagctggga ccggcggtgg
      301 gccatgaccc ggccggcggc tctctgggcg gccaggatcc ggcgatcacc cgggatgacg
      361 aaccgcggtt cctcgccccg catgctttct tcgggcgcgg ggtgctcgcc ggcgggtgac
      421 gtgcccgtac ggatcgtcat cgcggcccgg ctccggccag ggccggggcg tggtccgtga
      481 gccgctgagg aggaggctgg tgtagggagg ctgggccgta catacatggt gcgggccgat
      541 cgtgttgcgg ccaagtcgtc ccacttgtcg atgagttgcg gatggtgggg gagctgggcg
      601 tgtgcggcgg gcgggctcgt catggcccgc ccgtttccgc tccgaattcg tcgagggcgt
      661 cgtcgaggtc gtcaaggtgt tccagcagac gccggatggt ggtctggcgc tcgctccact
      721 cccgctgctg gatggcctgc tccagctcgc actggttgta cgcggcggtc ggggcaccct
      781 cgaagtcgaa gagcaggtcc agcagggcga ttcgggcgca cgcctgtaag tcgggaaggg
      841 ggagggcggg gttggcgagg tggtatgcgt cgagcagggt cagcgcgcag gcgatccagt
      901 cgggactggt ggagacggtg cgcgggtcga atgccacgcg cgccagttcc caggcggtgg
      961 cgccccgggc gcctcggaag ccgatgatgc cggtgacctg gtcggcgagg accagttggc
     1021 tggtgcgtcc cgcgtcggcg tgcagtgcct gttccaccag ggcgtcgggt aactgccggc
     1081 ggagccgcag gacgtggcgg tcgaggtcat cgcggcgctg gtcgaggtcg gcgtgcagtt
     1141 gtccgtcgtg tgtccactgg tggcggacgg cgttgctcag cacggtggcg cactgggcgt
     1201 gcgcgttttc ggttggttcg gtgcgccagg ggctgggctg gacgtgttcg ggcggcgggt
     1261 aggcggtcag gacccggtgc atgcgcccga gtacggttcc ggtgtgctcg gcgagggggc
     1321 gcgtcatcgc cgaggtggac acgcggccgg gtgcttcgtc ggtcacgctc caggcgctgc
     1381 cccgcgcgac cgtcatgagg cagttgtcct tgtcgggccg tacgaggggg acgggaagcc
     1441 ccgcggcccg gcagtgctgg gatgtgtcga gcgcgacgcg tgcggggtcc cggccggtgg
     1501 tggagtgata ctccttgacg aacagccgct ttccctcgtc ggtgacgacg tgccggttgg
     1561 cccctttcct gctcaacttg gtgatctgca ttgatacgac ggtgagtccg tactgctctt
     1621 ccaagacgtc agccgtcagc ccacgactcc attccgtgtt atccatccag ctcacccgtg
     1681 cccgtgcgaa caggaaccag ccggtacggg gcgcctgcgg tctgatccgg accgatggca
     1741 acatgctggt gctgccgggg cggtggagta cgggtcacat gttctgccga cggcactcct
     1801 ctcccctggc gccgtcccgc cccggcatgt accggggtac aaaggaggtg accggtggcc
     1861 atcttggtga gggagtcatc gagctggccg tgcgcccagc cgagggtgac caggtgcggt
     1921 gcattgacgg cgccgacgaa cttgcgcagc gccgtgaccc gccgcagggc ctcgcctcgg
     1981 ctggtgcgga cgcgctgcgc atagaccctg gatggtgcgc cgatggcgag catgcgccat
     2041 gcctcgatgt gctggtccga gaactccccg ggggcggcgg cccgttccgg gcacgggagt
     2101 tggtgggtgg cgaaggtggc gtggacgacg gcggcccggc cgctcgcgcc gagcttgcgc
     2161 ccgcacaggg tcacctgcac gttgaccgag ccgatggtga gcgacagttc ggaggcgatc
     2221 gcggtcgtgg ccgcgccgta cgcgatcttc cgcacgatcc gcagctgtag aggagtcagg
     2281 ggcagaagcg ttgcgggcgg gcgggcaagc cgggtgctca cgggggaaat cctttcgatg
     2341 gaccgcggcc gacgccggat gtgcttcgac tcgccgaaga gggtggatct gcggccggtg
     2401 cgggcatgac cgacgttctc ctgtctgcac cgcatcgccg ggtgcagcac ggcaggctgt
     2461 cggtgtatgg ccgaccacat ggagtgatcg ccgttgccgc tgggctcgaa gtcgcaggtg
     2521 acgatcgtga tccgacgcac tgtcatggtc cttgtggctt gacggacata ccggtctggg
     2581 ccagaccgct gtccggcact ttcgggatcg aggcggccgg acacgccggt tcgcggctgg
     2641 cacggaggcg cgattcggcc cgtcttggct cggtctcggg gaacgacggg agggtcaggc
     2701 ggcgcggcgg cgggaggcgt gctgtgcgga ccactgatgc cgggcggggg agagcaggtc
     2761 gtcggcgatg tacttgagct ggatgtcgtc cggtcctgcg ggggcgttga tgagctggat
     2821 gtcgcgcagg atccgctcgc acgggttgcc gatccgtgtg gcgtgaccgc cgtgcagttg
     2881 cttggcgtcc tcggcggagg caacgccgtg acggttgttc acgagcttgg cgttgtacag
     2941 ccatcggtcg cacggctccc cgtggtccag gagataagcg gcgtgatagg cggcgagttc
     3001 ggcctgcatc agtcggaagg acatcttcgc caggcggcgg cgcaccatct tcacgtcggc
     3061 caagtggccg ttgtagcgct cgcgttcctc cgagacccat gtgatggtca cgtccagggc
     3121 ctgctggtgg atgcccagcg cgacggccgc gaggttgagc cggccgtaga ccaccgatgc
     3181 catcagagcg acgtcctggc cgtcgccgac ctcaccgatg atgttggcct ccgggacgcg
     3241 gacgccgtcg aggcggaggc ggtcgacgga gaatccgtac agaccgctgg cgggttggcg
     3301 gacgatgtcg acgccgttcc tgtcggcctc caccaggacc gcggtcaggc cgcgtttggt
     3361 gccgcgctcg cctgtccgga ccacgacgca gtggatgtcc gcgaggtcgg cgttgccgat
     3421 gaattccttc gcaccgtcga tcacgaggtc cccgccgtcg agccgggcgg tggtgtccat
     3481 gtccagcagg tgactgccgt ggcgggcctc cgtgacggcg atgctcggcc agacgctgcc
     3541 gtcggcgatg gcgggcagcc atcttcgccg catttcggcg ctgccgtact cgatgaccgg
     3601 cgcggacccg aggatcgacg cctggaggat ggctccggcg gccccgctga cgcgcgacac
     3661 ctccgttacc gcgacggtct ttgcgaggtg tcctgcgtcc ttgccgcccc actccgagcc
     3721 gatgagcagg ccgagccact gacccaggat cggtcgcagc tcacggtcgg tgtgcgggcc
     3781 ccgggattcc atgtccggga cacggggggc gatctcggtg tccgcgatgc tcttgacctg
     3841 ttcccggagg ctgtggtgat cgtcagtcag gtacgggctc gtggcgggca tcgtgaaact
     3901 ccccttctgc ctgcgtggct ggccactgcg gtgcggccct ggcgaaatgc ggcggtgcta
     3961 cgcgctggta cgccggtaga agtcggccat gaagagatcg cgctggtgat cgatggtgtt
     4021 ccatagcgcg cggccttccg agcgctgtcg cggctcggtg ccgaccccgc agattgtgcc
     4081 caagacgtgg ttggtgcgct cgtcgatgag aggggcccct atgtatacgc ggacgccgat
     4141 ctcgtcgacg accgggttgc cggcgaagtc gtcgtagtcg aggacgtcgg tcaggacgag
     4201 tgagcctcgg cgctggacga cgtgcgggca gaagccgtgg gtcagcggca tggagcggcc
     4261 caccacgggc agctcgcctc cggtggggtt ggccaggccg atgaagaact gctcgctgcc
     4321 gacccagttg agcatggcgt acggggtgcc ggccgcgcgg gcgacctgct gggcgaaggc
     4381 gtcgaacgcg cccacgggcg gagccgcagg gtcgaagtgg tcgggcagtt ggctctgcca
     4441 gtcaacgtcg tgaccggtgg cagtcaggag acctgacgga gcgtggggat tcacagcggt
     4501 gctccttgca gaaggtgggc agagacatcc gagaggttga gcacgtggtc gacgagacgg
     4561 cccaggacgt aagcggcatc cgctctcttg cgggcatcgc acagcacgac cggaaccgtg
     4621 gccgccagcg ccagggctgc tgagacttcg gcggggtcgt agtggctggc gtcgtcgaac
     4681 acgttcacgg cgaccaggaa gggcagaccg agccgctcga agtagtcgac cgcgggaaag
     4741 ctttcgtcga ggcggcgggt gtcgacgagg acaaccgcgg cgagggctcc tcgcgtgagc
     4801 tcgtcccaca tgaaccagaa ccgggtctgc cccggtgtgc cgaacagcat caggatggtg
     4861 ttcagctgcg ggagcgtgat ccggccgaaa tccatgccga cagtggtcgc cgtcttgtcg
     4921 aacagcagcg tgaggtcgtc cacgccctct gaggctgtgg tgatcacggc ctcggtacgc
     4981 agcggggtga tctcggagac ggcgcccaca aacgtggttt tgccgacccc gaacccgccg
     5041 gcgacgacga tcttggtgga ggtgggcgtc gcaccggcga acaggcgtga cagcccggga
     5101 tcagagcgtg tggagtgcat cgcgaagggc cttcaggaga gcaacgtcgg gaagggcagc
     5161 ggagtccgtg gcgctcatgg tgttcagtgc gccgatgtcg atcagtcggg acatgaggat
     5221 cctggtgatc tggaagggca gcccgatcag ggctccgatc tcggcgacgg ccaggggccg
     5281 tccccggcac aacgccacgg cctgctcggc ttcccgcggc tggccgggcg gcggttctcc
     5341 ctcggcccac agcagcgtct ggatctgcag gtcgtgcgtg ggcctggtct ggccgccggt
     5401 caggacgtag tggctggggg cctcggtgtc ctcgacggtc caggccgggc cgcctgtggc
     5461 cgccatctca ctggccgtca ccggaagagt ccccacccgc acgtgctggt gtggccagca
     5521 gctcgcccat ccggttgatc aggtcgacca tggcgaaacc gacggcgccc tcgtccgctt
     5581 tcgtggtggt cagtacaccc aacacgctct gcaccttggc cggatcacgt ccggcgttca
     5641 ccgccaccgc ggccggcggg tatccggcgc tcatgatgaa caggagccag ctgctcttcc
     5701 tgatgaggac ctgttcgacc gcgcccttgc cgtcgtcgat cccgtgggcg atggagtaca
     5761 tgccgttgat cactgcggcc agacggtccg ccagggtgcc gtccatcgcc ggtcccgcgt
     5821 gggccagtct caggccgtcc tgcgaggcga gcaaggctcc gttcacttcg ggcagccccg
     5881 ccaggtcctt gagagcctgg tccaggacca ggacctcttc cggctggact gccgtcgagt
     5941 cggtggtcat cgaattctcc gaatctccgt acgctgtacg gtcggtaccc aggtacgaat
     6001 ccgggcacaa aggatgtgga cgggacgcgg ctgcaagcgg ctagcccgcg ctcccatcgg
     6061 agggccgtgc cgcgggccgg ttgggcaggc cggccccgtg ggcctgctcc gcacgaagca
     6121 cgccctgggc gaagttgctg acgaaggccg gatccggcgg cactgtcggg gccggggcgg
     6181 catccggcac agcagaagcc tcgggttcac ggacggttgc ctgcggtgtc cgctgcggca
     6241 acctgggtcg agcgtcgtgc ggtgcgccct ccgaagacat cgccgcggct gctgccacag
     6301 cgaggggttg ttgcgccggg gcacgccgcc cagcgcggga gggcaatgcc gccatccccg
     6361 ccgggacctg ggccgcaacc gggacctggg ccggggggct gggccggggg cctccggccg
     6421 gctggaggac ggggcgggcc gcgaattgcg ctgccgggcc cggtgcggcg ccaccgtgtg
     6481 cgccaggttg agcccccgag ggggccgccg gtttgtcccg ccagagcagg agtttgttcg
     6541 gcaccaccac gagcgccgtg gtgccgtgca tgaggttctt ctgcagcttc acctggatgc
     6601 cgtaccggcg ggcgagtttg gccaccacga gcaggccggt ctggcgcagg gcgagttgct
     6661 cggccaggtc cgagtcctgg ggatcggcca gcatccggtt acggcggtcg atctcgccct
     6721 cggccatgcc gatgccgcgg tcctcgatct ctacggccag acccgcggtg acccgcgtcg
     6781 cgcgcacgat gacctggctg tccggcggcg aacagagtgt cgcgttctcc tccagttcgg
     6841 ccagcaagtg gatcagatcg ggtgcggcga agcccggtat ctgcacatcc agagtggatg
     6901 tgtgcatgcg gacccggcgg tacttctcga tttcccccgc cgcgccgcgt agcagatcca
     6961 ccagcccggt tggctggttg agctggcgtg ccttcacacc gcccagaacc gccagccgtc
     7021 ccgccgaccg ccgcatccgc ttgaggagat tgttgacctc gaacacgctg tacagcacgt
     7081 ccgggtcctg gacctgcttc gtcagctcag acacggtgcc caacgcccgt acgagcagca
     7141 gggtcatgcc cccggcgagg tagacgagcg cttgtgtcag ttccgtctgc cgcccgttcg
     7201 ccaccgcccg ccacgcttcg gcgtgcagcc ggagcagcgc ggcctcggtt tcgctccacg
     7261 ggttgctgtc ggagttcccc tgtggcgtac cgaagtcggg aggggaaggc cgctcgcccc
     7321 ggttgatctg ctccagagca tcgctgatgc tcttgcgtcc ctcgttcaca ccggactgga
     7381 aatgccgcag ccagccgtgt acggaatcgc tgtcctcgct gcgctgctgg tgcagcgcag
     7441 ccgccatgcg aaccgccagc cagtccgcgc acatcagcac ggcgagacca gtggctgcca
     7501 ccaccgctgc gatgatccag ccatccccag ggacgcggac cgtcgtactg acggcagccg
     7561 ccgtgcacaa gatcgccgag accaggagag cgggcacgag caccagaagc cgcagccgca
     7621 ggcgcagtcc cctctcggtg cgcagcggtt cggcatcgcg cgcacgccgt cgctggccac
     7681 gccggtgacc atgtgggcgc gggcatgaca gatcagacat tggcgacctc gcggaacgtg
     7741 gtcctgacag ggaggacgga aaggccggcc gggaccgggc gagcagcgca ccggcacaag
     7801 gtgcgcaaac agtggcggcc atgccgggac tcgggtgggc gtggccgccg gggcacgcgc
     7861 accggaccgc ggccgacggg ggaggcagcg tacggtccgg gcgcacgggg gtgccccggc
     7921 ggccggtcta tatgcggacc ctgctgaccg tctcggccac gctcgccaca acactgctga
     7981 tggacggtgc gagcgagatg tcgtggagat ggaaaccgag gagtacggct gctgcggcat
     8041 ggctggcctt gaggccgcct ttgctgatca gcagccacac caccacggcc agcacaagga
     8101 ccaaggagag ggtgatgctc acgaaagcga gtctctgctg ggggtatgtt cccgagaaac
     8161 cgcacgtggc cgatcagttg agcggcgatg accggcgagt ccgcgggagt tggggcgcct
     8221 gcgcaactgg tggcctcgat gatccaggca cggccgcgat aggccgttac gccggctaag
     8281 gcgggaaaca gggcgggcac ggtgtcctcc gggtgcgcag acttgtcgtc ttagcgtctt
     8341 gtccgcgacg cccgggtgac cgtttccggc ctgcgttgat tttacaggta aaccagggaa
     8401 gtaatcgatg ctctcaggtc ataagcctgt gaaaaatacg tggtgcacaa gggtgttggc
     8461 atccagatca ggaaataccg ctgctctgca tgcatcggtg atgcgggtca accgggctga
     8521 gaatctctcc attgttgtga cggcatcgtc ggctcaactc ctgaggggcc agtcgacgac
     8581 gaggcggctg tcgggcttgt ccatgacgaa gcgtgactcg gaggctgtga gtcggttgcg
     8641 ggcggcaccg acggccatgc ggaaagtggg ttcgggcaag tggcggcgac ctcgtcggca
     8701 agttcggcgg cgcgcgggcc gtggcccctg acgccgatct gccagaacgt gccgtgctcg
     8761 tcctcttccc tcttcgtgag gtaggccaag gagtcattgt cgcccccaaa gcatcggtgg
     8821 tcgttgcatc agctgacgcc tggccgtctc gcatgcggcg atacacctcc cccctcagtg
     8881 aggcactgag cgaggctcgc cccagccgtg ccgacagccc gcaacatcgt ggacagcacc
     8941 gattccggca gggagccgcg gccgaggcag ccgtcgtgga cgatcgcctc cagctcgcgg
     9001 cgtgaccacc cgccagccgg tggagcgggg tggcggagga tttcgcgtgc tgcgtacgcg
     9061 tcccgcgcct gcgtggtgtc gctgacgatc gcgtcgtaca gcgggcgtgc gaggacttcg
     9121 cagccttccg gcgccagatc gatcgccgcc aggaccagcc gcacccggaa catgcgcaag
     9181 tgtggcgggt caggctccag cgcatcccgc acggcgattg ccgtggcggc gaaccctttt
     9241 gctgtggcgc ggcccgccag gtggtcggcg tagtggcgga ggatctgcgc gacggcttcc
     9301 tcccatggtt cggtgatcgt ggccttgtcg atcagggaat tggccgtgtc ctgtgcgtcc
     9361 gtgtgcaggc tcgccacgac gtgtgcttgc ctgctgccgt acagccgctc gggttccttg
     9421 tcgtagacgg tcgcgtgctc tgccgcttga cgccattggc cggcggcgac caggagccgg
     9481 gttccgtcgt ccagcaggag gtcgtggagc cagggccgga tgtggttcaa ggtggcttcg
     9541 gtggtgaagc ccgtgaggcc gatggattgt ccgtggacgg tcacggtacc gccatcgtgt
     9601 gcggcgcggt gcacgctcat gagctgctga tgggcggcct gtgggtcgcc cgttcgggcg
     9661 gtcagtcgta cgaggttgac gatgggctgg aggctggcga tggcggtgtc cccggtgacg
     9721 ggccatgcgg cctggaagag acggagctga cgaaggcaga ggtctgtcgc caggtcggtc
     9781 agcccgcagt cggaggcgat cagcgcggac aggttccagg tggcgcaggc gaggttgatc
     9841 cggtcgagga ggggtccgtc ctgcgccgac ttctccccgc aggtgcggac ttcgtcgatc
     9901 cgggcggcga agttgcggta gacgaggtgg gatcggctga ccagggggaa gcgcccggag
     9961 agccggcgga gcctttccaa tgggggctgt ggcggcgcgg tcacggcatc ggcctttccg
    10021 tggggtcaac gggatgcagg atcgcggtat gtgccgcgtg agcgagaacg ctctgggtac
    10081 gggcgggcag gccgagccgg ttccagtgga agatcacgtg gtaggagagg acctcgcgca
    10141 ggccccggtc gaggactccg tcccgggcgg ctgtgccgag gtctcttccg gcctgccgaa
    10201 acgcgctcac ccagtcggcg gcgggtttga gagcgcggtc ggactggagc atggggccag
    10261 cggggctggt gtcagcgagg agtagctgtc ggaggctgtc ggccatggcg tggactttgg
    10321 cggccggaac gtctgaggga agaggacgtt cccgggtgac gcggtgccag acgtctcctt
    10381 gctcgtacca ctccagtccg gcggcgcgca tcagggtcgc gcacagcagc agtgacaact
    10441 cccggcggcc cagctcgcca tggccggtgg tgaggatggc gtggctgtcg gcgtggaaca
    10501 gggtgtgggc gatggtcatg ctgatgtcgc cgccgaacgc tgcggtttcg ggctcgtaga
    10561 taccgggcca ccagcggtgg atgtgcccgg cggccgtgag ttcgtcgagc aggccggcca
    10621 gcgccagggg aagctgctgc gtcccgacgg ccgggagcag ccgcatccgc cagcacgggt
    10681 gcttacggat gaaccaccac ccggtgatca gaccgtcctg ttgggccagg tccagaacgg
    10741 ggacgaggtg gtcggaggcg gtctgctcgg ccttgtccca gtcggtgaac tggatgtaca
    10801 gctgacgcca cgccggaggt cccgcctgct gggccagggc ctgttgcccg gcctgctggt
    10861 agaccgcgac ggcggcgtcc aagtcggcgg gctcgagtcc ggcgcgggct gcggcggtgt
    10921 tcatgtcggt gccggccagg acgtccagta cggcgtgcag ggtcgcgtcc aggagggagg
    10981 gttggttcag ccgatcagta ggcatgcgtc ccatcccgag gtcggcgcgg cgtcgtgggc
    11041 tgcggtgttc agggcgaggg cggtgcccgc gtcgccttgc aggaggccgg ggtcgccgcc
    11101 gggacgggcg tgctgggtca gggcggcggc caggtcgggc agggcggcgc gcagagccgg
    11161 gcctgcggcg tcgcgggcgg cgcggaaggt ggtctggtag acgcccgccc agccgtggca
    11221 caggccggcg tcggtgatct tggatagctg atcggggtcg gtcaggcagt ggaccagggc
    11281 gtcctcgtac aggtgctggc gagccgtgtc gcggcgggcg agggcggcga gctgtccggc
    11341 gcgggcgatg ccaggggtgc cgtagcacca actgggccgt cccgggccgc gttgaacggg
    11401 tcggccggcg cggagttcac cgaggtggag gtgctcgggc caccaggaac cggcggggcc
    11461 gtcctgccgc caggtgtcga gccagtgaag gatggtgtcg acggcgtctt cctggccgtc
    11521 gatcctcact ccttggcgca gggcgcgggc aaggagcagt agggggccgc cgatcccgtg
    11581 ggcggcaccg aagttggcgt ggccggcggg gacggtggat ggggtgaggt cgggctggtg
    11641 atcgacccac cagccgggca gcccgcccag gtcgtcgtgt cggatggggc gggtcagttg
    11701 tacgaggtag gccaggacgc gtgccatcgc ggtgccggac ggggaccggc gcaacaggta
    11761 cgcgccgatg ccggtgagcc cgtagaagat gtcgtactcg tggaagccgg ctggacggcc
    11821 gtggcggatg cgagtttgcg ctgcgtcgca tctgcggtgg gcgagttgag ccacgtggtg
    11881 gtccaggact gccagcgcgt tctggtaccg gggtgcctcg gcggtgacgg cgcagttgag
    11941 catgaacgct gccgcgggtg cccccaggta caggccgctg gtgtcggcgg cgctgacggg
    12001 ggtggcgacg gcggtcttga tccaggggtg tgcctgctgc catgtgccgt ccccggtgcg
    12061 ggcgcgctcg atgtgcagga gcgcggatcc tgcggcgccg gcggccaggt cctgcgccgc
    12121 ccaaggctgc tcttcaggcg gcgggagggg ggtggctagg tggcgggcgt aggtgtccgc
    12181 cagcacggct gggttggttg cggtggtcac ggctgccgct cccggtgtcg cagggcgcag
    12241 gctcgggcga gtcggccggt ggcgcgttcg tgctcggggt cgacgggcag cgcccgcacg
    12301 cagtgctcgt ggagcagcga cagcagcacg ttgtcggcgt tgcgtgcggt ggacagttgc
    12361 tgccggtagg cggtcagggc ggcggcgcgc tgccgccagg ccgcgatgac agctgggccg
    12421 cctggcaggg cttggagggc agtgtgctcg ggatcggcca gggcgagggc cagtgtgacg
    12481 cgctcccggg cgagagggcc gcgttcttga ggcagggcgc gggtcagcca gtccgacgcc
    12541 tgatctgcgt cgccggtgaa ccgcaccgtc aggtcgaaca tgctcgcggc ggtcagggcc
    12601 tgtccgatgg cggcgtcatc cgcggcggca cggatctggg ccacgccggc ggccgagtcc
    12661 gcggcgaaca ctaggtgcgc ggcgtccaga gcggggccat gcccgtacgg gccggacttc
    12721 ggcgggtggg tggtcaactc caggtggccc gccagacgtt ggctgccgag agcgtctgcc
    12781 cagccggtga cctgttgggc ggctgcgccg aaggcggctg gatcggggag gcgaaggtac
    12841 agatccagat gctggtcgga ggccggtcgg gtggtgtcgc gatggcgcct gaaccaccac
    12901 agcggcatgg tggcgaactg gtcgagcaga gtgggcaggt ggccggtcag gatttcgtcg
    12961 tagcgctggg ggtgcgcgaa cagccgggca tacaggacgg tgggctggct gggcgtcccg
    13021 gtggcggcag ccggctccgt caggcggggc gggtcggcgg gggtggagtt cgtcagaggg
    13081 atcaggagct cgtgggggcg gccgatccac gcccagtctt gcgcggtggt gctttcgcgc
    13141 agttcgacca cgcggttgcg gtccgcgccg gcgcgcagca gcgcccggtg gatgcgctgg
    13201 tcgaggtcga ggggcagctg ctggccgtct tcgaccagag caaggcgatc ggggacgcag
    13261 agccgttcac gccaccgggc cagtgccttg tcccagtcgg ccatgggggc ggaccggccg
    13321 ggcagttcct cggcggacag cagccaacgg gcaggcgtga ggatcgtccg cttgtaccgc
    13381 acgcgtggca ggtagggcag ggtggcggcg acgccgaagg tgaacgcccg gtaggcggcg
    13441 ctgcgggcgg tggtgatctc cgccaggaac cgggcgagcg gcggtgtgtg gacggacgct
    13501 tccagcgcgt gggtgacgcg gggctcgacg tgctgccccg ttgacctgcg caccagatgg
    13561 aaccggcggg tatcggcggt caccgccagg tcgtcgagcg ggatcacgcc ggggccgggc
    13621 tcgtggtgct ggccgagagg gatggtgaag ggcaggacct gcacggtgcg ggtgatgttc
    13681 tcgttgcggc gccggcgagg ggcgaacgac agctgcgccg cgatggcgcc gggtccggcg
    13741 gtcgcatacg agtcggtgag cgcgctctgc gcggacggcg ggagcaggtg cgcgaaccgg
    13801 ccgagcatgc tgctgccggg gcggggggct ccggtgacca gcagccggta gtcgccgcac
    13861 tgcacggcct ccagagtggg ggcgtggatc tccacggcga gctcggcccg gggcacgggc
    13921 agcagcggtt cggtgtggtg ggcggtcagg tcggcgatcg tggcccgggt gaggaccagc
    13981 tcacgcctcc cgtcgagcat cgcctcctgg agcaggcgca ggatcttctc gtcccggtcg
    14041 gtcacctcat atggcgggcg ggcgcgctcg gaccccagga agcccgcggg caggccgagg
    14101 ccgctatccg cgaccagatc cagtacgggc acgagggcct cgttgccgta ccggtcgagg
    14161 aaccgctggt ggtagtcgcg ccattgcgga tacccgtacg gatgaggtga cagctggtgc
    14221 atgacctggg ctgcctcggc ggcttcggcc aggagggctt cggggatgtg ggcggtgcag
    14281 tccagtgcgg cgtcgaccag cagcgggacg cggccggtgg cactcacgta ctgcatgctc
    14341 tgcgtcagcg ggtcgccgag cgtccagggg gcgacggtgt ccgggtgatt caagccgccc
    14401 cggatcgaag cgaggtggga ggccagctct gcgatgtcgg gtatgccggt ggcgtctgct
    14461 ttctccagct catcgcatat gtgggcgagc gtgtcgacgg acgtcattgg gggccacaga
    14521 ctgctgatca ggacgtgctt gctcagtagg tcgccgatca ggccggcgag ctgctcgggg
    14581 cgcgcggtgg ggaactgccc ggacagacgg tgcacgagca gctcgtacgg gaccggggtg
    14641 cgggcagcct ccagcacggc ggccacgggc cgggtgaggc ggaccgacag ctcgacgggg
    14701 gcgtagccgg aggtgtgcgc gtcggcaggc atcccgtcca ccacgtgccg gttgccgcgg
    14761 gggcggccgg tgttgttggc cacgaccgtc agccgggcca ccagagcggg gtggctctcc
    14821 aggcgggtga tgacgtccgt cagccagtcg gagtcaggac gcagaacagt ccggtacccc
    14881 tcaccccaca gaatgcgggc ggcttgagcg ggctcagcgg gagcgacccc ggcgaatacc
    14941 ccgaacgggg tgggccggtg gttccaccgc aggaggtacg cggcaacgga ccggacggcc
    15001 cgcctgatac ggcggtcgtc ggtgacggcg ccgttcagga tctcggcgac gcgctgacac
    15061 aggacggggc tggccgcgga cagcgccgtc ggcactggag cgcgccatac ctcgtccagc
    15121 caccgccgac cgcggatcgc ggcgtcgtca ccgtgcaggt caaagtccgg cacagggatc
    15181 ggctgtgaag cggtggaggc gcgcagcagc attccgggct gccactgata cgtgaggggt
    15241 attccgtggg ccaccggtgt cccttcctgt tgtggggtgc gcggatgggt ggagccgggg
    15301 cggcagcgat gatcggctgc cgccccggcg gacgccacgt gtcaggcggc gtcctcgatg
    15361 gaggactggc aggcgctcgc cccgttcacg caggtgttgc cgcagccgtc gctggtgggg
    15421 cacatgaaga cggtgagggg gctctcggag atgacgaccc ggatgtcgag ctcgaagtcg
    15481 tcatcggcga gggcgtcgac cggcaggccg agcggggccg ggacgctgtg caatacggcg
    15541 gtggtcatgt gatcactctc tttgtccgat gggatggtgc agaacgccct gacccagcgc
    15601 cgcggttcag acggccggcc aggagatcga aatccggctg tgcctcttgt cgatgatccg
    15661 gtcgccggtg atccggtcat cgggcgtgcc cgccgggtaa acggcgatgc gtggcccgtc
    15721 agtgccgcgg acctttgcgc cccaggtgcg aaggatgtcg gcgattcgct cagcgaactc
    15781 ggccgcgtcg ggcccgaagg cgtggacccc gtactctgcg gtcttcttct cgctgtcgcg
    15841 gcgcacgacg gtgtaggcga agtgcggccc gtcgatggcg accatggacc agccgctgcc
    15901 cgtgggaccg atcctgccgg cggccaactc cgggtcggtg gacatgaagc agtaggtcgg
    15961 gacccgcgtg gacagataca tctggagggt gccgatgggc tcctggctgg cgacggtcac
    16021 cccggtccac gtctcggcgc gagcgctgtt caggacgccg tccagcagcg acgggttggc
    16081 gggcaagccc tcgtcgaagc gcagcgtcac gccctcctcg ccggggaact gcatgacctg
    16141 ctgcgcgtgg gagccggcgc cctgtgccgc cacgaaaccg cacacgtggg cgctggtggc
    16201 gacgagatgg tcagcccgcc ggacgaaccc gtacgtgcgg gtcaggccgt tgatgcgcag
    16261 cggcacgacg agccggccgt cgtccttgag ctggtcgatc caggcgggcg ggatgtccca
    16321 ggcgccgacc gttaccacga tcgcgtcgta gggggcgtgc tcgggaaggc cgttctcggc
    16381 gtcggcgacg acgacgttga cgcccgtgta gccggtctcg gtgaggaacc gctgggctcg
    16441 gtctgcgggc gcggggtcga tgtcgacggt ggtgacctga ccggtgggcc cgaccagttc
    16501 cgcgaggtag gcggcgttcg gcccgttggt gccgatctcc agcacgttgt cgcccgggcg
    16561 gatgccggcc tgctccagct gcatcgcttg gatctgtgga gcggacaccg agctggtgtg
    16621 attgccgtgc tcgtcctcct gggtgatcac ggcgttgtat gtgctgtaag cgttctccag
    16681 tggcgcctcc ggtacggcga ggtgccgggg caccttgcgc atggcggcct cgaccgcggg
    16741 cgacacgatc gtgcggtcct ccttgagctg gtcgacgacc ttgttgcgga gctgggtggc
    16801 ctcgtcgggg gccatggtca catcggtcat agaggggttc cttacggggc ctcgtgcgcc
    16861 ttcgcctccg gcgtcggcgc caactgcgtg gtggttcggt gatggatgcc agctggtgga
    16921 agccgactgt cgttcagtgc cgcaggggca gctcctggat acgttcgaaa gtggaggtgt
    16981 ggcggccggt ttggtgcgtc tccgtcacca gccacacgaa ctcgatgtgt gcgaccacgt
    17041 gatggtgggc ggggcgcagt ctggaaagcc cagcggcgcg gatcatgccg acggtcagct
    17101 cagagcactg gttctgggcg ggcgtggtcg gtagccgggg gttgagtcgg tagtaggtgc
    17161 cgaatcggaa cagcgctggt gtcacggcgg actccttcgc gcatcgccgt gtgtgcgcgg
    17221 ccgaggcggg cgggaggaat ccacggggta gcggtgggcg ggtggatgat cgatgggcag
    17281 gtcggggcgc cagcagcgca ggacctgtgc ggagggcacg aacagtgggc tgggcaggga
    17341 gtccagcggg tgccagcgcc attccgcgac ggtcttcggt ttcctggtgg tcggtgtgcc
    17401 gtcgaagcgg cggatcacga cggcggcggt gaggcgtttg atgtcgtgtc gtgcgtccag
    17461 gagcagcgcg aggacccgga cgtccttggg atctgccacg aggccggtct cctcggcgag
    17521 ttcacgcatc gccgcgccct cgatcgattc gaccgcggag gccgatgcgt ccactttgcc
    17581 gccgggtaac tcgtgggtac ccaggcggtg ttggcccatc agcacgtggc cgtccggatt
    17641 ggtgacgatg acgccgacgc ccagggccgc ctgtgggaga ggtgaccact ggctgcgttc
    17701 ctgtgtcacg actcggggcg tgtcggggtg gatgaggcgg cgggcctgga tgagctggac
    17761 cacgacgggg ttgtcggtgt ccggcgcgtg cagcagttcg atggactcga cggcgaagcc
    17821 gttctcggcc aggagccgct cccagacgtc gggggcgaga atccacatct gcaccgggat
    17881 cggtggggtc tgcgccagcc gtatctcctc ctggcgggag gcgacggttg aggagggacc
    17941 cagcccgtcg agattggtgt gcagggtgga gaacaccagc cgcccgcccg gccggatccc
    18001 gtccctcagc atgggcagca gcctgcacgg atcgatatag gagaggccgt gcacggagta
    18061 cacgaggtcg tagggctcgg tgtcgcgcag gtgtgccacg gcgtcaccga ggaggaaccg
    18121 cacgcccggc aggtaggtga accggtggcg ggcgcgctgc tgctgggtgg cggagatgtc
    18181 gatggcgtcg atgaaggccg agtgggcgcg ggcgaggtgc gcggcgtgga cgccggctcc
    18241 ggagccgatg tccagcacgc ggtgtccggc gatgttgccc aggacggtcg taccggggcc
    18301 ggttccccag aatccccagt cgatctcggt gacttccggt ggcctgtagc cacggtcgag
    18361 ctgccgctgc ccgtactcca gccagccgtc ctcgttcacc tgttccggtg tcacggaatc
    18421 gggggtgctc acgccgcgtc cttccgcagg cggtacaggg tgcggtggcc gcgttcgacg
    18481 agttcggggt cgccgtgggc cgcgccgtac tggataccgc tgagggcgtc gagcgctgac
    18541 aggccctgca atgcccgggc ctcgtcgggc gacagcgagc gggcgtagcc gtcgaagatg
    18601 gctgcctggc gggccggggc gttcgcccag gtgtcggcga tccggatgaa gtcactgacg
    18661 agggggccga cttcggcccg ctcgaagtcg atgagggcga gcagcatgct gtcgtcgagg
    18721 agcaggttgc gcagttggat gtcgccgtgg cgtgggccat ggggaatggg cggcagggtc
    18781 gtcaggcgct gggcgaggcg gcggatcagt ttctcctctc ccggttccag gagtccgtcg
    18841 gccgcggcca ggtggcggtc cagtttcgcc aggccgccca cggcgggcgc catcatggcc
    18901 ggctcgcagg agtgcaggac gcgcaggagc tgtccgagct ggcggtagac cgcctgccag
    18961 gtcggctcgt tcaggtcggc gccgtgaaga ttgatcccgg catgggcggt gacgacggcg
    19021 gcgaactggt cggggtcggc ggccacgagc tggggtgcgt gaccccggcc gagcgcggga
    19081 acccagcgtc ggtaggccgc cacctcgcgt tcgtggaacg tggtgttctg gtgcaccttg
    19141 aggaaccagc tgccgccgct acggccggtc agcttccaca cgcgggatcc ttcgcgcgcc
    19201 caggacgagt ccgtgacggt gtgcagaggg ccgatggcct gttcggcgaa gtcggagagc
    19261 tgttcgccga gcatggcgcg cgcgtccgga gcccggctgg gcagtgggta aaggcggctg
    19321 ggcccggctg gatcgtaggc gatggggtcg cccggctcct ggaggtgaag ggccgcggtg
    19381 tggccatgac ggtacgcgtc caggccggca cggcagtagg cgaccatgtc gacgggaggc
    19441 tcgttgaggg ggaaccagcc gagttgggag cagcggtccg gctcggcgat gcgcgggtgt
    19501 ccgaaccact gggtgacctc gaagaaccag ccagtgcggt tctcgccccc gggagagcgg
    19561 tgctgcatca ccagcgcgaa ccggacgttc tccgggcgga tgaggacccc gagttcctct
    19621 tcggcttcgc ggatcagccc ggtgaccacg tcctcgaagt cgccgtcgag atgcccggac
    19681 ggcatgtgca gcagccccga ggcataggtg tcgcccgccc gccggctcag cagcacctcg
    19741 ccgctacgcc gcaggatgag atggacgtcg accggttccc ggtggcgctg cacgatgtcg
    19801 tccccgcccc gatgcgaggc tacctgcccg ttcaccgctg gcctgccaga cgggggtgcg
    19861 gccgactcgc atccgggcac cgcggcgtgg cgtcggtgaa ctgtcccaca acggggttta
    19921 cgggaacgcg cgagaaggcg ggggtgttgg gcatgcggat ctccggggtg cagacgtgac
    19981 gtccagcgtc agtgaccgcg acgcccgggt gcccgtttcc ggacgccacg gagtctagcc
    20041 ggaacaccaa agggagttgg ctggtcaccg gcttgatcac gccggtctgc tgatcacaca
    20101 gctcggccat gcgcggcctc ctttcgggcc gtgccggcgt acgacgcggc ttggggcagg
    20161 actgggtaat cgagtgccag tgcctgtgga gcggtcaggc ccggggaggt cagctgccag
    20221 ccgtcgaaca gccgggcgat ctgttccttc gtccgcaggt ggacggggca gccggccgcc
    20281 gtcatcgtct tggcgaatcg gcgcacgggt ttgcccgaga cgtcggcggt ggcgtgcgtg
    20341 atgacgagag cgctgccggt ggcggcgacg tgtttgtact ggtcgacgag gacggtcagg
    20401 ggctgcgccg cagtgtcctt gatgtagtgg agcacgctgc cgaggagaag gatgaccggt
    20461 tctcgccagt tgatcgtctc caggatttct ctggaagcga gaatcgactc ggggtcgcgt
    20521 acgtcggcgc acaggctctc gacgacagcg ggcgccttgg ccgtcatcat ttcttcggcg
    20581 tgggtgtgca ccagcacgtc gttgtcgatg cacatggcgc gggcatcggg atgaacgcgg
    20641 gtcaggacat ccaccggcgt tggcccgtga ggaaggccgc agccgaagtc aaccagctgc
    20701 cggacgcccg cgatggccag ggcctgcacc atcaggagca cgtacatacg ctcgtgacgg
    20761 acggcgctct ccaggaacgg catacggtcg gcagcccgaa gggccccctc acggtcgacg
    20821 atgtagtggt ctcgcccgcc tagcaggtag ttctgcatcc gggcgctcga cggccgtgcc
    20881 tgcaactcgg cgatcgctcc ggaagggtgg agaagcatcg ggtggtcagg gcgcatgccg
    20941 ctccacccct ccggtgatcg tgtggagttc gggcagacgc cacgacggac cgtccggtgc
    21001 accgagccac agcgtgtgtt ccatctccgt gatcgtcacg cccagctgct ccacctctgg
    21061 ttccccggcc gcgtgccact gaccgagcgc gtcgaacaga tcggagccga gatcacgcgg
    21121 cccccactcg tagacgcgag gggagtgcag gaagaccacc gcccgagacg cctggtggtc
    21181 atgaatacgc aagcggtcgg caacatcgcc ttcgaactgc gcaacaccgc gcaccacctg
    21241 cattcgaagg tcagggcgaa gcagaccggc gaacaaccgg gccgccagcc gtacgtgcgc
    21301 ccccctcgcg tcggcttccg acgccctcgg gctgccctgc gactcgacgg agatgccctc
    21361 accaggacgg tgctcgcgaa gccacacggt ctgatgagcc ggtccagcgt ggaaacgccc
    21421 actggccgac gccccgtccc gcgccacggt caggacgagc agcgtgctgg atccgcccag
    21481 agcggtacgg acgggcagac acagccggcc acccggacga atccgggtga cccactccca
    21541 cggcacatgc cgcaccgcac gatgggacag gagcccgtgg aacgaacccg ccggccccat
    21601 gaccccggcc tcagacccgt tgaccacccg aacccgcggg taggggcgta ggcgctgccg
    21661 ggcgatctcg gcgagacgtt ctgtgtccgc gaccgtcacc acctggccgc cctggagaag
    21721 gtgttccaga gaggctgcag tccagccgca gtccgtgccg acctcggcaa cggtcatccc
    21781 tggctctgga gcgagcgcgg ccaagcgcgc cgtggcgtct tccttggacg ggatcactcc
    21841 cgtgacgatg cccgggccgc cctccccacc atcgtccacg tcgaacacga gcatctcgga
    21901 gcgatggacg aacttcgccc actcgcccgc gttcttgctc cggtccaccc tgcgccagcg
    21961 accacctcgg tgcgtacgga tcacgttggg cacgaagtcc tgtcgccgat cgcaggtgaa
    22021 cacgtccccc gcgtgctcgt gaacgtgggc tctgcccggt cgcaggctgc tggcctcgac
    22081 gcgggcgttc atgcctgtcc tgccacggaa acgacgtctc cggagttttc acggccgctc
    22141 gcggggccca gaaggcggaa ctgccaccct cgcgtgaccg cgtgcgcggc cgaggaagcc
    22201 cccagcgccc gcagcagacg tcgagcgtcc ttgcgcacgt cgtccagcac acgcttcgcg
    22261 tcgaccgcga tctcctcgac agtctttccg ccggcgagcc ctgccaggac ggtgcgctgc
    22321 tccttcggca gttcgacgtc gtaggccacg agcatgggga cgtccaagtg cccgtgccgg
    22381 taggcgaggt ccaccatgcc cgcccgctcc gaagttcgga gctttccgcc gatccggagg
    22441 atgtacgtct tgaccgtgct gtcggacact cccatgtcgc aggccgtctc tgcggtcgtc
    22501 cttccctgcg agatgcccag cagagcctcc cgctcctgag aggaaagcgg tggcgagatg
    22561 gtctcgtccg gggctggcat ggtcgtactc cttcggtgtt ctggcacagt cgtcgtctta
    22621 tcggggccgg cccacttcgc tggtcagctg gctggggcgt gtgctacgac cggccgtaga
    22681 actgcagggc gagttcggcg aggacacaga cggtggggag gctgatggcg gcagcgagga
    22741 ggacggcgcc ccagtgcgcg cgagcctgtc gccagccacg ccgaaggcgc cctggggctg
    22801 gctcgtcttt gcggggcgag cccgaattcg gtggggaggc cggagcccgg tgaatccgtt
    22861 gagggtgcgt cgcgcgatag gacctggcca tgtcactcac cgtccctctc gcagtcctgt
    22921 tcggcgtagc gcagcagggc ctcggtgtgg accgcgagac ggaatgcgtg ctccctcgcc
    22981 gccctgagtc cctcgcccgg agggacgtcg cgggcctcct gagagcgctc gatcacttca
    23041 ccgcatgcgg cccacccccg actcccggag gcgagtgatt ccaagtggat cgagacgtag
    23101 gggacgagcg tcgtgacgta gccgccgagc gctcgcgtga ccgccgcgag ggtaggcgga
    23161 tgcgggtaca cccccgcttg ctcccaggac ttcgccgcac gaatggcctc gcggatacgc
    23221 gtcgaatcga acccagcgca cacagccctg tcccagccat cgaccacgtc gtcaaaggcg
    23281 tcgacagcag gaaggacggc gagcagctca cgcccgacct cggacatccg ccggtgcagg
    23341 aacgccgcac gcccggcgtc gccgggaatc tcttcgtcga gcaggccacg cacgcgtacg
    23401 accagtcgat catcttccag aggaggctcg ttggcatcga cgggaacaat tgctccgaga
    23461 agtcgcatca agtggccgcg catgagcagt agttgaacgt gtcgctcgtc cgggtcttcg
    23521 ctgacggagg cagcctcagc gaagaccagt ctggtcactt cgcggtgaag ggcctcctgc
    23581 accgcgagag gcgacggtcc gggtgcgagg gttgatacag cggtcctcag gtcacggccc
    23641 agttccctga atgagccctc cggccaggac acgccgtcca cctgcccacc gccgactgcg
    23701 ggggccgagg ttgtggtgcg aggcataagg acaactccaa tagcgagatc cgaagttggc
    23761 gatcgggatg tcgcctcggc ggcccccaaa gaggagccgc cgaggcattt cgagccgcca
    23821 ctcgccgaca agggcggttc gttcaaggaa gacacggtgc ggtgagttac acgggcatcg
    23881 ttcagggagt tcggagacgc cggtaccgcc gcacaggact tgggcgggac gtcctgggac
    23941 gtcccgttgc cgggatcact atcggggcca agtaacccac ctgcggtgtg ccgttgaggc
    24001 tgaggcgttc tgttgtggct ctcaggtggc gctgttgagg acatcggagg ggatggggat
    24061 gcagctagtg gattcatctc gtcggtggag cgtcgctggc tcagtcctgc tgcggtttca
    24121 ggcgtgactg gggtcatcac gacctccttg cagggacgcg gaagacgcac catgtcgtcc
    24181 tgccgtcgtc gctgacgccc cactctcgtg agaggacggc gatgaggaac aggccgcgtc
    24241 ccgacaggtc ctcgtcgtca gcggggcgca gtgtggctgg ggtggggttg tcgtcagtga
    24301 cctcgatccg caattcgccg tcggggtact ggatccgaag tcccacgtct ccggttccgt
    24361 gttcgagtac cggtaggcca ctggcgaggt gtccgctgaa cggatccttc tccagtggcc
    24421 cccggtccga acccgccgtg caccctttcg atgcagcggg ctctccagtg acttgtgcgt
    24481 gttcctcatc cttggtccgc atggatccct ccgtggcaag gcgggcagac cacgagagtt
    24541 ctgcgccgct tcttgagcat cagctgtgcc catgcggtcc gttcaccctt gccgtgaagc
    24601 cctgcgaggg agcgaacttg gtgtacttcc accgaagatc gctcatcgca gagttcgcac
    24661 catcccttgc ggagccggtc gatgagctga ctgccgcgcg ggcggctgcg gggggtgaac
    24721 tgggtgggcg gcaggtcgtc gatgacggcc gtccgcttgc gggtgagggg aataccaccg
    24781 aaccgtgcga tcagtggttt tctgcctggc cgttcgaccc gggcctcgaa gcacctgcgt
    24841 ggtccttggg gtgtcttgat ggtggttttg tacttgttgg ccatcgtcgt caccctcgac
    24901 cggtgcttgg cggccagggt cttgagcagg gaggtcagca tgaccccctt gagccggtcg
    24961 agtctccaga cgtcgccggc cagcaggtag tactgaacga tgccccggta ctgcgctccg
    25021 tagatgccga cgatgtcaag gggtgtgcat acggtcagcg ggagcaggtg cgcgggtttt
    25081 ccgtgcttga ggaagggggc gcatttggct ttgatcacgt ccttgggcac ccggagttgg
    25141 atcttcccgt tgatggagcg tgcaccacgg ttgatgcggc cgccccggga gatcttgtcg
    25201 tcggcgtgct ggacggtgat ctcgtagccg aggaaccgtg cggcctgggt gcgg
//
