LOCUS       NZ_CP089312            23875 bp    DNA     linear   CON 28-JAN-2024
DEFINITION  Streptomyces sp. GQFP chromosome.
ACCESSION   NZ_CP089312
VERSION     NZ_CP089312.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. GQFP
  ORGANISM  Streptomyces sp. GQFP
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8306813)
  AUTHORS   Zhu,J.
  TITLE     Complete Genome Sequence of Streptomyces lacrimifluminis strain
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8306813)
  AUTHORS   Zhu,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-DEC-2021) School of Life Sciences and Biotechnology,
            Shanghai Jiao Tong University, Dongchuan Road No.800, Shanghai
            200240, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 4; canu v. 1.6
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 109.0x
            Sequencing Technology             :: Illumina HiSeq; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/28/2024 04:27:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,499
            CDSs (total)                      :: 7,422
            Genes (coding)                    :: 7,228
            CDSs (with protein)               :: 7,228
            Genes (RNA)                       :: 77
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 62
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 194
            CDSs (without protein)            :: 194
            Pseudo Genes (ambiguous residues) :: 0 of 194
            Pseudo Genes (frameshifted)       :: 69 of 194
            Pseudo Genes (incomplete)         :: 156 of 194
            Pseudo Genes (internal stop)      :: 7 of 194
            Pseudo Genes (multiple problems)  :: 35 of 194
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:04:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1903623
            Orig. end                         :: 1927498
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP089312.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23875
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="terpene"
                     /product="butyrolactone"
                     /region_number="6"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /rules="AfsA"
                     /tool="antismash"
     cand_cluster    1..23875
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /detection_rules="AfsA"
                     /kind="neighbouring"
                     /product="terpene"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..22157
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22157
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12157](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12157)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            576..2321
                     /gene="treZ"
                     /locus_tag="LUX31_RS08345"
                     /old_locus_tag="LUX31_08345"
     CDS             576..2321
                     /GO_function="GO:0016798 - hydrolase activity, acting on
                     glycosyl bonds [Evidence IEA]"
                     /GO_process="GO:0005992 - trehalose biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="treZ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CBM_48"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1297: Pullulanase, type I"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006381306.1"
                     /locus_tag="LUX31_RS08345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_08345"
                     /product="malto-oligosyltrehalose trehalohydrolase"
                     /protein_id="WP_235474139.1"
                     /sec_met_domain="CBM_48 (E-value: 6.8e-05, bitscore: 21.8,
                     seeds: 59, tool: rule-based-clusters)"
                     /sec_met_domain="Alpha-amylase (E-value: 6.1e-11, bitscore:
                     41.2, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHFEVWAPQASRVTLQCDAGTRALERDPERAGWWSGEAEAREGSR
                     YGFAVDDGPVLPDPRSRRQPDGPDGLSAVVDHGLHTWRTEWAGRALPGAVLYELHVGTY
                     TPEGTLDAAAGRLGHLVELGVTHVELMPLCPFPGRHGWGYEGVSLWAVHEPYGGPEALK
                     RFVDEAHALGLGVVLDVVHNHLGPSGNYLPAFGPYFTDTHQTPWGSAVNLDAPGSDEVR
                     AYLLGSALAWLRDYRVDGLRLDAVHALRDTRACHFLEELSTAVDALAAELGRPLSLIAE
                     SDLNDPRLVTPRAGGGLGLHAQWSDDFHHALHTALTGESKGYYEDFARAPFAALAKTLT
                     GGYFHDGTYSTFRGRLHGRPLDRTRVAAHRLLGFTQTHDQIGNRAQGDRLSASLSPGLL
                     ACGAALMLTGPFTPMLFMGEEWAAGTPWQFFTDHTDADLAEAVRRGRRREFTAHGWAEE
                     DVPDPQDPATRDRSCLDWSEPGREPHARVLSWYRELIALRHAQPDLTDPDLSDIKVAYD
                     EEARWLAFRRGDVRVVANLAAKPAAVPLGPRQATVLAAWEPVELPGADGLLHIPGESCV
                     VLEQG"
     gene            complement(2424..3371)
                     /locus_tag="LUX31_RS08350"
                     /old_locus_tag="LUX31_08350"
     CDS             complement(2424..3371)
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006381333.1"
                     /locus_tag="LUX31_RS08350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_08350"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_235474140.1"
                     /sec_met_domain="APH (E-value: 6.3e-24, bitscore: 84.0,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQAPTPTADTVRRLVRSLLADSALGTSATAGPDVRPVGAGGEAS
                     TWWVGARHVLRLAPDRDASARLRRELRLRDLVRPHLGVAVPVGVAHGEWAAGLAYTLDT
                     RVPGGSAEEHDVSAVGEADLAALLTGLREVPARQAETLGVPRVAPRSLEALRRAAERAA
                     ERLAAADEFDPARLHQLTPAAATQLAAQAGTAVLVHHDLRGEHLVVSADGRVRGVLDWA
                     DAVVGDPAEDIAGLALAVGSPAAVRAATLAGYAARPCLRGLWLARCDTIVRLAESLTGR
                     DAGPRPLLRVQLRRAWEAILLERVTELREQDEEG"
     gene            complement(3432..4559)
                     /locus_tag="LUX31_RS08355"
                     /old_locus_tag="LUX31_08355"
     CDS             complement(3432..4559)
                     /EC_number="3.4.11.9"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0070006 - metalloaminopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1172: methionine aminopeptidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996926.1"
                     /locus_tag="LUX31_RS08355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_08355"
                     /product="aminopeptidase P family protein"
                     /protein_id="WP_235474141.1"
                     /transl_table=11
                     /translation="MTGSSPAPFTADDYRARMRRAAREAEDAGLAGLLVAPGPDLVWLT
                     GYAPTAVTERLTLLVLAAGQDPVLVVPALEAPDAAHAAGAPALTLRDWTDGKDPYAATA
                     PLLDAAGRFGVSDNAWALHLLALQKALPGTSYVSLTEGLPMLRAVKDAAELTRLAAAGA
                     AADATYEEIRKVPFGGRRERDVAGDLADLLRRFGHSEVDFTIVASGPNGANPHHEAGDR
                     VIERGDMVVLDFGGLLHGYGSDTSRTVHVGEPDAERRRVHDIVREAQEAGFRAVRPGAA
                     CQDVDRAARAVITEAGYGEYFIHRTGHGIGVTTHEPPYMIEGEERPLVPGMCFSVEPGI
                     YLPGRFGVRIEDIVTVTEDGGRRLNNTTRELVVVD"
     gene            4773..5528
                     /locus_tag="LUX31_RS08360"
                     /old_locus_tag="LUX31_08360"
     CDS             4773..5528
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006381334.1"
                     /locus_tag="LUX31_RS08360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_08360"
                     /product="metallophosphoesterase"
                     /protein_id="WP_235474142.1"
                     /sec_met_domain="Metallophos_2 (E-value: 3.6e-08, bitscore:
                     32.4, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLVLAHISDLHLDGTARSIARAERVRDRLWELPGHVDALLVTGDI
                     ADHGTEAEYEEAARILGLRTGDAPFPVLTCPGNHDSRAPYRKALLGLPAAEGPVNSAHV
                     FDDAAVLMCDSSVPGRDEGALDDETYDWIDATLDELDEGVPALLAFHHPPVALHHPLPD
                     SYQLGRPDRLAALMERSPQIAGLITGHAHTPAATTFAGRPLVVGPGVTWTLQLPWEGEE
                     VADRDAPVGLAFHVLADDGRLTSHFRVVV"
     gene            complement(5590..6276)
                     /locus_tag="LUX31_RS08365"
                     /old_locus_tag="LUX31_08365"
     CDS             complement(5590..6276)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006381304.1"
                     /locus_tag="LUX31_RS08365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_08365"
                     /product="PDZ domain-containing protein"
                     /protein_id="WP_235474143.1"
                     /transl_table=11
                     /translation="MEQTALRPKPMPGQEPAGGTTTRPARRPHAAPRRGRRLTALLFGL
                     FVGAVLVLAGVGLGTLGATVIGMSKLADLQRQAGQDGQAGQQGQGQGPDSAGARSGAPA
                     ESGPGSGAESRSGPGSGSGHSRQPSDGASPASSASAVTATLGVEAVDAEKVGALVVGVH
                     IPGPGYTAGLVRGDVLLTFGGARVDSAADLARVVARARPGAEITLTVRHRSGGYQQLVA
                     IPGVVT"
     gene            complement(6389..8260)
                     /gene="phsA"
                     /locus_tag="LUX31_RS08370"
                     /old_locus_tag="LUX31_08370"
     CDS             complement(6389..8260)
                     /EC_number="1.10.3.4"
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0050149 - o-aminophenol oxidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="phsA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018535576.1"
                     /locus_tag="LUX31_RS08370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_08370"
                     /product="O-aminophenol oxidase PhsA"
                     /protein_id="WP_235474144.1"
                     /transl_table=11
                     /translation="MTDIIERPTESITGEQAPAPGELTPYVAPLLVPPVLRPASEDVLK
                     ETEIALRPAWVRLHPQLPPTLMWGYEGQVPGPTIEVRRGQRVRIAWTNRIPADGEYPVT
                     AVEVPVRAPGTPPATTEPGREGVEPNKDVAALPAWSVTHLHGAQTGGGNDGWADNAVGF
                     GDAQLSEYPNDHQAVQWWYHDHAMNITRWNVLAGLYGTYLVRDDEEDALHLPCGEREIP
                     LLLADRNLDTDEDGRLNGRLLHKTVIVQQQNPETLKPVSIPFTGPYTTVNGRIWPYADV
                     DAAWYRFRLVNASNARIYNLVLVDEDNNPVPGVVHQIGSDGGLLPRPVPVDFDGALPTL
                     TAAPAERFDLLVDFRGLAGRKLRLVNKGRAQAPGVPDPASDVRYPEVMEFRVREECVSD
                     SFELPEVLSGSFRRLTHGIEHGHRMIVLTPPATKGGGGHPEIWEMTEVADPTGIQFPAE
                     GVIQVTGQDGTTKTYRRTARTFNDGLGFTIAEGSHEQWSFLNLSPIVHPMHIHLADFQL
                     LGRDAYNVSGFDPAVGGTRSPIAFDAATQIPLAPNERGYKDVFRVPGNQILRVMGKFDG
                     AYGRFMYHCHLLEHEDMGMMRPFVVMPKEVLEFDHGAGHGGHDGHTA"
     misc_feature    8289..8303
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.52"
                     /tool="antismash"
     gene            8432..9961
                     /locus_tag="LUX31_RS08375"
                     /old_locus_tag="LUX31_08375"
     CDS             8432..9961
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019062771.1"
                     /locus_tag="LUX31_RS08375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_08375"
                     /product="hypothetical protein"
                     /protein_id="WP_235474145.1"
                     /transl_table=11
                     /translation="MTDHALRLLRQSRSAAELAAFPFDFDLDRADHGEEVRLASGGELT
                     PVAGDGTGGTFFVCADGSVLYAGSEGSAGIIGSSADEALEIVIGLPGWHDYLDLSPADG
                     TEKILARIAETEQEMREDSDIDAERAELRGALGLPERSPVELIGLLHKALLRTEPDFLL
                     LNAEEGGAYELLDRQPRPPLWEPVLARGRADLAVLRAGDGPVAWDEVARDPLRRRLALR
                     AAQFDRADGDLGLLRHLVRYEAESSMTDELRLGAVLVGLQGLAEDLPLLHEVRDTDFDT
                     ACGLSELPGSGAMGAELRQWALDMDASMFGTDPSDEPLFTWTELARDQGMTELARVALI
                     RLLDEVELGLYQLGRPGKSPEALDTSPLRALSHEFQGLGDRFQALRAQRLLAGLPDTAW
                     ARVSARLTQARLERELGQLPQATATLAALRAILTDPRDTSLRLWHGVNLGRYITEEHYA
                     LTRALADADLPEEARALLASADAILGELSGNAATGVRELAEETAERVRDLG"
     gene            complement(10001..12157)
                     /gene="cyc2"
                     /locus_tag="LUX31_RS08380"
                     /old_locus_tag="LUX31_08380"
     CDS             complement(10001..12157)
                     /EC_number="4.1.99.16"
                     /EC_number="4.2.3.22"
                     /EC_number="4.2.3.75"
                     /codon_start=1
                     /gene="cyc2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020133697.1"
                     /locus_tag="LUX31_RS08380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_08380"
                     /product="germacradienol/geosmin synthase Cyc2"
                     /protein_id="WP_235474146.1"
                     /sec_met_domain="T1TS (E-value: 4e-80, bitscore: 269.1,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQPFVLPHFYMPYPARLNPHLDEARAHSTVWAREMGMLEGSGVW
                     EQSDLDAHDYGLLCAYTHPDCDGPDLSLITDWYVWVFFFDDHFLEVFKRSQDRDGGKAY
                     LDRLPLFMPLDLSTPVPEPQNPVEAGLADLWARTVPSMSVDWRRRFSVATEHLLNESMW
                     ELSNINEGRISNPVEYIEMRRKVGGAPWSAGLVEYATAEVPASVAESRPLRVLMETFSD
                     GVHLRNDLFSYQREVEDEGELSNGVLVLETFFGCTTQEAADTVNDILTSRLHQFEHTAL
                     TEVPGLALEKGLTPDQVAAVAAYTRGLQDWQSGGHEWHLRSSRYMNEGALEESRPFGVG
                     AFGTSATNIGALLASAGAERLRAYTHVPYQQVGPSQLPDFYMPFRLTLSPHLDGARYRL
                     TDWMHSMGMLQEGVWDEDKLAAADLPLCAAGIHPDATADALDLSSAWLSWGTYGDDYYP
                     LVFGHRRDLAAARLCTERLSACMPIEGDAFPAPVNGMERGLIDLWRRTTVEMTPDQRRT
                     FRAAVDVMTESWVWELSNMTQNRIPDPIDYLEMRRATFGSDLTMSLCRIGHGRTVPPEV
                     YRSGPVQSLEKAASDYAMLINDVFSYQKEIQYEGEIHNGILVVQNFFDCDYPTALGIIH
                     DLMTQRMQQFEHVAAHEFPVLYEDFKLTDEARAIMDGYVDELRNWLSGILHWHQQVPRY
                     KADYLARRSHGFLPDRSSSVLAVG"
     gene            complement(12305..13069)
                     /locus_tag="LUX31_RS08385"
                     /old_locus_tag="LUX31_08385"
     CDS             complement(12305..13069)
                     /EC_number="7.6.2.14"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058063.1"
                     /locus_tag="LUX31_RS08385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_08385"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_235474147.1"
                     /transl_table=11
                     /translation="MLTLDSLGQHYGDHSVLRDISLTVPDGQLLCVVGPSGCGKSTLLR
                     TIAGLLPAHEGTVTVDDTPVSGVPDRLAVVFQDYGRSLFPWLTVRENVALPLRRRGLGR
                     AERRGEAERILERVGLAGAARRHPWQLSGGMQQRVAIARALVCRPSLLLMDEPFGSLDA
                     QTREDLEDLLLEVHRTDGATIVFVTHDIDESVYVGDRVVVLSPGPGSRVLLDLPVGLPG
                     PRDQIGTRGLPEFVALRAQVGRAVRSGAGEGS"
     cand_cluster    12979..23875
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    12979..23875
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[17978:18875](-)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(17979..18875)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="2"
     misc_feature    complement(13044..13058)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     gene            complement(13102..14010)
                     /locus_tag="LUX31_RS08390"
                     /old_locus_tag="LUX31_08390"
     CDS             complement(13102..14010)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019071443.1"
                     /locus_tag="LUX31_RS08390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_08390"
                     /product="ABC transporter permease"
                     /protein_id="WP_235474148.1"
                     /transl_table=11
                     /translation="MSGRTGPTADKPPRADTAQKKTGTAGTGSASPTLIASRTARVGSR
                     ARGALLRWLVLALAVGVWQLAARAHGSVYFPPPGRIARHAYDLWFSGPVSHLFLTDAAV
                     DNILPSLGRMAVGFALAAVAGVALGIAVGRSRRAYALCNPVLQFARAVPPPALVPVFVV
                     VLDFGTQMQIASIVFSAVWPVLINTADGARNVDPLRLEVATVLRLTAFERLWLLLLPSA
                     LPRIFAGLRLSLSLSLILMVFSELLPGTANGIGFTLTDAQSRSDLLTVWAALVLLGALG
                     HLLNTGLLAVEKRLIGSKRPT"
     gene            complement(14007..14912)
                     /locus_tag="LUX31_RS08395"
                     /old_locus_tag="LUX31_08395"
     CDS             complement(14007..14912)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431982.1"
                     /locus_tag="LUX31_RS08395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_08395"
                     /product="ABC transporter permease"
                     /protein_id="WP_235474149.1"
                     /transl_table=11
                     /translation="MKRVRERAQVRELGRGRVRVRQEPVLGVLGVLLAFGVCEAVSRAG
                     IVRRSYLPPASEVLARAVELAGDRAFLDGLGATLRAWALGLGLACAIAIPLGLLLGSVP
                     VVDAAVRAIVEFLRPMPSVALIPLVSLLLGSGTETKVALITYASVWPILFNTVYGLGET
                     DPLAKDTLRAFGFGRLSVLLHVELPGTAPFIAAGIRISAAIALILAVATEILAGFGEGL
                     GIFIAQAGTATDGTRDVLAGVMWAGTLGLVIDGVLVRCERRAFPWTPEHRPRERQARPA
                     SASVRGERSATDVSDHEVHP"
     gene            complement(14909..15838)
                     /locus_tag="LUX31_RS08400"
                     /old_locus_tag="LUX31_08400"
     CDS             complement(14909..15838)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019071441.1"
                     /locus_tag="LUX31_RS08400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_08400"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_235474150.1"
                     /transl_table=11
                     /translation="MLAALTLAVAACGGDGSDSSSSDDGKERIDVAALPLIDCVALYIA
                     RDRGLFEKEGLDVRITQVQQSLQALPALAKGQVDVVASANYVTYLQAHEKGTLDIRIVA
                     ESIRAAPRMMDVLVSKDSDIETVADLKGRKVAVNVLNNVQSLTFNEILEQAGAGLPEYR
                     QVPFPQMGAALEKGQVDAIHVVEPFDSVIQDELKARVLIDGSSPPVETIPLSGYVTTNQ
                     YATENPETLAAFQRAIKAAAQIAGEDPSAVRAVVPTYTKVTADQANSIDLPVFPPVMDA
                     TQIARLTELMEKQGLLKKAIDPATLLVR"
     gene            complement(15942..17138)
                     /locus_tag="LUX31_RS08405"
                     /old_locus_tag="LUX31_08405"
     CDS             complement(15942..17138)
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006381323.1"
                     /locus_tag="LUX31_RS08405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_08405"
                     /product="damage-control phosphatase ARMT1 family protein"
                     /protein_id="WP_235474151.1"
                     /transl_table=11
                     /translation="MPVSDSVSPPVILSNEPGSFPWSVLAERHPALIQKVRDAFPYGPE
                     QHRALDALLKNCTEGAVEPLPAGAEDREQWEEWGTREYAGRSWFDVPWLWAEGYFYRQL
                     LEAVGYFGGDGGAGAWRGIDPFRPFKLAELDAPETDEELAALDDLVGRPEEEQARALLH
                     GSLWGNRADLGFRLSGADEGGEAAGLVADDSESLWSLLRPTRRDAGTVCLVADNAGREL
                     VPDLLLLDHLLTRGYAERAVLHVKPHPFFVSDATTADVVDALRRLTRAPGEAAAYGHRL
                     WSAMADGRLTVRAHPFSCAPLPYAEMPDDLREDFASATVTVMKGDLNYRRLVGDRLRPP
                     TTPFADVTEYFPGPVAALRTLKSDVIVGLDARTETALVAAEGQRWRTSGTRAVVQVAR"
     gene            complement(17253..17903)
                     /locus_tag="LUX31_RS08410"
                     /old_locus_tag="LUX31_08410"
     CDS             complement(17253..17903)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657051.1"
                     /locus_tag="LUX31_RS08410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_08410"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_235474152.1"
                     /transl_table=11
                     /translation="MARQLRAEQTRATIITAAADLFDRHGYESTSLSDIVEHAHVTKGA
                     LYFHFAAKEDLAHAILEIQSRTSRRMARDIEGRGYSSLEALIRITFGITRMAVEGPISR
                     AGLRLAAGDVVVRPPLRHPFREWSEIASGKLLGAVKESDVHPDIDVDAMAHSLVSFFVG
                     SRVVSRAVEPVARQPRRTADMWRLTIRALVPTPRRARYLSLVAQLEREIRVVA"
     misc_feature    complement(17889..17891)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(17979..18875)
                     /locus_tag="LUX31_RS08415"
                     /old_locus_tag="LUX31_08415"
     CDS             complement(17979..18875)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657052.1"
                     /locus_tag="LUX31_RS08415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_08415"
                     /product="ScbA/BarX family gamma-butyrolactone biosynthesis
                     protein"
                     /protein_id="WP_235474153.1"
                     /sec_met_domain="AfsA (E-value: 4.8e-23, bitscore: 79.8,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTASVPRQLVHRAAIAETFPTGWSRTETDRFSVSAQWPRVHCLHV
                     SADRTAYDPLLVVETVRQAGTLLNHTEYQVPLDHQFVLQEFRITTFPEHLGVGPVPAEP
                     TVDITFSDIRHRGKRLVSARYAADVLLDGELVAHADVAFTCTSGAVFSRLRGGRTAAGV
                     TALPVPPGLPAADVGRDSAADVVLAPPQQDDRDWQLRVDTGHAVFFDHPLDHIPGMLLL
                     EAARQAALARTGPDGGLIPVSFDTTFHQFAELDLPTWIESTDQGDGALKVVGTQEGHTV
                     FECVVGTMERSAILYRQ"
     misc_feature    complement(18747..18749)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            19136..19795
                     /locus_tag="LUX31_RS08420"
                     /old_locus_tag="LUX31_08420"
     CDS             19136..19795
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006381293.1"
                     /locus_tag="LUX31_RS08420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_08420"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_235474154.1"
                     /transl_table=11
                     /translation="MAKQERAIRTRRAILEAAGAVFDEHGYTSTTIAMVLERAEVTKGA
                     LYFHFPSKESLAQAVLDEQVPFGTVPEQPCKLQEIIDMTFVVAQRLLTDSLLRGSVRLT
                     VDQATPPGVDHSGPFRQWGERLIVLMEQAGAQGELLPTVKPQDTVELLVGGFAGIQLMS
                     RALTDRADLAHRISVLWSHILPGIAVPGLLLGLDSRADRGVRILSPAPAPVPVPVP"
     gene            19792..20643
                     /locus_tag="LUX31_RS08425"
                     /old_locus_tag="LUX31_08425"
     CDS             19792..20643
                     /EC_number="1.6.5.2"
                     /GO_function="GO:0016655 - oxidoreductase activity, acting
                     on NAD(P)H, quinone or similar compound as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006381310.1"
                     /locus_tag="LUX31_RS08425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_08425"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_235474155.1"
                     /transl_table=11
                     /translation="MILLTGATGTVGRLVAERLAGTGPLRLLTRDPHRVTLAGPGVEVV
                     RGDFDDAAGLRTALAGVRSALLVTANPLAPAQDENFVAASRAAGVPQVVKLSAQAVTDP
                     GATDLITRWQRCNEELLRASGLAWTLLRPRAFMSNTLGWARSVREEGVVRGPYGTSRNA
                     NVDPRDIADVAVRALTDPEAHAGRAYALTGPAGVTPVEQTEILGELLQRPLKFVELTED
                     EVLRGLLARYPEAVAHALVESAARGRDGAKGQVEPDVAELLGRPGRSYREWAAEHLAEF
                     SG"
     gene            complement(20910..22706)
                     /locus_tag="LUX31_RS08430"
                     /old_locus_tag="LUX31_08430"
     CDS             complement(20910..22706)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020122073.1"
                     /locus_tag="LUX31_RS08430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LUX31_08430"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_235474156.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 4e-51, bitscore:
                     172.8, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTSPTRATGRKLISAAAVSAALVAAATTSVAFAQEPAAPATAPE
                     AAAQAVAVPAERLIVGYKAGAAEARSNQAADADAVAKGKEAGESLDFQRRLGTGAALVD
                     LGEQLSKADVADVIAEYQADPQVAYVVPDRLNKPQADPNDTEYSKQWDLFETTAGMRVP
                     DAWTTATGTGVTVAVIDTGYVTHSDLAANIVAGYDFISDTAVSVDGNGRDSNPADPGDW
                     YATDECGTGTGSSNSSWHGTHVAGTIAAATNNSKGVAGIAYNAKISPLRVLGKCGGYDS
                     DIIDAITWASGGTVSGVPANANVAKVINMSLGGSGACTTATQTAITNAVGRGTTVVVAA
                     GNSNANAANYSPASCSNVISVAALSRTGAKASYSNYGSTVDIAAPGGQTSTGTANGILS
                     TLNSGTQGPSTESYAYYQGTSMAAPHIAGLAALMKSANSSLTPAQIESAIKTNSRALPG
                     ACSGGCGAGLADATKTVQAVSGTTTGTTFSSTTAVSIPDNSSAVESSIAVSGRTGNAPS
                     ALQVGVDITHTYRGDLVITLVAPDGTTYPLKASSTSDSADNVSATYTVDASSEVANGTW
                     KLRVQDVAASDTGTINSWKLTF"
     misc_feature    22868..22884
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.75"
                     /tool="antismash"
     misc_feature    23228..23241
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.82"
                     /tool="antismash"
     misc_feature    complement(23644..23659)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.85"
                     /tool="antismash"
     misc_feature    complement(23745..23763)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.75"
                     /tool="antismash"
ORIGIN
        1 gcgtggacgc gcgagaccgt ctcgtgggtg agccgcagac cgttggccgg gtcgcgccct
       61 atgcgcaacg ggtggccgct gccggggtgg ggcagcagca gcttggggag ccgctcggac
      121 tgccaggccc tgcgcagccg taccgtgaag ccggagaccg cctcgaccgt cccgaacacc
      181 aggcgggaca ggcggctctc ggtgggcaga tccgcggtga ggacggccag ttcgtcggac
      241 cggcgggcga tgagggcgag ttccatccgg cggatgaacg tgtcgtgcga cagccggccc
      301 agggcgaccc cgtcccgcag caccttcagc gcccggtcgc gctccgcgtc ggagagacga
      361 gccggatacg tgtggaactc gaaggacgac gtcacgttcg tgattgtcgg gcagcgcgcg
      421 cggagtgtcc agaaaacgcg gaaacggtgg cccgtcggtc cggcccgacg acacccgggg
      481 caaacgtgaa gattcaagcg cggagcgggg tgtttgaagc acgatgggac gggctacctc
      541 ccgggcacca cccggcagac gaaggggaac cgtccgtgca cttcgaggtg tgggcaccgc
      601 aggccagtcg tgtgacgctc cagtgcgacg cgggcacgcg cgcgttggag cgcgatccgg
      661 agcgcgcggg ctggtggtcc ggcgaggccg aggcccggga agggtcgcgt tacggcttcg
      721 ccgtggacga cggccccgta ctgcccgacc cgcgttcgcg ccgccagccg gacggcccgg
      781 acgggctgag cgcggtcgtc gaccacgggc tccacacctg gcgcaccgag tgggcgggcc
      841 gggcgctgcc gggcgcggtc ctgtacgagc tgcacgtggg cacgtacacg cccgagggca
      901 cgctggacgc ggcggccggg cggctcggcc acctggtcga actgggcgtg acgcacgtcg
      961 agttgatgcc gctgtgcccg ttcccggggc ggcacggctg ggggtacgag ggggtctcgc
     1021 tgtgggcggt gcacgagccg tacggcggcc ccgaggcgct gaagcgattt gtcgacgagg
     1081 cgcacgcgct cggtctcggt gtggtcctgg acgtcgtgca caaccacttg ggcccttccg
     1141 gcaactatct gcccgccttc ggcccgtact tcacggacac gcaccagacg ccgtggggtt
     1201 ccgccgtgaa cctggacgcg cccgggtcgg acgaggtgcg cgcgtatctg ctgggcagcg
     1261 cgctggcctg gctgcgcgac taccgggtcg acgggctgcg gctggacgcg gtgcacgcac
     1321 tgcgggacac gcgcgcgtgc cacttcctgg aggagctgtc gacggctgtg gacgccctcg
     1381 ccgccgagct gggccggccg ctgtccctga tcgccgagtc cgacctcaac gacccgcggc
     1441 tcgtcacccc gcgcgcgggc ggcggcctcg gactgcacgc ccaatggagc gacgacttcc
     1501 accacgccct gcacaccgca ctgaccggtg agtcgaaggg ctactacgag gacttcgcgc
     1561 gggccccgtt cgcggcgctc gccaagacgc tcacgggcgg ctacttccac gacggcacgt
     1621 actcgacctt ccggggccgg ctgcacggcc gcccgctcga ccgcacccgg gtcgccgcgc
     1681 accggctgct cggcttcaca cagacccacg accagatcgg caaccgcgcc cagggggacc
     1741 gcctttcggc ctccctctcc cccggtctgc tggcctgcgg ggccgcgctg atgctcaccg
     1801 ggccgttcac gccgatgctg ttcatgggcg aggagtgggc ggcgggcact ccgtggcagt
     1861 tcttcaccga ccacacggac gcggacctcg cggaggccgt acggcggggc aggcggcggg
     1921 agttcacggc gcacggctgg gccgaggagg acgttcccga cccacaggac ccggcgaccc
     1981 gcgaccgctc ctgcctcgac tggtccgagc ccggacgtga gccccacgcg cgcgtgctgt
     2041 cctggtaccg cgagctgatc gccctgcgcc acgcccagcc cgacctcacg gaccccgacc
     2101 tgtcggacat caaggtcgcg tacgacgagg aggcccgctg gctcgccttc cggcgcgggg
     2161 acgtacgcgt ggtggcgaac ctggcagcga agccggcggc ggtccccctg ggcccgcgac
     2221 aggcaacggt gctggccgcc tgggagccag tcgaactgcc gggcgcggac ggactgctgc
     2281 acatcccagg ggagtcctgc gtggtgctgg agcaagggtg agttgtcttg tggggcagcg
     2341 acggtacctg cctgagcggc agcgacgttc ctgtccggga gatcggttcc cgcgctgtcg
     2401 gtgccccctt gcgggcgcca ggcctaccct tcctcgtcct gctcccgcag ttccgtcacc
     2461 cgttccagca ggatcgcctc ccacgcgcgc cgcagctgca cccgcagcag cggtcgcggg
     2521 ccggcgtcgc ggccggtgag gctctcggcg agccggacga tcgtgtcgca gcgggcgagc
     2581 cacaggccgc gcagacaggg gcgggccgcg taaccggcga gggtggccgc gcgtacggcg
     2641 gcgggcgagc cgaccgcgag ggcgagcccg gcgatgtcct cggccgggtc gccgacgacc
     2701 gcgtcggccc agtcgaggac accgcgcacc cgcccgtcgg cgctcaccac gaggtgctcg
     2761 cccctcagat cgtggtggac gaggaccgcc gtaccggcct gcgcggcgag ttgcgtggcg
     2821 gcggccgggg tgagctggtg gagccgtgcg gggtcgaact cgtcggccgc ggcgagacgt
     2881 tcggccgcgc gctcggcggc ccggcgcagg gcctccaggg agcgtggcgc gacccgtggc
     2941 accccgagcg tctcggcctg ccgtgcaggc acctcgcgca ggcccgtgag cagcgcggcc
     3001 agatcggcct cgccgacggc ggagacgtcg tgctcctcgg ccgagccgcc gggcaccctg
     3061 gtgtccagcg tgtaggccag tccggcggcc cactcgccgt gcgccacacc gacggggacg
     3121 gcgacgccga ggtgcgggcg cacgaggtcg cgcaggcgca gttcgcggcg cagccgcgcg
     3181 gacgcgtccc ggtcgggggc caggcgcagg acgtgccggg caccgaccca ccaggtggac
     3241 gcctcgccgc ccgcgccgac gggccgcacg tcgggtcccg ccgtggcgga cgtgccgagg
     3301 gcgctgtccg cgagcaggga gcggaccagt cggcggaccg tgtccgcggt gggtgtcggt
     3361 gcctgtgtca tggtcgcgcc gttgtcgtcc ggaggggtgc tggcagggcg gaactcctgg
     3421 tgagcggtcg gtcagtccac gacgaccagc tcgcgcgtcg tgttgttgag gcgtcggccg
     3481 ccgtcctcgg tcaccgtgac gatgtcctcg atgcgtacgc cgaagcggcc gggcaggtag
     3541 atgccgggtt ccacggagaa gcacatgccg gggacgaggg gccgttcctc gccctcgatc
     3601 atgtacggcg gctcgtgcgt ggtgacgccg atgccgtggc cggtgcggtg gatgaagtac
     3661 tcgccgtatc cggcctcggt gatgaccgcg cgggccgccc ggtcgacgtc ctggcacgcc
     3721 gcgccgggcc gcacggcgcg gaagcccgcc tcctgggcct cgcgcacgat gtcgtggacc
     3781 ctgcgccgct cggcgtccgg ttcgccgacg tggaccgtgc gggaggtgtc ggagccgtag
     3841 ccgtgcagga ggccgccgaa gtcgaggacg accatgtcac cccgctcgat gacgcggtcg
     3901 ccggcctcgt ggtgcgggtt ggcgccgttg gggccggagg cgacgatcgt gaagtcgacc
     3961 tcggagtgcc cgaaccgccg cagcagatcg gcgagatcgc ccgcgacgtc cctctcgcgg
     4021 cggcccccga agggaacctt ccggatctcc tcgtacgttg cgtcagcagc cgctcccgcg
     4081 gctgccaggc gtgtcagttc cgccgcgtcc ttcacggcgc gcagcatcgg cagtccctcg
     4141 gtgagggaga cgtacgaggt gccgggcagc gccttctgga gtgccagcag atgcagtgcc
     4201 caggcgttgt cgctgacccc gaagcggccc gccgcgtcga ggaggggtgc ggtggccgcg
     4261 tacgggtcct tgccgtcggt ccagtcgcgc agggtcaggg cgggtgcgcc cgccgcgtgg
     4321 gccgcgtccg gggcctccag ggcggggacg acgaggaccg ggtcctgtcc ggcggccagg
     4381 acgagcagag tgaggcgttc ggtgaccgcg gtgggtgcgt agccggtgag ccagacgagg
     4441 tcgggtcctg gggccaccag gagcccggcg agccccgcgt cctcggcctc ccgtgcggcg
     4501 cgccgcatcc gggcccggta gtcgtcggcg gtgaagggcg cggggctgct gccggtcatc
     4561 cgggcctccg tggaagggcg aggggctacg ggcagcatcc tgcccggatg cgcggggcgg
     4621 cgcgagccgg tttgcagctc tcaccacccg tctcgcgtcc atctcccacc cgctccctcc
     4681 caccgcggcc cactcaacta acggatgaga gttgagcaac cattagatct aatgcttaga
     4741 tctacctgaa ccattaaggg aggcggaagt ccatgctcgt actggcccac atcagcgatc
     4801 tgcacctcga cggaaccgcg cggtccatcg cacgcgccga acgggtgcgc gaccggctgt
     4861 gggagctgcc ggggcatgtg gacgccttgc tggtgaccgg ggacatcgcg gaccacggca
     4921 cggaggccga gtacgaggag gccgcgcgca tcctcgggct gcgcaccggc gacgcgccct
     4981 tccccgtact cacctgcccg ggcaaccacg acagccgcgc gccctaccgc aaggcgctgc
     5041 tcgggctgcc cgccgccgag gggccggtga acagcgcgca cgtcttcgac gacgccgccg
     5101 tactgatgtg cgactccagc gtgccgggcc gcgacgaagg cgccctcgac gacgagacgt
     5161 acgactggat cgacgcgacg ctcgacgaac tggacgaggg cgtcccggcg ctgctcgcct
     5221 tccaccaccc gcccgtcgcc ctgcaccacc ccctgccgga ctcctaccag ctgggccggc
     5281 ccgaccggct ggccgccctg atggagcgca gcccgcagat cgccggtctc atcaccggtc
     5341 acgcgcacac cccggccgcc acgaccttcg cgggccggcc gctggtcgtc ggcccggggg
     5401 tgacgtggac cctccagctg ccctgggagg gcgaggaggt cgcggaccgg gacgcgccgg
     5461 tcggcctcgc ctttcatgtg ctggccgacg acgggcggct gaccagccac ttcagggtgg
     5521 ttgtctgacg gagggtcgtc aggtggcgga cgcggtcggg tgacggaggc cgtccactga
     5581 ccgaggcggt caggtgacga cgcccgggat cgccaccaac tgctggtagc cgccgctgcg
     5641 gtgacggacc gtgagggtga tctccgcacc ggggcgggca cgggcgacca cacgggcgag
     5701 atcggccgcc gagtcgaccc gggccccgcc gaaggtgagg agtacgtcgc cccggaccag
     5761 gcccgcggtg tagccggggc ccgggatgtg gacgccgacg accagggctc ccactttctc
     5821 ggcgtccacg gcctcgacac cgagcgtcgc ggtcacggcc gacgccgagg aggccgggct
     5881 cgcaccgtcc gagggctgcc tggagtggcc cgacccggat cccggcccgg accgggactc
     5941 ggccccggac ccaggccctg actcggcggg cgcaccactt cgcgcgcccg ccgagtcagg
     6001 cccctgcccc tgaccctgtt gccctgcctg cccgtcctgt cccgcctgac gctgcaggtc
     6061 cgcgagcttg ctcatgccga tcaccgtggc gccgagcgtg ccgagcccga cgcccgcgag
     6121 gaccaggacg gccccgacga acaggccgaa cagcagggcc gtcagccgtc ggccgcgccg
     6181 gggcgcggca tgcgggcgcc gggccggacg ggttgtggtg ccgccggccg gttcctgacc
     6241 gggcatgggc ttgggacgca gtgcggtctg ttccatggtt cgcctccggc aggtgctcta
     6301 cccggcgcac cggcgcacaa cgagccacga acgagtgaga ctgacacagg gtcagaaatg
     6361 ggcagccata ggcgtccgcc cggacccctc aggccgtgtg accgtcgtgg ccgccgtgtc
     6421 ccgccccgtg gtcgaactcg agcacctcct tgggcatcac cacgaagggc cgcatcatgc
     6481 ccatgtcctc gtgttcgagg aggtggcagt ggtacatgaa ccggccgtac gcaccgtcga
     6541 acttccccat gacgcgcagg atctggttcc cagggacccg gaagacatcc ttgtagccgc
     6601 gctcgttggg cgccagcggt atctgtgtgg ccgcgtcgaa ggcgatcggg ctccgggtgc
     6661 cgccgaccgc cgggtcgaag cccgagacgt tgtaggcgtc ccggcccagg agctggaagt
     6721 cggccaggtg gatgtgcatc gggtggacga tcggggagag gttgaggaag ctccactgtt
     6781 cgtggctgcc ctcggcgatg gtgaagccga ggccgtcgtt gaacgtccgt gccgtacggc
     6841 ggtacgtctt ggtcgttccg tcctggccgg tcacctggat gacgccctcg gcggggaact
     6901 ggatgccggt cgggtcggcg acctcggtca tctcccagat ctccgggtgt ccgccgccgc
     6961 ccttggtggc gggcggggtg aggacgatca tccggtgccc gtgctcgatg ccgtgcgtga
     7021 ggcggcggaa ggagccggag agcacctcgg gcagttcgaa gctgtcgctg acgcactcct
     7081 cgcgcacccg gaactccatg acctccgggt agcgcacgtc gctcgccggg tcgggcacgc
     7141 ccggtgcctg ggcgcggccc ttgttgacca ggcgcagctt ccggccggcg agccccctga
     7201 agtcgacgag caggtcgaaa cgctcggccg gggcggcggt cagcgtgggc agcgccccgt
     7261 cgaagtcgac ggggacgggg cgcggcagca gtccgccgtc gctgccgatc tggtggacga
     7321 cgcccgggac cgggttgttg tcctcgtcga ccaggacgag gttgtagatg cgcgcgttgg
     7381 acgcgttgac cagccggaag cggtaccagg cggcgtccac gtcggcgtac ggccagatac
     7441 ggccgttgac cgtggtgtac gggccggtga acgggatgga gaccggcttg agcgtctccg
     7501 ggttctgctg ctgcacgatg acggtcttgt gcaggagacg tccgttgaga cggccgtcct
     7561 cgtccgtgtc caggttccgg tcggcgagca gcagcggtat ctcccgctcc ccgcagggga
     7621 gatggagggc gtcctcctcg tcgtcacgga cgaggtaggt gccgtagagg cccgccagca
     7681 cgttccaccg ggtgatgttc atggcgtggt cgtggtacca ccactggacc gcctggtggt
     7741 cgttcggata ctcggagagc tgggcgtcgc cgaagcccac ggcgttgtcc gcccagccgt
     7801 cgttgccgcc gcccgtctgg gcgccgtgca gatgggtcac cgaccaggcg ggcagggccg
     7861 ccacgtcctt gttgggctcg acgccctcgc ggcccggttc ggtggtcgcc ggcggggtcc
     7921 ccggtgcgcg gaccgggacc tccacggcgg tgaccgggta ttcgccgtcc gcgggaatgc
     7981 ggttggtcca ggcgatccgg acgcgctgtc cgcggcgcac ctcgatggtc gggccgggca
     8041 cctgtccctc gtacccccac atcagggtcg gcggcagctg cgggtgcagg cgcacccagg
     8101 ccgggcgcag ggcgatctcg gtctccttca gcacgtcctc ggacgcgggc cgcaggaccg
     8161 gagggacgag cagcggcgcc acgtacggcg tcaactcccc gggcgcgggc gcctgttccc
     8221 ctgtaatgct ttccgtaggc ctctcaatga tgtcggtcaa ggtcgaacac ccccgtgttc
     8281 tggtggtctg tcattcagtt ccactcacct cataagactc ctggcgaatt gccgaagttc
     8341 cctgaatgtg cggttccgta cgagaaggtt cggaaactgg taatggacgg cgatattccc
     8401 gttgtcagtg ggggctgtta cgttctgcgg catgaccgat cacgccctgc ggctgctgcg
     8461 acagagccgt tccgccgccg aactggccgc gttccccttc gacttcgacc tcgaccgcgc
     8521 cgaccacggg gaggaggtcc gcctcgcctc gggcggagag ctgaccccgg tggccggcga
     8581 cggcacggga ggcacgttct tcgtgtgcgc ggacggatcg gtgctgtacg ccggctcgga
     8641 gggctcggcc gggatcatcg gctccagtgc cgacgaggcg ctggagatcg tgatcggtct
     8701 gcccggctgg cacgactacc tggacctgtc gcccgccgac ggtacggaga agatcctcgc
     8761 gcgcatagcg gagacggagc aggagatgcg cgaggactcc gacatcgatg ccgaacgcgc
     8821 cgaactgcgc ggcgccctgg gactgcctga gcgctccccc gtggagctga tcggcctgct
     8881 gcacaaggcg ctgctgcgca ccgagcccga cttcctgctg ctcaacgcgg aggagggcgg
     8941 ggcgtacgag ctgctcgacc ggcagccgcg cccgcccctg tgggagccgg tgctcgctcg
     9001 tggccgggcc gacctggccg tgctgcgggc gggcgacggc ccggtggcgt gggatgaggt
     9061 ggcccgggat ccgctgcgcc gccgactcgc cctgcgggcc gcgcagttcg accgcgcgga
     9121 cggcgatctg ggcctgctgc ggcatctcgt gcggtacgag gcggagtcgt cgatgacgga
     9181 cgaactgcgc ctcggtgccg tcctggtggg cctgcaagga ctggccgagg atctgccgct
     9241 gctgcacgag gtccgggaca cggacttcga caccgcgtgc ggtctgagcg agctgccggg
     9301 gtccggggcc atgggtgccg aactgcggca gtgggcgctg gacatggacg cctcgatgtt
     9361 cggcacggac ccgtcggacg aaccgctgtt cacctggacg gagctggccc gcgaccaggg
     9421 catgaccgaa ctggcccggg tcgcactgat ccgcttgctg gacgaggtcg agttggggct
     9481 gtatcagctc gggcggccgg gcaagtcacc ggaggccctg gacacctcgc cgttgcgggc
     9541 gctgagccac gagttccagg gactgggcga caggttccag gccttgcggg cccagcgtct
     9601 gctcgccggc ctcccggaca cggcctgggc ccgggtgtcg gcccggctga cacaggcccg
     9661 cctcgaacgg gagctggggc aactgcccca ggccacggcc acgttggcgg ccctgcgggc
     9721 catcctcacc gacccccggg acacctccct gcggctctgg cacggggtga acctcggccg
     9781 ttacatcacc gaggagcact acgccctcac ccgcgcgctg gccgacgcgg acctcccgga
     9841 ggaggcccgc gccctgttgg cctccgcgga cgcgatactc ggcgagctct cggggaacgc
     9901 cgccacgggc gtacgagaac tcgccgagga gacggcggaa cgggtgcgcg acctcggctg
     9961 acggaggacg ggcgcgtacg tactggtggg cggggagccg tcagccaacc gccagtaccg
    10021 agctgctgcg gtccggcagg aagccgtgcg acctgcgggc caggtagtcc gccttgtagc
    10081 ggggcacctg ctggtgccag tgcaggatgc cggacagcca gttccgcagc tcgtccacat
    10141 agccgtccat gatcgcgcgt gcctcgtccg tgagcttgaa gtcctcgtac aggaccggga
    10201 attcatgggc ggcgacatgc tcgaactgct gcatgcgctg ggtcatcaga tcgtggatga
    10261 tgccgagcgc ggtcgggtag tcgcagtcga agaagttctg gacgacgagg atgccgttgt
    10321 ggatctcgcc ctcgtactgg atctccttct ggtacgagaa gacgtcgttg atgagcatcg
    10381 cgtagtcgga ggccgccttc tccagcgact ggacggggcc gctgcggtag acctccggcg
    10441 ggaccgtccg gccgtggccg atgcggcaca ggctcatggt gaggtccgag ccgaaggtgg
    10501 cgcggcgcat ctccaggtag tcgatcgggt cggggatgcg gttctgggtc atgttggaca
    10561 gttcccacac ccagctctcg gtcatgacgt ccaccgcggc acggaacgtg cgccgctgat
    10621 cgggggtcat ctcgaccgtc gtacgccgcc acaggtcgat gagcccgcgt tccatgccgt
    10681 tgaccggggc agggaacgcg tcgccctcga tgggcatgca ggcggagagc cgctcggtgc
    10741 acagacgggc cgcggccagg tcgcggcggt ggccgaagac gagggggtag tagtcgtcgc
    10801 cgtaggtgcc ccaggacagc caggcggagc tgaggtcgag ggcgtcggcc gtcgcgtccg
    10861 ggtggatgcc ggccgcgcac agcggcaggt cggcggcggc gagcttgtcc tcgtcccaga
    10921 cgccttcctg gagcatgccc atgctgtgca tccagtcggt gaggcggtac cgggcgccgt
    10981 ccagatgcgg gctgagggtg agccggaacg gcatgtagaa atccggcagt tgggacgggc
    11041 cgacctgctg gtagggcaca tgcgtgtagg cgcgcaggcg ttccgcgcct gccgaggcca
    11101 gcagtgcgcc gatgttggtc gcggacgtgc cgaaagcgcc gaccccgaac ggccgcgact
    11161 cctccagggc cccttcgttc atgtaccggc tggagcgcag atgccactcg tggccgccgg
    11221 actgccagtc ctgcagcccg cgcgtgtacg cggccaccgc ggcgacctgg tccggtgtga
    11281 ggcccttctc cagggccagg ccggggactt cggtgagcgc ggtgtgctcg aactggtgca
    11341 gccgtgaagt gaggatgtcg ttgacggtgt cggcggcctc ctgggtcgtg cacccgaaga
    11401 aggtctccag gacgagtacg ccgttgctca gttcgccctc gtcctcgacc tcccgctggt
    11461 aggagaaaag gtcgttgcgc aggtggacgc cgtccgagaa ggtctccatc aacaccctga
    11521 gcggcctcga ctccgcgacg gacgcgggca cttcggcggt cgcgtactcc acgagccccg
    11581 ccgaccaggg cgcgccgccg accttgcggc gcatctcgat gtactcgacg gggttggaga
    11641 tccgaccctc gttgatgttg gacagttccc acatcgactc gttcagcaga tgctcggtgg
    11701 cgacggagaa ccgcctgcgc cagtccacgg acatcgacgg aacggtgcgt gcccagaggt
    11761 cggcgaggcc cgcctccacc ggattctgcg gctccggtac gggagtcgag aggtcgagcg
    11821 gcatgaaaag gggcagccgg tcgagatagg ccttgccgcc gtcccggtcc tggctgcgtt
    11881 tgaagacctc caggaagtgg tcgtcgaaga agaagaccca cacgtaccag tcggtgatga
    11941 gcgagaggtc gggcccgtcg cagtcggggt gcgtgtacgc gcacagcaac ccgtagtcgt
    12001 gcgcgtcgag gtcggactgc tcccagacgc ctgagccctc cagcattccc atctcccgtg
    12061 cccagacggt cgaatgggcg cgcgcctcgt cgagatgcgg attcaggcgc gcgggatacg
    12121 gcatatagaa gtgcgggagt acgaacggct gtgtcatggg cggggcctta cccctgcccc
    12181 ggacgtgcca tccacggagc gggacaagat cacaccatcg cgtgaatcag gaccgattcc
    12241 gggattccgg acgggtgctg tgagttcact cgacatgcga acactacgag actttctgcg
    12301 actgctacga gccctcaccc gcccccgagc gcaccgcccg tccgacctgc gccctcagcg
    12361 ccacgaactc gggcagcccc cgcgtcccga tctggtcgcg cgggccgggg agcccgaccg
    12421 ggaggtcgag gaggacccgg gagcctgggc ccggcgacag gacgacgacg cggtcaccga
    12481 cgtacacgct ttcgtcgatg tcgtgcgtca cgaagacgat ggtcgcgccg tccgtgcggt
    12541 gcacttcaag gagcaggtct tcgaggtcct cccgggtctg ggcgtccaag gaaccgaagg
    12601 gctcgtccat gaggagcaga gaaggacggc agacgagggc gcgggcgatg gcgacgcgct
    12661 gctgcatacc gccggagagc tgccaggggt ggcggcgggc ggcaccggcc agacccacgc
    12721 gctccaggat ccgttccgcc tccccgcgtc gttcggcccg gcccagaccg cggcggcgca
    12781 gcggcagcgc gacgttctcg cgcacggtga gccaggggaa cagggagcgc ccgtagtcct
    12841 ggaacacgac ggcgagccgg tcgggcacac cggagacggg cgtgtcgtcg acggtgaccg
    12901 tgccctcgtg tgcgggcagc agtccggcga tggtgcgcag cagcgtggac ttgccgcagc
    12961 cggacgggcc gacgacgcac aggagttgac cgtcgggcac ggtgaggctg atgtcccgca
    13021 ggacgctgtg gtcgccgtag tgctggccga gggagtcgag ggtgagcatc cggatcggtc
    13081 acctgtcctg aggggctggg gtcatgtggg tcgcttgctg ccgatcagcc gcttctcgac
    13141 cgccagcagg cctgtgttga ggaggtgtcc gagggcgccg agcaggacga gggccgccca
    13201 tacggtcagc aggtcggagc gcgactgggc gtcggtgagg gtgaagccga tgccgttggc
    13261 ggtgcccggc agcagctccg agaacaccat gaggatgagg gagagcgaga ggctcagccg
    13321 aagcccggcg aagatgcgcg gcagcgcgga gggcagaagc agcagccaga gccgttcgaa
    13381 cgcggtcaga cgcagcacgg tggccacttc gagccgcagc gggtcgacat tgcgcgcccc
    13441 gtccgccgtg ttgatcagca cgggccatac ggcactgaag acgatcgacg cgatctgcat
    13501 ctgcgtaccg aagtcgagca cgacgacgaa gacgggtacg agggccgggg gcgggacggc
    13561 gcgcgcgaac tggaggaccg ggttgcacag ggcgtacgcc cggcgcgacc gcccgaccgc
    13621 gatacccagc gcaaccccgg cgacggcggc gagcgcgaac ccgacagcca tccggccgag
    13681 gctgggcagg atgttgtcga cggcggcgtc ggtgaggaag agatggctga cggggccgga
    13741 gaaccacaga tcgtaggcgt ggcgtgcgat acggccggga ggagggaagt agacgctgcc
    13801 gtgcgcacgg gcggcgagct gccagacgcc cacggcgagg gcgagcacga gccaacggag
    13861 cagcgcgcct cgggcgcggg agcccacacg ggcggtacgg gaggcgataa gggtggggga
    13921 ggcagaaccg gttccggcgg tcccggtctt cttctgggcg gtgtccgcgc gtggtggctt
    13981 gtcggccgtg ggccctgtgc ggccgctcat gggtgaacct cgtggtcgga gacgtcggtg
    14041 gcggaccgct cgccacggac cgacgcggac gcagggcgtg cttggcgctc gcgtggccgg
    14101 tgttccggtg tccacggaaa cgctctgcgt tcacaccgca cgagcacccc gtcgatgacc
    14161 aggcccaggg tcccggccca catcacacct gccaggacgt cccgggtgcc gtcggtcgcc
    14221 gtgcccgcct gggcgatgaa gatgccgagg ccctcgccga agccggcgag gatctccgtg
    14281 gcgacggcga ggatgagggc gatcgcggcc gagatgcgga taccggccgc gatgaagggt
    14341 gccgtgccgg ggagttcgac gtggagcagc acggagaggc ggccgaagcc gaaggcgcgc
    14401 agggtgtcct tggcgagggg atcggtctcg ccgagtccgt agacggtgtt gaagaggatc
    14461 ggccagaccg aggcgtaggt gatcagtgcg accttggtct cggtgcccga gccgaggagg
    14521 agggagacca gggggatcag tgcgacggac ggcatcgggc gcaggaactc gacgatcgcg
    14581 cgtacggcgg cgtcgacgac cggcacgctc ccgagcagca gccccagcgg gatcgctatc
    14641 gcgcaggcca gccccagtcc cagggcccat gcgcgcaggg tcgccccgag cccgtccaga
    14701 aaggcccggt cgcccgccaa ctccacggcc cgggccagga cttcggacgc cggcggcaga
    14761 tagctgcgcc gtacgatccc ggccctgctc accgcctcgc acaccccgaa ggcgaggagc
    14821 acgccgagaa caccgagcac cggctcctgc cgtacgcgta cccgaccccg gcccaactcc
    14881 cgcacctgtg cccgttctcg tacccgtttc accgcaccaa cagcgtcgcc ggatcgatcg
    14941 ccttcttcaa cagcccctgt ttctccatca gttcggtcag ccgggcgatc tgtgtggcgt
    15001 ccatgaccgg agggaagacc ggcaggtcga tggagttcgc ctggtccgcc gtcaccttcg
    15061 tgtacgtcgg caccactgcg cgtacggccg acgggtcctc gccggcgatc tgcgcggcgg
    15121 ccttgatggc ccgttggaaa gcggcgaggg tctccgggtt ctcggtggcg tactggttgg
    15181 tggtgacgta gccgctgagg gggatcgtct cgacgggtgg ggacgagccg tcgatgagca
    15241 cccttgcctt cagttcgtcc tggatgacgc tgtcgaaggg ctcgaccacg tggatggcgt
    15301 cgacctgccc cttctccagc gcggcaccca tctgcgggaa ggggacctgc cggtattcgg
    15361 gaagcccggc gcccgcctgc tccaggatct cgttgaaggt cagcgactgg acgttgttca
    15421 ggacgttcac ggcgaccttg cggcccttga ggtcggcgac ggtctcgatg tccgagtcct
    15481 tcgacaccag cacatccatc atgcgcggcg cggctctgat cgactcggcg acgatacgga
    15541 tgtcgagggt gcccttctca tgggcctgga ggtaggtgac gtagttcgcg ctcgcgacca
    15601 cgtcgacctg gcccttcgcc agcgcgggca gcgcctggag gctctgctgg acctgcgtga
    15661 tacggacgtc gagtccctcc ttctcgaaca gaccgcggtc gcgcgcgatg tagagcgcga
    15721 cgcagtcgat cagcggcagg gcagcgacat cgatccgttc cttgccgtcg tccgaggagg
    15781 acgagtccga gccgtcgccg ccacaggccg cgacggccag agtcagggcg gccagcaccg
    15841 ccgcgagttt tcctcttcct ggacttcccg aactttccga gcgcaatgga cgtaacgcca
    15901 tgggcgcatg cctatcaaat atttgacatg atcaccacag gtcaacgagc cacctggacc
    15961 accgcacgcg taccgctcgt ccgccagcgc tgcccttccg cggccacgag cgcggtctcg
    16021 gtacgggcgt cgaggccgac gatcacgtcc gacttcaggg tgcgcagggc ggccaccggg
    16081 ccggggaagt actcggtgac gtccgcgaac ggggtggtcg ggggccggag tcggtcaccg
    16141 accagacggc ggtagttcag gtcgcccttc atcacggtga ccgtggccga ggcgaagtcc
    16201 tcgcgcaggt cgtcgggcat ctccgcgtac gggagggggg cgcaggagaa ggggtgggcg
    16261 cgtaccgtga ggcggccgtc ggccatcgcg gaccagaggc ggtgaccgta cgcggcggcc
    16321 tcgcccggag cgcgggtcag ccggcgcagg gcgtcgacga cgtcggcggt ggtcgcgtcg
    16381 gagacgaaga acgggtgcgg tttcacgtgc aggacggcgc gttcggcgta cccccgggtc
    16441 agcaggtggt ccaggagcag tagatcgggg acgagttcac ggcccgcgtt gtccgcgacc
    16501 aggcacaccg tgccggcgtc gcgtcgggtg ggccggagca gcgaccagag ggactcgctg
    16561 tcgtctgcga cgagtcccgc cgcctctccg ccctcgtccg cgccggagag ccggaagccg
    16621 aggtcggccc ggttgcccca caacgacccg tggagcaggg cgcgcgcctg ttcctcctcc
    16681 ggcctgccca ccaggtcgtc gagcgcggcc agttcctcgt cggtctcggg ggcgtccagt
    16741 tcggcgagtt tgaaagggcg gaaggggtcg atcccacgcc aggcgccggc tcccccgtct
    16801 ccgccgaagt acccgaccgc ttcgaggagt tggcggtaga agtacccctc cgcccacagc
    16861 cacggcacgt cgaaccagga ccggcccgcg tactcccggg tcccccactc ctcccactgc
    16921 tcccggtcct cggccccggc cgggagcggt tcgacggcgc cctcggtgca gttcttgagg
    16981 agcgcgtcga gcgcgcggtg ctgctcgggg ccgtacggga aggcgtcccg taccttctgg
    17041 atgagcgcgg gatgccgttc ggccagcacg ctccagggga acgaccccgg ctcgttggag
    17101 aggatcacag gcggggacac ggagtcggag acaggcatga gcctcacgct accgcccccc
    17161 tcaggggcgc gaggaactgc gcgaccagcc acaaccaacc ggtcacccgg cactcaaccg
    17221 caagcccctc cccagtagcc gcacggccag tctcacgcca ccacccttat ctcccgctcc
    17281 agttgcgcca ccaggctcag ataccgcgcc cgcctcggcg tgggcaccaa ggcccggatg
    17341 gtgaggcgcc acatgtccgc cgtacggcgg ggctggcggg ccaccggctc caccgctcgg
    17401 ctcaccacgc ggctgccgac gaagaagctg acaagggagt gcgccatcgc gtcgacgtcg
    17461 atgtccggat ggacgtcgga ctccttgacc gcgccgagga gtttgccgga cgcgatctcc
    17521 gaccactcgc ggaacgggtg ccgcagcggc ggccgtacga cgacgtcgcc ggcggcgaga
    17581 cgcaggcccg cccgggagat cgggccctcg acggccatcc tggtgatccc gaaggtgatg
    17641 cggatcagcg cttcgagcga ggagtagccg cggccctcga tgtccctggc catccgccgg
    17701 gaggtcctgg actggatctc caggatggcg tgggccagat cctccttcgc cgcgaagtgg
    17761 aagtagaggg cgcctttggt gacatgggcg tgctcgacta tgtcgctcag gctggtcgac
    17821 tcatagccat ggcggtcgaa caggtcggcc gcggccgtga tgatcgtcgc acgggtctgc
    17881 tcggcgcgta actgcctcgc catcggcgcc caccccttcc cacaccgtcc cggcgctccc
    17941 gaactccctg aagaaaaacg ggatatgccg tttgtttctt actgcctgta caagatagcc
    18001 gaccgttcca tggtgcccac cacacactcg aaaaccgtgt gtccctcctg tgttcccacc
    18061 accttcaggg ccccgtcacc ttgatccgtg gactctatcc aggtgggcag gtccagttcg
    18121 gcgaactgat ggaaggtcgt gtcgaaggac acgggtatca gcccgccgtc ggggccggtc
    18181 cgcgccagcg ccgcctggcg ggcggcctcc aggagcagca tgcccggtat gtgatcgaga
    18241 ggatggtcga agaaaacagc atgaccggta tcaactcgca actgccagtc acgatcgtcc
    18301 tgttgaggcg gtgccagaac gacgtccgcc gccgagtccc ggcccacgtc ggcggccggc
    18361 agccccggcg ggacgggcag cgcggtcacg ccggccgccg tacgaccgcc gcgcagcctg
    18421 ctgaagacgg cgccgctggt gcaggtgaag gcgacgtcgg catgcgcgac cagctcgccg
    18481 tccagcagta cgtcggccgc gtaacgggcc gaaaccaggc gcttgcctcg atggcggatg
    18541 tcggagaagg tgatgtcgac ggtgggttcg gcagggaccg gcccgacgcc caagtgctcg
    18601 gggaacgtcg tgatccggaa ctcctggagc acgaactggt ggtccagggg cacctggtac
    18661 tcggtgtggt tgagcagggt tccggcctga cgcacggtct ccacgacgag cagcggatcg
    18721 taggccgtcc ggtcggccga cacgtgtaaa cagtggactc gcggccactg tgcggagacg
    18781 ctgaaccggt cggtctccgt tcgggaccag ccggtgggga acgtctccgc gatcgccgca
    18841 cggtgcacga gttggcgcgg aacgctcgcc gtcatgagtg ggatttcggc agactgcggc
    18901 actggaagca atgtctctcc ctcggtcccc cgaatggcgt ggcagacgga aaggcgcccg
    18961 ctccggtgag cgttagagta cgaggcgacc ggtttgtttt caacgagatc agtcggtccg
    19021 gccctatgat cggcggttcc ggcgcacctg accacgcgtc gtcacgcacc agcacggcac
    19081 tgaatacggc accgaatacg gacaccggcc aactgggcgc cagggagggg ctcttatggc
    19141 gaaacaggag cgcgccatca ggacgcgcag ggcgatcctg gaagccgcgg gcgcggtttt
    19201 cgacgaacac ggctacacgt ccacgaccat cgcgatggtc cttgagcggg ccgaggtcac
    19261 caagggcgcc ctgtattttc actttccttc caaggaatcg ctcgcgcagg cggtgctcga
    19321 cgagcaggtg ccgttcggca cggtcccgga acagccctgc aaactgcagg agatcatcga
    19381 catgacgttc gtcgtggcgc agcggctgct gaccgactcc ctgctgcgag gcagcgtgcg
    19441 gctgacggtg gaccaggcga cgccccccgg ggtcgaccac tccggaccgt tccggcagtg
    19501 gggggagcgg ctgatcgtgc tgatggaaca ggctggcgcc cagggcgagt tgctgcccac
    19561 ggtgaagccg caggacacgg tggagctgct ggtggggggc ttcgcgggca tccagttgat
    19621 gtcgcgggcc ctgaccgacc gggcggacct cgcgcaccgt atctcggtcc tgtggtccca
    19681 catcctgccc ggcatcgcgg taccggggct cctgctcgga ctggacagcc gggccgaccg
    19741 cggcgtccgc atcctctccc cggccccggc cccggtcccg gtccccgtcc cgtgattctg
    19801 ctgacggggg ccaccggcac cgtcggccga ctggtcgccg aacgcctggc gggcaccggc
    19861 ccgctgcgcc tgctcacccg cgacccgcac cgcgtcaccc tcgccggtcc cggagtcgag
    19921 gtggtgcgcg gggacttcga cgacgccgcc gggctgcgca cggcgctggc cggcgtacgg
    19981 tccgctctgc tcgtcaccgc gaacccgctg gcgccggccc aggacgagaa cttcgtggcg
    20041 gcctcccgag cggcgggggt acctcaggtg gtgaagctgt cggcccaggc ggtgaccgac
    20101 cccggggcca ccgacctgat cacacggtgg cagcggtgca acgaggaact cctgcgcgcc
    20161 tccggcctgg cgtggacctt gctgcgtccg cgcgccttca tgtccaacac cctgggctgg
    20221 gcccgctccg tccgggagga gggggtcgtc cggggcccct acggcacctc gcggaacgcg
    20281 aacgtcgacc cgcgggacat cgccgacgtg gcggtacggg cgctcacgga cccggaagcg
    20341 cacgcggggc gggcgtacgc gctgaccgga ccggccggag tcactccggt cgaacagacg
    20401 gagatcctgg gcgagttgct gcaacggccc ctgaagttcg tcgagttgac ggaggacgag
    20461 gttctgcggg ggctgctcgc ccgttacccg gaggcggtgg cccacgccct cgtggagagt
    20521 gcggcgcggg ggcgggacgg ggccaagggg caagtggagc cggatgtggc ggagttgctc
    20581 ggccggccgg ggcgctcgta ccgggagtgg gctgcggagc atctggcgga gttcagcggg
    20641 tagctccgct ggatgggcgg ttcgttcgct gcgggtagct ccgctggatc ggcggttcgt
    20701 tcgctgcggg tagctccgct ggatcggcgg ttcgttcgct gcgggccggt gggggctggt
    20761 cgcgcagttc cccgcgcccc tttcgggacg cgggtcccgc gcccgacctc cccaggtcat
    20821 cacgtacggc acatgacagc ggcgggtcgg taagcgtcca tccacgcctg ccgacccgcc
    20881 cgtctctgtc acaccttcag ctcactgaat cagaaggtga gcttccagct gttgatcgtg
    20941 cccgtgtccg aggcggccac gtcctggacg cggagcttcc aggtgccgtt ggccacctcg
    21001 ctggaggcgt ccaccgtgta cgtggcgctc acgttgtcgg cggagtccga ggtgctggag
    21061 gccttcagcg ggtaggtcgt gccgtcgggc gccaccagcg tgatgaccag gtcaccgcgg
    21121 taggtgtggg tgatgtcgac gccgacctgg agggccgagg gggcgttgcc ggtccggccg
    21181 ctgacggcga tcgaggactc gacggcggag ctgttgtccg ggatcgagac cgcggtggtg
    21241 gaggagaagg tggtgcccgt ggtcgtaccg ctcacggcct gcacggtctt ggtcgcgtcg
    21301 gccagaccgg cgccgcagcc gcccgagcag gcgccgggca gggcacggga gttggtcttg
    21361 atcgccgact cgatctgggc cggggtcagc gaggagttcg ccgacttcat cagcgcggcg
    21421 aggcccgcga tgtgcggggc ggccatgctg gtgccctggt agtaggcgta cgactcggtc
    21481 gaagggccct gcgtgccgga gttcagcgtg gacaggatgc cgttggcggt accggtgctg
    21541 gtctggccgc cgggggccgc gatgtccacg gtggagccgt agttggagta cgaggccttg
    21601 gcgcccgtac ggctcagtgc ggcgaccgag atgacgttgc tgcaactggc cggcgagtag
    21661 ttggccgcgt tggcgttgct gttgcccgcc gcgacgacga ccgtggtgcc acggcccacg
    21721 gcgttggtga tcgccgtctg ggtggccgtg gtgcacgcac cggagccgcc caggctcatg
    21781 ttgatgacct tggcgacgtt ggcgttggcc gggactccgg agacggtgcc gccggacgcc
    21841 caggtgatgg cgtcgatgat gtcggagtcg tagccgccgc acttgccgag gacgcgcagc
    21901 ggggagatct tcgcgttgta cgcgatgccc gcgacaccct tgctgttgtt cgtggcggcg
    21961 gcgatggtgc ccgcgacatg ggtgccgtgc caggaggagt tactggagcc ggtgccggtg
    22021 ccgcactcgt cggtggcgta ccagtcgccc gggtcggccg ggttgctgtc acggccgttg
    22081 ccgtccaccg agacggcggt gtcggagatg aagtcgtagc ccgcgacgat gttggcggcc
    22141 aggtcggagt gggtgacata accggtgtcg atgacggcga cggtcacgcc ggtgccggtc
    22201 gcggtggtcc aggcgtccgg gacgcgcatg cccgcggtgg tctcgaagag gtcccactgc
    22261 ttgctgtact cggtgtcgtt cgggtcggcc tgcggcttgt tgaggcggtc cggtacgacg
    22321 taggcgacct gcgggtcggc ctggtactcg gcgatgacgt cggcgacgtc cgccttgctg
    22381 agctgctcgc ccaggtcgac gagggcggca ccggtgccga ggcggcgctg gaagtccagg
    22441 ctctcgccgg cctccttgcc cttcgcgacg gcgtcggcgt cggcggcctg gttcgacctg
    22501 gcctcggcgg cgccggcctt gtagccgacg atgagtcgct cggccgggac ggcgaccgcc
    22561 tgtgcggcgg cttccggtgc ggtggcggga gcggcgggct cctgggcgaa ggcgaccgag
    22621 gtggtggcgg cggcgaccag cgcggcggag accgcggcgg cggatatcag cttccgcccc
    22681 gtggcacggg tgggtgaggt acgcaagggc ttgcctttcg tggccgtact ccgggcagcc
    22741 tggagggcgg cgcggagtgg cggtcgattc gcttcgtcgt cgaagcggcg gggggtgcag
    22801 tcgaaaagcg gcgcggcggc cggccaagcg cgagcggccc gttccggggt tacctgtggg
    22861 gcggctgtgg tggaacagta ggcaaagaga aggtcatccg gatacagggg aaaccctcga
    22921 tccgtccggt tccacaccct cgaacgccgg aaaccgcccc tgaacgacgg ccagttgacc
    22981 gggttgggcg agttacgggg gattggcggc gtgtgcggcg gggcgagcgg cggtgggtgt
    23041 ggcagtcgtg tggcgattga acgcggtctg cccgcttccc gtactgcccg aaggcggacc
    23101 cgttcccggg ccgccccgca gcagacctgt tcagacctgt tccccccctc ggtcgaggag
    23161 acatcccgat gaccgcccac cgccgtactc tctcggccgc cgcactctcc tgcaccgccg
    23221 tcgtcgcggc accgctgttg ctgacgttgt cggcggcggc tcccgcccag gcgcacggtg
    23281 cgccgacgaa accggtcagc cgtgcctacg cctgctcccc cgacggcggc agcacggccg
    23341 gtacggcggc ctgccgggcg gcgctcaccg cgaacggcgg ggcgcccttc accttctggg
    23401 acaacctgcg ggtcgcggac gtgaacggcc gggaccgcgc ggtgatcccc gacggcaagc
    23461 tgtgcagcgg cgggctgccc gactaccggg ggctcgacat cgcccgcgcc gactggccca
    23521 cgaccacgtt gtcgccgggc gcgcggctga cgatgacgta ccgctcgacg atcccgcaca
    23581 ccggcacgtt caagatgttc ctgacgaagc ccgggtacga cccggccgag ccgctgaagt
    23641 ggtccgacct gccggccaag ccgttcgccg aggtcaagga cccgtcgatg acgggcgacg
    23701 cgtaccgcat caacatgacg ctgccctcgg accggaccgg ccgccacgtc ctgtacacga
    23761 tctggcagaa ctccagtacg ccggacacgt actactcgtg ctcggacgtg gttttcccga
    23821 aagcgaagag cgacgggggc aactccggcg gcgccggcag ctccgacgcg tccgc
//
