LOCUS       NZ_CP054019            21077 bp    DNA     linear   CON 28-JAN-2024
DEFINITION  Streptomyces sp. A1-5 chromosome.
ACCESSION   NZ_CP054019
VERSION     NZ_CP054019.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. A1-5
  ORGANISM  Streptomyces sp. A1-5
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9459690)
  AUTHORS   Dashti,Y., Sumang,F.A.M., de los Santos,E.L.C., Alcantara,E.P. and
            Challis,G.L.
  TITLE     Structural revision and biosynthesis of polyketides FXJ15321 and
            FXJ15322 from Streptomyces sp. A1-5
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9459690)
  AUTHORS   de los Santos,E.L.C.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAY-2020) Warwick Integrative Synthetic Biology
            Centre, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL,
            United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: JUN-2019
            Assembly Method                   :: Flye v. 2.4.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology :: Oxford Nanopore MiniION; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/28/2024 04:28:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,328
            CDSs (total)                      :: 8,230
            Genes (coding)                    :: 7,847
            CDSs (with protein)               :: 7,847
            Genes (RNA)                       :: 98
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 74
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 383
            CDSs (without protein)            :: 383
            Pseudo Genes (ambiguous residues) :: 0 of 383
            Pseudo Genes (frameshifted)       :: 156 of 383
            Pseudo Genes (incomplete)         :: 280 of 383
            Pseudo Genes (internal stop)      :: 26 of 383
            Pseudo Genes (multiple problems)  :: 73 of 383
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:08:01
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8094046
            Orig. end                         :: 8115123
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP054019.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Philippine National
            Collection of Microorganisms.
FEATURES             Location/Qualifiers
     region          1..21077
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="33"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21077
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21077
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11077](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11077
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            complement(303..1655)
                     /locus_tag="HRD51_RS35585"
                     /old_locus_tag="HRD51_35145"
     CDS             complement(303..1655)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024907.4"
                     /locus_tag="HRD51_RS35585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_35145"
                     /product="VCBS repeat-containing protein"
                     /protein_id="WP_235095168.1"
                     /transl_table=11
                     /translation="MSTFAAKLKKTSVATLVVAAAVTGLGIAGPAAAPAHAAGTSAVGG
                     EITTAEVMSRAQYWVDRAVPYSQSDYDPDPQGRNYRQDCSGFVSMAWHLNTSLTTWTLP
                     QVATRLSSLDELQPGDMLDNIDSHVVLFGGWADSGRTTAKVWEEAHQGTTARVNSSYYT
                     RSYINNHGFRPYRYTKIVESKPTPKDVGMTNLTGGDFGGDGKADVVAVEASSGKLFSYP
                     GIGGGRLGDRVQAGTGWNTMSELTSGYFTGSGKLDLAAVDNDGVLWIYPGNGNGTFGNR
                     VKAGTGWDGMHDLAGADLNKDGKSDLVAVESSTGKLYAYPGNGNGTFGNRVQIGSGWNG
                     MDQIVSPGDMNKDGNADIVAREVSTGNLYVYPGTGSFNGTNTLGSRTQIGSGWDSMTNL
                     VSGDFNGDGIGDVDAVQAKVGETGTFYSYPGTGAINGTNTLGARVQIGTGW"
     gene            complement(1757..2956)
                     /locus_tag="HRD51_RS35590"
                     /old_locus_tag="HRD51_35150"
     CDS             complement(1757..2956)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003955810.1"
                     /locus_tag="HRD51_RS35590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_35150"
                     /product="FG-GAP-like repeat-containing protein"
                     /protein_id="WP_328285892.1"
                     /transl_table=11
                     /translation="MPETPRATSRTAWKSAATAALTLAGLTLSLVSAAPATAASLGTWD
                     KVAQCESSGNWQINTGNGYYGGVQIYLPTWNAYGGREYATYPHQATKQQQILIAEKILA
                     GQGAGAWGSCGASAGLGGDHADPYPTTPPAPVGMVHLTAADFTGDGRKDLVGVESATGK
                     LWLYPGKGDGTFGDRVQIGTGWNAMSKLAAADYTGDGKADLLAVENSTGNLFLYPGTGS
                     AVGMNTLGARTQIGSGWGGMRDLTAIDVNKDGKPDLVAVDTNGSLWAYPGTGSLAGSST
                     LGGRVQIGTGWNSMAELASPGDLDSDGKADLVAVDPAGALWKYPGTGALNGSNTFGARN
                     QIGSGWNSMHQLVGADFNNDGKGDLDAVQAQAGSTGGLYFYPGNGSGGLADRARIGTGW
                     "
     gene            complement(3345..3743)
                     /locus_tag="HRD51_RS35600"
                     /old_locus_tag="HRD51_35155"
     CDS             complement(3345..3743)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HRD51_RS35600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HRD51_35155"
                     /product="hypothetical protein"
                     /protein_id="WP_205368644.1"
                     /transl_table=11
                     /translation="MYLVHARLQGPPGASLPLETRSLVRSQIHDGDGVEHVTVHPDALP
                     HPVVGLYVRADSLAAAEYRAALVCRLLLGCAGFDGWSLPVVEAPMVAPFYESRLSDPGP
                     AGPAMDGCGQGHFGPAENPSTPSDQQRK"
     gene            3926..4924
                     /locus_tag="HRD51_RS35605"
                     /old_locus_tag="HRD51_35160"
     CDS             3926..4924
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020119290.1"
                     /locus_tag="HRD51_RS35605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_35160"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_235095169.1"
                     /transl_table=11
                     /translation="MLTALGLDAVAESVYRAMLADPPGGIAELVARVGKPEDEVRDALD
                     LLSELALVRPSIEQPGRPRAVSPEIGMEILMARQQADLAAQQQRLETSRAVAAQLIAEY
                     ADLRPAASSPGVEQLIGIEQIRDRLARLTRDVTTDVMSFAPGGAQPAAQMKASRPLDEQ
                     LLGRGVRIRTVYLSSVRNDQPTVDYANWLTDLGGQIRTTPALPTRMIITDGSTAVIPVS
                     SDDTATGAVVLTSQGTLTALCALFEGVWSCAQPLGEAAPRNSHGLNPQESTTIALLAQG
                     HTDEAIAKRLGVSQRTARRIATDLMERLGARSRFAAGARAVQHGWLPSQPT"
     gene            complement(5303..5557)
                     /locus_tag="HRD51_RS35610"
                     /old_locus_tag="HRD51_35165"
     CDS             complement(5303..5557)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HRD51_RS35610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HRD51_35165"
                     /product="hypothetical protein"
                     /protein_id="WP_205368643.1"
                     /transl_table=11
                     /translation="MVPGDRGYDHGKFRRQVWDLGVQPPIARPGTEHGSGSGTQRWFAE
                     RAFTHLRRFRRLRIRWEIRDDIHQAFITHNFRKEATFRE"
     gene            5791..6189
                     /locus_tag="HRD51_RS35615"
                     /old_locus_tag="HRD51_35170"
     CDS             5791..6189
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004938818.1"
                     /locus_tag="HRD51_RS35615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_35170"
                     /product="spore germination protein GerW family protein"
                     /protein_id="WP_235095170.1"
                     /transl_table=11
                     /translation="MTDSDTPDQPVPQADMAAALMERLAEQLGSRASASAVFGEPVTSD
                     GITVIPVAEFGFGFAGGMGPEAGSANTGEGGGGAGARPRGYIEIKDGTATYKPLRVPWV
                     NVAVPLAALMAGAVVPLLVRRLAKRRTR"
     gene            complement(6462..7346)
                     /locus_tag="HRD51_RS35620"
                     /old_locus_tag="HRD51_35175"
     CDS             complement(6462..7346)
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1100: 3-hydroxyisobutyrate dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019885069.1"
                     /locus_tag="HRD51_RS35620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_35175"
                     /product="NAD(P)-binding domain-containing protein"
                     /protein_id="WP_235095171.1"
                     /transl_table=11
                     /translation="MNNTTETPVTIIGLGRMGQALASAFLKAGHPTTVWNRTASKADQL
                     VAEGAVLAPTVSDALKSGSLTIVCVTDYQAMHNLLGADDIDLDGMTLVNLTSGDSTQAR
                     EAAQWAEQRGARYLDGAIMAIPPAIGTAEATILHSGPQADFEAHRTTLDALGTVTYLGA
                     DHGLASLYDVAGLAMMWSVLNAWLQGTALLRTAGVDAVTYAPFAQQIATGVAAWLPGHA
                     EQIDSSSFPAKVASLETHVRSMAHLIEESEAVGVNAELPKLIKAMADRAIAAGHGGEQY
                     PVLIEEFGKPRHD"
     misc_feature    complement(7353..7367)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.58"
                     /tool="antismash"
     gene            7396..7803
                     /locus_tag="HRD51_RS35625"
                     /old_locus_tag="HRD51_35180"
     CDS             7396..7803
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019885070.1"
                     /locus_tag="HRD51_RS35625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_35180"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_205368640.1"
                     /transl_table=11
                     /translation="MRIGELGRRTGVNTHQLRYYEAQGLLEADRGANGYREFDENAVLR
                     VRQIRHLLGAGLSSEDIAYVLPCAVGEAPQLPGCPELLAAMRSRLQRLDDRMGSLAQSR
                     DALADYIDAAERMAGESYPPFDHAGQEPVPS"
     gene            complement(8153..8512)
                     /locus_tag="HRD51_RS35630"
                     /old_locus_tag="HRD51_35185"
     CDS             complement(8153..8512)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018540838.1"
                     /locus_tag="HRD51_RS35630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_35185"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_205368639.1"
                     /transl_table=11
                     /translation="MRIGELARRTGVSERSLRYYEQQGLLASERTPGGHRDYPERAVDR
                     VIRIQELFAAGLCSKKIAQLLPCIRDHDGGPAVTATPWLVQELLAERERIHRTIADLRR
                     SQATLDEVIDAASRP"
     gene            8572..9693
                     /locus_tag="HRD51_RS35635"
                     /old_locus_tag="HRD51_35190"
     CDS             8572..9693
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018541840.1"
                     /locus_tag="HRD51_RS35635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_35190"
                     /product="alkene reductase"
                     /protein_id="WP_235095172.1"
                     /transl_table=11
                     /translation="MMKLLTPFTSAELTLSNRIVMAPMTRFRAEEDGTPLPIVADYYRQ
                     RAGAGLIVTEGIWPSLRGQSGWRIPGLESERHVSAWQHVTEAVHDAGGRIFAQLMHGGR
                     QGHPRSRVLGDIPAGPSAVPVPGPVHVKDGKADPVIPRAMTHDDIRTAIADHVAAARNA
                     IRAGFDGVELHGANSYLIHQFLADNTNLRTDAYGGDISGRIRFPLELVQAVTDTVGAGR
                     LGLRLSPGNPQFGMEEADPAPVYRALLARLDGLGLAYLHLTDDDRYPALADLRPRWHGT
                     LIANVGENRAPTTREAGEAVLASGRADLVSYGRLFISNPDLPHRFAAGLPLNTHIDQSA
                     LYGHGAAGYTHYPAWQESSRPIMRSVVPSSPGR"
     gene            10001..11077
                     /locus_tag="HRD51_RS35640"
                     /old_locus_tag="HRD51_35195"
     CDS             10001..11077
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018540840.1"
                     /locus_tag="HRD51_RS35640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_35195"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_235095173.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 8e-39, bitscore:
                     132.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTADNAAGVHERLAGYQERFNGLFANYFDSVAEQGPPRNAFVPEA
                     LELVRDMSLRGGKRLRVALLYEAARLVAPAAVPGLDEAALSIELLQTHGLIHDDIIDDS
                     PVRRGAPSVYYAYRERFPGRPQTALGLAVLAGDLAAFLSVQVLLTAPVPRELRQAMAAV
                     QATAGADTVRGQFLDLERDFGPMPDREVLDTVSEYKSARYSVLAPLQLGLLAAGADPAA
                     HENELARYARLLGVSGQMRDDYLDLFADAGTVGKPAGSDLREGRRSYAVCALLAATSGA
                     ERAVVESALAGPGCPPETVERIQDIARRHGVDTELLAEIRRCAQEAAAVAANWRGRWRD
                     EAVEFFEQLPLWGVLRTQ"
     tRNA            complement(11231..11304)
                     /anticodon=(pos:complement(8105314..8105316),aa:Met,
                     seq:cat)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HRD51_RS35645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="HRD51_35200"
                     /product="tRNA-Met"
     gene            complement(11231..11304)
                     /locus_tag="HRD51_RS35645"
                     /old_locus_tag="HRD51_35200"
     gene            11650..12390
                     /locus_tag="HRD51_RS35650"
                     /old_locus_tag="HRD51_35205"
     CDS             11650..12390
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020130853.1"
                     /locus_tag="HRD51_RS35650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_35205"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_235096191.1"
                     /transl_table=11
                     /translation="MRPVPEGSAGPGGQAVPNDYDSFAEAYSAQNETSLFNAHYERPAM
                     LDLAGDVAGRRILDAGCGSGPLSAALRDRGAIVTGFDSSTKMLELARKRLGDDAALHLA
                     DLGSPLPFPDAAFDDVVASLVLHYLEDWTAPLAELRRVLTPGGRLIVSVDHPSIGLVQP
                     GTDYFATYQHSEEWTLGGHTALMTFWHRPLHAMTDAFTAAGFRINVISEPLPAPGAREL
                     FPDIFVDKPSGAFVCFLFFVLQAD"
     gene            complement(12398..>12756)
                     /locus_tag="HRD51_RS35655"
                     /pseudo=""
     CDS             complement(12398..>12756)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003969235.1"
                     /locus_tag="HRD51_RS35655"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="EIRKIAKSKPTGHGLPFSTWSPAELADFLVAEGVVDGISHEGLRV
                     LVREEGVSFQPRPTPPGSTASSPSSPPRATSPWTAPTTPAIQGRAA"
     gene            complement(13209..15962)
                     /locus_tag="HRD51_RS35660"
                     /old_locus_tag="HRD51_35210"
     CDS             complement(13209..15962)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014054569.1"
                     /locus_tag="HRD51_RS35660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_35210"
                     /product="bifunctional YncE family protein/alkaline
                     phosphatase family protein"
                     /protein_id="WP_235095174.1"
                     /transl_table=11
                     /translation="MQVIRRRRHDANDRAGNLRRRFSRRGTLATATAVVLAATAGIGYA
                     QTHQFGTARVGQKTADGQVVSSDQYIAPYGDRLVIDDGKIMSSSVSPDGTHVAASLTDG
                     GAALAIVDRKNWKVQQLVGASASSTPRISSNSVGQEGPTYSPDGKQLWLGQTDGYTKFT
                     VNPDGSVSNPTFIKIPADGTKHALVGEPVFSSDGSTVYAAVNGQNKVVALDAATGAVKH
                     SWAVGNAPRDMVKVGHKLYVSNEGGRPAKPGEPTINSYGTQVPADPKTGATTTGTVSVI
                     DLAKPGAAVKSIDVGLHPTALYAKGGALFVTNTATNDVSVISTTGDKVVQTIATRPWPE
                     ASVGYEPNAVTLTDDGHLLVTLGRANAVAVYKYKSPQEPVSYVGLLPTDYFPSEIATVG
                     KQVLVSNSRGIDARRPTASGAHGTHDTTSSLQRFTLPDDSVIRSETAKVFKQNGWTGDS
                     VKRTDGTSHAKPTAVPKRLGDPSTIKHVFLIVKENRTYDQVFGDLPQGNGDPKLTQFGE
                     NVTPNQHALAKQFGLYDNTYDIGTNSAEGHNWLMQSDNPEYTESSAGEYQRSYDTENDA
                     LGHQKSGFLWTGAQAAGRSVKDFGEFQSVESKPSGASWQNLYCDARTMDATGRPTAYPI
                     KTGSAIPSLNDVSVPGFPMFDLDVPDIYKYQVWKQDFEKNGPANLNMFWFSNDHTGGPA
                     SPSAQVADNDLAVGKMVDKISHSKYWKDSAIFVVEDDSQAGLDHVDGHRAPIQIISPWA
                     QHGRTDSHYYTQITMIRTIEQILGIHPMNQKDSAASPMSGAFTAHPDTAPFKAQPNRVP
                     LTDGLKTQPPCGSDNPAAQSPRAAAVSPATVPADKQDLAATWDKWKSKQRLTGPHAVPD
                     YANPAQMNHLTWYETHNWNRPYPGENKIFAPQDVPGAYLPSSENDG"
     gene            complement(15967..17340)
                     /locus_tag="HRD51_RS35665"
                     /old_locus_tag="HRD51_35215"
     CDS             complement(15967..17340)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014182233.1"
                     /locus_tag="HRD51_RS35665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_35215"
                     /product="ABC transporter permease"
                     /protein_id="WP_235095175.1"
                     /transl_table=11
                     /translation="MNAPLTHAQARPHGAGTRRASVARGYRFELVKLVSQWRIRLLVLA
                     CWIAPALFVAAVSQQSTLPVDTLFGRWMHATGWAGPLVTLGFAGTWALPLLTSVVAGDV
                     FAAEDRLGTWRHLLVAVRSPRRIFAAKAFASLTVLLLLVAGLACSSAAGGVVAVGNQPL
                     VGLDGHLLTPADAAVKVLLAWVCVLAPTLSLAGIGLLGSVALGRSPMGLLLPVLVALAM
                     QLAQMMPLPVAVRLALPSYAFIAWNGLFTGPAQLAPLLIGTGVSLAWAVLATALAYLLF
                     LRRDFTNLSYDGSGRRTVTVGFLPLAGLVAVTVAVLTTSATATATGSGIEQDKVQRSVA
                     TAFAHLYRMQTEQLHRPHVTEAQLKAEATCTKGSLQTAAQGAGNDWRCVVSWHLPGVDA
                     AGQAIYQLDVTPDGRFMADGDGPKEVNGYFLVRTPQGDAPNPLWQFDGNVALLATSKG"
     gene            complement(17337..18278)
                     /locus_tag="HRD51_RS35670"
                     /old_locus_tag="HRD51_35220"
     CDS             complement(17337..18278)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018557399.1"
                     /locus_tag="HRD51_RS35670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_35220"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_235095176.1"
                     /transl_table=11
                     /translation="MDALLAVRARGITKWFGDVVALDGVDLDVTQGQIHGLVGPNGAGK
                     TTLLGLLLGLAVADSGSLQILGTPVGRALDAPDGVAGFVDGPGLYPSLTARQNLAALAA
                     LRGDDARTTAIDDALAQVGLTDVADDRASGFSLGMRQRLGLAAALLTKPRLLVLDEPSN
                     GLDPAGKKHVHGVLTRLATDGTGVVLSSHRMDDVEALCSDVSILAAGRVVFSGPLSKLA
                     AEERELDYRVRTSDAHAARRLAAETAGIRLADDAGARHDAQVLVVRAQVPALDELVVRL
                     VRAGIAVRELSPVVSPLEAAFLALTEPEEAGR"
     gene            18432..18671
                     /locus_tag="HRD51_RS35675"
                     /old_locus_tag="HRD51_35225"
     CDS             18432..18671
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HRD51_RS35675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HRD51_35225"
                     /product="hypothetical protein"
                     /protein_id="WP_205368632.1"
                     /transl_table=11
                     /translation="MTACAAVAFATLAVSVSPLTTGTAHADTPAPAGLSLSPRLTQADG
                     LAPSLDPAKDSPDYGTESVVNKTSDGELEHVAQR"
     gene            complement(18953..19207)
                     /locus_tag="HRD51_RS35680"
                     /old_locus_tag="HRD51_35235"
     CDS             complement(18953..19207)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HRD51_RS35680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HRD51_35235"
                     /product="hypothetical protein"
                     /protein_id="WP_235095177.1"
                     /transl_table=11
                     /translation="MEINALISTRPNPDHPPLDPRIHRHHPIADIATILPVVGSAEAAP
                     TWTSRSADRWAGSRRCAPTLATAPASSAVGFLSKVVCIR"
     gene            complement(19290..20147)
                     /locus_tag="HRD51_RS35685"
                     /old_locus_tag="HRD51_35240"
     CDS             complement(19290..20147)
                     /GO_function="GO:0030598 - rRNA N-glycosylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0017148 - negative regulation of
                     translation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012388.4"
                     /locus_tag="HRD51_RS35685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_35240"
                     /product="ribosome-inactivating family protein"
                     /protein_id="WP_205368631.1"
                     /transl_table=11
                     /translation="MDSATVTNRAANRPSYSTVHWVDTHDSNRYLAMLQQLRTAVGHSF
                     RNNVQETTHDRNQLVALNVTRDLGEGGDGRQHQVESVTIYFNASNMYFLGWSSDDTGRL
                     YQLNGTNLGRRLAWSGEHQPITLPFGESYTALQRAAGWESRGAMEITANSIDSSVQTLH
                     DGVNLNNRNGVRDTARAVLRMVTITSEAVRFNPIGTGVANAFLTGTPYQLTPLQQELET
                     NWGRLSDFVHDVSQHAHAAPVQIGPASRNGNDTQAVRIETFEQAAQYTGLIIYQAHVNS
                     HDGL"
     misc_feature    complement(21010..21019)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
ORIGIN
        1 attccgtcgg tgctggtccg ggtgatgctg ttgtaggtgg cggtggtccc gtcgggagcc
       61 gtcccggcga cggcgtggcc gccggtggcc agggaggcga gcgccatcac gcccgccacc
      121 gcggcgcctc gccctcgggc gcgggtcctg cggaggaggt gtcggcgtgc catggcggca
      181 ctggtccttt catcggccgg gtcggttccc ggagagtggc ggggagcagg cggggccgcc
      241 accgcggtgt gggtgcggtg gcggcccttc ggagagcggc ggtcgggggc cttgcggcgg
      301 gattaccagc cggtgccgat ctggacgcgg gcgcccaggg tgttggtgcc gttgatggcg
      361 ccggtgcccg ggtagctgta gaaggtgccg gtctcgccga ccttggcctg gacggcatcc
      421 acgtcgccga tgccgtcacc gttgaagtcg ccgctgacca ggttggtcat cgagtcccag
      481 ccggagccga tctgggtacg ggagccgagg gtgttggtgc cgttgaagga gccggtgccc
      541 gggtagacgt acaggttgcc ggtggagacc tcacgggcca cgatgtcggc gttgccgtcc
      601 ttgttcatgt cgccggggct gacgatctgg tccatgccgt tccagccgga gccgatctgg
      661 acgcggttgc cgaaggtgcc gttgccgttg cccgggtagg cgtagagctt gccggtggag
      721 gactcgacgg ccaccaggtc gctcttgccg tccttgttga ggtcggcgcc cgccaggtcg
      781 tgcatgccgt cccaaccggt gcccgccttg acgcggttgc cgaaggtgcc gttgccgttg
      841 cccgggtaga tccacagcac tccgtcgttg tcgacggccg cgaggtccag cttgcccgag
      901 ccggtgaagt acccggaggt cagctcgctc atcgtgttcc agccggtgcc ggcctggacg
      961 cggtcgccga gccggccgcc gccgatgccc gggtaggaga acagcttgcc gctggacgct
     1021 tcgaccgcga ccacgtcggc cttgccgtca ccgccgaagt cgccgccggt gaggttggtc
     1081 atgccgacgt ccttcggagt cggcttggac tccacgatct tggtgtagcg gtaggggcgg
     1141 aagccgtggt tgttgatgta actgcgggtg taataggacg agttgacgcg ggcggtggtg
     1201 ccctggtggg cctcttccca gaccttcgcc gtggtgcggc ccgagtcggc ccagccgccg
     1261 aagagcacga cgtgggagtc tatgttgtcg agcatgtcgc cgggctgcag ctcgtccagg
     1321 ctggacagcc gggtggcgac ctgcggcagc gtccaggtgg tgaggctggt gttcaggtgc
     1381 caggccatcg agacgaaccc ggagcagtcc tggcggtaat tgcggccctg cgggtccggg
     1441 tcgtagtcag actggctgta cggaacggcg cggtcgaccc agtactgggc acgggacatg
     1501 acctctgcgg tggtgatctc gcccccgacg gcggaggtgc cggccgcatg ggccggggca
     1561 gcggccggtc cggcgatgcc cagaccggtg accgcggcgg cgacgaccag ggtggcgacg
     1621 ctggtcttct tcaacttggc tgcgaacgtg gacatgacgg gtctcctgaa atctgaaagc
     1681 gtgaaagtcc ggaagcggcg cggcggactg ccgcgcgagc ggtgcaggcg tagcgaagtc
     1741 ggtgcgggtg gcgcggctac cagccggtgc cgatccgggc gcggtcggcg aggccgccgc
     1801 tgccgttgcc ggggtagaag tagaggccgc cggtggaacc ggcctgtgcc tggacggcgt
     1861 ccagatcacc cttgccgtcg ttgttgaagt cggcgccgac cagctggtgc atgctgttcc
     1921 agccggaacc gatctggttg cgggccccga aggtgttgct gccgttgagg gcgccggtgc
     1981 cggggtactt ccacagcgcg ccggccgggt cgacggcgac gaggtcggcc ttgccgtccg
     2041 agtcgaggtc gccggggctc gccagctcgg ccatgctgtt ccagccggtg ccgatctgga
     2101 cgcggccgcc cagggtgctg ctgcccgcga gggacccggt acccgggtag gcccacaggc
     2161 tgccgttggt gtccacggca accagatccg gcttgccgtc cttgttcacg tcgatcgcgg
     2221 tgaggtcccg catgccgccc cagccggagc cgatctgggt ccgggcaccc agggtgttca
     2281 tgccgaccgc gctgccggtg cccgggtaga ggaagagatt cccggtggag ttctcgacgg
     2341 cgagcaggtc ggccttgccg tcgccggtgt agtcggcggc ggcgagcttg ctcatggcgt
     2401 tccagccggt accgatctgg acacggtcgc cgaaggtgcc gtcgcccttg ccggggtaga
     2461 gccacagctt tccggtggcc gattcgacgc cgaccaggtc ctttctgcca tcaccggtga
     2521 agtccgcggc cgtcaggtgg accatgccga ccggcgcggg cggggtggtg gggtaggggt
     2581 cggcgtggtc accgccaagg ccggcgctcg ccccgcagct tccccaggcg cccgcaccct
     2641 gcccggcgag gatcttctcg gctatcagga tctgctgctg cttggtggcc tggtgcgggt
     2701 aagtggcgta ctcgcggccg ccgtaggcgt tccacgtcgg caggtagatc tgcacgccgc
     2761 cgtagtagcc gttgccggtg ttgatctgcc agttcccgct ggactcgcac tgggcgacct
     2821 tgtcccacgt gccgagcgag gcagcggtcg cgggggcagc ggagacgagg gagagggtga
     2881 gacctgcgag ggtcagggcg gccgtggcgg cggacttcca ggccgtacgg gacgtggcgc
     2941 ggggtgtttc gggcatggcg gaacctcaat agtggcgatg cgggatgcag tgacgggcgg
     3001 caccggcagc tgccgggcct acccggtgcg gctcggtact gcgggtgttg cgcagcatgt
     3061 gcggccggga caccgggctg ctgcagctgc cctacggagc ggctgggagc ggtccggggt
     3121 gatggggccg aagccggggg ctacgaccag cccatggtct gcctgggggc ggcggtcgcg
     3181 gccgaggcgg cgatggtggc gaccgcggcg gccgtggcga gacggagacg aagcatgggg
     3241 aaagccctct tctgacgttg tgtcggtgtc ctcgaccggt tcgcatcccg cggtgatgct
     3301 gtccggtccg ttgcccgccg ggcggtgttc cctgcgggca agaactactt tcgctgctgg
     3361 tcagaggggg tggaagggtt ttcggctgga ccaaaatggc cttggccgca tccgtccatc
     3421 gccggaccgg cgggtcccgg gtcggacaac cgcgactcgt agaagggggc gaccatcggc
     3481 gcctcgacga ccggcagtga ccagccgtcg aacccggcgc agcccagcag cagccggcag
     3541 accagggccg cccggtattc cgcggcggcc aggctgtcgg cgcgtacgta gagaccgacc
     3601 accgggtggg gcagagcatc cgggtggacg gtgacgtgct cgacgccgtc gccgtcatgg
     3661 atctgggaac ggaccaagga ccgcgtctca agcgggaggg aagcaccggg cggtccctgc
     3721 aggcgggcgt ggacgagata catgacccga ctgtcccaaa ccgacaactc gcctaccagg
     3781 agcggaatgt ggacgcttcc gtccatggac acttcggtcc agcgccgaac tatttcctta
     3841 tgccggacat acagatatcg gccccgtatg gcatgatcca cacgaatcca ggggtggagt
     3901 tgtgcatgaa tgagggggat gtgcgttgct gaccgcattg ggactcgacg cagtcgcgga
     3961 gtccgtctac cgcgcgatgc tggccgatcc gccgggcggg atcgccgagc tcgtcgccag
     4021 ggtgggcaag cccgaggacg aggtgcgcga tgccctcgac ctgctcagcg agttggccct
     4081 ggtgcggccg tcgatcgagc agccaggaag gccgagggcg gtctcgccgg agatcggcat
     4141 ggagatcctg atggcccgcc aacaggcgga cctggccgca caacagcagc gcctggagac
     4201 ctcgcgcgcc gtcgccgcgc agctgatcgc cgaatacgcg gatctgcgcc cggccgcctc
     4261 cagccccggc gtcgagcaac tcatcggcat cgaacagatc cgggaccgcc tcgccaggct
     4321 cacccgcgat gtgaccaccg acgtcatgtc gttcgccccg ggcggcgccc agcccgcggc
     4381 ccagatgaag gcgtcgcgcc cgctggacga gcagttgctg gggcgggggg tgcggatacg
     4441 caccgtctac ctcagcagcg tccgcaacga ccagcccacc gtcgactatg ccaactggct
     4501 cacggacctg ggcggtcaga tccgtaccac cccggccctg cccacccgaa tgatcatcac
     4561 tgacggctcg accgcggtca tccccgtcag cagcgacgac accgccaccg gcgccgtcgt
     4621 cctcaccagc cagggcactc tcaccgcact gtgcgccctc ttcgagggcg tctggtcctg
     4681 cgctcagcca ctcggcgagg ccgctcccag gaactcccac gggctgaacc cgcaagagtc
     4741 caccaccatc gccctgctgg cacagggcca cacggacgag gccatcgcca aacgcctggg
     4801 ggtctcccag cgcacggcgc gacgcatcgc gaccgacctg atggaacgcc tcggcgcccg
     4861 cagccgcttc gcggcgggcg cgcgagccgt gcagcacggc tggctgccgt cgcagcccac
     4921 ctgagctcgg gaaaagctgc ctcggaaaga gcactactgg gcacattcga ggccgttcag
     4981 ctctttatct cagcgaaccc aggcttctga cgtgcatcgg ccgtcagctt cgccggacca
     5041 acggagcggc cttacccggc ccattgcccc ttacccggtg actcactggg ggaagccccg
     5101 gtgactctcg ggttcctggt gccgggaatg gccagcacat gcggaccgtg gtggagggtc
     5161 caggccggca tcgcgcagct cgcccgaacc ccgggttcgc ccctgtcacc acggctatgt
     5221 acgcaatcgt catgctcgac atgatcctct caaggctcgt ctcacgaggg gggagacgcc
     5281 tgcgactcgt cagccgacgt cgtcactccc ggaacgtggc ctccttgcgg aagttgtgcg
     5341 tgatgaatgc ttggtggatg tcgtcgcgga tctcccagcg gatccgcagc cggcggaacc
     5401 ggcgcaggtg ggtgaacgcc cgctctgcga accagcgttg ggtgcccgag ccggagccgt
     5461 gctcggtgcc ggggcgggcg atcggtggct gcacgccgag atcccagacc tgacgccgga
     5521 acttgccgtg gtcgtagccg cggtcacccg gcaccacgtc cgggcggcgt cggggccgcc
     5581 cccacctgga gttgtgacag gcagggctgg gccaggacgc acgtcggccc ggcggcctcg
     5641 gcccagggac cactgtttgg cgcggcccaa gggggcttcg aggcggccgt ggtgtgcccg
     5701 gctccccgct gtgcaacccg attcgcctgt ggcccatgcc aggcacccat atcctcggta
     5761 ccgccgtacc cgccaccccg gaggtatccg atgaccgact cagacacacc ggaccagccc
     5821 gtcccgcagg ccgacatggc cgcagccctg atggaacgcc tggccgaaca gctcggtagt
     5881 cgggcctcgg cgtcagccgt cttcggcgaa cccgtcacca gcgacggaat caccgtcatt
     5941 ccggttgccg aattcggctt cgggttcgcc ggaggcatgg gccccgaagc cggatccgcc
     6001 aacaccggcg aaggaggggg cggagccggt gcccgccccc gcggctacat cgagatcaaa
     6061 gacggtaccg ccacctacaa acccctccga gtcccctggg tgaatgtcgc cgtaccgctg
     6121 gccgccctca tggcaggagc cgtcgtcccc ctgctcgttc gccgcctcgc caagcgccgc
     6181 actcgctgac cacctgcaac aacgaaccag acatcaactc acgtaccgcc agcggcaggt
     6241 ccccggcttg cgagaccaca ccacgaccgc cgacctcaat gcgtacacgc agggaggacc
     6301 cgatgcgcct cttcacttgg aaagcgcctc tgaaccaggc acgaacgagg acctcggcaa
     6361 tcctcattgc ggctgttcag aggcgctttc cgcggtgctg accacctgtc ggacagcccg
     6421 tcaccccacc acccgaggtg agatcccggt gtcggtaccg gtcagtcgtg gcggggtttg
     6481 ccgaactctt cgatcagcac gggatactgc tccccgccgt gtccggcggc gatcgcgcgg
     6541 tcggccatcg ccttgatcaa cttcggcagt tcggcgttga cacccaccgc ctcgctctcc
     6601 tcgatcaggt gcgccattga ccggacatgg gtctccaggg acgccacctt ggcagggaag
     6661 gagctgctgt cgatctgttc ggcgtgcccc ggcagccatg cggccacccc ggtggcgatc
     6721 tgctgcgcga acggcgcata cgtcacggcg tccacaccgg ccgtcctgag cagggccgtg
     6781 ccctggagcc aggcgttcag gacgctccac atcatggcca ggcccgccac gtcgtacagg
     6841 gacgccagcc cgtgatccgc gccaaggtag gtgacagtgc cgagtgcgtc gagtgttgtc
     6901 ctgtgtgcct cgaagtccgc ctgcggcccg ctgtgcagaa tcgtcgcctc agcggttccg
     6961 atcgccggtg ggatcgccat gatggcgccg tccaggtaac gggcgccacg ctgctcggcc
     7021 cattgggcgg cctccctggc ctgggtcgag tcacccgagg tcaggttcac cagcgtcatg
     7081 ccgtccaggt cgatatcgtc cgcgccgagc agattgtgca tggcctggta gtcggtgacg
     7141 cagacgatcg tcagggaacc cgacttgagt gcgtcgctca ccgttggcgc cagcacggca
     7201 ccctcggcaa ccaactggtc ggccttggag gccgtacggt tccacacggt ggtggggtgc
     7261 ccggctttga ggaacgcgct ggcgagtgcc tggcccatcc gtccaaggcc gatgatggtc
     7321 acaggtgttt cggtggtgtt gttcatggca gcatcgtcaa cgttgatacc ggtgtgaagg
     7381 tcaagcgagg ttttgatgcg gatcggggaa ctggggcgtc ggacgggcgt caacacccat
     7441 cagttgcgct actacgaggc ccagggcctg ctggaggcgg accgcggcgc gaacggctac
     7501 cgcgaattcg acgagaacgc cgtgctgcgg gtcaggcaga tccggcatct gctgggtgcc
     7561 ggtttgtcct ccgaggacat cgcgtacgtg ctgccctgcg cggtcggcga ggccccgcag
     7621 ttgcccgggt gtcccgagtt gctcgctgcg atgcggtcac ggctgcagcg actggacgat
     7681 cggatgggca gcctcgctca atcccgcgac gctcttgccg actacatcga cgcggccgag
     7741 cggatggccg gcgagagcta tccgcccttc gaccatgccg gccaagagcc cgtcccctcc
     7801 tgagcagccg ggtgcccgtc ttgcggaccg tctcgaccag caacactccg cctgcctgcg
     7861 cggccaccgc ccatgccccg gcctgaacac gaacacgaac acgcggatac ggagcaacac
     7921 gcccacccgg taagtgtctt ctttcccgcg gtggacggag ccttgggcaa gtcccatctt
     7981 cccaagccag gagcgccctc tgctcgttcg atcagcatcc gggacgcccc acatcgtgca
     8041 aggccgaact ccggcagccg gtgatgcggt gggcggcggg cacctcttgt ccgccggatg
     8101 ggccgctacc gccgaggtga gggggcgccc acggggccgt cggtcaccga tgtcatgggc
     8161 gcgaggcggc gtcgatgacc tcgtcgaggg tggcttgcga gcgacgcagg tccgcgatgg
     8221 tgcgatggat gcgctcgcgt tcagccagca gttcctgcac cagccacggt gtggcggtga
     8281 ccgctgggcc gccgtcgtgg tcacgtatgc agggcagcag ttgggcgatc ttcttgctgc
     8341 acaggccggc ggcgaacagt tcctggatgc ggatgacccg gtccacggcg cgctccggat
     8401 agtcccggtg gccgccgggc gtccgctcgg acgcgagcaa tccctgttgt tcgtagtagc
     8461 gcagcgaacg ctcgctcacg ccggtgcggc gggccaactc accgatccgc atcacgcatc
     8521 tcccctcgcg gacttgaact tgacatcagt gtcagattct acggtttgcg catgatgaag
     8581 ctcctgacgc ccttcacctc agcggaactg accctctcca accgcatcgt gatggccccc
     8641 atgacgcgct tccgcgccga agaggacggc accccgctac cgatcgtcgc cgactactac
     8701 cgccagaggg ccggcgccgg cctcatcgtc accgagggca tctggcccag cctccgcggc
     8761 cagagcggct ggcgcatccc gggcctggag tccgaacgac acgtgtccgc ctggcagcac
     8821 gtcaccgagg cagtgcacga cgccggcggc cggatcttcg cccagctgat gcacggcggc
     8881 cgtcaagggc acccacgctc ccgtgtcctc ggcgacatcc cggccggtcc ctccgccgtc
     8941 cccgtgcccg gtcccgtaca cgtgaaggac ggcaaggcag acccggtcat accgcgtgcg
     9001 atgacgcacg acgacatccg cacggccatc gccgaccacg tcgccgccgc ccgcaacgcg
     9061 atccgggccg gcttcgacgg cgtcgaactg cacggcgcga acagctacct catccaccag
     9121 ttcctggccg acaacaccaa cctgcgcacc gacgcctacg gcggcgacat ctccggccgc
     9181 atccgcttcc cgctggaact ggtacaggcc gtcacggaca cagtcggcgc cggccggctc
     9241 ggcctgcgcc tctcgccggg caacccccag ttcggcatgg aagaggccga cccggccccg
     9301 gtctatcgcg cgctcctcgc ccgcctcgac ggcctcggcc tggcctacct ccacctcacc
     9361 gacgacgacc gctaccccgc cctcgccgac ctgcgcccgc gctggcacgg cacactcatc
     9421 gccaacgtcg gcgagaaccg cgccccgacc acccgcgagg ccggcgaggc ggtgctcgca
     9481 tcggggcgcg cggacctggt ctcgtacggg cgcctgttca tcagcaaccc cgacctgccg
     9541 caccgcttcg cagccggcct gccgctgaac acgcacatcg accaatcagc gctgtacggt
     9601 cacggcgccg cgggctacac ccactacccg gcatggcagg agagttccag gccgatcatg
     9661 cggtcggttg tccccagcag cccgggacgc tgactccgcg cccgagtggc ggggccccgc
     9721 gtccagccgt cggcgtcgga cgccgtgtgc tgcgcgtcgg ccgtgtcctt gtactacggc
     9781 aacgaggtcc tcacctgcct gggcatgtgg ctgttcggtc aggcgctgcc gggcaccctc
     9841 aggaattcga ggtgcccggc agcgtctgcg cggtgggggc gcggtcacga cccccgcacg
     9901 atcgccctgg tcgctacgcg gagttgatct ggtggtgttg aatgcgagct ggcggtgtct
     9961 gtcgacggcc gtcctgtttg acggggttcc agggagagca atgactgctg acaacgcggc
    10021 cggtgtacac gagcggctcg ccggatacca ggagcgcttc aacgggttgt tcgcgaacta
    10081 cttcgactcg gtcgccgagc aggggccgcc gcgcaatgcg ttcgtgcccg aggcgctgga
    10141 gctggtgcgg gacatgtcgc tgcggggcgg gaagcggcta cgggtcgcgc tgctgtacga
    10201 ggcggcgcgc ctggtggctc ccgctgccgt gcccgggctg gacgaggccg cgctcagcat
    10261 tgagttgctg cagacgcacg ggctgatcca cgacgacatc atcgacgact ccccggtacg
    10321 ccggggggcg ccgtcggtgt actacgccta ccgcgagcgg ttccccggcc gtccgcagac
    10381 ggcgttgggt ctggccgtcc tggccgggga cctggcggcg tttctgtcgg tccaggtgct
    10441 gctgaccgcg ccggttcccc gcgagctgcg gcaggcgatg gcggccgtac aggcgacggc
    10501 gggggcggac acggtccgcg ggcaattcct cgacctggag cgggacttcg gcccgatgcc
    10561 cgaccgcgag gtgctggaca ccgtgtccga gtacaagagc gcccggtact cggtgctggc
    10621 cccgttgcag ctgggtctgc tcgcggcggg cgcggacccg gccgcccatg agaacgaact
    10681 ggcccggtac gcccgactgc tcggggtgag cgggcagatg cgcgacgact acctcgacct
    10741 gttcgcggac gcgggcacgg tcggcaagcc ggccggatcg gatcttcgcg agggccgccg
    10801 cagctacgcg gtgtgcgcgc tgctggcagc gacgagcggt gcggagcggg cggtcgtgga
    10861 gtcggcgctc gccggccccg gctgcccgcc ggagaccgtc gaacggattc aggacatcgc
    10921 ccggcgccac ggcgtcgaca ccgagctgct cgccgagatc cgccgctgtg cccaggaggc
    10981 ggccgccgtc gcggccaact ggcgggggcg gtggcgggac gaagccgtcg agttcttcga
    11041 acagctgccg ctgtggggcg tgctgcgcac ccagtgatct tccgtgcggt tcggcgctgg
    11101 gtgagcgtgg tgaagtccca tccgccgatc gcggcaccga ccacgacctg ggcgcggtcg
    11161 tcgcagccgc atggccgcga gcacacaacc agtgaaggcc cggtgggatc accgggcctt
    11221 caccttcgag tagcggggac aggatttgaa cctgcgacct ctgggttatg agcccagcga
    11281 gctaccgagc tgctccaccc cgcgacggca cactgaacct tacggcaccg acctggatcg
    11341 gccgaatcga catccgtccc ggcccgacct gatccgtatg cgtcggcgag gaggtccggt
    11401 cgggctccag gcccgcactg atctttctgg cggctttggg tgcttgtctc ggcaccgtcc
    11461 tggttcgtct cgtgccgcat cagacaacgt acgccctgta tggcgctcat cggcagccgt
    11521 ggcaagcagg gggatcgtga atgtcccgac gccagatggg acgtgcgtgc caggatcgac
    11581 cgtatgactt ccgcttccag aagctctgac gtgcacgcag gcatcccggc agcctcgcag
    11641 ccgccgtgga tccgtcctgt cccggagggt tccgccgggc ccggcgggca ggccgtgccc
    11701 aacgactacg acagcttcgc cgaggcgtac tcggcccaga acgaaaccag cctcttcaac
    11761 gcgcactacg agcggcctgc gatgctggac ctggccgggg acgtggccgg ccgacggatc
    11821 ctggacgccg gctgcggctc cggccccctg tccgcggcgc tgcgcgaccg gggcgcgatc
    11881 gtgaccggct tcgactccag caccaagatg ctggagctgg ccaggaagcg gctcggcgac
    11941 gacgcggccc tgcacctcgc cgatctgggc agcccgctgc cgttccccga tgccgcgttc
    12001 gacgacgtcg tcgcgtccct ggtcctgcac tatctggagg actggacggc accgctggcc
    12061 gaactgcggc gcgtgctgac tcccggcggc cggctgatcg tgtccgttga tcacccctcc
    12121 atcggcctcg tgcagccggg caccgactac ttcgcgacgt accagcactc cgaggaatgg
    12181 accctcggcg ggcacaccgc cctgatgacc ttctggcatc ggccgctgca cgcgatgacc
    12241 gacgccttca ccgcggccgg cttccggatc aacgtcatca gcgaaccgct ccccgcaccg
    12301 ggcgcccgcg agctgttccc cgacatcttc gtggacaagc cctcgggggc cttcgtgtgc
    12361 ttcctgttct tcgtcctgca ggccgactga cgtcgtatca ggccacgttg gccttggcga
    12421 cgacggcctg gaggcggcgg tcgtcggcat ggcggttccg ccggatcagg tagcggcgga
    12481 tcatgctgcc ctgccctgta tggctggcgt ggtcggtgcc gtccagggcg aagtagcgcg
    12541 gggcggtgaa ctgggactcg atgcggttga gccaggagga gttggtcggg gttgaaacga
    12601 gacgccctct tcgcggacca ggacccgaag accctcgtgg ctgatgccgt caaccacccc
    12661 ctcggcgacc aggaagtcgg ccagctcggc cgggctccag gtcgagaacg gcaggccgtg
    12721 cccggtcggc ttcgacttgg cgatcttcct gatctcccac ctgcaacacg tccgtgttcg
    12781 gctcgggccc ggaggacatc gactacgtca ggggtgtgat gcaggtccgt cgccaagttc
    12841 aagcgatcca cggcacgttg tcttcggcac ggccgaaggg ggccaggacg cgtaccgtcg
    12901 acatgcccct cctcggtggc cggagagttg aagcgtcacg tggcagcgtt cccgccggta
    12961 gaggtggagc ttccgtgggg gaagccggag gcggacgggc agcggaggaa ggtgtctcct
    13021 ctgctcacca cgcgattcgg caacgcggtt gggcatgcca gtcgaactcc ccggattgtc
    13081 cccagtgctg agagccggcg tccctgatac ctccgtcggg tgcggtctga ccgggggacg
    13141 gaagacggcc cgacggtgtg gccgtcgggc cggggtgaag ccactcgccc ctcagcttcc
    13201 ggcagacgtc agccgtcgtt ctccgaggac ggaaggtacg cgcccggcac gtcctgcggc
    13261 gcgaagatct tgttctcgcc cgggtacggc ctgttccagt tgtgcgtctc gtaccaggtg
    13321 aggtggttca tctgggcggg gttggcgtag tcggggacgg cgtgggggcc ggtcagccgc
    13381 tgcttggact tccatttgtc ccaggttgcc gccaggtcct gcttgtccgc cggtaccgtc
    13441 gcgggcgaga cggccgctgc cctggggctc tgcgctgccg ggttgtccga gccgcagggc
    13501 ggctgggtct tcagaccgtc ggtgaggggg acgcggttgg gctgtgcctt gaacggggcg
    13561 gtgtccgggt gggcggtgaa ggcgccgctc atggggctgg ccgcgctgtc cttctggttc
    13621 atcgggtgga tcccgaggat ctgctcgatg gtccggatca tcgtgatctg ggtgtagtag
    13681 tggctgtcgg tcctgccgtg ctgtgcccag gggctgatga tctggatcgg ggcccggtgc
    13741 ccgtccacgt ggtcgaggcc cgcctgggag tcgtcctcga cgacgaagat ggccgagtcc
    13801 ttccagtact tgctgtgcga gatcttgtcg accatcttgc cgaccgcgag gtcgttgtcc
    13861 gcgacctggg cggacgggct cgcgggacca ccggtgtggt cgttggagaa ccagaacatg
    13921 ttcaggttcg ccggcccgtt cttctcgaag tcctgcttcc agacctggta cttgtagata
    13981 tccgggacgt cgaggtcgaa catcgggaag ccgggcaccg acacgtcgtt gagcgagggg
    14041 atcgccgacc cggtcttgat ggggtaggcc gtgggcctcc cggttgcgtc catggtcctg
    14101 gcgtcgcagt acaggttctg ccaggacgct ccggacggct tgctctccac cgactggaac
    14161 tcaccgaagt ccttgacgga cctgcctgca gcctgcgcac cggtccacag gaaaccggac
    14221 ttctggtggc cgagcgcgtc gttctcggtg tcgtagctgc gctggtactc gccggccgag
    14281 gactcggtgt actccggatt gtcgctctgc atcagccagt tgtgaccttc ggcagagttg
    14341 gtgccgatgt cgtaggtgtt gtcgtacagc ccgaactgct tggccagcgc gtgctggttc
    14401 ggcgtcacgt tctcgccgaa ctgcgtcagc ttcggatcgc cgttgccctg cgggaggtcg
    14461 ccgaagacct ggtcgtaggt ccggttctcc ttgacgatca ggaagacgtg cttgatcgtc
    14521 gaggggtcgc cgagccgctt cgggaccgct gtcggcttcg cgtggctcgt gccgtcggtc
    14581 ctcttgaccg agtcgcccgt ccagccgttc tgcttgaaga ccttggccgt ctcggacctg
    14641 atgacgctgt cgtcgggcag ggtgaaccgc tgcaggctgg aggtggtgtc gtgggtgccg
    14701 tgcgcaccgc ttgcggtggg gcggcgggcg tcgattccac gggagttgga gaccagcacc
    14761 tgcttgccga cggtggcgat ctccgagggg aagtagtccg tggggagcag gccgacgtag
    14821 ctgaccggct cctgcgggct cttgtacttg tatacggcga ccgcgttggc gcggccgagc
    14881 gtcaccagca gatgaccgtc gtcggtgagt gtcaccgcgt tgggctcgta acccaccgac
    14941 gcctccggcc acggacgggt ggcgatggtc tgcacgacct tgtcgccggt ggtgctgatg
    15001 accgacacgt cgttggtggc agtgttggtg acgaacagtg ccccgccctt ggcgtacagg
    15061 gcggtcgggt gcagaccgac gtcgatgctc ttgacggcgg cacccggctt cgccaggtcg
    15121 atgacgctga ccgtgccggt ggtggtggca ccggtcttcg ggtcggcggg cacctgggtg
    15181 ccgtaggagt tgatcgtggg ctcgccgggc ttggccggac ggccgccctc gttgctgacg
    15241 tagagcttgt ggccgacctt gaccatgtcc cgcggggcgt tgcccacggc ccagctgtgc
    15301 ttgacggcac cggtcgccgc atcgagggcg accaccttgt tctggccgtt gaccgcggcg
    15361 tacacggtgg agccgtcgga ggagaacacc ggctcgccca ccagcgcgtg cttggtgccg
    15421 tccgccggga tcttgatgaa cgtcgggttg ctgacgctgc cgtccgggtt cactgtgaac
    15481 ttggtgtagc cgtcggtctg gcccagccac agctgcttgc cgtcgggcga gtacgtgggg
    15541 ccttcctggc ccacggagtt gctgctgatg cgcggggtcg acgaagcgga ggcgccgacg
    15601 agctgctgca ccttccagtt cttgcggtcg acgatggcca gcgccgcccc gccgtcggtg
    15661 agcgaggccg cgacgtgggt gccgtccggg ctgaccgagg acgacatgat cttgccgtcg
    15721 tcgatgacga gacggtcgcc gtacggggcg atgtactggt cgctggagac gacctggccg
    15781 tcagccgtct tctgaccgac tcgggcggtg ccgaactggt gcgtctgggc ataaccgatg
    15841 ccggcggtgg cggcgaggac gaccgcggtg gccgtggcca gggtgccgcg gcggctgaaa
    15901 cgtctgcgga gattgccggc acggtcgttc gcgtcatgcc ggcggcggcg tatgacctgc
    15961 atggagttat cccttcgagg tggcgagcag cgcgacattg ccgtcgaact gccacagcgg
    16021 gttgggtgcg tcgccctgcg gggtccgcac caggaagtag ccgttgactt ccttcggtcc
    16081 atcgccatcg gccatgaacc gcccgtccgg ggtcacgtcg agctgataga tggcctggcc
    16141 ggcggcgtcg acgccgggga ggtgccagga gaccacgcag cgccagtcgt tgcccgcccc
    16201 ctgcgcggca gtctggaggc tgcccttggt gcacgtcgcc tcggctttca gctgggcttc
    16261 ggtgacgtgg ggccggtgga gctgctcggt ctgcatgcgg tacaggtggg cgaatgccgt
    16321 ggcgaccgag cgctgcacct tgtcctgctc gatcccggag ccggtggccg tggccgtggc
    16381 cgacgtggtg aggaccgcca ccgtcacggc gaccagcccg gccagcggca ggaatccgac
    16441 ggtgaccgtg cggcgccccg agccgtcgta gctcaggttc gtgaagtcgc gccgcaggaa
    16501 cagcaggtag gccagtgccg tcgccagcac ggcccacgcc aggctgacac cggtgccgat
    16561 caggagcggg gcgagctggg ccgggccggt gaacagaccg ttccaggcga tgaaggcgta
    16621 gctgggcagg gcgaggcgga cggcgaccgg cagtggcatc atctgtgcga gctgcatcgc
    16681 gagggcgacg aggacgggca gcagcagtcc catcggggag cgccccagcg cgacggaccc
    16741 gagcagtccg atcccggcga gggagagggt cggagcgagg acgcagaccc aggcgagcag
    16801 gaccttgacg gcggcgtccg ccggcgtcag caggtggccg tcgaggccga ccagcggctg
    16861 gttgccgacc gccacgaccc caccggccgc gctggaacag gccagcccgg ccacgagcag
    16921 cagcaggacg gtgaggctgg cgaacgcctt tgcggcgaag atccgcctgg gcgaccggac
    16981 cgccaccagc aggtggcgcc aggtgccgag tcggtcctcg gcggcgaaca cgtcgccggc
    17041 gaccaccgag gtcagcagcg gaagcgccca ggtgcccgcg aaaccgagcg tcaccagcgg
    17101 tccggcccat ccggtggcgt gcatccagcg gccgaaaagg gtgtcgacgg ggagcgtgct
    17161 ctgttggctc accgcggcga cgaagagcgc cggcgcgatc cagcaggcga gaaccagcag
    17221 gcggatccgc cactgcgaga ccagcttgac cagctcgaag cggtagccac gcgccaccga
    17281 ggcgcggcgg gtaccggcac cgtggggccg ggcttgggcg tgcgtgaggg gcgcgttcat
    17341 cgcccggcct cctcaggttc ggtgagggcg aggaacgctg cttcgagcgg cgacaccacg
    17401 ggggagagct cgcgtaccgc gatgcccgcc cgcaccagcc gcaccaccag ttcgtcgagg
    17461 gcaggcacct gcgcgcgcac gacgagcacc tgcgcgtcgt gccgtgcccc ggcgtcgtcg
    17521 gcgaggcgga tcccggctgt ttcggcggcc agtcggcggg cggcgtgcgc gtcggaggtg
    17581 cgtacgcggt agtcgagttc ccgctcctcg gcggccagtt tgctcaacgg cccggagaag
    17641 accacccgcc cggcggcgag gatgctgacg tcggagcaca gggcctcgac gtcgtccatg
    17701 cggtgactgg agagcacgac gccggtgccg tccgtcgcga gccgggtcag gacaccgtgc
    17761 acgtgcttct tgccggccgg gtccaggccg ttggacggct cgtcgagcac gagcagccgg
    17821 ggcttggtga gcagcgccgc ggccagcccc aaccgctgtc gcatgccgag ggagaagccg
    17881 ctcgcccggt cgtcggcgac atcggtgagc ccgacctgcg caagtgcgtc gtcgatcgcc
    17941 gtggtccgcg cgtcgtcacc gcggagagcg gccagcgcgg cgaggttctg ccgggcggtg
    18001 agcgaggggt agagaccggg tccgtccacg aagcccgcga caccgtcggg agcgtcgagc
    18061 gcccgcccga ccggcgtacc caggatctgg aggctgccgc tgtcggcgac ggccagaccc
    18121 agcagaaggc cgagcaaggt cgtcttgccg gcgccgttcg gtccgaccag gccgtgaatc
    18181 tgcccctgcg tcacgtccag gtcgacgccg tcgagcgcga cgacatcgcc gaaccacttg
    18241 gtgatcccgc gagcccggac tgcgaggagt gcgtccatga gtcccttcct tcgagagcct
    18301 caaggaccgt agatgcggtg cgcggcaacg ttcaggagca gtcagctgaa tgctcaagaa
    18361 acggttgacg accggtatgc gccgtgacga agcccgggag tcgccccccc cacgggccgg
    18421 tgtggcggac gatgaccgca tgcgccgcgg tcgccttcgc cacgctcgcc gtatcggtgt
    18481 ctccgctgac gaccggaacg gcccatgcgg acactcccgc accggcgggc ctgtccctgt
    18541 cgccgcggtt gacccaggcg gacggcctcg cgccgtccct ggatccggcg aaggactcgc
    18601 ccgactacgg gaccgagagc gtcgtcaaca agacgtcaga tggcgaactg gagcatgtag
    18661 cccaacggtg acggaagctt cctgatccgc aacgacacga cgcagaagtg cctcgactcc
    18721 aacaccgaca acaaccctct cgtcgagccg gggtactgcg accaggccaa caccaggcag
    18781 aactggtatc cgcaaccctc ggacggtggc ggcggctact acctgatccg gaagccaaca
    18841 ccgacaagtg cagggacgtg ctcgggggag cggcaacgac ggcacgacgg tcggtctctc
    18901 cggcccaggc acacgaccgg agcatcaccg acggcagcct gagcaggggc ggctaccgga
    18961 tacacaccac cttcgacagg aaaccgaccg cggaactggc cggcgccgtc gccagggtcg
    19021 gtgcgcaacg cctcgacccc gcccaccggt cggccgaccg ggacgtccac gtcggagccg
    19081 cctcggccga acccaccacc ggcaggatcg tcgcgatgtc ggcgatcggg tggtgtcggt
    19141 gtatgcgggg gtcgagcggc ggatgatcgg ggttagggcg tgtggagatc aacgcgttga
    19201 tctccacacg ccctacgatg cttccctcgc gaagtgaccg gcggcacggc gagtgatgcc
    19261 tctggtgttc ccggagctgc gccgggcgac tataggccgt cgtgagaatt cacatgcgcc
    19321 tggtagatga tcagtcccgt gtactgtgcc gcctgctcga acgtctcaat gcggaccgct
    19381 tgtgtgtcgt tgccgttccg tgatgccgga ccgatctgca ccggcgcggc gtgggcatgt
    19441 tggctgacgt catggacgaa gtccgaaagg cggccccagt tggtctccag ttcctgctgc
    19501 agtggagtca gctggtaagg ggtcccagtg aggaaggcgt tggccacgcc ggtcccgatg
    19561 gggttgaagc gcacggcctc cgaggtgatt gtcaccatcc tcaacacggc ccgagcggta
    19621 tcccgtacac cgttcctgtt gttcaggttg acgccgtcgt gcagggtctg cacggaactg
    19681 tcgatgctgt tcgcggtgat ctccatggca ccgcgtgatt cccatccggc tgccctttgc
    19741 agagccgtgt agctctcacc gaacggcaga gtgatgggct ggtgctcgcc gctccacgcc
    19801 agccttctcc ccagattggt cccgttcaac tggtacagac gaccggtgtc gtccgaactc
    19861 cagcccaaaa agtacatgtt ggacgcgtta aagtagatcg tgacggactc gacctgatgc
    19921 tgcctgccgt ctccgccctc gcccaagtcc ctggtgacat tcagggcgac gagttggttt
    19981 cggtcgtgtg tggtctcttg gacattgttc cgaaaggagt gcccgacggc tgtccggagc
    20041 tgttggagca tcgccaggta ccggttgctg tcgtgggtgt cgacccagtg gacagttgaa
    20101 taggaaggac ggttggcggc gcggttggtg acggttgcgc tgtccatgtg cacgggtgtg
    20161 gccgcagcgg ttccccctgc gagcatgacg gctgcgattg cggcacttat gccgattccc
    20221 cacttcataa tcgctgtcct cccattgctg tgatctctcg tctcgctctt ggacgacaat
    20281 cagcttcaac ggtcgggttg gtgttgcgct aacggacggc taacgcggtg tagcggcgta
    20341 cggcagtgag ctcgccgacg acgacatgac tgtcttcatc cctggcattc agcgggcctg
    20401 ccggcaggtt tcgtgagcaa tgctcatgac ctgtggatca ctcctgacgg aaggaggcgt
    20461 accttcctga tggatcgatc gacaggtcat cgagcaaggc cgacgttgca gcgtcggtcg
    20521 ggaaggcacg tccgtgcttg cggtagtcaa cgaggacggc accacgccaa gcggcagttc
    20581 gctgctggat gaggtcgttc gggaaggcgc acggcggatg ctggccgccg cgcttgaggt
    20641 cgaagtcaac gcctgcatag ccgagttggc cgatgagcgc gacgacaagg ggcgccgcct
    20701 ggtggtctgc aatggctatc accagccccg gaaggtcacc accgcggccg gcgtggtcga
    20761 ggtcaaggcg ccgcgggtga acgacaagcg ggtcgacgag gccacgggcg agcgcaagcg
    20821 gttctcgtcc gcgatcctgc cgccgtggtg ccgcaagtcc ccgaagatca gcgaggtgct
    20881 gcccctgctc tacctgcacg gcctgtcctc cggcgacttc gtgcccgccc tggagcagtt
    20941 cctcggctcc tccgccgggc tctcggcggc tacggtcacc cggctgacga cgcagtggca
    21001 ggccgaccac gccgccttca tggaccgcga cctcgcggag gtcgactacg tctacgtatg
    21061 ggccgacggc atccacc
//
