LOCUS       NZ_CP054019            13500 bp    DNA     linear   CON 28-JAN-2024
DEFINITION  Streptomyces sp. A1-5 chromosome.
ACCESSION   NZ_CP054019
VERSION     NZ_CP054019.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. A1-5
  ORGANISM  Streptomyces sp. A1-5
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9459690)
  AUTHORS   Dashti,Y., Sumang,F.A.M., de los Santos,E.L.C., Alcantara,E.P. and
            Challis,G.L.
  TITLE     Structural revision and biosynthesis of polyketides FXJ15321 and
            FXJ15322 from Streptomyces sp. A1-5
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9459690)
  AUTHORS   de los Santos,E.L.C.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAY-2020) Warwick Integrative Synthetic Biology
            Centre, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL,
            United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: JUN-2019
            Assembly Method                   :: Flye v. 2.4.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology :: Oxford Nanopore MiniION; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/28/2024 04:28:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,328
            CDSs (total)                      :: 8,230
            Genes (coding)                    :: 7,847
            CDSs (with protein)               :: 7,847
            Genes (RNA)                       :: 98
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 74
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 383
            CDSs (without protein)            :: 383
            Pseudo Genes (ambiguous residues) :: 0 of 383
            Pseudo Genes (frameshifted)       :: 156 of 383
            Pseudo Genes (incomplete)         :: 280 of 383
            Pseudo Genes (internal stop)      :: 26 of 383
            Pseudo Genes (multiple problems)  :: 73 of 383
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:08:01
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7998834
            Orig. end                         :: 8012334
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP054019.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Philippine National
            Collection of Microorganisms.
FEATURES             Location/Qualifiers
     region          1..13500
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="aminopolycarboxylic-acid"
                     /region_number="31"
                     /rules="(AesA and AesB and AesC)"
                     /tool="antismash"
     cand_cluster    1..13500
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(AesA and AesB and AesC)"
                     /kind="single"
                     /product="aminopolycarboxylic-acid"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..13500
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:8500](+)"
                     /cutoff="10000"
                     /detection_rule="(AesA and AesB and AesC)"
                     /neighbourhood="5000"
                     /product="aminopolycarboxylic-acid"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..8500
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(AesA and AesB and AesC)"
                     /neighbourhood="5000"
                     /product="aminopolycarboxylic-acid"
                     /protocluster_number="1"
     gene            complement(321..1199)
                     /locus_tag="HRD51_RS35130"
                     /old_locus_tag="HRD51_34695"
     CDS             complement(321..1199)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1085:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014173875.1"
                     /locus_tag="HRD51_RS35130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_34695"
                     /product="ABC transporter permease subunit"
                     /protein_id="WP_235095124.1"
                     /transl_table=11
                     /translation="MSTTAVLDRTRLRGPRTLPRVAPALLLTVLALLGPLLAPHPADQP
                     VTSPYAPPGDGAPLGGDQLGRDVLSRLLHGGSALIGSALAVAVVVTALATLLGCLAALS
                     PALGRVIEAVADVAILLPPVLGIMLLSLAWPGGGRPAVTVAAIALGTPYAVRIVAGAAA
                     PLAASGFVEAAAAGGERLFHLALREILPHLRATVLALFGLRFVEAVYVISMAGFLQLGP
                     QPPTADWALMIRENASGILLDPWSVVAPALAIGLLAISVNLAADTVAPKAGRRSGPRAG
                     RGAGRRAVSRR"
     gene            complement(1196..2206)
                     /locus_tag="HRD51_RS35135"
                     /old_locus_tag="HRD51_34700"
     CDS             complement(1196..2206)
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1118:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020548824.1"
                     /locus_tag="HRD51_RS35135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_34700"
                     /product="ABC transporter permease"
                     /protein_id="WP_328285891.1"
                     /transl_table=11
                     /translation="MAGAVSAPPDDRTARPGPPRGTGAGRAAARIGMLLGKRVLMLAVL
                     LAVVFAAVQLLPGDAASATSERGEGAAGVAARRHLLGLDRPLWERFQQWMTGLPTGDLG
                     TSARGQKVTDLLAAPFPNTLLLGGAAFVLTMAAALVLGCWAAARPGGRLDRAIGLGSTA
                     TFALPEFIVAVGLLLVLSLWTGWLPAVTLTDGGGAPADWTMLVMPVLALAVPQTGWNTR
                     IVRAALADQERTPHVAAAHLDGLPRRQVLLRHALPGALPTIAIGAATSTGMLLGGAVVV
                     ETLFNYPGIGTVLAGALADRDTPVIAGVVACAGAAVSLVLFLADLIRYRTLGDRS"
     gene            complement(2191..3711)
                     /locus_tag="HRD51_RS35140"
                     /old_locus_tag="HRD51_34705"
     CDS             complement(2191..3711)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009996696.1"
                     /locus_tag="HRD51_RS35140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_34705"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_235095125.1"
                     /transl_table=11
                     /translation="MSGGLGAAALLSGCGGGPGADSDGDGPDGPPRKGGTLRVGALGRA
                     SAITRDPHGTQGNESDYLIIALVHDTLTAPGRKDNTVGRLATSWQASEDLRTWRFRLAQ
                     GATFHDGTPVTAEDAVWSLRRLRNTPAGAARLPGIQAHRITAEGKDTVVLVSDRPNAEL
                     PLLTRLTTFVLKKDTPEKELAQAPGTGPFRLDRYRGGNARLVRNDHWHGGEIHLDAIEV
                     TMFESPQAMANAMLAGQIDLASNAGAVAARTAAGRQDIQVLRRPNDMAMPIVMRAADGP
                     FADPKVREAVKLIVDREAMVKQVLSGYGTVANDILGTGDPDYAKAVPQRHRDLARARRL
                     LGEARFDLSRTYELITTEDIAGLAESATLFAAQAREAGLKIKVTRQESGTFYARTWLKG
                     DLYTNYWGTNDSVVFFASKTMTTGAGQNEAGWSDPQFDAACAKVLGTADAARRRSALRA
                     LQQIEHDRSGYLLWGMADGIDLAARKVRNLPKLPGYGRVQLEHVWLAR"
     misc_feature    complement(3803..3821)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: medium, score: 28.57"
                     /tool="antismash"
     misc_feature    complement(3867..3880)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 19.61"
                     /tool="antismash"
     misc_feature    3868..3888
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 19.68"
                     /tool="antismash"
     misc_feature    complement(3872..3890)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: medium, score: 27.57"
                     /tool="antismash"
     gene            4012..5004
                     /locus_tag="HRD51_RS35145"
                     /old_locus_tag="HRD51_34710"
     CDS             4012..5004
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: TauD (132-300). E-value: 2.2e-11. Score:
                     35.9. Matches aSDomain:
                     nrpspksdomains_HRD51_RS35145_TauD.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091641.1"
                     /locus_tag="HRD51_RS35145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_34710"
                     /product="TauD/TfdA family dioxygenase"
                     /protein_id="WP_235095126.1"
                     /sec_met_domain="TauD (E-value: 3.1e-09, bitscore: 35.9,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTGSAPVRLLDDASLTELRRAAEEILAAAGTSATSPELLAAVAR
                     SAAALGAPIRHACRPVDTDDGLFVLRALAVDDTGIGPTPGSWATAGDRAAVHDIALLLL
                     ATVMGNPLAWEGQQDGRFVHNIVPSSGHEQAQTGASSSVLLSPHTEDAFHPGRAHLLML
                     GCMRNHDAIATTAASIRKVRLGDEDLAVLARPEVPILPDDAYAEARGFDGRPPNVPTLW
                     ESEDGRTLRFDPAYTPLDEATPEYRAAYRRLSEQLAAVSTAVSLAPGEVLVVDNDLVVH
                     GRVPFRARYDGTDRWLKRASVRVPGRRTRPPAEATEHGYGQAAIEAHAA"
     aSDomain        4408..4911
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HRD51_RS35145_TauD.1"
                     /evalue="2.20E-11"
                     /label="HRD51_RS35145_TauD.1"
                     /locus_tag="HRD51_RS35145"
                     /protein_end="300"
                     /protein_start="132"
                     /score="35.9"
                     /tool="antismash"
                     /translation="EQAQTGASSSVLLSPHTEDAFHPGRAHLLMLGCMRNHDAIATTAA
                     SIRKVRLGDEDLAVLARPEVPILPDDAYAEARGFDGRPPNVPTLWESEDGRTLRFDPAY
                     TPLDEATPEYRAAYRRLSEQLAAVSTAVSLAPGEVLVVDNDLVVHGRVPFRARYDGTDR
                     WLKRA"
     gene            5001..6047
                     /locus_tag="HRD51_RS35150"
                     /old_locus_tag="HRD51_34715"
     CDS             5001..6047
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminopolycarboxylic-acid: AesA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1158: ornithine cyclodeaminase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018546196.1"
                     /locus_tag="HRD51_RS35150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_34715"
                     /product="ornithine cyclodeaminase family protein"
                     /protein_id="WP_235095127.1"
                     /sec_met_domain="AesA (E-value: 5.6e-161, bitscore: 533.5,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNHQQPLPEDLVTDRSTPVHDIPGRTLRALSTSDLAGIDITLADV
                     VETVEQAYRTLAAGASDNPRKLTVKPADGHSVGYAMLGRDGSREIVAVKTSYKHGLDKD
                     RGDQHYYTALTLYDDISGLPIAMMDCGRIGALRTPAVSALLARACARPGARTALVIGTG
                     TQGRLALPFLLTTLPDLDRLLLAGSHPDGIAAVRAELHRHFPDRDVELVTDLRAAAPSA
                     DIVVATAGGHTAAAVEADWLAPGALAVLVGHGLAPSTLHRADRVIATSEAQMRVTGTDM
                     ADAEGHLRPVDAELPRIIAGAAVGRRTADERIFGYNSGLVVTDIALGHRFAQLALAQGR
                     GTQVPLWQ"
     gene            6038..7441
                     /locus_tag="HRD51_RS35155"
                     /old_locus_tag="HRD51_34720"
     CDS             6038..7441
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminopolycarboxylic-acid: AesB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Orn_Arg_deC_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1264: diaminopimelate decarboxylase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010987018.1"
                     /locus_tag="HRD51_RS35155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_34720"
                     /product="Y4yA family PLP-dependent enzyme"
                     /protein_id="WP_235095128.1"
                     /sec_met_domain="AesB (E-value: 6.4e-186, bitscore: 616.7,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Orn_Arg_deC_N (E-value: 4.2e-22, bitscore:
                     77.6, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVTGDRTPAPSAVPFLPALPDPGTDAVLDSGLLPELSHAFGGPF
                     HFLLPDRFDANVAAFRTALAETGVDGRIHYAKKANKAAVWIERCAATGTGVDVASLGEL
                     REALGNGVRGERVVVTGPAKSDQLLRVAVLQACLIAVDSLDELDRLLHHAPPGAPRAPR
                     ILLRLLPPQQPGSRFGMTGAELDTALARCVAAGDAVRMEGFSFHLSGYAIPPRVELAAA
                     LLDRCLAARTMGLQADRISIGGGFAVDYCAPADWYAFLTAQRPGHYHADRTFDPADFYP
                     YHSPVAGADALRAVLAGTTATGTDSGPRTLADRLRDTGTLLLLEPGRALLDGAGASVFR
                     IQGVKDRAGYAIVTVDGTSLSLSEQWFNSEFLPQPVLVGADGRASGDAAHPACVGGVSC
                     LESDLLTWRKVPFPRRPQPGDLLVYPNTAGYQMDSNESPFHELPLPPKVVLDRTDGRPR
                     WRLDRRPAP"
     gene            7475..8500
                     /locus_tag="HRD51_RS35160"
                     /old_locus_tag="HRD51_34725"
     CDS             7475..8500
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /GO_process="GO:0006535 - cysteine biosynthetic process
                     from serine [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aminopolycarboxylic-acid: AesC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006138038.1"
                     /locus_tag="HRD51_RS35160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_34725"
                     /product="cysteine synthase family protein"
                     /protein_id="WP_205368706.1"
                     /sec_met_domain="AesC (E-value: 1.5e-171, bitscore: 568.9,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="PALP (E-value: 7.5e-57, bitscore: 191.9,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNEALSRPAVVSRVSELVGCTPLLELCRTENGSRLLLKLEMFNPT
                     GSAKIRMARQMVLDAEARGALRPGGRIVESTSGNTGLGLAVIAAERGYTFTAVVDRHAS
                     ADKLRTMRALGTELVYVDDDGSEDLATAAREELAEELARGRDNTVFTEQHNNPSNGVGY
                     HPVAHELHQALDGRLDLLIGAVGTGGALCGTAGELRTLIPDVTTIGVEPKGSIAFGGPA
                     HDYYQSGTGTPEGAEIGALVDFALIDEGVKVGDVEAFATARAVARTGLLIGGSAGGVVH
                     EALRRLPSLPPGTTVVALVNDGGEKYLDTVFDDGWLAARGLLAPDVEREIDERLSKLRR
                     N"
     gene            8516..9928
                     /locus_tag="HRD51_RS35165"
                     /old_locus_tag="HRD51_34730"
     CDS             8516..9928
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0042910 - xenobiotic transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006855 - xenobiotic transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1086: MATE efflux
                     family protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998466.1"
                     /locus_tag="HRD51_RS35165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_34730"
                     /product="MATE family efflux transporter"
                     /protein_id="WP_235096185.1"
                     /transl_table=11
                     /translation="MPAPQPTTLLRDGRALAALAVPLVLTQLAQVALTTTDTVMMGFLG
                     ARDLAAGGLAIVLFNQLRTMGVGLVTSVGNRIAAAAAREEEGDAPGTDADVAAVRGIAR
                     AGMAVATLAGLAGAVLMVLIGQALTWFGQDAEIADRARPMLVALAPGLLPCLWFQAIRQ
                     FTVGLRRPQALLRITVASVAVNAGLNWVLVQGTWGLPRLGLPGIGVATSAVHLLSFLAL
                     YAAARRDPVLAPRLSLNAAGAAAATVRTLVGLGVPIAATYGSEAGFFSVTALMAGSFGS
                     AALAAHTAVNQLVYIVFQVAVGLSHAASINVSRELALGRTDSARRLKNTALACAAVVMA
                     VVAVVYLALPELVLRPFFDPGAAGDREALAIAGQLLFVIAVLQFFDCAQNIGVGLLRGL
                     DDTRSGFRITLVGYWLVGLPAAWALGYAAGLHTLGIWLGLLAGLGTTALLLLRRYGTAL
                     RARDTAAPAEAA"
     gene            complement(9962..10849)
                     /locus_tag="HRD51_RS35170"
                     /old_locus_tag="HRD51_34735"
     CDS             complement(9962..10849)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543160.1"
                     /locus_tag="HRD51_RS35170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_34735"
                     /product="phenylalanine 4-monooxygenase"
                     /protein_id="WP_235095129.1"
                     /transl_table=11
                     /translation="MSTVRKQTPVSVEGRLGRANEHPGRHDQDYRRRRDALAARAENHR
                     VGAPYEDVAYTEDEHRTWRTVHDALAPAHRAHACREVLAAGEAADIPAEQIPQHAEITP
                     GLRTRTGFSLTLAGGVVPNERFLGAMEDGYFHAVQFVRHPAVPLYTPEPDVLHDVFGHG
                     IHLSSPAIAELYRVIGRAANRVRTAEALDILSRVYWYTLEYGLITESGGPKAFGAALLS
                     SYGEIAAHEVREVRELDLCAAASTQYRISCYQSVLFAARSFAHLEDAIGGFCAEFDDDT
                     GNRLGLPSLSRDRQ"
     misc_feature    10989..11006
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.5"
                     /tool="antismash"
     misc_feature    11001..11010
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.67"
                     /tool="antismash"
     gene            11121..12206
                     /locus_tag="HRD51_RS35175"
                     /old_locus_tag="HRD51_34740"
     CDS             11121..12206
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1205: ABC
                     transporter, carbohydrate uptake"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018536964.1"
                     /locus_tag="HRD51_RS35175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_34740"
                     /product="substrate-binding domain-containing protein"
                     /protein_id="WP_235096186.1"
                     /transl_table=11
                     /translation="MNATICRRVVVSALTLSLAAPLAACGSDHQEAPEGKDHIGLLLPE
                     NKSTRYENFDRRIISRRIASLCLECKVDYGNAESSAETQRTQFESLVKKGVKVIVLDPV
                     DARAAKDWVDSAARQGVQVVAYDRLAEGNVTAYVSYDNDKIGRLQGEGILTALGSRAAT
                     ADVVMFNGSPGDPNAPSFKKGAHAVLDGKVHKVVYEKDVPEWSEATAKKDMTDVINSRG
                     PHGFDAVYSANDGMAGGIAAALKAGGVKNVPVGGQDAELPALQRLLDGTQAFTVYKEVR
                     PEAETAAEIAFRLLRGQSIASLTSTTAANTSKSGIPAKLFNATLVTKANLKDTVVQNGA
                     VRADLLCTPAVAAECSSLGIQ"
     gene            complement(12339..12821)
                     /locus_tag="HRD51_RS35180"
                     /old_locus_tag="HRD51_34745"
     CDS             complement(12339..12821)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016641540.1"
                     /locus_tag="HRD51_RS35180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_34745"
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_039630452.1"
                     /transl_table=11
                     /translation="MAVDALDAKILRLLLEQPRTSVREYARVLGVARGTVQARLDRLER
                     DGVITAYGPRLSPAALDHPMLAFVHIEVTQGHLEEVAAALGEVPQIIEAFSTTGGGDLL
                     TRVVARDAAHLEDVIQRLISLPGVVRTRTEVVLRERVPHRMLPLVEAVGGAAAQPD"
ORIGIN
        1 gtgtccgagg acctcgaccg tgccggaggt gacctgcgcg ccgtggggca gggcgccgag
       61 cagcgcgcgc agcagggtgg tcttgccgga accggagggg ccggtgagcg cggtgatccg
      121 gccgggtcgc agggtgaggt gggcgccggc gagcagcacg ggcccgtcga cgaggcggat
      181 ctgaagatcg gtgacgcgga ccaggggcgg tgggacgggc tgttcgtcgg tcatggtcgg
      241 gccgggttcc tccgtgcgag tcctacggat ggcgagggga cgggagggcg gctcaccgtc
      301 tgctccatga cgagggcggc tcaccgcctg ctcaccgccc ggcgtcctgc cccgcgtccc
      361 gcccggggtc ccgaccggcg tcccgctttc ggcgccacgg tgtccgccgc gaggttgacg
      421 ctgatggcca gcaggccgat ggcgagcgcg ggagcgacca cggaccaggg gtcgagcagg
      481 atgccggagg cgttctcgcg gatcatcaac gcccagtctg cggtgggggg ttgggggccg
      541 agctggagga atccggccat cgagatgacg tacaccgcct cgacgaaccg cagtccgaac
      601 agggccagga cggtggcccg cagatggggc aggatctccc gcagcgccag gtggaacagc
      661 cgctcgccgc ctgccgcggc cgcctcgacg aagccggagg cggccagcgg cgcggcggcg
      721 ccggcgacga tccgcaccgc gtacggcgtg cccagggcga tcgccgcgac cgtcaccgcg
      781 ggccgtccgc cgccgggcca ggccagcgac agcagcatga tgcccagtac cggcggcagc
      841 aggatcgcga cgtcggcgac cgcctcgatc acccgcccca gcgcggggct gagcgcggcc
      901 aggcacccca gcagggtggc cagcgcggtg accaccaccg ccacggccag cgcgctgccg
      961 atcagcgcgc tgccgccgtg cagcagccgg ctcaggacgt cccggcccaa ctggtcgcca
     1021 ccgagcggcg cgccgtcgcc ggggggcgcg tacggggagg tgaccggctg gtcggcgggg
     1081 tgcggtgcga gcagcgggcc gagcagggcg aggacggtca gcagcagcgc cggggccacc
     1141 cggggcaggg tgcggggccc gcggagccgg gtgcggtcga ggacggctgt ggtgctcatg
     1201 accggtctcc cagggtgcgg taccggatca ggtcggcgag gaacagcacc aggctgaccg
     1261 cggcgccggc gcaggcgacc acgccggcga tgacgggggt gtcccggtcg gcgagggccc
     1321 cggccagcac cgtgccgatt cccgggtagt tgaacagtgt ctcgaccacg acggcgccgc
     1381 ccagcagcat gccggtggag gtggcggcgc cgatggcgat ggtcggcagg gcgcccggca
     1441 gcgcatgccg cagcagcacc tggcggcggg gcagaccgtc gaggtgggcg gcggccacgt
     1501 gcggggtgcg ctcctggtcg gcgagggcgg cccggacgat ccgggtgttc cagccggtct
     1561 gcgggacggc cagggcgagg acgggcatca ccagcatcgt ccagtcggcg ggggcgccgc
     1621 cgccgtcggt gagggtgacc gcgggcaacc agcccgtcca cagggacagc accagcaaca
     1681 ggccgaccgc gacgatgaat tcgggcaggg cgaaggtggc ggtggacccc aggccgatcg
     1741 cccggtccag ccgtccgccg ggccgggccg ccgcccaaca gccgagcacc agtgccgccg
     1801 ccatcgtcag gacgaaggcg gcgccgccga gcagcagggt gttggggaac ggcgcggcga
     1861 gcagatcggt caccttctgg ccgcgggcgg aggtgcccag gtcgccggtg ggcagtccgg
     1921 tcatccactg ctggaagcgc tcccacaacg gccggtccag gcccagcaga tggcggcggg
     1981 cggcgacgcc ggcggcgccc tcgccgcgct cggaggtggc cgacgcggcg tccccgggca
     2041 ggagttgtac cgcggcgaac accactgcca ggaggacggc cagcatcagc acccgtttgc
     2101 cgagcagcat cccgatccgc gcggcggccc gtccggcgcc ggtgccccga ggcgggccgg
     2161 gccgcgcggt gcggtcgtcg ggcggggcgc tcaccgcgcc agccacacgt gctccagctg
     2221 cacccgcccg tagccgggca gcttgggcag gttgcggacc ttgcgggccg ccaggtcgat
     2281 gccgtccgcc atgccccaca gcaggtagcc ggaccggtcg tgctcgatct gctggagtgc
     2341 gcgcagggca ctgcggcgcc gtgcggcgtc ggcggtgccc aggaccttgg cacaggcggc
     2401 gtcgaactgc gggtcggacc agccggcctc gttctgcccg gcgccggtgg tcatggtctt
     2461 cgaggcgaag aagaccaccg agtcgttggt gccccagtag ttggtgtaga ggtcgccctt
     2521 gagccaggtc ctggcgtaga aggtcccgga ctcctgcctg gtgaccttga tcttcagacc
     2581 ggcctcgcgg gcctgggcgg cgaagagcgt ggcggactcg gcgagcccgg cgatgtcctc
     2641 ggtggtgatc agctcgtagg tccgtgacag gtcgaagcgc gcctcgccca gcagtcgccg
     2701 ggcgcgcgcg aggtcgcggt ggcgctgcgg gacggccttg gcgtagtcgg ggtcgccggt
     2761 gccgaggatg tcgttggcga ccgtgccgta gccggagagc acctgcttga ccatggcctc
     2821 gcggtcgacg atcagcttga ccgcctcgcg gaccttcggg tcggcgaacg ggccgtcggc
     2881 ggcgcgcatc acgatcggca tcgccatgtc gttcgggcgg cggaggacct ggatgtcctg
     2941 gcggccggcg gcggtgcggg cggccaccgc accggcgttg gaggcgaggt cgatctgccc
     3001 ggcgagcatg gcgttggcca tggcctgcgg gctctcgaac atggtcacct cgatggcgtc
     3061 gaggtggatc tcgccgccgt gccagtggtc gttgcggacc aggcgggcgt tgccgccgcg
     3121 gtaccggtcg agcctgaacg ggccggtccc gggggcctgg gccagctcct tctcgggggt
     3181 gtccttcttc aggacgaagg tggtcaggcg ggtgagcagc gggagttcgg cgttggggcg
     3241 gtcggagacg aggacgacgg tgtccttgcc ctcggcggtg atgcggtggg cctggatgcc
     3301 ggggagccgg gcggcgccgg cgggggtgtt gcgcagtcga cgcagcgacc agacggcgtc
     3361 ctcggcggtg accggcgtcc cgtcgtggaa cgtcgcgcct tgggcgagcc tgaaccgcca
     3421 ggtccgcaga tcctcggacg cctgccagga agtcgccagc cggcccacgg tgttgtcctt
     3481 gcggccgggt gcggtgaggg tgtcgtggac cagcgcgatg atgaggtagt cgctctcgtt
     3541 gccctgggtt ccgtgggggt cgcgggtgat cgcggaggcc cggccgaggg cgcccacgcg
     3601 cagggtgccg cccttgcggg gcgggccgtc ggggccgtcg ccgtcggagt ccgcgcccgg
     3661 tccgccaccg cacccggaga ggagtgccgc ggcacccaac ccgccactca tacacagcag
     3721 ttgacgcctg ttcaggttca ccttcgcgcc ctcgttcccg cggtgtcgga ggagggggat
     3781 ccgcgaacgg acccaccgtg actaaggttt gcctacccta agggcgggta cccgtgcaag
     3841 ggctcgcacg gacctcggta cgaatcaaaa ctaaggtttg cctaacttaa tccatctgtg
     3901 tagtttcggc ggcacccgct caccgcgacc ggcctccgta gtggactcaa ctcccgtaca
     3961 cggaagccga gttgtggtgt gacgacacct ccaggaacgg atgacctcgc catgagcacg
     4021 ggttccgccc ccgttcgcct gctcgacgac gcatcgctca ccgaactccg ccgcgcggcc
     4081 gaggagatcc tcgccgccgc cggcacctcg gccacctcgc ccgagctgct cgccgccgtg
     4141 gcgcgctccg ccgccgccct cggcgccccg atccgccacg cctgccgccc cgtcgacacc
     4201 gacgacggcc tgttcgtgct ccgcgccctg gccgtcgacg acaccgggat aggccccaca
     4261 cccggcagtt gggccaccgc cggcgaccgc gccgccgtcc acgacatcgc gctcctgctg
     4321 ctcgccaccg tcatgggcaa ccccctcgcc tgggaaggcc agcaggacgg ccgcttcgtg
     4381 cacaacatcg tcccctcgtc cggccacgaa caggcccaga ccggcgccag cagcagcgtc
     4441 ctgctcagcc cgcacaccga ggacgccttc caccccggcc gcgcccacct gctgatgctc
     4501 gggtgcatgc gcaaccacga cgccatcgcc accaccgccg ccagcatccg caaggtccgg
     4561 ctcggcgacg aggacctggc cgtcctcgcc cgccccgagg tcccgatcct ccccgacgac
     4621 gcctacgccg aggcccgggg cttcgacggc cgccccccga acgtccccac gctgtgggag
     4681 tccgaggacg gccgcaccct ccgcttcgac cccgcctaca cccccctcga cgaggccacc
     4741 ccggagtacc gggccgccta ccgccgcctg tcggagcaac tcgccgccgt ctccaccgcg
     4801 gtcagcctcg cacccggtga ggtcctggtc gtcgacaacg acctcgtcgt ccacggccgg
     4861 gtgcccttcc gggcccgcta cgacggcacc gaccgctggc tcaaacgcgc ctccgtccgg
     4921 gtacccggcc gccgcacccg cccgcccgcc gaggccaccg agcacggcta cggacaggcg
     4981 gccatcgagg cgcacgccgc atgaaccacc agcagcctct cccggaggac ctcgtgaccg
     5041 accggagcac ccccgtccac gacatacccg gccgcaccct gcgcgccctg tccaccagtg
     5101 acctcgccgg catcgacatc accctcgccg acgtcgtcga gaccgtcgag caggcgtacc
     5161 gcaccctggc cgccggcgcg tccgacaacc cccgcaagct caccgtcaag cccgccgacg
     5221 ggcactccgt cggctatgcg atgctcggcc gcgacggctc ccgcgagatc gtcgccgtca
     5281 agacctcgta caagcacggc ctcgacaagg accgcggcga ccagcactac tacaccgcgc
     5341 tgacgctcta cgacgacatc agcgggctgc ccatcgcgat gatggactgc ggccggatcg
     5401 gcgccctgcg caccccggcc gtctccgcgc tgctggcccg cgcctgcgcc cggcccggcg
     5461 cgcgcaccgc cctcgtcatc ggcaccggca cccagggccg gctggccctg ccgttcctgc
     5521 tcaccaccct cccggacctg gaccggctgc tgctggcggg cagccacccc gacggcatcg
     5581 ccgcggtccg cgcggagctg caccgccact tcccggaccg cgacgtggaa ctcgtgaccg
     5641 atctgcgggc cgccgccccc tcggccgaca tcgtcgtcgc caccgccggt ggccacaccg
     5701 ccgccgcggt cgaggccgac tggctcgccc cgggcgcgct ggccgtcctc gtcgggcacg
     5761 gcctggcccc ctcgaccctg caccgcgccg accgggtcat cgccaccagc gaggcccaaa
     5821 tgcgggtcac cggcaccgac atggccgacg ccgaagggca cctccgcccg gtggacgccg
     5881 agttgccgcg gatcatcgcg ggcgccgcgg tcggtcgccg caccgccgac gagcggatct
     5941 tcggctacaa cagcggactg gtcgtcaccg acatcgccct cggccaccgc ttcgcccaac
     6001 tcgccctcgc ccagggccgg gggacgcagg taccgctgtg gcagtgaccg gcgaccgcac
     6061 ccccgccccc tccgcggtcc ccttcctccc ggccctcccg gaccccggca ccgacgccgt
     6121 cctggacagc gggctgctgc ccgagctctc ccacgccttc ggcgggccct tccacttcct
     6181 gctgcccgac cgcttcgacg ccaatgtcgc cgccttccgc acggccctcg ccgagaccgg
     6241 cgtggacggc cggatccact acgccaagaa ggccaacaag gccgccgtct ggatcgagcg
     6301 gtgtgccgcc accggcaccg gcgtggacgt cgccagcctc ggcgaactcc gcgaggccct
     6361 cggcaacggc gtccgcggcg agcgggtcgt ggtcaccggc cccgccaaga gcgaccaact
     6421 gctgcgggtc gcggtcctcc aggcatgcct gatcgccgtc gactccctcg acgaactgga
     6481 ccggttgctg caccacgccc cgccgggcgc cccgcgcgcg ccccgcatcc tgctgcggct
     6541 gctgccccca cagcagccgg gcagccgctt cggcatgacc ggcgccgagc tggacaccgc
     6601 cctcgcccgc tgcgtcgcgg ccggtgacgc ggtccggatg gagggcttca gcttccacct
     6661 ctccggctac gccataccgc cgcgcgtcga gctcgccgcc gccctcctcg accgctgcct
     6721 ggctgcccgc accatgggcc tccaggccga ccgcatcagc atcggcggcg gcttcgccgt
     6781 cgactactgc gcccccgccg actggtacgc cttcctcacc gcgcagcggc ccggccacta
     6841 ccacgcggac cggaccttcg acccggccga cttctacccg taccactcac cggtcgccgg
     6901 ggccgacgcc ctgcgcgccg tcctcgccgg caccaccgcc accggcacgg acagcggacc
     6961 gcggaccctg gccgatcggc tgcgggacac cggcaccctg ctgctgctgg agcccgggcg
     7021 ggcgctgctg gacggcgccg gtgcctccgt cttccggatc cagggcgtca aggaccgggc
     7081 cggctacgcc atcgtgaccg tggacggcac cagcctgagc ctgtccgagc agtggttcaa
     7141 cagcgagttc ctgccgcaac cggtcctggt cggcgcggac ggccgggcgt ccggcgacgc
     7201 cgcccacccc gcctgcgtcg gcggcgtcag ctgcctggag tcggacctgc tcacctggcg
     7261 caaggtcccc ttcccccggc gaccccaacc gggcgacctg ctggtctacc ccaacacggc
     7321 cggctaccag atggactcca acgaatcccc cttccacgaa ctgccgttgc cccccaaggt
     7381 cgtcctcgac cgcacggacg ggcgcccgcg ctggcggctg gaccgccgcc ccgccccctg
     7441 acccgaccgc cctcccgccc caggagcccg ccccatgaac gaggcactga gccgccccgc
     7501 cgtggtctcc cgcgtgtccg aactcgtcgg ctgcaccccg ctcctcgaac tgtgccgcac
     7561 cgagaacggc agccggctgc tgctcaaact ggagatgttc aaccccaccg gcagcgccaa
     7621 gatccggatg gcccggcaga tggtcctgga cgccgaggcc cgcggcgcgc tccgccccgg
     7681 cggccggatc gtcgagtcca cgtccggcaa caccggcctc ggcctcgccg tcatcgccgc
     7741 cgaacgcggc tacaccttca ccgccgtcgt cgaccgccac gccagcgccg acaagctccg
     7801 caccatgcgc gccctgggca ccgaactcgt ctacgtcgac gacgacggca gcgaggacct
     7861 ggccaccgcc gcccgcgagg agctggccga ggagctggcc cgcggccgcg acaacaccgt
     7921 cttcaccgaa cagcacaaca accccagcaa cggcgtcggt taccaccccg tcgcgcacga
     7981 gctgcaccag gcactggacg gccggctcga cctcctcata ggggccgtcg gcaccggcgg
     8041 cgcgctctgc ggcaccgccg gcgaactgcg caccctcata ccggacgtca ccaccatcgg
     8101 cgtggaaccc aagggctcca tcgccttcgg cggccccgcc cacgactact accagtccgg
     8161 caccggcacc cccgaaggcg cggagatcgg cgccctggtc gacttcgccc tcatcgacga
     8221 gggcgtcaag gtcggcgacg tcgaagcctt cgccaccgcc cgcgcggtgg cccgcaccgg
     8281 cctgctgatc ggcggctccg ccggcggcgt ggtccacgag gcgctgcgcc gactgccgtc
     8341 actgccgccc gggacgaccg tggtcgccct cgtcaacgac ggcggggaga agtacctgga
     8401 taccgtcttc gacgacgggt ggctggccgc ccgcggcctc ctcgcccccg acgtcgagcg
     8461 cgagatcgac gaacgcctca gcaaactccg caggaattga cggcccatgc ccttcatgcc
     8521 cgccccgcag cccaccaccc tcctccgcga cggccgcgcc ctggccgcgc tggccgtgcc
     8581 gctggtcctc acccagctcg cccaggtggc cctgaccacc accgacaccg tgatgatggg
     8641 cttcctgggc gcccgggacc tcgcggccgg cggcctcgcc atcgtcctct tcaaccagct
     8701 gcgcaccatg ggcgtcggcc tggtcacctc cgtcggcaac cggatcgccg ctgccgcggc
     8761 ccgggaggag gagggcgacg ccccgggaac cgacgccgac gtggccgccg tccggggcat
     8821 cgcccgggcc gggatggccg tcgccaccct cgccggactg gccggcgcgg tcctgatggt
     8881 cctcatcggc caggcgctca cctggttcgg ccaggacgcc gagatcgccg accgggcgcg
     8941 gccgatgctc gtggcgctcg cccccgggct gctgccctgc ctgtggttcc aggcgatccg
     9001 tcagttcacc gtcggcctgc gccgcccgca ggccctgctg cggatcaccg tcgcctcggt
     9061 cgcggtcaac gccggcctca actgggtcct ggtacagggc acctggggac tgcccaggct
     9121 cggcctgccc ggcatcggcg tcgccacctc cgccgtccac ctgctgtcct tcctcgccct
     9181 gtacgccgcc gcccggcggg acccggtcct ggccccgcgg ctcagcctca acgccgccgg
     9241 ggccgccgcc gccaccgtgc gcaccctcgt cggcctcggc gtgccgatcg ccgccaccta
     9301 cggctccgag gccggcttct tctccgtcac cgcgctgatg gccggcagct tcggcagcgc
     9361 cgcgctcgcc gcccacaccg ccgtcaacca actcgtctac atcgtcttcc aggtcgccgt
     9421 cggcctctcc cacgccgcgt ccatcaacgt cagccgggaa ctggccctgg gccgcaccga
     9481 ctccgcccgg cgcctgaaga acaccgcact ggcctgcgcc gccgtggtca tggcggtggt
     9541 cgcggtggtc tacctcgcgc tgccggagct ggtcctgcgc ccgttcttcg acccgggcgc
     9601 ggccggcgac cgggaggccc tcgcgatcgc cggccaactc ctgttcgtca tcgccgtgct
     9661 gcagttcttc gactgcgccc agaacatcgg cgtcggcctg ctgcgcggcc tggacgacac
     9721 caggagcggc ttccggatca ccctcgtcgg ctactggctg gtcggcctgc ccgccgcctg
     9781 ggcgctcggc tacgccgccg ggctgcacac cctgggcatc tggctcgggc tgctcgccgg
     9841 actcggcacc acggcgctgc tgctgctgcg ccggtacggc accgccctgc gggcgcggga
     9901 caccgctgcc cccgcggagg ccgcctgagc cgtggtgggc ggccgtgccg cacggccgcc
     9961 gctactgccg gtcgcgggag agcgacggca accccagccg gttcccggtg tcgtcgtcga
    10021 attccgcgca gaacccgccg atcgcgtcct caagatgggc gaaagaccgc gccgcgaaca
    10081 aaacagactg atagcaggaa atacggtact gagtgcttgc tgcggcacag aggtccagtt
    10141 cgcgcacttc ccggacctcg tgcgcggcga tctccccgta cgaggacagc agcgccgcgc
    10201 cgaaggcttt cggcccgccg gattcggtga tcagcccgta ttcgagggtg taccaataca
    10261 cgcggctcag aatgtccagc gcctccgcgg tccggacccg gttcgcggcc cggccgatga
    10321 cccggtacag ctcggcgatc gccggcgacg acagatggat cccgtgcccg aacacgtcgt
    10381 gcaggacgtc cggttcgggg gtgtacagcg gcacggccgg atggcgtacg aactgcaccg
    10441 catggaagta gccgtcctcc atcgccccca ggaaccgctc gttgggcacc actccgccgg
    10501 ccagcgtgag cgagaatccg gtgcgggtcc gcagcccggg cgtgatctcc gcgtgctgcg
    10561 ggatctgctc ggcaggtatg tccgcggcct cgccggccgc cagcacctcc cggcaggcgt
    10621 gcgcccggtg tgccggggcc agcgcgtcgt gcaccgtccg ccaggtccgg tgctcgtcct
    10681 cggtgtacgc gacgtcctcg tacggcgctc ccacccggtg gttctcggcg cgggccgcca
    10741 gggcgtcgcg ccgccgccgg tagtcctggt cgtggcgccc ggggtgctcg ttcgcgcgac
    10801 cgagccgtcc ctcgacggag acgggggtct gctttcgtac ggtgctcatg gccctgaacc
    10861 tgccccgcga cggggcgaag atcacctggc gtagcggtcg aagtacccgg cgccgcggac
    10921 cgttccggag gccccgccgg ccgctaccgc tctgccttcg gcctctcaac gcaggagccg
    10981 ccccgatgtc gttattggtt cgtttcttga ctatccgggc ttcagtgacg ttcactcagc
    11041 cattcatggg ccgagtcagg gcggcccctg tggaggtacc tttcatgagg ccgatgaagg
    11101 ctatggacgc ggtgaatgtg atgaatgcaa caatatgtcg ccgtgtcgtc gtcagtgcgt
    11161 tgactctttc cctcgccgcc cccctggcgg cgtgcggaag tgatcatcag gaagcgcccg
    11221 aagggaagga ccacatcggc ctccttcttc cggagaacaa atccacgcgc tacgagaatt
    11281 ttgatcgccg tatcatttcc cggcgaatcg cgtcgctctg cctcgaatgc aaagtggact
    11341 acggaaacgc cgagtccagc gcggagaccc aacgcaccca gttcgagtcc ctggtgaaga
    11401 agggcgtcaa ggtcatcgtc ctcgacccgg tcgacgcccg ggccgccaag gactgggtgg
    11461 actccgccgc acgtcagggc gtccaggtcg tcgcctacga ccggctcgcc gagggcaacg
    11521 tcacggcgta cgtctcctac gacaacgaca agatcggccg cctccagggc gagggaattc
    11581 tcaccgcgct cggctcccgg gcggccaccg ccgacgtcgt catgttcaac ggctccccgg
    11641 gcgacccgaa tgccccgtcc ttcaagaagg gcgcgcacgc cgtcctcgac ggcaaggtcc
    11701 acaaggtcgt ctacgagaag gacgttcccg aatggtccga ggcgaccgcc aagaaggaca
    11761 tgaccgacgt catcaactcc cgcggtccgc atggcttcga cgcggtctac tcggcaaatg
    11821 acggcatggc cggcggtatc gccgcggcgc tgaaggccgg cggcgtgaaa aacgtcccgg
    11881 tcggtggcca ggacgccgaa ctccccgcac tgcagaggct gttggacgga actcaggcgt
    11941 tcactgttta caaggaggtg cgcccggagg ccgagaccgc cgcggagatc gccttccgcc
    12001 tgctgcgcgg gcagagcatc gcctccctca cctcgaccac cgccgccaac acgagcaagt
    12061 ccggcatccc cgccaagctc ttcaacgcca cgctggtcac caaggcgaac ctcaaggaca
    12121 ccgtcgtcca gaacggcgcg gtccgcgccg acctgctctg caccccggcc gtcgcggcgg
    12181 agtgctcctc cctcggcatc cagtgaggca ccccggggcc ggcgcgcgga cgcggccggc
    12241 cccgggcaca ccacgcttcc cccgcgccgt ccggccgccc gcgccacgca ggcgccgccc
    12301 gcgcgccgaa ctcccgccgg ccgcccggcc cgccgccctc agtccggctg cgccgccgcc
    12361 ccgcccacgg cctcgaccag cggcagcatc cgatgcggta cccgctcgcg cagcaccacc
    12421 tcggtgcggg tgcggaccac ccccggcagg ctgatcagcc gctggatcac gtcctccaga
    12481 tgtgccgcgt cccgggccac cacgcgcgtc agcagatccc cgccgccggt ggtcgagaac
    12541 gcctcgatga tctgcggcac ctcgcccagc gcggcggcga cctcctccag atgcccctgt
    12601 gtcacctcga tgtgcacgaa ggccagcatc ggatggtcca gcgcggcggg cgagagccgc
    12661 ggcccgtagg cggtgatcac cccgtcccgc tccaggcggt ccagtcgcgc ctgcaccgtc
    12721 ccgcgggcga cccccagcac ccgggcgtac tcccgcacgc tcgtccgcgg ctgctccagc
    12781 agcaacctga ggatcttcgc gtccagcgcg tccacggcca tcggcccacg gcctcctcac
    12841 ggtcggcgga tcggtcggca cggtgccgag aggggcggag cgtttccggg gatagatcca
    12901 ttatccaggc gcggagcccc tcccgtcacc gtatccgagg aggatctttt gcgccgattc
    12961 gccccctagc gtggaggcac ccgacccgac gcagggtcac cctcgacgtc tggagcacga
    13021 tggcgcacga cacaccccgg caccgcaccg acgacctggc cgcggcggcg gccgaactgg
    13081 tcgccatggc cgccgaggac aaccgggccg caccccgcgc caacagcggc gacttcgccg
    13141 accagttggc ctggcgccgg ctgaccgcgc ggcacgccga ccggctcacc gagatcatcg
    13201 acgcccacgg ctggcccacc gcggaccgct tcggggcgga cgccgcccgc ggcgcctggc
    13261 tggtagccca gcacgccgac cgtcaactgg acgtgcagcg gcgcgccctg cacctgatgg
    13321 aacgcgccgt cgccgacggc ctggcgagcc cccgcgacct ggccttcctc acggaccgca
    13381 cgctggtcaa cgacgggcgg gagcagatct acggcaccca gatcgccggg gtccgggacg
    13441 gcgcgcccgt gccgtggccg tgccgggatc cggagcggat ggaccagcgg cgggtcgagg
//
