LOCUS       NZ_CP054019            20612 bp    DNA     linear   CON 28-JAN-2024
DEFINITION  Streptomyces sp. A1-5 chromosome.
ACCESSION   NZ_CP054019
VERSION     NZ_CP054019.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. A1-5
  ORGANISM  Streptomyces sp. A1-5
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9459690)
  AUTHORS   Dashti,Y., Sumang,F.A.M., de los Santos,E.L.C., Alcantara,E.P. and
            Challis,G.L.
  TITLE     Structural revision and biosynthesis of polyketides FXJ15321 and
            FXJ15322 from Streptomyces sp. A1-5
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9459690)
  AUTHORS   de los Santos,E.L.C.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAY-2020) Warwick Integrative Synthetic Biology
            Centre, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL,
            United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: JUN-2019
            Assembly Method                   :: Flye v. 2.4.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology :: Oxford Nanopore MiniION; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/28/2024 04:28:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,328
            CDSs (total)                      :: 8,230
            Genes (coding)                    :: 7,847
            CDSs (with protein)               :: 7,847
            Genes (RNA)                       :: 98
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 74
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 383
            CDSs (without protein)            :: 383
            Pseudo Genes (ambiguous residues) :: 0 of 383
            Pseudo Genes (frameshifted)       :: 156 of 383
            Pseudo Genes (incomplete)         :: 280 of 383
            Pseudo Genes (internal stop)      :: 26 of 383
            Pseudo Genes (multiple problems)  :: 73 of 383
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:08:01
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7430967
            Orig. end                         :: 7451579
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP054019.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Philippine National
            Collection of Microorganisms.
FEATURES             Location/Qualifiers
     region          1..20612
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="linaridin"
                     /region_number="26"
                     /rules="(cypemycin or cypI)"
                     /tool="antismash"
     cand_cluster    1..20612
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cypemycin or cypI)"
                     /kind="single"
                     /product="linaridin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20612
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10612](-)"
                     /cutoff="20000"
                     /detection_rule="(cypemycin or cypI)"
                     /neighbourhood="10000"
                     /product="linaridin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10612)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cypemycin or cypI)"
                     /neighbourhood="10000"
                     /product="linaridin"
                     /protocluster_number="1"
     misc_feature    89..103
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.54"
                     /tool="antismash"
     gene            complement(203..>909)
                     /locus_tag="HRD51_RS32635"
                     /old_locus_tag="HRD51_32215"
                     /pseudo=""
     CDS             complement(203..>909)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612357.1"
                     /locus_tag="HRD51_RS32635"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="HRD51_32215"
                     /product="IS5 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="VDSTTPHAHHHAAGMRLDAELMAEPEKAAEEEKGVRERHERLTTS
                     PVTPPKKRAAPNADGSEGATGPG"
     gene            complement(846..1052)
                     /locus_tag="HRD51_RS32640"
                     /old_locus_tag="HRD51_32225"
     CDS             complement(846..1052)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HRD51_RS32640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HRD51_32225"
                     /product="hypothetical protein"
                     /protein_id="WP_205369106.1"
                     /transl_table=11
                     /translation="MAPVVLPAPRPAADAPAPEIEEVEDDQELILEDLTHDQVLDWRAR
                     AAAWTPPRRMPTTMPPGCGWMPS"
     gene            1617..1871
                     /locus_tag="HRD51_RS32645"
                     /old_locus_tag="HRD51_32230"
     CDS             1617..1871
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HRD51_RS32645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HRD51_32230"
                     /product="hypothetical protein"
                     /protein_id="WP_235094859.1"
                     /transl_table=11
                     /translation="MSYSKRIAAAVLVAGAVLGVGALPASAADRGYDHGHHRGYHGRHL
                     GYHHDRDGWRHGGEGFRGEGWRHDHEGFRGWRHGRHNWR"
     gene            complement(2098..2763)
                     /locus_tag="HRD51_RS32650"
                     /old_locus_tag="HRD51_32235"
     CDS             complement(2098..2763)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016657 - obsolete oxidoreductase
                     activity, acting on NAD(P)H, nitrogenous group as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014151868.1"
                     /locus_tag="HRD51_RS32650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_32235"
                     /product="nitroreductase"
                     /protein_id="WP_235094860.1"
                     /sec_met_domain="PF00881 (E-value: 3.2e-27, bitscore: 94.5,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVYEAVASRRAVRRFSEEPIPRETLERVLSAAARTPSGANLQPW
                     HIYVLTGAPLAELKKRTAERVAAGDPGDEREYQMYPSELKSPYRERRSAAAEQRYTALG
                     ISREDRRSREAAVAANWDCFGAPAALFCYIDRDMGPAQWADLGMYLQTVMLLLRAEGLH
                     SCPQMAWSVYCRTVAGAVLPPPGLILFCGVSIGFEAPAACHDRIDRAPLAETVTFIDG"
     gene            2858..3760
                     /locus_tag="HRD51_RS32655"
                     /old_locus_tag="HRD51_32240"
     CDS             2858..3760
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015655847.1"
                     /locus_tag="HRD51_RS32655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_32240"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_205369103.1"
                     /transl_table=11
                     /translation="MSAHDGLAEGFETHRSRLRAVAQRMLGSHSEAEDAVQEAWLRLAR
                     TQADAVHNLGGWLTTTVSRICLDMLRARASRREDPAGHPVPDEDPDPAASGHPEQEAVL
                     ADSVGRALLVVLDRLGPAERVAFVLHDMFAVPFDEIAPVVDRSLSAAKQLASRARRKVR
                     GAPAVPGAELARQRLIIEAFLAAARAGDIDAVLAVLAPDAVRRADRAALPEGRPLEVRG
                     ARAVAEEIVVFGRNAHVAEPVLIGGAVGITVAPYGRLQLALTVTTACERITGYELIADP
                     NRLQQLDLTLLDEAIPLGG"
     gene            4000..4353
                     /locus_tag="HRD51_RS32660"
                     /old_locus_tag="HRD51_32245"
     CDS             4000..4353
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019151.4"
                     /locus_tag="HRD51_RS32660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_32245"
                     /product="HNH endonuclease family protein"
                     /protein_id="WP_268826907.1"
                     /transl_table=11
                     /translation="MKNLGAAWTDNTSAPGGHNHCDTRDDILKRDLKDVKFEGTSKCLV
                     ASGTLADPYTGKNIAFQRGPKSSAVQIDHLVALSDAWQTGAQQLLQDHNDPLNLVAADG
                     PANMGKGDKDAAS"
     misc_feature    4009..4011
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(4835..5647)
                     /locus_tag="HRD51_RS32665"
                     /old_locus_tag="HRD51_32250"
     CDS             complement(4835..5647)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015696.4"
                     /locus_tag="HRD51_RS32665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_32250"
                     /product="ALF repeat-containing protein"
                     /protein_id="WP_235094862.1"
                     /transl_table=11
                     /translation="MKLSRISTVVAAAAIAPAVLFASPAVAADTATPPASSTPDTAPDA
                     KPDTQGNAKADKNNRFAILKILSDQNSGPGVRKAAEAALNSTPEDRVHFLGVGRQQAQD
                     VDDRVRTSQILHNGGPKVKEAANKALDGTMEDIRYFLEVGQYEARAKDKADAKRFAEQA
                     AKDVAEEAAKDAAKNKHAPGTEGKHGEADKPATSEQHTHNAGDRGADAKPAVAPGQDTA
                     KPSQNTGAQLAASGAGPATPWAIGGTAIALTTGAGLVLASRRRTSTEN"
     misc_feature    complement(5635..5647)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.11"
                     /tool="antismash"
     misc_feature    5676..5692
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.51"
                     /tool="antismash"
     gene            complement(5766..7220)
                     /locus_tag="HRD51_RS32670"
                     /old_locus_tag="HRD51_32255"
     CDS             complement(5766..7220)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014135440.1"
                     /locus_tag="HRD51_RS32670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_32255"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_235094863.1"
                     /transl_table=11
                     /translation="MTPDAVIVGTGPNGLAAGVTLARAGLKVELYEAHGTIGGGLRTKP
                     LFDSDIHHDICAAVHPMAAASPFFTEFDLTTRNVDLLRAEAGYAHPLPGGRSAVAYHDV
                     ERTCAELGPDGARWRSLMRPLLGHSGELVDLILSGPRALPGAAATALRLAPRLLAHGTP
                     LATRQFTGEPARALLAGVAAHAVGRLPTLAGATVALLLGHLAHTTGWPLPRGGSARIAD
                     ALAADITAQGGVFHTGRHIVDLRELPPARAVLLDVAPKGLLQIAGDRLPARYRARLARF
                     RYGPAAAKVDFLVSGPVPWAAPETARAPTVHLGGTQAGIFRQETLTTRGIATGEPFVLL
                     VDPAVADPGRAHHGKRPVWAYAHMPHGSTTDPYDLIRGQIERYAPGFTDTILAHRSITG
                     AAYEAYNPNYVGGDIGAGAMTLKQSLARPVPQTDPYRTPLRGLYLCSAATPPGPGVHGM
                     CGYLAARSALRREFGIHEAPALAHRL"
     gene            complement(7217..8917)
                     /locus_tag="HRD51_RS32675"
                     /old_locus_tag="HRD51_32260"
     CDS             complement(7217..8917)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006132584.1"
                     /locus_tag="HRD51_RS32675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_32260"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_235094864.1"
                     /transl_table=11
                     /translation="MNVWEIARGHTALLLTGTVLGVAGAAATLAQPLVIGEMIKSVAAD
                     LPLTGPVLLAIALFATDAALATAHAYAIGRAGENVVYDIRHTLAARLLRSRLQSYRRWD
                     QGDVFTRMVTDTSLARVCLTQALAQIVTSAFMVLGGIAMMGRLDPLLLVTTLSCLGLAS
                     VVSLLLARQVRRVSVTNREDTSAFGSALLRVLGALPTVKASRAEGRESDHVSALARQAR
                     RSGIRVSALSAMLTPAMNVGTQLALTVVIAWGMARVATGDMAPADLTAFMMYLFYLVSP
                     LVMLFMSVAQFQQGRASIDRIAELGTLDQEDTGPGSDITLDEHGISFEKVSFTYPGSDT
                     TVLDNVSFTVPERGLTAVVGPSGAGKSTVFQLIERLYAPTSGTIRMGGIDIASLPLGQL
                     RSLVGYVDQDHTLLRGTVRENLTYAAPDATAREIADALDKAHLTDVIAALPDGLDTELG
                     ERGAGLSGGQRQRLAIARALLQRPRIVLLDEATASLDGESEAALRDSIDIIARHCAVVA
                     IAHRFSTITQAEKIIVLAGGGVQASGTHAELHAGNGLYRRLAEAQEAPA"
     gene            complement(8914..9705)
                     /locus_tag="HRD51_RS32680"
                     /old_locus_tag="HRD51_32265"
     CDS             complement(8914..9705)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013005800.1"
                     /locus_tag="HRD51_RS32680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_32265"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_235094865.1"
                     /transl_table=11
                     /translation="MNAIATPGPAGAVDDIGYGRQFDGWYDRLFPKDESATVTAERLAG
                     LHPEPAAGTVEFGVGTGRIAVPLARRVGRITGIDSSPEMLAALRAALDDDTPVEPVHGD
                     IRTHTAEHTAGLVYCVCGTLSMLLDPDDQQRAIHRAADLLAPGGRLVVETHNKAAILAL
                     HEGRTRTTYFTPYPEPGTGLQTHSVLLTEGSLWHCSHIWYESDGRTRVGTELSRLTTPE
                     EVDGYARAAGLRPESRSADWHGTPYTEQSPMFVTTYVKAAV"
     gene            complement(9702..9863)
                     /locus_tag="HRD51_RS32685"
     CDS             complement(9702..9863)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HRD51_RS32685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_235094866.1"
                     /transl_table=11
                     /translation="MNKSAVAGCLAVGLAVLGFLTATGTVNIPIAMGAGVALFIAAGVE
                     IKRKKPTR"
     gene            9862..9990
                     /locus_tag="HRD51_RS41935"
     CDS             9862..9990
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HRD51_RS41935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_268826603.1"
                     /transl_table=11
                     /translation="MTFSLLPSRTVCPGGQYGFADYFLRRPRAMTAAITTPTAMMM"
     gene            complement(10001..10612)
                     /locus_tag="HRD51_RS32690"
                     /old_locus_tag="HRD51_32270"
     CDS             complement(10001..10612)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     linaridin: cypI"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013005804.1"
                     /locus_tag="HRD51_RS32690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_32270"
                     /product="hypothetical protein"
                     /protein_id="WP_205369098.1"
                     /sec_met_domain="cypI (E-value: 1e-31, bitscore: 108.9,
                     seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPRTAAADLFTGKGAGWRIAGAAMLVSTLAVQHPNPMFNRLQL
                     KDTFSMLPNWRFFAPTPATHDYHFVYRTLGTEGTTSRWQGLDVIEGRKPWQIAWFPTRR
                     PEKAVFDICSEILHVIDKGFAVVTRTAGYRTLTEHLRATLLDRGTSAREIKGFQFALAR
                     ATGYDTTHTPEMVFVSPYIPFDPGAAVSPPAVRAGTTVEA"
     gene            complement(10609..12498)
                     /locus_tag="HRD51_RS32695"
                     /old_locus_tag="HRD51_32275"
     CDS             complement(10609..12498)
                     /NRPS_PKS="Domain: Abhydrolase_1 (347-456). E-value:
                     4.9e-10. Score: 31.4. Matches aSDomain:
                     nrpspksdomains_HRD51_RS32695_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005474563.1"
                     /locus_tag="HRD51_RS32695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_32275"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_235094867.1"
                     /sec_met_domain="PF00561 (E-value: 3.4e-07, bitscore: 29.1,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Thioesterase (E-value: 2.3e-07, bitscore:
                     30.2, seeds: 16, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.7e-15, bitscore:
                     56.5, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFVKKIAAAVFAPAPVSRDRALGLSERLTAVTTLTSSLEYLSQR
                     KEIRQGGLNDWNIVKDVQAQSTPVVRRLLNAVSGPRTTTALHLTRATVAAGMLLPGNSR
                     WRGAGNIFLGASSALLYPRHRYGTDGSDQVAILVQTATGAARLTRSAPAKDALLWYVAL
                     QANLSYLISGWVKLIGEPWRDASALGGVMRTRTYGHPGMFRWTQDHPKAAKYLTHGVLA
                     LECLFPLAYACGGRLARPLIASAAAFHLANGYFMGLGRFVTAFTAMHPMVAYTSTPRSH
                     PAAAGRDDRALPAALALLAAATAAAMGTAVQRRLRATEGWHTSRVLTTRHGNELQYEVL
                     SPGDGTQPVFVFAAGMVSTSEHFAWITERLAQDTEHGVLTYARAGYAGSRYRSPGRFTL
                     GQSVDDLVDLVNGAVAPHRKVILVGHSLGGEIARRAAQQLGDRLHGVVYLDASHPDELN
                     RSQQQRDTAGKLRTALTQMTWYLRLGTGILMARPDWLESLPVAYRKKVFAQYADVRMWD
                     AGRREWNAVEADFRAFSGALPPIHGAHGLVVSAQQTVDRDPDQLLMHKELADAHRDGRT
                     ETVVIEGAGHDTVLTMGRYAHQVADCITEFFGITTTGAPGTAAEPTTGMEPGK"
     aSDomain        complement(11131..11457)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HRD51_RS32695_Abhydrolase_1.1"
                     /evalue="4.90E-10"
                     /label="HRD51_RS32695_Abhydrolase_1.1"
                     /locus_tag="HRD51_RS32695"
                     /protein_end="456"
                     /protein_start="347"
                     /score="31.4"
                     /tool="antismash"
                     /translation="PVFVFAAGMVSTSEHFAWITERLAQDTEHGVLTYARAGYAGSRYR
                     SPGRFTLGQSVDDLVDLVNGAVAPHRKVILVGHSLGGEIARRAAQQLGDRLHGVVYLDA
                     SHPDE"
     CDS_motif       complement(11182..11253)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HRD51_RS32695_0001"
                     /evalue="9.40E-06"
                     /label="NRPS-te1"
                     /locus_tag="HRD51_RS32695"
                     /protein_end="439"
                     /protein_start="415"
                     /score="18.2"
                     /tool="antismash"
                     /translation="PHRKVILVGHSLGGEIARRAAQQL"
     gene            complement(12638..12799)
                     /locus_tag="HRD51_RS32700"
                     /old_locus_tag="HRD51_32280"
     CDS             complement(12638..12799)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HRD51_RS32700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HRD51_32280"
                     /product="hypothetical protein"
                     /protein_id="WP_180990269.1"
                     /transl_table=11
                     /translation="MIDVAAAANEMEIPEEGAIFPMATPVLATPAAFMGGIAISSAVVG
                     AFEAGRNG"
     gene            complement(12915..13115)
                     /locus_tag="HRD51_RS32705"
                     /old_locus_tag="HRD51_32285"
     CDS             complement(12915..13115)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006132579.1"
                     /locus_tag="HRD51_RS32705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_32285"
                     /product="hypothetical protein"
                     /protein_id="WP_205369096.1"
                     /transl_table=11
                     /translation="MTEIVSFVNGLDLGAIETGEAHSDQTPVLATPAAALAAIGGAKAV
                     GAFVGGATVVGGAYALGRAVG"
     misc_feature    complement(13121..13136)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.37"
                     /tool="antismash"
     gene            13355..14308
                     /locus_tag="HRD51_RS32710"
                     /old_locus_tag="HRD51_32290"
     CDS             13355..14308
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003980564.1"
                     /locus_tag="HRD51_RS32710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_32290"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_235094868.1"
                     /transl_table=11
                     /translation="MEVNEQQNVIDAIGLWRRYGGDGERGFDAVRGIDLTVAQGELFAL
                     LGTNGAGKTSTVELLEGLAPATKGTIRLFGNLDPVRDRARVRPRTGVMLQQGGFPSDLT
                     VAETIRMWASCTTAPRPDAEAAAMVGLTGRRDVAVKNLSGGERRRLDLALATLGRPELL
                     FLDEPTTGMDPEGRHDTWRTIEELQAEGTTIVLTTHHLEEAERLADRLAIMHAGQIAVT
                     GTVAAIVAAHPSTLGFRLPPGLTPDDLPHSAVLQAEVTVATDRVELLTDQLQHTATEVL
                     NWARDRQLELEELHASSASLEEAFLRIARKETKEPV"
     misc_feature    complement(13364..13378)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.31"
                     /tool="antismash"
     gene            14305..15072
                     /locus_tag="HRD51_RS32715"
                     /old_locus_tag="HRD51_32295"
     CDS             14305..15072
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013245.4"
                     /locus_tag="HRD51_RS32715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_32295"
                     /product="ABC transporter permease"
                     /protein_id="WP_235094869.1"
                     /transl_table=11
                     /translation="MSNATTHLAALSRVELTLFLRSRSNLFNVLVIPAMITMGTTTVMK
                     QFDLEGAGLAMGQVMISTSAGIVLVMALYAPLVGTYVLRREEHVLKRLRTGEVSDLVIL
                     ASPAVPMTMAAVFQFALIATAVSAIAGLGAPAAPHLVLLGVLLGAVLTAAIAALSTAAA
                     RTAESAQGISTIGFLLLLLTSGTLVPLEVLPDAMGDVLRFFPLTPVTELVRSGWTGQHA
                     GPADTLIAIVTLLAWTALAAWGAHRNFRWEPRT"
     gene            15069..16280
                     /locus_tag="HRD51_RS32720"
                     /old_locus_tag="HRD51_32300"
     CDS             15069..16280
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF019350.4"
                     /locus_tag="HRD51_RS32720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_32300"
                     /product="histidine kinase"
                     /protein_id="WP_205369093.1"
                     /transl_table=11
                     /translation="MSTASGAAQARHQIDVKRATAHTRWMLCLIPWLLLASLLWPLLSH
                     LDHADADRLPPAIGWAIATLTALQGLGATTAVAYSIGRARHSATLIGAMAAVTLLELAL
                     LPWAHDVGLLDSTRSLIPASIMVALPLSFALSSAMGRRAYTAVAVGESVLAGGAVLVAD
                     RAAAPAVLAFTAATWVVIGSLMRSSMWFLTVLWQLNAAREAQTRLVIAEERLRFARDLH
                     DVIGSDLSVIALKAELAERLAQAPEARSEMAHVQSLTRGLHHEIREVVNGYRTTDLTTE
                     LQGAQAVLEAAGVSCRIHREGDVPLPQEAQTALGWAVREGVTNVLRHAQASTCTIRLTG
                     TGHGPTRLDIINDGTGQQTASERGNGLAGLVERLAPLGGTVSHGREAGPTYRLTVHLPR
                     QDNR"
     gene            16277..16882
                     /locus_tag="HRD51_RS32725"
                     /old_locus_tag="HRD51_32305"
     CDS             16277..16882
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003968028.1"
                     /locus_tag="HRD51_RS32725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_32305"
                     /product="response regulator transcription factor"
                     /protein_id="WP_205369092.1"
                     /transl_table=11
                     /translation="MIRILLADDEHLIRGAFAALLALEEDLDIVAEAATGPEAVTMALR
                     HKPDVAVLDLQMPGKDGVAVVEELTTSLPDCKTMIVTSHGLPGPLKRALTHGVKGFVLK
                     TVSAHQLATIIRTVNAGNRYIDPILAADAISAGASPLSAREADILSLATDGAPIEEVAE
                     RAALAPGTVRNYLSSATTKLGAENRHAAVHVAQQRGWI"
     misc_feature    17185..17203
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.34"
                     /tool="antismash"
     misc_feature    17476..17487
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            17476..18321
                     /locus_tag="HRD51_RS32730"
                     /old_locus_tag="HRD51_32310"
     CDS             17476..18321
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058979.1"
                     /locus_tag="HRD51_RS32730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_32310"
                     /product="IS5 family transposase"
                     /protein_id="WP_039631490.1"
                     /transl_table=11
                     /translation="MSERKPYPSDLSDEQWSLIEPVITAWKDRHRSVSGHQGAYDMREI
                     VNAILYQGRTGCQWAYLPHDLPQKSATYYYFAAWRDDGTDQVIHELLRCQVRERARRLE
                     DPTLVVLDTQSVHAAVGVPAATTGYDPAKRVPGRKRGVAVDVLGLVIAVAVLAANVHDN
                     TAGIALLDQVAEHTGDTVRKALVDQGFKNQVVEHGAGLGIDVEIVERDPGYRGFLPQPK
                     RWRVEQTYGILILHRRLVRDYEHRTASSASRVYWAMSHVMIRRLTGTNTSTWREEAVSA
                     "
     misc_feature    17506..17508
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    17782..17784
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            18318..18716
                     /locus_tag="HRD51_RS32735"
                     /old_locus_tag="HRD51_32315"
     CDS             18318..18716
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006131781.1"
                     /locus_tag="HRD51_RS32735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_32315"
                     /product="hypothetical protein"
                     /protein_id="WP_039631487.1"
                     /transl_table=11
                     /translation="MNVRPLLEALDLQEEAARALADDLRAQIDDLQTRLREAETHLEHL
                     AITRKTVTSLADQLPAPPPELPEHPDYPRILAAFNESTGPLRAKDVCQALGHELLPKNV
                     EGTRAKLKRLVKLGILTEADTGCFTRRQ"
     gene            complement(18892..19698)
                     /locus_tag="HRD51_RS32740"
                     /old_locus_tag="HRD51_32320"
     CDS             complement(18892..19698)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HRD51_RS32740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HRD51_32320"
                     /product="2OG-Fe(II) oxygenase"
                     /protein_id="WP_205369091.1"
                     /transl_table=11
                     /translation="MTHVATELAPWVNLEKYPVSELDGSAGRALVDEARASFNDTSLVV
                     LDDFLRPEAVRQVATRSLKDAESLGFRFTGSNDVFLGTGEPAAPVHGQVGREHTKTTLA
                     YDRIDESSPLKALYRSEPVLAFVRRVVGEPVYRSADPLGAMTVHVHHDRDEQDWHFDVS
                     QYTIVLHILAPESGGVLEYVPRSRARAEQDQAELRAIAGGERHPLIHELPTVPGTLVLH
                     SGRNSMHRVTPVEGTTPRISATMSYNSAPGGQLNEYTRSLYFGRPQ"
ORIGIN
        1 atcggaatgg cactgtggtg atgctgtgtc atgtttcgcg tggagagatc ctgtgcgcca
       61 cactgttcga cgcacaggaa cttcactcaa tcttcacgaa gttcggcacg ggcgcagcgg
      121 aatccggatg cctgcgcggg atccgtcggt gaagcacgca tgacgcccga tgacacctag
      181 ggcgtcttcg tagttcggat ctttaggttg gttggaggct gcggatccac aggatcgccc
      241 cgcgcagagg gagtccggcg aggtagctct cgggcgtctt gtcgtagcgg gtggccggcc
      301 cgcgccactc cttgatcttg ttgatgcagc gttccaccgt gttgcgctcc cggtacagca
      361 tggtgtcgtg ggtgaccggg cggccgccgc gagagccctt cttcttgcgg ttggcagcct
      421 ggtccgcctc ctccgggatg gccgccttga ccttccggtt gcgcaggtag gcgcggttgg
      481 cgcgggacga gtacgcctta tacgcagcga cggcgtccgg acgggtacgc ggccgcccga
      541 cggggacgcg gactttgctg cgctccacca cggcgcgaaa gcgcgggctg tcggcggcct
      601 ggccgggggt gagcgcgaat gacagcgggc ggcagcgccg gtcggccgcg aggtggacct
      661 tgctggtcag cccaccgcgg gaacggccga gtgcggcagt ggtcagccgg gcccggtagc
      721 gccctcgctg ccgtctgcgt tcggcgcggc ccgcttcttc ggcggcgtca ccgggctcgt
      781 ggtgaggcgt tcgtgccgtt cacgcacccc cttttcctcc tcggcggcct tctccggctc
      841 cgccatcagc tcggcatcca gccgcatccc ggcggcatgg tggtgggcat gcggcgtggt
      901 ggagtccacg cggcggcgcg ggcgcgccag tccaggacct ggtcgtgggt caggtcctca
      961 aggatcagct cctggtcgtc ttcgacttcc tcgatctccg gggccggggc gtcggcggcc
     1021 gggcggggcg cgggcaacac aaccggagcc accggcggaa cggccgagac gctaccctcg
     1081 gaccgcgcgg ccgcagcttc agcacggcct gcaacgacca cctacccggc gcggacccgt
     1141 gcccgctccc gcccacgccc tgcccgaaac ctcccggtgc aacggccgct gcgcctcacg
     1201 ggcccagggc atggcggccg aggccctctt ccttgtgcgg ggcctggtcg gccacccact
     1261 tgtcgaccac caccttcctc caatgacgcg gacgcgcggt caagactgct gccgcagatc
     1321 atcgaatccc gcgaacgacg acacacccgc gtactccatg tctgccctgt tcttcgcccg
     1381 cgatggccgg gaacagcgcc agggtgggcc gtcgcaaccc ctgtcgacga tgccgcgctg
     1441 acgtcagaca gcatcgggga agaaatggga cattgttcgg gattggtaac ttacagcgcg
     1501 cccaaggggc ttgggcaggc ttgatcggaa ggattccctt tgccggtgac cagccggcag
     1561 atccgtgtcg tgatcggcgg ggctctcgcc gtattgcgcg aggaagggaa ttgttcatgt
     1621 cctacagcaa gcgcatcgcc gccgccgtgc tcgtggctgg cgcggtcctc ggagtcggcg
     1681 cacttcccgc ctccgccgcg gaccgtggct acgaccacgg ccatcaccgc ggctaccacg
     1741 gccgtcacct cggctaccac cacgaccgtg acggttggcg gcacggcggt gagggtttcc
     1801 ggggcgaggg atggcggcac gaccacgaag gcttccgcgg atggcggcac ggccgccaca
     1861 actggaggta ggccgaaaag gcgtcgggag ctgcgcagtg agccgatgcg ggccaggtga
     1921 tgaggatccg cggatgtgag cgggtgccgt caaaggcttg attcggattc ggctgggccg
     1981 ccggccctgg gcaccgcgaa ccgggcgtgg ggcaggcccg ccggttcact gttcagggcc
     2041 ggcggggcgg gaagagcggc gatcccgccc cgctaccgga ctgacggcag gaacgcccta
     2101 gccgtcgatg aaagtgaccg tctcggcgag cggggcccgg tcgatgcggt cgtgacacgc
     2161 ggccggggcc tcgaacccga tggacacgcc gcagaacagg atcagtcccg gtgggggcag
     2221 cacggccccc gcgacggtcc ggcagtacac cgaccacgcc atctgagggc agctgtgcag
     2281 cccctcggca cgcagcagca gcatgacggt ctgcaggtac atgccgaggt cagcccattg
     2341 ggccggtccc atgtcgcggt cgatgtagca gaacaaggcc gcgggcgcac cgaagcagtc
     2401 ccagttcgcg gcaacggccg cctcgcgcga ccgccggtcc tcgcgtgaga ttccgagcgc
     2461 ggtgtagcgc tgctcggcgg ctgcggatcg gcgctcgcgg tacggagact tcagttcgga
     2521 cgggtacatc tggtactccc gctcgtctcc ggggtcgcct gcggccaccc gctcggcggt
     2581 gcgtttcttc agctccgcca gcggcgcgcc agtgagcacg tagatgtgcc agggttggag
     2641 gttcgccccg gacggtgttc gggctgcggc ggacaggaca cgttccaacg tttcccgggg
     2701 gatcggctcc tcgctgaacc ggcgcaccgc ccgtcggctc gcaaccgctt cgtagacgtc
     2761 caagacaagc tccctgcata tcgactctgg ccccgccagc cacctggtgt cggggccctc
     2821 tacggtggtg acggtcggcg acggggagag gtgacaggtg agcgcgcacg acggcctcgc
     2881 agagggcttc gagacgcacc gcagccgact gcgcgcggtc gcccagcgca tgctcggctc
     2941 gcacagcgag gcggaggacg ccgtccagga agcctggctg cgactggccc ggacccaagc
     3001 cgacgccgtg cacaacctgg gcggatggct cacgacgacg gtctcccgca tctgcctcga
     3061 catgctgcgg gcccgcgcat cacggcggga ggaccccgca ggccacccag tgcccgatga
     3121 ggacccagat cccgctgcga gtggccaccc agaacaggag gcagtgctgg ccgactcggt
     3181 gggccgcgcc cttctggtcg tgctcgacag gctgggcccc gccgagcgcg tcgcgttcgt
     3241 gctgcacgac atgttcgcag tgccgttcga cgagatcgcc cccgtcgtgg accgctccct
     3301 ctccgctgcg aagcaactcg cgagccgggc ccggcgcaag gtacggggcg cccccgccgt
     3361 ccccggagcg gagctcgccc ggcagcggct catcattgag gcgttcctgg cggcggcgcg
     3421 agcgggcgac atcgacgcgg tcctcgcggt actggcgccc gacgccgtac gacgtgcgga
     3481 ccgcgcggcc cttccagagg gcagaccgct cgaggtgcgc ggtgcgcggg ccgtggcgga
     3541 ggagatcgtc gtcttcggac ggaacgcgca cgtcgcggag ccggtactca tcggcggcgc
     3601 cgtggggatc acggtcgcac catacggacg actgcagctc gcccttaccg tcacgaccgc
     3661 ctgcgagagg atcaccgggt acgaactcat cgccgacccg aaccgacttc aacagcttga
     3721 tctgacactc ctcgacgaag ccatccccct cggcggttag ggcaaccgcc aagtggcata
     3781 gcgatcaggt gtcgccatcg tttgccgccg agttggtcct cagccacccg agaaacgtct
     3841 tggcgaagtg gagcgtcccc tacgggtgat agcccccatg tgggcagatg gccgagggta
     3901 gagctctcgt cgtgagatct ctcccgcacc agcgtgcttc tcgtgccgtc cctaccgcgg
     3961 ttctgctcgt tggcggcttc gaaggccggc tacgaccggg tgaagaactt aggggccgcg
     4021 tggacggaca acacaagtgc ccctggcgga cacaaccact gtgacacgcg cgacgacatc
     4081 ctcaaacgcg atctcaaaga cgtgaagttc gagggcacct cgaagtgcct ggtcgcctcc
     4141 ggcaccctcg ccgaccccta caccggcaag aacatcgcct tccagcgcgg cccgaagtcc
     4201 tccgccgtgc agatcgacca cctcgtcgcc ctgtccgacg cctggcagac cggagcccag
     4261 caactcctcc aagaccacaa cgacccgctg aacctcgtcg ccgccgacgg cccggcgaac
     4321 atgggcaagg gcgacaagga cgccgcctcc tgactcccgg ccaacaaggc cttcgactgc
     4381 acctacgtgg cccggcagat cgtcgtgaag tagaagtacc acctctgggt caccccagct
     4441 gaagccaccg cgatggagaa gacgctggag acgtgccctg cacagaagct cccgactgag
     4501 tcctcgcccg gcgtcgtgct caagccctga acccctccgg cgcacgcggg ccggcgccgt
     4561 cgggagccgg aggtgccgcg ttcggttggt cgctggcaac ggcctgctcg cggcgcacgg
     4621 tcgaggacgt agtcgcggtc acggatggcc gggagcgccg tgccgagcgg cgaagtcgtc
     4681 gagggcgcgg aagcggtggt gccgactgct ccggtgcgct cgtactgctc gccaggtccc
     4741 ttgctgagca tggccagaac accgatttac gtgatcgaag agaaagggcc tggtggaggc
     4801 gtggctgccg actcgcggtt gtcggctttc ggtttcagtt ctcggtggag gtgcggcggc
     4861 gggaggcgag gaccaagccg gcgccggtgg tgagggcgat ggcggtgccg ccgattgccc
     4921 acggggtggc ggggccggcg cccgaggcgg cgagctgggc gccggtgttc tgggacggct
     4981 tggcggtgtc ctggccgggc gcgacggccg gcttggcgtc ggcgccgcgg tcgccagcgt
     5041 tgtgggtgtg ctgctcgctg gtggcgggct tgtccgcctc gccgtgcttg ccctcggtgc
     5101 cgggcgcgtg cttgttcttg gcagcgtcct tggccgcttc ctcggctacg tccttggccg
     5161 cttgctcggc gaacctcttc gcatcggcct tgtccttggc gcgggcctcg tactggccga
     5221 cctccaggaa gtaacggatg tcctccatgg tgccgtccag cgccttgttg gcggcttcct
     5281 tcaccttggg gccgccgttg tgcaggatct gcgaggtccg gacccggtcg tcgacgtcct
     5341 gagcctgctg gcggccgacg ccgaggaagt ggacccggtc ctcgggagtg ctgttgagtg
     5401 ccgcctcggc ggctttccgg acgccggggc cggagttctg gtcggaaagg atcttgagga
     5461 tggcgaagcg gttgttcttg tcggccttcg cgttcccttg tgtgtccggc ttggcgtccg
     5521 gtgctgtgtc aggggtggag ctggccggcg gcgtagcggt atcagcagcg accgccggag
     5581 aggcgaacag gacggcgggc gctatcgcgg cagccgcgac gacagttgaa atacgggaca
     5641 gcttcacgcg taccctcact ttctcgggaa agtggtagta aataactcgc aaactataga
     5701 tgggtgagga ttaccgctgt aaggggggtg ctgtcgcctt gggctggaca gggcctggcg
     5761 aagtgtcaca gccgatgcgc gagcgcaggg gcttcgtgga tgccgaattc gcggcgtagt
     5821 gccgagcggg ccgcaaggta gccgcacatg ccgtgcacgc cggggccggg gggagtggcg
     5881 gcggaacaca ggtagaggcc gcggagcggg gtgcggtacg ggtcggtctg ggggacgggt
     5941 cgggccaggc tctgcttgag cgtcatcgct cctgcaccga tgtccccgcc cacgtagttg
     6001 gggttgtacg cctcgtaggc ggcgccggtg atactgcggt gggccaggat ggtgtcggtg
     6061 aatccggggg cgtaccgctc gatctggccc cggatcaggt cgtagggatc ggtggtgctg
     6121 ccgtgcggca tgtgcgcgta cgcccatacc gggcgcttcc cgtggtgtgc tctgccgggg
     6181 tcggcgaccg ccgggtcgac gagcaggacg aacggttcgc cggtggcgat gccgcgggtg
     6241 gtgagggtct cctgacggaa gatgccggcc tgggtgccgc cgaggtgcac ggtgggggcc
     6301 ctggcggtct ccggggcggc ccacgggacg gggccggata cgaggaagtc gaccttcgcg
     6361 gcggcgggcc cgtagcggaa ccgtgccagc cgggcgcggt agcgggccgg cagccggtca
     6421 cccgcgatct gcagcaggcc cttgggggcg acgtcgagca acacggctcg ggcgggcggt
     6481 agttcacgca ggtccacgat gtgccggccg gtgtggaaca ccccgccctg ggcggtgatg
     6541 tcggcagcga gggcatcggc gatccgtgcg ctgccaccgc gcggcagcgg ccagccggtg
     6601 gtgtgtgcca gatggcccag gagcagggcg acggtggcgc cggccagggt ggggagccgg
     6661 ccgaccgcgt gggcggcgac gccggcgagg agggcgcggg cgggttcgcc ggtgaactgg
     6721 cgggtggcca gcggggtgcc gtgcgcgagg aggcgggggg cgagacggag cgcggtcgcc
     6781 gctgctcccg gcagggcccg tggcccggag aggatcagat cgaccaactc gccgctgtgg
     6841 ccgagcagtg gccgcatcag ggaccgccag cgggccccgt ccgggccgag ttccgcgcag
     6901 gtgcgttcga cgtcgtggta ggcgacggcg ctgcggccgc cggggagggg gtgggcgtag
     6961 ccggcctcgg cgcgcaggag gtccacgttc cgggtggtca ggtcgaattc ggtgaagaag
     7021 ggggatgcgg cggccatcgg gtgcaccgcg gcgcagatgt cgtggtggat gtcgctgtcg
     7081 aagaggggct tggtgcgaag tccgccgccg atggtgccgt gtgcttcgta cagctccacc
     7141 ttgagtccgg cgcgggcgag ggtcacgcct gccgcgagcc cgttggggcc ggtgcccacg
     7201 atgacggcgt cgggtgtcat gccggggcct cctgggcttc ggcgagcctg cggtagaggc
     7261 cgttgcccgc gtggagttcg gcgtgggtgc cgctggcctg cacgccgccg ccggccagga
     7321 caatgatttt ctcggcctgg gtgatggtgg agaagcggtg ggcgatggcg acgacggcgc
     7381 agtggcgggc gatgatgtcg atgctgtcgc gcagcgccgc ctccgactcc ccgtcgagac
     7441 tggcggtcgc ctcgtccagc aggacgatcc ggggccgttg cagcagcgca cgggcgatgg
     7501 cgaggcgctg gcgctgcccg ccggacaggc ccgcgccgcg ctcgccgagc tcggtgtcca
     7561 ggccgtcggg aagggctgcg atcacgtccg tgagatgcgc cttgtcgagg gcatcggcga
     7621 tctcgcgggc ggtggcgtcg ggggcggcgt aggtgaggtt ctcgcgtacg gtgccgcgca
     7681 gcagggtgtg gtcctggtcg acgtaaccga cgagggagcg cagttggccg agcggcaggg
     7741 aggcgatgtc gatgccgccc atgcggatgg tgccggatgt cggcgcgtag aggcgctcga
     7801 tgagttggaa caccgtgctc ttgcccgcgc cggaggggcc gacgacggcg gtgaggccgc
     7861 gctcggggac ggtgaaggac acgttgtcga ggacggtggt gtcgctgccc gggtaggtga
     7921 aggacacctt ctcgaagctg atgccgtgct cgtcgagggt tatgtcggag ccggggccgg
     7981 tgtcctcctg gtcgagggtg ccgagctcgg cgatccggtc gattgaggcc ctgccctgct
     8041 ggaactgggc gacggacatg aacagcatca ccagcggcga caccaggtag aagaggtaca
     8101 tcatgaaggc cgtcaggtcg gcgggtgcca tgtcgccggt ggcgacacgg gccatgcccc
     8161 aggcgatgac gacggtcagc gcgagctggg tgcccacatt catggccggg gtgagcatcg
     8221 ccgacagggc ggagacccgg atgccggagc gccgggcctg ccgggcgaga gcggagacgt
     8281 ggtcgctctc gcgcccctcc gcgcgcgacg ccttgacagt cggcagggct cccaggaccc
     8341 gcaggagggc ggagccgaag gcactggtgt cctcgcggtt ggtcaccgac acccggcgga
     8401 cctggcgggc gaggagcagg gagaccacgc tcgcgagacc gagacagctg agggtcgtga
     8461 cgagcagcag cggatcgagc cggcccatca tcgcgattcc gcccaggacc atgaaggcac
     8521 tggtgacgat ctgggccagc gcctgcgtca ggcagacccg ggccagggag gtgtcggtga
     8581 ccatccgggt gaatacatcg ccctggtccc aacggcggta cgactgcagc ctggagcgca
     8641 gcaggcgggc ggcgagggtg tgccggatgt cgtagacgac gttctcgccg gcgcggccga
     8701 tggcgtaggc gtgggcggtg gcgagggccg cgtcggtggc gaacagggcg atggccagga
     8761 ggacggggcc ggtcagcggc agatccgccg ccacggactt gatcatctcg ccgatgacca
     8821 gtggctgggc gagggtcgcc gccgcacccg cgacgccgag gaccgtcccg gtcagcagca
     8881 gggcggtgtg tccgcgggcg atctcccaga cgttcacacc gctgccttga cgtaggtggt
     8941 gacgaacatg ggggattgtt ccgtgtacgg ggtcccgtgc cagtcggcgc tacggctctc
     9001 gggccgcagg ccggcggccc gggcgtagcc gtcgacctct tccggggtgg tgagccggga
     9061 gagttcggtg ccgacgcggg tgcggccgtc ggactcgtac cagatgtgcg agcagtgcca
     9121 caggctgccc tcggtcagca ggacggaatg tgtctggaga ccggtgccgg gttccgggta
     9181 cggggtgaag tacgtggtgc gggtgcggcc ttcgtgcagc gcgaggatgg cggccttgtt
     9241 gtgggtctcc acgacgaggc gtcccccggg cgcgagcagg tccgcggcac ggtggatcgc
     9301 ccgctgctgg tcgtcggggt cgagcagcat ggacagggtg ccgcagacgc agtagacgag
     9361 ccctgcggtg tgctccgccg tgtgggtgcg gatgtcgccg tgcacgggct cgacgggggt
     9421 gtcgtcgtcg agggcggcgc gcagggcggc gagcatctcc ggtgaggagt cgatgccggt
     9481 gatccggccg acgcgtcggg ccagcggcac cgcgatccgg ccggtgccga cgccgaactc
     9541 gacggttccc gcggccggtt cggggtgcag gccggccagt cgctcggcgg tgacggtggc
     9601 ggactcgtcc ttggggaaga gccggtcgta ccagccgtcg aactgccgcc cgtagccgat
     9661 gtcgtcgacg gcgccggccg gcccgggggt ggcgatcgcg ttcaccgggt gggcttcttc
     9721 cgcttgatct ccacgccggc cgcgatgaag agggcgacac cggcgcccat cgcgatgggg
     9781 atgttgacgg tgccggtggc ggtcaggaag ccgagtacgg cgagcccgac ggccaggcat
     9841 ccggcgactg cggacttgtt catgacgttc tccttgctgc cgtcccggac ggtctgtcca
     9901 ggcggccagt acggctttgc ggactacttc ttgaggaggc cgagggcgat gacggcggcg
     9961 atcacgacgc cgacggcgat gatgatgtag ggcgccatcc tcatgcctcc accgtggtcc
    10021 cggccctgac ggccggtggg gagacggccg cccccgggtc gaacgggatg tacggcgaga
    10081 cgaacaccat ctcgggggtg tgcgtggtgt cgtagccggt ggcacgggcc agtgcgaact
    10141 ggaagccctt gatctcgcgg gcacttgtgc cccggtccag gagggtggcg cgcaggtgct
    10201 cggtgagggt gcggtatccg gcggtgcggg tgacgacggc gaagcccttg tcgatgacgt
    10261 gcaggatctc gctgcagatg tcgaagaccg ctttctcggg acgccgggtc gggaaccagg
    10321 cgatctgcca gggcttgcgg ccctcgatca cgtcaaggcc ctgccaccgc gaggtggtgc
    10381 cttccgtgcc gagggtgcgg tacacgaagt gatagtcgtg cgtcgccgga gtcggcgcga
    10441 agaagcgcca gttgggcagc atggagaagg tgtccttgag ctgcaaccgg ttgaacatgg
    10501 ggttcggatg ctggacggcg agggtactga ccagcatggc cgcgccggcg atgcgccagc
    10561 cggcaccctt gccggtgaac aggtccgcgg cggcggtgcg cggggtggtc acttgccggg
    10621 ctccattcct gtggtgggtt cggccgccgt gccgggcgcg ccggtcgtgg tgattccgaa
    10681 gaactcggtg atgcagtcgg ccacttggtg ggcgtagcgg cccatggtga ggaccgtgtc
    10741 gtggccggcg ccctcgatga cgacggtctc ggtccggccg tcgcggtggg cgtcggcgag
    10801 ttccttgtgc atcaacagtt ggtcggggtc gcggtcgacg gtctgttggg cggagacgac
    10861 gaggccgtgt gccccgtgga tggggggcag tgcaccggag aaggcccgga agtcggcttc
    10921 cacggcgttc cattcacggc gccccgcgtc ccacatccgt acgtcggcgt actgggcgaa
    10981 caccttcttg cggtaggcga cgggcagcga ctccagccag tccgggcgtg ccatgaggat
    11041 gccggtgccc agcctgaggt accaggtcat ctgggtgagc gcggtgcgca gtttgccggc
    11101 ggtgtcacgt tgctgctgcg agcggttgag ctcgtcgggg tgcgaggcgt ccaggtagac
    11161 gacaccgtgc agacggtcgc cgagctgctg ggctgcgcgg cgggctattt cgccgccgag
    11221 ggagtggccg acgaggatca ccttgcggtg tggggcgacg gccccgttga cgaggtcgac
    11281 gagatcgtcg acggactgcc cgagggtgaa gcggccgggc gagcggtagc ggctgccggc
    11341 gtaccctgcg cgggcgtagg tgaggacgcc gtgctcggtg tcctgggcca ggcgttcggt
    11401 gatccaggcg aagtgctcgc tggtggagac catgccggcg gcgaacacga agaccggctg
    11461 ggtgccgtcg cccggggaca gcacctcgta ctggagctcg ttgccgtggc gggtggtcag
    11521 cacgcgggag gtgtgccatc cctcggtggc gcgcagccgc cgctgcacgg cggtgcccat
    11581 ggcggcggcg gtggccgcgg cgagaagggc cagcgcggcg ggcagcgcgc ggtcgtcccg
    11641 accggcggcg gccgggtggc tgcgcggggt cgaggtgtag gcgaccatcg ggtgcatggc
    11701 ggtgaaggcg gtcacgaagc ggccgagccc catgaagtag ccgttggcca ggtggaaggc
    11761 ggcggcgctc gcgatgaggg ggcgggccag ccggccgccg caggcatagg cgagcgggaa
    11821 gaggcactcc agtgccagca cgccgtgggt gaggtacttg gcggctttgg ggtggtcctg
    11881 ggtccagcgg aacatgccgg ggtgaccgta ggtgcgggtg cgcatgacac cgccgagcgc
    11941 actggcgtcg cgccagggct cgccgatgag cttgacccag ccggagatga ggtacgacag
    12001 gttcgcctgt agcgcgacgt accagagcag ggcgtccttg gccggcgcgg agcgggtcag
    12061 ccgggcggca ccggtcgcgg tctgtacgag gatcgcgacc tggtcggagc cgtcggtgcc
    12121 gtagcggtgg cgcgggtaga gcagggcgga gcttgcgccg aggaagatgt ttccggcgcc
    12181 gcgccagcgg gagttgccgg gcagcagcat gccggcggcg acggtcgcgc gggtgaggtg
    12241 cagggcggtc gtggtcctcg gcccgctgac ggcgttcagc aggcggcgga cgactggtgt
    12301 ggattgggcc tggacgtcct tgacgatgtt ccagtcgttg aggccgcctt ggcgtatctc
    12361 cttgcgctgc gagaggtatt cgagggacga cgtcagcgtg gtgacggcgg tgagccgttc
    12421 ggacaggccg agggcgcggt cccggctcac cggcgcgggg gcgaataccg cggcggcaat
    12481 cttcttgacg aacttcacgt gatctctttc gcagtgcccg tggcacggac ggactggggg
    12541 cgcccggtgg gcgcatctgt gtctgccggg ccgggatccg ccgctggccc ggcagacagc
    12601 agatgcacct gttccggtca gggaacggtg ggagttgtta tccgttgcgg ccggcctcga
    12661 aggcgccgac gacggcggag gagatcgcga tgccccccat gaaggcggcc ggggtggcca
    12721 gcaccggagt ggccatgggg aagatggcgc cctcctccgg gatctccatc tcgttcgctg
    12781 cggcggcgac gtcgatcatg ttcgtgtcct ttcgggtggc cggggccggt gcggtgcccg
    12841 gacgcggcca gggtgaatgc ggtggtgctg cggaaaggga gccggccggg ccggcaggac
    12901 cggtgcggcc ccggtcagcc gaccgcgcgg ccgagggcgt aggcaccgcc gaccacggtg
    12961 gcgccgccga cgaaggcgcc gacggccttg gcgccgccga tggccgcgag agcggcggcg
    13021 ggagtcgcca ggaccggggt ctggtcggag tgggcctcgc ccgtctcgat ggctccgagg
    13081 tccaggccgt tgacgaagga aacgatctcg gtcatgcgaa tgctcgcttt cggtgttctg
    13141 ggatccaagc cgcctgacgg atcgtcagga gtgtctggcg gcagggggat acaagcaccc
    13201 atgtgcagaa atgaggtatg gcgcaggtca caggaaaatg cggagcgcgc cttagtgatc
    13261 actgacagtt gtcacgtgtg gccgtgacag gtgtcatacg aacccatgag gctgttcact
    13321 atgcaaagag tctataaatg gcaaagattg agccatggaa gtcaatgaac agcaaaatgt
    13381 gatcgatgcc atagggctct ggcgccggta cggaggcgat ggggagcgcg gattcgacgc
    13441 ggtccgcggc atcgacctca ccgtcgcgca aggcgagctg ttcgccctgc tgggcaccaa
    13501 cggggcgggc aagacctcca cggtcgaact cctcgaagga ctggcaccgg ccaccaaggg
    13561 cacgatcaga ctgttcggca acctcgaccc cgtacgcgac cgggcaaggg tgcgcccccg
    13621 caccggcgtg atgctgcaac agggcggctt ccccagcgac ctgaccgtgg cggagacgat
    13681 ccggatgtgg gcgtcctgca ccacggcgcc ccgcccggac gccgaagcgg ccgccatggt
    13741 gggcctgacc ggacgcaggg acgtcgcggt caagaacctc tccggcggcg agcgacggcg
    13801 cctcgacctg gctctcgcca cactcggccg gcccgagctg ctgttcctgg acgagcccac
    13861 caccgggatg gatcccgagg gccgccatga cacctggcgg accatcgagg agctgcaggc
    13921 cgagggcacc accatcgtgc tcaccacgca tcacctcgaa gaggccgagc ggctcgccga
    13981 ccggctggcg atcatgcacg ccgggcagat cgcggtgacc ggcacggtcg ccgcgatcgt
    14041 cgccgcccat ccctccaccc tcggcttccg cctcccaccc ggcctcaccc ccgacgacct
    14101 gccgcactcc gccgtactgc aggcggaagt caccgtcgcc accgaccgcg tcgaactcct
    14161 caccgaccag ctgcaacaca ccgcgaccga ggttctcaac tgggcccggg acaggcagct
    14221 cgaactggag gagctgcacg ccagttccgc ctcgctggag gaggcgttcc tgcgcatcgc
    14281 ccggaaggaa acgaaggaac ccgtatgagc aacgccacca cgcacctcgc cgcgctctcc
    14341 agggtcgaac tcaccctctt cctgcgcagc aggagcaacc tgttcaacgt cctggtgatc
    14401 cccgccatga tcaccatggg caccacgacg gtcatgaagc agttcgacct cgaaggggcc
    14461 gggctcgcca tgggccaggt catgatctcc accagtgccg gaatcgtcct ggtcatggcc
    14521 ttgtacgcgc cgctcgtcgg gacctatgta ctgcgccgcg aggagcacgt tctcaaacgc
    14581 ctgcgcaccg gagaagtcag cgacctcgtc atcctggcca gccctgccgt gcccatgacc
    14641 atggcggccg ttttccagtt cgccctgata gccaccgcgg tttcggccat cgccgggctc
    14701 ggcgcaccgg ccgccccgca cctggtcctg ctcggcgtgc tgctcggcgc ggtcctcacc
    14761 gccgccatcg ccgcactcag caccgccgcc gcccgcaccg cggaaagcgc acaaggcatc
    14821 agcaccatcg gcttcctgct gctcctgctc acctccggca cactcgttcc gctggaggtg
    14881 ctccccgacg ccatgggcga cgtactgcgc ttcttcccgc tcacccccgt caccgaactg
    14941 gtgcgttccg gttggacggg gcagcacgcc ggcccggccg acacattgat cgcgatcgtg
    15001 acgctactgg cctggacggc tctcgccgcc tggggcgcac accgcaactt ccgttgggaa
    15061 ccgcgcacgt gagtacggca tcgggtgctg cgcaggcccg ccaccagatc gacgtgaagc
    15121 gggccaccgc gcacacccgc tggatgctgt gcctcattcc gtggctgctg ctcgcctccc
    15181 tgctctggcc gctcctctcc cacctggacc atgcggacgc cgaccggctc ccgcccgcca
    15241 tcggctgggc catcgccacg ctcaccgcgc tgcaagggct cggcgccacc accgccgtcg
    15301 cctacagcat cggccgggcc agacactccg ccaccctcat cggcgccatg gcggccgtga
    15361 cactgctcga actggccctg cttccctggg cccacgacgt cggcctgctc gacagcaccc
    15421 gcagcctgat cccggcctcc atcatggtgg cgctgcccct gtcgttcgcc ctgtcctccg
    15481 ccatggggcg ccgcgcctac acggcggtgg ccgtcggcga gtcggtcctg gccggcggcg
    15541 cagtcctggt cgccgaccgc gccgccgccc ccgccgtcct ggcgttcacg gcggccacct
    15601 gggtcgtcat cggaagcctg atgcggtcct cgatgtggtt cctcaccgtg ctgtggcagt
    15661 tgaacgccgc ccgcgaggcg cagacacggc tcgtgatcgc cgaggagcgc ctccgattcg
    15721 cgcgagacct gcacgacgtc atcggcagcg acctctcggt gatcgctctg aaggccgaac
    15781 tcgcggagcg cctcgcgcag gcccccgagg cccggtccga gatggcccac gtgcagagcc
    15841 tcacccgcgg tcttcaccac gagatcagag aagtggtcaa cggataccgc accaccgatc
    15901 tgaccaccga gttgcagggg gcccaagccg tgctggaagc cgcgggcgtc tcctgccgca
    15961 tccaccggga gggcgatgtc cctctgccac aggaagccca gaccgccctc ggctgggccg
    16021 tccgcgaagg cgtcaccaac gtgttgcgcc atgcgcaggc gagtacctgc accatccggc
    16081 tcaccgggac cgggcacggc cccacccgcc tggacatcat caacgacgga accggccagc
    16141 agaccgcgtc cgagcgcggc aacggcctgg ccgggctcgt cgaacgactg gcaccgctcg
    16201 gcggaaccgt gagccacggc cgcgaagccg gccccaccta ccgactcacc gtgcaccttc
    16261 cgagacagga caaccgatga tccgcattct cctggccgac gacgagcacc tcatccgagg
    16321 cgccttcgcc gcactgctcg ccctggagga agacctcgac atcgtcgccg aggcggccac
    16381 cggccccgaa gccgtcacca tggcgctgcg ccacaagccg gacgtcgccg tgctcgatct
    16441 ccagatgccg ggcaaggacg gcgtggccgt cgtcgaggaa ctcaccacat ccctcccgga
    16501 ctgcaagacc atgatcgtca caagtcacgg cctgcccggc cccctcaaac gcgccctgac
    16561 ccacggcgtc aagggcttcg tcctcaaaac cgtctccgcc caccaactcg ccaccatcat
    16621 ccgcaccgtc aacgccggca accgctacat cgacccgata ctcgccgccg acgccatcag
    16681 cgcaggagcg tccccgctca gcgcccgcga ggcggacatc ctctccttgg caaccgacgg
    16741 cgccccgatc gaggaggtcg ccgaacgagc cgccctggca ccggggaccg tccgcaacta
    16801 cctgtcctcc gccaccacca agctgggcgc cgagaaccga catgcggcag tgcacgtagc
    16861 acagcaacgc gggtggatct gacgcatgtg atgcatgtga tgcaagcccg taggcgcccg
    16921 caggcaaatg aggccggctc ccgctgccca cggccaggca cacagcccac gcccgggacc
    16981 ggccgcaggc ccgtaggccc caggcagtgg gatggggctg ctgtgccggt ctgtccggcg
    17041 gacgctgcgt caggcaagtc ggtttgtcgt cgggcttgcc gctgctcgac gcgccaggag
    17101 aagccggcgc cccgccgaag ccggcgcagc gcgcgccgat ctacaaggac cagcgcatca
    17161 cgctgcccga gcccagcatg cagcaatgcg gccagttctc agtcgacttc gacacaccgc
    17221 gcgggcatga ggactcggac atcaggaagg cggattcggt gacgtcaccg cagagcgcga
    17281 ttccgccagg taggcgtgaa cagcgggttc gggaactcgg acggaccggc ctacgcggat
    17341 tgcgacgcgc tcgggagtga gggacctctt agtggacggt tcgtgagtct ttgagtcgtt
    17401 ctgtggtcgc ctgatggtgt gaggcggggg cggaaaccgc ggattcgtgg tgcggggtct
    17461 gctggggttg gcggggtgag tgaacgcaag ccgtacccca gcgacttatc ggacgagcag
    17521 tggtcgttga tcgagccggt gatcaccgcg tggaaggacc ggcaccgctc ggtcagcggt
    17581 catcagggcg cttacgacat gcgggagatc gtgaacgcga tcctctatca ggggcggacc
    17641 ggctgtcagt gggcctacct tccgcacgac ctgccgcaga agagtgcgac gtactactac
    17701 ttcgccgcct ggcgggacga cggaaccgac caggtcattc atgaactcct gcgctgccag
    17761 gtccgtgaac gcgcccgccg attagaggac ccgaccctgg tggtgctgga cacccagagt
    17821 gtccacgcgg ccgtcggggt ccccgccgcc acgaccggct acgatccggc caaacgagtg
    17881 ccgggccgca aacgcggcgt ggcagttgac gtcctcggcc tggtcatcgc ggtcgccgtc
    17941 ctcgccgcga acgtccacga caacaccgcg ggcatcgccc tgctggacca ggtcgccgag
    18001 cacaccggcg acaccgtccg caaagccctg gtcgaccagg gcttcaagaa ccaggtcgtc
    18061 gaacacggcg ccggcctggg catcgacgtc gagatcgtcg aacgcgaccc cggctaccgg
    18121 ggattcctgc cgcaaccgaa gcggtggaga gtcgagcaga cctacggcat cctgatactg
    18181 caccgacgcc tggtccgtga ctacgagcac cgcaccgcct cgtccgcctc ccgcgtctat
    18241 tgggcgatgt cccatgtcat gatccgccgt ctcaccggca cgaacacctc cacctggcgc
    18301 gaggaggcgg taagcgcgtg aacgttcgcc ccctccttga ggcactggac ctgcaagagg
    18361 aagccgcccg ggccctggct gacgaccttc gcgcgcagat cgacgacctg cagacccggc
    18421 tgcgggaggc cgagacacac ctcgagcacc tcgcgatcac ccgcaagacc gtcaccagcc
    18481 tcgccgacca gctccccgca cccccacccg aactgcccga gcacccggac tacccgcgca
    18541 tcctcgccgc cttcaacgag tcgaccggcc ccctgcgagc caaggacgtc tgccaggccc
    18601 ttggccacga actgctgccg aagaacgtcg aaggcacccg ggccaaactg aagcgcctgg
    18661 tcaaactcgg catcctcacc gaagccgaca ccggctgctt tacccggcga cagtagccgg
    18721 caccgcggcc agcacacctg tcccaagcct cacttcgaaa cggacatcaa ctcacgaacc
    18781 gcccacttag agatcagtcc gtgctcgatc gggtcgagac aggaattgcc ggtcaccttc
    18841 ggtactcaag tcggcggcat ttctcaacct tgaacgccgg tagggggctg gctactgggg
    18901 tcggccgaag tacaggcttc gggtgtactc gttgagctgt ccgccgggtg ccgagttgta
    18961 ggacatggtg gcgctgatcc gtggtgtcgt gccctctaca ggggtgacgc ggtgcatgga
    19021 gttcctgccg gagtgcagga cgagcgtgcc ggggacagtg ggcagctcgt ggatcagcgg
    19081 atgccgctcg cccccggcga tggcgcgcag ttcggcctgg tcctgttcgg cccgagcgcg
    19141 cgagcggggc acgtattcga gtacgccgcc gctctcgggc gccaggatgt gcaggacgat
    19201 cgtgtactgc gacacatcga agtgccagtc ctgctcgtca cggtcgtggt gcacgtggac
    19261 ggtcatggcg cccagcggat cggcggagcg gtacaccggt tcgcccacga cccggcggac
    19321 gaacgcgagc accggctcgc tgcggtagag cgccttgagc ggtgaggact cgtcgatgcg
    19381 gtcgtaggcg agggtcgtct tggtgtgctc gcggcccact tgtccgtgca ccggggcggc
    19441 gggctcgccc gtgccgagga acacgtcgtt gctaccggtg aaccggaagc cgaggctctc
    19501 cgcgtccttg agtgaccggg tcgccacctg ccggactgcc tccggccgga ggaagtcgtc
    19561 caggaccacc agactggtgt cgttgaacga tgcccgtgcc tcgtcgacca gcgctcgtcc
    19621 ggccgagcca tccagttccg aaacgggata cttctccaga ttgacccagg gagccagctc
    19681 cgtagcgacg tgcgtcatga gaacctccag ccgtcggcgc aacgcccggc cgttccatac
    19741 cggggtctcc tgactgctcc acgcaagtac cgcatgcctc taccccagcc acccccctgt
    19801 actccgcatg ggtgcctcgt attccggccg tgcgtcacac ttcggacagg cgtgctgttc
    19861 gacgtcgccg gcatccgacc ggtcccaggt caggatgtct gtgctcgggt gggtacgccg
    19921 tgcagggagt cgaggagctc tccgaatgtg atcctctctt cgtcgtacgg gaaggacatg
    19981 gcggcggcga gtgccgtcca ccggtcggtg ctgcgtccgc agtggtccag cagcatcttc
    20041 agtacgacct cgggttcgtg gcggcagagg atctcgtcgg cggggatctg gcgcagatgc
    20101 tccggggtgt ggtggcggga tttgacgact gctcggtaga tatcggagcg ggagagcatc
    20161 tcatcggcgg cggggaagtc gagccaggac tgcaggacgg ctgcgggggc ggggtgcttg
    20221 ccgagctcgt cgtcgctcag cagccgcagc acaccgtcgt cttccccctc tgcggccggg
    20281 acggccgccg ccgtgttgat gaaccagtca gggctttcga ccttctcggc gatccagacc
    20341 agctcggcgg ggtgcagcac ctggaggacg tcaccgacgg cggcgtgcgg ggtgtgaggg
    20401 ttggcggcga gggcggccag ggtctcggcc cggcggtgct ccgagtggcg ctccaggagc
    20461 cgggctggac ggtcgtagtc agggtcaagg ttgtcgtcga cgacgcggat cagtgtccgg
    20521 ctcggcgcgg gggacacgac cgtcggcggg tccatggagg cgagctgagc gcaggcttct
    20581 acgagatggt cggggttggc gctgaggagg gc
//
