LOCUS       NZ_CP054019            20684 bp    DNA     linear   CON 28-JAN-2024
DEFINITION  Streptomyces sp. A1-5 chromosome.
ACCESSION   NZ_CP054019
VERSION     NZ_CP054019.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. A1-5
  ORGANISM  Streptomyces sp. A1-5
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9459690)
  AUTHORS   Dashti,Y., Sumang,F.A.M., de los Santos,E.L.C., Alcantara,E.P. and
            Challis,G.L.
  TITLE     Structural revision and biosynthesis of polyketides FXJ15321 and
            FXJ15322 from Streptomyces sp. A1-5
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9459690)
  AUTHORS   de los Santos,E.L.C.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAY-2020) Warwick Integrative Synthetic Biology
            Centre, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL,
            United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: JUN-2019
            Assembly Method                   :: Flye v. 2.4.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology :: Oxford Nanopore MiniION; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/28/2024 04:28:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,328
            CDSs (total)                      :: 8,230
            Genes (coding)                    :: 7,847
            CDSs (with protein)               :: 7,847
            Genes (RNA)                       :: 98
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 74
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 383
            CDSs (without protein)            :: 383
            Pseudo Genes (ambiguous residues) :: 0 of 383
            Pseudo Genes (frameshifted)       :: 156 of 383
            Pseudo Genes (incomplete)         :: 280 of 383
            Pseudo Genes (internal stop)      :: 26 of 383
            Pseudo Genes (multiple problems)  :: 73 of 383
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:08:01
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6362512
            Orig. end                         :: 6383196
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP054019.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Philippine National
            Collection of Microorganisms.
FEATURES             Location/Qualifiers
     region          1..20684
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="CDPS"
                     /region_number="21"
                     /rules="CDPS"
                     /tool="antismash"
     cand_cluster    1..20684
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="CDPS"
                     /kind="single"
                     /product="CDPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20684
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="False"
                     /core_location="[10000:10684](+)"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10684
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
     gene            866..2029
                     /locus_tag="HRD51_RS28160"
                     /old_locus_tag="HRD51_27810"
     CDS             866..2029
                     /EC_number="7.4.2.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0015833 - peptide transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602978.1"
                     /locus_tag="HRD51_RS28160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_27810"
                     /product="dipeptide ABC transporter ATP-binding protein"
                     /protein_id="WP_205366756.1"
                     /transl_table=11
                     /translation="MTEKTEKPEAAAKPEQAENAEQAERVESAEQTEKAEPAGRAAQDE
                     PLLRVRGLVRHFPITKGLLKRKVGAVQAVDGIDFDVFPGETLGVVGESGCGKSTMGRLI
                     TRLDEPTGGSVEFEGQDITHLSPGRLRPLRRDIQMIFQDPYGSLNPRHTIGGIVSTPFR
                     LQGVEPEGGVKKEVQRLLELVGLSPEHYNRYPHEFSGGQRQRIGIARALALKPKLVVAD
                     EPVSALDVSIQAQVVNLMDDLQEELGLTYVIIAHDLSVIRHVSDRIAVMYLGKIVELAD
                     RDSLYASPRHPYTKALLSAVPVPDPKRRTQRGRILLKGDVPSPINPPSGCRFRTRCWKA
                     TEECTTTEPPLIQLRTGHQVACHHPEGESDNSGTATESSDGKASTGQ"
     gene            2129..3538
                     /locus_tag="HRD51_RS28165"
                     /old_locus_tag="HRD51_27815"
     CDS             2129..3538
                     /EC_number="3.4.11.-"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008237 - metallopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018539214.1"
                     /locus_tag="HRD51_RS28165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_27815"
                     /product="M1 family metallopeptidase"
                     /protein_id="WP_205366757.1"
                     /transl_table=11
                     /translation="MALSRSARRSSRWLALATAVASAATIAAAPAATPGAPGIGDPYFP
                     GLGNGGYRPLHYDLGVSYHPDSGRLDGRTTLTARATQDLSSFDLDLQKLTVDQVRVDGR
                     PARFSRTGDELVIRPGRPLARGERFAVTVVYHGVPQPLSGPIVFGSQYGWMKTKDGVFV
                     ACEPNAASTWFPSSDHPDEKATYDIRIDAPKGLTGVSNGRLVGSGEHGDRAWFHWRESR
                     PMAPYLATATIGKFDVRTGTTPGGTPIYVATDPTLPTGKVDVYGVTAAATDYWSKVFGP
                     YPFEETGAIVDDMPQAGFSLEVQSKPAYSAVRSESTIVHELAHQWFGDSVSVRQWKDIW
                     LNEGFATYAQWLWAEHKGTATAHDAFRKAYQGIPADDAFWKIKVSDPQRDTMFSDAVYE
                     RGAMTLQALRERIGDRAFFRLLPAWTARHRYGNADTADFIALAEKISGQRLGDLFHTWL
                     DTQSRPALSER"
     gene            complement(3543..4175)
                     /locus_tag="HRD51_RS28170"
                     /old_locus_tag="HRD51_27820"
     CDS             complement(3543..4175)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602976.1"
                     /locus_tag="HRD51_RS28170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_27820"
                     /product="trimeric intracellular cation channel family
                     protein"
                     /protein_id="WP_205366758.1"
                     /transl_table=11
                     /translation="MLHVLYLIGVAAFAASGVLAAYRANMDPFGGLVLAFAASISGGTL
                     RDLILDRRPLYWTHDWVLLTVIICVGVGTIVYLRFWSLPRKSLLVVDAIGLSVVTVIGA
                     RAAISAGATPLAVIILAVLTGVAGEVLRDVLCGEFPPLLLREDVYAIAALAGACCYLLM
                     DRLGAGANPAAVVSAGLVFALRMGALYLGLHLPRPQQLRGRGREDAG"
     gene            4292..5170
                     /locus_tag="HRD51_RS28175"
                     /old_locus_tag="HRD51_27825"
     CDS             4292..5170
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571841.1"
                     /locus_tag="HRD51_RS28175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_27825"
                     /product="thioesterase family protein"
                     /protein_id="WP_235094445.1"
                     /transl_table=11
                     /translation="MASVTVGNSEFDRDTAVTRSAPGVYDAHLSEGWTIINAVNGGYLL
                     ALMGRALGDALPHPDPLTVTAHYLTASVPGPAVVRTEVIRTGRTLSTGTATLVQLADDG
                     SEVERMRVLATYGDLATLPDDVRTTAKPPAIPPYEHCLGTSPTPERRGGTPIAPDGRPA
                     IPGSTAIAGRLDLRLDPATAGWAVGAPSGKGEMRGWFGLADGRDPDPLSLLLTVDALPP
                     TAFELGLRGWVPTVELTCHVRHRPAPGPLRVAITTRNLAGGFLEEDAEVWDSEDRLVAQ
                     SRQLARTILVR"
     gene            5376..6545
                     /locus_tag="HRD51_RS28180"
                     /old_locus_tag="HRD51_27830"
     CDS             5376..6545
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_5 (1-372). E-value: 3.2e-71.
                     Score: 232.1. Matches aSDomain:
                     nrpspksdomains_HRD51_RS28180_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003966104.1"
                     /locus_tag="HRD51_RS28180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_27830"
                     /product="cysteine desulfurase family protein"
                     /protein_id="WP_235094446.1"
                     /sec_met_domain="Aminotran_5 (E-value: 2.5e-65, bitscore:
                     219.7, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVYLDHAATTPMLPEAVQAMTAQLTVTGNASSLHAAGRRARRTVE
                     EARESLAASLGARPSEVVFTAGGTEADNLAVKGLYWSRRAADPARTRILVSPVEHHAVL
                     DAVEWLAEQEGATVDWLPVDQYGRVHAEALREAIARNPADVALATVMWANNEIGTVQPI
                     RELAEVAREFAIPLHADAVQAVGQLDVDFTASGLAAMTVSGHKIGGPYGIGALLLGREH
                     APVPVLHGGGQERHVRSGTLDTPAIAAFAAAGRHAVAHREEFAREIGTLRDDLIKAVKA
                     AAPDAVLGGDPDPAGRLPANAHFTFPGCEGDSLLLLLDAQGIACSTGSACTAGVAQPSH
                     VLLATGMSQDLARGTLRFSLGHTSTAQDVAALAEVIGPVVERARGAGLS"
     aSDomain        5379..6491
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HRD51_RS28180_Aminotran_5.1"
                     /evalue="3.20E-71"
                     /label="HRD51_RS28180_Aminotran_5.1"
                     /locus_tag="HRD51_RS28180"
                     /protein_end="372"
                     /protein_start="1"
                     /score="232.1"
                     /tool="antismash"
                     /translation="VYLDHAATTPMLPEAVQAMTAQLTVTGNASSLHAAGRRARRTVEE
                     ARESLAASLGARPSEVVFTAGGTEADNLAVKGLYWSRRAADPARTRILVSPVEHHAVLD
                     AVEWLAEQEGATVDWLPVDQYGRVHAEALREAIARNPADVALATVMWANNEIGTVQPIR
                     ELAEVAREFAIPLHADAVQAVGQLDVDFTASGLAAMTVSGHKIGGPYGIGALLLGREHA
                     PVPVLHGGGQERHVRSGTLDTPAIAAFAAAGRHAVAHREEFAREIGTLRDDLIKAVKAA
                     APDAVLGGDPDPAGRLPANAHFTFPGCEGDSLLLLLDAQGIACSTGSACTAGVAQPSHV
                     LLATGMSQDLARGTLRFSLGHTSTAQDVAAL"
     gene            complement(6542..7186)
                     /locus_tag="HRD51_RS28185"
                     /old_locus_tag="HRD51_27835"
     CDS             complement(6542..7186)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018891305.1"
                     /locus_tag="HRD51_RS28185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_27835"
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="WP_235096116.1"
                     /transl_table=11
                     /translation="MLLLGGGAAVAAGAAAVAAREELAYWWGQLPGNSRPRKEGEVDFA
                     GAQWSAASPANYRQANRPDDYTVDRVVIHVVQGSFATALKVFRDPFHEASAHYVVRGDG
                     HIAQTVRELDVAFHAGNRGYNERSVGIEHAGFVDRPESFTPDMYAASARLTAGICHRYD
                     FPADREHVVGHIEVPGTDHTDPGPHWDWDRYLTLVRAELRRPAARTRPGTT"
     gene            7382..8509
                     /gene="mnmA"
                     /locus_tag="HRD51_RS28190"
                     /old_locus_tag="HRD51_27840"
     CDS             7382..8509
                     /EC_number="2.8.1.13"
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016783 - sulfurtransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0008033 - tRNA processing [Evidence IEA]"
                     /codon_start=1
                     /gene="mnmA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005311592.1"
                     /locus_tag="HRD51_RS28190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_27840"
                     /product="tRNA 2-thiouridine(34) synthase MnmA"
                     /protein_id="WP_205366761.1"
                     /transl_table=11
                     /translation="MTDAAAPRRLRVLAAMSGGVDSAVAAARAAEAGHDVTGVHLALSE
                     NPTSFRTGARGCCTIEDSHDARRAADVIGIPFYVWDLAERFREDVVEDFIAEYEAGRTP
                     NPCLRCNEKIKFAALLDKALALGFDAVCTGHYAQVVLREDGSRELHRATDMAKDQSYVL
                     GVLDDRQLAHAMFPLGDTPTTKTEIREEAARRGLFVAKKPDSHDICFIADGDTQGFLAK
                     RLGSAEGDIVDESGTKLGTHEGAYGFTIGQRKGLRIGTPAADGKPRYVLDISPVNNTVT
                     VGPVESLDVTALTAIKPRWCGRPPADGPAVYTAQLRAHGGETEVTAEVVGEELRVSFTE
                     PVRGVAPGQAVVLYDGTRVVGSATIATTRRAASVA"
     misc_feature    8771..8791
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.37"
                     /tool="antismash"
     misc_feature    complement(8828..8842)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.44"
                     /tool="antismash"
     misc_feature    complement(8835..8849)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.91"
                     /tool="antismash"
     misc_feature    8842..8856
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.48"
                     /tool="antismash"
     gene            9100..9651
                     /locus_tag="HRD51_RS28195"
                     /old_locus_tag="HRD51_27845"
     CDS             9100..9651
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1159: dihydropteridine reductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016572569.1"
                     /locus_tag="HRD51_RS28195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_27845"
                     /product="nitroreductase family protein"
                     /protein_id="WP_235094447.1"
                     /sec_met_domain="PF00881 (E-value: 5.2e-13, bitscore: 48.3,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDAWTVLKTRTAVRNYAKEPVDDALIEQLLEAMLAAPTASNRQA
                     WSFMVVRRPAAVRRLRAFSPGVLGTPAFFVVACVDRSLTDNLSPKLSQKIYDTSKLCVA
                     MAVENLLLAAHAAGLGGCPVGSFRSEIVKSMLGIPEHIEPMLVVPIGRPATDLVPSQRR
                     AKNEVVNYESWGNRAAAPTA"
     gene            9611..9928
                     /gene="albB"
                     /locus_tag="HRD51_RS28200"
                     /old_locus_tag="HRD51_27850"
     CDS             9611..9928
                     /codon_start=1
                     /gene="albB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_039632579.1"
                     /locus_tag="HRD51_RS28200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_27850"
                     /product="albonoursin biosynthesis protein AlbB"
                     /protein_id="WP_235094448.1"
                     /transl_table=11
                     /translation="MNPGETVLPPQLREEIALLAVYLLSSGRGLLEEPADYGIYRCTDG
                     ARRALQLLDEHGGSTARLTAVRERLDEVMFAPMGEDRDMGEILDDLCRQMADALPEIET
                     P"
     gene            10001..10684
                     /locus_tag="HRD51_RS28205"
                     /old_locus_tag="HRD51_27855"
     CDS             10001..10684
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) CDPS:
                     CDPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR04539.1"
                     /locus_tag="HRD51_RS28205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_27855"
                     /product="tRNA-dependent cyclodipeptide synthase"
                     /protein_id="WP_268826457.1"
                     /sec_met_domain="CDPS (E-value: 9.2e-67, bitscore: 223.8,
                     seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MREEILGDRSRMIRQRGEHALIGISAGNSYFSQKNTIMLLQWAGQ
                     RFERTDVVYVDTHIDEMLIADGRSAQEAERSVKRTLKDLRRRLRRSLESVGDHAERFRV
                     RSLSELQETPEYRAVRERTDRAFEEDAEFATACEDMVRAVVMNRPGDSVGLSAEHLRAG
                     LNYVLAEAPLFADSPGVFSVPSSVLCYHVDTPITTFLSRRETGFRAAEGQAYVVVRPQE
                     LADAA"
     gene            10887..11615
                     /locus_tag="HRD51_RS28210"
                     /old_locus_tag="HRD51_27860"
     CDS             10887..11615
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602959.1"
                     /locus_tag="HRD51_RS28210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_27860"
                     /product="VC0807 family protein"
                     /protein_id="WP_205366765.1"
                     /transl_table=11
                     /translation="MTQAATATATTSQGRALLQSLTPLLVDAAIPLGSYFLLAEGFGMS
                     TVAALAWSSVVPALRTIWGLARERTVNGLALLILVVNVVGLATSTLTGDARLMMAKDSG
                     VSSVVGIAILLSVRGRRPLMTAGLRPWVTKGGPEGNAAWDRLWAGSARFRQLERRFSTV
                     WGSALLIECVVKAVGAYVLPVHTMVWLGTVLTVVAILLAMVVAGGSCAEPMEQMVKAEV
                     RAAGEAAAAGNAEPAPAAAA"
     gene            11803..13179
                     /gene="gdhA"
                     /locus_tag="HRD51_RS28215"
                     /old_locus_tag="HRD51_27865"
     CDS             11803..13179
                     /EC_number="1.4.1.4"
                     /GO_function="GO:0016639 - oxidoreductase activity, acting
                     on the CH-NH2 group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0006520 - amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="gdhA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018539207.1"
                     /locus_tag="HRD51_RS28215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_27865"
                     /product="NADP-specific glutamate dehydrogenase"
                     /protein_id="WP_205366766.1"
                     /transl_table=11
                     /translation="MSTVHTGVTQSGLTAELASLHAELVRRNPGEAEFHQAALEVLETL
                     APVLTARPEFADAKVLERMVEPERQIMFRVPWQDDSGKIRVNRGFRVEFNSALGPYKGG
                     LRFHASVNLGIVKFLGFEQIFKNALTGLNIGGGKGGSDFDPHGRSDAEVMRFCQSFMTE
                     LHRHLGEHTDVPAGDIGVGGREIGYLFGQYRRITNRWEAGVLTGKGLAWGGSKARTEAT
                     GYGNVLFTEEMLKQRGEELDGQQVVVSGSGNVAIYTIEKAQALGANVLTVSDSGGYVVD
                     EKGIDLALLKQIKEVERGRVGDYAQRRGSSAKYVAGGSVWDVACDVALPSATQNELDAD
                     AARILVRNGVKAVSEGANMPTTPQAVALLKEAGVAFGPGKAANAGGVATSALEMRQNSA
                     REAWPFERAEGELAAIMRGIHDTCHQTAERFGRPGDYVAGANIAGFERVADAMLDQGLI
                     "
     gene            13281..13823
                     /locus_tag="HRD51_RS28220"
                     /old_locus_tag="HRD51_27870"
     CDS             13281..13823
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lysine_decarbox"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014055088.1"
                     /locus_tag="HRD51_RS28220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_27870"
                     /product="TIGR00730 family Rossman fold protein"
                     /protein_id="WP_205366767.1"
                     /sec_met_domain="Lysine_decarbox (E-value: 6.2e-34,
                     bitscore: 115.9, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNICVFCSAADLDDRYVVPAREFAESIGRRGHALVWGGSDTGLMK
                     VMADGVQEAGGKLLGVSVEFLADKTRANADEMVVTKDLAERKAQLLARADAIVVMVGGT
                     GTLDEATEILELRKHGMHSKPVVLLNTAGFYDGLKAQFERMEAEGFLPVPLSELVFFAE
                     DGAGALAHLEAWEAAAG"
     gene            13859..14548
                     /locus_tag="HRD51_RS28225"
                     /old_locus_tag="HRD51_27875"
     CDS             13859..14548
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (1-172). E-value: 2.7e-12. Score:
                     38.9. Matches aSDomain:
                     nrpspksdomains_HRD51_RS28225_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602956.1"
                     /locus_tag="HRD51_RS28225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_27875"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_039632571.1"
                     /sec_met_domain="adh_short (E-value: 2.9e-29, bitscore:
                     101.2, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGTHLITGAGSGIGAAVARRLAERGEELWLLARDVGRAKELAERF
                     PGAHTLVGDLATPEKLDWALGHQRLPERLDSIQHIAGVIELGAVGDLPAKAWQRQLAVN
                     LVAPAEITRLLLPLVRIAKGDVVFVNSGAGLTANPNWGGYAASKHGLKALADALRAEEH
                     DNGVRVTSIYPGRTATPMQESTHRQEGKAYDASRWIDPESVATAILTAIDLPRDAEIKD
                     LVVRPGR"
     aSDomain        13862..14374
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HRD51_RS28225_PKS_KR.1"
                     /evalue="2.70E-12"
                     /label="HRD51_RS28225_PKS_KR.1"
                     /locus_tag="HRD51_RS28225"
                     /protein_end="172"
                     /protein_start="1"
                     /score="38.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="GTHLITGAGSGIGAAVARRLAERGEELWLLARDVGRAKELAERFP
                     GAHTLVGDLATPEKLDWALGHQRLPERLDSIQHIAGVIELGAVGDLPAKAWQRQLAVNL
                     VAPAEITRLLLPLVRIAKGDVVFVNSGAGLTANPNWGGYAASKHGLKALADALRAEEHD
                     NGVRVTSI"
     CDS_motif       13865..13933
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HRD51_RS28225_0001"
                     /evalue="2.40E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="HRD51_RS28225"
                     /protein_end="25"
                     /protein_start="2"
                     /score="23.4"
                     /tool="antismash"
                     /translation="THLITGAGSGIGAAVARRLAERG"
     gene            14649..15113
                     /locus_tag="HRD51_RS28230"
                     /old_locus_tag="HRD51_27880"
     CDS             14649..15113
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571833.1"
                     /locus_tag="HRD51_RS28230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_27880"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_235094449.1"
                     /transl_table=11
                     /translation="MTTSRATTEAKTTAAAECGFREIRGLVTELSRRLDAHQRSRIAEL
                     DLTPTQAKALEELGEPKTARELAAVLCCEPPNVTYVISKLEKQGMVVRRPHPADGRAKQ
                     LVLTEAGRELRLDLLRRMGTESPLDHLSHEERSALRDELLRALGRATDAA"
     misc_feature    15193..15208
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 16.92"
                     /tool="antismash"
     misc_feature    15196..15209
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.34"
                     /tool="antismash"
     misc_feature    complement(15216..15234)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.31"
                     /tool="antismash"
     misc_feature    15225..15245
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 21.07"
                     /tool="antismash"
     gene            15247..16647
                     /locus_tag="HRD51_RS28235"
                     /old_locus_tag="HRD51_27885"
     CDS             15247..16647
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571832.1"
                     /locus_tag="HRD51_RS28235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_27885"
                     /product="MFS transporter"
                     /protein_id="WP_205366768.1"
                     /transl_table=11
                     /translation="MITENAAPRATASTPTRPAPAGGAAQLVVLALGFVMASLDTGIMN
                     VAAHDLRARLGLTMSGLTWVVDGYVLAFAALLLLAGSLAKRFGARRIYLVGLAVFTAAS
                     LLGAAAPGGGALVAARFAQGAGAALFMPSSLSLLMNAFPEPARRAKVLGIWSAIVSTSV
                     GLAPTVGGLLVGTLGWRSIFLVNLPIGIAGLLLTRRVIAAVPGTGAPLGGTGHVLGLLA
                     LGSLSYALIEGPAAGWAAPGVLAAFAVTVLAAAGFVVRERTARTPVLPVTLFADSRFSA
                     ANAVGFLFNFAFYGALFVLGLFLQTGRGADAVTAGLQMLPAVLVIPIGNVLYTRIAPRT
                     GNRAALAVSLALSAAGYLLLFLVLSPTLPYGVIAVVLAVTNIGSGISSPAMTGVLMEAA
                     GREHADIGSATLNANRQVGSLVGIAGMGAILTGAGDAYQGTGYAFALTAAALAAAAVVG
                     WLGVRGRR"
     gene            16738..17751
                     /locus_tag="HRD51_RS28240"
                     /old_locus_tag="HRD51_27890"
     CDS             16738..17751
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018087257.1"
                     /locus_tag="HRD51_RS28240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_27890"
                     /product="methionine synthase"
                     /protein_id="WP_205366769.1"
                     /transl_table=11
                     /translation="MSENTRHKWAAGAATGIGSMPGGDAREAAKTVTGSLEDFPHLPEL
                     PARGPGADMIGRTLGLLVELYAHVEPSGWRISDRPGRDTRRARSWLGEDLDALEEFTQG
                     YEGPLKVSAVGPWTLAAALELRNGEAALGDPGACRDLTESLAEGLRGHLAEVRRRVPGA
                     ELVLQLDEPSLTAVLQGRVRTASGYRTHRAVDRAVVEGALRDLVGAADGAPVVVHSCAP
                     EVPFALLRRAGATGVSFDAALLTEREDEALGEAVEGGTALFAGVVPGVDGRLSDPAGSV
                     MGVRTLWRRLGLAPGLLAESVVVTPSCGLAGASPAYARAALAHCVRAARSLADNPE"
     gene            17782..19998
                     /gene="ligA"
                     /locus_tag="HRD51_RS28245"
                     /old_locus_tag="HRD51_27895"
     CDS             17782..19998
                     /EC_number="6.5.1.2"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003911 - DNA ligase (NAD+) activity
                     [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /gene="ligA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602953.1"
                     /locus_tag="HRD51_RS28245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_27895"
                     /product="NAD-dependent DNA ligase LigA"
                     /protein_id="WP_205366770.1"
                     /transl_table=11
                     /translation="MAGEQHAAATKVPAAAREKHAQLAEQIEEHRFRYYVKDAPVVSDA
                     EFDKLLRALEALEETHPELRTPDSPTQKVAGSYATEFTEVAHRERMLSLDNAFDDEELS
                     AWAERIATELGGDARGAGYHFLCELKVDGLAVNLTYEHGRLTRAATRGDGRTGEDITPN
                     VRTIAEIPHRLQGDRVPELVEIRGEVYFPMEKFLELNERLVADGKPPFANPRNAAAGSL
                     RQKDPKVTATRPLHMVVHGLGARDGLEIDRLSEAYDLLKEWGLPTATHNRVVDSLAAVR
                     EFIAHYGDPETRSTAVEHEIDGVVVKLDEIRLQGRLGATSRAPRWAIAWKYPPEEVNTK
                     LVDIRVGVGRTGRVTPYAVVEPVTVAGSEVEFATLHNQDVVKAKGVLIGDTIVIRKAGD
                     VIPEILGPVVDLRDGTEREFVMPAECPECGSALQPAKEGDIDLRCPNARSCPAQIRERL
                     FYLAGRKCLDIENFGYVAATALSQPLEPAEPPLTDEGGLFDLSVEELLPIKSHVLDPDT
                     GLPKRDPKTGEEKVVTFFANQKGEPKKNTLAMLENIQAAKERPLARILTGLSIRHVGPV
                     AAQALAREFRSIDRIREASEEELAAVEGVGGTIAASLKQWFAVDWHQEIIERWRAAGVR
                     MEEEQSGETGPRPLEGVTVVVTGTLQSHTRDGAKEALQALGAKVTGSVSKKTGFVVVGD
                     NPGSKYDKAMQLKVPVLDDDGFAVLLEQGPEAARAVAVTPPEEE"
     misc_feature    complement(17806..17819)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.82"
                     /tool="antismash"
ORIGIN
        1 tgcaccgggc ctcccgtcag cagcgcagca aggtgcggat gtccggcgaa atctggctgg
       61 acggcaagga gttggtcgcc gccgacccgg acgaggtgcg ccggctgcgc ggccgcgaga
      121 tggcgatgat cttccaggat ccgctgtccg cgctgcaccc cttctacacg gtcggccagc
      181 agatcgtgga ggcgtaccgg gtccaccacg acgtcgacaa gaagaccgcc cgcaagcgcg
      241 ccgtggagat gctcgaccgg gtcggcatcc cgcagccgga caagcgggtg gacgaccatc
      301 cgcaccagtt ctccggcggc atgcgccagc gcgccatgat cgccatggcg ctggtcaaca
      361 accccgagct gctgatcgcg gacgagccga ccaccgccct ggacgtcacc gtccaggcgc
      421 agatcctgga cctgatccgc gatctgcaga aggagttcgg ctcggcggtc atcatcatca
      481 cccacgacct gggcgtggtc gccgagctcg ccgacgacct gctggtgatg tacggcggcc
      541 ggtgcgtgga gcggggcccc tcgggcgagg tgttcgccac cccgcagcac ccctacacct
      601 ggggcctgct cggctccatg ccgcggatcg accgtgacca gaccgaccgg ctcatcccgg
      661 tcaagggctc gccgcccagc ctgatcaacg tgccgtccgg ctgtgccttc aacccccgtt
      721 gcccgtacgc ggacgtcccc aaggacaacg tcacccgcac ggtgcgcccc gaactgcagc
      781 aggtcgacgg ccggcacttc tccgcctgcc acctgccgcg ggaggagcgg gagcgtatct
      841 ggaccgaaga gattgcgccg aagctgtgac cgagaagact gagaagcctg aggcggccgc
      901 gaagcccgag caggccgaga acgccgaaca ggccgagcgg gtcgagagcg cggagcagac
      961 cgagaaggcc gagccggccg ggcgcgccgc ccaggacgag ccgctgctgc gggtccgcgg
     1021 cctggtccgg cacttcccga tcaccaaggg cctgctcaag cgcaaggtcg gcgccgtcca
     1081 ggcggtcgac gggatcgact tcgacgtctt ccccggggag acgctgggcg tcgtcggcga
     1141 gtccggctgc ggcaagtcga cgatgggccg gctgatcacc cggctcgacg aaccgaccgg
     1201 cggctcggtc gagttcgagg gccaggacat cacccacctg tccccgggcc ggctgcgccc
     1261 gctgcgccgc gacatccaga tgatcttcca ggacccgtac ggttcgctga acccgcggca
     1321 caccatcggc gggatcgtct ccaccccctt ccggctccag ggcgtcgagc ccgagggcgg
     1381 ggtcaagaag gaggtgcagc ggctgctgga gctggtgggc ctgagcccgg agcactacaa
     1441 ccgctatccg cacgagttct ccggcggtca gcgccagcgc atcggtatcg cccgggcgct
     1501 ggccctcaag ccgaagctgg tggtcgccga cgagccggtc tccgccctcg acgtctccat
     1561 ccaggcccag gtcgtcaacc tcatggacga cctccaggag gagctgggcc tgacctacgt
     1621 gatcatcgcg cacgacctct cggtcatccg gcacgtctcg gaccggatcg cggtgatgta
     1681 cctcggcaag atcgtcgaac tggccgaccg ggactcgctc tacgcctcgc cccggcaccc
     1741 gtacaccaag gcgctgctct cggccgtgcc ggtgcccgac cccaagcggc gcacccagcg
     1801 cggccggatc ctgctcaagg gcgacgtccc ctcgccgatc aacccgccgt ccggctgccg
     1861 gttccgcacc cgctgttgga aggcgaccga ggagtgcacc accaccgagc cgccgctgat
     1921 ccagttgcgg accgggcacc aggtggcctg ccaccacccc gagggcgagt cggacaactc
     1981 cggtacggcg accgaaagtt cggacggtaa ggcatcaacc gggcagtaac gcctgacgac
     2041 ttggcaaagt cgctggtgaa gacggacggg agagtgcaga gtcggcgcgg ttgttcatca
     2101 cgcatccgcg tactcgaagg gacggctcat ggcactctcc cgttctgcgc gtcgctcctc
     2161 ccgttggctc gccctggcca ccgcggtggc ctcggccgcc accatcgccg cggcccccgc
     2221 ggccacaccg ggcgcccccg gcatcggtga cccctacttc cccgggttgg gcaacggggg
     2281 ctaccggccc ctccactacg acctcggcgt cagctaccac cccgactccg gccggctgga
     2341 cggcaggacc acgctgaccg cccgggccac ccaggacctc tcctcgttcg acctggacct
     2401 ccagaagctg accgtcgacc aggtccgggt cgacggccgc cccgcccgct tctccagaac
     2461 cggcgacgaa ctcgtcatcc ggcccggccg cccgctcgcc cgcggcgagc gcttcgcggt
     2521 caccgtcgtc taccacggcg tcccccagcc gctcagtggc ccgatcgtct tcggttcgca
     2581 gtacggctgg atgaagacca aggacggcgt cttcgtggcc tgcgagccca acgccgcctc
     2641 gacgtggttc ccctccagcg accacccgga cgagaaggcc acctacgaca tccgcatcga
     2701 cgcccccaag ggcctgaccg gggtctccaa cgggcggctg gtgggctccg gcgagcacgg
     2761 cgaccgggcg tggttccact ggcgcgagag ccgcccgatg gcgccgtacc tggccaccgc
     2821 caccatcggg aagttcgacg tgcgcaccgg caccaccccc ggcggcaccc cgatctacgt
     2881 cgccaccgac ccgaccctgc cgaccggcaa ggtcgacgtc tacggcgtca ccgcggcggc
     2941 caccgactac tggtcgaagg tgttcgggcc gtaccccttc gaggagaccg gcgcgatcgt
     3001 ggacgacatg ccgcaggccg gcttctccct ggaggtgcag tccaagccgg cctactccgc
     3061 cgtccgcagc gagagcacca tcgtccacga gctggcccac cagtggttcg gcgactcggt
     3121 ctcggtccgg cagtggaagg acatctggct caacgagggc ttcgccacct acgcccagtg
     3181 gctgtgggcc gagcacaagg gcaccgccac cgcccacgac gccttccgca aggcgtacca
     3241 ggggataccc gccgacgacg ccttctggaa gatcaaggtc tccgacccgc agcgggacac
     3301 catgttctcc gacgcggtct acgagcgcgg cgcgatgacc ctccaggcgc tccgcgaacg
     3361 catcggcgac cgggcgttct tccgcctgct gccggcctgg accgcccggc accgctacgg
     3421 caacgcggac accgccgact tcatcgcgct ggccgagaag atctccgggc agcggctggg
     3481 cgacctcttc cacacctggc tggacaccca gagccgccca gcgctgtcgg agcggtgacc
     3541 ggctagccgg cgtcctcgcg cccccggccg cgcagctgct gcggccgggg caggtgcagc
     3601 cccagataga gcgcgcccat ccggagtgcg aacaccaacc ccgccgagac caccgcggcg
     3661 gggttggccc cggccccgag gcggtccatc aggaggtagc agcaggcgcc ggccagcgcc
     3721 gcgatggcgt agacgtcctc gcgcagcagc agcggcggga actccccgca cagcacgtcg
     3781 cggaggacct cgccggccac gccggtcagc accgccagga tgatcaccgc gagcggggtg
     3841 gcgcccgccg agatcgccgc ccgggccccg atcaccgtga ccacggacag cccgatcgcg
     3901 tccaccacca gcagcgactt ccgcggcagt gaccagaaac gcagatagac gatggtgccc
     3961 acgccgacgc agatgatcac cgtcagcagt acccagtcgt gcgtccagta cagcggccgc
     4021 cggtccagga tcagatcgcg cagcgtgccg ccggagatgg acgcggcgaa ggcgaggacc
     4081 agaccgccga acgggtccat gttggcgcgg taggccgcca gcacgccgct cgcggcgaag
     4141 gccgcgacgc cgatcaggta gagcacatga agcatgcggt catgatgaca gccgcggaag
     4201 cggcggctcc ggccgcgttc cccgtccgcc gccgttccgt tccttgaaat tgacactacc
     4261 ggtcggtaat gaagccgtgt agcgtgccgg catggcatcg gtgaccgtag gaaacagcga
     4321 gttcgaccgc gacaccgcgg tcacccggag cgccccgggc gtctacgacg cgcacctctc
     4381 cgagggctgg acgatcatca acgccgtcaa cggcggctac ctcctcgccc tcatgggccg
     4441 cgccctgggc gacgccctgc cgcacccgga cccgctcacc gtcaccgcgc actacctgac
     4501 cgcctcggtg cccggccccg ccgtcgtccg caccgaggtg atccgcaccg gccgcaccct
     4561 gtccaccggc accgccaccc tcgtccagct cgccgacgac ggcagcgagg tcgagcggat
     4621 gcgggtgctg gccacctacg gcgacctcgc cacccttccc gacgacgtcc gcaccaccgc
     4681 caagcccccg gccatcccgc cctacgagca ctgcctgggc acttccccca cgcctgaacg
     4741 gcgcgggggg acccccatcg cccccgacgg ccggccggcg atccccggca gcaccgcgat
     4801 cgccggacgc ctggacctcc ggctcgaccc ggcgaccgcg ggctgggcgg tgggcgcccc
     4861 gtccggcaag ggcgagatgc gcggctggtt cggcctggcc gacggccgcg accccgaccc
     4921 gctctccctc ctgctgaccg tcgacgcgct gccgcccacc gccttcgagc tgggcctgcg
     4981 tggctgggtc cccaccgtcg agctgacctg ccacgtccgc caccgcccgg cccccggccc
     5041 gctgcgggtc gccatcacca cccgcaatct ggccggcggc ttcctggagg aggacgccga
     5101 ggtctgggac tccgaggacc gcctggtcgc ccagtcccgc cagctggccc gcacgatcct
     5161 ggtgcggtag ccgcgccgcc cggcgaactc cctcaccgtc gggggtggtt ggcccggcgc
     5221 ctgctccgca tgtcgcgggc gtggaccgtg cggcccgcac ggccgacggg gcgggccacc
     5281 gcggagccgc cgcggcccga tcaaggcgtg cgccctgcgg aatgcgcccc cgcgcggggt
     5341 acgcgccccg gggtggctcg tagaatcagc gcaccatggt ttacctcgac cacgccgcca
     5401 ccaccccgat gctcccggag gcggtgcagg cgatgaccgc ccagctgacc gtcacgggca
     5461 acgcgtcctc cctgcacgcc gccggccggc gggcccggcg taccgtcgag gaggcgcggg
     5521 agtcgctcgc cgcctccttg ggcgcgcggc ccagcgaagt cgtcttcacg gcgggcggta
     5581 cggaggccga caacctcgcg gtgaaggggc tgtactggtc ccgccgggcc gccgacccgg
     5641 cccgcacccg gatcctcgtc agccccgtcg agcaccacgc cgtgctggac gccgtcgagt
     5701 ggctcgccga gcaggagggc gccaccgtcg actggctgcc ggtcgaccag tacggccggg
     5761 tgcacgccga ggcgctgcgc gaggcgatcg cccgcaaccc cgccgacgtc gcgctggcca
     5821 ccgtgatgtg ggccaacaac gagatcggca ccgtccagcc gatccgcgaa ctggccgagg
     5881 tggcacggga gttcgcgatc ccgctgcacg ccgacgcggt ccaggcggtc ggccagctgg
     5941 acgtcgactt caccgcctcc ggactggccg cgatgaccgt ctccggccac aagatcggtg
     6001 gcccgtacgg catcggcgcg ctgctgctgg gccgggagca cgcccccgtg cccgtgctgc
     6061 acggcggcgg ccaggaacgc cacgtccgct ccggcaccct cgacaccccc gcgatcgccg
     6121 cgttcgccgc ggccggccgg cacgccgtgg cgcaccggga ggagttcgcc cgcgagatcg
     6181 gcacgctccg cgacgacctg atcaaggcgg tgaaggcggc cgcccccgac gccgtcctgg
     6241 gcggcgaccc ggacccggcc ggccgcctcc cggccaacgc ccacttcacg ttccccggct
     6301 gcgagggcga ctccctgctg ctcctcctgg acgcccaggg catcgcctgc tccaccggct
     6361 ccgcctgcac cgccggcgtc gcccagccca gccacgtcct gctggccacc gggatgtccc
     6421 aggacctcgc ccgaggcacc ctgcgcttct cgctcggcca cacctccacc gcgcaggacg
     6481 tggcggccct cgcggaggtc atcggcccgg tggtggaacg cgcccggggc gcggggctga
     6541 gctaggtcgt gcccggccgc gtccgggccg cggggcggcg cagctccgcc cggaccagcg
     6601 tcagatagcg gtcccagtcc cagtgcggcc cggggtcggt gtggtccgtc ccagggacct
     6661 cgatgtgacc gacgacgtgc tcccggtcgg ccgggaagtc ataccggtgg cagatgccgg
     6721 ccgtcagccg ggccgacgcc gcgtacatgt ccggggtgaa ggactccggc cggtccacga
     6781 atccggcgtg ctcgatgccc acgctgcgct cgttgtagcc gcggttgccg gcgtggaacg
     6841 ccacgtccag ttcgcggacg gtctgcgcga tgtgcccgtc cccgcggacg acgtagtgcg
     6901 ccgacgcctc gtggaagggg tcccggaaga ccttcagcgc ggtggcgaag ctgccctgga
     6961 cgacgtggat caccacgcgg tcgacggtgt agtcgtcggg gcggttggcc tgtcggtagt
     7021 tcgccgggga ggcggccgac cactgcgcac cggcgaagtc gacctcgccc tccttccggg
     7081 ggcggctgtt ccccggcagc tgcccccacc agtacgccag ctcctcgcgg gccgcgaccg
     7141 ccgccgcccc cgcggccacc gcggcaccgc cgccgagcag cagcacccgg cgccgggtga
     7201 gccgccgccc ggcgcgcttc ccgtcgtccg ccgccccgtc cgccgtgccc ggggacgtcc
     7261 gctccgcgtc ccgcgcgtcg tccgccgccg tgtcctccac gccctgcacg ccctccacct
     7321 ctcccacgcc ctccacaacg ctttccgggc gccgcccggt tccgtctact ctggaggggc
     7381 tatgactgat gccgccgccc cccgccgcct ccgcgtcctc gccgccatgt ccggcggggt
     7441 cgattccgcc gtcgccgcgg cccgcgccgc cgaggcgggc cacgacgtca ccggcgtcca
     7501 cctcgcgctg tccgagaacc ccacgtcgtt ccgcaccggg gcccgcggct gctgcacgat
     7561 cgaggactcg cacgacgccc gtcgtgccgc cgacgtcatc ggcatcccct tctacgtctg
     7621 ggacctcgcc gaacgcttcc gcgaggacgt cgtcgaggac ttcatcgccg agtacgaggc
     7681 cggccgcacc ccgaacccgt gcctgcgctg caacgagaag atcaagttcg ccgccctcct
     7741 ggacaaggcg ctcgccctcg gcttcgacgc ggtgtgcacc ggccactacg cccaggtggt
     7801 cctccgcgag gacggctccc gcgagctgca ccgtgccacc gacatggcca aggaccagtc
     7861 ctacgtcctc ggcgtgctcg acgaccgcca gctggcgcac gccatgttcc cgctcggcga
     7921 cacccccacc accaagaccg agatccgcga agaggccgcc cggcgcggcc tgttcgtcgc
     7981 caagaagccc gacagccacg acatctgctt catcgccgac ggcgacaccc agggcttcct
     8041 cgccaagcga ctgggcagcg ccgagggcga catcgtcgac gagtccggca cgaagctcgg
     8101 cacccacgag ggcgcctacg gcttcacgat cggccagcgc aaggggctgc gcatcggcac
     8161 cccggccgcg gacggcaagc cgcgctacgt cctggacatc tccccggtga acaacaccgt
     8221 caccgtcggc cccgtcgagt ccctggacgt gaccgcgctc acggccatca agccgcgctg
     8281 gtgcggccgc ccgccggccg acggcccggc cgtctacacc gcccaactgc gcgcccacgg
     8341 cggcgagacc gaggtcaccg ccgaggtggt cggcgaggag ctgcgggtct ccttcaccga
     8401 gcccgtgcgg ggcgtcgccc cggggcaggc cgtggtcctg tacgacggga cccgcgtggt
     8461 gggttcggcc accatcgcca ccacccgccg ggccgcgtcg gtggcctgag ccgggccgac
     8521 tcggccggac cgtccgcgtc atgccggacg cggctgagac atctgacaca ccagaggtgt
     8581 ctgaggctcg tgttgcgcgt gaggctgtcc gaaagcgagc gcaccaaacc gcgtcacaac
     8641 gacccgtccg ggccgggccc gtcccttcag gggcaggccc ggcccggttt ttgccacccc
     8701 gaaaaccggt gggaaggttt ccgattttgc tgcgtcggtg gcgtgaattc ggtactgcgg
     8761 agcgcttaaa ttcacgtcgc tgtgacgaac gctctcccaa ccccccttgt ccggccagat
     8821 cgtgagctgg tacacctagt ccgaaaaatt gttccgccga actgaatcga actcagtcac
     8881 cggtcagccg ggcgggtcgg tcgtgaatcc gaccccaggg caatcgatgc gctattgcct
     8941 gccgtcggac ccggccgtgc ccgtggatcc gtcccgacgg gcgggaaccg gtgaggcgcc
     9001 acccatcgga ttcgccgtac cgcggcgggt gtgaggtgcg cccaaaaaag aaggggattg
     9061 atgttggctc acagttcatc tgaatcaccg ccggaatcct tgccggacgc gtggacggtc
     9121 ctcaaaaccc gtaccgccgt ccgcaattat gcgaaggagc cggtcgacga cgcgctgatc
     9181 gagcagctgt tggaggccat gctcgccgcg ccgaccgcct ccaaccggca ggcgtggtcg
     9241 ttcatggtgg tgcgcaggcc cgccgcggtc cgccggctgc gcgcgttctc gcccggggtg
     9301 ctggggaccc ccgcgttctt cgtcgtggcc tgcgtcgacc gcagcctgac cgacaacctc
     9361 tccccgaagc tctcgcagaa gatctacgac accagcaagc tctgtgtcgc catggcggtg
     9421 gagaacctgc tgctcgcggc gcacgcggcc ggcctgggcg gatgcccggt gggcagtttc
     9481 aggtccgaga tcgtcaaaag catgctcggt atcccggaac acatcgagcc gatgctcgtg
     9541 gtcccgatcg gccgtcccgc gacggacctc gtcccctccc agcgccgcgc caagaatgag
     9601 gtcgtcaact atgaatcctg gggaaaccgt gctgccgccc caactgcgtg aggagatcgc
     9661 gctcctcgcc gtttatctgc tcagcagcgg tcgcggactc ctggaggagc cggccgacta
     9721 cggaatttac cgctgtaccg acggggcccg tcgggcgctc cagctcctcg acgaacacgg
     9781 cgggagcacg gcacggctga ccgctgtgcg cgagcgtctc gacgaggtca tgttcgcgcc
     9841 gatgggcgag gaccgggaca tgggcgagat tctggacgac ctgtgtcgcc aaatggcaga
     9901 cgctcttccg gaaatagaaa ccccctgacg gctgtccggg gcaaccccaa aaggacttct
     9961 tagcatgctt gcaggcttag ttcccgcgcc ggaccacgga atgcgggaag aaatacttgg
    10021 cgaccgcagc cgaatgatcc ggcaacgcgg tgagcacgcc ctcatcggaa tcagtgcggg
    10081 caacagttat ttcagccaga agaacaccat catgctgctg caatgggccg ggcagcgttt
    10141 cgagcgcacc gatgtcgtct atgtcgacac ccacatcgac gagatgctga tcgccgacgg
    10201 ccgcagcgcg caggaggccg agcggtcggt caaacgcacg ctcaaggatc tgcggcgcag
    10261 actccggcgc tcgctggaga gcgtgggcga ccacgccgag cggttccgtg tccggtccct
    10321 gtccgagctc caggagaccc ctgagtaccg ggccgtacgc gagcgcaccg accgggcctt
    10381 cgaggaggac gccgaattcg ccaccgcctg cgaggacatg gtgcgggccg tggtgatgaa
    10441 ccggcccggt gacagcgtcg gcctctccgc ggaacacctg cgggccggtc tgaactacgt
    10501 gctggccgag gcaccgctct tcgcggactc gcccggcgtc ttctccgtcc cctcctcggt
    10561 gctctgctac cacgtcgaca ccccgatcac gacgttcctg tcccggcgcg agaccggctt
    10621 ccgggcggcc gaggggcagg cgtacgtcgt cgtcagaccg caggagctgg ccgacgcggc
    10681 ctagggcccg acggatcggg gtcggacaga ccctggtcgg ggcgtccgcg ggcggatctc
    10741 cctccgccgc ccgctcccgg tgccggcgcc gggaatgaca aatgtcatgg ggaggacagg
    10801 acacttgctc ctgatgcgga acggggtccc tcggcgaaga tgacggcgta ggaagacagc
    10861 acacgtcgca cgccggggga cccgtcatga ctcaagccgc caccgccacc gccaccacga
    10921 gccagggcag ggcgctcctg cagagcctga cgccgctgct cgtggacgcc gcgatcccgc
    10981 tcggctcgta cttcctcctc gccgagggct tcggcatgag cacggtcgcc gcgctggcct
    11041 ggagcagcgt ggtcccggcg ctgcgcacga tctggggcct ggcccgggag cggacggtca
    11101 acggcctcgc gctgctgatc ctcgtcgtca acgtggtggg gctggcgacg agcaccctga
    11161 ccggcgatgc ccggctgatg atggccaagg acagcggcgt cagcagcgtc gtcgggatcg
    11221 cgatcctgct ctcggtgcgc ggccggcggc cgctgatgac cgccgggctc cggccctggg
    11281 tgaccaaggg cggccccgag gggaacgccg catgggaccg gctgtgggcg ggcagcgcac
    11341 ggttccggca actggagcgg cggttctcca cggtgtgggg gagcgccctg ctgatcgagt
    11401 gcgtggtcaa ggccgtcggt gcgtacgtcc tgccggtgca caccatggtg tggctgggca
    11461 cggtgctgac ggtggtggcg atcctgctgg ccatggtggt cgcgggcggc agctgcgccg
    11521 agccgatgga gcagatggtc aaggccgagg tccgggccgc aggcgaggcc gccgcggcgg
    11581 ggaacgccga gccggcgccg gccgccgcgg cctgagacca cccggcgggg gagttgggga
    11641 catcgcgtac aggattggcg cgtcgagcac ccccgccctc gataggccgg tccccggcgc
    11701 atatcgtcgg cgatgcgacg ggacatcgga gccccgcgtc gacggttcaa cggcgatccg
    11761 gacggcacgc ggctttcgtc ggccacgaag ggaacgggag tcatgtcgac tgttcacact
    11821 ggggtcacgc agagcggtct caccgccgag ctggcttccc tgcacgccga gctcgtccgt
    11881 cggaatcccg gtgaagcgga gttccaccag gcggccctgg aggtcctcga aacgctggca
    11941 ccggtgctca ccgcccggcc ggagttcgcg gacgccaagg ttctggagcg gatggtagag
    12001 ccggagcggc agatcatgtt ccgcgtgccc tggcaggacg actccggcaa gatccgggtc
    12061 aaccgcggct tccgggtgga gttcaacagc gcgctcggcc cgtacaaggg cggcctgcgg
    12121 ttccatgcgt ccgtcaacct cggcatcgtg aagttcctcg gcttcgagca gatcttcaag
    12181 aacgccctga ccgggctgaa catcggcggc ggcaagggcg gcagcgactt cgacccgcac
    12241 ggcaggtcgg acgccgaggt gatgcgcttc tgccagtcct tcatgaccga gctgcaccgt
    12301 cacctgggcg agcacaccga cgtgccggcc ggcgacatcg gcgtcggcgg tcgggagatc
    12361 gggtacctct tcggccagta ccggcggatc accaaccgct gggaggccgg cgtcctgacc
    12421 ggcaagggcc tggcgtgggg cggctccaag gcccgtacgg aggccaccgg ttatggcaat
    12481 gtgctgttca ccgaggagat gctcaagcag cgcggcgagg agctggacgg ccagcaggtg
    12541 gtggtctccg ggtccggcaa cgtcgccatc tacaccatcg agaaggccca ggcgctcggc
    12601 gccaacgtcc tgaccgtctc ggactccggc ggctacgtcg tcgacgagaa gggcatcgac
    12661 ctggcgctgc tcaagcagat caaggaggtc gagcgcggcc gggtcggcga ctacgcgcag
    12721 cggcgcggca gttcggcgaa gtacgtcgcc ggcgggagcg tgtgggacgt cgcctgtgac
    12781 gtggcgctgc cgtcggccac ccagaacgag ctcgacgcgg acgccgcccg gatcctggtc
    12841 cgcaacggcg tcaaggcggt ctccgagggc gccaacatgc ccaccacccc acaggcggtg
    12901 gcgctgctga aggaggccgg cgtggccttc ggcccgggca aggccgccaa cgccggcggg
    12961 gtggcgacca gcgcgctgga gatgcggcag aactccgccc gcgaggcgtg gccgttcgag
    13021 cgcgcggagg gcgaactcgc cgccatcatg cgggggatcc acgacacctg ccaccagacc
    13081 gccgagcgct tcggtcggcc cggtgactac gtggccggcg ccaacatcgc cggcttcgag
    13141 cgggtcgcgg acgcgatgct ggaccagggc ctgatctaga cgccccgccg ggcccggccg
    13201 cggaaccgct ccgcggccgg gcccggtgtc cttccccgcg ccccgtgggg cgtccgccgc
    13261 gtgcccgtag gctgaacggc atgaatatct gcgtcttctg ttccgccgcc gacctcgatg
    13321 accgctatgt ggtgcccgcc cgtgaattcg ccgaatcgat cggtcggcgc ggacatgccc
    13381 tggtctgggg cggttcggac accgggctga tgaaggtcat ggcggacggc gtccaggagg
    13441 ccggcgggaa actgctcggg gtctccgtgg agttcctggc ggacaagacg cgcgccaacg
    13501 cggacgagat ggtcgtcacc aaggacctcg ccgagcgcaa ggcgcagttg ctggcgcggg
    13561 ccgacgccat cgtcgtcatg gtgggcggca ccggcacgct ggacgaggcg accgagatcc
    13621 tggagctgcg caagcacggg atgcacagca agccggtggt gctgctgaac accgccggtt
    13681 tctacgacgg gctcaaggcc cagttcgagc ggatggaggc ggagggcttc ctgcccgttc
    13741 ccctctccga gctggtgttc ttcgccgagg acggcgcggg cgcgctggcc cacctggagg
    13801 cgtgggaggc cgccgcgggc tgacccgccc ccggggggca cgccgtagga tcgcacccat
    13861 gggtacgcac ttgatcacgg gcgccggatc gggcatcgga gcggcggtag cgcggcggct
    13921 cgccgagcgc ggtgaggagc tgtggctgct ggcgcgcgac gtcggccggg ccaaggagtt
    13981 ggcggaacgg ttccccgggg cgcacaccct cgtcggtgac ctcgccaccc ccgagaagct
    14041 cgactgggcg ctcgggcacc aacggctgcc ggagcggctc gactcgatcc agcacatcgc
    14101 gggcgtcatc gagctgggtg cggtcggcga cctgccggcc aaggcgtggc agcggcagct
    14161 ggcggtcaac ctcgtcgcgc ccgccgagat cacccggctg ctgctgccgc tggtccggat
    14221 cgccaagggt gacgtggtct tcgtcaactc cggtgccggg ctcaccgcga accccaactg
    14281 gggcgggtac gccgcgagca agcacggcct gaaggcgctg gccgacgcgc tgcgcgcgga
    14341 ggagcacgac aacggcgtcc gggtcacctc gatctacccg gggcgcaccg ccacgcccat
    14401 gcaggagagc acccaccgcc aggagggcaa ggcgtacgac gcgtcccggt ggatcgaccc
    14461 ggagtcggtg gccacggcca tcctcaccgc gatcgacctg ccgcgggacg cggagatcaa
    14521 ggacctggtg gtccggccgg gccgctgacc accggcggcc ccggggctcc cggggccgcc
    14581 cggcggtccg cccgccccga ccggacctgg cccccgtgcc tcgcgcgggg gcgacgtacg
    14641 cttcaggggt gaccacgtca agggcgacca ccgaagcgaa gaccaccgcc gcggcggagt
    14701 gcggattccg ggagatcagg gggctggtca ccgagctgag ccgccgcctg gacgcccacc
    14761 agcgcagccg gatcgcggag ctggacctga cgccgacgca ggcgaaggcg ctggaggagc
    14821 tgggcgagcc caagaccgcg cgggagttgg ccgcggtgct gtgctgcgag ccgccgaacg
    14881 tcacctatgt catctccaag ctggagaagc aggggatggt ggtccgccgc ccgcaccccg
    14941 cggacgggcg cgccaagcag ctggtgctga ccgaggccgg tcgggagctg cggctggacc
    15001 tgctgcggcg gatgggcacg gagtccccgc tggaccacct ctcccacgag gagcgcagcg
    15061 cgctccgcga cgaactcctc agagcgctgg gccgcgctac ggacgcggcc tagagcgcgt
    15121 ccgccgtcct gccgaaggcc cccggggcat cgtcccgggg gccttcggtg tttcttggta
    15181 tcgcttcgat aaagttatag ctgtaatcat cgcgcgcggt ggatagatac agctataact
    15241 aaatccatga tcactgagaa cgcggcgccg cgcgcgacgg cgagcacccc cacccgtccc
    15301 gcacccgccg gcggagccgc ccaactcgtc gtcctggccc tggggttcgt gatggcgagc
    15361 ctggacaccg gcatcatgaa cgtcgccgcg cacgacctcc gggcccggct cgggctgacc
    15421 atgtccggcc tcacctgggt cgtcgacggc tacgtcctcg ccttcgccgc gctgctgctg
    15481 ctcgccggct cgctcgccaa gcggttcggc gcccggcgga tctacctcgt cgggctggcc
    15541 gtcttcaccg ccgcgtccct gctgggcgcc gcggcgccgg gcggcggcgc cctggtggcg
    15601 gcccgcttcg cccaaggggc gggcgccgcg ctcttcatgc ccagctcgct gtcgctgctg
    15661 atgaacgcct tcccggagcc ggcccgccgg gcgaaggtgc tcggcatctg gtccgcgatc
    15721 gtctccacct ccgtcggcct ggcaccgacc gtcggcggcc tgctcgtcgg caccctcggc
    15781 tggcgcagca tcttcctggt caacctcccc atcgggatcg ccggactgct gctcacccgc
    15841 cgggtgatcg ccgcggtccc gggcaccggc gccccgctcg gcggcaccgg ccacgtcctc
    15901 ggcctgctcg ccctcggctc gctcagctac gccctcatcg aggggcccgc cgccggctgg
    15961 gccgcccccg gagtcctggc ggcgttcgcg gtgaccgtgc tcgccgccgc cggcttcgtg
    16021 gtccgggaac gcaccgcccg caccccggtc ctgcccgtca ccctcttcgc cgacagccgc
    16081 ttctccgccg ccaacgcggt cggcttcctc ttcaacttcg ccttctacgg ggcgctgttc
    16141 gtcctcgggc tcttcctcca gacgggccgc ggcgccgacg cggtgaccgc gggtctgcag
    16201 atgctcccgg cggtcctcgt catcccgatc ggcaacgtgc tctacacgcg gatcgcgccg
    16261 cgcaccggca accgggccgc gctcgccgtc tccctggccc tctccgccgc cggctacctc
    16321 ctgctcttcc tggtcctctc gccgaccctg ccgtacgggg tgatcgcggt ggtgctggcc
    16381 gtcaccaaca tcggcagcgg gatcagctcc ccggcgatga ccggcgtcct gatggaggcc
    16441 gcgggccgcg agcacgccga catcggcagc gcgaccctca acgccaaccg tcaggtcggc
    16501 tcgctggtcg gcatcgccgg tatgggcgcg atcctgaccg gcgcgggcga tgcctaccag
    16561 ggcaccggat acgccttcgc gctgaccgcg gcggccctgg cggccgcggc ggtggtcggc
    16621 tggctgggcg tccgcggccg gcgctgaccc gggcgcggcg ttcgcgccgg gcgtacgggg
    16681 gcggggcggg cggggccggg gcggcccgcc cggcccgccg ccgcataccc ttccggggtg
    16741 agcgagaaca ccaggcacaa gtgggccgcg ggcgcggcga ccggcatcgg atcgatgccg
    16801 ggcggcgacg cgcgcgaagc ggcgaagacc gtcaccggat cgctggagga cttcccccat
    16861 ctgcccgagc tcccggcccg ggggcccggc gccgacatga tcggccgcac cctgggcctg
    16921 ctcgtcgagc tctacgccca tgtggagccc agcggctggc ggatcagcga ccggcccggc
    16981 cgcgacaccc gccgggcccg ctcctggctc ggtgaggacc tcgacgccct ggaggagttc
    17041 acccagggat acgagggacc gctgaaggtc tccgcggtcg gcccgtggac cctggccgcc
    17101 gccctggagc tgcgcaacgg cgaggcggcg ctcggcgacc ccggggcctg ccgggacctc
    17161 accgagtcgc tcgccgaggg gctgcgcggt catctcgccg aggtccgacg gcgggtgccg
    17221 ggcgccgaac tcgtcctcca gctcgacgag ccgtcgctga ccgcggtgct ccaggggcgg
    17281 gtgcggaccg cgagcggcta ccgcacccac cgggccgtgg accgcgcggt cgtcgagggc
    17341 gcgctgcgcg acctggtcgg ggcggcggac ggcgcaccgg tcgtggtcca ttcctgcgcg
    17401 cccgaggtgc cgttcgcact gctgcggcgg gccggtgcga ccggcgtctc gttcgatgcc
    17461 gcgctgctca ccgagcgtga ggacgaggcg ctcggcgagg cggtggaggg cggtaccgcg
    17521 ctgttcgcgg gcgtggtgcc gggcgtggac ggtcgattgt cagaccctgc cggtagcgtc
    17581 atgggtgtcc ggacgctgtg gcgcaggctg gggctggcac cgggacttct cgcggagtcc
    17641 gtggtggtca ccccgtcgtg cggtctggcg ggcgcctcgc ccgcctacgc ccgcgcggcg
    17701 ctcgcccact gcgtccgggc ggcgaggtca ctcgcagaca accctgagtg accgccctca
    17761 aggacacggg aggacaagac ggtggctggc gaacagcacg cggcggcaac caaggtgccc
    17821 gccgcggcac gggagaagca cgcgcagctc gctgagcaga tcgaggagca ccgcttccgg
    17881 tactacgtga aggacgcccc ggtcgtcagc gacgcggagt tcgacaagct gctgcgcgcc
    17941 ctggaggccc tggaggagac ccatcccgag ctgcgcaccc cggactcccc gacgcagaag
    18001 gtcgccggct cgtacgccac ggagttcacc gaggtcgcgc accgcgagcg gatgctctcg
    18061 ttggacaacg ccttcgacga cgaggaactg tcggcctggg ccgagcggat cgccaccgaa
    18121 ctgggcggcg acgccagggg cgccggctac cacttcctgt gcgagctgaa ggtcgacggc
    18181 ctcgcggtca acctcaccta cgagcacggc cgcctcaccc gcgccgccac ccggggcgac
    18241 ggccgcaccg gcgaggacat cacgcccaac gtccgcacca tcgccgagat cccgcaccgc
    18301 ctccagggcg accgggtccc cgagctggtc gagatccgcg gggaggtcta cttcccgatg
    18361 gagaagttcc tggagctcaa cgagcgcctg gtggccgacg gcaagccgcc gttcgccaac
    18421 ccccgtaacg ccgcggccgg ttcgctgcgc cagaaggacc ccaaggtcac cgccacccgc
    18481 ccgctgcaca tggtggtgca cggcctcggc gcccgcgacg gcctggagat cgaccgcctc
    18541 tccgaggcgt acgacctgct caaggagtgg ggcctgccca ccgccacgca caaccgcgtg
    18601 gtggactccc tcgccgcggt acgggagttc atcgcccact acggcgaccc cgagacccgc
    18661 agcacggccg tcgagcacga gatcgacggc gtcgtggtca agctcgacga gatccggctc
    18721 cagggccggc tgggcgccac ctcgcgggcg ccgcgctggg cgatcgcctg gaagtacccg
    18781 ccggaggagg tcaacaccaa gctggtggac atccgcgtcg gcgtcggccg caccggacgg
    18841 gtcacgccgt acgcggtcgt cgaaccggtc accgtggccg gttccgaggt ggagttcgcc
    18901 accctgcaca accaggacgt ggtcaaggcc aagggcgtcc tgatcggcga caccatcgtc
    18961 atccgcaagg cgggcgacgt cattccggag atcctcggcc cggtcgtcga cctgcgggac
    19021 ggcactgagc gggagttcgt gatgcccgcc gagtgccccg agtgcggctc ggcgctccag
    19081 cccgccaagg aaggcgacat cgacctgcgg tgtcccaacg cccggtcctg ccccgcccag
    19141 atccgcgagc ggctgttcta cctcgccggc cgcaagtgcc tggacatcga gaacttcggc
    19201 tatgtcgccg ccaccgccct cagtcagccg ctggagcccg ccgagccgcc gctgacggac
    19261 gagggcggcc tgttcgacct ctcggtcgag gagctgctgc ccatcaagtc ccatgtcctc
    19321 gacccggaca ccggcctgcc caagcgcgac ccgaagaccg gcgaggagaa ggtcgtcacc
    19381 ttcttcgcca accagaaggg cgagccgaag aagaacaccc tggccatgtt ggagaacatc
    19441 caggcggcca aggagcgccc gctggcccgg atcctcaccg ggctgtcgat ccgtcacgtg
    19501 ggcccggtgg cggcgcaggc gctggcccgg gagttccgct cgatcgaccg gatccgggag
    19561 gcgagcgagg aggaactggc ggccgtggag ggcgtcggcg gcaccatcgc ggcctcgctc
    19621 aagcagtggt tcgccgtgga ctggcaccag gagatcatcg agcgctggcg ggccgcgggc
    19681 gtccgtatgg aggaggagca gtcgggtgaa acgggcccgc gtcccctgga aggcgtcacc
    19741 gtcgtggtaa cgggcacact tcagtcacac accagagatg gcgcgaaaga agcgctacag
    19801 gctcttggtg cgaaggtgac cggatccgtt tccaagaaga ccggattcgt agtggtgggc
    19861 gacaaccccg gttcgaagta cgacaaagcc atgcagttga aggtccccgt gttggacgat
    19921 gacggcttcg ctgtgctgct ggagcagggt cccgaggcgg cacgagcggt agctgtcact
    19981 ccgcctgagg aggagtgaga tgtcacccca tcggcgcata ccagattgat ctgggaggcc
    20041 gggtcgcatt cgggcaaccg ctgcggatcg ctgcccgcag cggccttccg cgtcctactg
    20101 ttgacgtgtg cgcctgccgt ggcgcgggca cagccggctg tgagagggat cggaatgaaa
    20161 ccgaccgaca gcgccgctcc ggcgtcgcgg ctccgccggc ttgtggtgcc cgcgttgccc
    20221 gcggccatcg tcatggcggc gggcgtggtg ctcgccgccg gtgtgctcca ctcgctcggc
    20281 gacggtgagc cgttgttccc cgccggagcc atcggctggt cgctggcggt cctgaccggc
    20341 gtcatcgtcg gccatctggt cgccctcggc cgggaccggt ggtggggtgg caccggttcc
    20401 ggggcggccc tcgccctcgc cgtgctcctg ctctacggct gggtgccggc catcctggtc
    20461 agcctctccg tcgtggtcct ggtcggcgcc gcgcgacggc agcgctggcg acaggccgtg
    20521 gtccacgggg cagttgacct cctcggcatc ggcgccgcgg cgctcggcct ggtcgtctgc
    20581 ggggtgcagc ccagcgtccg ccggccctgg gcgcccgatg cctgggacct ctccgtcctg
    20641 cccgaggtcc tcgtgatggc ggggagctat ctcctcgtca gccg
//
