LOCUS       NZ_CP054019            22223 bp    DNA     linear   CON 28-JAN-2024
DEFINITION  Streptomyces sp. A1-5 chromosome.
ACCESSION   NZ_CP054019
VERSION     NZ_CP054019.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. A1-5
  ORGANISM  Streptomyces sp. A1-5
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9459690)
  AUTHORS   Dashti,Y., Sumang,F.A.M., de los Santos,E.L.C., Alcantara,E.P. and
            Challis,G.L.
  TITLE     Structural revision and biosynthesis of polyketides FXJ15321 and
            FXJ15322 from Streptomyces sp. A1-5
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9459690)
  AUTHORS   de los Santos,E.L.C.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAY-2020) Warwick Integrative Synthetic Biology
            Centre, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL,
            United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: JUN-2019
            Assembly Method                   :: Flye v. 2.4.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology :: Oxford Nanopore MiniION; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/28/2024 04:28:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,328
            CDSs (total)                      :: 8,230
            Genes (coding)                    :: 7,847
            CDSs (with protein)               :: 7,847
            Genes (RNA)                       :: 98
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 74
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 383
            CDSs (without protein)            :: 383
            Pseudo Genes (ambiguous residues) :: 0 of 383
            Pseudo Genes (frameshifted)       :: 156 of 383
            Pseudo Genes (incomplete)         :: 280 of 383
            Pseudo Genes (internal stop)      :: 26 of 383
            Pseudo Genes (multiple problems)  :: 73 of 383
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:08:01
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4967639
            Orig. end                         :: 4989862
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP054019.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Philippine National
            Collection of Microorganisms.
FEATURES             Location/Qualifiers
     region          1..22223
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="16"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22223
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22223
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12223](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12223
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            98..322
                     /locus_tag="HRD51_RS22230"
                     /old_locus_tag="HRD51_21915"
     CDS             98..322
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016572457.1"
                     /locus_tag="HRD51_RS22230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_21915"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_235093914.1"
                     /transl_table=11
                     /translation="MTERVIANAAALSGWRKSSYSDGEGAECMEVVDDHPHGIPVRDSK
                     APHGPAIVVPAGAWSAFVAAVKGEAFGGR"
     gene            complement(319..1542)
                     /gene="rocD"
                     /locus_tag="HRD51_RS22235"
                     /old_locus_tag="HRD51_21920"
     CDS             complement(319..1542)
                     /EC_number="2.6.1.13"
                     /GO_function="GO:0004587 - ornithine aminotransferase
                     activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (32-354). E-value: 2.7e-103.
                     Score: 337.5. Matches aSDomain:
                     nrpspksdomains_HRD51_RS22235_Aminotran_3.1"
                     /codon_start=1
                     /gene="rocD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019524735.1"
                     /locus_tag="HRD51_RS22235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_21920"
                     /product="ornithine--oxo-acid transaminase"
                     /protein_id="WP_235093915.1"
                     /sec_met_domain="Aminotran_3 (E-value: 3.4e-115, bitscore:
                     383.8, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTAPTDTRRSSASLIEAEAPVLAHNYHPLPVVISRAEGVWVEDV
                     EGRRYLDMLAGYSALNFGHRHPALIEAAHRQLDALTLTSRAFHHDRLGQFAGALAELTG
                     LDMVLPMNTGAEAVESGIKLARKWAYEVKGVPADQATIVVASGNFHGRTTTIISFSDDD
                     EARTGFGPYTPGFRTVPYNDLAALEAAIDDTTAAVLIEPIQGEAGVIIPDDGYLAGVRA
                     ATSRANCLFIADEIQSGLGRTGTTLAVEHEQVVPDVILLGKALGGGIVPVSAVVARREV
                     MSVLGPGQHGSTFGGNPLAAAVGTAVVDLLTTGEFQSHAADLGKVLHSGLTDLLGKGVT
                     AFRARGLWAGVDIDPALGTGRTISERLLSEGVLVKDTHGSTIRLAPPLTITENELTSAI
                     ATLGRVLA"
     aSDomain        complement(481..1446)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HRD51_RS22235_Aminotran_3.1"
                     /evalue="2.70E-103"
                     /label="HRD51_RS22235_Aminotran_3.1"
                     /locus_tag="HRD51_RS22235"
                     /protein_end="354"
                     /protein_start="32"
                     /score="337.5"
                     /tool="antismash"
                     /translation="VISRAEGVWVEDVEGRRYLDMLAGYSALNFGHRHPALIEAAHRQL
                     DALTLTSRAFHHDRLGQFAGALAELTGLDMVLPMNTGAEAVESGIKLARKWAYEVKGVP
                     ADQATIVVASGNFHGRTTTIISFSDDDEARTGFGPYTPGFRTVPYNDLAALEAAIDDTT
                     AAVLIEPIQGEAGVIIPDDGYLAGVRAATSRANCLFIADEIQSGLGRTGTTLAVEHEQV
                     VPDVILLGKALGGGIVPVSAVVARREVMSVLGPGQHGSTFGGNPLAAAVGTAVVDLLTT
                     GEFQSHAADLGKVLHSGLTDLLGKGVTAFRARGLWAGVDID"
     gene            complement(1539..2438)
                     /locus_tag="HRD51_RS22240"
                     /old_locus_tag="HRD51_21925"
     CDS             complement(1539..2438)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016572459.1"
                     /locus_tag="HRD51_RS22240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_21925"
                     /product="arginine deiminase-related protein"
                     /protein_id="WP_235093916.1"
                     /transl_table=11
                     /translation="MTHPGGALTRAPRTPRARRYLLCRPTHFAVEYAINPWMREDADVD
                     AALALRQWEDLVRAYRDHGHTVETVRPALGLPDMVFAANSAVVVGGRAFGSLFHAPQRR
                     PESHEYEIWFKGAGYDLHRPASPCEGEGDLVPVGRYLLAGTGFRTTRDAHAEVQEFFGR
                     PVISLQLTDPYFYHLDTALFVLDDGLAADGLPADGMGTGGNGAGGAALAYYPEAFSPGS
                     REVLRQLFPDAVLATRDDALAFGLNSVSDGRHVFVAPRATHLIDQLTARGYVPVPVDLS
                     EFHKAGGGIKCCTQELRP"
     gene            complement(2626..3219)
                     /locus_tag="HRD51_RS22245"
                     /old_locus_tag="HRD51_21930"
     CDS             complement(2626..3219)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004991130.1"
                     /locus_tag="HRD51_RS22245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_21930"
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_235093917.1"
                     /transl_table=11
                     /translation="MSTKSAPFDELDRKIVAALIENGRASFAEIGSAIGLSPTAVKRRV
                     DRLRETNVITGFSATVRPAALGWLTEAYVEVYCDSAAPPRRLAEVVRNHPEIAAAMTVT
                     GGADALLHVRATDVEHFEEVLERIRTEPFIRKTISYMVLSHLLPDSPEAGARRPSDDRS
                     AARPDDRAAHQAAGRAGDGARVHPQPLRRAANQR"
     gene            3487..4269
                     /locus_tag="HRD51_RS22250"
                     /old_locus_tag="HRD51_21935"
     CDS             3487..4269
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016572461.1"
                     /locus_tag="HRD51_RS22250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_21935"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_235093918.1"
                     /transl_table=11
                     /translation="MDADDGGDGHRGGAVGDGPTRADRARRVAHVLRGQVVRGAFAGGV
                     LPDERALVAEFGTSRNTVREALGLLRDEGLVERRRGVGTVVVGRTYEHPLGELSGLAEV
                     LQRHGTVVNEVRAARIVRAPGSVARRLELPEGSRAVYLERLRRVDGMPLSLDCTYLIPE
                     VGEPLLALGPERLENRDVFELIERAAGRPLGSAEVAVRAVVADPATCAVLGMAAGGAVL
                     AVDRLTRLADGRPADLEFIHLRGDRLTLRARLDRVREG"
     gene            4274..5809
                     /locus_tag="HRD51_RS22255"
                     /old_locus_tag="HRD51_21940"
     CDS             4274..5809
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019544674.1"
                     /locus_tag="HRD51_RS22255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_21940"
                     /product="MFS transporter"
                     /protein_id="WP_235093919.1"
                     /transl_table=11
                     /translation="MRSGRVPARAPVTCAMCLCVALVVGMVSAVNLAIPDLSAGPLHPS
                     AAAVVWVVDGYVVVFACLLVPAGALADRRGRKGTLLCGMAVFVLGSAVCAVAPHVEVLI
                     AGRMISGVGAAAVLPNTLALLVDGLSDGPRRRAIAVWAAMTGLAAVLGNVGGGAAIQYG
                     SWRALFVCVVPVAVGASVLVAVVAPVAGRHPGPVAPLAVALFTGGFLALLNGIVSGPGE
                     GWLGPWVLGSFGAAGLLLTGWARCELRSARPLLDPRVFARPAVRAGAVGMAVLFLGMFG
                     LFYLNGQYLQYAKGYGPFGAGVRLLPMAAALLAGPRCGLVLERRCGRRGTVATGMLVLA
                     GGLATVSAADAGTPYALYAVGAGLTALGCGTATPLLSHAMMSALPPEAAGVGSGLQSLT
                     RELGSALGIAVTGTLTAAVFTARLPAPLAGPGAPTTVAAAQAALGDLPDRGGELRTAVT
                     GAFTDGLHLATLVLAAGVAVAAGAVFRWMPREGEAEAGTARASAGGGPLTRTG"
     gene            complement(5937..7211)
                     /locus_tag="HRD51_RS22260"
                     /old_locus_tag="HRD51_21945"
     CDS             complement(5937..7211)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016578882.1"
                     /locus_tag="HRD51_RS22260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_21945"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_235096056.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 4.6e-38, bitscore:
                     130.2, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVLLPDGPVRDHAVLVEHGTFREVGPAARLLAAHRAGPAPIRLPG
                     HLLMPGFVDAHHHLTQGFGKAQSFGQPSEIFKTVWEPLEHALDEESAYLSAKLAALEAL
                     RGGFTTVADAGTRAPVDVAAIAQGTEEAGIRCVLGKIVSAGTGGPAHLARWHGHPLVHP
                     SLAIAVPEDATGPVIKRTADLCAEAGAVLQIHVNEHLASVERSLKSVGRRPVDYLHHLG
                     ALGPHTLGAHATLLTPTEMRQLADTGAAISYNPVASAWKGNAVAHATMLAALGVRFGTG
                     TDGTRGDGFRLVDAAETAQRLAYGLASGDSVCGAGHLWLEHATAGGADALGLGRVTGRI
                     AAGQAADYLLVDLAVPELTPSYDLGWELVRLAGRDQIRAVVVGGRLRIWEGWPPDWDAR
                     ALIARAATVGPEVVARAKIQRVEPR"
     misc_feature    7842..7857
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.58"
                     /tool="antismash"
     misc_feature    complement(7853..7867)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.6"
                     /tool="antismash"
     gene            7990..8916
                     /locus_tag="HRD51_RS22265"
                     /old_locus_tag="HRD51_21950"
     CDS             7990..8916
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016578883.1"
                     /locus_tag="HRD51_RS22265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_21950"
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="WP_235093920.1"
                     /sec_met_domain="RimK (E-value: 2.5e-09, bitscore: 35.9,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp_3 (E-value: 2.5e-06, bitscore:
                     26.5, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLCFLVEEQYRHDGMPQDVIGQLRAWGHRVDVLWPGRSLIRMSE
                     LSGAVAEGDHDAWVLKTVSGGPGLTLLEAAATTGLTTVNDVRAIRGVRDKALAAVIARA
                     SGLPVPMTYAAVRAEEFAEVPEAEFPLVVKPADGSSGRAVRLVERPDELAAGARATADG
                     TGDGMLIAQPYVPNSGTDLKVYCVAGDLYATERCSPLHPGRAVAERQVPLPAEVARIAA
                     EIGEVFGLDLYGVDVLLGPDGPVVVDINDFPSFRQVPDAVARVSAAVLRLARRGTDRAP
                     VPALPFIGHQRPPRPAAEAVGAVGGAR"
     gene            8913..9749
                     /locus_tag="HRD51_RS22270"
                     /old_locus_tag="HRD51_21955"
     CDS             8913..9749
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014057092.1"
                     /locus_tag="HRD51_RS22270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_21955"
                     /product="alpha-L-glutamate ligase"
                     /protein_id="WP_235093921.1"
                     /sec_met_domain="RimK (E-value: 1.9e-05, bitscore: 23.2,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVGVISADPGHPLLAATAAVLRGDGHRVGFVGPDGVPLAGGGEP
                     GGAAAPGALADVYLLKARTPQALALAGRLEGRGAPVVNSVAATARCQDRVEMAAMARAA
                     GVPFAETLRTATVGELVAAGPDLGFPLVLKSRDSRRHDLVARVDTPAGLAELAAAWSGE
                     TVIVQEFTANSGWDHKLWVVGGQLFAARRRSELSPGGRGPNQPLPPAALPFAWIEAALH
                     IGAVFGLEVYGVDVLHAGAGAAVIVDINAFPGVRGQVGAPEALAALALRRAESGAI"
     misc_feature    9753..9770
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.7"
                     /tool="antismash"
     misc_feature    complement(9755..9770)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.94"
                     /tool="antismash"
     misc_feature    complement(9777..9797)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.36"
                     /tool="antismash"
     gene            10001..12223
                     /locus_tag="HRD51_RS22275"
                     /old_locus_tag="HRD51_21960"
     CDS             10001..12223
                     /EC_number="4.2.3.-"
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009716662.1"
                     /locus_tag="HRD51_RS22275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_21960"
                     /product="terpene synthase family protein"
                     /protein_id="WP_235096057.1"
                     /sec_met_domain="T1TS (E-value: 1.4e-83, bitscore: 280.6,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPHPARLNPHLEAARAHSRKWAREMNMLEGSGIWDQRDLDAHDYA
                     LLCAYTHPECSQEALDLVTDWYVWVFFFDDHFLEKFKRTLDREGGKAYLDRLPAFMPMD
                     LDAPVPEPTNPVEAGLADLWRRTVPAMSPDWRRRFAESTEHLLNESLWELSNIDINRIP
                     NPVEYIEMRRKVGGAPWSAGLVEYATGAEVPAAVAGSRPLRVLKDTFSDAVHLRNDLFS
                     YQRETEEEGELSNGVLVLETFLDCTTQEAADAVNEMITSRLQQFEDTVFTELPTLFAEK
                     GLDPAGRAAVLAYAKGLQDWQSGGHEWHMRSSRYMNGGGAGAPGSAAAPWSPLVFGGLG
                     TEGLGASGADLATALAAAGAQRVRRRSHAPYEKVGPPRLPDFCMPFTTTHSPHLEAARR
                     NVVAWAHRMGLLQPQPGVPLSDVWDEDALVRFDFALCAAGLHPDATLDELDLGTQWLTW
                     GTYADDYYPAVFGRTGDVAGALATTRRLSALMPVDAADRAPEPTNALERGLVDLWARTA
                     GPMDPDARRAFKATVDAMTASWLWELDNMVLHRIPDPVDYIEMRRATFGSDLTMSLSRL
                     GHGRRVPPEIYRSGPMRSLENAAADYACLLNDVFSYQKEIEYEGEVHNGILVVQNFFDC
                     DYPTALAIVHDLMTSRMREFQHVARNQLPILYDDFDLSVEDRATLDGYVEELENWLAGI
                     LTWHRECGRYRPEHLRHRPGTPGWTPGPTGLGTSSARLTEALGAAR"
     misc_feature    complement(12396..12409)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.69"
                     /tool="antismash"
     misc_feature    12398..12414
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: strong, score: 25.09"
                     /tool="antismash"
     gene            12523..15078
                     /locus_tag="HRD51_RS22280"
                     /old_locus_tag="HRD51_21965"
     CDS             12523..15078
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018536571.1"
                     /locus_tag="HRD51_RS22280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_21965"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_235093922.1"
                     /transl_table=11
                     /translation="MTSENDRPDRPGGGAGEGPGRACDIATAAAAELDGRGVVVSWTRA
                     AERLLGYPATEVLGRSAVTLLAVPGDAARVAAVAHWAGDGWSGSVAARHRDGQAIQLAV
                     EVSPVITAATGGTAAPERWSVVALEEWRVPGGGVNQLMLEPFLAHAPVGMAVLDTDLRY
                     VWVNAVLERLIPLEQRLGRTVAQVLPRDEADAFEERMGQVLKTGKPVMDYEFRTRNFAD
                     PNQERAYSVSFFRLAGPKGRGVGIWYMVIDVTERWRAQEGLALLNDASARIGSTLDVTR
                     TAQELADVAVPPLADFVAVDLLDSVLRGEEPEPGPVDSTPTMRRAGQRSVREGCPEAAL
                     AVGEAVRRQPWSAIARCLLTGESVVEPLLNADSTWVAEDPRRADVVREYGFRSVMVAPV
                     RARGITLGAATFVRSRRQGLFDADDVRLAEELVARAAVCLDNARRFTRERTAARIMQRN
                     LLPHALAGGVALDVASWYFPADVPSGVGGDWFDVIPLSGARVALVVGDVVGHGIDAAAT
                     MGRLRTAVRTLANLDLPPDELLARLDDLVIGLMETRRDGGAGADDGTAATALGFMGATC
                     LYAVYDPVSRSCTMARASHLPPAVLAPDGAVDFPDLPAGPPLGLGALPFESAELELAEG
                     SLLALYTNGLLGTYDRDIGVGMARLGRALAEPGATLDEIGANVVSALLTGPPSDDAALL
                     LARTHALDASQVASWDLSADPAVVAGARNLAGRQLAAWGLEPLRFTTELVVSELVTNAI
                     RHGSGPITLRLIRQDAALICEVFDTGSTAPHLRHARTTDEGGRGLLIVAQLTRRWGTRY
                     TANGKIIWAEQGQGEPPRESSGETPGDPAPPVPAPHDAG"
     gene            15438..15614
                     /locus_tag="HRD51_RS22285"
                     /old_locus_tag="HRD51_21970"
     CDS             15438..15614
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016575967.1"
                     /locus_tag="HRD51_RS22285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_21970"
                     /product="hypothetical protein"
                     /protein_id="WP_159030874.1"
                     /transl_table=11
                     /translation="MNALKAALWCVLALAAVVNAFTSLAFDGAQQVVLSVGTGTAVIAS
                     AVVLFLMRERRRP"
     misc_feature    15687..15700
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 17.04"
                     /tool="antismash"
     misc_feature    15687..15701
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.38"
                     /tool="antismash"
     misc_feature    15688..15701
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.38"
                     /tool="antismash"
     misc_feature    complement(15689..15702)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.78"
                     /tool="antismash"
     misc_feature    15853..15867
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.48"
                     /tool="antismash"
     misc_feature    complement(15864..15878)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.8"
                     /tool="antismash"
     gene            15869..16069
                     /locus_tag="HRD51_RS22290"
                     /old_locus_tag="HRD51_21975"
     CDS             15869..16069
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HRD51_RS22290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HRD51_21975"
                     /product="hypothetical protein"
                     /protein_id="WP_205366000.1"
                     /transl_table=11
                     /translation="MTFKAFFPRNRINGGGGGGHGGHGHGGRGGWGYGYGGYGRGYGYG
                     RGFGYGYGFRGRGGRGFGFFR"
     gene            16601..18292
                     /locus_tag="HRD51_RS22295"
                     /old_locus_tag="HRD51_21980"
     CDS             16601..18292
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) ABC_efflux"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016575965.1"
                     /locus_tag="HRD51_RS22295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_21980"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_205370332.1"
                     /transl_table=11
                     /translation="MLLVGLCAIVAALAETVTILLFAQLTDQALAQGSVSAFWNPAGTW
                     LTVALLGAVVGYLGSSLAAWTAERFLLRLRARVFTHLQTLPPHFFQRNRRGDLVERLTG
                     DVDAIEHLVVSGLVSACTAVFSTLFYGAAALWLRWELALATFVAAPIFYAATRRFTGRL
                     REVSRRLRAADGALTSVVEETLVNVVLTQAYNRQRDEETRLSREALRWLRASVASARLN
                     ALYEQLIEVLETLCVLAIIGLGAWEISAGRMSLGQLLAFAAFIGYLYPPIRSLGQLGLT
                     ATAATAAADRLLEILDARPAVTDPPPERTTPFPHRARGELAVQDVTFRYPNAAPGHHAL
                     AALSFTAQPGAFLVVTGPSGAGKSTLAALLLRFYDPDAGTIRLDGIEVDRLSLADLRRN
                     ITLLPQETLVLHDTIEHNIACGRDHPTPTHEEVVQAARAADAHAFVTALPNGYDTVIAP
                     ATAALSGGQLQRIAIARAMLRDAPVLILDEPTTGLDTLAAQRILGPLHRLAAGRTTLVI
                     SHDLDLATGADLILVLDEGHLTESGTHPDLLARGGLYTELFESGRG"
     gene            complement(18337..19047)
                     /locus_tag="HRD51_RS22300"
                     /old_locus_tag="HRD51_21985"
     CDS             complement(18337..19047)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018536568.1"
                     /locus_tag="HRD51_RS22300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_21985"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_235093923.1"
                     /transl_table=11
                     /translation="MSVIQGARERARREVTAAIKGEARRQLATEGAAKLSLRAVARELG
                     MVSSALYRYFPSRDDLLTALIIDAYDAVGEAAEHALAGAGAGAAPVARWTAVCRAVRDW
                     ALEHPHEYALIYGSPVPGYAAPQATTASAARVGLALIGVVEDAYPAGVSPAPAAPSLPH
                     EVLDDAEELRKTLDVRLPAPVLAEIAAAWAELFGLVSFEVFGQFNRVIEARDAFFARAA
                     TRLAQNVGLAVGGE"
     misc_feature    complement(19084..19098)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     gene            19180..19641
                     /locus_tag="HRD51_RS22305"
                     /old_locus_tag="HRD51_21990"
     CDS             19180..19641
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009713338.1"
                     /locus_tag="HRD51_RS22305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_21990"
                     /product="nitroreductase family deazaflavin-dependent
                     oxidoreductase"
                     /protein_id="WP_235093924.1"
                     /transl_table=11
                     /translation="MSAGVEQHVIKPGWFTRNVFNRLVAALTRRGISVLGSQELAVRGR
                     KSGEWRCTPVNPLTVDGRQYLVAPRGHVQWTHNMRAAGGGELRIGKTARPFIATEVPDA
                     EKPELLRAYLKRWKAEVGVFFDGVGPDSSDEVLLGIAPKHPVFRITLGS"
     gene            19774..20307
                     /locus_tag="HRD51_RS22310"
                     /old_locus_tag="HRD51_21995"
     CDS             19774..20307
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HRD51_RS22310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HRD51_21995"
                     /product="hypothetical protein"
                     /protein_id="WP_235093925.1"
                     /transl_table=11
                     /translation="MSASDGEKSQLASLDAEAPSHGGVTTSEEALRDLRRQHLARGRSA
                     IDRARALCRFAGIGEQDARPVPTDPASKAATAVRLSAQALARVAEAPLDPAADARCARN
                     AAAAAAVVATAAQAHAGAGELPDAAHAAAVRASLASGQAAGQVGLGRDETLNRAADEAE
                     AAAVAAAKAAGWWV"
     gene            complement(20518..20967)
                     /locus_tag="HRD51_RS22315"
                     /old_locus_tag="HRD51_22000"
     CDS             complement(20518..20967)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089948.1"
                     /locus_tag="HRD51_RS22315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_22000"
                     /product="DoxX family membrane protein"
                     /protein_id="WP_205366004.1"
                     /transl_table=11
                     /translation="MQTTWLTGAEWFAVLRIGLGLWWLESWRHKDKKTWFTGGGITWAA
                     GIAAKHRWSAVRTGFDRIVRPRPRLMAYVVAYAELALGLGLVVGLLTPIALVAGLLLNL
                     IYLVLMIHDWAEQGQNLMMALISAVGFCALCWQSWSLDAVWGLFL"
     misc_feature    21976..21990
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 20.18"
                     /tool="antismash"
ORIGIN
        1 cggctccaga gcgcctacgc tctcgtgctg ggcgatgcgc tgccgcgaca gcagtccctg
       61 gccctgatga gggcaacaga aaaggagtac gggcaccatg actgagcgcg tcatcgcgaa
      121 tgccgcagca ctgagcggct ggcgcaagtc gtcgtacagc gacggcgaag gggccgaatg
      181 catggaggtc gtggatgacc acccccacgg catacccgtc cgcgactcca aggccccgca
      241 cgggccggcg atcgtggtac cggcgggggc ttggagcgcg ttcgtcgccg cggtgaaggg
      301 tgaggcgttc ggcgggcgtt aggcgagtac gcggcccaac gtggcgatcg ccgaggtcag
      361 ttcgttctcg gtgatggtca ggggcggggc caggcggatc gttgagccgt gggtgtcctt
      421 gaccaagacg ccctcggaca ggaggcgttc gctgatggtg cggccggtgc ccagggcggg
      481 gtcgatatcg acgccggccc acaggccgcg ggcgcggaag gcggtgacgc ccttgccgag
      541 gaggtcggtg aggccggagt gcaggacctt gcccaggtcg gcggcgtggg attggaattc
      601 gccggtggtg aggaggtcga cgacggccgt gccgacggcg gcggcgagcg ggttgccgcc
      661 gaaggtggag ccgtgttggc ccgggccgag gacggacatg acctcgcggc gggcgacgac
      721 ggcggagacg gggacgatgc cgccgccgag ggccttgccg aggaggatga cgtcggggac
      781 gacctgttcg tgttcgacgg cgagggtggt gccggtgcgg ccgaggccgg actggatttc
      841 gtcggcgatg aagaggcagt tcgcgcggct ggtcgcggcg cggacgccgg cgaggtagcc
      901 gtcgtcgggg atgatgacgc cggcctcgcc ctggatgggc tcgatcagga cggcggcggt
      961 ggtgtcgtcg atggcggctt cgagggcggc caggtcgttg taggggacgg tgcggaagcc
     1021 gggggtgtag gggccgaagc cggtgcgggc ctcgtcgtcg tcggagaagc tgatgatggt
     1081 cgtggtgcgg ccgtggaagt tgccgctggc gacgacgatg gtggcctggt cggcggggac
     1141 gcccttgacc tcgtaggccc atttgcgggc gagcttgatg ccgctctcga cggcctcggc
     1201 gccggtgttc atggggagga ccatgtccag gccggtgagc tcggccagcg cgccggcgaa
     1261 ctgcccgagg cggtcgtggt ggaaggcgcg ggaggtgagg gtgagggcgt ccagctggcg
     1321 gtgggcggcc tcgatgaggg ccgggtggcg gtggccgaaa ttgagcgccg agtagccggc
     1381 cagcatgtcg aggtagcggc ggccctcgac gtcctcgacc cagacgccct cggcgcggga
     1441 gatgaccacg gggagggggt ggtagttgtg ggccaggacc ggggcctcgg cctcgatgag
     1501 ggaggcggag gagcggcggg tgtcggtggg cgcagtcgtc atgggcgaag ctcctgggtg
     1561 cagcacttga tgccgccgcc ggccttgtgg aactcggaga ggtcgacggg gacggggacg
     1621 tatccgcggg cggtgagttg gtcgatgagg tgcgtggccc ggggggcgac gaagacgtgg
     1681 cggccgtcgg agaccgagtt gaggccgaag gccagggcgt cgtcgcgggt ggccagcacg
     1741 gcgtccggga agagctggcg gagcacttcg cggctgccgg gggagaaggc ttcggggtag
     1801 taggcgagag ccgccccgcc ggccccgttg ccgccggtgc ccattccgtc ggcggggagg
     1861 ccgtcggcgg cgaggccgtc gtcgaggacg aagagggcgg tgtccaggtg gtagaagtac
     1921 gggtcggtca gctggaggct gatcaccggg cggccgaaga actcctggac ctcggcgtgt
     1981 gcgtcgcggg tggtgcggaa gccggtgccg gcgaggaggt agcggccgac ggggacgagg
     2041 tcgccctcgc cctcgcaggg cgaggcgggc cggtggaggt cgtagccggc gcccttgaac
     2101 cagatctcgt actcgtggga ctcgggccgg cgctgcgggg cgtggaagag cgagccgaag
     2161 gcgcgaccgc ccacgacgac ggcggagttg gcggcgaaga ccatgtcggg caggccgagg
     2221 gccggccgga cggtctcgac ggtgtggccg tggtcgcggt aggcgcggac caggtcctcc
     2281 cactgccgca gggcgagtgc ggcatcgacg tcggcgtcct cgcgcatcca ggggttgatg
     2341 gcgtactcga cggcgaagtg ggtgggccgg cagagcagat agcgccgggc gcgcggcgtc
     2401 cggggcgccc gggtgagcgc gccgccgggg tgggtcatgg gcacagaaag ggcctccgct
     2461 tcctggggtc cgtatccact gcccgccggt cggcacgacg gtccgcacgc tccgtgggtc
     2521 cgtacggtcc gtcaccgggg gcaatacacg gtacgaagcg gcggattccg gccacaagaa
     2581 atgaatgctg cgcaggtacg caggaatgct gcttgtggcg gctggctagc gctggtttgc
     2641 tgcgcgtcgg agcggctgag gatggacccg agcgccgtcg ccggcccggc cggcggcctg
     2701 gtgggcggcc cggtcgtcgg ggcgggcggc ggaacggtcg tcggaaggac ggcgggcacc
     2761 ggcctcgggg ctgtccggga ggaggtgcga gagcaccatg tagctgatcg tcttccggat
     2821 gaacggctcg gtgcggatgc gttcgaggac ctcctcgaag tgctcgacgt cggtggcgcg
     2881 gacgtgcagc agggcgtcgg cgccgccggt gacggtcatc gcggcggcga tctccgggtg
     2941 gttgcggacg acctcggcca gccgccgggg cggggcggcg ctgtcgcagt agacctccac
     3001 gtacgcctcg gtgagccatc ccagggcggc ggggcggacg gtggcggaga aaccggtgat
     3061 gacgttggtc tcgcggaggc ggtccacgcg gcgtttgacg gcggtggggg acaggccgat
     3121 ggccgagccg atctcggcga agctggcgcg gccgttctcg atcagcgcgg cgacgatctt
     3181 gcggtccagt tcgtcgaacg gcgcggactt ggtgctcatg gtgcggccct ttcttcctct
     3241 cctcccccgc ccccgggccg ggtcgttacc cgtccccggg tcgggggagt gcagtcacgg
     3301 taaccgggac cggcgggtgg tggcgcagcg cccgggcgtc cggatacatc cccaggtcag
     3361 gcatgtgtgc aggtcaatgg tggtggcgta actccgccgt aacggggctt gcttagcgtc
     3421 gggggcccgg cgttcgctcg tcggggctca tggcaggcgg cgcggcgggg cgtgaggagg
     3481 gcgggcatgg acgcggacga cggcggggac ggccaccgcg gcggcgcggt cggcgacggg
     3541 ccgacgcggg cggaccgggc gcggcgggtg gcgcatgtgc tgcgcgggca ggtggtgcgg
     3601 ggcgcgttcg ccgggggcgt gctgcccgac gagcgggcgc tggtcgcgga gttcgggacc
     3661 tcgcgcaaca cggtccggga ggcgctgggg ctgctgcgcg acgaggggct ggtggagcgg
     3721 cggcgcgggg tggggacggt ggtcgtcggc cggacctacg agcatccgct gggggagctg
     3781 tccgggctgg ccgaggtgtt gcagcggcac gggacggtgg tcaacgaggt ccgggcggcg
     3841 cggatcgtgc gggcaccggg gtcggtggcg cgccgactgg agctgccgga ggggagccgg
     3901 gcggtgtatc tggagcggct gcggcgggtg gacgggatgc cgctgtccct ggactgcacg
     3961 tacctcatcc ccgaagtggg cgagccactg ctggcgttgg ggccggagcg gctggagaac
     4021 cgggacgtct tcgagctgat cgagcgcgcg gccgggcggc cgctggggtc ggcggaggtg
     4081 gccgtgcggg cggtggtcgc ggacccggcg acctgcgcgg tgctggggat ggcggcgggc
     4141 ggcgcggtgc tggccgtgga ccggctgacg cggctggcgg acgggcggcc ggccgacctg
     4201 gagttcatcc atctgcgcgg ggaccggctg acgctgcggg cgcggctgga ccgggtccgg
     4261 gaggggtgag ccggtgcggt cgggtcgggt gcccgcgcgg gcgccggtga cgtgcgcgat
     4321 gtgcctgtgc gtggcgctgg tcgtcggcat ggtctcggcg gtgaatctgg ccatcccgga
     4381 tctgtccgcc gggccgttgc acccgtccgc ggcggcggtg gtgtgggtgg tggacggcta
     4441 tgtggtggtg ttcgcctgcc tgctggtgcc ggccggggcg ctggccgacc ggcgcgggcg
     4501 caagggcacg ctgctgtgcg ggatggcggt gttcgtcctc ggctcggcgg tgtgcgcggt
     4561 ggcgccgcac gtcgaggtgc tgatcgcggg gcggatgatc agcggggtgg gggccgcggc
     4621 ggtgctgccg aacaccctcg cgctgctggt ggacgggctg tcggacgggc cgcgccgccg
     4681 ggcgatcgcg gtctgggcgg ccatgacggg gctcgccgcg gtgctgggca atgtgggcgg
     4741 gggcgcggcg atccagtacg ggagctggcg ggcgctgttc gtgtgcgtgg tgccggtggc
     4801 ggtgggcgcg tcggtgctgg tggcggtggt cgcgccggtg gcggggcggc atccggggcc
     4861 ggtcgcgccg ctggccgtgg ccctgttcac cggtgggttc ctggccctgc tgaacgggat
     4921 cgtgagcggg cccggggagg ggtggctcgg cccgtgggtg ctcgggtcgt tcggggcggc
     4981 cgggctgctg ctgacgggct gggcccggtg cgaactgcgc tccgcgcggc ccctgttgga
     5041 ccccagggtg ttcgcccgcc ccgccgtccg ggccggggcg gtcgggatgg cggtgctgtt
     5101 cctgggcatg ttcgggctgt tctacctcaa cggccagtac ctccagtacg cgaaggggta
     5161 cgggccgttc ggcgccggtg tgcggctgtt gccgatggcg gcggcgctgc tggcggggcc
     5221 ccggtgcggg ctggtgctgg agcgccggtg cgggcggcgc ggcacggtcg ccaccgggat
     5281 gctggtgctg gccggcgggc tggccacggt gtcggccgcc gatgccggta cgccgtacgc
     5341 gctctacgcc gtcggggccg ggctgaccgc gctgggctgc ggcaccgcga ccccgctgct
     5401 ctcgcacgcg atgatgtccg cgctgccgcc ggaggccgcc ggggtcggct ccggactgca
     5461 gagcctgacc cgggagttgg ggagcgcgct ggggatcgcg gtgaccggga cgctgaccgc
     5521 ggcggtgttc accgcccggc tgccggcgcc gctggcgggg cccggggcgc cgacgacggt
     5581 cgcggcggca caggccgcgc tcggagacct gccggaccgg ggcggggagc tgcggacggc
     5641 ggtgaccggg gccttcacgg acgggctgca cctggcgacg ctggtgctgg cggcgggggt
     5701 ggcggtggcg gcgggggcgg tcttccggtg gatgccccgg gagggggaag cggaagcggg
     5761 gacggcgcgc gcaagcgcag ggggcgggcc cctgacgcgc acggggtgat cgtcgggcca
     5821 cggggggcgt cgggcagaag cccgaggcgg gggccggtcc ccggccgtct cgccccggcc
     5881 gtctcgcccg gctgtttctc cccctggccc ggtagccaca ccccgcccgg ccgcgcctac
     5941 cgcggctcca cccgctggat cttggcccgc gcgaccacct ccggtcccac cgtcgccgcg
     6001 cgggcgatca gcgcgcgggc gtcccagtcg ggcggccagc cctcccagat gcggagccgg
     6061 ccgccgacca ccacggcgcg gatctggtcg cggccggcca gccggacgag ttcccagccc
     6121 aggtcgtagg agggggtgag ttcggggacg gcgaggtcca cgaggaggta gtcggcggcc
     6181 tgaccggcgg cgatccggcc cgtgacgcgg cccagcccga gggcgtcggc gccgcccgcg
     6241 gtggcgtgct ccagccacag gtgcccggcg ccgcacaccg agtcgcccga ggccagcccg
     6301 taggccagcc gctgggccgt ctcggccgcg tcgaccagcc ggaagccgtc gccgcgggtg
     6361 ccgtccgtac cggtgccgaa gcggacgccc agcgcggcca gcatggtggc gtgcgcgacg
     6421 gcgttgccct tccaggcgct ggccaccggg ttgtagctga tcgccgcgcc ggtgtcggcc
     6481 agctgccgca tctccgtggg cgtcaggagg gtggcgtgcg cgcccagggt gtgcgggccg
     6541 agggcgccga ggtggtgcag gtagtccacc gggcggcggc cgacgctctt caacgagcgc
     6601 tccacggagg ccaggtgttc gttgacgtgg atctggagca ccgccccggc ctcggcacag
     6661 aggtcggcgg tccgtttgat gaccgggccg gtggcgtcct cggggacggc gatggccagg
     6721 gaggggtgga cgagcggatg gccgtgccag cgcgccagat gggccgggcc gccggtcccg
     6781 gcggagacga tcttgcccag gacgcaccgg atgccggcct cctcggtgcc ctgggcgatc
     6841 gcggccacgt cgaccggcgc ccgggtcccg gcgtcggcga cggtggtgaa gccgccgcgc
     6901 agcgcctcca gcgcggccag cttcgccgac agataggcgc tctcctcgtc cagggcgtgt
     6961 tccagcggct cccagacggt cttgaagatc tccgacggct ggccgaacga ctgggccttg
     7021 ccgaagccct gggtcaggtg gtggtgggcg tcgacgaagc cgggcatcag gaggtggccg
     7081 ggcaggcgga tcggggcggg gccggcgcgg tgcgcggcga ggagccgggc cgccggaccg
     7141 acctcgcgga aggtgccgtg ctcgacgagg acggcgtggt cgcgcaccgg gccgtccggc
     7201 agcagcacca catccgggac gaggagctgg cggggaccgg cgaagtggtc ggggcggagg
     7261 gcggggtggg cgtcccgggg ctgcgcggag gcggtgccgg cgcccggtcc gccgagcagg
     7321 ccgccggcgc cggtcagccc ggccaccccg gcgaggaagc cgcgccgacc gaggccgccg
     7381 cgggggtcgg ccccttcggg cgccgcgccg gatgccgcgt cggacgcccc gtcgtgggcc
     7441 gctgcgctcc gtatgccgtc cggccgttcg ccgtccggcc gttcgccgtc cggccgttcg
     7501 ccgtccggcc gttccgcgtc cggacacccg ccgggagccc cggcctcctg gggctcccgg
     7561 ccccgctgct cgttcgccaa cccgctcgcc tgcttccgtc gccgcgtacg taggcgcggc
     7621 cgggcccgtg atcgggtcgg ccgcgctggg tggcccgacc ctagggtcgg gccataaagc
     7681 ggaacaaggc tttcgacata cgggatttgg tgaggtcgcg gaggagtggc gcaaccccgc
     7741 gcggggcgtg gcgcgtccca gctcacggcg tgtgccgagg tcccgtccgg tggcgtaacg
     7801 tcgccgaaac gggagctccg ggggcggcgg ccgggccatg gccgaacgcc tgatcgccac
     7861 atgggatcct ggtgcgtcat gtttccgccg ggcggacggt gtgcgtacgg cgacacgggg
     7921 aggacgtccg ctgctgtggt gggcgggttg gcgatacggg tggacgtgcg gcgatacaag
     7981 ggtgcatcga tgagactctg cttcctggtg gaggagcagt accgccacga cggcatgccg
     8041 caggacgtga tcggtcaact ccgcgcgtgg ggacaccggg tggacgtgct ctggccgggc
     8101 cgttcgctga tccggatgtc cgagttgtcc ggcgcggtgg cggagggcga ccatgacgcc
     8161 tgggtgctca agaccgtctc cggcgggccc gggctgaccc tcctggaggc cgccgcgacc
     8221 accggactga ccaccgtgaa cgacgtacgc gccatacggg gcgtacggga caaggcgctc
     8281 gccgcggtga tcgcgcgggc cagcgggctg ccggtgccga tgacgtacgc ggcggtgcgg
     8341 gccgaggagt tcgccgaggt ccccgaggcg gagttcccgc tggtggtgaa gcccgcggac
     8401 ggcagctcgg ggcgcgcggt gcggctggtg gaacggcccg acgagctggc tgccggggcc
     8461 cgggcgacgg ccgacggcac cggcgacggc atgctgatcg cccagcccta cgtccccaac
     8521 tccggtaccg acctgaaggt ctactgcgtc gccggcgacc tctacgcgac cgagcgctgc
     8581 tccccgctgc acccggggcg ggccgtggcg gaacggcagg tgccgctgcc cgccgaggtc
     8641 gcccggatcg ccgccgagat cggcgaggtc ttcggcctcg acctgtacgg ggtcgatgtg
     8701 ctgctggggc cggacgggcc ggtggtggtc gacatcaacg acttcccgag cttccggcag
     8761 gtgccggacg cggtcgcccg ggtctccgcg gcggtgctgc ggctggcccg gcgcggcacc
     8821 gaccgcgctc cggtgccggc gctgccgttc atcggccacc agcggccccc gcggccggcg
     8881 gccgaggcgg tcggggcggt cgggggcgca cgatgagggt cggtgtgatc agcgccgatc
     8941 ccgggcaccc gctgctggcg gcgacggcgg cggtgctgcg cggggacggt caccgggtcg
     9001 gcttcgtcgg cccggacggt gtgcccctcg ccgggggagg ggagccgggc ggggccgccg
     9061 cgcccggggc gctcgccgac gtctatctgc tcaaggcgcg gacgccgcaa gcgctggcgc
     9121 tcgccggccg gctggagggc cggggcgcgc cggtcgtcaa ctccgttgcg gcgacggccc
     9181 gttgtcagga ccgggtggag atggccgcga tggcccgggc ggccggagtg ccgttcgcgg
     9241 agacgctgcg gacggcgacg gtcggcgagc tggtggcggc cgggccggat ctcggcttcc
     9301 cgctcgtcct caagagccgc gacagccgcc gtcacgacct cgtggcgcgc gtcgacaccc
     9361 cggccggact ggcggagctg gccgcggcat ggtcgggcga gaccgtgatc gtccaggagt
     9421 tcaccgccaa cagcggttgg gaccacaagc tgtgggtcgt cggcgggcag ctcttcgccg
     9481 cccgtcgccg ttccgaactg tccccgggcg ggcgcggtcc gaaccagccg ctgccgcccg
     9541 ccgccctccc cttcgcctgg atcgaggccg cgctgcacat cggcgcggtc ttcggcctgg
     9601 aggtctacgg tgtcgacgtg ctgcacgccg gggccggcgc cgcggtgatc gtggacatca
     9661 acgccttccc gggtgtccgc ggccaggtgg gggccccgga ggcgctggcg gcgctggcgc
     9721 tccgccgggc cgagagcggt gccatatagc ccatgtgacc catgtgtcac atctcttcat
     9781 cgccaactca actcgaaaga gtgccggttc agcgcgggtg tgacccgacg agcctacggc
     9841 gacgaacctc ggggtagggc tgcgccgtcc atggggtgct tcggcgcgcc ctccttccgt
     9901 acacaccgtc cgtgcggagg ggcatcggta tcgggagagg ccaccaacgg tgacgcagcc
     9961 gcagcccacg tcgcaaccct tcaccttgcc gcacttctac atgccgcatc cggcccggct
    10021 gaacccgcac ctggaggccg cgcgggcgca ctccaggaag tgggcccggg agatgaacat
    10081 gctggaaggt tccggcatct gggaccagcg ggatctcgac gcccacgact acgcgttgct
    10141 gtgcgcctac acccacccgg agtgctccca ggaggcgctc gacctcgtca ccgactggta
    10201 cgtctgggtc ttcttcttcg acgaccactt cctggagaag ttcaagcgca ccctggaccg
    10261 ggagggcggg aaggcgtacc tcgaccggct gccggcgttc atgccgatgg atctggacgc
    10321 gcccgtgccg gagccgacca acccggtcga ggcggggctg gcggacctgt ggcggcgcac
    10381 cgtgcccgcg atgtcgccgg actggcgccg acggttcgcc gagagcaccg agcacctgct
    10441 gaacgagtcc ctctgggaac tctccaacat cgacatcaac cggatcccca accccgtcga
    10501 gtacatcgag atgcgccgca aggtgggcgg cgccccctgg tcggcggggc tggtggagta
    10561 cgcgaccggc gccgaggtcc cggcggcggt cgccggctcc cgccccctcc gggtcctcaa
    10621 ggacaccttc tccgacgccg tccacctccg caacgacctc ttctcgtacc agcgcgagac
    10681 cgaggaggag ggggagttga gcaacggcgt gctggtactg gagacgttcc tggactgcac
    10741 cacccaggag gccgcggacg cggtcaacga gatgatcacc tcgcggttgc agcagttcga
    10801 ggacaccgtc ttcaccgaac tgccgacgct cttcgccgag aagggcctgg acccggccgg
    10861 ccgcgccgcc gtcctcgcgt acgccaaggg cctccaggac tggcagtccg gcggccacga
    10921 gtggcacatg cgctccagcc gctacatgaa cggcggcggc gcgggcgcgc ccggcagcgc
    10981 cgcggccccc tggtcgccgc tggtcttcgg cgggctgggc accgaggggc tgggcgcctc
    11041 gggcgccgac ctggcgacgg ccctggccgc ggccggcgcc cagcgggtcc gccgccgctc
    11101 ccacgccccg tacgagaagg tcggcccgcc ccgactcccc gacttctgca tgccgttcac
    11161 caccacccac agcccccacc tggaggcggc ccggcgcaac gtcgtcgcct gggcgcaccg
    11221 gatgggactg ctccagccgc agcccggcgt cccgctgtcc gacgtctggg acgaggacgc
    11281 cctggtccgc ttcgacttcg cgctgtgcgc ggccggtctg caccccgacg ccaccctcga
    11341 cgagctcgac ctcggcaccc agtggctgac ctggggcacc tacgccgacg actactaccc
    11401 tgcggtcttc ggccggaccg gcgacgtcgc cggtgccctg gccaccaccc ggcggctgtc
    11461 cgccctgatg ccggtcgacg ccgccgaccg ggccccggaa ccgaccaacg ccctcgaacg
    11521 cggactggtc gacctctggg cccgtacggc cgggccgatg gacccggacg cgcgccgcgc
    11581 cttcaaggcc accgtcgacg cgatgaccgc cagctggctc tgggagctgg acaacatggt
    11641 gctgcaccgc atcccggacc cggtcgacta catcgagatg cgccgcgcca ccttcggctc
    11701 cgacctcacc atgagcctga gccggctcgg ccacggccgt cgggtgccgc cggagatcta
    11761 ccgcagcggc ccgatgcggt cgctggagaa cgccgccgcc gactacgcct gcctgctcaa
    11821 cgacgtcttc tcgtaccaga aggagatcga gtacgagggc gaggtccaca acggcatcct
    11881 cgtcgtgcag aacttcttcg actgcgacta ccccaccgcg ctggccatcg tccacgacct
    11941 gatgacctcc cggatgcgcg agttccagca cgtcgcgcgg aaccaactcc cgatcctcta
    12001 cgacgacttc gacctctccg tcgaggaccg cgccaccctc gacggctatg tcgaggaact
    12061 ggagaactgg ctcgccggca tcctcacctg gcaccgcgag tgcggccgat accgccccga
    12121 acacctccgc caccggcccg gtacacccgg ctggacgccg gggccgacgg gcctggggac
    12181 gtcgtcggca cgcctgacgg aggcgctcgg ggcggcccgc taggagaagg ggggacgggg
    12241 cccggcggcc aggtggcgcg ccggatccct ccgcgtccgc gacgccgtcg aggtggacgt
    12301 gcgggcgggg tggtgacgga gcgcgggtgg ggggccgcgc agggcgactg atccgccgga
    12361 agggtcggcc cgcggcaagt gatcccatat gtcgtattgc ttctaaaatg ggcatggtgt
    12421 gggcgtctgt gacaccgccg aggacgccgg tggaccgcga cggcagccac gccgcggcgg
    12481 cagcgcccgg gacagaaccg gctgcgacgg actggcgatg cgatgacctc ggagaatgac
    12541 cggccggaca ggccgggcgg cggggcgggc gaggggccgg gccgggcctg tgacatcgcc
    12601 accgcggccg cggccgagct ggacgggcgc ggggtggtgg tctcctggac gcgggcggcg
    12661 gaacggctgc tgggctaccc ggcgacggag gtcctggggc gcagtgcggt gacgctgctg
    12721 gccgtaccgg gggatgcggc gcgggtcgcc gcggtggccc actgggcggg ggacgggtgg
    12781 agcgggtcgg tggcggcccg gcaccgggac gggcaggcga tacagctggc ggtggaggtg
    12841 tcgccggtga tcaccgcggc gaccggcggg acggccgcgc ccgagcggtg gtcggtggtc
    12901 gcgctggagg agtggcgggt gcccggcggc ggggtgaacc agctgatgct ggaaccgttt
    12961 ctggcccatg ccccggtcgg catggccgtc ctggacaccg acctgcgcta cgtctgggtg
    13021 aacgcggtgc tggagcgcct gatcccgctg gagcagcggc tggggcgcac ggtcgcccag
    13081 gtgctgccgc gggacgaggc cgacgccttc gaggagcgga tgggacaggt gctgaagacc
    13141 gggaagccgg tcatggacta cgagttccgc acccgcaact tcgccgaccc gaaccaggag
    13201 cgggcctact cggtgtcgtt cttccggctc gccggcccca aggggcgggg cgtgggcatc
    13261 tggtacatgg tcatcgacgt caccgagcgc tggcgggccc aggaagggct ggcgctgctg
    13321 aacgacgcca gcgcccggat cggcagcacc ctcgacgtga cgcggaccgc gcaggagctg
    13381 gccgatgtgg cggtgccgcc gctggccgac ttcgtggcgg tcgatctgct ggactccgtg
    13441 ctgcgcggag aggagccgga gcccgggccg gtggacagca ccccgacgat gcggcgggcc
    13501 gggcagcggt cggtccgcga ggggtgcccg gaggccgccc tggcggtcgg cgaggcggtc
    13561 cggcggcagc cgtggtcggc gatcgcgcgg tgcctgctca ccggggagtc ggtggtggag
    13621 ccgctgctga acgccgacag cacctgggtg gccgaggacc cgcggcgggc cgacgtggtg
    13681 cgggaatacg ggttccggtc ggtgatggtg gcgccggtcc gggcccgcgg catcacgctc
    13741 ggcgcggcga ccttcgtccg ctcccggcgg caggggctct tcgacgcgga cgacgtgcgg
    13801 ctggccgagg agctggtcgc ccgcgccgcg gtgtgcctgg acaacgcgcg ccgcttcacc
    13861 cgcgagcgca ccgcggcccg gataatgcag cgcaatctgc tgccgcacgc actggccggc
    13921 ggggtggcgc tggacgtggc gtcctggtac ttcccggcgg acgtcccgag cggggtgggc
    13981 ggcgactggt tcgacgtgat cccgctgtcg ggggcgcggg tggcgctggt ggtcggggac
    14041 gtcgtcgggc acggcatcga cgccgcggcc accatgggcc ggctgcggac cgcggtccgg
    14101 accctggcca acctggacct gccgccggac gaactcctcg cccgcctcga cgacttggtg
    14161 atcgggctga tggagacccg ccgggacggc ggcgcgggcg ccgacgacgg cacggccgcc
    14221 accgcgctgg gattcatggg cgccacctgc ctgtacgcgg tgtacgaccc ggtcagccgg
    14281 tcctgcacga tggcccgcgc cagccatctg ccgcccgcgg tcctcgcccc cgacggcgcc
    14341 gtggacttcc ccgacctgcc cgccggaccg ccgctcggcc tgggtgcgct gcccttcgaa
    14401 tcggccgaac tggagctggc cgagggcagt ttgctggcgc tctacaccaa cggcctgctg
    14461 gggacctacg accgggacat cggggtgggc atggcccggc tcggtcgcgc cctggcggag
    14521 cccggcgcga cgctcgacga gatcggcgcg aacgtcgtgt cggcgctgct gaccggcccg
    14581 ccgtccgacg acgccgcgct gctgctggcc cgcacgcatg ccctggacgc cagccaggtc
    14641 gcctcctggg acctgtccgc cgacccggcg gtggtcgccg gcgcccgcaa cctcgccggg
    14701 cggcagctgg cggcgtgggg gctggagccg ctgcgcttca ccaccgaact ggtcgtcagc
    14761 gaactggtca ccaacgccat ccggcacggc agcggcccga tcaccctgcg cctgatccgc
    14821 caggacgccg ccctgatctg cgaggtcttc gacaccggca gcaccgcccc gcacctgcgg
    14881 cacgcccgga ccacggacga gggcggccgc gggctgctga tcgtcgccca gctcacccgc
    14941 cgctggggca cccgctacac ggccaacgga aagatcatct gggcggaaca ggggcagggg
    15001 gaaccgccgc gggagtcctc gggggagacg ccgggggatc cggcgccgcc cgtccccgcc
    15061 ccgcacgacg cgggctgacg caggttggcg cggcgtcagt cgccgtgcgg accccaccgc
    15121 tgtcgccgcc gccactgcgc atgcaccgtc accatcccgc cggcgccgaa cagttcacgt
    15181 cccttccggg ccgacgaacg ggcggtggcg ctgcacggcg tacctcgacg taccccgacg
    15241 cacctcggag tacctcgggg gtgcagctcg atgtaccccc gatccggggg cgctccccct
    15301 cgtccccggc ccgcgcgccg ggcatcgtgg tggacgggtc gagcgcacag ggtcaccgtc
    15361 gctgacgcgg cgtccgcgac gcgcccgcgt gccttgcgcc cctcggatcc accacgcccg
    15421 gaaggacacc gtcaccgatg aacgccctga aagccgcgct ctggtgcgta ctggccctcg
    15481 ccgccgtcgt caacgccttc accagcctcg ccttcgacgg cgctcagcag gtcgtgctga
    15541 gcgtcggcac cggcacggcc gtcatcgcct cggccgtggt cctgttcctg atgcgcgaaa
    15601 ggcggcgccc ctgacgcggt ttcggcccac cgcgtcgacc gcgagcgacc accctcccac
    15661 ccacagtgac atgtaccgca tgtctgaatt ttcacataaa gcccttgttg gggatgggcg
    15721 gccgacgtag tgtcggaagt gtcgcggaca gaacgttcct ccggaacgca ccgcacggga
    15781 cgccccggcg ggaacgcgcc gaatcgccgt acagagcacg gtccggctga aggccgcggc
    15841 gcacagtccg atttctcagg aggcgaagat gaccttcaag gcattcttcc cccgtaaccg
    15901 catcaatggc ggaggaggcg gcggccacgg tggtcacggt cacggaggcc gcggaggctg
    15961 gggctacggc tacggcggct acggacgcgg ctacggctac ggacgcggct tcggctacgg
    16021 ctacggattc cgcggacgtg gcggacgtgg cttcggcttc ttccggtgac atcccgtccg
    16081 ttgccgtgcc ggtgaaacgg cacacggcaa ctgacgatca ctgacatgtg attcgggccg
    16141 acggacccga cgcactgccc gaggcgggct cgcatgtgcg acgcgagccg gcctcgtggc
    16201 ctgccgaccc cgtgatcgac ggcccgcacc acacgtggcg accatgcatc cccgtaaggc
    16261 agaactgccc taccccgtac cggagtccac cggcccggag ccggaaccgg acccgtcgcg
    16321 gcagcgcgaa ccggcgccga cccaggaccg ctcgccgaca ccgccgcagc caccgtcacc
    16381 ggcgacgcca caggcgtcga gacggggcgc gacaccggaa gaggcgcagc ggcagccgcg
    16441 gcctccgtcg ccgccgcagg gacaggagcg gccgcaggcc cccgcccccg ccggcatccg
    16501 cggtcaactc cccaccgaag cgcccatcct gacccgccac gtcggcgccg tcgaggcgtt
    16561 ccaccgcttc tggccgctga ccaagggcga ccgccgctgg atgctgctgg tgggactgtg
    16621 cgccatcgtc gccgcgctcg ccgagaccgt cacgatcctg ctcttcgccc aactcaccga
    16681 ccaggccctc gcacagggct cggtcagcgc cttctggaac cccgccggca cctggctgac
    16741 ggtcgcgctg ctcggcgcgg tggtgggcta cctcggcagc tccctcgcgg cctggaccgc
    16801 ggaacgcttc ctgctgcgcc tacgggcccg ggtcttcacc cacctccaga cgctgccgcc
    16861 gcacttcttc caacgcaacc gccgcggcga cctcgtggaa cggctgaccg gtgacgtcga
    16921 cgccatcgaa cacctcgtgg tcagcggcct ggtgagcgcc tgcacggccg tcttcagcac
    16981 gctcttctac ggcgccgccg cactctggct gcgctgggaa ctggcgctgg ccaccttcgt
    17041 cgccgccccg atcttctacg ccgccacccg tcgcttcacc ggccgactgc gcgaggtctc
    17101 ccgacgcctg cgggcggccg acggcgccct cacctccgtc gtcgaggaga cgctggtcaa
    17161 cgtcgtcctc acccaggcgt acaaccggca gcgcgacgag gagacccggc tgagccggga
    17221 ggcactgcgc tggctgcgcg cctcggtcgc cagcgcccgc ctcaacgccc tctacgagca
    17281 gctcatcgag gtcctggaga ccctctgcgt gctggccatc atcggcctcg gcgcctggga
    17341 gatctcggcc ggccggatga gcctcggcca actcctcgcc ttcgccgcct tcatcggcta
    17401 cctctacccg ccgatccggt ccctgggcca actcggcctg accgccaccg ccgccaccgc
    17461 ggccgccgac cggctgctgg agatcctcga cgcccgcccg gccgtcaccg acccgccacc
    17521 cgagcgcacc acacccttcc cgcaccgcgc ccgcggcgaa ctcgccgtcc aggacgtcac
    17581 cttccgctac ccgaacgccg cccccggtca ccacgccctc gccgcgctct ccttcaccgc
    17641 gcagccgggc gcgttcctgg tcgtcaccgg ccccagcggc gccgggaagt ccaccctcgc
    17701 cgcgctcctg ctgcgcttct acgacccgga cgcgggcacc atccggctcg acggcatcga
    17761 ggtcgaccgg ctctccctgg ccgacctccg ccgcaacatc accctgctcc cccaggagac
    17821 cctcgtcctg cacgacacca tcgagcacaa catcgcctgc ggccgggacc accccacccc
    17881 gacccacgag gaagtcgtcc aagccgcccg ggccgccgac gcccacgcct tcgtcaccgc
    17941 cctcccgaac ggctacgaca cggtcatcgc gcccgccacc gccgctctct ccggcggcca
    18001 gctgcaacgc atcgccatcg cccgcgccat gctccgcgac gccccggtcc tcatcctcga
    18061 cgagcccacc accggcctgg acaccctcgc cgcccagcgc atcctcggcc ccctccaccg
    18121 cctcgccgcc ggccgcacca ccctcgtcat cagccacgac ctcgacctcg ccaccggcgc
    18181 cgacctcatc ctcgtcctcg acgagggcca cctcaccgaa tccggcaccc accccgacct
    18241 cctcgcccgc ggcggcctgt acacagaact cttcgaaagc ggccgcggct gaacgggggc
    18301 ggcgtcccgc gccccgtcgt gctactcccc gtcgtgctac tccccgccga ccgcgaggcc
    18361 gacgttctgg gcgagtcggg tggcggcgcg ggcgaagaag gcgtcgcggg cctcgatgac
    18421 gcggttgaac tggccgaaga cctcgaagct caccaggccg aagagctcgg cccaggcggc
    18481 ggcgatctcc gccaggacgg gggcgggcag gcgtacgtcg agggtcttgc gcagctcctc
    18541 ggcgtcgtcc agcacctcgt gcggaagcga cggcgcggcc ggtgcggggg agacgccggc
    18601 cgggtacgcg tcctcgacca cgccgatcag ggcgaggccg acgcgggcgg cggacgcggt
    18661 ggtggcctgg ggcgcggcgt agccggggac gggtgagccg tagatgagcg cgtactcgtg
    18721 cgggtgctcc aacgcccagt cgcggacggc gcggcagacc gcggtccacc gggcgacggg
    18781 tgcggcgccc gcgccggccc cggcgagggc gtgctcggcc gcctcgccca ccgcgtcgta
    18841 ggcgtcgatg atcagcgccg tgagcaggtc gtcgcggctg gggaagtacc ggtacagcgc
    18901 ggaggagacc atcccgagct cgcgggcgac ggcacggagc gagagcttgg cggctccctc
    18961 ggtggcgagc tgccggcggg cctcgccctt gatggcggcg gtgacttccc tgcgtgcgcg
    19021 ttcccgcgct ccctggatga cgctcatggg gccagtctgc catcggagcg agcggcgacc
    19081 aatatcgaga gcactgctct tgctttgcgg atccgcgcca tgcacactgc tctacagaga
    19141 gagcgccgct cacactttca cttctccggg aggaccccca tgagcgcagg cgtcgagcag
    19201 cacgtcatca agccgggctg gttcacccgc aacgtgttca accggctcgt cgccgcgctc
    19261 acccggcgcg gcatcagcgt gctcgggtcc caggaactgg cggtgcgcgg ccgcaagagc
    19321 ggggaatggc ggtgcacccc ggtgaacccg ctcaccgtgg acggtcggca gtacctcgtc
    19381 gcgccgcgcg gccatgtgca gtggacccac aacatgcgcg ccgccggcgg cggcgaactc
    19441 cgcatcggga agacggcgcg gccgttcatc gccaccgagg tcccggacgc cgagaagccc
    19501 gagctgctgc gcgcctacct caagcgctgg aaggccgagg tcggcgtctt cttcgacggc
    19561 gtcggcccgg actcctccga cgaggtgctg ctgggcatcg cgcccaagca ccccgtcttc
    19621 cgcatcacgc tcggctcctg acccgtcggg catgaccctg gtctcttcgc gccgcgcgtg
    19681 gcaccctgcc cggcgcaccg tcggcgcctc ggacacggct ccgcgccgcg gtgcgcccga
    19741 gcccgagtgg gcccaacgga caaggaggcg ggcatgagtg catccgatgg tgagaagtcg
    19801 cagctcgcgt cgctcgatgc ggaggcgccg tcccacggcg gggtgacgac ctccgaggaa
    19861 gccttgcggg acttgaggag gcagcacctc gcccgggggc ggagtgcgat cgaccgcgcg
    19921 agggccctgt gccgtttcgc cggcatcggg gagcaggacg cgcgcccggt gccgacggat
    19981 cccgcctcga aggcggccac ggccgtccgg ctgtccgccc aggcgctcgc gcgggtcgcc
    20041 gaggcgcccc tcgatccggc ggccgacgcc cgttgcgcgc ggaacgcggc cgcggccgcg
    20101 gcggtcgtcg ccacggccgc ccaggcgcac gcgggggccg gcgagctccc ggacgccgcg
    20161 cacgccgccg ccgtgcgggc ttccctggcc agtgggcagg cggcgggcca ggtgggcctg
    20221 ggccgggatg agacgctgaa ccgtgcggcg gacgaggcgg aggcggcggc ggtggccgcg
    20281 gccaaggcgg cggggtggtg ggtctaaggt ccgcccgccc ctgccccatc agacccatca
    20341 gacccatcag acccatcgga caggccctgg gagagggcgg aacggggcgg gccgcccgtc
    20401 ggggcgggcc cggatcgccc ggtgtccgcc ccggcgctcc gcccgccccg acccctcacc
    20461 gtcacgggcg gagcacccac ccgccgccgt cacgggcgga gttgcccctc gccgccgtca
    20521 caggaacagc ccccagacgg cgtccagtga ccagctctgc cagcacagcg cgcagaagcc
    20581 gacggcggag atcagcgcca tcatgaggtt ctggccctgc tccgcccagt cgtggatcat
    20641 cagcacgagg tagatcaggt tgagcagcag ccccgcgacc agggcgatcg gcgtcagcag
    20701 cccgacgacc agtccgagcc cgagcgcgag ttccgcgtag gcgacgacgt aggccatcag
    20761 tcgcgggcgg ggccgcacga tgcggtcgaa gccggtgcgg accgcggacc agcggtgttt
    20821 ggcggcgatg cccgccgccc aggtgatgcc gccgccggtg aaccaggtct tcttgtcctt
    20881 gtggcgccag ctctccagcc accacaggcc gaggccgata cgtagcaccg cgaaccactc
    20941 ggcaccggtg agccaggtcg tctgcatgcg aaccgctcct ctcgaccctg cacgggatct
    21001 gatggggcgt cagttcagcg gacggtgcgc gaacgcgcaa ggggtcgagt ttccggccct
    21061 cccttgtggt cgcagggtgg agctcctaac ctccgaactg atgggtcgtc agattttggg
    21121 ccggagtgac tcaccggcac ggcagttggg ggtagagcgt gaccagcggc aacggcgaca
    21181 acagcggcac ggcggagctt ccgaaggtca tcagcgtgga cgaccacgtg atcgaaccgg
    21241 cgcacctctt cgagacgtgg ctcccgcgga agtaccaaga ccgcggcccg aaacccctca
    21301 ccgccggcat cggtgagctg gcgtacgtcg gcggcaagta ccgcttcacc acggacccgg
    21361 agggccaggt caccgactgg tgggagtacg aggggcagct gttcccgtac aagcgcatca
    21421 tcgcggccgt cggcttctcc cgcgacgaga tgacgctcga cggcatcacg cgcgaccaga
    21481 tgcggcgcgg ctgctgggac cccaaggccc ggctggcgga catggacgtc aaccacgtcg
    21541 aggcgtcgct ctgcttcccg accttcccgc ggttctgcgg ccagaccttc gccgaggcag
    21601 aggacaagga ggtcgggctg gcctgcgtcc gcgcctacaa cgactggatg gtggaggagt
    21661 ggtgcggcga cagcggcggc cggctgatcc cgctgtgcct gatccccctg tgggacatcg
    21721 acctcgccgt cgccgagatc aagcgcaacg ccgcgcgcgg cgtccgggcg gtcaccttca
    21781 gcgagatccc cacctacctg ggcctgccgt ccatccactc cggctactgg gacccgttct
    21841 tcgcggcctg cgaggagacc gggacggtgg tgaacatgca catcgggtcg tcgtcgcaga
    21901 tgccggcggc ctccccggac gcgccgccgg ccgtacaggc gtcgctgagc ttcaacaacg
    21961 cgatggcctc gatgatggac ttcctgttca gcggggtgct ggtgaagttc ccccggctga
    22021 aactcgccta cagcgagggc cagatgggct ggatcccgta cgccctggaa cgggccgacg
    22081 acgtctggga ggaacaccgg gcctggggcg gggtgaaggg tctcatcccc gagccgccgt
    22141 cgacgtacta ctaccggcag atcttctgct gcttcttccg tgacaagcac ggcatcgagg
    22201 cgatcgaaac ggtcggggtc gac
//
