LOCUS       NZ_CP054019            22757 bp    DNA     linear   CON 28-JAN-2024
DEFINITION  Streptomyces sp. A1-5 chromosome.
ACCESSION   NZ_CP054019
VERSION     NZ_CP054019.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. A1-5
  ORGANISM  Streptomyces sp. A1-5
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9459690)
  AUTHORS   Dashti,Y., Sumang,F.A.M., de los Santos,E.L.C., Alcantara,E.P. and
            Challis,G.L.
  TITLE     Structural revision and biosynthesis of polyketides FXJ15321 and
            FXJ15322 from Streptomyces sp. A1-5
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9459690)
  AUTHORS   de los Santos,E.L.C.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAY-2020) Warwick Integrative Synthetic Biology
            Centre, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL,
            United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: JUN-2019
            Assembly Method                   :: Flye v. 2.4.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology :: Oxford Nanopore MiniION; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/28/2024 04:28:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,328
            CDSs (total)                      :: 8,230
            Genes (coding)                    :: 7,847
            CDSs (with protein)               :: 7,847
            Genes (RNA)                       :: 98
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 74
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 383
            CDSs (without protein)            :: 383
            Pseudo Genes (ambiguous residues) :: 0 of 383
            Pseudo Genes (frameshifted)       :: 156 of 383
            Pseudo Genes (incomplete)         :: 280 of 383
            Pseudo Genes (internal stop)      :: 26 of 383
            Pseudo Genes (multiple problems)  :: 73 of 383
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:08:01
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6853
            Orig. end                         :: 29610
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP054019.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Philippine National
            Collection of Microorganisms.
FEATURES             Location/Qualifiers
     region          1..22757
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-iv"
                     /region_number="1"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /tool="antismash"
     cand_cluster    1..22757
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22757
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:12757](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12757
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
     misc_feature    765..783
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.37"
                     /tool="antismash"
     gene            1312..1518
                     /locus_tag="HRD51_RS00040"
                     /old_locus_tag="HRD51_00035"
     CDS             1312..1518
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HRD51_RS00040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HRD51_00035"
                     /product="hypothetical protein"
                     /protein_id="WP_235091800.1"
                     /transl_table=11
                     /translation="MTGRPRRPLVIYRTADVDAPPATRTEVDWEQLRTVEKGRRSPLAA
                     LRARPGLTGGTARSLARVVRSPP"
     gene            1821..2027
                     /locus_tag="HRD51_RS00045"
                     /old_locus_tag="HRD51_00040"
     CDS             1821..2027
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HRD51_RS00045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HRD51_00040"
                     /product="hypothetical protein"
                     /protein_id="WP_235091801.1"
                     /transl_table=11
                     /translation="MPTLLVDVVERIVVPITALPGPDAGEPCEDTFALEALGRVGALTQ
                     LGPAVSPGTGSISSGWGSSAALR"
     gene            2703..2951
                     /locus_tag="HRD51_RS00050"
                     /old_locus_tag="HRD51_00045"
     CDS             2703..2951
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HRD51_RS00050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HRD51_00045"
                     /product="hypothetical protein"
                     /protein_id="WP_235091802.1"
                     /transl_table=11
                     /translation="MWVLLHRSERSRSLSTWSYPSEQDALHAAAHMAMGWLDDDPSPRT
                     CSPTRRTPRSWHASSNCTPDTDLFEVAELVPMRADQF"
     gene            complement(<3349..3763)
                     /locus_tag="HRD51_RS00055"
                     /pseudo=""
     CDS             complement(<3349..3763)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019057812.1"
                     /locus_tag="HRD51_RS00055"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKTPRPDSTHRDGPPDDGLYVDIRWLLKRQAEVLPETPAHPRLHQ
                     PGGRRRTPPPRQHPQSRRHRRLTLGAPPP"
     misc_feature    complement(4586..4599)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.87"
                     /tool="antismash"
     gene            5852..6190
                     /locus_tag="HRD51_RS00060"
                     /old_locus_tag="HRD51_00050"
     CDS             5852..6190
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HRD51_RS00060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HRD51_00050"
                     /product="hypothetical protein"
                     /protein_id="WP_235091803.1"
                     /transl_table=11
                     /translation="MPLMMMSGGELVAADVRFPVSSLRAVDGHPANDVADSSTADGALH
                     SAQFPGDTKARAGTGDGGGPPCQTASPRLVSCPVRPLAMTVEPVLLAQLTRTFFRETVF
                     LRQPGDEF"
     gene            complement(6147..6488)
                     /locus_tag="HRD51_RS00065"
                     /old_locus_tag="HRD51_00055"
     CDS             complement(6147..6488)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HRD51_RS00065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HRD51_00055"
                     /product="hypothetical protein"
                     /protein_id="WP_235091804.1"
                     /transl_table=11
                     /translation="MPSWSTGDTSRRGDAKELAATAAGGKSLDEAADAIEEINHEIHEI
                     YLEIGISIGISVGMSFVTMGFSAAAGAARAAQLAARAAKLAKTLGTILRKVGEAFKTRL
                     PAGEGTPFP"
     gene            complement(6685..7014)
                     /locus_tag="HRD51_RS00070"
                     /old_locus_tag="HRD51_00060"
     CDS             complement(6685..7014)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091174.1"
                     /locus_tag="HRD51_RS00070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_00060"
                     /product="hypothetical protein"
                     /protein_id="WP_235091805.1"
                     /transl_table=11
                     /translation="MSKGESLVDAAAISRLAKSFDAHGADLESYTKEFRAKTDAEVIDK
                     GFGILTESEEVTSAYIEMSTDMVESLNTLRQHLDHISQGLRTVQQNATASDESLAAGFD
                     QGRHA"
     misc_feature    complement(6967..6969)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(6994..6996)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(7032..7041)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 16.35"
                     /tool="antismash"
     misc_feature    complement(7063..7077)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.33"
                     /tool="antismash"
     gene            7230..7424
                     /locus_tag="HRD51_RS00075"
                     /old_locus_tag="HRD51_00065"
     CDS             7230..7424
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008734335.1"
                     /locus_tag="HRD51_RS00075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_00065"
                     /product="transposase"
                     /protein_id="WP_205371438.1"
                     /transl_table=11
                     /translation="MTTEDATEAGSIEMPESQPSKTVDDQLIDELVGRAQAKGLQLTGE
                     GGLLQQPTKQLPLRRQTMR"
     misc_feature    complement(7263..7277)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     gene            <7744..8253
                     /locus_tag="HRD51_RS00080"
                     /pseudo=""
     CDS             <7744..8253
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971303.1"
                     /locus_tag="HRD51_RS00080"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="phosphotransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="ADAAAYAAAIDMIRRPAPPYEGRACTGTSNPATRCSTCRPQGRQM
                     PGSPASSTGPRPPPDPPDLDVAHCSTHLTLPDVKVVKSFVTQEQDTATNPKAISGGNHT
                     MFLAGNDSDAKKTTTTLLESYGWTDILDLGDLVTARGMEMYAHIHAAISMTLGIANHFG
                     IKITRR"
     gene            8935..9999
                     /locus_tag="HRD51_RS00085"
                     /old_locus_tag="HRD51_00075"
     CDS             8935..9999
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015983.4"
                     /locus_tag="HRD51_RS00085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_00075"
                     /product="radical SAM protein"
                     /protein_id="WP_235091806.1"
                     /sec_met_domain="Fer4_12 (E-value: 8.2e-07, bitscore: 28.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 9.9e-17, bitscore: 60.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQTGDGPRDVIWDITYACPLRCMHCYSESGRRPTRQADRDRMLR
                     ITDAIAALRPGVVSLSGGEPLTVPWIDEVARRLTDSGIKVILYTGGWPVTRAMVERLAE
                     VCHRFVVSLDGPNAEVHDRIRGRAGSFDRALRALELLDEVSRVRREHGLKPLQFGTDCV
                     VVRSNADHLDTFCARIAPRFPELRIVSFQAVIPAGLASRPGFVERELLDEEQVRRLGSE
                     QERARLAALAPPGVLVLTSDNLELRMAPDQVARGLGFEVIQVEPDGEVRAMPVYEGTVG
                     NLLDEPVEVLWRRAVERWADPFVVRTLSAVRTMADWAEAVRLMDHRFGTDADRARFARR
                     PDVQVRPVGLRGGR"
     gene            10001..12757
                     /gene="lanL"
                     /locus_tag="HRD51_RS00090"
                     /old_locus_tag="HRD51_00080"
     CDS             10001..12757
                     /codon_start=1
                     /gene="lanL"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038150.1"
                     /locus_tag="HRD51_RS00090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_00080"
                     /product="class IV lanthionine synthetase LanL"
                     /protein_id="WP_235091807.1"
                     /sec_met_domain="Pkinase (E-value: 3.4e-18, bitscore: 64.8,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.3e-42, bitscore:
                     144.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVRDTVLLDVLTAVLSRAGDGEAGPLGGWRVRAGEFWCYVSPPRE
                     TRQVQGWKLHVSATPLSAPVVLSRAAEVLVRRGCRFKFAGTLERAGELVSRHYERGGGG
                     KFLTVYPEGDEDWLRDLAGELHRATLGLPGPGILSDLPCFPHSLVHYRYGVFSGVTTLD
                     GDGMRAAMLIAPDGALVRDNRRPWFAPPSWAPRDPFAPGRVAEPPKPAPVLLHGRFLVR
                     GVIRHAFAGGVYRAVDQDTGHAVIVKQARRHAAATLAGGDARDMRHHEARMLEGFADSG
                     FTPRPVAVFEQQGDLFLVQEAITGVTLRRWVLDRLVLDDGEEWGPDPDEALATARRLAE
                     AMRAVHHRGWVLRDFNPNNVMVTDDGTLRLIDLETLARPGEHVVRVHTPGYAAAEQVHA
                     GRIDAAPGIESDLYSLGATLFYLATGVDPLLAPGDGGGAHKERLVSWLARLSAGNPAAR
                     RLAPLIGALLDDDPTARPALDEVLHRLRTVDGERARSRPAPVSRGIGEGELKQLITDGL
                     DHLLATMDPGRFDRLWPSGPVGTVSDPFNIQHGAAGVLGVLVLAHRLEPQPALRTAVRS
                     AADWISGLVGREPRCLPGLYYGRSGTAWALLDAAGLLADASLLAHATGLAAGTPVEGPV
                     PDVCHGVAGAGLTQLRFWEATGEPRFLDRARRAAEAVAALAVRRDGLLLWPIPGETLAT
                     SDTLAHYGFAHGVAGVGAFLLAAARATGTAAYAELAVEAARTLLAVVEVEGRCAYWRTG
                     EPGSPRKTHWCSGSSGAGTFLLHAWLETGDEDFLTAARQAAAAVRRTRWHEGPTQCHGL
                     AGDGEFLLDLAQATGDGTYRDWAAELATGIHARHVVRDGRMVVPDDTGTAVWADFNTGL
                     SGVVAFLARLAHGGPRMWVPHSLTAAEPEDPGAGVARAASVPVDDLR"
     gene            12777..12878
                     /locus_tag="HRD51_RS00095"
     CDS             12777..12878
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038157.1"
                     /locus_tag="HRD51_RS00095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ALQxL family class IV lanthipeptide"
                     /protein_id="WP_205367436.1"
                     /transl_table=11
                     /translation="MEFDVNALQVLEQEEPESGAWPEPTKCSCCSTF"
     gene            13138..15309
                     /locus_tag="HRD51_RS00100"
                     /old_locus_tag="HRD51_00085"
     CDS             13138..15309
                     /GO_function="GO:0004181 - metallocarboxypeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012471.4"
                     /locus_tag="HRD51_RS00100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_00085"
                     /product="M14 family zinc carboxypeptidase"
                     /protein_id="WP_235091808.1"
                     /transl_table=11
                     /translation="MLSADQATPRPCYSAVLRPGTPGVSVREVTSPADGVLRARLTPRG
                     GVSGDWDLAVFDKASGTLVDASSGPHSRELAEGTVTRGQRLVVQGCRYAGRARTVSLGV
                     DVVPGQGPTAPARPAAARTTARSALPSGRTTYRQLYEYQYELKELARIHPSLVTSFTLP
                     YPTAEGREVSGVEVAADAPRTADGKPVMLALGLHHASEWPSGEIAMEWAYELVSGYRTD
                     ARIRALVRGTRSVIVPVVNPDGFAVSRAAAPKGDFSRFDYEDKRKNCEAGDSPLEYRTG
                     PCLANPAGRMRGVDLNRNYAGFWGGAGSSPVWDDDHYRGSAPFSEPETRNVRSLVSTRQ
                     VTDLVSLHTYGDLVVRPPGSNDTQPPLDEPAYRALGDRLASHNGYRSEPARELYEATGM
                     TEDWSYWATGGLGLTLEIGPRTAHPPYAEGVVAEYTGTAPAAGAGKGGNRAALLEMLAD
                     TADPAAHATVTGAAPRGYRLRLHKTFRTPTSPVRRPDGSQGPPLEVAETLDSTLLAGGG
                     GFTWSVNPSTRPYVAGRYGREPQAPVQPAVLLSHPPALPPVNTDYPTNPAADRVSFTVE
                     GPPRADNGRMTVSVNWRSRKTEWDLYVLDPAGRTVGESVVGDTDSQQVVMFDPPPGRYT
                     AVVVDFQQADPAAPDAWTGRVDFRSPLPTVHGPTEAYTLTCEDPGGHRLGSTEVTVGRG
                     QRVEVGEVCGAAAGRRAVRVPVRGRTASR"
     gene            complement(15272..15967)
                     /locus_tag="HRD51_RS00105"
                     /old_locus_tag="HRD51_00090"
     CDS             complement(15272..15967)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003953022.1"
                     /locus_tag="HRD51_RS00105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_00090"
                     /product="response regulator transcription factor"
                     /protein_id="WP_235091809.1"
                     /transl_table=11
                     /translation="MPEPMSDRMRVLIAEDHYLVREGTRRLLEDTGEVVVVAAVGTADE
                     LLDAVHRFRPDAVIADIRMPPDHHTEGITAAHAIRAAHPGIGVVVLSQHANEQYAFALF
                     QHGTDGLAYLLKERIGELEELLRALREVAVGRSVIDPRIVEVLVGSLTRTTDAPLSHLT
                     RRELDVLRHMAQGKNNRSIAESLSLSESTIEKHVNSTFAKLGLAEETQLHRRVTAVLTY
                     LRYGPEPAP"
     gene            complement(15960..18008)
                     /locus_tag="HRD51_RS00110"
                     /old_locus_tag="HRD51_00095"
     CDS             complement(15960..18008)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="HRD51_RS00110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_00095"
                     /product="GAF domain-containing sensor histidine kinase"
                     /protein_id="WP_235091810.1"
                     /transl_table=11
                     /translation="MAVENARGMRVLAVCGGLGLLYAVALGVWLTPSRMLPWALGAVVP
                     CYLAGLSLCWKAPGHPVARRVLAAGAWAALGLVVRFTVALLGPLADWVPGPTTSWPLLL
                     LVRTIDVVAAVMIGRLLALLPDGGERYAHERVALRSLWLLVAAPLVLMAVPMPLWLRLR
                     LLVQPEAWMPAVGAGLLLVRSMLDARRPGAQSARWWRTVAAVAFALFAARGSMRLFRMW
                     QGDSGPAYFIGCALGALPYVLISLGLVYVGFRHRLPGLDFTARRSTVYGLLWIIIGGWY
                     LGMVTALGLTASQYLPISTAVLVTVSATMLCQPLRRQANRLAARRVFGARPSNFELLVQ
                     FGTTLEHAYDLTLLAPQLAVSLQEWLDLRWVYVELGTLGPERLPFATGTAGVVPDGADS
                     SRTRVGLCYGDDALGFIEYGPKDEGRFTPEDRDLVETLARQAALAVHNARLNAELSIRI
                     EEVQRQASELNASRTRIVQAQDTERRRIERQLHDGIQQELVALVAKLRLARNQLCRNGD
                     TVYTTLTELQDDAYRVIDGLRELAHGIHPPVLTDQGLAAAVMSRARRLPIPVTVEIEPS
                     VRPARFTPDIEEAAFFLVSEALTNVLKHARAGRVMVRIGRAGGSLLLDVSDDGIGLHST
                     TGPGSGLTGMRDRIEAVGGELSIISRPGDGTTLRARITETRREPTDA"
     gene            18212..20251
                     /locus_tag="HRD51_RS00115"
                     /old_locus_tag="HRD51_00100"
     CDS             18212..20251
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015649.4"
                     /locus_tag="HRD51_RS00115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HRD51_00100"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_235091811.1"
                     /transl_table=11
                     /translation="MTITQTAAPSHQLPDGEEARCTAVAHLLRDRSGTDGRLVAVYQLL
                     GEPERAVAAHRHLASGELHTPAEITATAWAAAAHCARGALRQARALARRTVAALDRCDD
                     PYACVVARTTASAVAAADGRCAAAEHHRQCAQDTARAVGDPLLWLLAVVGTAQQRIERG
                     EPREVLAELDGALGAAGGDAALAVPVVLSGRCRRATALLALGELDRAAAEFTSALTRYH
                     QLGDGVGLALGAQALLGVGDVHRERGELGPARAAYQEAAVLTEQSGDRQTLSSALTGLA
                     VSRGVSEPHSAAVLASRAGQGCAGPPRIRALLAGGWIALAGGRREAAAEAAWQAANEPG
                     AQGCRAVFAELLELEAMCAADSGTRQGLLRDAEAMWSAAQRPMAVARVAVARARLEGAG
                     ATRVREATAWLGQFGVGAGAGEAAGLLNRAAASLRPSASVRVLGGFQVLRDGCSVRAEE
                     WQSKKARDLLKLLVARRGLPTPRELLMEALWPEQDPALCGNRLSVALSILRLVLDPQRR
                     MAQDHFIVADKQVVGLARLHVDVQEFLATARHALGVAERSAEHAFAALTAAEGLYRGDV
                     LADDPYAQWATALREEAQATHAELLARLAAAAAENRDTYAEIHYRLRLLERDPYDEDTH
                     LALVCLLAAAGRHGEARRRYRLYAGYMNEIDVTPAPYPLRTVKD"
     misc_feature    18248..18250
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(21208..21666)
                     /locus_tag="HRD51_RS00120"
                     /old_locus_tag="HRD51_00105"
     CDS             complement(21208..21666)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HRD51_RS00120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HRD51_00105"
                     /product="hypothetical protein"
                     /protein_id="WP_235091812.1"
                     /transl_table=11
                     /translation="MALSASWRGEDITLADVVRLIGLQDTAAEDLQVMVQFQTDSPLGN
                     QAPMSSHLHTVVVNHQVRGMEVARTRLPISRMGTVQRFVADRGSDAVEVRGEQPPGLVE
                     LLGEWHQQQLFEVEFALLVNKDTDLRNWLAVREDTPLGGVRYVLPGCR"
ORIGIN
        1 caggccctcg actggacggg cgacatacgc caccggtaga gtgtcacgat cccgctggtc
       61 tccgctggac ccgcgagtga cttcgggatg gtcgatccgc cggcacccag ccggatcgtt
      121 cgcgtctgtt gggctcgctc gggtgtccaa cactgggcaa tcgactccgt gtcggtcatg
      181 acccgagtct cggggcccgc cgttctgctc gcgctcactt cggcggtggc ctaccggtgc
      241 gatgatccgc taccgattgg gcgctggtgc ctgcgagtgt gcgtgggcga tgtcgccgat
      301 ccacgaagtg gtcagtcttg cccagctcgg gaccgaactg cagcgtcacc cgatattcca
      361 cccgtggctt cgccgtcgcc gccgtctctc gcccccgacc agcgctcacg gtcttcatgg
      421 ccgatggcgc gtatcgaccc gacttccttg acccatcgcc gatgtccagt gagccaacgt
      481 tcgaagaagg catggatgcc tcctcgccgc gcccgcggac cagacgtacg ccgagctggt
      541 cgacgcaacg gaaagggcgc ggggccgaac tgggccgccg actgctcgat gaccccgacc
      601 gagccaggtc cgaggccgcc gatgcgctgc accgcctctt ggaaggcagt tgtagaaccg
      661 gaatggccgt ccatgcgaca ggcgctgcgt gccgagatgc tggatcgagc catccaggtc
      721 aaccgcgagg actgcgcgcc gtcccgcgcc tgcaccctcc gctgcgtgcg aaggcgactc
      781 aatcaccgtc gagaagaccg tcgacatcga cgtcgaccgc cctgaaggac tcattctcgt
      841 accgtcactg ttcatcaccg accggatgca atgcaccacc agaccactgg actccgacga
      901 tctattaccc ggcatccggg cggtacctct gggcggcacc tcctacccga ggtcccttga
      961 ccgtcttctg ggaggactcg atcgaggatc ctggcgccgc gctcaccacc ccgctgcaga
     1021 cgaccgttgc atggccagac tggtgaacgc cactcccccg acagccagcg aacacctggg
     1081 caatcctgcg agacgccggc ttgatcgaca gcagccgggc cggtcgcacg gccacgcacg
     1141 agctcaccac ggctggacgt gccctcatgg ccgccgcccg ccgcggccat gagggcgggg
     1201 agctgctgct ggacagtcaa acgcggcggc gcctacggca accaacccct cggcggcccg
     1261 catgacacct ttcgccgact gcaaccgccg ctgcccgcga agcccgaaca gatgaccggc
     1321 cgtcctcgcc gaccactggt gatctaccga accgccgacg tcgacgcccc gcccgccacg
     1381 cggaccgagg tcgactggga gcagctgcgc acggtcgaga aaggccggcg gtccccgctc
     1441 gccgctctcc gagcccgccc cggcctgacc ggcggcacag cccggtcgct cgccagagtg
     1501 gtccgctcgc ccccatgatg ggcccggctc acccggaccc tcgtgccgcc tgctgacgtt
     1561 ccacccgccg cgccccagcc acccagggag tcgaccaagg cgcggcgctg ctccgggact
     1621 cgaaggagat ctctcccctc ggcaatcgcg tgaggaaggg gtgtcgtttt cgcgtaccgg
     1681 cttcgcccat gggggatggc ctgcggaaat acagtcgatc agtcaggggc atacctccgg
     1741 caacctgcgg cccccctggg tgcaaccgtc cagccaacgg ttcagccgcc tgccggtgca
     1801 accctcttcg ctgaccgtgg atgcccacgc tgctcgtcga cgtcgtcgaa cggatcgtcg
     1861 tcccgatcac cgcgttgccc ggcccggacg cgggcgagcc gtgcgaggac actttcgccc
     1921 tggaggccct cgggcgcgtc ggcgcactga cgcagctggg gccagcggtg tcgccgggga
     1981 ccggctcgat ctcatccggc tggggcagtt cagccgcgct ccgatgacgt ggccgggatc
     2041 atggcacctg tacggacgga agcggcatcg ggcaggaggg ccgagcggtg gggagctggg
     2101 gcaagcaaca ggagcggctc gtggtgcggg ccgtcgacgt gttggcaggc gtgctgagcg
     2161 gagctgcggt ggactcggcg cggcaggtga tcgcgtccag ggtgctgctg gtcatcgagg
     2221 agcaggtgtt ctcgatgtcc gaggagttgg tgctggcgga gggcgtcgag tgccgcggtg
     2281 ccgagcagga tgccgcggtg cggtggtgtg atgcctgcgg gcagtcctgg ctccaggact
     2341 ctggcggctg gttgctcccg ttgccacccg gcgaggagca gatcccgaac accggtcctc
     2401 gcggacggca gccatcccgc catctacgtc caccaccgct cactcggacg aggcgtggcc
     2461 gccagtgttg tggcgtcctg cgcaccatct cctcaagaag ccacggaaac ggaccgccta
     2521 cctggtccct gtcccgctca cggaggcacc gcggtccccg tccgcgcggc cggctgctgc
     2581 gccgcggcct gagcagtccc tgggctacat ctggccggag cagcgggtgg ctgccaacgc
     2641 ctcctggtgt cgcacctgcc agccccctcc gccacgcccc ggtgacgacg gagcccggag
     2701 gcttgtgggt ccttcttcac cgcagcgagc ggagtcgctc gctgagcacc tggtcctacc
     2761 ccagcgagca ggacgccctc cacgccgccg cccacatggc catgggctgg ctcgacgacg
     2821 acccctcgcc caggacctgt tcgccgacca ggcgcacgcc caggtcctgg cacgcttcct
     2881 cgaactgcac ccctgacacc gacctgttcg aggtcgccga actcgtcccg atgcgcgccg
     2941 accagttctg acactgatgg cacaagacgc tccgacaccc gtgcgcgcgg ctggctgggt
     3001 gccgcttccc gatcgccgat ggcgccctcg acaggctcag ggccgcttct cgggcaggtg
     3061 tctatcggcc ttccagatcg tcggcggccc gcgtcgggct gtgcgggacg cggcgcaggg
     3121 cgggcgggaa tccgctgggg gaccttcaac tcggcaggtc tcgccgatcc ggatgtccgg
     3181 ggacacgcat gccggccccc tcccgctcct ccagcctgcc ccgggcggga tagcgcggaa
     3241 gtggtgccga agcacggccg cgagcttcgt ctcagctcgg acggggcccg ctgggggccc
     3301 tcgccagtcc tgcgattccg ggaccgcgcg gtagtggtca gatccgccag aacggatgcg
     3361 atcggccgcg tcgtacgtgt cgcaacggcc ggcgtcgatg tcgcgggcga ggtcgatcag
     3421 cgcgctgtag ggcgcgtcga tgccttgggc cggcggcgcc catgtacgca acgacgaggc
     3481 cggcgccgaa acagggcgtt gcgggcgggc agggggcgca ggcggatgac ggtgtgcatc
     3541 agggtggcgg cgcgccaaga gttagtcgac ggtggcgccg actctgggga tgttgacgcg
     3601 gtggcggcgt cctacggcgg ccaccaggct ggtgaagtcg tggatgtgcg ggtgtttcgg
     3661 ggaggacctc cgcctggcgt ttaaggagcc agcgaatgtc gacgtagagc ccatcgtcag
     3721 gcggcccgtc ccggtgcgtc gagtcgggac ggggcgtctt cagggaaggc ggcgtcgaac
     3781 gcgtcggcgg ggtcgttgac gaaggatgga agacctccgc ggcaccttcg aggcgggggt
     3841 cgcggacggc gtcgtggcgc ggcgcgggcg atgagcgcgg tcaccgtggt gccctcggct
     3901 tcggcgttgc cccttgagca gggcgtggag ctggtcatcg acccggatcg ttactggcct
     3961 tcgacatacg ccgaccgtac agttgggcgc gtacagcacg ggcaggggtt cggcggacct
     4021 cattccgcgg agccccagaa tcaaacttgt gagcgacatt cctccactgc cttccgacct
     4081 ccctgtggct gcacgcaatc gccacatacc tccagccgca gctggagcgc gtacaccagc
     4141 ggatagccga ggtggagcag tgggaggcca cccgacgagc cgcggcgcgc ccgcggtgcc
     4201 accggagtgg acgctgcaga tggacatcgg agcggatctc gcggccgatc gccgtgcacc
     4261 acggccagtg caccatgcgg ggcgcagcgg ggcgccggcg gtcatgtttc gcaggctgtg
     4321 caggtagcgg ggtgcgttgg tggccgatca gcagcaggct gatgaccggg cccgagagcg
     4381 gtgtggttgc cagacaggct cctagcgccg ggggggttcc tgtagctgat gcccgccgta
     4441 atgaggcaga cggacaggaa ggcgatgacg aaggcgatga cgcccggctt gtggaggtgt
     4501 ggctgccaca ggatgtacgg gcccactgcg cgggtcggta tggggctggg gagcggctgc
     4561 gacgggggtg gccgtggggt gcgcctgcat gcgcgtccgg ggcggtccgt cgggtgttgc
     4621 gcccagtagg taccggctgt catcgaggac gaacagggcg ggttccgtcc atcccgactg
     4681 tccgttgggc cgcggcgtcc agtacagcca gccgtggagg ccatacagct cctcggcgag
     4741 cggtacgggg tcgagacagc ggtcgaggaa cagatcccga ctcggccgtc tgacaacgtc
     4801 agacggagcg cggggaaagc tgacggcggc gggtgggttt gctgcgcgcc cggggtaggg
     4861 gaagtggaag cctgcagtgg ccggcgatgc gtacccgcag catgtgcgag cggctccgcg
     4921 atgaggtcgg cgttgaggtg gcgcaggaag tgcccctccc gcaggtcgag cgcggcgagt
     4981 accgcggtga agcagcccca catcgccagg agcacggccc gtacccggag cgatgcggcc
     5041 gctgaggagc gcgtgcagtt cgccccggct cgggcctgtg atggtgccgg gcgccgcgcc
     5101 ggcggaggag tgcagggccc agaccctgtc gccctttgtt gagcgggtgg ccggtggtga
     5161 tgctctccgt cgtcaggtgt gtgccccgtg ggccatccgg aaggggccac ggagaccgtg
     5221 gaggtgtact cggtgaagtt ccgcgactgg ttgtggctgg tggagtggat ctcctgggat
     5281 tggtgacgcg gacaggaccg gtcctccgcg gacgatcgct gccagttcgg gggtggtggc
     5341 tgccgccgaa gtcatcagca ggagcagcgg catgaccagg accgtgagcg cgagggcgac
     5401 catgccgccg cgccgtcccg gccaccaccg cgtgcccggc cccgcctttt tcaagctggc
     5461 cccggcgggc cgctgcgcca tgcgccacca cgccacggtg gccgcgcgcc ggagaccgcc
     5521 agacaggcca gcagatccca gcgcggatag ggcgccacct tccgcaccag agacacacaa
     5581 acgcggcgac acccgcccag gccacagccc ggcggacgcc gccgcgcgat cccgttcctc
     5641 acccgaaaac gtccctcacg ctcttcttgc ccgggtcacc tggcgcgacg tccctctgat
     5701 tcttccttgg cgccggtcac gcacttcagg gccccgcccc ccaccgccag acccgttgat
     5761 gatgccgtcg accgagaagt gtggcccctc acggccgggt gggagatggg tgttggcgcc
     5821 atgtacgact gcgccgctgg cgcctcctgt gatgccgttg atgatgatgt ccggcggcga
     5881 actcgttgcc gctgacgtcc ggttcccggt gagcagtctt cgcgccgtcg acggccatcc
     5941 cgccaacgat gttgccgaca gctccaccgc ggatggcgcc cttcattccg cccagtttcc
     6001 cggcgacacc aaggcccggg ccggtaccgg cgacggcgga ggcccgccct gccagacggc
     6061 ttcgccgagg ttggtgtctt gtccggtcag gccgttggcc atgaccgtgg agccggtgtt
     6121 gctggcccag ttgaccagaa cgttcttcag ggaaacggtg ttccttcgcc agccgggaga
     6181 cgagttttga aagcctcgcc gaccttgcgc aagatggtgc cgagagtctt ggcgagtttg
     6241 gcggcgcggg cggcgagctg ggcggcgcgg gcggcccccg cggctgccga gaagcccatg
     6301 gtcacaaagg acatgccgac cgatattccg atggagatgc cgatctccag atagatctcg
     6361 tggatctcgt ggttgatctc ctcgatggcg tccgcggcct cgtcgaggct tttgccgcct
     6421 gcggcagttg cggcaagctc ttttgcatcg ccgcgtcggg aggtgtctcc agtgctccac
     6481 gaaggcatcc gccgccggac cgtgccagcc ggactccagg gtccgctgca cctcgtggtc
     6541 caggtcccgg aacatggtct ggaggttttc gtggagatcc cgccagcccc tttgctgccg
     6601 tgcgcagggc gtccggatca ccgccggggt tgatgatgtc caggccggcc tcgtagacct
     6661 cttccgctac cgactcgtcg ccgctcacgc gtgacgcccc tggtcaaagc ctgccgccag
     6721 agactcgtcc gacgctgtgg cgttctgctg gaccgtgcgc aggccctggc tgatgtgatc
     6781 gaggtgctgg cgcagggtgt tcagcgattc caccatgtcg gtggacatct cgatgtacgc
     6841 ggaggttact tcctcggatt ccgtgaggat gccgaatcct ttgtcaatca cctcagcgtc
     6901 ggtcttcgcc cggaactcct tcgtgtagct ctccaggtcc gccccatgag catcaaagct
     6961 tttcgctaac cgggagatgg ctgccgcatc cactaacgac tcgcccttag acatgactca
     7021 ctcctcatcg ctcacaaaac atacctgcgg catttcaatc aagattttcc gcaactaatg
     7081 aatcctagag aagaatgatc accgaagtga gatccaaacg atcccttgtc gcacccttag
     7141 tgaatccctt acgccccctg gtgggtgcga cgtgacagtc cgggacggta aaccgttcga
     7201 tgcaactccc agtcaaggaa gatgcactga tgaccactga ggacgcgacc gaggcagggt
     7261 ccatcgagat gcctgagtcg cagccgtcga agacggtgga cgaccaactc atcgacgaac
     7321 tggtgggccg ggcacaggcc aagggactac aactgacagg cgagggcggg ttgctacagc
     7381 agccgaccaa gcaactgccg ctgcgccgtc agaccatgcg gtgatgcagc tcatgagacg
     7441 cggactgcct cacccggttc gcccgtgacc aacgcgggac gatttcaagg gcgaacagca
     7501 ctcgcaagcc gtcagcggag cattccgtgc agcaggcgtt ccagcgccca ggcgaagtct
     7561 gctccacggt ccactcctcg accgtggagc tcttctcccc ggcaggctgg ccttaccatg
     7621 gtcgaccgta tgccccacac tgggtgagcg ttaagcaggt acccgagcat catgttccac
     7681 atcgcgcgat aggctcgcgc cccatccggc cgttccagcc cgagggcttc cagtcctcgc
     7741 atcgccgacg cggcggcata cgccgcggca atcgacatga tccgcaggcc cgcgccgcct
     7801 tatgaggggc gggcctgcac cgggacttcc aacccggcaa cgcgttgttc gacgtgccgc
     7861 ccgcaaggcc ggcagatgcc cggatcaccg gcgtcgtcaa ctgggccgcg acctcctccg
     7921 gacccgcccg atctcgacgt ggcgcactgc tccacccatc tcacgctgcc ggacgtgaag
     7981 gtcgtcaagt ccttcgtcac ccaggaacag gacaccgcca ccaaccccaa ggccatcagc
     8041 ggcggcaacc acaccatgtt cctcgccggc aacgactccg acgcgaagaa gaccaccacc
     8101 accctgctgg aatcctacgg ctggaccgac atcctcgacc tcggcgacct cgtcaccgcc
     8161 cgcggcatgg agatgtacgc ccacatacac gccgccatca gcatgaccct cggcatcgcc
     8221 aaccacttcg gcatcaagat cacccgccga taaccccctc cagcgccaag cccaagccag
     8281 cgacggcctg gacctggcgc caaccactgc atccccacac caccgcgccc aagacagaag
     8341 caaagacaac agctaccaag acagcactcc cgccagaaca ccgacacaca cttggccaag
     8401 caaaccgacg gccctcgata ccgtggccga cgtcgctctc gcctatggca cgcaagccac
     8461 cccgttcctg cccgtcggag aacttgaccg acgcctgcgt gccgtcatcg ccgaccgttt
     8521 cgacctggcc gacgtcacgg ccgtgtgcga ccgcgacggc tcccgccgcc tgacctcgtt
     8581 cgaccggctc accttcggcg gctacctgag cgtactgggc aaccgtgagc cgtgggagga
     8641 gttgggctgg ctactggatc gcggggcctt cgccaagcgc ctcgatgaga tccgcaaaat
     8701 ccgcaacaat ctgatgcacc tcaccccgac tcgctcccac acgataccga ggccaaggtc
     8761 cgcggtgtca tcgcggcgtt caggacgagg acctgacggt ccgctggctt ccgctcccgt
     8821 ccccgccccg ttcggccacc gacgaccgca agacgggact aaggccaccg acagggcccc
     8881 ggccaggatg gcgccaaggc aggaacggcg acgtcggagg cgacgatggg tcgaatggca
     8941 cagaccggtg acggtcccag ggacgtcatc tgggacatca cctacgcgtg ccctctgcga
     9001 tgtatgcact gctactccga gtcaggtcgg cgccccaccc ggcaggcgga ccgtgaccgg
     9061 atgctgcgca tcaccgacgc gatcgccgcg ctgcgccccg gcgtggtgtc gctcagcggt
     9121 ggggagccgc tgacggtgcc ctggatcgac gaggtcgccc ggcggctcac cgacagcggc
     9181 atcaaggtga tcctctacac ggggggctgg ccggtcaccc gggccatggt ggagcgactc
     9241 gcggaagtgt gccaccgctt cgtggtcagt ctggacgggc cgaacgccga ggtgcacgac
     9301 cggatccggg gcagggcggg ttcattcgac cgggccctgc gcgcgttgga gttgctggac
     9361 gaggtctccc gtgtgcgccg cgaacacggt ctgaaaccac ttcagttcgg taccgactgt
     9421 gtcgtggtgc gcagcaacgc cgatcacctg gacacgttct gtgcccggat cgccccgcgt
     9481 ttccccgagt tgcggatcgt gtcgttccag gcggtgatcc ctgccgggct cgccagtcgg
     9541 cccggattcg tcgagcggga gctgctggac gaggagcagg tgcgccggct gggcagtgag
     9601 caggagcggg cgcgtcttgc cgctcttgca ccaccgggcg ttttggtgct cacttcggac
     9661 aacctggagc tgcggatggc tcccgaccag gtggcgcggg ggctgggctt tgaggtcatc
     9721 caggtggagc cggacggcga ggtacgggct atgccggtgt acgaggggac ggtcggcaat
     9781 ctcctcgacg aaccggtgga ggtgctctgg cggcgggctg tggagaggtg ggccgacccg
     9841 ttcgtggtcc gcacgctgtc ggcggtccgc accatggctg actgggcgga ggcggtgcgg
     9901 ctcatggacc accggttcgg cacggatgct gatcgcgccc ggttcgctcg tcgccccgat
     9961 gtgcaggtcc gtcctgtcgg cttgagggga gggaggtgac atggtccgcg acacggtgct
    10021 gctcgatgtc ctcacggcgg tgctctcccg cgccggggac ggtgaggcgg gtccactggg
    10081 cggatggcgg gtacgggccg gggagttctg gtgttacgtc tccccgcccc gcgagacacg
    10141 gcaggtgcag ggctggaagc tacacgtttc ggcgacgccg ctgtcggccc ccgtcgtact
    10201 gtcgcgcgcc gccgaggtac tggtacgtcg cggctgccgg ttcaagttcg ccgggactct
    10261 tgagcgtgcg ggcgaactgg tttcgcggca ctacgagcgg ggcggcggtg ggaagttcct
    10321 caccgtctac ccggaagggg acgaggactg gctgcgagac ctggccggtg agctgcaccg
    10381 ggcaaccctg gggctccccg ggcctggcat cctgtccgac cttccgtgct tcccgcacag
    10441 ccttgtgcac tatcggtacg gcgtcttcag cggggtcacc acgctggacg gcgacgggat
    10501 gcgtgctgcg atgctgatcg ccccggacgg ggcgctcgtc cgtgacaacc gtcggccttg
    10561 gttcgctccg ccgtcgtggg ctccgcgcga tccgttcgcg cccgggcggg tcgccgaacc
    10621 gccgaagccc gcgccggtgt tgctccatgg gcggttcctc gtgcgcgggg tgatccggca
    10681 cgccttcgcc ggtggtgtct accgggctgt ggaccaggac accgggcatg cggtcatcgt
    10741 caagcaggcg cgtcgtcatg cggcagccac actggccggg ggtgacgcac gcgatatgcg
    10801 gcaccacgag gcgaggatgc tggagggttt cgccgacagc ggcttcaccc cgcgcccggt
    10861 ggcggtgttc gagcagcagg gtgacctgtt cctggttcag gaggccatca ccggtgtcac
    10921 gttgcgccgt tgggtgctcg accggctggt cctcgacgac ggcgaggagt gggggcccga
    10981 ccccgacgag gccctcgcca cggctcgccg gctggccgag gcgatgcgtg cggtgcacca
    11041 caggggctgg gtcctgcggg acttcaaccc caacaacgtg atggtcaccg acgacggcac
    11101 cctgcggctg atcgacctgg agacgctcgc ccgtccgggg gagcacgttg tgcgcgtgca
    11161 cacccccggg tacgcggcgg ccgagcaggt gcacgcgggg cgcatcgatg ccgcaccggg
    11221 gatcgagtcc gacttgtaca gcctgggcgc caccctgttc tatctggcca ccggagtcga
    11281 cccgctgctt gccccgggtg acggcggcgg tgcgcacaag gagcggctgg tctcctggct
    11341 ggcacggctg tcggcgggca acccggccgc gcggcgcctc gctccgctca tcggggcgtt
    11401 gctggacgat gaccccacgg cgcggcccgc cctggacgag gtgctgcacc ggttgcgcac
    11461 ggtggacggt gaacgggctc ggtcccgtcc ggctccggtg tcacggggta tcggggaggg
    11521 cgaactcaag cagctcatca cggacggtct cgaccatctg ctcgccacca tggacccagg
    11581 gcgctttgac cggctgtggc cctccggccc cgtcggcacc gtgtcggatc cgttcaacat
    11641 ccagcacggc gccgccggag tgctcggggt cctggtcctg gcccatcggc tcgaaccgca
    11701 gccggccctg cgtacggcgg tgcgctcggc ggcggactgg atcagcgggc tggtggggcg
    11761 cgaaccgcgc tgtctgccgg ggctgtacta cgggcggtcg ggtaccgcct gggcgctgct
    11821 ggacgcggca gggctgctgg cggacgcgtc actgctggcg cacgccacgg ggctggcggc
    11881 ggggacaccg gtggagggtc cggtgcccga tgtctgccac ggtgtggcgg gggccgggct
    11941 gacccagctg cgattctggg aggctactgg agagccgcgg ttcctggacc gggcgcggcg
    12001 ggcggccgag gcggtggcgg cgttggcggt gcgcagggat ggtctgctgc tgtggccgat
    12061 tcccggggag acgctggcga cctccgacac tctcgctcac tacgggttcg cgcacggcgt
    12121 ggcgggggtc ggcgccttcc tcctggcggc tgcgcgggcc accggtacgg ccgcgtacgc
    12181 cgagctcgcc gtcgaggccg cccggacgct gctcgccgtg gtcgaggtgg aaggcaggtg
    12241 cgcgtactgg cggaccgggg aaccgggcag cccgcgcaag acccactggt gcagcggctc
    12301 ctcgggggcg ggcacgttcc tgttgcacgc ctggctggag accggcgacg aagattttct
    12361 gacggcggcc cggcaggcgg ccgcggccgt gcgccgtacc cgctggcacg aggggcccac
    12421 ccagtgccac ggtctggccg gggacggcga gttcctgctc gacctcgctc aggccaccgg
    12481 tgacggcacg tatcgggact gggccgcgga gctcgcgacg ggcatccatg cccgccatgt
    12541 cgtacgggac gggcgcatgg tcgtccccga cgacaccggc acggccgtgt gggccgactt
    12601 caacaccggg ctttccggag tggtcgcctt cctggcacgc ctcgcgcacg gcggcccgcg
    12661 gatgtgggta ccgcactcgc tgacggcagc ggaacccgag gaccccggtg cgggggtggc
    12721 gcgagccgcc tcggtaccgg ttgacgacct gcgatgacga aaggaggtga atggcaatgg
    12781 agttcgacgt gaacgccctc caggttctgg agcaggagga gcccgagagc ggcgcctggc
    12841 ccgagccgac gaagtgctcg tgctgcagca ccttctgacg gctgcggccg gcaaccaggt
    12901 caccgccttc gctctgacga gggcggtgac cgaccgaggc aaccgacacg accgaccgga
    12961 cgcaggggaa gggaagatca tgcgcgcact gcggggccgt ggcggagcac tgcggacggt
    13021 cctggccgtc gtcccggtgg gggtcgtcgt cctggccggt ctgccggcac cggccttggc
    13081 gccggcggcg acggcgacgg ccatggcgag ggtgggcccc tccccatcga ccggaccgtg
    13141 ctctccgccg accaggcgac gccccggccc tgttactcgg ccgtgctgcg cccggggact
    13201 ccgggcgtct cggtgcgcga ggtcacctcg ccggcggacg gtgttctgcg ggcgcggctg
    13261 acaccacggg gcggcgtgag tggagactgg gatctggccg tgttcgacaa ggccagcgga
    13321 accctggtcg acgcctcctc cgggccgcac agccgggagt tggccgaggg caccgtcacc
    13381 cgggggcagc ggctggtggt gcagggctgc cgctatgccg gacgggcccg gacagtgtcg
    13441 ctgggtgtcg atgtcgtgcc cgggcaggga cccaccgccc ccgctcgccc tgccgccgcc
    13501 cggacgacgg cacgctccgc gcttccctcc ggccgtacca cgtaccggca actgtacgag
    13561 taccagtacg agttgaagga actggcccgc atccatccgt cccttgtcac ctcgttcacc
    13621 ctgccctacc ccaccgctga ggggcgggag gtgtccgggg tggaggtggc tgcggacgcg
    13681 ccccggaccg cggacggcaa gccggtgatg ctggccctgg gtctgcatca cgcctccgag
    13741 tggcccagcg gggagatcgc catggagtgg gcgtacgagc tggtctccgg ctaccgcacc
    13801 gatgcccgga tccgtgcgct ggtgcgcggg acccgaagcg tcattgtgcc ggtggtcaat
    13861 cccgacggct tcgccgtctc ccgcgcagcg gcgcccaagg gtgacttctc ccgcttcgac
    13921 tacgaggaca agcgcaagaa ctgcgaagcc ggggactcgc cgctggagta ccgcacaggg
    13981 ccgtgcctcg ccaatccggc cggccggatg cgcggtgtgg acctcaaccg caactatgcg
    14041 ggcttctggg gtggagccgg ctcctcacct gtgtgggacg acgatcacta ccgcggctcg
    14101 gcgcccttct cggagcccga gacccgtaat gtgcggtccc tcgtctccac ccgtcaggtc
    14161 accgacctgg tgagcctgca cacctatggg gacctcgtgg tgcgcccgcc gggttccaac
    14221 gacacccagc cgccgctgga cgagccggcg taccgggccc tgggtgaccg gctcgcctcg
    14281 cacaacggct accgcagtga accggctcgg gagttgtacg aggctaccgg gatgacggag
    14341 gactggtcgt actgggccac cggagggctt ggtctgaccc tggagatcgg cccgcggacg
    14401 gctcatcctc cctacgcgga gggggtggtg gccgagtaca ccggtacggc gccggcggcc
    14461 ggggcgggca agggcggcaa ccgggcggcg ctgctggaga tgctcgccga caccgccgac
    14521 cctgcggcgc acgccacggt gacgggtgcg gcgccgcgcg gttaccggct gcggctgcac
    14581 aagacgttcc ggacccccac ctcaccggtc cggcggccgg acggttcaca ggggccgccg
    14641 cttgaggtgg ccgagacgct cgattcgacg ctgctcgccg ggggcggtgg gttcacctgg
    14701 tcggtcaacc cctccacccg gccctacgtg gccgggcggt acggaaggga gccgcaggcg
    14761 ccggtccagc cggcggtcct ccttagccac ccgcccgccc tgccaccggt gaacaccgac
    14821 taccccacga atccggcagc ggaccgggtc tcgttcaccg tcgagggacc gcctcgggcc
    14881 gacaacggca gaatgaccgt gtcggtcaac tggcggtcgc ggaagaccga atgggacctt
    14941 tacgtcctgg acccggcggg gaggacggtg ggcgagtcgg tggtgggcga caccgactcc
    15001 cagcaggtcg tcatgttcga cccgccgccc ggccggtaca ccgccgtggt ggtcgacttc
    15061 cagcaggccg accccgcggc cccggacgcc tggacgggcc gtgtcgactt ccggtcgccg
    15121 ctgccaaccg tccatggccc caccgaggcg tacaccctga cctgtgagga cccgggtggt
    15181 caccggttgg ggagcaccga ggtcaccgtc ggccggggac agcgagtcga ggtgggagag
    15241 gtgtgcgggg cggcggccgg caggcgggcg gtcagggtgc cggttcgggg ccgtaccgca
    15301 agtaggtgag caccgctgtg acgcggcggt gcagctgggt ctcctcggcg aggcccagct
    15361 tggcgaaggt ggagttgacg tgcttctcga tggtcgactc cgacagggac agggactccg
    15421 cgatggaccg gttgttcttg ccctgggcca tgtgccgcag tacatcgagc tctcggcgtg
    15481 tcagatggga cagcggcgcg tccgtggtgc gggtgaggct gcccaccaag acctccacga
    15541 tgcgcgggtc gatcacggaa cgcccgacgg cgacctcccg cagggcccgc agcagttcct
    15601 caagctcgcc gatgcgttcc ttgaggaggt aggccagccc gtcggtgccg tgctggaaca
    15661 gcgcgaaggc gtactgctcg ttggcgtgct gcgacagtac gaccacaccg atgccggggt
    15721 gcgcggcgcg gatggcgtgt gcggcggtga tgccctcggt gtggtggtcg ggcggcatcc
    15781 ggatgtcggc gatcacggcg tcggggcgga accggtgcac cgcgtccagc agttcgtccg
    15841 ccgtgccgac ggccgcgacc acgaccactt cgccggtgtc ttccaacaga cggcgggtac
    15901 cctcgcgcac caggtagtgg tcctcggcga tgaggacgcg catcctgtcg gacatcggtt
    15961 caggcatcgg tgggctcccg tcgtgtctcg gtgatgcgcg cgcgcaaagt ggtcccgtca
    16021 ccgggccggc tgatgatgga cagttcgccc ccgacggcct cgatccggtc ccgcatcccg
    16081 gtcagtcccg agccgggccc ggtcgtcgag tgcagcccga tcccgtcgtc gctgacgtcg
    16141 agcagcagcg agccgccggc acgcccgatc cgcaccatca cgcggcccgc ccgggcgtgc
    16201 ttgaggacgt tggtgagtgc ctccgacacc aagaagaacg ccgcctcctc gatgtcgggc
    16261 gtgaagcgcg ccggacgcac ggacggctcg atctcgacgg tcaccgggat cggcagcctg
    16321 cgggcccggg acatcacggc cgccgcgagg ccctggtcgg tcagcacggg tggatggatg
    16381 ccgtgggcga gctcgcgcag cccgtcgatg acccggtagg cgtcgtcctg gagctcggtg
    16441 agggtggtgt acaccgtgtc gccgttgcgg cagagctggt tgcgggcgag ccgtagcttc
    16501 gccacgagcg cgacgagttc ctgctggatt ccgtcgtgga gctggcgctc gatcctgcgc
    16561 ctctcggtgt cctgggcctg cacgatgcgc gtgcgggagg cgttgagctc gctggcctgc
    16621 cgctgcactt cctcgatgcg gatggacagt tcggcgttga gccgtgcgtt gtgcaccgcg
    16681 agcgccgcct gtcgggcgag ggtctcgacg aggtcacggt cctcgggggt gaaccgtccc
    16741 tcgtccttgg gtccgtactc gatgaagccg agggcgtcgt cgccgtagca gagccctacc
    16801 ctggtccgtg acgagtccgc cccgtcgggc accacgcccg ccgtccctgt ggcaaagggg
    16861 agccgctccg gcccgagggt gcccaactcg acatacaccc aacgcagatc cagccactct
    16921 tgcagactga cggcgagctg cggcgccagc agcgtcagat cgtaggcgtg ctcaagggtc
    16981 gtaccgaact gcaccagcag ttcgaagttg gagggccgcg ccccgaacac ccgtcgcgcg
    17041 gccagccggt tggcctgtcg gcggaggggc tgacacagca tggtcgcgct gacggtcacc
    17101 aggaccgccg tgctgatggg caggtactgg ctcgcggtga gcccgagggc ggtgaccatg
    17161 cccaggtacc acccgccgat gatgatccag agcagtccgt agacggtgga gcgccgggcg
    17221 gtgaagtcca gccccggcag ccggtgccgg aaccccacat acaccagacc caacgagatc
    17281 agaacgtagg gcaacgcgcc cagggcgcag ccaatgaaat atgcaggccc gctgtctccc
    17341 tgccacatcc ggaacaacct catggagcct cgtgcggcga acagggcgaa ggccactgcc
    17401 gcgaccgttc gccaccagcg cgcgctctgg gcgcccgggc gtcgtgcgtc cagcatcgac
    17461 cgcaccagca acaggcccgc ccccaccgcg ggcatccatg cctctggctg gaccagcaag
    17521 cgcagccgca accacagggg catcggcacc gccatcagca cgagcggagc cgcgaccagc
    17581 agccacaacg accgcagcgc gacgcgttcg tgggcgtagc gctcgccgcc gtccggcagc
    17641 agggcgagta gccggccgat catgacggcc gccaccacgt cgatcgtccg gaccagcaac
    17701 agcagcggcc aactggtggt cggtcccgga acccagtcgg caagagggcc caggagcgct
    17761 acggtgaacc gcaccaccag ccccagggcc gcccacgccc cggccgccag cacccgccgc
    17821 gcgaccggat gtcccggggc cttccagcac aatgacagcc ctgccagata acacggcact
    17881 actgcgccca gagcccaggg gagcatccgc gagggcgtga gccagacccc gagcgcaaca
    17941 gcgtagagca gccccagtcc accgcagacc gccaggacac gcatgccccg tgcgttctca
    18001 accgccatgg ggcaagtgtc gcttgaccgt ttttccctgt acagcacgca tgcctccccc
    18061 cgggatggcg gagaacctcc atacaggaac agaaggcgcc cggattcgcc gcccgcgcgc
    18121 cgccgagcac actcgtcgcg gggcgatccg gtggtcccgg atcgcagtga gtgtggaagc
    18181 gccgcgcgac ggacggcacg gaggggcggg gatgaccatc acacagacgg cagcaccgag
    18241 tcaccagtta cccgatggcg aggaagcacg atgtacggcg gtcgcacacc tgttgcgcga
    18301 ccggtccggc acggacggcc ggctggtcgc ggtctaccaa ctgctgggcg aaccggaacg
    18361 ggcagtcgcc gcccaccggc acctggcctc cggcgagttg cacacgcccg cggagatcac
    18421 ggcgacggcc tgggccgcag ccgcccactg cgcccggggg gcgctgcggc aggcccgggc
    18481 cctcgcccgg cgcaccgtgg ccgcgctgga ccgctgcgac gatccgtacg cctgcgtggt
    18541 ggcccgcacc acggcctcgg ccgtggcggc cgcggatggc cgttgtgcgg ccgccgagca
    18601 ccaccggcaa tgcgcgcagg acaccgcccg tgcggtgggc gatcccctgt tgtggctgct
    18661 ggcggtggtg ggcacggcgc agcagcggat cgagcgggga gagccccgag aggtgcttgc
    18721 cgaactggac ggcgcactgg gtgcggctgg cggggacgca gccctcgcgg tccctgtggt
    18781 gctgtcgggg cggtgccgcc gggccaccgc gctgctggca ctcggtgaac tcgaccgggc
    18841 cgcagccgag ttcaccagtg cgctcacgcg gtatcaccag ctgggggacg gcgtgggcct
    18901 ggcgctggga gcacaggcgc tgctcggtgt cggcgatgtc caccgggagc gtggtgagct
    18961 ggggccggcc cgggcggcgt accaggaggc agcggtcctc accgagcaat ccggcgaccg
    19021 tcagactctg tcctcggctc tgaccggcct cgcggtgtcc cggggggtca gcgaacccca
    19081 ttcggcggca gttctggcgt cccgggccgg gcaggggtgc gccggtccgc cgcgaatccg
    19141 cgccctgctg gcgggcggct ggatcgccct ggcgggcggg cgccgcgagg cggccgccga
    19201 ggcggcctgg caggcggcca acgagccggg cgcgcagggg tgccgagccg tcttcgccga
    19261 actgctggag ctggaggcca tgtgtgccgc cgactctggt acgcggcaag ggttgttgcg
    19321 ggacgccgag gcgatgtggt ccgctgcgca acgaccgatg gccgtggcca gggtcgccgt
    19381 cgcacgggca cgacttgagg gtgccggcgc gacgcgggtg cgtgaggcca ccgcctggct
    19441 gggccagttc ggggtgggcg ccggggccgg ggaggctgcg gggctgctca accgggcggc
    19501 ggcgagccta cgcccatcgg cgagcgtgcg ggtgctgggc ggcttccagg tcctccggga
    19561 cggctgctcg gtccgggccg aggagtggca gtcgaagaag gcacgggacc tgctcaagct
    19621 cctggtggcc agacgaggac tgcccacacc gcgtgaactg ctgatggagg ccttgtggcc
    19681 cgaacaggat ccggccctgt gcggaaaccg gctgtcggtg gcactgtcca tcctccgcct
    19741 ggtactggat ccacagcgcc gcatggcaca ggaccacttc atcgtcgcgg acaagcaggt
    19801 ggtgggcctg gcccggctgc acgtggacgt gcaggagttc ctggccaccg cacgccatgc
    19861 gctgggagtg gccgagcggt cggccgagca cgccttcgcg gcgctgaccg ccgccgaggg
    19921 cctgtaccgc ggcgacgtct tggcggacga cccttatgcg cagtgggcca cggctctgcg
    19981 ggaggaggcc caggcgaccc atgcggaact gctcgccagg ctcgctgcgg cggctgccga
    20041 gaaccgtgac acctacgcgg agatccacta caggcttcga ctgctggaac gcgatccgta
    20101 cgacgaggac acccacctcg ccctggtctg cctgctggca gcggccggcc gccatggcga
    20161 agcgcggcgc cgctaccggc tgtacgccgg gtacatgaac gaaatcgacg tcaccccagc
    20221 gccctatccc ctccggacag tcaaggactg atcaggcatg ggtccatacc accacggcaa
    20281 gatcaatgtc agagtcaggc agggacacca gatgaaaggg cagcactctc tggccgggca
    20341 acgccccgga accggaaccc ggcggtgggt cggcgacagc cggttcgggg cagcgcaacg
    20401 gccggcgcag tcaaaggaac cggggcggcc cgccacgcac cggccatctc ctcggccagc
    20461 agccggtgtt cggcgtgcac gtccaggacc tgaagccggg ctcgccaagc ccggacgaca
    20521 acggtccgcg gccgcacagc ggccaggcga cgcggccacg gccgacggca ggcggcggac
    20581 tcggcgacac ggcggcgccg agcgtcgcgg cgacgacagg ccgccggacg ccggcggggc
    20641 cctggggcgc gaccgggtcc gtggccgtta gacggacggc agcggaccca cagggatcca
    20701 cgggcgggcc ggcgcacggg gcccgacgac gcccgacgac ggcggagcag cagagtccgg
    20761 ccggcaggac gacagcgaag cgagcaaccg tggcccaagc cggcggggca tccgcggtga
    20821 ggtgccggcg tcgcccgacg gggagggtga agctgtcggg gacgacggcg tcgatcagcg
    20881 tcttgccggc aaggttgccc tcacccgcgg cttgcacggc ctggagtgtg gtgtggccgg
    20941 cagtggcgtt gatccgcaac tcggcgtcct cggctacgtc ggcgaagcgt gccaggcgta
    21001 tgccggggtg ctgctccagc cagggcgcgg ccgctggggt gcggctccgc ccgcgcggct
    21061 ggggtggctg tttaccaggt ctggcgctgg gtgacaccga tgacgaaccc tgggggtcgg
    21121 tgaagtggaa gagctttgtc cgtgggactc gaaggcgtcc ttggcgacct tcatcagcgg
    21181 gcggaccttt ccgcgtaggc gtcgaagtca tcgacagcca ggtagaacat accgaacacc
    21241 ccccaacggg gtgtcttccc gcaccgccag ccagttccgc aggtcggtgt ccttgttgac
    21301 caggagagcg aactcgacct cgaacaactg ctgttgatgc cactccccga ggagctcgac
    21361 gagaccgggc ggctgttcac cccgcacctc aaccgcgtcc gaaccccggt ccgcaacgaa
    21421 ccgctgcacc gtccccatcc ggctgatcgg caagcgggtc cgagccacct ccatgcctct
    21481 cacctggtgg tttacgacca cagtgtggag gtggctcgac atgggcgcct gattgccaag
    21541 ggggctgtcc gtctggaact gaaccattac ctggaggtcc tcggccgctg tgtcctggag
    21601 gccgatgagg cggacgacgt cggcgagcgt gatgtcctcg ccgcgccagg acgcgctcag
    21661 ggccaatccc tgatccttgg cgtaccaggc tctggccgcg agggacagcg acaggtcgtc
    21721 cagcccgcgt acggtgaaga accgtaggcg tcgaacactc cggcctccgg tgctggcaag
    21781 gagagcccag aggccgtccg gatgatgagg tggcacggtg accgaccacg atgaggcggc
    21841 gactgtccga ccgttgaccc tggcttgggt gagtcggcac ctcaaggccg gcgaacggat
    21901 cgtcaggacc gaggcgctgc gcgggggcat cactgccgaa atgcggcggc tgaccatcgg
    21961 cacgcgggac ggacgcaccc gtgacctggt gctgcggagc ttcgtcgacc cgttctacgt
    22021 ggagcacgcc gcggactggc tgaacaggga ggccggcgcc ctgccgctgc tggcggggac
    22081 cggcgtgccg gctcctgaac tggtcgcggt tgatccgacc gccgcgcagt gcgagcatcc
    22141 atcgctcctg atgacacatc tggtgggccg gacggtcctc gacgacgagg cagtggagac
    22201 gcgcattccg ctgctggccc gtcaactcgt ggcgatccac gcgatgcgcc ccgccgaacg
    22261 gccccgggag tatgtggcgt tgacgaccgc cgacaccgtc gtggttccca agggcgccga
    22321 cgaggcggca tgggccgccg cgatcgacgt gatccgcaac cccgcgccac cctatgaagg
    22381 gcggttcctg caccgggact tccaacccgg caacgtgctg ttcgacgtgc cgcccgcaag
    22441 gccgacgggt gcccggatca ccggcgtcgt cgactgggcc gcgacctcct ggggcccctc
    22501 tgatctcgat gtggcgcact gctccaccaa tctcgcgctg ctgcacggcc cggcgtgggg
    22561 tctgcggttc gccgaggcat atgaggaggc cggcgggatg ctcgccgagg ccgcgagcga
    22621 gcgactgtac tggcaggtgc gggacgggtt ggcgtgctca gaagaagtgc agcaggtgac
    22681 gcagccatgg cgagaggcgg ggaggacaga gctgacgaca cgagccgtgg aagagcggct
    22741 ggatgcctac gtcaccg
//
