LOCUS       NZ_CP090412            25967 bp    DNA     circular CON 31-MAR-2024
DEFINITION  Ligilactobacillus salivarius strain 2102-15 plasmid pLS2102-15_1,
            complete sequence.
ACCESSION   NZ_CP090412
VERSION     NZ_CP090412.1
KEYWORDS    RefSeq.
SOURCE      Ligilactobacillus salivarius
  ORGANISM  Ligilactobacillus salivarius
            Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
            Ligilactobacillus.
REFERENCE   1  (bases 1 to 140826)
  AUTHORS   Karlyshev,A.V.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JAN-2022) Biomolecular Sciences, Kingston University
            London, United Kingdom, Penrhyn Road, Kingston upon Thames KT1 2EE,
            United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: OCT-2021
            Assembly Method                   :: Unicycler v. 0.4.0
            Assembly Name                     :: sequence.fsa
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 80.0x
            Sequencing Technology             :: Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_021432185.1-RS_2024_03_31
            Annotation Date                   :: 03/31/2024 06:21:25
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,070
            CDSs (total)                      :: 1,966
            Genes (coding)                    :: 1,939
            CDSs (with protein)               :: 1,939
            Genes (RNA)                       :: 104
            rRNAs                             :: 8, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 78
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 27
            CDSs (without protein)            :: 27
            Pseudo Genes (ambiguous residues) :: 0 of 27
            Pseudo Genes (frameshifted)       :: 10 of 27
            Pseudo Genes (incomplete)         :: 10 of 27
            Pseudo Genes (internal stop)      :: 12 of 27
            Pseudo Genes (multiple problems)  :: 4 of 27
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:32:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 92836
            Orig. end                         :: 118803
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP090412.1.
            Bacteria and source DNA available from Andrey Karlyshev, Kingston
            University London, United Kingdom.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25967
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="2"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25967
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25967
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15967](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15967
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    130..145
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 20.45"
                     /tool="antismash"
     misc_feature    complement(468..482)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.77"
                     /tool="antismash"
     misc_feature    733..748
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 20.61"
                     /tool="antismash"
     misc_feature    complement(750..764)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.85"
                     /tool="antismash"
     gene            1266..2069
                     /locus_tag="LZF92_RS09845"
                     /old_locus_tag="LZF92_09845"
     CDS             1266..2069
                     /NRPS_PKS="Domain: PKS_KR (11-172). E-value: 3.8e-08.
                     Score: 25.4. Matches aSDomain:
                     nrpspksdomains_LZF92_RS09845_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003706807.1"
                     /locus_tag="LZF92_RS09845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LZF92_09845"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_014573624.1"
                     /sec_met_domain="adh_short (E-value: 2.5e-32, bitscore:
                     105.5, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSENWLNLNEKVYIVTGGSSGIGEAIVKELLNDGAYVYDADLQPA
                     KEEHDHLTFVETDVTNKGQVDALVARVVEEHGHVDGVVNNAGINLPRLLVDAKESNSKY
                     ELTENDFDKMFNVNVKSVFLMSQAVARQLVKQKSGVIVNMASEAGLEGSQGQSIYSGTK
                     AAIVGLTRSWAKELGEFNVRVVGVAPGIMEATGLRTLAYEEALAYTRHKTVEDVRAGYK
                     SKSTTPLGRSGKLSEVADLVAYYLSDRSSYITGVTTNVAGGKSRG"
     CDS_motif       1299..1370
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_LZF92_RS09845_0001"
                     /evalue="8.90E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="LZF92_RS09845"
                     /protein_end="35"
                     /protein_start="11"
                     /score="18.4"
                     /tool="antismash"
                     /translation="VYIVTGGSSGIGEAIVKELLNDGA"
     aSDomain        1299..1781
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_LZF92_RS09845_PKS_KR.1"
                     /evalue="3.80E-08"
                     /label="LZF92_RS09845_PKS_KR.1"
                     /locus_tag="LZF92_RS09845"
                     /protein_end="172"
                     /protein_start="11"
                     /score="25.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VYIVTGGSSGIGEAIVKELLNDGAYVYDADLQPAKEEHDHLTFVE
                     TDVTNKGQVDALVARVVEEHGHVDGVVNNAGINLPRLLVDAKESNSKYELTENDFDKMF
                     NVNVKSVFLMSQAVARQLVKQKSGVIVNMASEAGLEGSQGQSIYSGTKAAIVGLTRS"
     gene            2085..3944
                     /locus_tag="LZF92_RS09850"
                     /old_locus_tag="LZF92_09850"
     CDS             2085..3944
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003699439.1"
                     /locus_tag="LZF92_RS09850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LZF92_09850"
                     /product="HTH domain-containing protein"
                     /protein_id="WP_014573623.1"
                     /transl_table=11
                     /translation="MNVLNYQLFKILTTNDSITVDRLVSELQVSKKTLQKYITSLNEEL
                     GEIAEIQEKNQKYYLKVEDYARLAKFQTHYLKTTLDFNNPLKRQAYILLMLIKSKGYML
                     LDDLSEYLMVSKGTINRDIKEIKLLLKDYDTTIRSVSNNGVMLESKEDCQIAFILRNFV
                     CDYYDLGEKLAIEEKQEITKLVRKYDKSKTVRNLIIRHLKILNFLHEHGRKISTTPDCY
                     YELTSSEVNDEILSILKKYLHSKEITEAEKSFLLIPLNINYSNRNTERINKRLMWIDEL
                     FAEIFSQVKENISLDIDYNRVFEQIKYHSIFMINRSATYMRNDDLFSREIVEKYPVAVD
                     LAIMTVNLLESKLHIKISDKELGYLALYYQMEIEDEKRGNPQYHKVAIVGEVSKSIQNL
                     IISRLNETFQGTTEADVFKSSESFKKSSERYLIVFSTLPLESKDVTTPIVRIQSIFKND
                     ELVSKVTLSQVMAGISSQQVKFRIQRFEERISYLKAVENLIDTEISTGELLPEFKLDWK
                     KREEKMSNVFQNGIAIPHMVDKSNHSRILLTVGILSKAVKYQGKEVRIIFLIGIPQNLN
                     SKLSKILSRVYDLIFMISGYDEIYNNLLEYDMDLPLTQITEGI"
     gene            3945..4442
                     /locus_tag="LZF92_RS09855"
                     /old_locus_tag="LZF92_09855"
     CDS             3945..4442
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004564420.1"
                     /locus_tag="LZF92_RS09855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LZF92_09855"
                     /product="transcriptional regulator GutM"
                     /protein_id="WP_003699440.1"
                     /transl_table=11
                     /translation="MIILIGLIVVGAFLLQGLFGIFQIKNFSRNYRELRLLGPYRILIG
                     KNPKRFFSGSLMLIAIDNDGNIKEARLMQGVTVFAKFRTLKKLEGKNIAVLAADYQELK
                     RMNKLTRQCLLNAYKTFVDFKTQKLSASAYDTSVNVFNMPLFTKIGLMANNLKANMSKK
                     FN"
     gene            4454..4996
                     /locus_tag="LZF92_RS09860"
                     /old_locus_tag="LZF92_09860"
     CDS             4454..4996
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004564419.1"
                     /locus_tag="LZF92_RS09860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LZF92_09860"
                     /product="PTS glucitol/sorbitol transporter subunit IIC"
                     /protein_id="WP_003699442.1"
                     /transl_table=11
                     /translation="MDIVVNLASGFMNLFETGGKTFIGWMKTIVPVVLLLLVLMNTIIA
                     FLGEEKMDKIARGASKNIFTRYLILPFLSAFMLGNPMSFTMARFLPEYYKPSYYAAQAQ
                     FCHTSNGVFPHINPGELFVWMGIAQGVQKLGLNSMDLAIRYLLVGLVMNFIGGWVTDFT
                     TAYVCRTTGIKLSKTVD"
     gene            5013..6038
                     /locus_tag="LZF92_RS09865"
                     /old_locus_tag="LZF92_09865"
     CDS             5013..6038
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014573622.1"
                     /locus_tag="LZF92_RS09865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LZF92_09865"
                     /product="PTS glucitol/sorbitol transporter subunit IIB"
                     /protein_id="WP_014573622.1"
                     /transl_table=11
                     /translation="MSKWNSIKIVKGSGGWGGPIVVTPTEEKHKVVYVTGGNRPDIVDT
                     IVELTGMEAIDGFKTAIPDEEIALAIVDCGGTLRCGIYPSKNILTVNVLPTGKSGPLAK
                     YITPELYVSAVTPKQISLVNAEDAEAIVKQQNEKATKEEVADDKEDGIDTSKTLTQQGH
                     GGGFIAKIGIGVGKVVATFNQAAKESVQTVLNTIIPFMAFVALLIGIIMGSGIGNWFAK
                     IMVPLAGNVWGLMILGFICSLPFLSPLLGPGAVIAQVIGTLIGVEIGKGHIPPQYALPA
                     LFAINTQNACDFIPVGLGLEEAKPETVEVGVTSVLYSRFLNGLPRVFVAWLASFGLYSG
                     K"
     gene            6075..6455
                     /locus_tag="LZF92_RS09870"
                     /old_locus_tag="LZF92_09870"
     CDS             6075..6455
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003702993.1"
                     /locus_tag="LZF92_RS09870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LZF92_09870"
                     /product="PTS glucitol/sorbitol transporter subunit IIA"
                     /protein_id="WP_041823183.1"
                     /transl_table=11
                     /translation="MFLQKKKTKLYETEVIEIGEEAKNFKEIKMVILFGEGAPDALRPS
                     CYIIKVNELSGEIKAGMTLQIDDEKYKITAVGNEVQTNLKNLGHIAINFTGDKTATLPG
                     SMYVEEKEYPKINEGTKIAIIK"
     gene            6522..7202
                     /locus_tag="LZF92_RS09875"
                     /old_locus_tag="LZF92_09875"
     CDS             6522..7202
                     /EC_number="4.1.2.-"
                     /GO_function="GO:0016832 - aldehyde-lyase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003699446.1"
                     /locus_tag="LZF92_RS09875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LZF92_09875"
                     /product="fructose-6-phosphate aldolase"
                     /protein_id="WP_161023451.1"
                     /transl_table=11
                     /translation="MEFLLDTVDLKKIKYYCDKLNVKGVTSNPTILKKDGVGDDLFAHL
                     KKIKEIIEDERELHVQVVAPSVSGMIDEAHKIVDEVGKDVYIKVPTTLDGLEVMKKLKA
                     EGIRVTATAIYTEFQGYQAINVGADYLAPYYNRMLNQNINSAEVIRNLSKRINLDNSNT
                     KILAASFHNVAQVNEALSNGAQAVTVGPDIVASAFKMPSISQAMADFRNDWESLYGDKN
                     INNL"
     gene            complement(7265..8260)
                     /locus_tag="LZF92_RS09880"
                     /old_locus_tag="LZF92_09880"
     CDS             complement(7265..8260)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003699447.1"
                     /locus_tag="LZF92_RS09880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LZF92_09880"
                     /product="D-2-hydroxyacid dehydrogenase"
                     /protein_id="WP_014573620.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 2.8e-53, bitscore:
                     173.1, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSIKMFGVRDEERPMAENWAKEHNVKIDMTSDILTSDTIDEVKG
                     FDGLTLMQVAEVTDDLYPKLKEFGIKQIAQRSAGYDMYNLDAAKENGIIITNVPSYSPE
                     SIAEYTVTTALNLVRKFPLIEKRVKEHNFSWEPEIRGRVIGDMTVAVIGTGRIGYHVAK
                     IFHGFGAKVVGYDLYPSDKLDGILEYRDSVEDAIRDADIISLHMPAFKENHHMFNYEMF
                     KKFKSDAVLVNMARGALIDTEDLLKALDDGLLAGAGLDVYEHEGPLVPIDLTGKDIEDE
                     TFKKVLESDKIIYSPHVAYYTDEAVRNLVEGGLNATLEVLETGDASTRVN"
     misc_feature    8454..8463
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 14.86"
                     /tool="antismash"
     gene            8467..9516
                     /locus_tag="LZF92_RS09885"
                     /old_locus_tag="LZF92_09885"
     CDS             8467..9516
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016853127.1"
                     /locus_tag="LZF92_RS09885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LZF92_09885"
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="WP_014573619.1"
                     /transl_table=11
                     /translation="METTKITPKVFIDRVLGGTAIGIIVGLIPNAVLAAILKMFGTNPF
                     AVHLGQAAIIFQLGTPLIIGTLIAQKFGFDGMKMTVVGGAAFVGSGVIKYFPALNKTGA
                     YVGAGTGDIINTMLTASIAVGLILLIGDKFGSVAIVLTPIVVGTGAGLIGFYMYPYVTA
                     ITSAIGNVINTFTELQPVLMCILIACSFAVLIISPISTVAIAMAIQVNGLAAGAAAMGV
                     AATTLVLVVNSWKVNKPGVTIAIALGAMKMMMPNLFRRPIILVPCFFTAIISAVPVALM
                     SISGSPASGGFGLVGLVGPLASIEKGLGVVAALLAWLVIPVIASLVGQFLFEKVFKLYD
                     RKDVFEFLG"
     gene            9742..9921
                     /locus_tag="LZF92_RS09890"
                     /old_locus_tag="LZF92_09890"
     CDS             9742..9921
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_a"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014570405.1"
                     /locus_tag="LZF92_RS09890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LZF92_09890"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_081539212.1"
                     /sec_met_domain="TIGR03731 (E-value: 3.4e-16, bitscore:
                     52.3, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_a (E-value: 1e-06, bitscore: 21.4,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVNDFKLDLVKVSKESTNSNYSVKITSYSLCTPGCKTGALMGCT
                     MKTASCGCHVHISK"
     CDS_motif       9742..9816
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSVNDFKLDLVKVSKESTNSNYSVK"
                     /locus_tag="LZF92_RS09890_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9817..9921
                     /prepeptide="core"
                     /locus_tag="LZF92_RS09890_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="12.40"
                     /molecular_weight="3329.0"
                     /monoisotopic_mass="3326.6"
                     /core_sequence="ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSVNDFKLDLVKVSKESTNSNYSVK"
                     /leader_location="[9741:9816](+)"
                     /alternative_weights="3347.0"
                     /alternative_weights="3365.0"
                     /alternative_weights="3383.0"
                     /alternative_weights="3401.1"
     gene            10001..12961
                     /locus_tag="LZF92_RS09895"
                     /old_locus_tag="LZF92_09895"
     CDS             10001..12961
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="LZF92_RS09895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LZF92_09895"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_081539211.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.4e-89, bitscore:
                     294.0, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.5e-11,
                     bitscore: 38.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3.5e-20, bitscore:
                     65.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNFNVSDVMIRNTIQTYEKSQNFNNYKEFIEIIKNDNIFLEQIL
                     LANPKLYGMLKKYNAGKLKKKKEKNFFESIYKYYKRSYYRATPFGLFSETSNGKFTVKG
                     DKKELGKTHKVVFIDIKWLTDVIFKLEKDYQSNLSFISNNGNYISGNRVMQLYSINDQD
                     LEEVSINNSKVYRIISEECSQTYKTYSEIIEKVITIYGNEYLNLTKEYINDLVENHYLI
                     SNLQENILINFSMSDFIMKVREIDVSKKYVEILTKIQELIEEYTHIEIGSGSDKLIEIY
                     HQMARLNKSDNYIQVDLYNDGNIYIDNSNKQRIEKFSNFITNTVKSVTRTYFDDYKDKF
                     IEKYGIDQDVQLIELFDPIKGIGAPYDYTHPQNEVFELEPPTSYYSHDEKEMYINKYIE
                     ALLNREEINLKCFSNYYRNLNSKESTSIQGIELFFHMVQINKKKTLALSNIIGSNNIGG
                     SSGRFSLLSDKLRDYHMKTLKQVKAANIEEGVTSCEIVFLPENIRHANIMRTSFVREKV
                     LPIFSSTDQSEVRLTNIYIGLDENENFYAYDVSTQEKMKFYVTSMYNKTLFSNELRFLC
                     EISINNNFGYVPWDLIYKDMNFIPRIMFEDIVVSPKTWRIFKFELSNIAIESIIKQRNI
                     PNEIYIVDGDNKLYINRKNSLDVELFMSEIKRNIEKNGHAIIQEYFNNKDMIYKDSEGK
                     ISEIVVPVINSKFDVKKVNKEKQQRISKHVREKLPFNDWLYLKVYMSTRRQEEFIRVYI
                     PLIQKKVEKLDGKLFFLRYMDPVPQIRIRISGNNLYKIYEVIKKDLEQGHRNGILSTFD
                     ISTYDREIERYGGVNAIDIAENIFCEDSKLVIKYLKFIKEKNMEDKLDDIAVAMIYFYL
                     KIFYKTNEDILCFLDKVCPNKVDKNVRSKIQYYKSVVFNQLTDIYEIDKYNFNRLKEEI
                     KKLKLIIDKKNADTIMDSIIHVHNNRLFGINRVREQNLYFIVKKMIMSEKYILKGK"
     aSDomain        10424..10678
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_LZF92_RS09895_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.90E-12"
                     /identifier="RREFam001.1"
                     /label="LZF92_RS09895"
                     /locus_tag="LZF92_RS09895"
                     /protein_end="226"
                     /protein_start="141"
                     /score="38.1"
                     /tool="antismash"
                     /translation="SNNGNYISGNRVMQLYSINDQDLEEVSINNSKVYRIISEECSQTY
                     KTYSEIIEKVITIYGNEYLNLTKEYINDLVENHYLISNLQ"
     gene            12964..14781
                     /locus_tag="LZF92_RS09900"
                     /old_locus_tag="LZF92_09900"
     CDS             12964..14781
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015425980.1"
                     /locus_tag="LZF92_RS09900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LZF92_09900"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_081539224.1"
                     /transl_table=11
                     /translation="MDEIKKLTSKNFFKTLLTLPDTIKLIFQLERKYATYLMCLNIVTA
                     LIPLLNLIVYQNLINSIFSRGMQLVYNIIYFLILQIFTVILSQLENYINGKFNMWLSYN
                     INLKLIKKTTSLKLTDYEQSDMYNLIEKITQDSTYKPFQLFNAVITMLAAFISLLTSLI
                     FVAAWNIWIGLLLLVTPMLSLIIFLKVGQLEFLIQWKRASAERKSWYIVYLLTHDFSFK
                     EIKLNNLSDYFVEEYKKLKKDFILQDLLIARKKAYFNSGLQILLDFINIFVICTIIVSV
                     QAGRILIGNLVSLMQAITKINGYSQTIIQNIYIIYNTSLFMEQLLNFLKIENQSDYREN
                     IGIGDENRIKRIDLIDVEYKYPNSSVNALEKINFSMHTGELIAIIGENGSGKSTLVKLI
                     SELYTPSKGHIYYNGIEDKHISTDFYQKNISILFQDFVKYELTLRENIGLGNIAEKWDD
                     NKIIHIMDKLRLNFLKENGEYNLNLQLGTWFQNGRQLSGGQWQKIALARAFFKNASVYI
                     LDEPSAALDPISEKEIFDYFVNLSKDNISIFISHDLNVARKASKIIVMNKGRVVGIGTH
                     EELLKDCSFYQELYWAEKYGRNKKKNFKK"
     gene            14747..15967
                     /locus_tag="LZF92_RS09905"
                     /old_locus_tag="LZF92_09905"
     CDS             14747..15967
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014570408.1"
                     /locus_tag="LZF92_RS09905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LZF92_09905"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_143455545.1"
                     /sec_met_domain="LANC_like (E-value: 1.7e-57, bitscore:
                     188.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEIKRKILKNKFGRVILEWDRRIEQNAYRYNFEEFTLSSGLPGV
                     ILLLLEMEDLDRTYKSKIDQYCDYLYGKLSKYGLLTGSLYSGAAGIALSLLPLKKDLRF
                     QNLIASLNDYISYYVDKEIGEFNIGNVTPPNYDVIEGLSGILMYLLLIDNIDIKLVTKI
                     IIFLLTLLDDNDSLIAMYIKTGNQMSEAENEIYPNGCLNTGMSHGLAGVGSVLAYAYKK
                     GFMKKEILHGLERIIQIYEKFELVDKNKFHWKDGIDYNELVNNRTILKDNDLFIRDAWC
                     YGSPGISVLYLYIGLIQDNSYLIKKAIEILYRATKEMRNVDSNMICHGKSGIVSICILF
                     RKLTKTRKFDTFINNYTDEIESIFDKDIRNLGFLEGTTGIILTLNECFSNKGKTQWMKS
                     LMLFDDF"
     gene            16004..16693
                     /locus_tag="LZF92_RS09910"
                     /old_locus_tag="LZF92_09910"
     CDS             16004..16693
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000276750.1"
                     /locus_tag="LZF92_RS09910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LZF92_09910"
                     /product="response regulator transcription factor"
                     /protein_id="WP_081539210.1"
                     /transl_table=11
                     /translation="MYRILVIDDDVEILKLMKTALEMKNYEVVTCQNVHVPLKLSDFEG
                     FNLILLDIMMSKISGTEICYQIRSKISTPIIFISAKDDEEDILYGLKIGGDDYITKPFS
                     LKQLLAKIDANIKREERSRQAVRDFAEVKRDMGKITFYLEERRVCVNSQDIPLTSREYD
                     ILELLSRRTSHIYSREDIYNNVYDEYAETLFGSISEYIYQIRTKFAPFKLNPVQTIRGV
                     GYKWYEE"
     gene            16683..18026
                     /locus_tag="LZF92_RS09915"
                     /old_locus_tag="LZF92_09915"
     CDS             16683..18026
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017864239.1"
                     /locus_tag="LZF92_RS09915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LZF92_09915"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_081539209.1"
                     /transl_table=11
                     /translation="MKNKIHSMKWRIWKTAFEIFIETFLGLGLLLAITFILQKAGYISN
                     PNKVYLVLDSNKTTLTDIRQTMKKYPYDFIVFDRRTGKIVASRYQKNDKDNYYLAKVKN
                     KSYINGTTSYTISSNKLYSLVIRQNSVPEFTNPVLRKFSYNQISYIFLIIYESLIIIIA
                     IYKLIHEISKNFTAIQKIALNMGNKVTKDYPKSKIKEFDTVLKQLYQKSNELSTLIETE
                     RIEKEDLSFQVAALSHDIKTPLTVLKGNIELLELTNPDKRQLEFMESMKNSIQTLENYF
                     NTMINYTKLLNLNSISEEINLNEFIKELFLELTDIAIVNKTNNRLKVKTNLKKFHANVP
                     ALKRALINIFLNACQYADKSNPQVSVTVTEDLKFLWFEIWNNGAPFSEEAQVNAQKLFF
                     TEDKGRSGKHYGIGLSFAQAVAVRHGGTMIITNLVNDGVSVKLGIQKF"
     gene            18090..18770
                     /locus_tag="LZF92_RS09920"
                     /old_locus_tag="LZF92_09920"
     CDS             18090..18770
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012897845.1"
                     /locus_tag="LZF92_RS09920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LZF92_09920"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_081539208.1"
                     /transl_table=11
                     /translation="MKIEVKNISKKYQDREVLKDVSFTIEKGTICGLFGMNGVGKSTLM
                     KIIYGIEIPDKGQVLFEGHGKTSNIGALIEQPPIYSNLSAFDNLKTKALLYDIPNNQIK
                     DVLKRVGLDSTDKKHAGKFSVGMKQRLGIGMAILTQPKFIILDEPINGLDPDGVIEFLD
                     LLKSLKKQGVTILISSHQLHEIGRIVDQVIILDKGHVVYDKIQSNYKDIEEIFFNVMKG
                     ESFI"
     gene            18767..19483
                     /locus_tag="LZF92_RS09925"
                     /old_locus_tag="LZF92_09925"
     CDS             18767..19483
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LZF92_RS09925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LZF92_09925"
                     /product="hypothetical protein"
                     /protein_id="WP_081539207.1"
                     /transl_table=11
                     /translation="MIKALFSEILKLKKVRINKLLWIIPLLTGLIAFLVGGVIIFSPFA
                     IYWWESVFLYLLIGLLFLMDFNMEKKAGNFQNVKYNLWSFQIYLAKIFLIFVRVAISSL
                     FFIILVIVLNKFFSGYTELLLSKSILSIFLLLLSVFWNIPWLYFLANFINGYLLIAVNT
                     LVCLLFGSIISQTQWWFAFPYSYHYKISQYLLGVQPSGIFKIINLQLFDVMSPVLLSLL
                     ISLLLIYFTRWGKSND"
     gene            19476..20129
                     /locus_tag="LZF92_RS09930"
                     /old_locus_tag="LZF92_09930"
     CDS             19476..20129
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LZF92_RS09930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LZF92_09930"
                     /product="hypothetical protein"
                     /protein_id="WP_081539206.1"
                     /transl_table=11
                     /translation="MIRSELLKLKSSPTIYLLVSFTIFEIASAYGYLYWHRNLLTYKNI
                     VLAFALAYPSLISVITNICFEQEREANNFQEVRKYSQVKLLTIKTLILDLLLWWISFFV
                     WWIISYSIAQVKLGIISGIAMWLLIVLLNHSHMFLYMVTNKYINLVFSLVEILFIIFAS
                     NKTLMSAYWCFVAWPINYLIHADNSKLYFSAMWILILTILDYFIFRSIELERID"
     misc_feature    complement(20577..20592)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.2"
                     /tool="antismash"
     misc_feature    20658..20674
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 20.28"
                     /tool="antismash"
     misc_feature    20839..20859
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 25.38"
                     /tool="antismash"
     gene            20906..21187
                     /locus_tag="LZF92_RS09935"
                     /old_locus_tag="LZF92_09935"
     CDS             20906..21187
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015521010.1"
                     /locus_tag="LZF92_RS09935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LZF92_09935"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_047036161.1"
                     /transl_table=11
                     /translation="MKPMYVSINSEKTGANLKSLFKNNGYSVRDIQSVMGFENPQSIYK
                     WLSGRSLPSLDNLVILSKVLHTTIEDILVVDGDVVFLFNLTWTIQLNR"
     gene            21209..21457
                     /locus_tag="LZF92_RS09940"
                     /old_locus_tag="LZF92_09940"
     CDS             21209..21457
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LZF92_RS09940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LZF92_09940"
                     /product="type II toxin-antitoxin system HicB family
                     antitoxin"
                     /protein_id="WP_081539204.1"
                     /transl_table=11
                     /translation="MQEVMSYRGYKGTIEYSLEDNILHGEVLGIRSLLSYEGNTLQELK
                     DDFEDTIDDYFECCKNHNMTPEKPYKQNIVINLEPDL"
     gene            21575..21763
                     /locus_tag="LZF92_RS09945"
                     /old_locus_tag="LZF92_09945"
     CDS             21575..21763
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LZF92_RS09945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LZF92_09945"
                     /product="hypothetical protein"
                     /protein_id="WP_081539203.1"
                     /transl_table=11
                     /translation="MKKSRVNKIKIESKKALVVRRLDWRAPSSRINYSILEMIDDLNDS
                     KLERASNLAELESLLNK"
     gene            22172..23806
                     /locus_tag="LZF92_RS09950"
                     /old_locus_tag="LZF92_09950"
     CDS             22172..23806
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003706793.1"
                     /locus_tag="LZF92_RS09950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LZF92_09950"
                     /product="peptide ABC transporter substrate-binding
                     protein"
                     /protein_id="WP_014573618.1"
                     /transl_table=11
                     /translation="MKRIKAIITGIFISLTAILLVACGKSTGENSKQVLNLSTTGPLDT
                     IDISKSTGYGQTGNVFESFYRLGKDGKVTPGLAKSGQVSQDGKTWTFTLRDAKWSNGDK
                     ITAQDFVYSWKRTIDPKTASPYAYLFYDVKNAQAINEGKMSADKLGIKAEGDNKVVITL
                     DRPISYFKVLMTYPLFGPQSEKVVQKYGKKYGTNSKYMVYSGPFKVKDWNGTSDKWSFV
                     KNNQYWDKKVVKLQKINYQVVKNTNTGYQLFQQGKLDLTPLSSEQVKNLHNKPEFKQYS
                     YSYVAYLDYNFNDSNEVNRKALNNKNIRLALSLAIDRKTLTKKVFGDGSNVPTGFVASD
                     LATNPKTGKDFAAEQKVDNTVDYNEKLAREYWKKGLQEIGEKNLNFTILASNEMANNDA
                     LTQYLQSQYTKVLPGIKVSVQNIPGNSALSKARKGNYDIYVSGWGGDFKDPITFMQIPV
                     TGTSYNYGKYSNKEYDALIEKAQNEDANDANKRWEDLVKAARLFNADQGVTPLYQQTTS
                     YMQNTKVKGIIQNTAGTQWNYKYAYIK"
     gene            24069..24848
                     /gene="sufC"
                     /locus_tag="LZF92_RS09955"
                     /old_locus_tag="LZF92_09955"
     CDS             24069..24848
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016226 - iron-sulfur cluster assembly
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="sufC"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014573617.1"
                     /locus_tag="LZF92_RS09955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LZF92_09955"
                     /product="Fe-S cluster assembly ATPase SufC"
                     /protein_id="WP_014573617.1"
                     /transl_table=11
                     /translation="MSVLEVKDLHVTVEGKKILKGVNLKMSTGEIHAIMGPNGTGKSTL
                     SSTIMGDPAYKITKGDILLNGKSIIDLPVDERARMGLFLAMQYPQEIPGVTNAEFVKSA
                     INARRPKDDPIPLMDFIKRLDETLETLDMSEEMADRYLNEGFSGGEKKRNEIMQMMMIR
                     PEFAILDEIDSGLDIDALKVVSRGVNQMRGDNFGSLIITHYQRLLNYIIPDYVHVMMDG
                     RLVKTGGPDLAIRLEKEGYAKLRDELGLDIKLVDENA"
     misc_feature    25715..25729
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: weak, score: 17.04"
                     /tool="antismash"
ORIGIN
        1 agtaaggtta gtatcccatt attagctaaa actgcaacaa aaaggaaaag taaggtagtc
       61 attaacaact caaacatctt tattaaagaa ttaagagggt tagtattagc aaaacgtcct
      121 cctaaagtat tgccaatagc gaccattact ccgtaaataa ctaaaataat aacaatggcg
      181 tttgctgaaa agcctactcc ttctaataat ggagaaagat aagtatatgc tgcaaaagtt
      241 cctccatagc caaaagcagt aatcaggaat gatagaacta aaggtttgtt agtaaagata
      301 cgaataaaac catgcaaatc tacttttcca ggaattggta aagatttagg aattagaaaa
      361 taatcagcaa ttaaaccaat aagtcccacg gtagcgatga agataaaaga catattccaa
      421 gaagtttgtt gaccaataaa agtacccaaa ggaacacctg taacagttgc aacagttagt
      481 ccggtaaaca taattgcaat agcactagca cgacgagatg gttcaactac atcagcagct
      541 ataactgttg aaattgacat gaatattcca tgagctaaag cggctaaaat tctacccaat
      601 agtaaaatag caaaaaacgg agcaaaagct gcaagtaaat tacctattat aaataaagtc
      661 atgattccta gcattaagga atggcggctc catttaccag ttaaaatcgt taacaaaggt
      721 gcgccaatag ttacgcctaa agcatacaat gaaacagtta gtccagcttg agataaacta
      781 atattgaaac ttttaacgat cattggaagt aatccaacgc taataaattc agtagaacct
      841 attgcaaaag cattaatagc cagtgcaaat aatgttaaac gaggtgaaat tttattcatc
      901 ttaaaaattc tttcctttca tatattaagt tgatgaagat aatatatact atttagttac
      961 tttttgtaag tacgaacttt aaagtaacat aggtactttt tagtaacttt tgtgtaagtt
     1021 agagaaaata ggaaagaaaa aataataata tcgtattaaa ggatataaga tgataaaaaa
     1081 tattatttaa aataattacc tactatatat tgatttaaat ttatgttaac tgtataattt
     1141 tatttaaata tttaattcat gcaatatttt tctcagattt tagaaattct tggtattaat
     1201 tgttgtaacc gttaacacta aaataagaat tgtaataaag atataaagtt attggaggaa
     1261 ttcttatgag tgagaactgg ctgaacttaa atgaaaaggt gtacattgta acaggtggtt
     1321 cttctggtat cggggaagca attgtaaaag aattattaaa tgacggcgca tatgtatatg
     1381 atgcagattt acaaccagct aaggaagaac atgatcattt aacatttgta gagacagatg
     1441 taacaaataa aggacaagtt gatgcattag ttgctagagt tgttgaagaa catggacatg
     1501 ttgatggtgt tgtaaataat gcaggtatta acttaccaag attgttagta gatgctaagg
     1561 aaagcaatag caaatatgaa ttaactgaaa atgattttga caagatgttt aatgtcaatg
     1621 taaagagtgt atttttgatg tcacaagctg ttgctcgtca attagtaaaa caaaaatcag
     1681 gtgtaattgt taatatggct tctgaagctg gtctggaagg ttcacaagga caaagcattt
     1741 attcaggaac taaagcagca atcgtaggtt taacacgttc atgggcaaaa gaattaggtg
     1801 aattcaatgt tcgtgtagta ggtgtagctc ctggaattat ggaagcaaca ggtttaagaa
     1861 cactagctta tgaagaagct ttggcatata caagacataa aacggttgaa gatgtccgtg
     1921 caggatacaa gagtaagagt actacaccat taggaagaag tggtaaatta tcagaagttg
     1981 ctgatttagt tgcctactac ttatcagaca gatcaagtta tataacaggt gttacaacaa
     2041 acgttgccgg aggaaaatct cgcggataga aagtgggata ggttatgaat gtattaaact
     2101 atcaattgtt taagattctt acgacaaatg attcgattac agtagatagg ttagttagtg
     2161 agttacaggt atctaagaaa actttacaaa agtatataac gagtttgaat gaagaattag
     2221 gcgaaatagc tgagattcaa gaaaaaaatc aaaaatatta tttgaaagtc gaagattatg
     2281 ctagattagc taaatttcag acgcattatt taaagacaac tttggatttc aataatcctt
     2341 taaaacgtca agcatatata ttattgatgc tgattaaatc taaaggatat atgttacttg
     2401 atgatttatc tgaatatttg atggtaagta aaggtacaat caatcgtgat attaaagaaa
     2461 taaaacttct attaaaagat tacgatacta ctattcgatc ggtaagtaac aacggagtaa
     2521 tgttagaaag taaggaagac tgtcagattg ctttcattct acgtaacttt gtttgtgact
     2581 actatgattt gggtgagaaa ctagcaattg aagaaaagca ggaaataacc aaattagtta
     2641 gaaagtacga taaaagtaaa acagtacgta atttaataat aagacatttg aaaatactta
     2701 acttcttaca tgagcatggt agaaaaattt caacgacgcc agattgttat tatgaattaa
     2761 ctagttctga agtaaatgac gaaattctat ctatattaaa gaagtattta cattcaaagg
     2821 aaataacaga agcagaaaaa agcttcctat taataccact gaatatcaat tatagtaata
     2881 gaaatactga acgaataaat aaacgcttga tgtggataga tgaattattt gcagaaattt
     2941 ttagtcaagt taaggaaaat atcagtctag atattgatta caatcgagtc tttgaacaga
     3001 taaagtatca ttcaattttc atgataaata gaagtgccac atatatgaga aatgatgatc
     3061 tattcagtcg agaaattgtt gaaaaatatc cagtggcagt agatttagct attatgacag
     3121 ttaatttatt agaaagtaaa ctgcatatta agatttcaga taaagaattg ggttatttag
     3181 cactttatta tcaaatggaa atagaagatg aaaaaagagg gaatcctcaa tatcataaag
     3241 ttgcgattgt tggtgaagta agtaaaagta ttcaaaattt gattattagt aggttaaatg
     3301 aaacttttca aggaacaact gaagcagatg ttttcaagag tagtgaaagt ttcaagaaat
     3361 cgtccgaacg ttacttgatt gtattttcaa ctttaccact tgaaagtaaa gatgttacaa
     3421 ctccaattgt tagaattcag agtatcttta agaatgacga attagttagc aaagtaactc
     3481 tatcgcaagt tatggcggga attagtagcc aacaagtaaa atttagaatt caaagatttg
     3541 aagaaagaat ttcctatttg aaagctgttg agaatttaat tgatacagaa atttcaacag
     3601 gtgaattatt accagaattt aagctagatt ggaagaaaag agaagaaaaa atgagtaatg
     3661 tcttccaaaa tgggattgca attccgcata tggttgataa atctaatcat tctagaatat
     3721 tgttgacagt tggcatctta tcaaaagctg taaaatatca gggaaaagaa gtaagaatca
     3781 ttttcttaat aggtataccg caaaatctaa actctaaatt gagtaagatt ctgtctcgcg
     3841 tatacgactt aatctttatg atttcaggat atgatgaaat ttataataat ttgttggaat
     3901 atgacatgga tttaccatta acacagataa cggagggaat atagatgatt attttaatag
     3961 gattgattgt tgtaggggcg tttctcttac aaggattgtt tggaatcttt caaattaaaa
     4021 atttttccag aaattatcgt gaactaagat tactaggacc ttatcgcatt ctgattggta
     4081 aaaatcctaa acgcttcttt tcaggttcat tgatgttgat agcgatagat aatgatggaa
     4141 atataaaaga agctcgttta atgcaagggg ttacagtgtt cgctaaattt agaacattga
     4201 agaaactcga aggtaaaaac atcgcggttt tagctgcaga ttatcaagag ttaaagagaa
     4261 tgaataaatt gactagacaa tgtttattga atgcttacaa aacttttgtt gattttaaga
     4321 cacaaaaatt gtcagcaagt gcttacgata caagtgtaaa tgtgttcaat atgccattat
     4381 ttacaaagat tggtttaatg gcaaacaatt tgaaggcaaa tatgtcaaag aaatttaatt
     4441 aggagatgat ctcatggata tagttgtaaa tcttgcatca ggttttatga acctctttga
     4501 aacaggtgga aaaacattca ttggttggat gaagacaatc gtaccagttg tattgctatt
     4561 attggtttta atgaatacaa ttattgcatt cttaggtgaa gaaaagatgg ataagattgc
     4621 tagaggggca tctaagaaca tctttacacg ttatctaatt ttgccattct tatcagcatt
     4681 tatgttaggt aatccaatgt cctttacaat ggctcgtttc ttacctgaat actacaagcc
     4741 aagttactac gctgcacaag ctcaattctg tcatacaagt aatggggtat tccctcacat
     4801 caatccaggt gaattgtttg tatggatggg tatcgcacaa ggtgtacaaa aattaggttt
     4861 gaatagtatg gacttagcta ttagatactt attagtaggt ttagttatga acttcatcgg
     4921 tggttgggta actgacttta caactgctta tgtatgtcgc acaactggaa tcaagttatc
     4981 taagacagtg gattaattgg aggtaatgaa ctatgagtaa atggaacagt attaaaatcg
     5041 taaaaggctc aggtggttgg ggtggtccaa tcgttgtaac accaacagaa gaaaaacata
     5101 aagtagttta tgtaacaggt ggtaatagac cagatattgt tgatacaatt gttgaattaa
     5161 caggtatgga agctattgat ggttttaaga cagcaattcc tgatgaagaa atcgcattag
     5221 caatcgttga ctgtggtggt accttacgtt gtggtattta cccaagtaaa aatattttaa
     5281 cagtaaatgt tcttccaaca ggtaaaagtg gtcctttagc taaatacatt actccagaat
     5341 tatatgtatc tgctgtaact ccaaagcaaa tttcattagt aaatgctgaa gatgcagaag
     5401 caattgttaa acaacaaaat gaaaaggcta ccaaagaaga agttgcagat gataaagaag
     5461 acggaataga tacttctaaa acattgacac aacaaggtca tggtggcgga tttatcgcta
     5521 agattggtat tggtgtaggt aaagttgttg ctacatttaa ccaagctgct aaggaatcag
     5581 tacaaacagt tttgaataca attattccat ttatggcatt tgttgctttg ctaatcggta
     5641 ttatcatggg ttccggtatt ggtaactggt tcgctaaaat catggtacct cttgcaggta
     5701 acgtttgggg cttgatgatt ttaggtttca tttgttcatt gccattctta tcaccattgc
     5761 ttggaccagg tgctgtaatt gcccaagtta tcggtactct aattggtgtt gaaattggta
     5821 aaggtcatat tcctccacaa tatgcattac cagcattgtt cgctatcaat actcaaaatg
     5881 cctgtgactt cattcctgtt ggtttaggtc ttgaagaagc taagccagaa acagttgaag
     5941 ttggggttac atctgtattg tactcacgtt tcttaaacgg tttacctcga gtatttgtag
     6001 catggttagc tagtttcgga ttatattcag gaaaataaaa gtaaaaatga attgatgatg
     6061 aggtgtgatt tgttatgttc ttacaaaaga aaaagactaa gctttatgaa acagaagtta
     6121 tagaaattgg tgaagaagct aagaatttca aggaaattaa gatggttatc ttatttggtg
     6181 aaggggctcc agatgcactt agaccatcct gctacatcat taaagtaaac gaattatctg
     6241 gtgaaataaa ggcaggtatg actttacaaa ttgacgatga aaaatataaa ataacagcag
     6301 taggtaacga agttcaaact aacttgaaga acttaggtca tatagccatt aacttcacag
     6361 gggataaaac tgctacatta ccaggatcaa tgtacgtaga agaaaaggaa taccctaaaa
     6421 ttaatgaagg tacaaagatt gctattataa aataaattag ggaagcatag ggagcgttga
     6481 ggtttctcta tgcttttcta gcatgaaagg acaaaataga tatggaattt ttattagata
     6541 cagttgattt gaaaaagatt aaatattact gtgataaatt aaatgttaaa ggagtaactt
     6601 ctaatccaac gattctaaaa aaagatggag taggcgatga tttattcgca catcttaaaa
     6661 aaataaagga aatcattgaa gatgaaagag aactccacgt acaagttgtg gcaccttcag
     6721 tatctggaat gatagatgaa gctcataaaa ttgtagatga agtaggtaag gatgtataca
     6781 tcaaagttcc aactacttta gatgggttag aagtcatgaa aaaactaaag gctgaaggaa
     6841 ttagggtaac agcaactgca atttatacgg aatttcaagg ttatcaagca atcaacgttg
     6901 gtgctgacta cttggctcct tactataata gaatgttaaa tcaaaatatt aattcagctg
     6961 aagttattag aaatctatct aaaagaatta atttagataa tagcaatact aaaattttag
     7021 ctgcaagttt ccataatgta gcacaagtaa atgaagcatt aagtaatggt gctcaagctg
     7081 taacagttgg tcctgatatt gtagcatctg cttttaagat gccgtctatt tctcaagcta
     7141 tggcagattt tagaaatgac tgggaaagtc tatacggtga taaaaatata aataacttat
     7201 agtaagtata taacaaaaaa cctctgagat ggattctcag aggcttttat taggattaaa
     7261 ctaattagtt tacacgtgtt gaagcatcgc cagtttccaa tacttccaaa gtagcattta
     7321 agccaccttc aactaagttt ctaacagctt catcagtgta gtatgctacg tgtggtgagt
     7381 agataatctt atcagattca agtactttct tgaatgtttc gtcttcaata tcttttccag
     7441 ttaggtcaat aggaactaat ggaccttcgt gttcgtaaac gtcaagacca gctccagcca
     7501 aaaggccatc atctaaagct ttcaataaat cttctgtatc aattaaagca ccacgagcca
     7561 tgttaactaa tacagcgtca gatttgaatt tcttgaacat ttcgtagtta aacatgtggt
     7621 ggttttcctt gaaagcaggc atatgtaaag aaataatgtc tgcatcgcgg attgcatctt
     7681 ctacagaatc acgatattcc aagataccgt ctaatttgtc actaggatat agatcatatc
     7741 cgacaacttt agcaccaaaa ccatggaaga ttttagctac atggtaacca atacggccag
     7801 ttccgataac agcaactgtc atgtcaccga taacacgacc tctgatttca ggttcccatg
     7861 agaaattatg ttccttaaca cgtttttcaa ttagtgggaa tttacgtact aagttcaatg
     7921 ctgtagttac agtatattca gcaattgatt ctggggagta gctaggcaca ttagtaataa
     7981 taatgccatt ttctttagca gcatctaaat tgtacatatc ataaccagca ctacgttgtg
     8041 cgatttgttt gataccaaat tctttcaatt taggatataa gtcatctgta acttctgcta
     8101 cttgcattaa agttagaccg tcaaaaccct taacttcatc gatagtatca gatgtaagga
     8161 tgtcactagt catatcaatt ttaacgttgt gttcctttgc ccagttttca gccattggac
     8221 gttcttcatc acgaacacca aacattttga ttgaaaccat taaaaattcc tcctcatata
     8281 aatgataacc tttacaatat atattatatc atcattataa cagaatactt aaatataagt
     8341 gttaaattta attaattttt tacgtttttt tctaataaaa gaaagaaact aaagaaaaat
     8401 atatttacat tgctcacaat ctcacttata ataatgtgta tattttatat aaagaaggtg
     8461 acgaatttgg aaacaacaaa gattacaccc aaagttttca ttgatcgtgt tttaggcggt
     8521 actgccatcg ggattatagt tggtttaatt cctaatgctg ttcttgccgc tatcctcaag
     8581 atgttcggca ctaatccttt tgccgtacat ttaggacaag cagcaattat tttccaatta
     8641 ggaacacctt taattattgg tacattgatt gctcaaaagt ttggctttga tggcatgaag
     8701 atgaccgtag ttggtggagc cgcatttgta ggttctggcg taattaaata cttcccagcg
     8761 ttgaataaaa caggtgccta tgtaggtgct ggaacagggg atattattaa taccatgtta
     8821 acagcatcga ttgcagttgg attaattctg ttgataggcg ataaatttgg atcagtagca
     8881 attgttttaa caccaattgt agtaggaaca ggtgctggct taattggatt ctatatgtat
     8941 ccatatgtta cagcgataac ttccgcaatt ggtaatgtga ttaacacatt tacagaatta
     9001 caaccagttt taatgtgtat tttaattgcc tgctcttttg cagtgttaat tatctctcca
     9061 atttcaacag tagcgattgc aatggctatc caagttaacg gcttggctgc tggtgctgct
     9121 gcaatgggag ttgctgcaac aacacttgta cttgtagtaa actcatggaa agttaacaag
     9181 ccaggggtaa caattgcgat tgccttaggt gcgatgaaga tgatgatgcc taacttattt
     9241 agacgtccaa ttatcttagt accatgtttc tttacagcaa taatttctgc agttcctgta
     9301 gctttgatgt caatttcagg ttctcctgct tccggtggtt ttggtttagt aggtttagta
     9361 ggaccattag catcaattga aaaaggctta ggcgttgtcg cagcattgct agcatggtta
     9421 gttattccag ttattgcgtc acttgtcggt caattcttat ttgaaaaagt atttaagtta
     9481 tatgaccgca aagatgtttt tgaattttta ggttagaaaa tattagaatt gaatctaatt
     9541 aaaaatagtt taagttaaga aaatgctgaa ggttacattg ctgaaatgtt aatctttggc
     9601 attttttatt ttaaagattt ttccatggtt ttaaaattat cagtttaaat aatatgtatt
     9661 ctgaacaaaa tctgaaaata ataacatatt atagtgacgt tctagaacaa acaattaaag
     9721 ggttattagg aggttttcta aatgagtgtt aatgatttta aattggattt agtaaaagta
     9781 tcaaaggaaa gtacaaattc aaattattca gttaaaatta caagctactc actttgtacc
     9841 ccaggttgca aaacaggtgc actaatggga tgtacaatga aaactgcatc atgtggttgt
     9901 catgtacata taagtaaata gtaagaaagt aagggatagc gtagatcaat ttgatgattt
     9961 gctatcccat ttttttaata ggtgaaaggg gcttgaaaaa atgaataatt tcaatgttag
    10021 tgatgtaatg atacgtaata caattcaaac atatgaaaaa agtcaaaatt tcaataatta
    10081 taaggaattt attgaaatta ttaaaaatga taatattttt cttgaacaaa tattattggc
    10141 taatcctaag ctgtatggaa tgcttaaaaa gtataatgca ggaaaactaa agaaaaagaa
    10201 agaaaaaaat ttttttgaat caatatataa atattataaa aggagctatt atcgagcaac
    10261 tccttttgga ctatttagtg aaacttctaa tggtaaattt accgttaagg gtgataagaa
    10321 agaattaggg aaaacacaca aagtagtttt tatagatatt aaatggttaa cagatgtaat
    10381 ttttaaatta gaaaaggact atcaatcaaa cttatctttc atatctaata atggaaatta
    10441 cattagtgga aatcgtgtta tgcaattata ttcaataaat gatcaagatt tagaggaagt
    10501 tagtattaat aactctaaag tttatcgaat tatatcagaa gagtgtagcc aaacttataa
    10561 gacatatagt gaaatcatag aaaaggttat aacaatatat ggtaatgaat acttaaattt
    10621 aacaaaagaa tatattaatg atttagtaga gaatcattat ctaatatcaa atttacaaga
    10681 aaatatacta attaattttt ctatgtcaga cttcataatg aaagttaggg aaatagatgt
    10741 tagtaaaaaa tatgtagaaa tattaacaaa gatacaagag ttaattgaag aatatacaca
    10801 tattgaaata ggttcgggtt ctgataaatt aattgaaata tatcaccaaa tggctagact
    10861 taataaaagt gataattata ttcaagtaga tttatataat gatgggaata tatatattga
    10921 taatagtaat aaacaaagaa tagagaaatt ttcaaatttt ataactaata ctgttaaatc
    10981 agtaactagg acttattttg atgactataa agataaattc attgaaaaat atggtattga
    11041 tcaagatgtg cagttaatag aactatttga tccaataaaa ggaattggcg caccgtatga
    11101 ttatacgcat cctcagaatg aagtttttga attagagcct ccaacgtcat attattccca
    11161 tgatgaaaaa gaaatgtata ttaataaata tatagaagct ttattaaata gagaggaaat
    11221 taatttgaaa tgcttttcta attattatag aaatctgaat tccaaagaaa gtacctcaat
    11281 acaaggaata gaattatttt ttcatatggt ccaaattaat aagaagaaaa ctttagcatt
    11341 aagcaatatt ataggcagta ataatatagg gggatcctct ggaaggttct cattattatc
    11401 agataaatta agggattatc acatgaagac acttaaacaa gtgaaagctg caaatattga
    11461 agaaggggtg acgtcttgtg aaatagtttt tcttcctgaa aatatacgac acgctaatat
    11521 aatgcgaaca tcttttgtaa gagaaaaagt tcttcctatt ttctcaagta ctgatcaatc
    11581 tgaagtaagg ctaactaata tttatattgg attagatgaa aatgaaaatt tttatgcgta
    11641 tgatgtgtct actcaagaaa aaatgaagtt ttatgtaaca agcatgtata acaagacatt
    11701 atttagtaat gaactaagat ttttatgtga aatttcaata aataataatt ttggatatgt
    11761 accatgggat ttaatctata aagatatgaa ttttattcca cgaattatgt ttgaggatat
    11821 agtagtcagt cctaagacat ggagaatatt taaatttgaa ttaagtaata tagcaataga
    11881 gtcgattata aagcagagaa atataccgaa tgaaatttat attgttgacg gtgataacaa
    11941 actatatatt aatcgtaaaa attcacttga tgttgaactg tttatgtcag aaataaaaag
    12001 aaatatagaa aagaatggtc atgccattat acaagaatat tttaataata aagacatgat
    12061 atataaagat agtgaaggaa aaatatcaga gatagtggtt ccagttatta atagtaaatt
    12121 cgatgttaaa aaagtaaaca aggaaaaaca acagagaatc tccaaacatg ttcgagagaa
    12181 attgccattc aatgattggt tatatctaaa agtgtatatg tcgactagga gacaagaaga
    12241 gtttatacga gtttacatac ctctgattca aaaaaaggta gaaaaattag acggaaaact
    12301 atttttctta cgttatatgg atccagtacc acaaataagg ataaggataa gtggtaataa
    12361 tttatataaa atatatgaag ttattaaaaa agatttggag caaggtcata gaaatggtat
    12421 tttatcgact tttgatattt ctacatatga tcgcgaaatt gagagatatg gaggagttaa
    12481 tgcaatagat atagctgaaa atattttctg tgaagattct aaacttgtaa taaagtattt
    12541 gaaatttata aaagaaaaga acatggaaga taaacttgat gatattgcag ttgcaatgat
    12601 ttatttttat ttaaaaatat tttataaaac aaatgaagac attttatgtt ttctagataa
    12661 agtctgtccc aataaggtag ataaaaatgt aaggtctaaa atacaatact ataaaagtgt
    12721 agtatttaat cagttaactg acatatatga gattgacaaa tacaacttta atagacttaa
    12781 ggaagagatt aaaaaactaa aattaataat tgataaaaaa aatgctgaca ctattatgga
    12841 tagtattata catgtacata ataataggtt atttggaatt aatagggtta gggaacaaaa
    12901 tctgtatttt attgtaaaaa aaatgattat gtctgaaaaa tatattttga aagggaaata
    12961 atgatggatg aaataaaaaa actaacatca aaaaattttt ttaagacatt attaacactt
    13021 ccagatacga ttaagttaat ttttcaatta gaaagaaaat atgcaacata cttaatgtgc
    13081 ttaaatatag taacggcatt aattccgcta ttaaatttaa tagtttatca aaatctgatc
    13141 aatagtatat ttagtcgagg aatgcagctt gtatataata ttatttattt tttaatacta
    13201 caaatattta cggtaatatt atctcaatta gaaaattata taaacggaaa atttaatatg
    13261 tggctttctt acaatattaa tttaaaattg ataaaaaaaa caacctcctt aaagttgaca
    13321 gattatgaac aatcagatat gtataatctt attgagaaaa taacacagga tagtacgtat
    13381 aaaccatttc aactttttaa tgctgttatt actatgctgg ctgcttttat atctttactg
    13441 actagtttga tttttgttgc ggcgtggaac atatggatag gattgctgtt attagtaact
    13501 cctatgttat ctttaattat atttttaaaa gtaggtcaac ttgaattttt aatacaatgg
    13561 aaaagagcga gtgcagaaag aaagtcgtgg tatatagttt atttattgac acatgacttt
    13621 tcttttaagg aaattaaatt aaataattta agtgattatt ttgtggaaga gtataagaaa
    13681 ttaaaaaaag attttatatt acaagatttg cttattgcta gaaagaaagc atattttaat
    13741 tcgggacttc aaattttatt agactttatc aatatttttg ttatatgcac tattatagta
    13801 tctgtacaag ctggaagaat attaatagga aatttagtta gtcttatgca agcaattaca
    13861 aagataaatg gctattcaca aacaatcata caaaatattt atattattta taatactagt
    13921 ttgtttatgg agcaattact taattttttg aaaatagaaa atcaaagtga ttatcgtgaa
    13981 aacataggga taggtgatga gaacagaata aaaaggatag atctaataga tgttgaatat
    14041 aagtatccta actcttctgt caatgcttta gaaaaaataa acttttctat gcatacaggg
    14101 gaactaattg cgataatagg ggaaaatgga tctggtaaaa gtactctagt aaagttaatc
    14161 tcagagttat acacaccatc taaaggtcat atatattata acggtattga agataagcat
    14221 atatcgacag atttttatca aaagaatata tcgatattat tccaagattt tgttaaatat
    14281 gagctaactt taagggaaaa tattggtctt ggtaatattg cagagaagtg ggatgataat
    14341 aagattatac atattatgga taaattaagg ttaaattttt taaaagagaa tggagaatat
    14401 aatttaaatt tacaattagg aacttggttc caaaatggga ggcaattatc aggtggtcag
    14461 tggcaaaaaa tagctttggc tagagctttt tttaaaaatg cttctgtata tatattagat
    14521 gaaccaagtg cagcgctaga tccaatttca gaaaaagaaa tatttgatta ttttgtaaat
    14581 ctatccaaag ataatatatc tatttttatc tcacatgatt taaatgtagc tcgtaaggca
    14641 tcaaaaataa ttgttatgaa taaaggaaga gtagtaggta ttggaactca tgaagaactt
    14701 ttaaaagatt gtagtttcta tcaagaacta tattgggcag aaaaatatgg aagaaataaa
    14761 aagaaaaatt ttaaaaaata aatttggcag agtgatatta gaatgggaca ggagaattga
    14821 acagaatgct tatcgataca atttcgaaga attcacgctt tcttcgggat taccaggggt
    14881 tattttactg ttattagaga tggaagattt agataggaca tataagtcca aaattgatca
    14941 gtattgtgac tatttatatg gaaagttatc aaaatatgga cttttaacag gttctctata
    15001 ttcaggtgca gctgggattg cattaagttt attaccactc aaaaaagatt tgagatttca
    15061 aaatttaatt gcaagtctaa atgattacat tagttattat gtagacaaag aaattggaga
    15121 gtttaatatt ggaaatgtta ctccacctaa ttatgatgtg attgaaggat tatcaggaat
    15181 tctcatgtat ctgcttttaa tagataatat agatatcaaa ttagtgacaa aaattattat
    15241 ttttttatta accttattag atgataatga ttcattgata gcgatgtata ttaaaacagg
    15301 taaccaaatg tcagaggcag aaaacgaaat ttatcctaat ggttgtctaa atacaggtat
    15361 gtcacatgga cttgctggtg taggaagtgt attggcttat gcgtataaaa agggctttat
    15421 gaaaaaggaa atattacacg gattagaaag gattattcag atttatgaaa aatttgaatt
    15481 agttgataag aataaatttc attggaaaga tggaatagat tataatgaat tggttaataa
    15541 tagaacaatt ttaaaagata atgatttatt tataagagac gcatggtgtt acggtagtcc
    15601 aggaataagt gttttatatt tatatattgg actaattcaa gataattcat accttataaa
    15661 aaaagcaata gaaatactat atagagctac taaggaaatg cggaatgtag attccaacat
    15721 gatttgtcat ggcaagtcag ggatagtttc gatatgcatt ttatttagga aacttacaaa
    15781 aacgagaaaa tttgatacat ttataaataa ctatactgat gaaatagaaa gtatttttga
    15841 caaagatatt cgaaatttag gctttcttga gggaacaacg ggtattattt taactttaaa
    15901 tgagtgtttt tcaaataaag ggaaaacgca atggatgaaa tcattaatgt tatttgatga
    15961 tttttaactg tagttataaa aattattata aggaagagga cgtatgtata gaatcttagt
    16021 tatagatgat gatgtagaaa ttttaaaact tatgaaaaca gcattagaaa tgaaaaatta
    16081 tgaggttgta acttgccaaa atgttcatgt tccgttaaaa ttatcagatt ttgagggttt
    16141 taatttaatt ttattagata ttatgatgtc aaagatatca ggaactgaaa tttgttatca
    16201 gattcgttct aagatttcaa cgccaattat ttttataagt gctaaagatg atgaagaaga
    16261 tattttatat ggtttaaaaa ttggtggtga tgattatata accaaacctt ttagtttgaa
    16321 acagttatta gctaaaattg atgcaaatat taaacgagaa gaacgtagtc gtcaagcagt
    16381 tcgggatttc gcagaagtta agcgtgatat ggggaaaata actttttatt tggaagaacg
    16441 aagggtatgc gttaatagtc aagatattcc tttgactagt cgtgaatatg atattttaga
    16501 attgctctca cgaaggactt ctcatattta tagtcgtgaa gacatttata ataatgtata
    16561 tgacgaatat gcagaaactt tatttggatc tatttccgaa tatatatatc aaatccgaac
    16621 aaagtttgca ccatttaagt taaatcctgt tcaaacaatt cgtggtgtgg ggtataagtg
    16681 gtatgaagaa taaaatacat tctatgaagt ggcgaatatg gaaaacagct tttgagattt
    16741 ttattgaaac ttttttaggt ttaggtttgt tattagcaat aacttttatc ttgcagaagg
    16801 caggatatat atcaaatccg aataaagttt atttagtatt agattctaat aaaactactt
    16861 tgacggatat taggcaaacg atgaaaaaat atccttatga ctttattgta ttcgatagga
    16921 gaacaggaaa aattgtagca agtagatatc aaaaaaatga taaagataat tactacttag
    16981 ctaaagtaaa gaataaaagt tatataaatg ggactacaag ttatactata tcttctaata
    17041 agttatatag cttagtgatt agacaaaata gtgttccgga atttactaat ccagtcttga
    17101 gaaagttttc gtataatcaa atatcatata tatttttgat tatatacgaa tcattaataa
    17161 tcattattgc aatttataaa ctaattcatg agatttcaaa aaattttaca gctattcaaa
    17221 agattgcttt aaatatgggg aataaggtta ctaaagatta tcctaagtcg aaaattaaag
    17281 aatttgatac tgtattaaag caactctatc aaaaaagtaa tgagttatca actttaattg
    17341 agactgaacg gatagaaaaa gaagatttat catttcaggt agcagcatta tctcatgata
    17401 taaaaacacc acttactgta ttaaaaggaa atatagagtt gttggaactg actaatcctg
    17461 ataagagaca attagaattt atggaatcta tgaaaaacag tattcaaact ttagaaaatt
    17521 attttaatac aatgattaat tatactaagt tactaaattt aaattcaata agcgaagaaa
    17581 taaatttaaa tgaatttatt aaagaacttt ttcttgaact aacagatatt gccatagtca
    17641 acaaaacgaa taatcgatta aaggtaaaaa ctaatttaaa gaaatttcat gctaatgttc
    17701 cagctctaaa acgagcacta atcaacattt ttcttaatgc gtgtcagtat gcggataaaa
    17761 gtaatcccca agtatcggtt actgtaactg aagatttaaa atttttatgg tttgaaatat
    17821 ggaataatgg ggcaccattt tcagaagaag cacaagttaa tgcgcaaaag ttatttttta
    17881 ctgaagataa aggccgtagt ggaaagcatt atggaattgg actatctttt gcacaagcgg
    17941 ttgcagtcag acatggtggt accatgataa ttacaaatct agtaaatgat ggggtgagtg
    18001 taaagttagg aatccagaaa ttctgatcta attatgaatt taattactta tactattacc
    18061 gaataattaa agataaggtg atatataaga tgaaaattga agtgaaaaat atttctaaga
    18121 aataccagga tagagaagta ttaaaggatg taagctttac gattgaaaaa ggtactattt
    18181 gtggtttatt tgggatgaat ggtgttggaa aatcaacttt aatgaaaatt atttatggga
    18241 ttgaaatacc agataaagga caagtactat ttgaaggtca cggaaaaact agtaacattg
    18301 gtgctttgat tgaacaacca ccaatttatt cgaatttatc agcttttgat aatttaaaaa
    18361 ctaaagcact tttatatgat attccaaata atcaaattaa agatgtttta aaaagagttg
    18421 gtttagatag cacggataaa aaacatgcag gtaaattttc agttggcatg aaacaaagat
    18481 tggggatcgg aatggctatt ttaacacaac ctaaatttat aattctcgat gaaccaatta
    18541 acggattaga tcctgatggg gttattgaat ttttagattt actaaagtca ttaaaaaaac
    18601 aaggtgtaac tattttgata tcaagtcacc agctacatga aattggaaga atcgtcgatc
    18661 aagttatcat tttagataaa ggacatgttg tatatgataa aattcaaagt aattataaag
    18721 atattgaaga gattttcttt aatgttatga agggagagag tttcatatga taaaagcttt
    18781 gttttctgaa atattgaaat taaaaaaagt tagaataaac aaacttttat ggatcatccc
    18841 tttattaacg ggtttaattg cttttttagt agggggagta attatttttt ctccttttgc
    18901 catatattgg tgggaatctg tttttttata cctactaata ggattattat ttttaatgga
    18961 ttttaatatg gagaaaaaag caggaaactt tcaaaatgtt aagtataatt tgtggagttt
    19021 ccaaatttat ttggcaaaaa ttttcttaat ctttgtacga gttgcaatat caagtctttt
    19081 ttttataata ctagtaattg tcttaaataa gttttttagt ggttatacag aattattact
    19141 aagtaaaagt atactaagta tatttctgtt attgttatct gtattttgga atataccgtg
    19201 gttatatttt ttagctaatt ttataaatgg ctatttgctt atagcagtta atacgttagt
    19261 atgtttatta tttggatcta tcatttctca aacacaatgg tggtttgcat ttccatactc
    19321 gtaccattat aaaatatcac agtatctatt aggggtacag ccctcaggaa tttttaaaat
    19381 tataaattta caactttttg atgttatgag tcctgtatta ctttcattat tgatatcttt
    19441 acttttaata tattttacaa gatggggtaa atcaaatgat tagaagtgaa ttattaaaat
    19501 taaaaagtag tcctactata tacctattag taagtttcac tatttttgaa attgcatcag
    19561 cctacgggta tttgtattgg catcgaaatt tactaactta taaaaatatt gtactggcat
    19621 ttgctctagc ttatccatct ttaatttctg tgataactaa tatatgcttt gaacaagaaa
    19681 gagaagcaaa taattttcaa gaagttcgta agtatagtca agtgaaatta cttacaataa
    19741 aaacgttaat cttagactta ttattatggt ggatttcatt ttttgtatgg tggataataa
    19801 gttattccat agcccaagtt aaattaggga taatcagcgg aatagcaatg tggctattga
    19861 tagtattact taatcatagt cacatgtttt tatatatggt tactaataaa tatataaatt
    19921 tagtattttc attagtagag attttattta ttatttttgc tagtaataaa actttaatgt
    19981 cagcctattg gtgtttcgta gcatggccta ttaactattt gattcatgca gataatagta
    20041 aactttattt tagtgcaatg tggattttga tattaacaat tttagattat ttcatcttta
    20101 gaagtataga attagaaaga atagactgat attttggggt gatgaaaagc taattttgaa
    20161 tattagacac aggagaaatt ctaaaattta tgcaaataaa gcgatatcaa agtttatttt
    20221 gcataaatta agaaattggt cctatgtcga aatcgcccaa attaacctaa cagtttatag
    20281 tttaatgacc taagctttgt tagtatataa gtgtaccgat gaagctagtg gatgaggtgt
    20341 gacaagccgc ctagccatac gtctcttaat aactactatg acgaaatata cggatacgtt
    20401 tattttttct aatgtactaa ttgggagcaa cgaaaaaagt tgtgtagaga gaagcaaggg
    20461 gactcatatc tgaaactaag acacttgccg tcagggattc gcaatatgcc atcttcagtt
    20521 aattaaggct gattacctta ggaaccaaag aagaatatca actaagaatt cgtgtcgtga
    20581 agttgtggtg acacagctat aactgacgag taaggtttga gtagccaaaa tcgacaatat
    20641 tacattaact ggaacattgc acatgtttgg tgaaaattgg ataggaaaag gtctatgccc
    20701 tgaacttgaa atgcggacta ggtcatggaa gttgctagcc atgatgtgct agtctgattc
    20761 agtagtctaa taagtccaga tacaagagta tcccacgtaa gccaatacgc gtcggtttac
    20821 ataattttta gtcaatgcaa attttgcgtt ggctattttt ggtattaaat gttcgaggta
    20881 tgtataatta aattgaggtg atttcatgaa gccaatgtat gtttcgataa attcagaaaa
    20941 aactggtgct aatctaaaaa gtttattcaa aaataatggg tacagtgtac gtgatattca
    21001 atcagttatg ggatttgaga acccacaatc catttataaa tggttatctg gtagatcact
    21061 acctagtttg gataacttag tcattctcag taaggttcta cataccacaa tcgaagacat
    21121 cctcgttgtt gacggggatg ttgttttttt attcaattta acttggacta tacagttaaa
    21181 tagataataa ttgaaaggaa acataaaaat gcaagaagtc atgagctata gaggttacaa
    21241 aggaacaata gagtattctt tagaggataa tattttacat ggcgaagttt tggggattag
    21301 aagtttatta tcctatgaag gaaatacatt acaagaattg aaagatgatt ttgaagatac
    21361 aattgatgat tattttgagt gttgcaaaaa tcacaatatg actcctgaaa aaccttacaa
    21421 gcagaacatt gtaattaact tagaaccaga tttgtaagaa aaattatatt tatattctga
    21481 acttcgtgat gaagatattt ctgacagtat aaatagagcg attagaaatt tggtcgacaa
    21541 ataggatgta tacttttacg gaaagtgatg tattatgaaa aaaagtagag ttaataagat
    21601 taagatagaa tctaaaaaag ctttagttgt gcgtagatta gattggaggg ccccttcttc
    21661 taggataaat tattctatct tagagatgat agatgattta aatgattcta aattagaacg
    21721 agcaagcaat ttagctgaat tagagagttt attaaataag taatattatt tttaccaaaa
    21781 attagaaaat acaaacttat aattaaaatt tattgacaaa agtatagtaa ggttatatga
    21841 tttggttaaa gaaatgagag gagtgtgaat cactatgtca aactttatca atacacaatg
    21901 ctgttgtttg gtaacatgtt gtccagtagg aaacatgggt tttggcatgc agaaaattag
    21961 attcacactt ccaagattgg attaaactgt atatatttat tatcggtacc gatgcagatt
    22021 aatttaatca gttagattat atgagataat aataactgga cttgcgattc taattttttg
    22081 gagttgcaag tcctttttgt ttatttggaa ggatggatga tgaactgttt atagattaaa
    22141 aaacatattt tacataaagg ggaaaataaa gatgaaaaga attaaagcaa ttattactgg
    22201 aatatttata agcttaaccg caattttgtt agttgcatgt ggtaaatcaa ctggtgaaaa
    22261 ttctaaacaa gttttaaatc taagtacaac tggaccattg gataccattg atatttctaa
    22321 gtctacaggt tatggtcaaa ctgggaatgt ttttgaaagt ttttatcgtt taggtaaaga
    22381 tggcaaggta actcctggat tagctaaaag tggtcaagtt tcacaagatg gcaaaacatg
    22441 gacttttact ttgagagatg caaagtggag taatggagat aagattactg ctcaagattt
    22501 tgtatattct tggaaaagaa caattgatcc taagacagct tcaccatatg cttatttgtt
    22561 ctatgatgta aagaatgccc aagctatcaa tgaaggtaaa atgtcagctg ataaattagg
    22621 aataaaggct gaaggtgata ataaggttgt tattacgtta gatagaccta tatcatattt
    22681 taaagtctta atgacatatc cattatttgg accacaaagt gaaaaagtgg tacaaaagta
    22741 tggtaagaaa tatggaacta attctaaata catggtgtac tcaggaccat ttaaagttaa
    22801 agactggaat ggtacttcgg ataagtggtc atttgtaaag aataatcaat attgggataa
    22861 aaaagtggta aaactacaaa agattaacta tcaagtagtt aaaaatacca atacaggtta
    22921 tcaattattc caacaaggta agttagattt aacaccatta tctagtgaac aagttaagaa
    22981 tctacataac aagccagaat tcaagcaata ctcttattct tacgttgcat atttagacta
    23041 taactttaat gattctaatg aagtaaatcg taaggcacta aataataaaa atattagatt
    23101 agctttatca ttagcgattg acagaaagac acttacaaag aaagttttcg gcgatggatc
    23161 taatgtacca actggttttg tagcatctga tttagctact aatccaaaaa caggtaaaga
    23221 tttcgctgca gaacaaaaag tagataatac agttgattac aatgagaaat tagctagaga
    23281 atattggaaa aaaggattac aagaaattgg tgaaaagaat ttgaatttca caattctagc
    23341 ttccaatgaa atggctaata atgatgcttt aactcaatat ctacaatcac aatatacaaa
    23401 ggtattgcca ggaattaagg tttccgtaca aaatattcct ggaaatagcg cattatctaa
    23461 agctcgtaaa ggtaactatg acatttatgt atctggttgg ggtggagact ttaaagatcc
    23521 aatcactttc atgcaaattc cagttacagg aacttcatac aattatggaa agtactctaa
    23581 taaagagtac gatgctttaa ttgaaaaagc acaaaatgaa gatgccaatg atgctaataa
    23641 acgttgggaa gatttagtta aagctgctcg actctttaat gctgatcaag gggtaacacc
    23701 tctatatcaa caaacaacat cttatatgca aaataccaaa gtaaagggta ttattcaaaa
    23761 tactgcaggt acacaatgga actacaaata cgcttatatt aaataggtaa gaactcgtct
    23821 agaatgattt ctaggcgagt ttttaagttg tgctaaataa tttgcataag agtattgatt
    23881 atgttgtatg taagcgttat tctatatttg taaacttatt ataaagatta ttacttaatt
    23941 acaaataaat ttaaggatat atattgtaaa aatacttaaa tctaatcgtt atgttgagta
    24001 atttgtctta taattattat tgataagaaa attccaggaa aggtaactat tttatagtgg
    24061 tgatttaaat gtcagtatta gaagttaaag atttacatgt aactgttgaa ggaaagaaaa
    24121 tattgaaagg tgttaatttg aagatgtcaa ctggtgagat tcatgcaatc atgggtccaa
    24181 acggtaccgg gaaatcaaca ctttcttcaa ctattatggg cgatcctgct tataagatta
    24241 ctaaagggga tattttgtta aatggtaaaa gcattattga tttaccggtt gatgaacgtg
    24301 ctagaatggg actattttta gcaatgcaat atccacaaga aattccagga gtaactaatg
    24361 cagaatttgt taagagtgca attaatgctc gtcgtcctaa agatgatcca attcctttaa
    24421 tggacttcat caaacgtttg gatgaaactt tagaaacatt ggatatgtct gaagaaatgg
    24481 ctgacagata tttgaatgaa ggcttttctg gtggtgaaaa gaaacgtaat gaaattatgc
    24541 aaatgatgat gatcagacct gaattcgcaa ttttagatga aatcgactct ggactagata
    24601 ttgatgctct taaggttgtt tctcgtgggg ttaaccaaat gcgtggcgat aattttggat
    24661 ccttgatcat tactcactat caaagacttt taaactatat tattccagat tatgtacatg
    24721 ttatgatgga cggtcgtctt gttaaaactg gtggtccaga tttggcaatc cgtttggaaa
    24781 aagaaggata tgcaaaactt cgtgatgaac ttggtttaga tattaaatta gttgatgaaa
    24841 atgcttaggg ggcttgtaca atgaaacaac tatccataga tgaattaatt gaacttcgaa
    24901 aagagcccga atggtttaaa gctaagcgaa atgaagctaa gcaactaatt gaaactacta
    24961 aattacctag tttccaaaag attaaatatc atgattggaa cataaatgtt gatggaacaa
    25021 ctgcaattga taatcaacct gaatttgata ccaatgctga tgtttatcaa tatgcaagtg
    25081 acaaagcaca aattaaacta ccacaagaat ttcttgataa gggagtaatt gttgaagatt
    25141 ttgaggatgc tctggttaac catgaagata ttatgaagaa atactttatg gaaaaaggac
    25201 taaaaatgga cgataatcgt ctattagcag aacatgtagc aaatcttcaa agtggtgttt
    25261 tagtctatgt acctaaaaat gtagatttag aaacaccatt aacttgtgaa tatatccaaa
    25321 attcacgagt tgaaggagat tatgttcatc atgtattaat tgttacggaa gcaaatagtt
    25381 cgctatctta tgtagaacgt ttaaaaactg atggtgataa gagtaataca gccaatattg
    25441 tagttgaagt tattgccggt aatggaagtc gcattcactt tgctagtgtt gataatttaa
    25501 gtaagaacac aactgcctat atgaatcgtc gtggatactt acaaagagac tctaagattg
    25561 actgggcaat gggtatgatg aattctggtt taacaatcgg tgattttgat tctgatttag
    25621 ttggcgatgg ctctcatgct gaattaaaag tcgtaggtat ttcaacaagt gatcaaattc
    25681 aaggaatcga tacacgagtt acaaatattg gaaagaatac gatcggccat atcttacaac
    25741 atggtgttgc tttagatgca tccgaactaa ctttcaacgg cattggacat gtaatgaaga
    25801 gaagtaaagg ttctgatgca caacaagaaa gtcgtatttt aatgttatct ccacaagcta
    25861 gaggggatgc taatccaatc ttactaattg atgataatga tgttactgca ggacatgcgg
    25921 caagtattgg tcgtgtaaat cctgaacaat tgtactactt aatgagt
//
