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Overview
1.1
2.1
2.2

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP090411.1 (Ligilactobacillus salivarius)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | T3PKS,terpene-precursor | 576,786 | 617,949 |

NZ_CP090412.1 (Ligilactobacillus salivarius)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 2.1 | RiPP-like | 69,510 | 79,928 | Medium | salivaricin CRL1328 α peptide/salivaricin CRL1328 β peptide | ribosomal:RiPP
Region 2.2 | lanthipeptide-class-i | 92,837 | 118,803 | Medium | nisin Q | ribosomal:RiPP:Lanthipeptide

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | T3PKS,terpene-precursor | 576,786 | 617,949 |
Region 2.1 | RiPP-like | 69,510 | 79,928 | Medium | salivaricin CRL1328 α peptide/salivaricin CRL1328 β peptide | ribosomal:RiPP
Region 2.2 | lanthipeptide-class-i | 92,837 | 118,803 | Medium | nisin Q | ribosomal:RiPP:Lanthipeptide

No secondary metabolite regions were found in these records:
  NZ_CP090413.1 (Ligilactobacillus salivarius)

Compact view
NZ_CP090411.1 - Region 1 - T3PKS,terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 576,786 - 617,949 nt. (total: 41,164 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: lyase
LZF92_RS03120: argininosuccinate lyase/adenylosuccinate lyase

smcogs
  SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Ligases: synthase synthetase
LZF92_RS03155: hydroxymethylglutaryl-CoA synthase

smcogs
  SMCOG1043: hydroxymethylglutaryl-CoA synthase

LZF92_RS03205: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002397.2 |  |  | 0.41 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  |  | 0.37 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  |  | 0.28 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000639.3 |  |  | 0.22 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0002561.3 |  |  | 0.22 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0000642.3 |  |  | 0.21 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000638.3 |  |  | 0.21 | terpene | carotenoid | Pantoea ananatis
BGC0000286.3 |  |  | 0.20 | PKS | viguiepinol | Streptomyces sp. KO-3988
BGC0001605.3 |  |  | 0.19 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0001859.4 |  |  | 0.19 | other (phosphonate) | fosfomycin | Pseudomonas syringae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.53 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.50 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.44 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000639.3 |  | 0.40 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0002561.3 |  | 0.40 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0000642.3 |  | 0.40 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000638.3 |  | 0.40 | terpene | carotenoid | Pantoea ananatis
BGC0000286.3 |  | 0.38 | PKS | viguiepinol | Streptomyces sp. KO-3988
BGC0001605.3 |  | 0.38 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000665.5 |  | 0.36 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
LZF92_RS03205: PT_FPPS_like
Domain 1 (42 - 301): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  IPP, DMAPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.66 out of 25.88
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.18 out of 26.06
Confidence: strong
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.14 out of 25.88
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.41 out of 20.97
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.17 out of 24.78
Confidence: medium
Additional weak hits (6):
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 16.71 out of 20.47
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12
Confidence: weak
CsoR
Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 23.18 out of 32.38
Confidence: weak
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 16.61 out of 20.47
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.60 out of 35.63
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
PsrA | Oleic acid responsive regulator

NZ_CP090412.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 69,510 - 79,928 nt. (total: 10,419 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: hydrolase
LZF92_RS09720: HAD-superfamily hydrolase, subfamily IA, variant

smcogs
  SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000624.3 |  | 0.60 | ribosomal | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0001388.3 |  | 0.49 | ribosomal | gassericin E | Lactobacillus gasseri
BGC0000619.3 |  | 0.49 | ribosomal | gassericin T | Lactobacillus gasseri
BGC0001602.3 |  | 0.49 | ribosomal | gassericin-T | Lactobacillus gasseri
BGC0002579.2 |  | 0.40 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0000498.5 |  | 0.29 | ribosomal | bovicin HJ50 | Streptococcus equinus
BGC0000561.5 |  | 0.29 | ribosomal | thermophilin 1277 | Streptococcus thermophilus
BGC0001728.4 |  | 0.19 | NRPS, PKS | paenilipoheptin | Paenibacillus polymyxa E681

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000624.3 |  | 0.60 | ribosomal | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0001388.3 |  | 0.49 | ribosomal | gassericin E | Lactobacillus gasseri
BGC0000619.3 |  | 0.49 | ribosomal | gassericin T | Lactobacillus gasseri
BGC0001602.3 |  | 0.49 | ribosomal | gassericin-T | Lactobacillus gasseri
BGC0002579.2 |  | 0.40 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0000498.5 |  | 0.29 | ribosomal | bovicin HJ50 | Streptococcus equinus
BGC0000561.5 |  | 0.29 | ribosomal | thermophilin 1277 | Streptococcus thermophilus
BGC0001728.4 |  | 0.19 | NRPS, PKS | paenilipoheptin | Paenibacillus polymyxa E681

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.77 out of 27.78
Confidence: medium
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.94 out of 18.46
Confidence: medium
Additional weak hits (2):
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 27.54 out of 39.62
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.50 out of 36.54
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
RpoN | Regulator of nitrogen assimilation and virulence

NZ_CP090412.1 - Region 2 - lanthipeptide-class-i
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 92,837 - 118,803 nt. (total: 25,967 nt) Show pHMM detection rules used
lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
LZF92_RS09845: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

LZF92_RS09880: dehydrogenase

smcogs
  SMCOG1072: dehydrogenase

Lyases: cyclase dehydratase
LZF92_RS09895: Lantibiotic dehydratase domain protein

smcogs
  SMCOG1155: Lantibiotic dehydratase domain protein

LZF92_RS09905: Lanthionine synthetase C family protein

smcogs
  SMCOG1140: Lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-i | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000538.3 |  | 0.71 | ribosomal | nisin Z | Lactococcus lactis
BGC0001789.3 |  | 0.71 | ribosomal | suicin 90-1330 | Streptococcus suis
BGC0000535.4 |  | 0.70 | ribosomal | nisin A | Lactococcus lactis subsp. lactis
BGC0000536.3 |  | 0.70 | ribosomal | nisin Q | Lactococcus lactis
BGC0000537.3 |  | 0.68 | ribosomal | nisin U | Streptococcus uberis
BGC0000549.3 |  | 0.59 | ribosomal | salivaricin D | Streptococcus salivarius
BGC0000515.4 |  | 0.57 | ribosomal | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0001289.5 |  | 0.57 | ribosomal | penisin | Paenibacillus ehimensis
BGC0002323.2 |  | 0.56 | ribosomal | nisin J | Staphylococcus capitis
BGC0000556.5 |  | 0.55 | ribosomal | streptin | Streptococcus pyogenes

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000538.3 |  | 0.71 | ribosomal | nisin Z | Lactococcus lactis
BGC0001789.3 |  | 0.71 | ribosomal | suicin 90-1330 | Streptococcus suis
BGC0000535.4 |  | 0.70 | ribosomal | nisin A | Lactococcus lactis subsp. lactis
BGC0000536.3 |  | 0.70 | ribosomal | nisin Q | Lactococcus lactis
BGC0000537.3 |  | 0.68 | ribosomal | nisin U | Streptococcus uberis
BGC0000549.3 |  | 0.59 | ribosomal | salivaricin D | Streptococcus salivarius
BGC0000515.4 |  | 0.57 | ribosomal | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0001289.5 |  | 0.57 | ribosomal | penisin | Paenibacillus ehimensis
BGC0002323.2 |  | 0.56 | ribosomal | nisin J | Staphylococcus capitis
BGC0000556.5 |  | 0.55 | ribosomal | streptin | Streptococcus pyogenes

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for LZF92_RS09895

LZF92_RS09890
Leader:
MSVNDFKLDLVKVSKESTNSNYSVK
Core:
I T S Y S L C T P G C K T G A L M G C T M K T A S C G C H V H I S K
Core with dehydrations:
I Dhb Dha Y Dha L Cys Dhb P G Cys K Dhb G A L M G Cys Dhb M K Dhb A Dha Cys G Cys H V H I Dha K

#### antiSMASH-DB 4.0 matches for LZF92_RS09890

100.0%
NZ_CP090412.1 and 3 others:
NZ_QSTB01000004.1 Lanthipeptides: DXC22_RS03785_lanthipeptide NZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptide NZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptide
Lanthipeptides: LZF92_RS09890_lanthipeptide
1
I T S Y S L C T P G C K T G A L M G C T M K T A S C G C H V H I S K
34
I T S Y S L C T P G C K T G A L M G C T M K T A S C G C H V H I S K
1
I T S Y S L C T P G C K T G A L M G C T M K T A S C G C H V H I S K
34
91.2%
NZ_FBTD01000003.1:
Lanthipeptides: PB1E_RS03075_lanthipeptide
1
I T S Y S L C T P G C K T G A L M G C T M K T A S C G C H V H I S K
34
I T S S L C T P G C K T G A L M G C M K T A S C G C H V H+S K
1
I T S V S L C T P G C K T G A L M G C N M K T A S C G C H V H V S K
34
79.4%
NC_013656.1 and 18 others:
NC_020450.1 Lanthipeptides: LILO_RS03015_lanthipeptide NZ_CP009472.1 Lanthipeptides: LG36_RS03420_lanthipeptide NZ_CP010050.1 Lanthipeptides: QI18_RS03300_lanthipeptide NZ_CP015903.1 Lanthipeptides: LLUC08_RS03255_lanthipeptide NZ_CP024954.1 Lanthipeptides: CV702_RS02990_lanthipeptide NZ_CP066300.1 Lanthipeptides: LacL0098_RS03205_lanthipeptide NZ_CP098790.1 Lanthipeptides: M5C73_RS03405_lanthipeptide NZ_JAALEQ010000006.1 Lanthipeptides: HFD15_RS10120_lanthipeptide NZ_JAJONJ010000005.1 Lanthipeptides: LSG16_RS07195_lanthipeptide NZ_JAQDWM010000007.1 Lanthipeptides: PGU01_RS08180_lanthipeptide NZ_JAQDXV010000018.1 Lanthipeptides: PGT80_RS11850_lanthipeptide NZ_JAQEIZ010000019.1 Lanthipeptides: PGX18_RS12025_lanthipeptide NZ_JAQEOU010000022.1 Lanthipeptides: PGV42_RS12330_lanthipeptide NZ_JAQEOV010000015.1 Lanthipeptides: PGW09_RS10765_lanthipeptide NZ_MTJP01000006.1 Lanthipeptides: BW151_RS03795_lanthipeptide NZ_MTJR01000005.1 Lanthipeptides: BW153_RS02980_lanthipeptide NZ_MTJS01000002.1 Lanthipeptides: BW154_RS09850_lanthipeptide NZ_RAGL01000022.1 Lanthipeptides: D6108_RS11395_lanthipeptide
Lanthipeptides: LLKF_RS13210_lanthipeptide
1
I T S Y S L C T P G C K T G A L M G C T M K T A S C G C H V H I S K
34
I T S S L C T P G C K T G A L M G C M K T A+C C +H+S K
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S K
34
with 127 more sequence matches
Only the first 10 are displayed here.
79.4%
NZ_CP065984.1 and 2 others:
NZ_CP095737.1 Lanthipeptides: MXM90_RS03205_lanthipeptide NZ_JAQDXJ010000021.1 Lanthipeptides: PGU19_RS11740_lanthipeptide
Lanthipeptides: I6I21_RS02785_lanthipeptide
1
I T S Y S L C T P G C K T G A L M G C T M K T A S C G C H V H I S K
34
I T S S L C T P G C K T G A L M G C M K T A+C C +H+S K
1
I T S I S L C T P G C K T G A L M G C N M K T A T C H C S I H V S K
34
76.5%
NZ_JAQDYA010000007.1 and 1 other:
NZ_JAQDYA010000007.1 Lanthipeptides: PGT72_RS09560_lanthipeptide
Lanthipeptides: PGT72_RS09560_lanthipeptide
1
I T S Y S L C T P G C K T G A L M G C T M K T A S C G C H V H I S K
34
I T S S L C T P G C K T G A L M G C M K T A+C C +H+S+
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S R
34
73.5%
NZ_LR793265.1:
Lanthipeptides: HV392_RS09825_lanthipeptide
1
I T S Y S L C T P G C K T G A L M G C T M K T A S C G C H V H I S K
34
I T S Y S L C T P G C T G L M G C ++A C H V H I S K
1
I T S Y S L C T P G C I T G R L M G C Q F Q S A G C N V H V H I S K
34
70.6%
NC_022237.1 and 1 other:
NZ_JUZI01000019.1 Lanthipeptides: ADI02_RS09325_lanthipeptide
Lanthipeptides: SII_RS05025_lanthipeptide
1
I T S Y S L C T P G C K T G A L M G C T M K T A S C G C H V H I S K
34
+T S +C T P G C T G A L M G C ++T A+C C H V H I S K
1
V T S V F M C T P G C V T G A L M G C N L Q T A T C N C H V H I S K
34
70.6%
NZ_CP059471.1 and 3 others:
NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptide NZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptide NZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide
Lanthipeptides: H1R75_RS06635_lanthipeptide
1
I T S Y S L C T P G C K T G A L M G C T M K T A S C G C H V
30
I T S S L C T P G C K T G A L M C +K T A+C G C H
1
I T S K S L C T P G C K T G A L M T C P I K T A T C G C H F
30
70.6%
NZ_JADNFO010000025.1:
Lanthipeptides: I2C89_RS09745_lanthipeptide
1
I T S Y S L C T P G C K T G A L M G C T M K T A S C G C H V H I S K
34
I T S Y S L C T P G C K T G L M C +K T A+C C + +S K
1
I T S Y S L C T P G C K T G V L M A C H L K T A T C N C S I I V S K
34
70.6%
NZ_LR793265.1:
Lanthipeptides: HV392_RS09830_lanthipeptide
1
I T S Y S L C T P G C K T G A L M G C T M K T A S C G C H V H I S K
34
I T S Y S L C T P G C T G L M G C ++A C H V H+S K
1
I T S Y S L C T P G C I T G V L M G C Q F Q S A G C N V H V H V S K
34
67.6%
NZ_CP009913.1 and 1 other:
NZ_CP009913.1 Lanthipeptides: SSAL8618_RS00810_lanthipeptide
Lanthipeptides: SSAL8618_RS00815_lanthipeptide
1
I T S Y S L C T P G C K T G A L M G C T M K T A S C G C H V H I S K
34
I T S Y S L C T P G C T G L M G C +++ C H V H+S K
1
I T S Y S L C T P G C I T G V L M G C H I Q S I G C N V H V H V S K
34
65.7%
NZ_CP013655.1 and 2 others:
NZ_CP013655.1 Lanthipeptides: ATZ35_RS03635_lanthipeptide NZ_CP013655.1 Lanthipeptides: ATZ35_RS03630_lanthipeptide
Lanthipeptides: ATZ35_RS03640_lanthipeptide
1
I T S Y S L C T P G C K T G A L M G C T M K T A S C G C H V H I S K
34
I T S S L C T P G C T G L M G C +K T +C C V I K
1
I T S K S L C T P G C V T G V L M G C A L K T I T C N C S V G I G K
34
65.7%
NZ_FNDP01000013.1:
Lanthipeptides: BLP54_RS11230_lanthipeptide
1
I T S Y S L C T P G C K T G A L M G C T M K T A S C G C H V H I
32
I T S S L C T P G C T G L M G C K T A+C C V H+
3
I T S K S L C T P G C V T G V L M G C N N K T A T C N C S V H V
34

#### MIBiG 4.0 matches for LZF92_RS09890

79.4%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
1
I T S Y S L C T P G C K T G A L M G C T M K T A S C G C H V H I S K
34
I T S S L C T P G C K T G A L M G C M K T A+C C +H+S K
1
I T S I S L C T P G C K T G A L M G C N M K T A T C H C S I H V S K
34
14.7%
BGC0002130.3 (QKI29070.1):
Lanthipeptide: cacaoidin
23
T A S C G C
28
T A S G C
18
T A S W G C
23

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.77 out of 23.79
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.85 out of 23.79
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 14.86 out of 18.16
Confidence: strong
Additional weak hits (6):
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.45 out of 30.22
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.61 out of 30.22
Confidence: weak
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.20 out of 19.52
Confidence: weak
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.28 out of 29.72
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.38 out of 39.62
Confidence: weak
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.04 out of 20.47
Confidence: weak
Lanthipeptides
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

LZF92_RS09890 - Class I
  Cleavage pHMM score: 12.40
  RODEO score: 26
  Monoisotopic mass: 3326.6 Da
  Molecular weight: 3329.0 Da
  Number of bridges: 5
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3347.0 Da N = 1
    3365.0 Da N = 2
    3383.0 Da N = 3
    3401.1 Da N = 4

RRE predictions
RREfinder results sidepanel.

lanthipeptide-class-i protocluster (92836...118803)
LZF92_RS09895
  RRE type: Lanthipeptide_LanB_RRE
  Location: 141 - 226
  Score: 38.1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
IolR | Regulator of the inositol catabolism