LOCUS       NZ_CP085300            21320 bp    DNA     linear   CON 18-JAN-2024
DEFINITION  Streptomyces sp. BSE6.1 chromosome, complete genome.
ACCESSION   NZ_CP085300
VERSION     NZ_CP085300.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. BSE6.1
  ORGANISM  Streptomyces sp. BSE6.1
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8024389)
  AUTHORS   Ramesh,C., Anwesh,M., Vinithkumar,N.V., Kirubagaran,R. and
            Dufosse,L.
  TITLE     Complete Genome Analysis of Undecylprodigiosin Pigment
            Biosynthesizing Marine Streptomyces Species Displaying Potential
            Bioactive Applications
  JOURNAL   Microorganisms 9 (11), 2249 (2021)
   PUBMED   34835376
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8024389)
  AUTHORS   Chatragadda,R. and Maile,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-OCT-2021) Andaman and Nicobar Centre for Ocean Science
            and Technology, National Institute of Ocean Technology, Dollygunj,
            Port Blair, Andaman and Nicobar Islands 744103, India
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 10-OCT-2021
            Assembly Method                   :: Unicycler v. 0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/18/2024 07:10:02
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,273
            CDSs (total)                      :: 7,198
            Genes (coding)                    :: 7,094
            CDSs (with protein)               :: 7,094
            Genes (RNA)                       :: 75
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 104
            CDSs (without protein)            :: 104
            Pseudo Genes (ambiguous residues) :: 0 of 104
            Pseudo Genes (frameshifted)       :: 47 of 104
            Pseudo Genes (incomplete)         :: 80 of 104
            Pseudo Genes (internal stop)      :: 9 of 104
            Pseudo Genes (multiple problems)  :: 30 of 104
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:03:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2994251
            Orig. end                         :: 3015571
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP085300.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from National Institute of Ocean
            Technology.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21320
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="18"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..21320
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21320
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11320](-)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11320)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     misc_feature    82..95
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.49"
                     /tool="antismash"
     gene            complement(368..1120)
                     /locus_tag="LJA35_RS13010"
     CDS             complement(368..1120)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003998196.1"
                     /locus_tag="LJA35_RS13010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_102930880.1"
                     /transl_table=11
                     /translation="MTFGEQPAYLRVAGDLRKKIADGLLPPHTRLPSQARIREEYGVSD
                     TVALEARKVLMAEGLVEGRSGSGTYVRERPVPRRVARSGYRPAGGATPFRQEQADADAR
                     GTWESRSEQAEASGAVAERLGIEPGDRVMCTRYVFREAGEAVMLSTSWEPLDLTGRTPV
                     MLPEEGPLGGMGVVERMAAIDVVVDNVTEEVGARPGLAEELLALGGVPGHVVLVVQRTF
                     YASGRAVETADVVVPADRYRVAYHLPVR"
     misc_feature    complement(1133..1151)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.0"
                     /tool="antismash"
     gene            complement(1268..2302)
                     /locus_tag="LJA35_RS13015"
     CDS             complement(1268..2302)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444325.1"
                     /locus_tag="LJA35_RS13015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4190 domain-containing protein"
                     /protein_id="WP_325176508.1"
                     /transl_table=11
                     /translation="MNGLAVAAFVLGVLCFVPAVGLVLGLIALAGIRKRGERGKGFALA
                     GCVLSSVGLALWVLTLSTGAAADFWDGFKDAARGEGTAYALEKGQCFTTPGGSLEGVTY
                     DVDVVPCEGAHDGEVFAVFDMPGSGSYPGDHAVTEAADARCYGLVDGYVMDTWALPADV
                     DVYYLTPTARSWLSGDREVSCLFGSTDEGASLTGSLRNDGTTLDAHQLAYLKAARVLDA
                     ALESTPENEYFEDDPIAQQSWAGRVENALTEEIGMLGAHSWPSASERQVTELVADLEAA
                     REEFAAAEVASEADAFYEHLYQGYGLIDGDTTVTARESLGLASTPPDYEESGDGGGESP
                     GKEV"
     gene            2844..4994
                     /locus_tag="LJA35_RS13020"
     CDS             2844..4994
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024753.4"
                     /locus_tag="LJA35_RS13020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PQQ-binding-like beta-propeller repeat protein"
                     /protein_id="WP_233645767.1"
                     /transl_table=11
                     /translation="MSKPSVLGVMLGAPLTAGGAHYGATEGPAGFVAALVGAVLLTAGV
                     LGYRRVLVLRRRLRSLMPAAQRSPVAHLPSARRAATLAAYVNGVLVLLGLGGAGWLLYM
                     GASWGAYDNSFGFAALVMGALLPFALGLAAASTVPELLRVVPAGARMGQALYGVFVCVA
                     SLMIAKGDGLLPRLVGAVIAVLALGAIALLGRCFRVMGGAAPRQGSGSPGAGQPGPGQP
                     GFGPPGPGQPGFGQPAPAPGFGPPTSPPGGPHGPAPYGPPAPRAGRGGLVLVLVLVLVA
                     VLGGGGLYAVKEAGLLDGDDSTTTDVAESPQAPAYGVGGERRARWATGAPAPEGTAPEY
                     LVGGDEDVVVHVTGTLVTGYDVATGKKLWDVEDRSGDFRTCAVSPTAVGHVVAVLMRRG
                     DQGPCGFLVAVDVRRGKQLWSKGILGEGSGAGMGTATVRVTANSVVSGTQTAPVVLDAR
                     SGDVRWTGADQPDEDGEARSLRGLEVAGNSLVASYGDGLGGSTALRRFDLRSGRVTARP
                     SPPKAPETPTPKDVLSVLSVEPLVVSLGDDTNADRFYFSRVGDAWKPLRTDAVEGVSAR
                     SGPQEGMVTDGLFVKAFTTDDRSLDVGFDTVVAAFDLESGALRWQHALHRDAGQVVLLP
                     GTVGGAVRAVASDHDTGDQLYAFPLEDGGPVRGGRLTVDASLSGAPSGLNDLTGAVVQG
                     ERLIVRSQVDGTLVAFPFPSKA"
     gene            complement(5028..5858)
                     /locus_tag="LJA35_RS13025"
     CDS             complement(5028..5858)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (3-155). E-value: 2.3e-10. Score:
                     32.6. Matches aSDomain:
                     nrpspksdomains_LJA35_RS13025_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020119688.1"
                     /locus_tag="LJA35_RS13025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="oxidoreductase"
                     /protein_id="WP_233645768.1"
                     /sec_met_domain="adh_short (E-value: 7.8e-32, bitscore:
                     109.4, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKVWLITGASSGFGRALAEAALADGDVVVGAARRPEALDDLVAA
                     HPDQMEALRLDVADTAAAEDAVRDVVGRYGRVDVLVNNAGRTHVGALEETGEDELRALF
                     DVHVFGPAALTRAVLPSMRERSSGAIVQMSSMGGQMSFAGFSAYSGTKFALEGMSEGLA
                     DEVRDFGVKVLIVEPGSFRTGLFQAGNAGISADSGVYAKVGETRGMIAGGDGSQPGDPA
                     RAAAVIRAALAAEHTPLRLPLGDDGVSAVLGHLDQVREDVEAWEKLTRATAFDG"
     aSDomain        complement(5394..5849)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_LJA35_RS13025_PKS_KR.1"
                     /evalue="2.30E-10"
                     /label="LJA35_RS13025_PKS_KR.1"
                     /locus_tag="LJA35_RS13025"
                     /protein_end="155"
                     /protein_start="3"
                     /score="32.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VWLITGASSGFGRALAEAALADGDVVVGAARRPEALDDLVAAHPD
                     QMEALRLDVADTAAAEDAVRDVVGRYGRVDVLVNNAGRTHVGALEETGEDELRALFDVH
                     VFGPAALTRAVLPSMRERSSGAIVQMSSMGGQMSFAGFSAYSGTKFAL"
     CDS_motif       complement(5799..5849)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_LJA35_RS13025_0001"
                     /evalue="1.30E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="LJA35_RS13025"
                     /protein_end="20"
                     /protein_start="3"
                     /score="11.5"
                     /tool="antismash"
                     /translation="VWLITGASSGFGRALAE"
     gene            5950..6864
                     /locus_tag="LJA35_RS13030"
     CDS             5950..6864
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444320.1"
                     /locus_tag="LJA35_RS13030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LysR substrate-binding domain-containing protein"
                     /protein_id="WP_233645769.1"
                     /transl_table=11
                     /translation="MTTDVHVRELRYFVTVAEELHFTRAAERLYVSQPALSKQVRALER
                     QLGAELFRRDPQGVALTEAGTALLPHARRVLADWAGGAAAVEAARAARRATLVVGMSTS
                     PGRGGLLPAIRSRFTAAHPEAVVRLRQMGWEDSTAGLADGTADVAYVWLPLPDAGRYAW
                     TVVAEEPRLVALPDDHPLASRPEVDFADLVAEPFLALPPEAGVLRDFWLALDERRALGA
                     GPARVGAEISGTEETYEALVAGLGICLVATGNAPLITLGGVTTRPVRGLTPSRYALAWR
                     REDEGRALVRDYAQACRRATAGG"
     gene            complement(6874..7461)
                     /locus_tag="LJA35_RS13035"
     CDS             complement(6874..7461)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014172653.1"
                     /locus_tag="LJA35_RS13035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_102930179.1"
                     /transl_table=11
                     /translation="MDAGTDEVDDVLDAVGPRLRALRRERGITLAHLSTATGVSESTLS
                     RLESGRRRATLELLLPLARIYGVPLDDLVGAPRTGDPRIHLKPVRRFGMVFVPLSRRPG
                     GTQAFKMIIPSRPAPLEPTPQTHEGSEWLYVLSGRLRLLVGERDLTLTPGEAAEFDTSL
                     PHWLGSADGGAVELLVLFGLQGVRAHVRDRGD"
     misc_feature    7477..7490
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.88"
                     /tool="antismash"
     gene            7575..8201
                     /locus_tag="LJA35_RS13040"
     CDS             7575..8201
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (34-138). E-value: 9.8e-09. Score:
                     25.6. Matches aSDomain: nrpspksdomains_LJA35_RS13040_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006131412.1"
                     /locus_tag="LJA35_RS13040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_212731099.1"
                     /transl_table=11
                     /translation="MSATDAVTFWDGVYAARPASDAPRPNVRLVEAVSDLSPGDALDLG
                     SGSGGDALWLARRGWRVTAVDVSGVAAERLAGHARALGLGDRVDAVRLDLRASFPEGRF
                     DLVCAHYLHTPFDLDRAAVLRTAAHALRPGGRLLVVDHGSTAPWSWDQDPDVRYPAPRE
                     VAAGLGLDPATWRVERAEAARRTATGPGGRTAEVVDHVLLVRRAG"
     aSDomain        7677..7988
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_LJA35_RS13040_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="9.80E-09"
                     /label="LJA35_RS13040_oMT.1"
                     /locus_tag="LJA35_RS13040"
                     /protein_end="138"
                     /protein_start="34"
                     /score="25.6"
                     /tool="antismash"
                     /translation="DLSPGDALDLGSGSGGDALWLARRGWRVTAVDVSGVAAERLAGHA
                     RALGLGDRVDAVRLDLRASFPEGRFDLVCAHYLHTPFDLDRAAVLRTAAHALRPGGRLL
                     "
     gene            8233..8721
                     /locus_tag="LJA35_RS13045"
     CDS             8233..8721
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444317.1"
                     /locus_tag="LJA35_RS13045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF664 domain-containing protein"
                     /protein_id="WP_233645770.1"
                     /transl_table=11
                     /translation="MSTTHRRDTPPPRTGNDEAATLRGFLDYLRTSIAGKVEGAPEPGV
                     RTAAVPSGTHLLGLLTHLTHVERAVFLGAEVRSWPATFRAAPQDGVAEVVARYREAVDD
                     ANRVLDTCTDLGAPLPRPRPGRPAPSVRWALTHMIEETGRHAGHSDILRELIDGTTGR"
     gene            complement(8754..10004)
                     /locus_tag="LJA35_RS13050"
     CDS             complement(8754..10004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019522324.1"
                     /locus_tag="LJA35_RS13050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_102930176.1"
                     /transl_table=11
                     /translation="MTDTAADDPPRIGPTTRVVLHDLAVRPDRDEWIVGRMATRTFVAL
                     PAAGARAVELLREGRSVTRTEETLRAETGEEFDIADFVGDLTALGFVARIGDRPVPDVE
                     PPRASLPWLRPRHVRLALHPVLPLLVGALLTAALVVLVRRPDLVPGYRDLLWSRHGSVV
                     LLSGAAAGWALLLAHELAHLVTARAAGVPGKMRLGTRLQFLVMQTDISGIELAPRRHRL
                     TAYLAGIALNLSVASSLVLVLAVTETGTTAHRLLAAALLLALLPLPFQCMVFTRTDLYF
                     VLQDLTGCRDLYGDGLAYARYRFRRAVRPVRRGPRAGAARDDPSARLPAHERRAVRIYS
                     VVLVVGTAACLTFMAAVTLPVDLALLARAVRGLGPEHGLAGNADAVTVLVVLGGVNVLW
                     LVTWWRNRRSRRAASAG"
     gene            complement(10001..11320)
                     /locus_tag="LJA35_RS13055"
     CDS             complement(10001..11320)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Pantocin_Microcin_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015658077.1"
                     /locus_tag="LJA35_RS13055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ThiF family adenylyltransferase"
                     /protein_id="WP_233645771.1"
                     /sec_met_domain="Pantocin_Microcin_RRE (E-value: 2.4e-25,
                     bitscore: 87.2, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="ThiF (E-value: 7.2e-39, bitscore: 132.3,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVHAMRLPRIKPEHRAYRTVDGHVRIGSVVHGIGAEVRDADGWV
                     WTLVQAMDGTRSATDVVAEVSRRHPELRLPAPDIAQAMTDLTDAGYVEDAGAEPPAELS
                     ERERERYSRSMTLLRWMDLRPRSSAWEPQLLLRRARVLLVGVGGTGSAAARDLVASGVG
                     RLHCVEPDVVELSNLNRQTLFHESDLGKPKLDAALTALRALNPDTEVTGERREVRGPAD
                     LEELLTGAGSRSRSRSRSSGTNGRRSPDSPVRAPGYDALLLAADRPAEIRRWANQICLS
                     TGTPWAEAGYRGPLVSVGVFTPGRGACWQCLRDAEVERRDLRLGPGQDEDVASPRMPWN
                     PANAVTAGLSGGLLAHAALMLLCGVPPVDPGCRFGLNLMLPGDPVLQRAQRRPDCPACR
                     RTEPDPVTGPVPDPVWEPVSDPVPDPLPAARAGSGDRDPS"
     aSDomain        complement(11018..11305)
                     /aSDomain="Pantocin_Microcin_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing E1-like protein in a
                     pantocin/microcin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_LJA35_RS13055_Pantocin_Microcin_RRE.1
                     "
                     /evalue="9.30E-28"
                     /identifier="RREFam017.1"
                     /label="LJA35_RS13055"
                     /locus_tag="LJA35_RS13055"
                     /protein_end="101"
                     /protein_start="5"
                     /score="87.2"
                     /tool="antismash"
                     /translation="MRLPRIKPEHRAYRTVDGHVRIGSVVHGIGAEVRDADGWVWTLVQ
                     AMDGTRSATDVVAEVSRRHPELRLPAPDIAQAMTDLTDAGYVEDAGAEPPA"
     misc_feature    complement(11286..11299)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     gene            11595..12890
                     /locus_tag="LJA35_RS13060"
     CDS             11595..12890
                     /GO_function="GO:0004181 - metallocarboxypeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007387607.1"
                     /locus_tag="LJA35_RS13060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="M14 family zinc carboxypeptidase"
                     /protein_id="WP_233645772.1"
                     /transl_table=11
                     /translation="MHRYPTVAEVTEAARRLVSRFPGACRLRRIGTSRAGRPLLMLSVG
                     HGPRHVLVVARPHPDEPVGGATALALAERVAAGDRCSPATDPDTVTWDIVLCLDPDGAA
                     LSEGIEAATAGPDPTLARYYRAAFRPVAAEQPEWAPIVGRRLPESRALFAVIDELRPVL
                     QCSLHNVDAGGTWVQLTGDLPGLAAPYAASASALGIPVQHGTYDALYWENPAPGIHILP
                     PPDSTARLAAGSENIALSTWCAPQRYGGVTAIVEVPLWATAPADDRTPHPGPARALRDL
                     SALVREGGRQVTAVFDKARDFLPPAEHSPPRRVLEWMADDLYDLVADAWQPLAEQARSA
                     SDSPAQTTAGISALEVVARRQPLRAAGLLLRLLDSTDDPASAALHHELDGLFTTWCTQF
                     EQSLHLRPVPVHAQVELQTHTVLAAAECALGR"
     gene            complement(13004..14023)
                     /locus_tag="LJA35_RS13065"
     CDS             complement(13004..14023)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005483106.1"
                     /locus_tag="LJA35_RS13065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_233645773.1"
                     /transl_table=11
                     /translation="MPDAAGETGEIVDVPGAADDYRVVIGEECFDWRELADPGLLGEAL
                     AALAEVLQPLADGRTTAFVDAAYDAECLPSTKLIDALYSPGSGLSHDDRIRLQKLLDKC
                     RVVEPVEADLPRPVRAADGLEREPSWGVAHALARAAGGRAMSVLLAPYVSRPDWPSGWL
                     TLTRTTEEGYDEVRTHVLRCAADVPGFWRGVYTHERVPAERFFSFARDAFPRLLFANSL
                     SLHHFKGAYDEVLPWLVRLLGALDDHFVQVLAECGGDQNQVMRRFKALGLDISPESPNT
                     KKNAKAWEQRNVSHEGTTYRCEWHGKRRWDRDRVHFSLPIPEHDDRVLVGIFVGHLAT"
     misc_feature    complement(13733..13735)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(14004..15125)
                     /locus_tag="LJA35_RS13070"
     CDS             complement(14004..15125)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005483102.1"
                     /locus_tag="LJA35_RS13070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF3696 domain-containing protein"
                     /protein_id="WP_212731095.1"
                     /transl_table=11
                     /translation="MISSLEIRGFKRFKAESFDLRPLTVLTGVNGGGKSTMIQSLLLTR
                     LAETARGAAGGAVRLNGPLGLALGEARDVLNWSADTREITVRLGGPSGESWVYVLGLPD
                     SEQALHLQALRLPVQAVPGIGRDVRDPAFTYLCAERLGPRDTLAVSAEEPDRIGVGVRG
                     EYTAQVLALRDTRAVTSRRAVRESLRSPEAAGPQLRLQAEAWASHIIRPLRITARVAAG
                     IMAGMIRFGEPGLTGEEIRPVNTGFGVSYALPIVVAGLLTEPGDLLIVENPEAHLHPAG
                     QSRMGRFLARVAGSGVQVVMETHSDHVLNGARLAVAQDRALRAEDMITHYFDHDRVVPV
                     VINDKGELSHWPSGFFDQIESDLGRLARARRGR"
     gene            complement(15122..16300)
                     /locus_tag="LJA35_RS13075"
     CDS             complement(15122..16300)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005483101.1"
                     /locus_tag="LJA35_RS13075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF262 domain-containing protein"
                     /protein_id="WP_233645774.1"
                     /transl_table=11
                     /translation="MVMEGAQTAPGTPEVVEDVFEGHATDIEVEDTGEDTTRIQRPWNP
                     DQIRVNTSQFSLRNILDQIDEGSIELAPDFQRLRVWRSDQKSLLVESLLLQIPLPAFYF
                     AEDTDGSFRVVDGLQRLSTLHAFVRGGSGAFGLGKLEHLHDLKDLRFADLPVPFQRRIN
                     NTQLIVNVIDPTTPRGVTYEIFKRINTGGTPLNGQEIRHCMSSPRSRDILHRMTHTDAF
                     ARATGGRLTDHIRMNDREMALRFAAFWLKGLVTYQERPVMETFLMDATELLDDPKQVPD
                     EQVAELEDAFERAMSHAYLVFGDHAFRKWPEGENWRRPINRAMFESWSLALADPDRSAD
                     DLRARRKAVVAAARKRMTTDVTYLNAITSSTADRGRVDYRFKAAVADAGAGR"
     gene            complement(16412..17035)
                     /locus_tag="LJA35_RS13080"
     CDS             complement(16412..17035)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056400.1"
                     /locus_tag="LJA35_RS13080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_233645775.1"
                     /transl_table=11
                     /translation="MAAENPKDVVRRGYDALSRRYDEAYQSDTKYASWIASLNARLVDG
                     SRVLDLGCGNGVPVVRDLVRAGHHVTGIDISEVQIRRAQELVPDADFITADATAVDFPD
                     ASFDAVVSLYALIHVPLEEQLPLLGRIASWLRPGGWFLCSTGQHEWTGVDENWLGSGVA
                     MWWSHADADTNRAWLTRSGLTVVQEEFVPEGDSGHALFWARRPL"
     gene            complement(17210..18155)
                     /locus_tag="LJA35_RS13085"
                     /pseudo=""
     CDS             complement(17210..18155)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006142996.1"
                     /locus_tag="LJA35_RS13085"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="NAD(P)-dependent alcohol dehydrogenase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRAVQFDRFGPPDVLRVDDVPVPRRGPRRRARRERGRRRDRLPGG
                     QDAPGDPRPFPARSGQRLRRPGRGRRRRRTRLGRRRRGVGSHAAPHLRRHRRPRRRARA
                     AARPRSGEPEPGRGRRPAGGGHHGDDGPDRQGATPARGKAPGPRRHRRRRQRRRATGQG
                     ARRARDGPRRRPQPRLGHPARCGRGRGLPHDPARGPRPLRRDRRRRRHRPGRLPGAAGP
                     QGPPGRSRLRRGPRRLLHARHRPASGRRSPARQDVQQQPVGRPDRRPHPGRRGGNDPSG
                     DRHGLPRARHRGGPPTARIRRSPRQVRHRHAARL"
     misc_feature    complement(18199..18213)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.02"
                     /tool="antismash"
     gene            18310..18909
                     /locus_tag="LJA35_RS13090"
     CDS             18310..18909
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007387606.1"
                     /locus_tag="LJA35_RS13090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_233645776.1"
                     /transl_table=11
                     /translation="MSRENPGPPKRADARRNYDRILEAAAAEVARRGADASLEEIARRA
                     GVGSATLHRHFPSRWGLLQAVFQERVAQLCDEARSLAREHPPATALATWLTSLAVFGAV
                     TRGAARALLRATGTTASSSPDSRCEQLLMDAGGDLLARAQHDGTVRDDVTVVELVSLAN
                     AVSLAAEHTPDAAQHATRLMGIAVEGLGVPGHGPRD"
     gene            complement(18917..20416)
                     /locus_tag="LJA35_RS13095"
     CDS             complement(18917..20416)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973911.1"
                     /locus_tag="LJA35_RS13095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="carboxylesterase family protein"
                     /protein_id="WP_233645777.1"
                     /transl_table=11
                     /translation="MNRRPDPVVTTVQGAVRGLRQGDTRTFLNIPYAAPPRGAGRFAPP
                     QPHEPWDGVRDATVPGPNAPQSARRLGDIDMTPYFGAGWSRGEDYLTVNVFAPAAGGDA
                     GDALPVMVFVHGGGFVAGSTRAALYDGSAFARDGVVLVTLNYRLGIAGFLDVPGAPANR
                     GLLDVVAALRWVRENISAFGGDPRNVTLFGQSAGATIVGGVLATPEAAGLFRRAIVQSG
                     SGLGAFTPEQAARVTRAAAGALGIEPHVDAFGGIPDERLVEAAAGLTGIDLRTATHRDP
                     LIGLSPFSLVLDTQPAVSVAAGRAADVDLLVGTNAEEGNLYLVPVGKYATSTAADVDEA
                     AARSHPDPARLVETYRAARPGASFAELRSAIMGDALFGAGSRALADAHAAHPRSATHAY
                     RFAWRSHALDGELGATHGVELPFVFDLADRPELHGPAALLGPDEAPADLAGRVHETWIR
                     FARTGDPGWDPYDTDRRATMCIDAEWTRVDDPRGRERRAWS"
ORIGIN
        1 cacccgccgc gccccgcccg ccaaggaaac cgcaatccgc atatgcccga gcctacgccc
       61 aaccttcacg gagcgaatac gactttgcac aaagaggtac gcaaccagcc agaacgcagg
      121 gggcgcacgg tgcagaacgc gccgtctccg cacaccgatg cctccggtca caggcatacc
      181 ggagtcggag cgaacgacct gcgggaacga ccggattccg gcgccgcgcg aagggcaccc
      241 cgggagcgac ggatgcgcgg gcaggtgtgc gtacggagga aaggggcgcg ggaggcgcac
      301 gacgggcgtg cgccatctca caccgcgggg ccggacaact ccccgggccg gtgcgccact
      361 tgcggaacta cctgacgggc aggtggtacg ccacccggta ccggtcggcc gggacgacca
      421 cgtcggccgt ctccaccgcg cgccccgagg cgtagaacgt gcgctggacg accagcacca
      481 cgtgtcccgg tacgccgccc agggcgagca gctcctcggc gaggccgggg cgggcgccga
      541 cctcctcggt gacgttgtcc acgacgacgt cgatggcggc catccgctcg acgacgccca
      601 tgccgccgag cggcccctcc tcggggagca tcaccggcgt gcgcccggtc aggtccagcg
      661 gctcccagga ggtggagagc atgacggcct ccccggcctc ccggaagacg taccgggtgc
      721 acatcacccg gtcgccgggc tcgatgccga gccgctcggc cacggcgccg ctcgcctcgg
      781 cctgctcgct gcgcgactcc caggtgccgc gcgcgtcggc gtcggcctgc tcctgccgga
      841 agggcgtggc gccaccggcc ggccggtacc cggagcgggc gacgcgtctc gggacgggcc
      901 gctcgcgcac ataggtgccg gagccggagc ggccctcgac gagcccctcg gccatcagca
      961 ccttgcgggc ctccagggcg acggtgtccg agacgccgta ctcctcgcgg atccgcgcct
     1021 gggacgggag gcgggtatgg ggcggcagca ggccgtcggc gatcttcttg cggagatcac
     1081 ccgcgacacg cagatacgcc ggctgctcac cgaatgtcac tggccgctcc catcaggttg
     1141 tacagacagc aacagcgtgg caaccgtagg ttcggccggg caagcaaagg ccagagaatc
     1201 actcgaagtg atgacttgtg ccgcccgagg gctttacgca ggcactttct ccccgctatg
     1261 gccgctgtca cacctccttg ccggggctct ctcctccgcc gtcaccgctc tcctcgtaat
     1321 ccggcggcgt ggaggcgagg ccgagggact cgcgggcggt gaccgtggtg tcgccgtcga
     1381 tgagcccgta gccctggtag aggtgctcgt agaacgcgtc cgcctcggag gccacctccg
     1441 ccgcggcgaa ctcctcgcgt gccgcctcca ggtcggcgac cagctccgtg acctgccgct
     1501 cgctcgcgga cggccaggag tgcgcgccca gcatcccgat ctcctcggtg agcgcgttct
     1561 ccacccggcc cgcccaggac tgctgcgcga tcgggtcgtc ctcgaagtac tcgttctccg
     1621 gcgtcgactc cagggccgcg tccaggacgc gggccgcctt caggtaggcg agctggtgtg
     1681 cgtcgagcgt cgtgccgtcg ttgcgcagcg aacccgtcag gctcgcccct tcgtccgtgc
     1741 tgccgaacag gcagctgacc tcccggtcgc ccgacagcca gctgcgcgcg gtcggcgtca
     1801 ggtagtagac gtcgacgtcg gcgggcaggg cccaggtgtc catgacgtac ccgtccacga
     1861 ggccgtagca ccgcgcgtcg gccgcctcgg tgaccgcgtg gtcgccgggg tacgagccgc
     1921 tgcccggcat gtcgaacacg gcgaacacct cgccgtcgtg cgcgccttcg cagggcacca
     1981 cgtcgacgtc gtacgtcacc ccctcgaggg agccgcccgg tgtggtgaag cactggccct
     2041 tctcgagggc gtaggcggtc ccctcgccgc gtgcggcgtc cttgaagccg tcccagaagt
     2101 cggcggcggc gcccgtggag agcgtcagca cccacagggc cagcccgacg gaggacagca
     2161 cacatccggc caacgcgaat cccttgcccc gttcgccgcg cttgcggatg ccggccagcg
     2221 cgatcagccc cagcacgagc ccgaccgccg gcacgaagca caggaccccg agcacgaacg
     2281 cggcgacggc gagcccgttc acgggggcct gccgggggta cggcccgagc gggtgacccc
     2341 actccggagc gtacgggccc tgagcgtacg ggccctgggg atacggccct tgcggacccg
     2401 gcggaggcgg tatcgacacg ggtgccctgc tcctgttcag agggtggtgc ggcggcgggt
     2461 gcggcctcgc gcatcgtaaa cgcggccgga aagggagggt ggtgcgcggg tgcggtcttg
     2521 caggatgcgg tcgcgcgggg cgcggtcgta ccgggtgccg tcactgcctc cacagccgtc
     2581 tgagcgcgac caccggcgcg cccacggcca gacttcggcg acgagagcaa gacggcctcc
     2641 tggtacggca catggagcgg tcgggtacgg gaaccaaggt cccagacgat ctcgtcatgg
     2701 acggaacaac gctgtgggaa actgtcgcgc cacagtcgtc tggtacgggg gatgtcgtgc
     2761 acgggttcca gccacacgga ccgtccggcg ggccgtcgcc gcaacaggcc gagctcgccc
     2821 aactggtgcg ccggatacag agcttgtcga agccgtcggt gctgggcgtg atgctcggcg
     2881 caccgctgac cgcgggcggt gcgcactacg gcgccacgga gggacccgcc gggttcgtcg
     2941 cggcgctggt cggcgcggtg ctgctgaccg cgggtgtgct gggctaccgg cgggtgctcg
     3001 tcctgcgccg caggctgcgc tccctcatgc cggcggccca gcggtccccc gtcgcccatc
     3061 tgccgagcgc ccgccgcgcg gcgacgctgg ccgcctacgt caacggtgtg ctggtgctgc
     3121 tcggcctcgg cggcgcgggc tggctgctct acatgggcgc gtcctggggg gcgtacgaca
     3181 actccttcgg tttcgcggcg ctggtgatgg gcgcgctgct ccccttcgcg ctgggcctcg
     3241 ccgccgcctc caccgtcccc gaactgctac gggtggtgcc cgccggggcc cggatggggc
     3301 aggcgctgta cggcgtgttc gtctgcgtcg cgtcgctgat gatcgcgaag ggtgacgggc
     3361 tgctcccccg gctggtcggc gcggtgatcg ccgtgctcgc cctgggcgcg atcgccctgc
     3421 tcgggcggtg cttcagggtc atgggcgggg cggcaccccg gcagggcagc ggatcgccgg
     3481 gggccggaca gcccggcccc ggtcagccgg gattcggtcc gcccggcccc ggtcagccgg
     3541 gtttcggtca gcccgccccc gcgcccggat tcggaccgcc gacgtccccg cccggcggcc
     3601 cccacgggcc cgccccgtac gggcctccgg cgcctcgcgc cgggcgcggc ggactcgtcc
     3661 tcgtcctggt cctcgtgctg gtcgccgtac tcggcggcgg cggtctgtac gccgtgaagg
     3721 aggccgggct gctggacggc gacgactcga cgaccaccga cgtcgccgag agcccgcagg
     3781 cacccgcgta cggcgtcggc ggcgagcgca gggcgcggtg ggcgacgggg gcgcccgcgc
     3841 cggagggcac cgccccggag tacctggtgg gcggcgacga ggacgtcgtc gtgcacgtca
     3901 ccgggaccct ggtgaccggc tacgacgtgg cgaccggcaa gaagctgtgg gacgtcgagg
     3961 accggtcggg cgatttccgg acctgcgccg tctccccgac cgccgtcggt cacgtcgtcg
     4021 ccgtcctgat gcgccgcggt gaccagggcc cctgcggctt cctcgtcgcc gtcgacgtgc
     4081 ggcgcggcaa gcagctgtgg tcgaagggga tcctcggcga gggatccggc gcgggcatgg
     4141 gcacggccac cgtgcgcgtg accgcgaact ccgtggtgag cggcacgcag accgcccccg
     4201 tcgtcctcga cgcccgttcc ggggacgtcc gctggaccgg cgccgaccag cccgacgagg
     4261 acggcgaggc ccgttccctg cgcggcctgg aggtcgccgg gaacagcctc gtcgcctcgt
     4321 acggggacgg cctcggcgga tcgacggccc tgcgccgttt cgacctgcgc tcgggcaggg
     4381 tcaccgcccg cccgtcgccg ccgaaggccc ccgagacacc gaccccgaag gacgtcctga
     4441 gcgtgctctc cgtcgagccc ctggtcgtgt cgctcgggga cgacaccaac gcggaccgct
     4501 tctacttctc ccgggtcggc gacgcctgga agccgctgcg caccgacgcg gtggaggggg
     4561 tgagcgcgcg ctcgggtccg caggagggca tggtgaccga cgggctgttc gtcaaggcgt
     4621 tcaccaccga cgaccggtcg ttggacgtcg gtttcgacac cgtcgtcgcc gctttcgacc
     4681 tcgaatccgg cgcgttgagg tggcagcacg cgctccaccg ggacgccggc caggtcgtgc
     4741 tgctgcccgg cacggtcggg ggcgcggtcc gggccgtcgc ctccgaccac gacaccggcg
     4801 accagctcta cgccttcccg ctcgaggacg gcggcccggt ccggggcggc cgtctgacgg
     4861 tggacgcctc gctgtccggc gcgccgtccg ggctcaacga cctgacgggg gcggtggtcc
     4921 agggggagcg gctgatcgta cggagccagg tggacgggac cctggtggcg ttcccgttcc
     4981 cgtccaaggc gtaggcaagg cgggcggggc ggaccggccg gtgcggttca gccgtcgaac
     5041 gcggtggccc gggtgagctt ctcccaggcc tcgacgtcct cgcggacctg gtcgaggtgg
     5101 ccgaggaccg cgctgacgcc gtcgtcgccc agcggcagcc gcagcggggt gtgctcggcc
     5161 gcgagggcgg cccggatgac cgccgccgcc ctggccgggt cgccgggctg gctgccgtcg
     5221 cccccggcga tcatcccgcg ggtctcgcct accttggcgt acacgccgct gtccgcgctg
     5281 atcccggcgt tgccggcctg gaagaggccg gtgcggaagg agcccggctc cacgatcagc
     5341 accttgacgc cgaagtcccg gacctcgtcc gcgagcccct ccgacatgcc ctccagcgcg
     5401 aacttcgtgc cgctgtacgc cgagaagccc gcgaaggaca tctgcccgcc catgctgctc
     5461 atctgcacga tcgcgcccga gctccgctcc cgcatggacg gcagcaccgc ccgcgtcagc
     5521 gcggccggcc cgaagacgtg cacgtcgaac agtgcccgca gttcgtcctc gccggtctcc
     5581 tccagggcgc cgacgtgcgt gcggcccgcg ttgttgacca gcacgtcgac cctgccgtac
     5641 cgccccacca cgtcccgtac cgcgtcctcg gcggcggccg tgtcggcgac gtccaggcgc
     5701 agcgcctcca tctggtcggg gtgcgcggcc acgaggtcgt cgagcgcctc gggacgccgt
     5761 gccgcgccga cgaccacgtc accgtcggcc agggccgcct cggcgagcgc ccgcccgaat
     5821 ccgctgctcg ctccggtgat cagccacacc ttgttcatgc cgactcctcg gtcgttgtcg
     5881 ttccggcacc gaccaccctg gtccacgagc cggttgccgg tccaagaccc acggtgatag
     5941 ccagtggtta tgacgacgga cgtacacgtg cgcgagctgc gctacttcgt gacggtggcc
     6001 gaggaactgc acttcacccg ggcggccgag cgtctgtacg tgtcacagcc cgcgttgagc
     6061 aagcaggtcc gggcgctgga gcggcagttg ggcgccgagc tgttccgccg cgacccccag
     6121 ggcgtggccc tcaccgaggc gggcacggcg ctgctgccgc atgcccggcg ggtgctggcc
     6181 gactgggccg ggggcgcggc ggcggtggag gccgcccggg cggcgcggcg cgccaccctg
     6241 gtcgtcggca tgagcaccag ccccgggcgc ggcggtctgc tgccggcgat ccgctcgcgc
     6301 ttcacggcgg cccacccgga ggcggtggtg cggctgcggc agatgggctg ggaggactcg
     6361 accgcgggcc tggccgacgg cacggccgac gtcgcgtacg tgtggctgcc gctgcccgac
     6421 gccggccgct acgcctggac ggtggtcgcc gaggaacccc gcctggtcgc cctccccgac
     6481 gaccaccccc tcgcctcccg cccggaggtc gacttcgccg acctcgtcgc cgagccgttc
     6541 ctcgccctgc cgccggaggc gggcgtcctg cgcgacttct ggctggcact ggacgaacgg
     6601 cgcgcactcg gtgccgggcc ggcgcgcgtc ggcgccgaga tctccggcac ggaggagacg
     6661 tacgaggcgc tggtcgccgg cctcggcatc tgcctggtgg ccacgggcaa cgccccgctg
     6721 atcaccctgg gcggcgtcac cacccgcccg gtccgcggcc tgacacccag ccgttacgcg
     6781 ctggcctggc gccgcgagga cgaggggcgg gccctggtcc gggactacgc gcaggcctgc
     6841 cgccgggcga cggccggggg ctgaacgggg ccctcagtcg ccgcggtcgc gcacgtgcgc
     6901 gcgcactcct tgcagaccga acagcacgag cagttccacc gcgccgccgt cggcgctgcc
     6961 cagccagtgc ggcagggacg tgtcgaactc ggccgcctca ccgggcgtca gcgtgaggtc
     7021 gcgctcgccg accagcaagc gcagccgacc gctgagcacg tacagccact cggagccctc
     7081 gtgggtctgc ggggtcggtt cgaggggtgc cggacggctc gggatgatca tcttgaaggc
     7141 ctgggtgccg cccggccgcc gggagagcgg gacgaagacc atcccgaagc gcctgaccgg
     7201 cttcaggtgg atgcgcgggt cgcccgtgcg cggggcgccg acgaggtcgt ccagggggac
     7261 gccgtagatc cgggcgagcg gcagcagcag ctccagggtc gccctgcgcc gtccgctctc
     7321 cagccgggac agggtgctct ccgacactcc ggtcgccgtc gagaggtggg cgagggtgat
     7381 gccgcgctcg cggcgcagcg cgcgcaggcg ggggcccacc gcgtccagta cgtcgtccac
     7441 ctcgtccgtt ccggcgtcca tcgggccacc ttgccacaac cgcaagtttc cgtgccggat
     7501 ccggcggccg ctgccaagac tggccgcgtc cgttgctccc ggccgaccgg ccgggcccga
     7561 ccgaaggagt tccgatgagc gccaccgacg cggtcacgtt ctgggacggc gtgtacgcgg
     7621 cccgcccggc gtccgacgcc ccgcggccga acgtccgtct cgtcgaggcg gtctccgacc
     7681 tgtctcccgg cgacgcgctg gacctggggt ccggcagcgg cggcgacgcg ctgtggctcg
     7741 cccggcgggg ctggcgggtc acggccgtgg acgtctccgg cgtggcggcc gaacggctcg
     7801 cggggcacgc ccgcgccctc ggcctcggcg accgggtgga cgccgtacgg ctcgatctgc
     7861 gcgcgtcgtt ccccgagggc cggttcgacc tggtctgcgc gcactacctc cacacgccgt
     7921 tcgacctgga ccgggcggcg gtcctgcgta cggccgcgca cgcgctgcgc ccgggcgggc
     7981 ggctgctggt cgtcgaccac ggctcgaccg cgccgtggtc gtgggaccag gaccccgacg
     8041 tccggtaccc ggccccgcgg gaggtggcgg cgggcctcgg cctcgacccg gcgacgtggc
     8101 gggtggaacg ggcggaggcc gcccgccgga ccgcgaccgg cccgggcggt cgtaccgccg
     8161 aggtcgtcga ccacgtcctg ctcgtccggc gcgccggctg agggcgcccg tcccgtccac
     8221 gaggagggca ccatgtccac cacccaccgc cgcgacacgc cgccgccccg caccgggaac
     8281 gacgaggccg cgaccctgcg cgggttcctc gactacctgc ggacctcgat cgccggcaag
     8341 gtcgagggtg ctccggagcc gggggtccgc acggccgcgg tgccgtccgg cacccatctg
     8401 ctcgggctgc tcacccacct gacccacgtc gaacgggccg tcttcctcgg ggcggaggtg
     8461 cggagctggc cggcgacgtt ccgtgccgcc ccccaggacg gcgtggccga ggtcgtcgct
     8521 cgctaccgcg aggccgtcga cgacgcgaac cgagtcctcg acacctgcac cgacctcggc
     8581 gccccactcc cccggccccg tccgggccgc cccgccccga gcgtccgctg ggccctcacc
     8641 cacatgatcg aggagaccgg tcggcacgcc ggtcactcgg acatcctccg cgagctgatc
     8701 gacggcacca cggggcggtg accggcgccg tcccgtggtg ccgtgcccgg ccttcagccc
     8761 gcgctcgcgg ccctgcgtga gcggcggttg cgccaccagg tgaccagcca gaggacgttg
     8821 acgccgccga ggaccaccag caccgtcacc gcgtcggcgt tgccggccag gccgtgttcc
     8881 ggtcccagac cgcgcacggc gcgggcgagg agggcgaggt cgacgggcag ggtgaccgcg
     8941 gccatgaacg tcaggcaggc cgccgtaccc accacgagga cgacgctgta gatccgcacg
     9001 gcccgccgct cgtgcgcggg cagccgggcg ctggggtcgt cccgcgccgc cccggcacga
     9061 ggaccacggc gcaccggccg cacggcgcgc cggaacctgt accgcgcgta cgccagaccg
     9121 tcgccgtaca ggtcccggca gccggtgagg tcctggagga cgaagtacag gtcggtgcgg
     9181 gtgaagacca tgcactggaa gggcagcggc agcagggcga ggagcagggc tgcggccagc
     9241 aggcggtggg cggtcgtccc ggtctccgtc acggcgagga ccaggacgag cgacgacgcc
     9301 acggacaggt tgagggcgat accggccagg taggccgtca gccggtggcg gcggggcgcg
     9361 agttcgatgc cgctgatgtc ggtctgcatg acgaggaact gcagccgggt gcccagccgc
     9421 atcttccccg gcacgcccgc ggcccgggcg gtgaccaggt gcgccagttc gtgggccagc
     9481 agcagcgccc agccggccgc cgccccgctc aggagcacca cgctgccgtg gcggctccac
     9541 agcaggtcgc ggtagccggg caccaggtcg gggcggcgca ccaggaccac gagggcggcc
     9601 gtgagcagcg ctccgacgag cagcgggagc accgggtgca gggcgaggcg gacgtggcgg
     9661 gggcgcagcc acggcagtga cgcccggggc ggttcgacgt ccgggaccgg acggtcgccg
     9721 atccgcgcca cgaaacccag cgcggtcagg tccccgacga agtccgcgat gtcgaactcc
     9781 tccccggtct ccgcacgcag cgtctcttcg gtgcgcgtca cgctccgccc ctcgcgcagg
     9841 agttccaccg cgcgcgcccc ggccgccggg agggcgacga aggtgcgggt ggccatgcgg
     9901 cccacgatcc actcgtcgcg gtcgggtcgt accgccaggt cgtgcaggac gacgcgggtc
     9961 gtcggcccga tccggggagg gtcgtcggcg gcggtgtccg tcacgacggg tcccggtcgc
    10021 cggagccggc acgcgccgcc ggtagcgggt caggtacggg gtccgatacg ggctcccata
    10081 cggggtcagg aacggggccc gttaccgggt cgggctccgt ccggcggcag gccgggcagt
    10141 cggggcgccg ctgtgcgcgt tgcaggaccg ggtcacccgg cagcatgagg ttgaggccga
    10201 accggcatcc ggggtcgacg ggcgggacgc cgcacagcag catcagggcg gcgtgcgcca
    10261 gcagcccgcc ggacaggccg gcggtcacgg cgttggccgg gttccacggc atgcggggcg
    10321 aggccacgtc ctcgtcctgg ccggggccga gccgcaggtc gcgccgttcg acctcggcgt
    10381 cgcgcaggca ctgccagcac gcgccccggc cgggcgtgaa gacaccgacg ctgaccagcg
    10441 gcccgcgata gcccgcttcg gcccacggcg tgcccgtcga caggcagatc tggttggccc
    10501 acctgcggat ctcggcggga cggtcggcgg cgagcagcag tgcgtcgtaa ccgggcgcgc
    10561 ggaccgggct gtcggggctg cgtcgaccgt tggtgccgct gcttcggctt ctgcttcggc
    10621 ttcggctgcc ggccccggtc agcagctctt cgaggtccgc cggaccgcgc acctcgcgcc
    10681 gctcgccggt gacctcggtg tccgggttca gcgcgcgcag ggcggtgagc gccgcgtcga
    10741 gcttcggctt gccgaggtcg ctctcgtgga agagggtctg ccggttgagg ttggacagtt
    10801 cgaccacgtc cggttcgacg cagtgcagcc gccccacgcc ggacgccacc aggtcccggg
    10861 cggcggccga gccggtgccg ccgaccccga ccagcaggac ccttgcccgg cgcagcagca
    10921 gttgcggctc ccaggcactg ctcctgggcc gcaggtccat ccagcgcagc agggtcatgc
    10981 tcctgctgta ccgctcgcgt tcccgctcgg acagttcggc gggcggctcg gcgccggcgt
    11041 cctcgacgta tccggcgtcg gtgaggtccg tcatcgcctg ggcgatgtcc ggggccggca
    11101 gccgcagttc cggatggcgt cgggacacct cggcgacgac gtccgtggcg ctccgcgtcc
    11161 cgtccatggc ctgcaccagg gtccagaccc agccgtcggc gtcccgtacc tcggctccga
    11221 tgccgtggac gacactgccg atccgcacgt ggccgtccac ggtccggtag gcgcggtgct
    11281 ccggcttgat ccggggcagc cgcatcgcgt gcaccgtcat tttcgcgcca acctcgccat
    11341 ccccaactac gcgggcaaca acggacattg acaacagtga ccgggtgagc gaacgctgac
    11401 aagagcacaa cgtgccccgc aggccacagc acgacgaccg caacggcacc acgacacaac
    11461 ggcaccacgg tcctcaccat ggtcaccacc ggaaggagac gacatggcga acaagatcga
    11521 gatccgtccg ctggacaaga aggagaccac cggcgacagc ggcggcaacg gcggcgcctg
    11581 accggacgcg cccgatgcac cgctacccca cggtcgcgga agtcaccgag gcggcgcgac
    11641 ggctggtctc ccggttcccc ggggcctgcc gcctgcgccg tatcggcacg tcccgggcgg
    11701 gccggccgct gctgatgctg tcggtgggac acgggccgcg ccacgtcctg gtggtggccc
    11761 ggccgcaccc ggacgaaccg gtgggcggcg cgacggcgct ggcgctggcg gagcgggtcg
    11821 cagccggcga ccggtgctcc ccggcgaccg accccgacac cgtcacctgg gacatcgtcc
    11881 tgtgcctcga cccggacggc gccgcgctca gcgagggcat cgaggcggcc acggccggcc
    11941 ccgaccccac cctggcccgc tactaccgcg ccgccttccg cccggtcgcg gcggaacagc
    12001 cggagtgggc gccgatcgtg gggcggcgac tgcccgagag ccgcgccctg ttcgcggtga
    12061 tcgacgaact ccgcccggtc ctccagtgct ccctgcacaa cgtcgacgcg ggcggcacct
    12121 gggtccagct gaccggcgac ctccccggcc tcgccgcccc ctacgcggcc tccgcctcgg
    12181 ccctgggcat cccggtccag cacggcacgt acgacgccct gtactgggag aacccggccc
    12241 ccggcatcca catcctgccg ccccccgaca gcaccgcccg actggcggcc gggtccgaga
    12301 acatcgccct gtccacctgg tgcgcacccc agcggtacgg cggcgtcacg gcgatcgtcg
    12361 aggtccccct gtgggccacc gccccggccg acgaccggac cccgcacccg ggccccgccc
    12421 gcgccctgcg cgacctctcc gcgctggtac gcgagggcgg ccgtcaggtg accgccgtct
    12481 tcgacaaggc tcgcgacttc ctgcccccgg ccgagcacag cccgccccga cgcgtactgg
    12541 agtggatggc cgacgacctg tacgacctgg tcgccgacgc ctggcagcct ctcgccgaac
    12601 aggcccgatc ggcatccgac tcccccgcac agacgacggc cggaatcagc gccctggagg
    12661 tcgtcgcccg ccgccagcca ctgcgcgcgg cgggcctcct gctacgcctc ctggactcga
    12721 ccgacgaccc ggcgtccgcc gccctccacc acgaactcga cggcctcttc accacttggt
    12781 gcacgcagtt cgaacagtcc ctgcacctgc gcccggtccc cgtgcacgcc caggtggaac
    12841 tccagaccca cacggtactg gcggcagcgg agtgcgcgct ggggcgctga ggcggtcctg
    12901 cgccctgttc ggagttcgtc gggtgcctgc ggcgcagcaa cctccggtga ttccattggg
    12961 ccactgccgt agacgcggac cacagctggg ccaccgtccg ccctcaggtc gccaggtgcc
    13021 ccacaaagat tccgaccaga acgcggtcgt cgtgctccgg gatcggcagg gagaagtgca
    13081 cccggtcgcg gtcccaccgt cgcttgccgt gccactcgca gcggtaggtg gtgccctcgt
    13141 gactgacgtt gcgctgttcc cacgccttcg cgttcttctt cgtgttcggg ctctcgggcg
    13201 agatgtccag gcccagggcc ttgaaccggc gcatgacctg gttctggtct cctccgcact
    13261 cggccaggac ctggacgaag tggtcgtcga gcgcgcccag cagccgcacc agccagggca
    13321 gtacctcgtc gtaggcaccc ttgaagtggt gcaggctcag ggagttggcg aacaggagcc
    13381 ggggaaacgc gtcccgggcg aaggagaaga agcgttccgc gggaacacgc tcgtgggtgt
    13441 agacgccgcg ccagaaaccg ggcacgtccg ccgcgcatcg caggacgtgc gtccgcacct
    13501 cgtcgtaccc ctcctccgtc gttcgcgtca gggtgagcca cccggacggc cagtccggcc
    13561 gcgagacgta gggcgccaga aggacggaca tggcacgccc gccggcggcc cgtgcgaggg
    13621 cgtgggcgac cccccaggag ggctcccgct caaggccgtc ggccgcccgg accggccggg
    13681 gcagatccgc ctcgacgggc tcgacgacgc ggcacttgtc cagcagcttc tgtaaccgga
    13741 tccggtcatc gtgcgacagc ccgctgcccg gcgagtagag ggcgtcgatc agcttggtcg
    13801 acggcaggca ctcagcgtcg tacgccgcgt cgacgaacgc ggtggtacgc ccgtcggcca
    13861 gtggctgaag cacctcggcc aacgctgcca gggcctcccc cagcaggccg gggtcggcca
    13921 gctcgcgcca gtcgaagcat tcctcgccga tcaccacacg gtagtcgtcg gcggcacctg
    13981 gcacatccac gatctcgcct gtctcacctg ccgcgtcggg cacgtgccag cctcccgagg
    14041 tcactctcga tctggtcgaa gaagccgctt ggccagtggc tgagctcccc cttgtcgttg
    14101 atgacgacgg gcaccactcg gtcgtggtcg aagtagtggg tgatcatgtc ctccgcccgc
    14161 agtgcccggt cctgtgccac ggcgagccgg gcgccgttga ggacgtggtc actgtgggtc
    14221 tccatcacga cctgcactcc gctgcccgcc acccgagcca ggaaacggcc catgcgggac
    14281 tgtcctgccg ggtgcagatg cgcctccgga ttctccacga tcagcaggtc acccggctcg
    14341 gtgagcaggc cggcgacgac gatcggcaga gcgtaggaga caccgaagcc cgtgttgacg
    14401 ggccgaatct cctcaccggt cagaccgggc tcaccgaacc tgatcatccc agccatgatg
    14461 cccgcggcca cccgagcggt gatccgcagc ggacggatga tgtgtgaggc ccacgcttcg
    14521 gcctggagcc tgagttgggg acccgcggcc tccggactgc gcagcgattc acggaccgcc
    14581 ctgcggctgg tcaccgcccg ggtgtcgcgc agcgcgagca cctgcgctgt gtactcgccc
    14641 cgaacgccga ccccgatccg gtccggttct tcggcggaca ccgcgagggt gtcgcggggg
    14701 ccgagccgct cggcgcacag gtaggtgaac gccgggtccc tgacatcccg cccgattccg
    14761 ggcacggcct gcaccggcag ccgcagcgct tgaagatgca gcgcctgttc cgaatcgggc
    14821 agccccagga cgtacaccca cgactcgccg gacgggccgc ccaggcgcac ggtgatctcc
    14881 cgagtgtcgg ccgaccagtt caagacgtcc ctggcctccc cgagggccag ccccagaggg
    14941 ccgttcagcc ggacggcgcc gccggccgcg ccgcgtgccg tctcggccag tcgcgtcagc
    15001 agcagcgact ggatcatcgt gctcttgccc ccgccgttga cgccggtcag gacggtcaga
    15061 gggcgcaggt cgaacgactc ggccttgaag cgcttgaagc cccggatctc cagggaggag
    15121 atcaccggcc ggcccccgcg tctgccacgg ccgccttgaa gcgatagtcg acccggcccc
    15181 ggtctgcggt ggaggaggtg atggcgttga ggtaggtgac gtccgtggtc atccgtttgc
    15241 gggcggcagc cacgacggcc ttgcggcgtg cgcgcaggtc atccgcgctg cggtcgggat
    15301 cggccagggc cagcgaccaa ctctcgaaca tggcacggtt gatcgggcgc cgccagttct
    15361 cgccttcggg ccacttgcgg aaggcgtgat cgccgaacac gagatacgcg tgggacatcg
    15421 cgcgttcgaa ggcgtcctcc aactccgcca cctgctcgtc cggcacctgc ttggggtcgt
    15481 ccagcagttc ggtggcgtcc atcaggaacg tttccatcac cggccgctcc tggtaggtca
    15541 ccagcccctt caaccagaac gcggcgaacc tcagcgccat ctcgcggtcg ttcatccgga
    15601 tgtggtcggt caggcggccc ccggtggccc tggcgaaggc gtccgtgtgg gtcatccggt
    15661 gcaggatgtc acggctgcgc ggactgctca tgcaatgcct gatctcctga ccgttgagcg
    15721 gcgtaccgcc ggtattgatc cgcttgaaga tctcgtacgt gactccacgg ggtgtggtcg
    15781 ggtcgatcac gttgacgatc agctgggtgt tgttgatccg gcgctggaaa ggcacgggga
    15841 gatccgcgaa gcgcagatcc ttgaggtcgt gcaggtgttc cagcttgccg agaccgaagg
    15901 caccggaccc gccccgcacg aaggcgtgca gcgtggacag gcgctgcaga ccgtccacga
    15961 cgcggaacga cccgtccgtg tcctccgcga agtagaaggc gggcagcggg atctgcagca
    16021 gcagggactc gacgagcagc gacttctgat cggaccgcca gacccgcaac cgctggaagt
    16081 ccggagcaag ttcgatggaa ccctcgtcga tctggtcaag gatgttgcgc agggagaact
    16141 ggctggtgtt cacccggatc tggtccgggt tccacggccg ctggatacga gtggtgtcct
    16201 ctccggtgtc ctccacctcg atgtccgtgg cgtgcccctc gaacacgtcc tccaccacct
    16261 ccggggtccc cggagccgtc tgcgcgcctt ccatcaccat gtgggccatc ctatggacca
    16321 aacccgagcc gagtggtggc gttgcgcggg atgctcctcg gcgttcacgt gacacagagg
    16381 cactcagaga ggggaacacg gtccccccgc atcacagcgg acgtcgtgcc cagaacagtg
    16441 catgcccgct gtccccctcg gggacgaact cctcttgcac aaccgtcagg cccgaccggg
    16501 tgagccaggc tcggttggtg tcggcatccg cgtggctcca ccacatggcg acgccactgc
    16561 ccagccagtt ctcgtccacg ccggtccact catgctgacc agtgctgcag agaaaccagc
    16621 caccgggccg cagccacgac gcgatccttc ccagcaacgg aagctgttcc tccagcggga
    16681 catggatcaa ggcgtagagg gacaccacag catcaaaaga agcgtccggg aagtccaccg
    16741 ccgtggcgtc ggccgtgatg aagtcggcgt cgggcacgag ttcctgagcc cgacggatct
    16801 gcacctcgct gatgtcgatg ccggtgacgt ggtgtcccgc cctcacaagg tcacgcacga
    16861 ccggtactcc gttgccacag cccaggtcca gcaccctgct gccgtccacg aggcgcgcgt
    16921 tcaggctcgc gatccacgac gcgtacttcg tatcggactg gtacgcctcg tcataacgcc
    16981 gcgaaagcgc gtcataccca cgtcgcacca cgtccttggg attctctgca gccacagccg
    17041 aggacgctag cgcccttgtt ctccgcccgg cgaacccttt tcgcccggta cccggcgcgg
    17101 gcagtcttcg ccccagtgca gtagagccct tgagcacagg tgacgctcgg acgagtcacc
    17161 ggccgaccgg gccgccgatc accgccgcac cgcgtcaccg catcggggcc taggcgagcc
    17221 gcatgtcgat gacgtacttg ccgcggactc cgccggattc gagccgtcgg tggaccgccg
    17281 cgatgtcgtg cacggggaag accgtgtcga tcaccggacg gatcgttccc tcctcgacgg
    17341 cccgggtgag gtcggcgatc cggtcggccg acgggttgtt gctgaacatc ttgacgcgcc
    17401 ggggagcgac ggccgctcgc aggacgatgc cgagcatgga ggagacgacg cggtccgcgt
    17461 cgaaggcgag agcgaccagg cggcccttgg gggccagccg cgcccggtag gcgcccaggt
    17521 cggtgccgac gacgtcgacg atcacgtcga agcggtcgag gtcctcgggc cgggtcgtgc
    17581 ggtagtccac ggcctcgtcc gcaccgagcc gggtgaccca gtcgaggttg cgggcgccgg
    17641 cgagggccgt cacgtgcgcg ccgagcgcct tgcccagttg cacggcgacg ctgccgacgc
    17701 cgccggtggc gccgcggacc aggagctttt ccccgggccg gagtcgcgcc ttgccgatca
    17761 gggccgtcat cgccgtggtg cccaccaccg gcagggcggc ggcctcgacc gggctcaggt
    17821 tctccggagc gcgggcgagc cgccgctcgg gcacggcgac gtggtcggcg atggcgccga
    17881 aggtgaggtg cggcatgaga ccccacaccg cgtctccgac gccccaggcg cgtacgccgt
    17941 cgccgacggc cgcgacccgg ccggcgaagt cgctgcccag accgcgcggg aaacgggcgc
    18001 gggtcacccg gcgcatcttg cccgcccgga aggcggtctc gccggcgtcc acgctcgcgg
    18061 cgtgcacgtc gacgaggacc tcgccggggc acggggacgt cgtcgacacg cagaacgtcg
    18121 ggtgggccaa atcggtcgaa ctgaacggcg cgcatgcctt cgtctcctgt gtcatggaca
    18181 gaaacggggt acccctccgc ttttttgaat atgggggcac cccccactta ttgtcaaacg
    18241 gccgagcccg acggcggtgc aagaatgggg tggcaccccg ctttaccggc gaggaaggag
    18301 accacaagcg tgagcaggga gaatccgggc ccgcccaagc gcgcggacgc acgccgcaac
    18361 tacgatcgga tcctcgaggc cgccgcggcc gaggtcgccc ggcgcggagc cgacgcctcc
    18421 ctggaggaga tcgcacggcg ggccggcgtc ggctccgcca cgctgcaccg ccacttcccg
    18481 tcccggtggg gcctgctcca ggccgtcttc caggagcgcg tggcgcagct ctgcgacgag
    18541 gcccggtccc tggcgcgcga gcacccgccc gcgaccgccc tggcgacatg gctgacgtcc
    18601 ttggcggtct tcggcgccgt gacgcgcggc gccgcccgtg ccctgctgcg ggcaacgggc
    18661 accaccgcct cgtcctcgcc ggactcgcgc tgcgagcaac tgctgatgga cgcgggcggc
    18721 gacctcctgg cccgcgccca gcacgacgga accgtccgcg acgacgtgac cgtcgtcgaa
    18781 ctggtctccc tcgccaacgc ggtgtccctc gcggccgaac acacccccga cgccgcgcag
    18841 cacgccaccc ggctcatggg gatcgccgtc gagggcctgg gtgtgcccgg acacggcccc
    18901 cgcgactgac ccgcgttcag ctccaggcac gccgttcccg gccgcggggg tcgtcgaccc
    18961 gcgtccactc ggcgtcgatg cacatggtgg cccggcggtc ggtgtcgtac gggtcccagc
    19021 cggggtcgcc ggtcctggcg aaccggatcc aagtctcgtg gacgcggccg gcgaggtccg
    19081 cgggggcctc gtcggggccg agcagggcgg ccgggccgtg gagttccggc cggtccgcga
    19141 ggtcgaacac gaagggcagt tcgaccccgt gggtggcgcc cagttctccg tccagggcgt
    19201 gggagcgcca ggcgaaccgg taggcgtggg tggcggagcg cgggtgggcg gcatgggcgt
    19261 cggccagagc gcggctgccc gcgccgaaca gggcgtcgcc catgatggcg gagcgcagtt
    19321 ccgcgaagga cgccccggga cgtgccgcgc ggtaggtctc gacgagccgc gcgggatcgg
    19381 ggtgcgagcg tgcggcggcc tcgtcgacgt cggcggcggt cgaggtggcg tacttgccca
    19441 ccgggaccag gtagaggttg ccctcctcgg cgttggtgcc gacgagcagg tcgacgtcgg
    19501 cggcgcgacc ggcggcgacg gagacggcgg gctgggtgtc caggaccagg ctgaaggggc
    19561 tgaggccgat cagcgggtcg cggtgggtcg cggtccgcag gtcgatgccc gtcagcccgg
    19621 cggccgcctc gacgagccgc tcgtccggga tgccgccgaa ggcgtccacg tggggctcga
    19681 tgcccagggc cccggccgcg gcgcgggtga cacgggcggc ctgctcgggc gtgaacgcgc
    19741 ccaggccgct gccgctctgc acgatcgccc ggcggaacag cccggcggcc tcgggggtgg
    19801 cgaggacgcc gccgacgatg gtcgccccgg ccgactggcc gaagagggtg acgttgcgcg
    19861 ggtcgccgcc gaaggcggag atgttctccc ggacccagcg cagtgcggcg acgacgtcga
    19921 gcagaccgcg gttggcgggc gccccgggga cgtcgaggaa cccggcgatc ccgagccggt
    19981 agttgagggt gaccaggacg acaccgtcac gggcgaacgc ggaaccgtcg tacagggcgg
    20041 cccgcgtcga cccggcgacg aaaccgccgc cgtggacgaa caccatgacc ggcagggcgt
    20101 cacctgcgtc acctccggcg gcgggcgcga agacgttgac ggtgaggtag tcctcgccgc
    20161 ggctccagcc ggcgccgaag tagggggtca tgtcgatgtc gccgagcctg cgcgcggact
    20221 gcggggcgtt gggccccggg acggtggcgt cccgtacgcc gtcccacggc tcgtgcggct
    20281 gcggcggggc gaacctgccc gcgccccggg gcggggcggc gtacgggatg ttcaggaagg
    20341 tgcgggtgtc gccctggcgc aggccgcgga cggcgccctg cacggtggtg acgacggggt
    20401 cggggcgacg gttcatggct cgtgtcctcc cgcggggctc aggcccgctc ggtgtacttg
    20461 gcgaagggcg cccagccctt gatggcgaac ttgcttcccg cgcgcacgac ttcggcggca
    20521 ccgtggccgc cgaggtgtgc ggggaagacg agggcgttgc tgtcgaccgc cgcgcccagg
    20581 agcttgtggc gggtggcgcg ggccgcggcg gggtcctcgc agaagcagct gttggcgtcg
    20641 ggttcgtgga tctggatcgg gctgtgcatc aggtcgccga cgaacagggc ccggtccgag
    20701 ccggattcca gccgcagcac cgacgagccc ggggtgtggc cgggggcgag gtcgaggcgc
    20761 aggtgggagt cgatttggtg actgtcctcc cacagcaggg tgagaccggc ctcgtgcacg
    20821 ggggcgacgc tgtcctcgaa gacgttctgg ttgccgcggc cgagcagggt cttgatctcg
    20881 ttggccgggt tccagtagtc gaagtccgcc ttggccatca agtaggtggc gttggggaag
    20941 gtcggtgccc aggtccgccc gtcgaggtac gtgttccagc cgacgtggtc gacgtgcagg
    21001 tgggtattga tcacgatgtc gacgtcctcg gggcgcaccc cggcgcgggc gagattgccc
    21061 aggaagtcgg tgtccaggcg gctccacacc ggtgcgtacg gccggtcctt gtggttgccg
    21121 acgccggtgt cgaccaggat ggtccggccc tcgctgcgca ggacccaggt ctggatcgcg
    21181 gtgttgacga tgcgggtctc ggcgtccagg aagtccggca ccagccagga acggtgcgcg
    21241 tcccacgcct gagccgggct gtccgggacg aacgcctcgg gcgtcaggtc gacgggaccg
    21301 tagtactccc ggacccgggt
//
