LOCUS       NZ_CP085300            21074 bp    DNA     linear   CON 18-JAN-2024
DEFINITION  Streptomyces sp. BSE6.1 chromosome, complete genome.
ACCESSION   NZ_CP085300
VERSION     NZ_CP085300.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. BSE6.1
  ORGANISM  Streptomyces sp. BSE6.1
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8024389)
  AUTHORS   Ramesh,C., Anwesh,M., Vinithkumar,N.V., Kirubagaran,R. and
            Dufosse,L.
  TITLE     Complete Genome Analysis of Undecylprodigiosin Pigment
            Biosynthesizing Marine Streptomyces Species Displaying Potential
            Bioactive Applications
  JOURNAL   Microorganisms 9 (11), 2249 (2021)
   PUBMED   34835376
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8024389)
  AUTHORS   Chatragadda,R. and Maile,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-OCT-2021) Andaman and Nicobar Centre for Ocean Science
            and Technology, National Institute of Ocean Technology, Dollygunj,
            Port Blair, Andaman and Nicobar Islands 744103, India
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 10-OCT-2021
            Assembly Method                   :: Unicycler v. 0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/18/2024 07:10:02
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,273
            CDSs (total)                      :: 7,198
            Genes (coding)                    :: 7,094
            CDSs (with protein)               :: 7,094
            Genes (RNA)                       :: 75
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 104
            CDSs (without protein)            :: 104
            Pseudo Genes (ambiguous residues) :: 0 of 104
            Pseudo Genes (frameshifted)       :: 47 of 104
            Pseudo Genes (incomplete)         :: 80 of 104
            Pseudo Genes (internal stop)      :: 9 of 104
            Pseudo Genes (multiple problems)  :: 30 of 104
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:03:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 277094
            Orig. end                         :: 298168
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP085300.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from National Institute of Ocean
            Technology.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21074
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="2"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21074
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21074
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11074](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11074)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    486..500
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
     gene            1329..2357
                     /locus_tag="LJA35_RS01220"
     CDS             1329..2357
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007459171.1"
                     /locus_tag="LJA35_RS01220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_165285541.1"
                     /transl_table=11
                     /translation="MFTSHDGLCGIGELAESAGVTVKTVRFYSDRGLLPEASRSAGGHR
                     RYGPEALDRLRLIRSLRALDLGVPEVRRILDERHADGAAGGGSGSGGALEAAVAGRLRE
                     VGSELRALRWREAALRLVQESPPGEQADRLRLIGAVSVPPSTAPLVRFWRGWLPARMPA
                     RSAGAFLDVAVPQPPDDPSPAQVLAFARLNALTLAPCPGTAQPQPEAHRAAGARGAAVL
                     YAALAEAYELAGAQLRRGREPHPGEALDGFVGAYTSAYGVRDTPEFRRRLAGQLAADPR
                     LDGYWELVSEVNTAPGGRPEPTPGTAHDWLLAALTAQTGAVPVQGTSPRQSKRRASPGL
                     GA"
     gene            complement(2300..2566)
                     /locus_tag="LJA35_RS01225"
     CDS             complement(2300..2566)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027204.1"
                     /locus_tag="LJA35_RS01225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_102927352.1"
                     /transl_table=11
                     /translation="MDEVEFMRGRVYGADHDNPGPRAGRVYAHLVGGPLDGLLLDVTDL
                     TEQERGRAVALATEIGRYGPGGRSAYAPRPGDARRFDWRGDVP"
     gene            complement(2729..3730)
                     /locus_tag="LJA35_RS01230"
     CDS             complement(2729..3730)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027205.1"
                     /locus_tag="LJA35_RS01230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphotransferase"
                     /protein_id="WP_233644755.1"
                     /sec_met_domain="APH (E-value: 1.9e-08, bitscore: 33.2,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSDAPEAVDRGLYQDTVTPWEEPAWRAEVLDWVRSGLTARGLRP
                     TGQWRVRLRPWSVLLRLSVREGDAVWFKANPPGSAFEGALTAALARWVPGHVLEPLAVD
                     TDRGWSLLPDGGPLFREVLARETVTPGAWEELVRQYAAVQHALTVRAPEIERLGVPAVP
                     VRALPGVLDGLDDSSLPHRDRVALRDLRPRVLDWCAELDALGVPDSLDHADLHEGQLFR
                     PAPGRFTFFDWGDAVVAHPFAGLVVPARRAVERHGPHVLPRLRDAYLEPWTDAGRTAAR
                     LRRAASLAWRLSALNRAAAYGRLFPTASGATGAATAAAGARCLLELLDEPPF"
     gene            complement(3869..6091)
                     /gene="katG"
                     /locus_tag="LJA35_RS01235"
     CDS             complement(3869..6091)
                     /EC_number="1.11.1.21"
                     /GO_function="GO:0004096 - catalase activity [Evidence
                     IEA]"
                     /GO_function="GO:0004601 - peroxidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="katG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978302.1"
                     /locus_tag="LJA35_RS01235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="catalase/peroxidase HPI"
                     /protein_id="WP_233644756.1"
                     /transl_table=11
                     /translation="MSENHDAIVTDAKAEETGGCPVPHGRAPHPTQGGGNRQWWPERLN
                     LKILAKNPAVANPLGEEFDYAAAFNSLDLPAVKRDIAEVLTTSQDWWPADFGNYGPLMV
                     RMAWHSAGTYRISDGRGGAGAGQQRFAPLNSWPDNGNLDKARRLLWPVKKKYGQNLSWA
                     DLLVLTGNVALETMGLETFGFAGGRADVWEAEEDVYWGPETTWLDDRRYTGDRELENPL
                     GAVQMGLIYVNPEGPNGNPDPIAAARDIRETFRRMAMNDEETVALIAGGHTFGKTHGAG
                     PADAVGDDPEAAPMEQMGLGWKSTHGTGTGGDAITSGLEVTWTSTPTQWGNGFFKNLFE
                     FEYELEQSPAGAHQWVAKDAPEIIPDAHDPAKKHRPRMLTTDLSLRLDPIYGPISRRFY
                     ENPEEFADAFARAWFKLTHRDMGPKSLYLGPEVPEETLLWQDPLPEPEGEAIDAEDIAT
                     LKTKLLESGLSVAQLVSTAWASASTFRGSDKRGGADGARIRLEPQRGWEVNDPDELAQV
                     LRVLEGVQREFNAGAGAKHVSLADLIVLGGSAAVEKAAKEAGFEVEVPFAAGRVDATEE
                     HTDAESFEALEPTADGFRNYLGKGNRLPAEFLLLDRANLLTLSAPEMTVLVGGLRVLGA
                     NHQQSQLGVFTRTPGSLTNDFFVNLLDLGITWKSTSEDRTTFEGRDAATGEVKWAGSRA
                     DLVFGSNAELRALAEVYASDDAKEKFVHDFVAAWVKVMNLDRFDLA"
     gene            complement(6116..6571)
                     /locus_tag="LJA35_RS01240"
     CDS             complement(6116..6571)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1266: hydrogen
                     peroxide sensitive repressor"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978301.1"
                     /locus_tag="LJA35_RS01240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Fur family transcriptional regulator"
                     /protein_id="WP_102932816.1"
                     /transl_table=11
                     /translation="MTASRHSRNPATADELRRAGLRVTAARVALLETVREGDHLDAEAL
                     TSGVRRRVGHVSLQAVYDALHALTAARLVRRIEPPGGPARFEGRVGDNHHHVLCRSCGT
                     LADVDCAVGDAPCLTASDDHGFVIDEAEVIYRGLCPGCSTPGSSPAP"
     gene            6766..7866
                     /locus_tag="LJA35_RS01245"
     CDS             6766..7866
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978300.1"
                     /locus_tag="LJA35_RS01245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF475 domain-containing protein"
                     /protein_id="WP_233644757.1"
                     /transl_table=11
                     /translation="MLVKTFRWAFVVTALGLAAGVLYDGWTALGIVAILSVLEISLSFD
                     NAVINAGILKKMNAFWQKIFLTVGIVIAVFGMRLVFPVVIVAISARLSPWNAVHLALTD
                     KDRYQELVTDAHPSIAAFGGMFLLMIFLDFVFEDREIKWLGWLERPLARLGSVDMLSVC
                     IALIVLLISATTFGANAHQHGGTHADKAETVLLAGVAGLITYMVVGGLSGFFEQRLEHE
                     EEREQEAEERAERTGRRGSPVELAGKAAFFMFLYLEVLDASFSFDGVIGAFAITNDIVL
                     MALGLGIGAMYVRSLTVYLVRQGTLDDYVYLEHGAHYAIGALSLILLVTIQYQINEIIT
                     GLVGVVLIGASFWSSVRRNRSLRTAS"
     misc_feature    7901..7914
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     gene            7963..8385
                     /locus_tag="LJA35_RS01250"
     CDS             7963..8385
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019330749.1"
                     /locus_tag="LJA35_RS01250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF350 domain-containing protein"
                     /protein_id="WP_061440648.1"
                     /transl_table=11
                     /translation="MTDIVNGLGRAAAYGGLGLVLLVLGIVLVDLLTPGKLGRQIWEQR
                     NRNAALVLSSALLGIGGIVFTSIWTTYEDFGKGLVSTAVFGLLGLVMMAVAFLVVDLIT
                     PGRLGATLVEPEPHPAVWVTASCNLAVSAVIAASIA"
     gene            complement(8398..9831)
                     /locus_tag="LJA35_RS01255"
     CDS             complement(8398..9831)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978299.1"
                     /locus_tag="LJA35_RS01255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="WGR domain-containing protein"
                     /protein_id="WP_102932818.1"
                     /transl_table=11
                     /translation="MSRTYLELSQDGGGAHKFYEVTVQGQVVSVRYGRIGAAGQTQTST
                     FPTAQKAEAAAAKKIGEKIRKGYEPAVQGQRAPRAVTRRQVASAPSTARAVAPVLWRFR
                     TGSAAFGIHIDEDKCWVGNQAGDVYTLAHGGEVLARYQLPDGVKCLVADDFWIYAGCDD
                     GRVYDLSSKLPFAAYDIAADVDIFWLDIHEGVLNVADRAGRLTVIDHEDEHQWSRGGRG
                     EHAWMVRADDRAVYHGHTRGVTAHAPDGGTELWHTPTQGAVLFGWQEDDAVYAGTARHT
                     VQRLSKATGVIEATYHCDSPVYSCATSPGGRFVFAGDSASSVYCFDRDGTRLWKLGTGG
                     GSALSMQYRDERLFLVTTDGSLVCVDASETAVAAAQQGSVPVARDVKLAATLPTYAPAT
                     AAAAVATVTAAPAGSVVVECVQENGRTRIHVVSEGYDHSWNVQFPRAIREPGARYVVDA
                     LHAASGGFYRVRGDIRRLR"
     gene            complement(10001..11074)
                     /locus_tag="LJA35_RS01260"
     CDS             complement(10001..11074)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978295.1"
                     /locus_tag="LJA35_RS01260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_102932819.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 2.3e-43, bitscore:
                     147.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEQPPARVAGYERRFNTLFAQYFDTLGTTLDTPSFSRFTPDCVE
                     LLRDLSLRGGKRMRVVLLHEAARLVTAEPVEGLDAAALSVELLQTHGLVHDDLIDDSAT
                     RRGGPTTYYAYREKFPGHPRAALALTVLAGDLALALSLRVLLEARLPTEVRQAMVEVQT
                     RAAADTFVGQIVDLERDFSTTPPDDEILHAVADHKSARYSVLAPLRLGLLAAGEQPDAH
                     EPGLSDYARLLGICGQMRDDYLDLFGDAEAMGKPTGTDIREGRHTYTVVRLLSAVSGAE
                     RDFVRRALGDPACTPQTIAEIRAIGEQAGVADRMRADMRRYAERARLVAESWRPRRRED
                     AVAFFEQLPRWSVERAA"
     gene            11226..13067
                     /locus_tag="LJA35_RS01265"
     CDS             11226..13067
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1296: tellurium
                     resistance protein, TerD"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006128202.1"
                     /locus_tag="LJA35_RS01265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TerD family protein"
                     /protein_id="WP_233644758.1"
                     /transl_table=11
                     /translation="MSLASAPSDLSDLRDYAFEWALVDVETSGLVPRRDRVLSVAVVTL
                     GPDGEQTGEFSTLLDPGCDPGPVHVHGLTAERLRGAPAFEQVAERIGALLEGRVLVAHN
                     AQFDYDFLAHEFARARLRLPVDRRLCTLALNRRVDPPTGDLKLGTLAAHYGVPQFKAHD
                     ALDDTRVLAGVLRASLRAAAGLDLPLPLVACPPRQDPRFAPKPPKTPCAFRNPGRPAPG
                     GPLVQGMKVAVTGETGTDRADLVLRGVAAGLNMMGSVSRHTSVLVTNEPSGGSAKARRA
                     RAEGVPVIDESAFLRLLGDVRPGTPHEGAATALSPGLPAVPTPRDPAAGEAAGPKPGAK
                     RSAKPRGPLTGRRVLVLGGTHPDAVAARTRVVELGGAAAINLSAGVTDVVVLDGGHGDR
                     RLARITALLLPVHDAAWLVAPVVTEAAGAGEGRAAAHVLPRGGVVDLPLPKGRGPADRW
                     TVTASWAQQTACEIDVVAFVLDEDEQVSFDEDFVFYGAPENPGGTVRLLSDGPTEQTVS
                     VDLATLPPSARKVVVAAAIDGSPAFGDVGALHIVSGPGAGAAALAQATLDAATTERTML
                     LAEIYRRGESWRLRAVGQGYDHDLGALARGYGVDVTD"
     gene            complement(13155..13277)
                     /gene="ykgO"
                     /locus_tag="LJA35_RS01270"
     CDS             complement(13155..13277)
                     /GO_component="GO:0005840 - ribosome [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="ykgO"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003046794.1"
                     /locus_tag="LJA35_RS01270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type B 50S ribosomal protein L36"
                     /protein_id="WP_003978293.1"
                     /transl_table=11
                     /translation="MKVRNSLRALKARPGAQVVRRRGVTYVINKKDPRFKARQG"
     gene            complement(13307..13471)
                     /gene="rpmG"
                     /locus_tag="LJA35_RS01275"
     CDS             complement(13307..13471)
                     /GO_component="GO:0000315 - organellar large ribosomal
                     subunit [Evidence IEA]"
                     /GO_component="GO:0022625 - cytosolic large ribosomal
                     subunit [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpmG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005063154.1"
                     /locus_tag="LJA35_RS01275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="50S ribosomal protein L33"
                     /protein_id="WP_019330754.1"
                     /transl_table=11
                     /translation="MARSTARPVVRLKSTAGTGVTYVTRKNRLNDPDRLVLRKYDPVAG
                     EHVPFREER"
     gene            complement(13577..14905)
                     /locus_tag="LJA35_RS01280"
     CDS             complement(13577..14905)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1247: acetylornithine deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027210.1"
                     /locus_tag="LJA35_RS01280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="M20/M25/M40 family metallo-hydrolase"
                     /protein_id="WP_102932654.1"
                     /transl_table=11
                     /translation="MSTTAPAIVPASEEAQREVVDLCAELIRFDTSNPTSDERACADWV
                     VAQLAEAGIASELVESAPGRANVVARIPGADPSRGALLVHGHLDVVPADAAEWRVPPFS
                     GEIRDGYLWGRGAIDMKDTVAVMLATARHFARTGTRPAREIVLAFLADEEAGGRFGAHW
                     LVEHRPELFAGVTEAIGEGGGFSYALDDTRRLYPIENAQRGMAWMELTAAGRAGHGSSP
                     NDENAVTDLAESLTRIGRHTFPVRLIEPVRALLAEAARLQGVDLDLDAEDLDAELAKLG
                     HVADFMQVVLRNSANPTMFTAGYQTNVIPGRATARVDGRFLPGHEQELIDTIDALLLPS
                     VSREWVNHDIAMETSFDGPLVDAMCAAVRAEDPDGHPVPYCNPGGTDAKAFTKLDIRCF
                     GFKGLKLPHDLDYGRLFHGVDERVPLEGLRFGVRVMTRLWQDC"
     gene            complement(14902..16290)
                     /locus_tag="LJA35_RS01285"
     CDS             complement(14902..16290)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978290.1"
                     /locus_tag="LJA35_RS01285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytosine permease"
                     /protein_id="WP_165285533.1"
                     /transl_table=11
                     /translation="MDKNTAAESAQAATRAVGSDDYALSRVPRDKRLGFWTMLLQWLAQ
                     SGSISQFTLGATIGVGMTFGDAFLAFTLGAVILEVVIFAIGLAGMREGLATPLLTRWAG
                     FGRNGSALVSLVISVSLVGWFGVQNTIFGDSVSALVGGPSWLWCTAAGVGITVLVIFGF
                     KYMAVFAKIVTPLFFAMVAWSVTDALSDHSFSELIHSPAPGETIPLAVAATAIAGGFMT
                     GAIVSPEMTRYNRKGSHVFLQSASSMILSEYIVGLTGVLLGHMVGSGQVSQIVLSTSGV
                     FGVLVVLMSTAKINDWNLYGSSLGVVNFFQVVFGKRVHRGAVTIVLGIAGTLLSAIGMM
                     THFTDFLSVLGVAIPPVGGIIVAEYWVVRRMRAPLDATRDAQTLPATSPTWVPMSLVIW
                     AVAFCVGKFYDGGIPALNSLLTAFVLYCVLGLAGWIRTYGTTALDDTTEPTPAASGTAT
                     VGAP"
     gene            complement(16299..17252)
                     /locus_tag="LJA35_RS01290"
     CDS             complement(16299..17252)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009071169.1"
                     /locus_tag="LJA35_RS01290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF1177 domain-containing protein"
                     /protein_id="WP_125627357.1"
                     /transl_table=11
                     /translation="MLKYVLDLVDLLDDPDVDGKRVAAHLDSVAGPEGSGAEVTTVTGE
                     RGSTDFVLVRIPGRAGRTSGGSARTLGVVGRLGGVGARPEAVGLVSDADGAVAALATAA
                     KLLDMRRRGDVLDGDVIVATHICPNAPTAPHDPVPFMDSPVDIATMNRHEVTGEMEAVL
                     SVDTTKGNRIINHKGLALSPTVKEGWVLKVSERLGELLAVVTGEPLVTYPVTTQDITPY
                     GNGVHHINSILQPATATAAPVVGLAITSAAAVPGCQTGASHETDIAAAARFAVETAKAY
                     GGGQLDFHDDQEFDALVSRYGSLTRLQTLGREPGGS"
     misc_feature    complement(17344..17364)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.17"
                     /tool="antismash"
     gene            17384..18226
                     /locus_tag="LJA35_RS01295"
     CDS             17384..18226
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978288.1"
                     /locus_tag="LJA35_RS01295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_165285532.1"
                     /transl_table=11
                     /translation="MPGRPVEPLDRRTPAGALQTVDRALLVLLAFERTRPDWGVTEIAA
                     EFGWDTSVAQRLLSTLAGRGFLVSDPATRRYRIGPAALRLGRLWERSGSLELLAEPVLQ
                     ELRTATGDTVLFCLPDSFHMRCVAAVEGEEGPLRYYPLVGELYPAHAGATSKSFYAFLA
                     DDQRHRLFRGRPMARFTERTVTDPDQLEREFRTVRAQGYAWTVGEYDAGIGTVAMPVFL
                     GSEPYGSLSLGAAKERFPEGPEDRLEVLRRAVRLLEQRLTHPPQHHRRPRAPRTPPTA"
     gene            18306..19031
                     /gene="pepE"
                     /locus_tag="LJA35_RS01300"
     CDS             18306..19031
                     /EC_number="3.4.13.21"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene="pepE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018567759.1"
                     /locus_tag="LJA35_RS01300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="dipeptidase PepE"
                     /protein_id="WP_102932651.1"
                     /transl_table=11
                     /translation="MNLLLLSNSTQHGRGYLEHALGTVTGFLPTGARLAFVPYALADHD
                     AYTARVRGALSGAGIEVRGVHEGGDPLARLGEADAVFVGGGNSFRLLSALYRTGLREAL
                     IEAVAGGLPYMGASAGTNMAAPSLRTTNDMPIVEPPSFETLGLVPFQINPHYLDPDPAS
                     THKGETREERLREFLEENDVPVLGLREGSWLRVEGERAVLGGERDARLFRRGAEPRELA
                     VGSDLSELLSVRGEFDTRP"
     gene            19113..20336
                     /locus_tag="LJA35_RS01305"
     CDS             19113..20336
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978278.1"
                     /locus_tag="LJA35_RS01305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_102932650.1"
                     /sec_met_domain="p450 (E-value: 1.2e-28, bitscore: 98.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTAQQVPDILSPEFAANPYPAYRTMRDSAPLIRHEATQSWIVSR
                     YEDVERVFKDRAGQFTTENYDWQLEPVHGRTILQLSGREHAVRRALVAPAFRGADLQER
                     FLPVIERNSRELIDAFRHTGRADLVADYATRFPVNVIADMLGLDKADHDRFHGWYTSVI
                     AFLGNLSGDREVAAAGARTRVEFAEYMIPVIRERREKPGDDLLSTLCAAEVDGVRMSDE
                     DIKAFCSLLLAAGGETTDKAIAGIFANLLAHPEQLAAVREDRSLIPRAFAETLRYTPPV
                     HMIMRQTATDVTLSGGTIPAGATVTCLIGAANRDENRYRDPDRFDIMRDDLTTTTAFSA
                     AADHLAFALGRHFCVGALLAKAEVETGVGQLLDALPDLRTEDGFEVVERGVFTRGPQSL
                     PVRFTPAA"
ORIGIN
        1 cgcagccacg ccgggggcgc gtccagccag tcggcggcga tcaggccacc gccggagaag
       61 aaccacagcg cgatccggtc cccgtccacc cgcggatcgg cccgcgccag ttccacggcg
      121 gcggccacgt ccgcggcggc ccgctcgtag tcgccgaggt cgtgcaggcg gtggtcgagg
      181 aggacgccca cggctccgtc cccggccacg caccgtgcgt atcccgtcag gcccggccag
      241 tccctggggg tcggccgggc gtcggcgggg accgggccgc cgtgcacgaa caccaccgcg
      301 gggcgcggct ccccggcgtc gggcaggtag aggtcgacgt ttccgtgccg ttccctcggg
      361 acgtcgggca cgtccatcag gaacggccgc aggtgccccg gcccctcggc gtcgtcgacc
      421 ggctccagcc ggtgtccctc gcccgccgcg gcccgcaaca gcacgtccgt cagctcggcg
      481 gggcaggaca gcatcggcca gtggccggtg gggagttcga agaaggtcac ccgggggtcg
      541 gtcagggggc gcagcgcggg gtcgccgagg cgcaccagca tctgcatcaa ctcgatgctc
      601 gtgccgttgc ccgtgcacag cacgccggtg gtgggcaccg gggcgaccgc gccggtcagc
      661 cgcagcggct ggagcagggt gcccaggggc tggggcgcgg cgagggcggt gagccggtcc
      721 agtgcggcgt cggggactcc cgcggtgctg ccccagcgcg gccactcgtc gagcgccggg
      781 ggcggcaaca ggcccggggt ctcgtccgcc cctgcggttc cggcagttcc gggagttcgg
      841 gcgagacggt cgcgcaggga ctggtcgggc acggcggcca gggccgggac gccgtccctc
      901 ggcaggcccg agtccaggta gacgatccgc tcgatgtgct cggcgcgccg gtcggcggca
      961 ccgaccgccg ggtggatgcc gtagtcgtgg ccgaccagga cgatccgccg gcccccggcc
     1021 ccgcccgcgg cgccgaccac ggagtcgacc accgcgagca cgtccgcgat gtgggtctcc
     1081 aggtccacgg caccgtcgcc ggccgcgcgc ggtccgtcga ggccggtgag ggcgaccgtg
     1141 tgcacctcgg agcccgccgc ggtcaggcgc gcgacggtgt cctgccagat gtgggtgccg
     1201 gtgaacatgc ccgacaccag gatgaacgcg gtcatggtct gctctctcct ccgtccgtgg
     1261 cgcggcccgg cccgatcacc ggcccgccgt cgccggtacg gtaggaactc cccctgaggg
     1321 aggttcaagt gttcacgtcc catgacggtc tgtgcggcat cggcgagctg gccgagagcg
     1381 cgggtgtcac cgtcaagacg gtccgcttct actcggaccg aggtctgctg ccggaggcgt
     1441 cccgcagcgc cggagggcac cggcgctacg gtcccgaggc cctagaccga ctgcggctga
     1501 tccgctcctt gcgcgccctg gacctgggcg ttcccgaggt gcggcggatt ctcgacgagc
     1561 ggcacgcgga cggtgcggcg ggcggcggga gcgggtcggg cggggcactg gaggccgcgg
     1621 tggcgggccg gctgcgcgag gtcggctcgg agctgagggc gttgcgctgg cgggaggccg
     1681 cactgcggct ggtgcaggag tcgccgcccg gtgagcaggc cgaccggctg cggttgatcg
     1741 gcgccgtgtc cgtcccgccc agcacggcgc cgctggtgcg gttctggcgc gggtggctgc
     1801 cggcacggat gccggcccgg tcggccgggg ccttcctgga cgtggcggtc ccgcagccgc
     1861 ccgacgaccc ctctccggcc caggttctgg ccttcgcccg cctcaacgcc ctcaccctcg
     1921 ccccgtgtcc gggcaccgcc cagccccagc ccgaggccca ccgtgccgcc ggggcgcggg
     1981 gggccgccgt gctgtacgcg gcgctcgcgg aggcgtacga gctggccggg gcgcagctgc
     2041 gccggggccg ggagcctcat ccgggcgagg cgctggacgg cttcgtgggc gcgtacacga
     2101 gcgcgtacgg ggtgcgggac accccggagt tccggcgccg gctggccggg cagctcgccg
     2161 ccgatccgcg tctggacggc tactgggagc tggtgtccga ggtgaacacc gcgccgggcg
     2221 ggcggccgga gccgaccccg gggacggcgc acgactggct gctggcggcg ctgaccgcgc
     2281 agacgggggc ggtgccggtt cagggcacgt cgccccgcca gtcgaagcgg cgggcgtcgc
     2341 ccggcctcgg ggcgtaggcg gagcggccgc ccgggccgta gcggcctatc tccgtcgcca
     2401 gtgccacggc gcggccgcgc tcctgttccg tgaggtccgt gacgtccagg agcaggccgt
     2461 ccaggggacc gcccaccaga tgcgcgtaca cgcgtccggc gcgcggcccg gggttgtcgt
     2521 ggtcggcgcc gtagaccctg ccgcgcatga actccacctc atccatgcgt gaagcctcgc
     2581 atccggcact gacaacggcc cgcgcgacta gggggtgtcg ttcggatcag gccgactccg
     2641 ggcaacggtg cgttgctgcc aacccgtgcg tgccagaccc cgcgcccccg gcaagatcca
     2701 aacgacaccc cctggggccg ggaccgggtc agaagggcgg ctcgtccagt agttccagca
     2761 gacagcgtgc ccccgccgcg gccgtcgcgg caccggtggc accggacgcg gtggggaaga
     2821 gccggccgta ggcggcggcg cggttcaggg cgctgagccg ccaggcgagg ctcgccgccc
     2881 gccgcagccg cgccgccgtt cggccggcgt cggtccacgg ttcgaggtag gcgtcgcgca
     2941 ggcgcggcag cacgtgcgga ccgtggcgct cgacggcccg gcgggcgggg acgacgaggc
     3001 ccgcgaaggg gtgggccacg acggcgtcgc cccagtcgaa gaaggtgaac ctgccgggcg
     3061 cgggacggaa caactgcccc tcgtgcaggt cggcgtggtc gagggagtcg gggacgccca
     3121 gggcgtcgag ttccgcgcac cagtccagca cgcgggggcg caggtcccgc agcgcgaccc
     3181 ggtcccggtg cggcagcgag ctgtcgtcga gcccgtcgag gacgccgggc agcgcgcgca
     3241 cggggacggc ggggacaccc aggcgttcga tctctggcgc ccgcacggtc agggcgtgtt
     3301 gcacggccgc gtactggcgc acgagttctt cccacgcgcc gggggtgacc gtctcccgtg
     3361 cgagaacctc gcggaacagc ggtcccccgt cgggcagcag cgaccagccc cggtcggtgt
     3421 ccaccgccag cggctccagg acgtgcccgg ggacccagcg ggccagtgcc gcggtcagcg
     3481 cgccctcgaa ggcgctgccc ggagggttcg ccttgaacca gaccgcgtcg ccctcccgga
     3541 cggacagccg cagcaggacg gaccacggcc gcagccgtac ccgccactgt cccgtcggcc
     3601 gcagcccgcg ggcggtgagc ccggaccgga cccagtccag gacctcggcg cgccaggccg
     3661 gttcctccca cggggtgacg gtgtcctggt acagcccccg gtccacggcc tccggtgcgt
     3721 cactgagcat cgggccatcc cagcacggcg cgttgtgcgt gaccaccgct ttacccctcg
     3781 caagggccgc cggaccgccg gaccgccggt gccgctggtg tcggcaccgg cccgtccggc
     3841 ggccgtggga ctgcgcggac ggggtggatc aggccaggtc gaagcggtcg aggttcatga
     3901 ccttgaccca ggcggcgacg aagtcgtgca cgaacttctc cttggcgtcg tcgctcgcgt
     3961 agacctcggc gagcgcccgc agttcggcgt ttgagccgaa gaccaggtcg gcacggctgc
     4021 cggcccactt gacctcgccg gtggcggcgt cgcggccctc gaacgtggtc cggtcctcgg
     4081 acgtcgactt ccacgtgatg cccaggtcga gcaggttgac gaagaagtcg ttggtcagcg
     4141 agccgggcgt ccgggtgaac acgccgagct gggactgctg gtggttggcg cccaggacgc
     4201 gcaggccacc gaccaggacg gtcatctcgg gcgcgctcag ggtgagcagg ttggcccggt
     4261 cgaggaggag gaactcggcc ggcagccggt tgcccttgcc gaggtagttg cggaagccgt
     4321 ccgcggtcgg ctcgagcgcc tcgaaggact cggcgtcggt gtgctcctcc gtggcgtcca
     4381 cgcggcccgc ggcgaagggg acctccacct cgaatccggc ttccttggcg gccttctcga
     4441 cggccgccga gccaccgagc acgatcaggt cggccaggga gacgtgcttg gcgcccgcgc
     4501 cggcgttgaa ctcccgctgg acgccttcga ggacgcgcag gacctgggcc agttcgtcgg
     4561 ggtcgttgac ctcccagccg cgctgcggct cgaggcggat gcgggcgccg tcggccccgc
     4621 cccgcttgtc gctgccgcgg aaggtggacg cggaggccca ggcggtggac accagctgcg
     4681 ccacggacag gccggactcc agcagcttgg tcttgagggt ggcgatgtcc tcggcgtcga
     4741 tggcctcgcc ctcgggctcg ggcagcgggt cctgccagag gagggtctcc tcgggcacct
     4801 ccgggccgag gtacagggac ttggggccca tgtcgcggtg ggtcagcttg aaccaggcgc
     4861 gggcgaaggc gtccgcgaat tcctccgggt tctcgtagaa ccggcgggag atcggcccgt
     4921 agatcgggtc gaggcgcagc gacaggtcgg tggtgagcat ccggggacgg tgcttcttgg
     4981 ccggatcgtg ggcgtcgggg atgatctccg gggcgtcctt ggccacccac tggtgggcgc
     5041 cggccgggct ctgctccagc tcgtactcga actcgaagag gttcttgaag aagccgttgc
     5101 cccactgggt cggcgtgctg gtccaggtga cctcgagccc ggaggtgatg gcgtcgccgc
     5161 cggtgcccgt gccgtgggtg gacttccagc ccaggcccat ctgctccatg ggggcggcct
     5221 cggggtcgtc gccgacggcg tcggcggggc cggcgccgtg ggtcttgccg aaggtgtggc
     5281 cgccggcgat cagcgcgacg gtctcctcgt cgttcatcgc catgcggcgg aaggtctcac
     5341 ggatgtcgcg ggcggcggcg atcgggtccg ggttgccgtt cgggccctcc gggttgacgt
     5401 agatcaggcc catctggacg gcgccgagcg ggttctccag ctcgcggtcg ccggtgtagc
     5461 gccggtcgtc gagccaggtg gtctcggggc cccagtagac gtcctcctcg gcctcccaga
     5521 cgtcggcgcg gccgccggcg aagccgaagg tctccaagcc catcgtctcc agcgcgacgt
     5581 tgccggtgag gacgagcagg tcggcccagg agaggttctg gccgtacttc ttcttgaccg
     5641 gccacagcag gcggcgggcc ttgtcgaggt tgccgttgtc cggccagctg ttgagcgggg
     5701 cgaagcgctg ctggccggcg cccgcgccac cgcggccgtc gctgatgcgg taggtgcccg
     5761 cgctgtgcca ggccatccgg accatcagcg ggccgtagtt gccgaagtcg gcgggccacc
     5821 agtcctgcga cgtggtcagc acctcggcga tgtcccgttt cacggccggc aggtcgaggg
     5881 agttgaaggc ggccgcgtag tcgaactcct cacccagcgg gttggcgacg gcggggttct
     5941 tggcgaggat cttcaggttg agccgctccg gccaccactg acggtttccg ccgccctgcg
     6001 tggggtgcgg ggcgcgtccg tgggggaccg ggcagccgcc cgtctcctcg gccttcgcgt
     6061 cggtcacgat ggcgtcgtgg ttctcggaca tgggaatcct tccgaacggg gcggatcacg
     6121 gtgctgggga actgccgggg gtggagcagc cggggcacag gccccggtag atgacctcgg
     6181 cctcgtctat cacgaagccg tggtcgtcgg aggccgtcag acacggcgcg tcgcccacgg
     6241 cgcagtcgac gtccgcgagg gtgccgcagg accggcacag gacgtggtgg tggttgtcac
     6301 cgacccgtcc ctcgaaccgc gccgggccgc cgggtggttc gatacggcgc acgagccgtg
     6361 ccgcggtgag ggcgtgcagg gcgtcgtaca cggcctggag ggagacgtgc cccacgcgtc
     6421 ggcgcacccc cgaggtgagg gcctcggcgt cgaggtggtc gccctcccgg acggtctcga
     6481 gcagcgcgac gcgggcggcg gtcacccgca gtcccgcccg gcgcagctcg tcggcggtgg
     6541 ccggattccg ggagtgccgg gatgccgtca tgggggcgaa cctactccct ggcacacgaa
     6601 cgactcaagg aaacgagggg ctccactctg gatggccgcc gctgtcgggt gtcgtccgga
     6661 acgcctgtcc gggtgccgcc ggacggacgt ggtaggaaac gtgcgtggcg ggcactggca
     6721 ggggatgccg ccccgtatca gtgcgacgac aggaatgagt tgccggtgct tgtgaagacg
     6781 ttccgctggg ccttcgtggt caccgccctc ggcctggccg ccggagtgct ctacgacggc
     6841 tggaccgccc tcggcatcgt ggcgattctc tccgttctgg agatctccct gtccttcgac
     6901 aacgcggtga tcaacgccgg gatcctgaag aagatgaacg ccttctggca gaagatcttc
     6961 ctcaccgtcg gcatcgtgat cgcggtcttc gggatgcggc tggtcttccc cgtggtgatc
     7021 gtggcgatca gcgcccggct gagtccgtgg aacgcggtgc acctggcgct caccgacaag
     7081 gaccgctatc aggaactggt gaccgacgcc catccgtcga tcgccgcctt cggcgggatg
     7141 ttccttctga tgatcttcct ggacttcgtc ttcgaggacc gggagatcaa gtggctgggg
     7201 tggctggagc gtccgctggc ccggctcggc agcgtcgaca tgctgtcggt ctgcatcgcc
     7261 ctgatcgtgc tgctgatctc ggcgaccacc ttcggcgcca acgcccacca gcacggcggc
     7321 acgcacgccg acaaggccga gaccgtcctg ctcgcgggcg tcgccggcct catcacctac
     7381 atggtcgtcg gcggcctctc cggcttcttc gagcaacggc tcgagcacga ggaggagcgc
     7441 gaacaggagg cggaggagag ggcggaacgg acggggcggc gcgggtcccc cgtcgagctg
     7501 gcgggaaagg cggccttctt catgttcctc tacctggagg tcctggacgc gtccttctcc
     7561 ttcgacggcg tgatcggcgc cttcgccatc accaacgaca tcgtgctgat ggccctcggt
     7621 ctcggcatcg gcgccatgta cgtgcggtcc ctgaccgtct atctggtccg ccagggcacc
     7681 ctcgacgact acgtctacct ggagcacggc gcccactacg ccatcggcgc gctgtcgctg
     7741 atcctgctgg tcaccatcca gtaccagatc aacgagatca tcaccggcct cgtcggcgtc
     7801 gtcctgatcg gtgcgtcgtt ctggtcgtcc gtgcggcgca accgctcgct gcggaccgcc
     7861 tcttgagcga cacggcaggt gcgctacatt ttgcagcgcc ttgaccacga tcattcgcga
     7921 tccgacgcgc gcgatccctc acgctacgga gccggcaacg ccatgaccga catcgtcaac
     7981 ggactcggcc gggccgccgc ctacggcggc ctggggctgg tcctcctggt cctcggcatc
     8041 gtcctcgtgg acctgctgac gcccggaaag ctcggccggc agatctggga gcagcgcaac
     8101 cgcaacgccg ccctggtgct cagctccgcg ctgctcggca tcggcggcat cgtcttcacc
     8161 tccatatgga cgacgtacga ggacttcggc aagggcctgg tgtccacggc cgtgttcggg
     8221 ctgctggggc tcgtgatgat ggccgtggcc ttcctggtgg tcgacctgat caccccgggg
     8281 cggctgggcg cgacgctggt cgagccggag ccgcacccgg cggtgtgggt gacggcgtcg
     8341 tgcaacctgg cggtctccgc cgtcatcgcc gcctccatcg cctgacgccg cgccccgtca
     8401 ccggaggcgc ctgatgtccc cgcgcacccg gtagaagccg cccgacgcgg cgtgcagggc
     8461 gtcgaccacg taccgcgcgc cgggttccct gatcgccctc gggaactgga cgttccacga
     8521 gtggtcgtat ccctccgaca ccacgtggat gcgggtacgg ccgttctcct ggacgcactc
     8581 gaccaccacc gagcccgcgg gcgccgcggt cacggtcgcc acggcggcgg ccgcggtggc
     8641 cggcgcgtac gtcggcaggg tggcggcgag cttgacgtcg cgggcgacgg gaaccgagcc
     8701 ctgctgcgcg gccgcgaccg ccgtctcgct cgcgtccacg cacaccaggg agccgtccgt
     8761 ggtgacgagg aagagccgct cgtcgcggta ctgcatggac agggcggagc cgccgccggt
     8821 gccgagcttc cacaggcggg tgccgtcccg gtcgaagcag tacaccgagg acgcggagtc
     8881 gccggcgaag acgaaccggc cgccgggtga ggtggcgcag gagtagaccg ggctgtcgca
     8941 gtggtaggtc gcctcgatga cgccggtcgc cttggacagc cgctggacgg tgtggcgcgc
     9001 cgtgcccgcg tacaccgcgt cgtcctcctg ccagccgaag aggacggccc cctgggtggg
     9061 ggtgtgccac aactcggtgc cgccgtcggg tgcgtgggcc gtcacgccgc gggtgtgtcc
     9121 gtggtagacg gcgcggtcgt cggcgcgcac catccaggcg tgctcgccgc gccctccgcg
     9181 cgaccactgg tgctcgtcct cgtggtcgat gacggtgagg cggccggcgc ggtccgcgac
     9241 gttcagcacg ccctcgtgga tgtcgagcca gaagatgtcc acgtcggccg cgatgtcgta
     9301 ggcggcgaag ggcagtttgg acgacaggtc gtagacccgg ccgtcgtcgc agccggcgta
     9361 gatccagaag tcgtcggcga ccaggcactt gacgccgtcc ggcagttggt agcgggcgag
     9421 gacctcgccg ccgtgggcga gggtgtagac gtcgcccgcc tggttgccca cccagcactt
     9481 gtcctcgtcg atgtggatgc cgaacgcggc ggagccggtg cggaaccgcc acaggacggg
     9541 ggccaccgcg cgggccgtgg agggtgcgga ggccacctgc cggcgggtga cggcgcgggg
     9601 cgcgcgctgt ccctgcacgg cgggctcgta gcccttgcgg atcttctcgc ctatcttctt
     9661 ggccgcggcg gcctcggcct tctgcgcggt ggggaaggtg gacgtctggg tctgcccggc
     9721 ggcgccgatg cggccgtagc gcaccgacac gacctgtccc tggacggtga cttcgtagaa
     9781 cttgtgcgcg cccccgccgt cctgcgacag ctccaggtac gtcctcgaca tggcagacct
     9841 ctccccggtc ggtcccgcgg cgtgttccgc gggttccact gacagaaccg tagaaggtgc
     9901 cactgacaat cggccgtggt gagcggcccg gacggcccgc ccggctgccg gccggcgcgc
     9961 gggagaccgc ggcgctccgg ccggcccggg tgcgagcgga tcaggcggcc cgttcgacgc
    10021 tccaccgcgg cagttgctcg aagaaggcga ccgcgtcctc gcgccggcgc ggacgccagc
    10081 tctccgccac caggcgggcc cgctcggcgt accgacgcat gtcggcgcgc atccggtcgg
    10141 cgacgcctgc ctgctcgccg atcgcgcgga tctcggcgat ggtttgcggt gtgcaggcgg
    10201 gatcgccgag ggcccggcgc acgaagtccc gctcggcgcc gctgacggcg gacaggagac
    10261 ggaccacggt gtaggtgtgc cggccctcgc ggatgtcggt gccggtcggc ttccccatcg
    10321 cctccgcgtc gccgaacagg tccaggtagt cgtcgcgcat ctgtccgcag atgccgagca
    10381 ggcgcgcgta gtcgctcaac ccgggttcgt gggcgtccgg ttgctcgccc gcggccagga
    10441 gtcccagacg caggggcgcc aggaccgagt accgggccga cttgtggtcg gcgacggcgt
    10501 gcaggatctc gtcgtccggg ggtgtggtgc tgaagtcgcg ttccaggtcg acgatctggc
    10561 cgacgaaggt gtcggccgcg gcccgggtct ggacctcgac catggcctgg cgcacctcgg
    10621 tgggaagcct ggcctccagc agcacacgca gggagagggc cagggcgagg tcgcccgcga
    10681 gcaccgtgag ggcgagcgcg gcgcgtggat gcccggggaa cttctcccgg taggcgtagt
    10741 acgtggtggg gccgcccctg cgggtggcgc tgtcatcgat gaggtcgtcg tgcaccaggc
    10801 cgtgggtctg gaggagttcg acgctcagcg cggcggcgtc cagcccttcg accggctcgg
    10861 cggtcaccag gcgcgcggcc tcgtgcagca ggacgacccg catccgcttg ccgccgcgca
    10921 gtgacaggtc gcgcagcaac tcgacgcagt ccggggtgaa acggctgaag gacggggtgt
    10981 ccagggtcgt acccagggtg tcgaagtact gcgcgaagag cgtgttgaac cggcgctcgt
    11041 acccggctac gcgggccggc ggctgctcgg tcatgacgaa gtcctcctgt gggtggggcg
    11101 gatggcgcgc tcagcagtgt gtcagggcgg gccgggggcg ggcgacgcgg gcggagaaga
    11161 ccgcataacg ggaggaatgg acgttggagt tgaaggagat gtggagatgc ctccatcctt
    11221 ccttcatgtc tctcgcgtct gccccttccg atctgtccga cctgcgcgac tacgccttcg
    11281 aatgggcgct ggtcgacgtg gagacctccg gcctcgtacc gcgccgcgac cgggtgctgt
    11341 ccgtggccgt ggtgaccctg ggcccggacg gcgagcagac cggtgagttc tccaccctgc
    11401 tggatccggg ctgcgatccg gggccggtgc acgtgcacgg cctgacggcg gagcggctgc
    11461 gcggggcgcc ggccttcgag caggtggccg agcggatcgg ggcgctgctg gagggacggg
    11521 tgctggtcgc ccacaacgcc cagttcgact acgacttcct cgcgcacgag ttcgcacggg
    11581 cccggctgcg gctgcccgtg gacaggcggc tgtgcaccct ggccctgaac cggcgcgtcg
    11641 acccgccgac cggcgacctg aagctcggca cgctcgccgc gcactacggc gtgccccagt
    11701 tcaaggcgca cgacgcgctg gacgacacgc gggtgctggc gggggtgctg cgcgcctcgc
    11761 tgcgggcggc agcggggctc gacctgccgc tgcccctggt ggcctgcccg ccgcgacagg
    11821 acccgcggtt cgcgccgaag ccgccgaaga cgccgtgcgc cttccgcaac ccgggtcggc
    11881 cggccccggg cgggcccctg gtacagggca tgaaggtcgc cgtcaccggg gagaccggga
    11941 ccgaccgcgc ggacctggtg ctgcggggcg tcgcggcggg cctcaacatg atgggctcgg
    12001 tcagcaggca caccagtgtc ctggtcacca acgagccctc cgggggctcg gccaaggcgc
    12061 gccgggcacg tgccgagggc gtgccggtga tcgacgagtc ggccttcctg cggctgctcg
    12121 gcgacgtccg cccgggcacc ccgcacgagg gggcggcgac cgcgctctcc cccgggctcc
    12181 cggccgtgcc gacgccacgc gaccccgcgg cgggcgaggc cgccggcccg aagccaggcg
    12241 cgaagcgctc cgcgaagccg cgcgggccac tgaccgggcg ccgggtcctc gtgctcggcg
    12301 gcacccaccc cgacgcggtg gccgcccgca cccgcgtcgt cgaactcggc ggggccgcgg
    12361 ccatcaacct ctccgccggt gtcaccgacg tggtcgtcct cgacggcggc cacggcgacc
    12421 gccggctcgc caggatcacc gcgctgctcc tgcccgtcca tgacgccgcg tggctggtcg
    12481 caccggtggt cacggaggcg gccggggcgg gagaggggcg cgcggccgcc catgtgctgc
    12541 cgcgcggtgg cgtcgtcgac cttccgctgc cgaagggccg gggaccggcg gaccgctgga
    12601 ccgtcaccgc ctcctgggcg cagcagacgg cgtgcgagat cgacgtggtg gcgttcgtgc
    12661 tggacgagga cgagcaggtc tccttcgacg aggacttcgt cttctacggc gccccggaga
    12721 acccgggcgg cacggtgcgg ctgctgagcg acggaccgac ggagcagacc gtcagcgtgg
    12781 acctcgccac gctgccgccc tcggcccgca aggtcgtcgt cgcggcggcg atcgacggct
    12841 cccccgcctt cggcgacgtg ggcgccctgc acatcgtctc gggccccggc gccggcgcgg
    12901 ccgccctcgc ccaggccacg ctggacgccg ccaccaccga gcgcacgatg ctcctggcgg
    12961 agatctaccg gcgcggggag agctggcggc tgcgcgccgt cgggcagggc tacgaccacg
    13021 acctcggcgc cctcgcccgg gggtacggcg tcgacgtgac cgactgaccc cggccgcgta
    13081 gcccgaacgg gacacgcctc ggcccggccc ccctgtccgt ctggagcggg ggccgggccg
    13141 tcgagcgcgg ctgctcagcc ctggcgggcc ttgaagcgcg ggtccttctt gttgatcacg
    13201 taggtcacgc cgcggcggcg caccacctgg gcgccgggcc tggccttgag ggcgcgcagg
    13261 gagttgcgga ccttcacgac tgcctcctcc tgtttctcgg caccgttcag cgttcctcgc
    13321 ggaacggcac gtgctccccc gccaccgggt cgtacttgcg caggacgagc cggtcggggt
    13381 cgttgaggcg gttcttgcgg gtgacgtagg tgacgccggt gcccgccgtc gacttcagcc
    13441 tgacgaccgg gcgtgcggtg ctgcgtgcca tggtgctcct tccgaccgcg gcgcgggctg
    13501 ccgttctgtc ccgcgcatgt cagtcacgcc gcacaacgcc ggcggccgtc ggggcattcc
    13561 cgtcggccgt ggcgcgtcag cagtcctgcc acagccgggt catcacccgc accccgaacc
    13621 gcaggccctc cagcggcacc cgctcgtcga caccgtggaa gagccgcccg tagtcgaggt
    13681 cgtggggcag cttgagcccc ttgaagccga agcagcggat gtcgagcttg gtgaaggcct
    13741 tggcgtcggt accgcccgga ttgcagtacg gcaccgggtg gccgtcgggg tcttcggcgc
    13801 gtacggcggc gcacatggcg tcgacgagag gtccgtcgaa ggaggtctcc atcgcgatgt
    13861 cgtggttgac ccactcccgg gagaccgagg gcaggagcag ggcgtcgatc gtgtcgatca
    13921 gttcctgctc gtgccccggc aggaagcggc cgtcgacacg ggcggtggcc cggcccggga
    13981 tgacattggt ctggtagccg gccgtgaaca tggtcgggtt ggcggagttg cgcagcacga
    14041 cctgcatgaa gtcggccacg tggcccagct tggccagttc cgcgtccagg tcctctgcgt
    14101 cgaggtcgag gtcgaccccc tggaggcggg ccgcctcggc gagcagggca cgcaccggct
    14161 cgatcagccg gacggggaag gtgtgccggc cgatgcgggt gagggactcg gcgaggtcgg
    14221 tgacggcgtt ctcgtcgttc ggggaggagc cgtggccggc ccgcccggcg gccgtcagct
    14281 ccatccacgc catgccgcgc tgggcgttct cgatcgggta gaggcgccgg gtgtcgtcca
    14341 gggcgtagct gaagccgccg ccctcgccga tcgcctcggt gacacccgcg aacagctccg
    14401 gccggtgctc caccagccag tgggcaccga acctgccgcc ggcctcctcg tcggcgagga
    14461 aggcgaggac gatctcgcgg gccggccggg tgccggtgcg ggcgaagtgg cgggcggtgg
    14521 ccagcatgac ggccaccgtg tccttcatgt cgatggcgcc gcgtccccac aggtagccgt
    14581 cccggatctc gccggagaac ggcggcaccc gccactcggc ggcgtccgcc ggtacgacgt
    14641 ccaggtggcc gtggaccagc agggcgccgc gcgaggggtc ggcgcccggg atgcgggcga
    14701 cgacgttggc gcggcccggg gcgctctcca ccagctcgga ggcgataccc gcctcggcga
    14761 gctgcgccac gacccagtcg gcacaggccc gctcgtcgct ggtggggttg gaggtgtcga
    14821 agcggatcag ctccgcgcac aggtcgacga cctcccgctg cgcctcctcg gaggccggga
    14881 cgatggcggg tgcggtggtg ctcacggtgc tcctacggtg gccgtgccgg aggcggccgg
    14941 ggtgggttcg gtggtgtcgt ccagggccgt ggtgccgtac gtcctgatcc agccggcgag
    15001 gccgaggacg cagtagagga cgaaggcggt cagcagggag ttcagggcgg ggatgccgcc
    15061 gtcgtagaac ttgccgacgc agaaggcgac cgcccagatg accagggaca tcggcaccca
    15121 ggtcggcgag gtggcgggca gggtctgcgc gtcgcgggtg gcgtccaggg gcgcccgcat
    15181 gcggcgcacc acccagtact cggcgacgat gatgccgccc accggcggga tggccacgcc
    15241 cagcacggac aggaagtcgg tgaagtgcgt catcatgccg atcgcggaga gcagggtgcc
    15301 cgcgatgccg aggacgatgg tgaccgcgcc gcggtgcacg cgcttgccga agacgacctg
    15361 gaagaagttg acgacgccga gcgaggagcc gtacaggttc cagtcgttga tcttcgcggt
    15421 ggacatcagg acgacgagca cgccgaagac gccggaggtg gagagcacga tctgggagac
    15481 ctggccgctg ccgaccatgt ggccgagcag gacgccggtc aggccgacga tgtactcgga
    15541 gaggatcatc gacgaggcgc tctgcaggaa gacgtggctg cccttgcggt tgtagcgggt
    15601 catctccggg gagacgatcg cgccggtcat gaagccgccc gcgatggcgg tcgcggcgac
    15661 ggcgagcggg atggtctcgc cgggcgccgg ggagtggatc agctcggaga aggagtggtc
    15721 gctgagcgcg tcggtgaccg accaggcgac catggcgaag aacagcggtg tgacgatctt
    15781 cgcgaagacg gccatgtact tgaagccgaa gatgaccagc accgtgatgc cgacaccggc
    15841 ggccgtgcac cacagccagg aggggccgcc gacgagcgcg gacacgctgt cgccgaagat
    15901 cgtgttctgt acgccgaacc agccgacgag gctgaccgag atgaccaggc tgaccagcgc
    15961 ggagccgttg cggccgaagc ccgcccagcg ggtgagcagc ggggtcgcca gtccttcgcg
    16021 catgcccgcg aggccgatcg cgaagatcac gacttccagg atcaccgcgc cgagggtgaa
    16081 ggcgaggaag gcgtcgccga aggtcatgcc gacgccgatg gtggcgccca gggtgaactg
    16141 cgagatggag ccggactggg cgagccactg cagcagcatc gtccagaagc cgagccgctt
    16201 gtcgcgcggg acgcgggaga gggcgtagtc gtcgctgccg acggctcgcg tggccgcttg
    16261 cgccgattcc gcggcggtgt tcttgtccat gggcatgatc acgacccccc gggttcgcgg
    16321 ccgagggtct gcagccgggt cagcgagccg tatcgggaca cgagggcgtc gaactcctga
    16381 tcgtcgtgga agtcgagctg tccgccgccg taggccttgg cggtctcgac ggcgaaccgg
    16441 gcggcggccg cgatgtcggt ctcgtggctg gcgcccgtct ggcagccggg caccgccgcc
    16501 gccgaggtga tcgcgagacc gaccaccgga gcggccgtcg ccgtggccgg ctgcaggatc
    16561 gaattgatgt ggtgtacacc gttaccgtac ggggtgatgt cctgggtggt caccgggtac
    16621 gtgaccaagg gctcaccggt gaccacggcc agcagctcgc cgagccgctc gctcaccttg
    16681 agcacccagc cctccttcac ggtgggcgac agggcgaggc ccttgtggtt gatgatccgg
    16741 ttgcccttgg tggtgtcgac ggagagcacg gcctccatct cgccggtgac ctcgtgccgg
    16801 ttcatggtcg cgatgtcgac cggcgagtcc atgaagggca ccgggtcgtg cggtgcggtc
    16861 ggggcgttcg ggcagatgtg cgtggccacg atcacgtcgc cgtcgagcac gtcgccccgg
    16921 cgccgcatgt ccaggagctt ggcggcggtg gcgagcgccg cgaccgcgcc gtccgcgtcg
    16981 gagaccaggc cgacggcctc cgggcgcgcc ccgacgccgc cgagccgccc caccacgccg
    17041 agcgtccgcg cggagccacc gctggtacgg cccgcccggc ccggtatccg cacgagcacg
    17101 aagtccgtcg agccgcgctc gccggtgacg gtggtgacct cggcgccgga gccctccgga
    17161 cccgccacgg agtcgaggtg ggcggcgacg cgcttgccgt cgacgtcggg atcgtcgagc
    17221 agatccacga ggtccaggac gtacttcaac atgggcagtt ctcctgatcc gcaccggggg
    17281 cggtgctcac agcaggttcg ggatcgagta gcgttgtccg caactgtttc ccgttatctg
    17341 caatacgagt ctgaatggcg agatgtgagg gagaggagcc gtcatgcccg gtcgccccgt
    17401 tgagcccctg gaccgcagga caccggccgg ggcgctgcag accgtcgacc gcgccctgct
    17461 ggtgctgctg gcgttcgaac gcacccgccc ggactggggg gtcaccgaga tcgccgccga
    17521 gttcggctgg gacacctcgg tcgcccagcg gctgctctcc accctcgcgg gccgcggctt
    17581 cctggtctcc gacccggcca cccggcgtta ccggatcggc ccggccgccc tgcgcctggg
    17641 ccgcctctgg gagcgttcgg gctccctgga actgctcgcg gaaccggtgc tccaggagtt
    17701 gcggacggcg accggcgaca cagtgctctt ctgcctgccc gacagcttcc acatgcgctg
    17761 tgtcgcggcc gtcgagggcg aggaggggcc cctgcgctac tacccgctgg tcggcgagct
    17821 gtacccggcg cacgcgggcg ccaccagcaa gtccttctat gccttcctgg ccgacgacca
    17881 gcgccaccgg ctcttccgcg ggcgcccgat ggcccgcttc accgagcgca cggtcaccga
    17941 cccggaccag ctggagcgcg agttccgcac cgtccgagca cagggctacg cgtggacggt
    18001 cggcgagtac gacgccggca tcggcacggt cgccatgccg gtgttcctcg gctcggagcc
    18061 ctacggcagc ctcagtctcg gcgccgccaa ggagcgcttc cccgaagggc ccgaggaccg
    18121 gctggaggtg ctgcgccggg ccgtccggct gctggagcag cggctgacgc atccgcccca
    18181 gcaccaccga cgcccgcgtg caccccgcac accccccacc gcctgaccga ccgatccacc
    18241 cgatccaccc gatccacccg ttccgaccga tccacccgat ccgctcgtct gcgaggaccg
    18301 accccgtgaa tcttctgctc ctgtccaact ccacccagca cggccgcggt tacctggaac
    18361 acgccctcgg caccgtgacc ggtttcctgc ccaccggggc ccggctcgcc ttcgtgccgt
    18421 acgcgctcgc cgaccacgac gcctacaccg cccgggtgcg gggcgcgctg tccggcgccg
    18481 ggatcgaggt gcggggcgtg cacgagggtg gtgatccgct cgcgcggctc ggcgaggcgg
    18541 acgcggtgtt cgtcggcggc ggcaactcct tccggctgct gtccgcgctg taccgcacgg
    18601 ggctgcggga ggcgttgatc gaggccgtgg ccggcgggct gccgtacatg ggggccagcg
    18661 ccgggaccaa catggcggcg ccctcgctgc gcaccaccaa cgacatgccg atcgtcgagc
    18721 cgccgtcctt cgagacgctc gggctggttc cgttccagat caatccgcac tacctagacc
    18781 cggaccccgc ctccacgcac aagggcgaga cccgcgagga gcggctccgg gagttcctgg
    18841 aggagaacga cgtgcccgtg ctgggcctgc gggaggggtc ctggctgcgg gtcgagggcg
    18901 agcgggccgt gctcggcggc gagcgcgacg cccggctgtt ccggcggggg gccgagccgc
    18961 gcgagctggc ggtgggctcg gacctgtccg aactcctctc ggttcggggc gagttcgaca
    19021 cccgcccttg acccgtccgc cgcgcggtct gtcgaaggcg tcgcctcgtc aatagcctgg
    19081 tgggacaagg ccgttgtcga ccgaggagtc tcatgtccac cgcgcagcag gtccccgaca
    19141 tcctctcccc cgagttcgcg gcgaacccgt atccggccta ccggacgatg cgggacagcg
    19201 ctcccctcat ccggcacgag gccacgcaga gctggatcgt ctcgcgctac gaggacgtgg
    19261 aacgggtctt caaggaccgt gcggggcagt tcaccacgga gaactacgac tggcagctcg
    19321 agcccgtgca cggcaggacg atcctgcagc tgagcggccg ggagcacgcg gtccggcgcg
    19381 cgctggtcgc cccggccttc cgcggggccg acctccagga gcgttttctg ccggtcatcg
    19441 agcgcaactc ccgggagctg atcgacgcgt tccggcacac aggacgtgcc gacctggtcg
    19501 ccgactacgc cacccggttc cccgtcaacg tcatcgcgga catgctgggt ctggacaagg
    19561 ccgaccacga ccggttccac ggctggtaca cgtcggtcat cgcgttcctg ggcaacctct
    19621 cgggggaccg ggaggtcgcg gccgccggtg cgcgcacccg cgtggaattc gccgagtaca
    19681 tgatccccgt catccgggag cgtcgcgaga agccgggcga cgacctgctg tccacgctgt
    19741 gcgccgccga ggtggacggg gtgcggatga gcgacgagga catcaaggcg ttctgcagcc
    19801 tgctgctcgc ggcaggcggc gagaccaccg acaaggcgat cgccggcatc ttcgccaacc
    19861 tgctggccca cccggagcag ttggcggccg tgcgcgagga ccggagcctg atcccgcgtg
    19921 ccttcgccga gacgctgcgc tacaccccgc cggtccacat gatcatgcgt cagacggcga
    19981 cggacgtcac gctcagcggc gggacgatac ccgccggcgc caccgtcacc tgtctgatag
    20041 gcgcggccaa ccgggacgag aaccgctacc gcgacccgga ccgcttcgac atcatgcgcg
    20101 acgacctcac caccacgacc gccttctcgg ccgccgccga ccatctcgcc ttcgcgctgg
    20161 gccggcactt ctgcgtcggg gcgctgctgg cgaaggccga ggtggagacc ggggtcgggc
    20221 aactcctcga cgccctgccc gacctgcgca cggaggacgg gttcgaggtc gtggagcggg
    20281 gcgtgttcac gcggggcccg cagtcgctgc cggtgcggtt cacccccgcg gcctgacggg
    20341 ccgtacgcgt caggccacga cgggcgtgaa gacggcgggc agcgccgtca gaccgcgcat
    20401 ccagatggag ggacgccagg tcaactcccc cggctcgacg gcgagtacga gatcgggaag
    20461 gcgttccagc agggtctcga ccgcggtgcg ggcgatgacg tcggcgagca gcggcgccgg
    20521 gtaggggcag cggtgttcgc cgttgctgaa ggagaggtgc gcggagttct cggcgccgac
    20581 atgggcctcg ggccacagct gcggatcggt gttggccgcg gcgaggccga ggacgaggca
    20641 gtcgccggcc cggatctgcc ggccgcccag ctgggtgtcg cccacggccc agcggccgat
    20701 gaagttctgc gtgggggtgt ccagccacag cacctcgttg agggcctccc ccacactgag
    20761 gcggccgccg gagacgttga gcgcgaagcg ctcgtcggtg agcagcagac ggagcgtgtt
    20821 gccgatccag ttggcggtgg gctgctgggc ggcggcgatg acggagatca ggtcctggac
    20881 gatctcctcg tcggtcagtc ccgccgggtg ggtcagcatc cgggaggtga cgtcgggtcc
    20941 ggggcgttcg cgtttgtggc ggaccagccg gtggatgcgc tcgcccacgc gcgtgtacgc
    21001 ggcgaccggg tcgtcgccct cggccgcgtc gagggagatc cgcaggtcct cgacgagttg
    21061 ctgggtctcg gcgc
//
