LOCUS       NZ_CP089148            26296 bp    DNA     circular CON 12-FEB-2024
DEFINITION  Bacillus subtilis strain NIB353 chromosome, complete genome.
ACCESSION   NZ_CP089148
VERSION     NZ_CP089148.1
KEYWORDS    RefSeq.
SOURCE      Bacillus subtilis
  ORGANISM  Bacillus subtilis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 4247447)
  AUTHORS   Yoon,J.-A. and Kim,M.-D.
  TITLE     Complete genome sequence of Bacillus subtilis NIB353 isolated from
            nuruk
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4247447)
  AUTHORS   Yoon,J.-A. and Kim,M.-D.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-DEC-2021) Division of Food Biotechnology and
            Biosystems Engineering, Kangwon National University,
            Kangwondaehackgil-1, Chuncheon, Gangwon-do 24341, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: NOV-2021
            Assembly Method                   :: Unicycler v. v0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 147.33x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/12/2024 03:57:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,839
            CDSs (total)                      :: 4,716
            Genes (coding)                    :: 4,578
            CDSs (with protein)               :: 4,578
            Genes (RNA)                       :: 123
            rRNAs                             :: 10, 10, 10 (5S, 16S, 23S)
            complete rRNAs                    :: 10, 10, 10 (5S, 16S, 23S)
            tRNAs                             :: 88
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 138
            CDSs (without protein)            :: 138
            Pseudo Genes (ambiguous residues) :: 0 of 138
            Pseudo Genes (frameshifted)       :: 83 of 138
            Pseudo Genes (incomplete)         :: 63 of 138
            Pseudo Genes (internal stop)      :: 20 of 138
            Pseudo Genes (multiple problems)  :: 24 of 138
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:34:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1770339
            Orig. end                         :: 1796635
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP089148.1.
            Bacteria and source DNA available from Kangwon National University.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..26296
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="2"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26296
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26296
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16296](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16296
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            147..956
                     /gene="cdsA"
                     /locus_tag="LRO88_RS09385"
     CDS             147..956
                     /EC_number="2.7.7.41"
                     /codon_start=1
                     /gene="cdsA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389536.1"
                     /locus_tag="LRO88_RS09385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphatidate cytidylyltransferase"
                     /protein_id="WP_003231924.1"
                     /transl_table=11
                     /translation="MVDMKQRILTGVLAAIVFLFLVIVGKLPFTILIYAMGSVALFELL
                     RMKKLKLVSLPGLIGLLLLWMFLLPSQYSFFEADGISKMEIALFAVLLLLTYTVLVKNT
                     FTFDEVGFITLAAIYIGMCFHYFIEIRNLDQYGLTYIFYACVVIWSTDSGAYFVGKSLG
                     KRKLWPEISPNKTVEGFAGGIVIALVLATIFQLVAQLPIPYIYLLLITLFLSVFGQLGD
                     LVESALKRHYDVKDSGNILPGHGGILDRFDSFLFVMPFLYFLLALFS"
     gene            1018..2169
                     /gene="dxr"
                     /locus_tag="LRO88_RS09390"
     CDS             1018..2169
                     /EC_number="1.1.1.267"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0030604 - 1-deoxy-D-xylulose-5-phosphate
                     reductoisomerase activity [Evidence IEA]"
                     /GO_process="GO:0019288 - isopentenyl diphosphate
                     biosynthetic process, methylerythritol 4-phosphate pathway
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="dxr"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389537.2"
                     /locus_tag="LRO88_RS09390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase"
                     /protein_id="WP_003245155.1"
                     /transl_table=11
                     /translation="MKNICLLGATGSIGEQTLDVLRAHQDQFQLVSMSFGRNIDKAVPM
                     IEVFQPKFVSVGDLDTYHKLKQMSFSFECQIGLGEEGLIEAAVMEEVDIVVNALLGSVG
                     LIPTLKAIEQKKTIALANKETLVTAGHIVKEHAKKYDVPLLPVDSEHSAIFQALQGEQA
                     KNIERLIITASGGSFRDKTREELESVTVEDALKHPNWSMGAKITIDSATMMNKGLEVIE
                     AHWLFDIPYEQIDVVLHKESIIHSMVEFHDKSVIAQLGTPDMRVPIQYALTYPDRLPLP
                     DAKRLELWEIGSLHFEKADFDRFRCLQFAFESGKIGGTMPTVLNAANEVAVAAFLAGKI
                     PFLAIEDCIEKALTRHQLLKKPSLADIQEVDKDTRGYVNSILT"
     gene            2176..3444
                     /gene="rseP"
                     /locus_tag="LRO88_RS09395"
     CDS             2176..3444
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene="rseP"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M50"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389538.1"
                     /locus_tag="LRO88_RS09395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RIP metalloprotease RseP"
                     /protein_id="WP_085186057.1"
                     /sec_met_domain="Peptidase_M50 (E-value: 1.3e-83, bitscore:
                     278.2, seeds: 56, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFVNTVIAFIIIFGTLVFFHELGHLLLAQRAGILCREFAIGFGPK
                     IFSFKKNETVYTIRLLPVGGFVRMAGEDPEMIEVKPGYTVGLLFNKEDQVEKVIINQKE
                     KYPDALVIEVETADLEHDMKITGYEQGKEDELSSFTVSETSFFIVDGEEVQIAPYNRQF
                     GSKPVWQRIKAIAAGPIMNFILAYVILVMLGLIQGVPSNEPMLGQLTDNGRAAEAGLKE
                     GDYIQSINGEKMRSWTDIVSAVKENPEKEMDVAVKRDNKTLHISVTPEAVKDENKKTIG
                     RFGSYAPTEKGVLSAVAYGATSTVDIGNQILETFGNLVTGQFKINMLAGPVGIYDMTDQ
                     VAKTGLVNLVRFAAFLSINLGIVNLLPIPALDGGRLLFLFIEAIRGKPINREKEAFVVF
                     IGVAFLMLLMLVVTWNDIQRLFL"
     gene            3477..5171
                     /gene="proS"
                     /locus_tag="LRO88_RS09400"
     CDS             3477..5171
                     /EC_number="6.1.1.15"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004827 - proline-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006433 - prolyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="proS"
                     /gene_functions="other (smcogs) SMCOG1162: threonyl-tRNA
                     synthetase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389539.1"
                     /locus_tag="LRO88_RS09400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="proline--tRNA ligase"
                     /protein_id="WP_003231918.1"
                     /transl_table=11
                     /translation="MRQSLTLIPTLREVPADAEAKSHQLLLRAGFIRQNTSGVYSYMPL
                     AYKVIQNIQQIVREEMEKIDAVEMLMPALQQAETWQESGRWYTYGPELMRLKDRHGREF
                     ALGATHEEVITSLVRDEVKSYKRLPLTLYQIQSKFRDEKRPRFGLLRGREFIMKDAYSF
                     HASAESLDETYQKMYEAYSNIFARCGINVRPVIADSGAMGGKDTHEFMALSAIGEDTIA
                     YSDESQYAANIEMAEVLHQEVPSDEEPKALEKVHTPNVKTIEELTAFLQVSAEACIKSV
                     LFKADDRFVLVLVRGDHEVNDIKVKNLLHAEVVELATHEEVIQQLGTEPGFVGPVGIHQ
                     DVEVYADQAVKAMVNAVAGANEGDHHYKNVNVNRDAQIKEFADLRFIKEGDPSPDGKGT
                     IRFAEGIEVGQVFKLGTRYSEAMNATYLDENGRAQPMLMGCYGIGVSRTLSAIAEQHHD
                     EKGLIWPKSVAPYDLHILALNMKNDGQRELAEKLYADLKAEGYEVLYDDRAERAGVKFA
                     DSDLIGLPIRITVGKRADEGIVEVKIRQTGESTEISVDELSAFISKQ"
     misc_feature    complement(5188..5197)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
     gene            5280..9593
                     /gene="polC"
                     /locus_tag="LRO88_RS09405"
     CDS             5280..9593
                     /EC_number="2.7.7.7"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_function="GO:0008408 - 3'-5' exonuclease activity
                     [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /gene="polC"
                     /gene_functions="other (smcogs) SMCOG1194: DNA polymerase
                     III subunit alpha"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389540.1"
                     /locus_tag="LRO88_RS09405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PolC-type DNA polymerase III"
                     /protein_id="WP_015715890.1"
                     /transl_table=11
                     /translation="MEQLSVNRRQFQILLQQINMTDDTFMTYFEHGEIKKLTIHKASKS
                     WHFHFQFKSLLPFQIYDTLTTRLTQSFAHIAKVTSSIEVQDAEVSESIVQDYWSRCIEE
                     LQGISPPIISLLNQQKPKLKGNKLIVKTKTDTEAAALKNKYSSMIQAGYRQFGFPDLQL
                     DAEIFVSEQEVQKFREQKLAEDQERAMQALIEMEKKDKESDEDQAPSGPLVIGYQIKDN
                     EEIRTLDSIMDEERRITVQGYVFDVETRELKSGRTLCIFKITDYTNSILIKMFAREKED
                     AALMKSLKKGMWVKARGSIQNDTFVRDLVMIANDVNEIKAKTREDSAPEGEKRVELHLH
                     SPMSQMDAVTGIGKLVEQAKKWGHEAIALTDHAVVQSFPDAYSAAKKHGIKMIYGMEAN
                     LVDDGVPIAYNAAHRLLEEETYVVFDVETTGLSAVYDTIIELAAVKVKGGEIIDKFEAF
                     ANPHRPLSATIIELTGITDDMLQDAPDVVDVIRDFREWIGDDILVAHNASFDMGFLNVA
                     YKKLLEVDKAKNPVIDTLELGRFLYPEFKNHRLNTLCKKFDIELTQHHRAIYDTEATAY
                     LLLKMLKDAAEKGIQYHDELNENMGQSNAYQRSRPYHATLLAVNSTGLKNLFKLVSLSH
                     IHYFYRVPRIPRSQLEKYREGLLIGSACDRGEVFEGMMQKSPEEVEDIASFYDYLEVQP
                     PEVYRHLLELELVRDEKALKEIIANITKLGEKLNKPVVATGNVHYLNDEDKIYRKILIS
                     SQGGANPLNRHELPKVHFRTTDEMLEAFSFLGEKKAKEIVVTNTQKVASLVDDIKPIKD
                     DLYTPKIEGADEEIREMSYQRARSIYGEELPEIVEARIEKELKSIIGHGFAVIYLISHK
                     LVKRSLDDGYLVGSRGSVGSSLVATLTEITEVNPLPPHYVCPECQHSEFFNDGSVGSGF
                     DLPDKTCPHCGTPLKKDGHDIPFETFLGFKGDKVPDIDLNFSGEYQPQAHNYTKVLFGE
                     DNVYRAGTIGTVAEKTAYGYVKGYAGDNNLHMRGAEIDRLVQGCTGVKRTTGQHPGGII
                     VVPDYMDIYDFSPIQFPADATGSEWKTTHFDFHSIHDNLLKLDILGHDDPTVIRMLQDL
                     SGIDPKTIPTDDPEVMKIFQGTESLGVTEEQIGCKTGTLGIPEFGTRFVRQMLEDTKPT
                     TFSELVQISGLSHGTDVWLGNAQELIHNNICELSEVIGCRDDIMVYLIYQGLEPSLAFK
                     IMEFVRKGKGLTPEWEEEMKNNNVPDWYIDSCKKIKYMFPKAHAAAYVLMAVRIAYFKV
                     HHALLYYAAYFTVRADDFDIDTMIKGSTAIRAVMEDINAKGLDASPKEKNLLTVLELAL
                     EMCERGYSFQKVDLYRSSATEFIIDGNSLIPPFNSIPGLGTNAALNIVKAREEGEFLSK
                     EDLQKRGKVSKTILEYLDRHGCLESLPDQNQLSLF"
     misc_feature    9706..9723
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 18.97"
                     /tool="antismash"
     gene            9740..9919
                     /locus_tag="LRO88_RS09410"
     CDS             9740..9919
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LRO88_RS09410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_041850827.1"
                     /transl_table=11
                     /translation="MEKDIFDLDLKIQTSKSNVEPNSIRLTFGCSGGVASKALCSRAMC
                     DGIVITKNYGYCDA"
     CDS_motif       9740..9805
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEKDIFDLDLKIQTSKSNVEPN"
                     /locus_tag="LRO88_RS09410_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9806..9919
                     /prepeptide="core"
                     /locus_tag="LRO88_RS09410_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="13.90"
                     /molecular_weight="3724.3"
                     /monoisotopic_mass="3721.8"
                     /core_sequence="SIRLTFGCSGGVASKALCSRAMCDGIVITKNYGYCDA"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEKDIFDLDLKIQTSKSNVEPN"
                     /leader_location="[9739:9805](+)"
                     /alternative_weights="3742.3"
                     /alternative_weights="3760.4"
     gene            10001..13177
                     /locus_tag="LRO88_RS09415"
     CDS             10001..13177
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="LRO88_RS09415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_159376804.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.1e-148,
                     bitscore: 494.2, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 4.6e-07,
                     bitscore: 28.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1e-33, bitscore:
                     115.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSLKKDSLKNIEQKWFSLDSFFIRTPTLSLTFLENYLHKMINGK
                     ESYSNWVKDLINNPIFMEAIYIASPSLYENLKYWKNITDKKRKEQIAISLNNYLLRMTS
                     RTTPFGLFSSVTVGRFENETSINIDPLVHNIKKCNPDMNWLYKLIKKLEKENSIFLELN
                     VKFNNLVEKVGNRYFLSYNSKIDSARQNNITNDISSIIVSPPIEIIEKLTQEPLKIKNI
                     LRYLKKEYSSVTSEKILSLIHNLVDQDYLITDLRPSLLEKSPFNYVINKIKSIEKQDLQ
                     YILQELLSIQAKINYYETLPIGEGLNEVNEIEKLMSNLVVSDIYLQVNLSLNNKSEIKL
                     SNNVKKDLIELTECLEYFSITNNKPRHLKNYLNEFIDKYGEHREVELLELLNNDIGLGS
                     PASYKNPTSTREFIYKSNQKLENYLLRKLLNSIKENEQEIEITLEELKHLNKEKNISDQ
                     NNFVKSFEIFGNIVADNIDSFNKGKYTIFLNSENPVSNFAGKAAGRFTDLLKDKTNVKQ
                     FYDQQTICEHYINAEMSYTPNNGKIANIMMVDNFSDYEINLNNFCSEENETIPIEDIVV
                     GVEEDLFYFKSKNLNKRINISVNSLVNMDITPNVFRFIQEASLFNDQYLTGFNWGRLIE
                     SEFLPRVKFKKTILSPVMWNFNLSDHITEKPNYDEWLKIFKRWAKKWSIPKSVYLVEGD
                     EKLFLNLDVHLHLKILYKKIQKMKIIRLIESEINLSKSWAQDRNKNKYNIEFIFPLIQN
                     KNNNSIGKTKKNKPIIYTNSILTKKQIGSDWLYFKLYFNSFRDEEIIADHIPSFLNQLI
                     NNNQLINKYFYVRYLDDKPHIRLRIQGDPNILLSTVLIKMKDWTSNLIEGGLINKIELS
                     CYEREIERYGGPDFIDICETLFYYDSICVSELFNFLSYTTNELFDKETIAVLSVIFYLE
                     EIGFDYNQQLNLFERILENNKFPKEFRLKKDYLVFLCNSNLNWSNLRKSEDGNKLISIF
                     EKRKKIINHASEEFSVKSNYLYSPTKDIWLSIIHMHLNRLLGVDREKEKNIMLLVKYTL
                     KNLKYQKGIL"
     aSDomain        10499..10774
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_LRO88_RS09415_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.90E-09"
                     /identifier="RREFam001.1"
                     /label="LRO88_RS09415"
                     /locus_tag="LRO88_RS09415"
                     /protein_end="258"
                     /protein_start="166"
                     /score="28.5"
                     /tool="antismash"
                     /translation="NNLVEKVGNRYFLSYNSKIDSARQNNITNDISSIIVSPPIEIIEK
                     LTQEPLKIKNILRYLKKEYSSVTSEKILSLIHNLVDQDYLITDLRPS"
     gene            13174..14985
                     /locus_tag="LRO88_RS09420"
     CDS             13174..14985
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="LRO88_RS09420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_041850825.1"
                     /transl_table=11
                     /translation="MSKFYNVTYKEVISSFNNWPKLYKIFLKVDKISFFQIIIIAVISG
                     FIPPSLLLLNQSLLNNLQRETQINKVLLIFILLIVVYLVQVIVNQYKQYKEEIFANKLA
                     YFINLEILKKTKILELPDFENPHIYDQIQRVTSESSYRPFQIFTEILNILTNIITIIST
                     SIIIIIWKWWVVILLFLTPIISSIFFVKLGKKEYEIEWERTPLRRKIYYYIFLMTRDFN
                     IKEIKLFNLSDLLISRYEKINKVFLKTDKEMAQRKMKVSTIFETVNQLIVGGIMLYIIL
                     KVFSKEIMIGTMMALIQGVISSQTALKTLMQGVFSVYENNLYVNDFFEFVKNRKLNNDT
                     KLEEKIQLTEINKITFNNVSFKYPNKNNYALKKISFELKKGETIAIVGGNGSGKSTLIK
                     LICRLYDGFEGEILINSIPIEKYSIESIRAQTSIIFQDFIKYEFSIRENIGFGNYNEMK
                     NQDFLEYAAYISGANKIINKYPDRFDSQLGKMFNKGHQLSGGEWQKMAISRAIFKKASL
                     YMMDEPSSALDIYSEQELFIKYNEFLKNKIGLFITHRFNTVQLASRILVMNNGEIIECG
                     THKELLQNKGMYYDLYNQQKKVFYSGL"
     gene            15067..16296
                     /locus_tag="LRO88_RS09425"
     CDS             15067..16296
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="LRO88_RS09425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_041850824.1"
                     /sec_met_domain="LANC_like (E-value: 1.3e-59, bitscore:
                     199.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLNNYIDKIIIKTSKQISDLQLVLNLQRLDDISVASGISSVCILF
                     AELDYTFPNRGWDRIGHEYLIHIKKKLEGMEDYSPSCLGGMGGIGFCILALSKNGNRYR
                     NFLTDFNLYYFDIIKKHIEEFKDLSSLQKNDLFLYETIYGFAGIGRYLLFFRDQRESRD
                     LLEKILVLITRMANKNVNSLADEKYVLDCGLAHGVSGPLSLLSLSYINNIIVEGQLDAI
                     KKISNFLIKTKTKSANGYLFPNGIILNEKNKDQTVDITTRDAWCYGSPGTCRALLLAKE
                     ATGDAKYSNCAVTVFKDVIKRNFEQQKNYSPTFCHGLSGLLTITFLFNESIRDPKFKSY
                     QIYLVKKLLGYYNDNNVLGFQNIERDNLNKEIVSDELGILNGVTGVLLTLLAFRNQMTY
                     TRWESILLLN"
     misc_feature    complement(16479..16492)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.81"
                     /tool="antismash"
     gene            16531..17001
                     /gene="rimP"
                     /locus_tag="LRO88_RS09430"
     CDS             16531..17001
                     /GO_process="GO:0042274 - ribosomal small subunit
                     biogenesis [Evidence IEA]"
                     /codon_start=1
                     /gene="rimP"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389541.1"
                     /locus_tag="LRO88_RS09430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ribosome maturation factor RimP"
                     /protein_id="WP_003231915.1"
                     /transl_table=11
                     /translation="MSKKVTDTVQEMAQPIVDSLQLELVDIEFVKEGQSWFLRVFIDSD
                     DGVDIEECAKVSEALSEKLDEADPISQNYFLEVSSPGAERPLKKKADFEKSLGKNVYIK
                     TYEPIDGVKVFEGELAEFDGQTVTVEITIKTRKKRINIPYEKIANARLAVTF"
     gene            17036..18151
                     /gene="nusA"
                     /locus_tag="LRO88_RS09435"
     CDS             17036..18151
                     /GO_process="GO:0006353 - DNA-templated transcription
                     termination [Evidence IEA]"
                     /codon_start=1
                     /gene="nusA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389542.1"
                     /locus_tag="LRO88_RS09435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transcription termination factor NusA"
                     /protein_id="WP_003231912.1"
                     /transl_table=11
                     /translation="MSSELLDALTILEKEKGISKEIIIEAIEAALISAYKRNFNQAQNV
                     RVDLNRETGSIRVFARKDVVDEVYDQRLEISIEEAQGIHPEYMVGDVVEIEVTPKDFGR
                     IAAQTAKQVVTQRVREAERGVIYSEFIDREEDIMTGIVQRLDNKFIYVSLGKIEALLPV
                     NEQMPNESYKPHDRIKVYITKVEKTTKGPQIYVSRTHPGLLKRLFEIEVPEIYDGTVEL
                     KSVAREAGDRSKISVRTDDPDVDPVGSCVGPKGQRVQAIVNELKGEKIDIVNWSSDPVE
                     FVANALSPSKVLDVIVNEEEKATTVIVPDYQLSLAIGKRGQNARLAAKLTGWKIDIKSE
                     TDARELGIYPRELEEDDEPLFTEPETAESDE"
     gene            18165..18440
                     /gene="rulR"
                     /gene_synonym="ylxR"
                     /locus_tag="LRO88_RS09440"
     CDS             18165..18440
                     /codon_start=1
                     /gene="rulR"
                     /gene_synonym="ylxR"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389543.1"
                     /locus_tag="LRO88_RS09440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glucose-induced regulator RulR"
                     /protein_id="WP_009967250.1"
                     /transl_table=11
                     /translation="MNKHKKIPLRKCVVTGEMKPKKELIRVVRSKEGEISVDPTGKKNG
                     RGAYLTLDKECILAAKKKNTLQNQFQSQIDDQIFDELLELAEKVKK"
     gene            18442..18744
                     /gene="rulQ"
                     /locus_tag="LRO88_RS09445"
     CDS             18442..18744
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /codon_start=1
                     /gene="rulQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389544.1"
                     /locus_tag="LRO88_RS09445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YlxQ family RNA-binding protein"
                     /protein_id="WP_003220946.1"
                     /transl_table=11
                     /translation="MSGMEWFPLLGLANRARKVVSGEDLVIKEIRNARAKLVLLTEDAS
                     SNTAKKVTDKCNYYKVPYKKVESRAVLGRSIGKEARVVVAVTDQGFANKLISLLD"
     gene            18764..20914
                     /gene="infB"
                     /locus_tag="LRO88_RS09450"
     CDS             18764..20914
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0003743 - translation initiation factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006413 - translational initiation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="infB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190: GTP-binding protein LepA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389545.1"
                     /locus_tag="LRO88_RS09450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="translation initiation factor IF-2"
                     /protein_id="WP_231834273.1"
                     /transl_table=11
                     /translation="MAKMRVYEYAKALNVSSKEILTALKNMDLEVNNHMAMLEEKAIKK
                     LDAKYKKGGAAAKSQKPAETNKNKQPQGVNQQSAGNQPNKIRDGKKNDVQNNQFNKNKK
                     NNNNKKNKRNNNNNKNQHQQKPVKPKKELPEKITFSGTLTVGALAEELGKEPSEIIKKL
                     MLLGVMATINQELDKDTIELIASEYGVETEEVIVLEETELEKYEEPDNEEDLEIRPPVV
                     TIMGHVDHGKTTLLDSIRKTKVVEGEAGGITQHIGAYQIEENGKKITFLDTPGHAAFTT
                     MRARGAEVTDITILVVAADDGVMPQTVEAINHAKAAEVPIIVAVNKIDKESANPDRVMQ
                     ELTEYGLVPEAWGGETIFVPLSALTGKGIDELVEMILLVSEVEELKANPNRQAKGTVIE
                     AELDKGRGSVATLLVQTGTLHVGDPIVVGNTFGRVRAMVNDIGRRVKTAGPSTPVEITG
                     LNDVPQAGDQFLVFKDEKTARSVGEARASKQLEEQRSDKAKLSLDDLFEQIKQGDVKDI
                     NLIVKADVQGSAEALTAALQKIEVEGVKVKIIHTGVGAITESDIILASASNAIVIGFNV
                     RPDGNAKSTAEAENVDIRLHRIIYKVIDEIEAAMKGMLDPEYEEKVIGQVEVRQTFKVS
                     KIGTIAGGYVTEGTITRDSGLRLIRDGVVIFEGEVDVLKRFKDDVKEVSQGYECGITIK
                     EYNDIREGDILEAFVMQEIERT"
     gene            20911..21189
                     /locus_tag="LRO88_RS09455"
     CDS             20911..21189
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003328897.1"
                     /locus_tag="LRO88_RS09455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF503 domain-containing protein"
                     /protein_id="WP_003231905.1"
                     /transl_table=11
                     /translation="MIGFAECECIIYDAGSLKEKRAVLKRVLTRVQNKFNVSISEIGYQ
                     DTWQRTSFGIAAVSSSRVQTEKELQRVLAFIDSFPEIERTITRTEWF"
     gene            21206..21559
                     /gene="rbfA"
                     /locus_tag="LRO88_RS09460"
     CDS             21206..21559
                     /GO_function="GO:0019843 - rRNA binding [Evidence IEA]"
                     /GO_process="GO:0006396 - RNA processing [Evidence IEA]"
                     /codon_start=1
                     /gene="rbfA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389547.1"
                     /locus_tag="LRO88_RS09460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="30S ribosome-binding factor RbfA"
                     /protein_id="WP_009967251.1"
                     /transl_table=11
                     /translation="MSMRANRVGEQMKKELGDIISRKLKDPRIGFLTVTDVRVSGDLQI
                     AKVYISVLGDEKKREEALKGLAKAKGFIRSEIGSRIRLRKTPEIEFEFDESIDYGNRIE
                     TLIHELHSEKPSE"
     gene            21641..22570
                     /gene="truB"
                     /locus_tag="LRO88_RS09465"
     CDS             21641..22570
                     /EC_number="5.4.99.25"
                     /GO_function="GO:0004730 - pseudouridylate synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="truB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389548.1"
                     /locus_tag="LRO88_RS09465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tRNA pseudouridine(55) synthase TruB"
                     /protein_id="WP_015715891.1"
                     /transl_table=11
                     /translation="MVNGVLLLHKPVGMTSHDCVMKIRKLLKTKKVGHTGTLDPEVSGV
                     LPICVGRATKIVEYLTEKSKTYDAEITLGFSTTTEDQTGETVEAKPVNHDIDKADVEKV
                     LNSLKGKQEQIPPMYSAVKVNGKKLYEYARAGIEVERPKRMITIEDIALTTEIKHHGET
                     ASFRFTVTCSKGTYVRTLAVMIGEKLGYPAHMSHLIRTASGDFSLDECFTFDELEAQAQ
                     SGTVEEHTVPIERALNHLPKWIISDTLAKKVENGALLETPEQFSEMTSEDRIAVFTESG
                     TCLAIYFPHPAKKGLLKPAKVLMQKSEQ"
     gene            22589..23539
                     /gene="ribF"
                     /locus_tag="LRO88_RS09470"
     CDS             22589..23539
                     /EC_number="2.7.1.26"
                     /EC_number="2.7.7.2"
                     /codon_start=1
                     /gene="ribF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CTP_transf_like"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389549.1"
                     /locus_tag="LRO88_RS09470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bifunctional riboflavin kinase/FAD synthetase"
                     /protein_id="WP_014476827.1"
                     /sec_met_domain="CTP_transf_like (E-value: 1.1e-05,
                     bitscore: 23.7, seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTIHITHPHHLIKEEQAKSVMALGYFDGVHLGHQKVIGTAKQIA
                     EEKGLTLAVMTFHPHPSHVLGRDKEPKDLITPLEDKINQIEQLGTEVLYVVKFNEVFAS
                     LSPKQFIDQYIIGLNVQHAVAGFDFTYGKYGKGTMETMPDDLDGKAGCTMVEKLTEQDK
                     KISSSYIRTALQNGDVELANVLLGQPYFIKGIVIHGDKRGRTIGFPTANVGLNNSYIVP
                     PTGVYAVKAEVNGEVYNGVCNIGYKPTFYEKRPEQPSIEVNLFDFDQEVYGAAIKIEWY
                     KRIRSERKFNGIKELTEQIEKDKQEAIRYFSNLRK"
     misc_feature    complement(23557..23570)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.31"
                     /tool="antismash"
     gene            23696..23965
                     /gene="rpsO"
                     /locus_tag="LRO88_RS09475"
     CDS             23696..23965
                     /GO_component="GO:0000314 - organellar small ribosomal
                     subunit [Evidence IEA]"
                     /GO_component="GO:0022627 - cytosolic small ribosomal
                     subunit [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpsO"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010898561.1"
                     /locus_tag="LRO88_RS09475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="30S ribosomal protein S15"
                     /protein_id="WP_003220957.1"
                     /transl_table=11
                     /translation="MAITQERKNQLINEFKTHESDTGSPEVQIAILTDSINNLNEHLRT
                     HKKDHHSRRGLLKMVGKRRNLLTYLRNKDVTRYRELINKLGLRR"
     gene            24138..26255
                     /gene="pnp"
                     /locus_tag="LRO88_RS09480"
     CDS             24138..26255
                     /EC_number="2.7.7.8"
                     /GO_function="GO:0004654 - polyribonucleotide
                     nucleotidyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0006402 - mRNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pnp"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389551.1"
                     /locus_tag="LRO88_RS09480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyribonucleotide nucleotidyltransferase"
                     /protein_id="WP_021479284.1"
                     /transl_table=11
                     /translation="MGQEKHVFTIDWAGRTLTVETGQLAKQANGAVMIRYGDTAVLSTA
                     TASKEPKPLDFFPLTVNYEERLYAVGKIPGGFIKREGRPSEKAVLASRLIDRPIRPLFA
                     DGFRNEVQVISIVMSVDQNCSSEMAAMFGSSLALSVSDIPFEGPIAGVTVGRINDQFII
                     NPTVDQLEKSDINLVVAGTKDAINMVEAGADEVPEEIMLEAIMFGHEEIKRLIAFQEEI
                     VAAVGKEKSEIKLFEIDEELNEKVKALAEEDLLKAIQVHEKHAREDAINEVKNAVVAKF
                     EDEEHDEDTIKQVKQILSKLVKNEVRRLITEEKVRPDGRGVDQIRPLSSEVGLLPRTHG
                     SGLFTRGQTQALSVCTLGALGDVQILDGLGVEESKRFMHHYNFPQFSVGETGPMRGPGR
                     REIGHGALGERALEPVIPSEKDFPYTVRLVSEVLESNGSTSQASICASTLAMMDAGVPI
                     KAPVAGIAMGLVKSGEHYTVLTDIQGMEDALGDMDFKVAGTEKGVTALQMDIKIEGLSR
                     EILEEALQQAKKGRMEILNSMLATLSESRKELSRYAPKILTMTINPDKIRDVIGPSGKQ
                     INKIIEETGVKIDIEQDGTIFISSTDESGNQKAKKIIEDLVREVEVGQLYLGKVKRIEK
                     FGAFVEIFSGKDGLVHISELALERVGKVEDVVKIGDEILVKVTEIDKQGRVNLSRKAVL
                     REEKEKEEQQS"
ORIGIN
        1 ggctgagtaa ttttatgcta tggcaggttg cctacagtga atttgtcttt actgacgtct
       61 tgtggcctga ctttaaagaa gatcacttct tgcaggcgtt aggagagttt cagcagagag
      121 gccggaggtt tggcggaatt tagaggatgg tggacatgaa acaaagaatt ttgacaggtg
      181 ttctggcagc aattgtattt ttatttttgg ttattgtcgg gaaattgccg ttcaccatat
      241 taatttatgc tatgggcagt gtggcgcttt ttgaactttt acggatgaaa aagctgaagc
      301 tggtttcact gccgggtttg atcggtcttt tattattgtg gatgttctta ttgccaagcc
      361 agtattcgtt ttttgaagcg gacggaattt ccaaaatgga aatcgcttta tttgcggtac
      421 tgctattgct gacttacaca gtgttggtca agaacacctt tacttttgat gaagtcgggt
      481 ttattacgct tgcagcaatt tacatcggaa tgtgttttca ttattttatc gaaatcagaa
      541 atcttgacca atacggatta acatacattt tttatgcgtg tgttgtcatt tggtccaccg
      601 attccggtgc ctattttgtc ggtaaatcgc ttgggaagcg gaaactgtgg cctgaaatca
      661 gtccgaataa aacagtggaa gggtttgcag gcggaattgt catcgcactt gtattggcga
      721 cgatttttca gcttgttgca caacttccga tcccgtatat ctatctgctg ttgatcacgc
      781 tgtttttgtc tgtttttgga caactgggag atttagtgga atccgccttg aaaagacatt
      841 acgatgtaaa ggattctggg aatattcttc ccgggcatgg cggtatatta gaccgttttg
      901 acagtttctt gtttgtcatg cctttcttgt actttctgct tgcccttttt tcataaaaaa
      961 gtctaatatg aatatgagac tgatcatgca gcaataagaa taggagtagt ggcaactttg
     1021 aaaaatattt gtcttttagg agcaacagga tcaatcggcg aacagactct tgatgtactg
     1081 cgtgcacatc aagaccaatt tcagctggta tctatgtcgt ttggcagaaa tattgataag
     1141 gccgttccaa tgattgaggt ctttcagccg aagtttgtct ctgtcggtga tctggataca
     1201 tatcataaat taaaacaaat gtctttttct tttgaatgcc aaatcgggct gggagaagaa
     1261 ggactgatag aagcagcagt gatggaggag gttgacattg ttgtcaacgc tttgcttgga
     1321 agcgtcggtc ttatcccgac attaaaggca attgaacaga aaaaaacaat tgcgcttgca
     1381 aataaggaaa ctcttgtcac tgcagggcat atagtaaaag aacatgctaa gaaatatgat
     1441 gttccgctgc tgcctgttga cagtgagcat tcagccattt ttcaagctct tcaaggcgaa
     1501 caggctaaaa acattgaacg cctcatcatt acggcatccg gcggaagttt tcgggacaag
     1561 acgcgggagg agctcgaatc agtaacagtt gaagatgcat taaaacatcc aaactggtca
     1621 atgggtgcaa aaattacaat tgattcggct acaatgatga ataagggatt agaggtgatc
     1681 gaggcacact ggcttttcga tataccttat gaacaaattg atgtggtttt acataaggag
     1741 agcatcatcc attcaatggt tgagttccat gataaaagtg tgatcgcaca gctcggaact
     1801 ccggatatga gagtccccat tcaatatgcg ctcacttatc ctgaccgatt gccattacca
     1861 gatgcgaaaa ggcttgaatt atgggaaatc ggcagccttc attttgagaa agctgatttt
     1921 gacaggttcc gatgcttaca atttgctttt gaatcaggta aaataggagg aacaatgccg
     1981 acagtgctaa atgcggcaaa cgaagtagct gtcgctgcct ttttagctgg caagataccg
     2041 tttttggcta ttgaagactg tatcgaaaag gcactaaccc gccatcaatt actgaaaaaa
     2101 ccgagcctgg cggacattca agaagtggac aaagataccc ggggatacgt caattcaata
     2161 ctcacataag gtggtatgtt cgtgaataca gttatagcgt ttatcattat tttcggaacg
     2221 ctcgttttct tccatgaact gggccattta ttgctagccc aaagagcggg aattctctgc
     2281 cgtgaatttg cgatcggctt cggtccaaag attttttctt tcaaaaaaaa tgaaacagtt
     2341 tatacgatca ggctgcttcc ggtcggcgga tttgttcgta tggccggcga agatccggaa
     2401 atgattgagg tgaaacccgg atacacggtc gggcttctgt ttaataagga agatcaagtt
     2461 gagaaagtca tcatcaatca aaaggaaaaa tatccggatg cattagtcat tgaagtggaa
     2521 acagcggatc tagagcatga catgaagatc accggttatg aacaggggaa agaggacgaa
     2581 ctttccagct ttactgtcag cgaaacatcc ttttttattg tagacggaga agaagtgcag
     2641 attgcgccgt ataatcgcca atttggttcc aaacctgtat ggcagcggat taaagcaatt
     2701 gctgcagggc cgattatgaa ctttatttta gcttacgtca ttttagtgat gcttgggctg
     2761 attcaaggcg taccgtcaaa tgaacctatg ctcgggcagc tgacagacaa tggacgggct
     2821 gctgaagcag ggctaaaaga aggggattat atccaaagca ttaacggaga gaaaatgagg
     2881 tcttggactg acattgtctc cgctgtaaaa gaaaacccgg agaaagaaat ggacgttgcg
     2941 gtaaaaagag ataacaaaac gcttcatatt tcggtgactc cggaagctgt taaagatgag
     3001 aacaaaaaaa caatcggccg tttcggttcc tatgcgccga ctgaaaaagg cgtactctca
     3061 gcggttgctt acggcgcgac atcaacagtt gacattggca atcaaatctt agaaacgttt
     3121 ggtaatttag taacaggaca atttaaaata aatatgttgg cgggaccagt tggtatttat
     3181 gatatgacag accaagtggc gaaaaccggg ttagttaatt tggttcgttt cgctgcgttt
     3241 ttaagcatta atcttgggat tgtcaacctg cttccgattc cggcacttga cggaggaaga
     3301 ctgttgtttc tatttattga agcgattcgg ggcaaaccga ttaacaggga aaaagaagca
     3361 tttgttgtgt ttatcggagt agctttctta atgcttctta tgctggttgt cacatggaac
     3421 gatatccagc ggctgttttt gtaaacgaaa agtaaatcaa tcagaggtgc gaagaaatga
     3481 gacaaagctt gacgcttatt cctacgctcc gtgaagttcc agctgatgcc gaagcaaaaa
     3541 gtcatcagct tcttctgaga gcaggattta tcagacagaa tacgagcggg gtatacagct
     3601 atatgcctct tgcgtataag gtgattcaaa acattcagca gattgttcga gaagaaatgg
     3661 agaaaattga tgccgtagaa atgctcatgc ctgcgttgca gcaggcagag acatggcagg
     3721 aatcaggcag atggtatacg tatggtcccg aactgatgag actaaaagac cgtcatggcc
     3781 gtgaatttgc tttaggggca acgcatgaag aggttatcac ttcgcttgtt cgcgatgagg
     3841 ttaaatctta taagcgtctc cctctgactc tttatcaaat tcagtctaag ttcagagatg
     3901 aaaaacgtcc tcgcttcggt ttgttaagag gccgcgaatt tattatgaag gatgcgtact
     3961 ctttccatgc atctgcagag agcctggatg aaacgtatca aaaaatgtac gaggcctatt
     4021 ctaatatttt tgcccgctgc ggcattaatg taagacctgt tatcgctgat tcaggcgcaa
     4081 tgggaggaaa ggatacgcac gaatttatgg cactttctgc gatcggagag gatacgattg
     4141 cgtattctga tgaatcacag tacgcggcta atatcgagat ggctgaagtt cttcaccagg
     4201 aagttccttc agatgaagag cctaaagctc tagagaaggt tcatacgcct aacgtgaaaa
     4261 caatcgaaga actgactgcg ttcttacagg tttcggctga agcgtgcatt aagtcagtat
     4321 tgtttaaagc tgatgaccgt tttgtcttag tgcttgtaag aggggatcat gaagttaacg
     4381 atattaaagt gaaaaacttg cttcatgcag aagttgtaga gcttgctaca catgaagagg
     4441 tcattcagca gctcggaaca gagccaggtt ttgtaggccc tgttggtatt catcaggatg
     4501 tggaagtata tgccgatcaa gctgtgaaag caatggttaa tgctgttgcc ggggcaaatg
     4561 aaggagatca tcattataaa aatgtcaatg tgaatcgtga cgcgcaaatt aaagaatttg
     4621 ctgatcttcg ttttattaaa gaaggtgatc cttcaccaga cggcaaggga acgatccgtt
     4681 ttgctgaggg aatcgaagtc ggacaagtct ttaagctcgg aacacgctat tcagaagcga
     4741 tgaatgcgac atatttagat gaaaacggac gcgcgcagcc aatgctgatg ggctgttacg
     4801 gaatcggtgt gtcaagaacg ctttctgcta ttgctgaaca gcatcacgac gaaaaaggat
     4861 taatatggcc aaaaagcgtt gccccgtacg atcttcatat tcttgcattg aacatgaaaa
     4921 acgatgggca aagagagctt gctgaaaagc tgtatgccga tttaaaagcg gaaggctatg
     4981 aagtgctcta tgacgaccgt gctgagcgtg ccggtgtaaa attcgctgat tcagatctaa
     5041 tcggccttcc aatccgcatc actgtcggaa aacgggctga cgaaggaatc gtcgaagtga
     5101 aaattcgtca aactggtgag tcaactgaga tttcagtaga cgaattatct gcgtttatca
     5161 gcaagcagta atcaccataa cgatttatca aaaaacatgt taaaatagaa ataatagaag
     5221 gtacctcatt gcctgaggta ccttcactta tgatgttttt agggagggat actgtcttaa
     5281 tggaacagtt atcagtaaac agaaggcagt ttcaaattct tctgcagcag attaatatga
     5341 cagatgatac cttcatgaca tactttgaac atggcgagat taaaaagctg acaattcaca
     5401 aagcttctaa atcttggcat tttcattttc aatttaaatc tttgctgcct tttcaaatat
     5461 atgacacatt aacaacgagg ctgacgcaat cgtttgccca catagcaaaa gtgacatctt
     5521 caattgaagt tcaggatgcc gaggtcagtg aaagtatcgt tcaagactac tggtcacgct
     5581 gcattgaaga actgcagggc atttcgccgc cgatcatcag tcttttaaac cagcaaaaac
     5641 cgaagctgaa gggcaataaa ctgattgtca aaaccaaaac ggatacagaa gcggctgcgc
     5701 taaagaacaa atacagttcc atgatacaag caggctaccg tcaatttggc tttccagatc
     5761 ttcagcttga tgctgaaata tttgtatccg agcaggaagt tcaaaagttt cgggagcaaa
     5821 agcttgcaga agaccaagag cgggctatgc aggccttgat tgaaatggag aagaaagata
     5881 aagaaagtga tgaagaccaa gcaccatctg gtcctcttgt tatcggttat caaattaaag
     5941 ataacgagga aattcggaca cttgacagca tcatggacga agaacggaga attacggtcc
     6001 aaggttatgt gtttgatgtg gagacgcgcg agctgaagag cgggcgcacg ctgtgtatct
     6061 tcaaaattac agactataca aatagtattt tgatcaaaat gtttgcacgt gaaaaagaag
     6121 atgcggcact gatgaagtct ctgaaaaaag gaatgtgggt aaaagcacgc ggaagcattc
     6181 aaaatgatac atttgtcaga gaccttgtca tgatcgcaaa tgacgtaaac gaaataaaag
     6241 caaaaacccg tgaagattca gcacctgaag gagaaaaaag agtggaattg catcttcatt
     6301 ccccaatgag ccaaatggat gctgttacgg gtattggaaa gcttgtcgaa caggcgaaaa
     6361 aatgggggca tgaggccatc gctttgactg accatgctgt cgttcaatcc ttccctgatg
     6421 cgtattctgc ggccaaaaag catggaatta aaatgattta cgggatggaa gcgaatctcg
     6481 tggatgatgg cgtgccaatt gcttataatg ccgcacatcg tctgctcgaa gaagaaacat
     6541 atgttgtttt tgacgttgag acgacaggat tgtctgctgt atacgatacc attattgagc
     6601 tggctgcagt aaaagtaaaa ggcggagaaa ttattgataa atttgaggcg tttgcgaacc
     6661 cgcatcgtcc gctttccgcc acaatcatag agctgacagg gatcactgat gatatgctac
     6721 aagacgctcc ggatgtcgta gatgtaataa gagatttcag agaatggatt ggcgatgata
     6781 tccttgtcgc tcataatgca agctttgata tgggattctt aaatgtagcc tataaaaagc
     6841 ttcttgaagt cgataaagct aaaaacccag tcattgacac gctagaacta ggacgttttc
     6901 tctatccgga atttaagaac caccggctga acacactttg taaaaagttt gatatcgaac
     6961 tcacacagca tcaccgtgcg atctatgata ctgaggcaac cgcttatttg cttctgaaaa
     7021 tgctgaaaga cgcggctgaa aaaggtattc agtaccatga tgagttgaat gaaaatatgg
     7081 gtcagtccaa tgcttatcaa agatcaagac cgtatcatgc aacattactt gccgtgaaca
     7141 gcacgggact taaaaattta tttaagcttg tgtcactttc tcatattcat tatttttaca
     7201 gagtgccgcg tattccgaga tctcagcttg agaaatacag ggaagggctg ctgatcggtt
     7261 ctgcctgtga caggggagag gtttttgagg gaatgatgca aaaatcgcct gaagaggtgg
     7321 aagatatcgc gtcattctat gattaccttg aggttcagcc gcctgaagtg tatcgtcact
     7381 tgctggagct tgaactggtc cgtgatgaaa aagcgctgaa agaaattatt gcgaatatca
     7441 cgaagctggg ggaaaagctt aataaaccgg ttgttgctac gggaaatgtt cattacttga
     7501 atgatgagga taaaatctac agaaagattt taatatcctc acaaggcggg gcaaatccgc
     7561 tgaataggca tgaactgccg aaagtgcatt tcagaacgac agacgaaatg cttgaagctt
     7621 tttctttctt aggtgaaaaa aaagcgaagg agatcgtagt caccaatacc caaaaggttg
     7681 cttctttagt tgatgacatc aagccgatta aagatgattt atatacgccg aaaatcgaag
     7741 gcgctgatga agagatcaga gaaatgagct atcagcgtgc aagaagcatt tacggggaag
     7801 agctgcctga aattgtcgaa gcgcggattg aaaaagagtt aaagagtatt attggccacg
     7861 gatttgctgt tatttacttg atctctcaca aacttgtaaa acgttcacta gatgacgggt
     7921 atctcgttgg ttcccgtggt tccgtaggat cttcattagt tgcgacactt actgagatta
     7981 ctgaggtaaa cccgctgccg ccgcactatg tttgtcctga gtgccagcat tctgagttct
     8041 ttaatgacgg ttctgtcggt tccggttttg acctgcctga caagacatgc cctcattgcg
     8101 gaacgccttt gaaaaaagac ggccatgata ttccatttga aacgttctta ggatttaaag
     8161 gggacaaagt acctgatatc gatttgaact tctcagggga atatcagccg caagcacaca
     8221 attacacaaa agtattgttc ggggaagaca atgtatatcg tgcgggaaca ataggcacgg
     8281 tggcagaaaa aacagcctac ggttatgtaa aaggctatgc cggagacaac aatcttcata
     8341 tgcgcggtgc cgaaatagat cggctcgtac agggatgcac aggtgtaaaa cgtacaactg
     8401 gacaacaccc tggcggtatt atcgtagttc cggattatat ggatatttat gatttttcac
     8461 cgatccagtt cccggcagat gccacaggtt cagagtggaa aacgactcat tttgatttcc
     8521 actccatcca tgacaacctg ttaaaacttg atattctcgg acacgatgac ccgactgtta
     8581 ttcggatgct tcaagactta agcggaatag atccgaaaac aattccgacg gatgatcctg
     8641 aagtgatgaa gatcttccag ggaaccgaat cactcggtgt gactgaagaa cagattggct
     8701 gtaaaacggg cactcttgga attcctgaat tcggaacccg atttgtccgg cagatgcttg
     8761 aagatacaaa gccgaccact ttttctgagc tcgttcagat ttcaggcttg tctcacggaa
     8821 ctgatgtatg gcttggcaat gcacaggagc tcatccacaa taatatttgt gagctgagtg
     8881 aggttatcgg ctgccgtgat gacattatgg tttatttaat ctatcaaggc cttgaaccgt
     8941 cccttgcctt taaaatcatg gaattcgtgc gtaaaggaaa aggattaacg cctgaatggg
     9001 aagaagaaat gaaaaataac aatgtcccag actggtatat tgattcttgt aaaaagatta
     9061 aatacatgtt cccgaaagcc cacgccgcgg catatgtctt aatggcagtc cgcattgctt
     9121 actttaaagt gcatcatgct cttttgtatt atgcggctta ttttaccgtt cgtgcagatg
     9181 actttgatat tgatacaatg atcaagggct ctacagcaat cagagcggta atggaggata
     9241 taaacgctaa aggactcgat gcttcaccga aggaaaagaa ccttctgact gttttagaat
     9301 tagcgcttga gatgtgtgag agaggctatt cattccaaaa agtcgattta tatcgctcca
     9361 gcgctacaga gtttattatt gacggcaaca gtcttattcc gccgtttaac tctattccag
     9421 ggttagggac gaacgctgct ttgaacattg taaaagctcg cgaagaaggc gaattcctct
     9481 caaaagaaga tttgcaaaag agagggaaag tatcaaaaac gattttagag tacttagatc
     9541 gccatggctg tctggagtca ctgcctgatc aaaatcaatt gtcactgttt taaaataaaa
     9601 aagacacagt tttcttaatt gtgtcttttt ctgttttgaa aataattaaa atataaacaa
     9661 ttaagtcgaa tgttaaagta taatattgac atataaacaa aatatatgtt acatttctat
     9721 taaaagggag gtgattggtt tggaaaagga tatttttgat ttagatttga aaattcaaac
     9781 gagcaaatcg aatgtagaac ctaatagtat tcgacttacc tttggttgca gtggtggtgt
     9841 cgcttcaaaa gctctctgtt ctcgggcaat gtgtgatggt atcgttatta ctaaaaacta
     9901 tgggtattgt gatgcttaat attttgggtg aagatagtat tatcttcacc tctttggtaa
     9961 gttgtttaat taaatttgtt ataaagagag tgttgtttat atgaaatcac taaagaaaga
    10021 tagtttaaag aatatagagc agaaatggtt ctctttagat agtttcttta ttagaactcc
    10081 tactttatct ctaacctttc ttgaaaatta tttacataaa atgataaatg gaaaagaaag
    10141 ttactctaac tgggtgaaag atttaattaa taatccaatt tttatggaag ctatttatat
    10201 tgccagtcct tcattatatg agaatttaaa atattggaaa aatataacgg acaaaaaaag
    10261 gaaagagcaa atagcaatat cattaaataa ttatttattg cggatgacct ctagaacaac
    10321 tccttttggg cttttctcca gtgttactgt tggaagattc gagaatgaaa cctcaattaa
    10381 tatagatcct cttgtacata atattaagaa gtgcaaccca gatatgaatt ggttatataa
    10441 gttgataaaa aaattagaaa aagaaaattc gattttttta gagcttaatg taaaattcaa
    10501 caacttagtt gagaaagtag ggaaccgtta ttttctttcc tataattcaa aaattgattc
    10561 tgcacgtcaa aataacataa caaatgacat aagctcaatc attgttagtc ctcctattga
    10621 aattatagag aagttaacac aagaacctct taaaataaaa aatatattaa ggtatttaaa
    10681 aaaagagtat tcctcagtaa ctagcgagaa aatattatct ttaatacaca atttagtaga
    10741 tcaagattac ttaattacag acttaagacc atctctgttg gagaaatcgc cgtttaatta
    10801 tgtgatcaat aaaattaaaa gtattgaaaa acaagattta caatatatcc ttcaggagtt
    10861 attatcaata caagctaaaa taaattatta tgaaaccttg ccaattggag aaggcttaaa
    10921 tgaagtcaac gagatcgaaa aactaatgag caatcttgtt gttagcgata tttacttaca
    10981 agttaatttg agtttaaata ataaaagtga gattaaatta agtaataatg taaaaaaaga
    11041 tttaatagaa ctgacagagt gtttagagta cttttctata acaaataata aacctcgaca
    11101 tctaaaaaac tatctaaatg aatttataga taagtatgga gagcatcgcg aggttgaatt
    11161 attagaatta ttaaataatg atatcggatt aggatctcca gcaagttata aaaatcctac
    11221 gagtactaga gagtttatct ataagagtaa tcaaaagttg gaaaactatt tgttaagaaa
    11281 gttacttaat tctataaaag aaaatgagca agaaattgaa attacattgg aagaactaaa
    11341 acatttaaat aaagaaaaaa atataagtga ccaaaataat ttcgttaaat cgtttgaaat
    11401 attcggaaat attgtagctg ataatattga ttcctttaat aaaggaaagt atacaatatt
    11461 ccttaactct gaaaacccag tttctaactt tgcaggaaaa gccgcgggta gatttactga
    11521 tcttttaaaa gataaaacta atgtaaaaca attctatgac caacaaacaa tttgtgagca
    11581 ttatattaat gccgaaatga gttacacccc taataatggt aaaatagcca atattatgat
    11641 ggtagataat ttttccgact atgaaattaa ccttaacaac ttttgttctg aggaaaatga
    11701 aactattcca attgaggata tagttgtcgg cgtagaagag gatttatttt attttaaatc
    11761 caaaaactta aataagagaa ttaatattag cgtaaatagt ctagttaata tggatataac
    11821 tccaaatgta tttagattta tacaagaagc ttcattattt aatgatcaat atcttacagg
    11881 atttaattgg ggaagactaa tagaaagtga atttttacca agagttaaat tcaaaaaaac
    11941 aatattatcc cctgtaatgt ggaattttaa tttaagtgat catattacgg aaaaacctaa
    12001 ttatgatgaa tggttaaaaa tttttaaaag atgggcaaaa aaatggagta ttcctaaaag
    12061 tgtatattta gttgaaggtg atgaaaaatt atttttaaat ctagacgttc atcttcactt
    12121 gaaaatactg tataaaaaaa tccaaaaaat gaagattatt agattaatcg aaagtgaaat
    12181 taatttgtca aagtcatggg cacaagatag gaataaaaat aaatataaca tagagtttat
    12241 ttttcctctc atacaaaata aaaataataa tagtataggc aaaactaaaa agaataaacc
    12301 cattatttat actaatagta ttcttacaaa aaaacaaata ggcagtgatt ggttgtattt
    12361 caaattgtac tttaattcat ttagagatga agaaataatt gctgaccata ttccgtcttt
    12421 tttaaatcaa ttaattaata ataatcaatt aattaataaa tatttttatg tgcgttattt
    12481 agatgataaa ccgcatataa gattacgaat acagggagac cccaacattc ttttgtcgac
    12541 tgtattaata aaaatgaaag actggacatc aaatctaatt gaaggaggtt taattaataa
    12601 aatcgaatta tcttgctatg aaagagaaat tgaacgatat ggaggacctg attttataga
    12661 tatttgtgag actttatttt attatgatag catctgtgtc tctgagctat tcaatttttt
    12721 atcgtatact actaatgagt tatttgataa agagacaatt gcagttctta gtgtcatttt
    12781 ctacttagaa gaaataggtt ttgattataa tcaacaactt aatctttttg aaagaatttt
    12841 agagaataat aaatttccta aggaatttag attaaagaaa gactatttag ttttcctatg
    12901 taactcaaat ctaaattgga gtaacctaag aaaaagcgaa gatggaaata aattaattag
    12961 tattttcgaa aaaagaaaaa aaataattaa tcatgccagc gaagaatttt ctgttaaaag
    13021 caattattta tatagtccta ctaaagatat ttggttgagt ataattcata tgcatttaaa
    13081 tagattatta ggagtggata gggaaaaaga gaaaaatatt atgctgcttg taaaatatac
    13141 acttaaaaat cttaaatacc aaaagggaat actatgagta aattttataa tgttacttat
    13201 aaagaagtaa ttagttcttt taataattgg ccaaaattat ataagatttt tcttaaggta
    13261 gataaaataa gtttctttca aatcattata attgctgtta taagtggatt tattccacct
    13321 tctttattac ttctaaatca atcgctttta aataatttac aaagagaaac acaaataaat
    13381 aaagtattac ttattttcat attattaata gtggtttatt tagtgcaggt tatcgttaat
    13441 caatataaac aatataaaga ggagatcttt gcaaataagt tagcctattt tattaacttg
    13501 gaaattttaa agaaaactaa gattttagaa ttacctgatt tcgaaaaccc tcatatttat
    13561 gatcagatac aaagagtaac ttcagaatct agttacagac cattccaaat tttcactgag
    13621 attcttaata tattaactaa tattataact ataatttcaa cttcaataat tataattatt
    13681 tggaaatggt gggttgtaat actcttgttt ttaacgccaa tcatatcttc aattttcttt
    13741 gtgaaattag ggaaaaagga atacgaaata gaatgggaaa gaactccatt aagaagaaaa
    13801 atatactatt atattttttt gatgacacgt gattttaata ttaaggaaat aaagcttttt
    13861 aatttaagcg atttattaat tagtagatac gaaaaaatta acaaggtttt tttaaaaaca
    13921 gataaagaaa tggcacaaag aaaaatgaag gtttcgacaa tttttgaaac tgtaaaccaa
    13981 ttaattgttg gtggaataat gttatatatc atattaaaag tattctccaa agaaattatg
    14041 attggaacaa tgatggcctt aatacagggg gttatatctt ctcagacagc tttgaaaacg
    14101 ttaatgcagg gagtattctc tgtttatgaa aacaatttgt atgtaaatga tttctttgaa
    14161 tttgtgaaaa atagaaaatt gaataatgat actaaattgg aggaaaaaat ccaacttacc
    14221 gaaataaata aaattacttt taataatgtt tcatttaaat atccaaataa aaataattat
    14281 gcccttaaaa aaattagttt tgaattaaaa aaaggagaaa caattgcaat tgttggtggt
    14341 aatggctcag gtaagtctac cttaatcaaa cttatatgtc gcttgtatga tggttttgaa
    14401 ggagaaatat taattaactc tatacctatt gaaaaatact caattgagag tattagggct
    14461 cagacaagca ttatttttca ggattttatt aaatatgaat tttcaataag ggaaaatata
    14521 gggtttggta attataatga aatgaagaat caagattttt tggaatatgc agcttacatt
    14581 tctggtgcaa ataagattat aaataagtat ccagacagat ttgacagtca gttggggaag
    14641 atgtttaata aaggacatca actttccggt ggagagtggc aaaaaatggc tatatcgcgt
    14701 gcgatcttta agaaggcaag tttgtatatg atggatgaac caagctctgc cttagacatt
    14761 tactctgaac aagaattatt tataaaatat aatgagtttt taaaaaataa aattggatta
    14821 tttattactc atagatttaa cacagtgcaa ctggcatctc gtattttagt aatgaataat
    14881 ggagaaataa tagagtgtgg cactcataaa gaattgttgc agaataaagg tatgtattat
    14941 gatctgtata atcaacaaaa aaaagtattt tattcaggcc tatgatctga gtagaatatt
    15001 taaaagtaat aagtcgatgg atctgataat tgagacatat tatagttatc taggagctgt
    15061 attatcatgc ttaacaatta tatcgataaa ataataatta agaccagtaa acaaatttct
    15121 gatttacaac tagtcttaaa tttgcaaaga ttagatgata tatcagttgc aagtggaatt
    15181 tcatcagtat gtattttgtt tgctgaatta gattatactt ttccaaatag aggttgggat
    15241 aggataggac atgaatatct aattcatata aaaaaaaaat tagaaggaat ggaagattat
    15301 tcaccgtcat gtctaggagg catgggaggg ataggttttt gtatattagc tttgtcgaaa
    15361 aatggaaata gataccgtaa ttttctaact gattttaatt tatactactt cgatataatt
    15421 aaaaaacata ttgaagaatt taaagacttg tcgagcctac aaaaaaatga tttattcttg
    15481 tatgaaacaa tttatggttt tgctggaata ggaagatact tattgttctt cagggatcag
    15541 agagagtcaa gagatttatt agaaaaaata ttagtattaa ttactcgtat ggctaataaa
    15601 aatgtaaatt cattagcaga tgaaaaatat gtattagact gtgggttggc acatggggta
    15661 agtggaccgc ttagcttact ttctcttagt tacattaata atataattgt tgagggccaa
    15721 ttagatgcga taaagaaaat ttctaatttc cttataaaaa caaaaactaa gagcgctaat
    15781 ggttatttat ttcccaacgg tatcattctt aatgaaaaaa ataaagatca aacagttgat
    15841 ataactacac gagacgcatg gtgttatggt tctccaggaa catgcagggc attgctatta
    15901 gcaaaggaag caacaggtga cgcgaaatat agtaactgtg cggttacagt atttaaagat
    15961 gttataaaaa ggaattttga acagcaaaaa aactattctc ctacattttg tcatggatta
    16021 agtggattat tgacgattac attcttattt aatgaatcaa tcagggatcc taaatttaaa
    16081 tcttatcaaa tatatttagt gaaaaaactt cttggttatt ataatgataa taatgttctt
    16141 ggatttcaaa atatcgaaag ggataatttg aataaggaga ttgttagtga cgagttaggt
    16201 attttgaatg gagtaacagg agtattactg actttacttg catttagaaa ccaaatgacg
    16261 tatacacgtt gggaatcaat tttactgctt aattaaaggt tatttttaac gaaaagattt
    16321 tgcaataaaa atatggttat ggtatagttt tattggaaat gctaacgatt accgaggcaa
    16381 agagtgggga aacccgctct tttgtattga acaggagaat tttgtctcga catgttcatc
    16441 gtttactttt tagcccctgc tcttttgaag cagggttttt atgcagagtg acgagacgaa
    16501 tatgagatcg acagcacaag gaggaagaac atgagcaaaa aagtgactga caccgttcaa
    16561 gaaatggctc agccaatcgt agacagcctt cagctggaac tcgttgacat tgaatttgtc
    16621 aaagagggcc aaagctggtt ccttcgcgtg tttattgatt ccgatgacgg tgtggatatt
    16681 gaggaatgtg ccaaagtaag cgaagcttta agcgaaaagc ttgatgaggc agacccaatc
    16741 agccaaaatt actttcttga agtctcatct ccaggagctg agcgtccgct aaagaaaaaa
    16801 gccgatttcg aaaaatcact aggaaaaaac gtatacatta agacgtatga gcctattgac
    16861 ggcgtaaaag tgtttgaagg tgaactggct gaatttgatg gacaaacagt gacagttgag
    16921 atcacgatca aaacaagaaa gaaacggatc aatattccgt atgaaaagat agctaatgca
    16981 agattagctg ttacattcta atgaatacaa atgttttaag gggggagacc gttaaatgag
    17041 cagtgaatta ttagatgctc tcacgattct tgaaaaagaa aaaggcatca gtaaagaaat
    17101 tatcatcgaa gcaatcgaag ctgcgttaat ttctgcttat aagcggaatt ttaatcaagc
    17161 gcaaaatgta cgggtggatc taaaccgtga aactggctcc atccgtgtat ttgcaagaaa
    17221 agatgtcgtt gacgaagtat acgaccagag attagagatc tcaattgaag aggcacaggg
    17281 catccatccg gaatatatgg tcggcgatgt cgtcgaaatc gaagttacac ctaaggattt
    17341 cgggcgcata gctgctcaaa cagcgaagca ggtcgtcaca cagcgtgtgc gcgaagctga
    17401 gcgcggcgtg atctattctg aatttatcga ccgtgaagaa gacatcatga cagggatcgt
    17461 ccagcgtctg gataataaat ttatctacgt gtctttaggc aaaatagaag ccttgctgcc
    17521 ggttaatgag caaatgccga atgaaagcta caagccccat gaccgcatta aggtatatat
    17581 cacaaaagta gaaaaaacaa cgaagggccc gcagatttat gtgtcaagaa cacatccagg
    17641 cctgttaaag cgtttgtttg aaattgaagt gcctgaaatt tatgatggaa ctgtcgagct
    17701 aaaatctgtt gccagagaag ccggcgaccg ttcgaaaatt tctgttcgca cagatgatcc
    17761 tgacgtggat cctgtcggtt catgcgtagg gcctaaaggc cagcgtgtgc aagcaatcgt
    17821 caatgaatta aaaggtgaaa aaattgacat tgtcaactgg tccagtgatc ctgtagaatt
    17881 tgtcgcgaat gcgctcagcc cttccaaagt gcttgatgtc atcgttaatg aagaagaaaa
    17941 agcgacaact gttattgttc ctgattacca gctgtctctg gcaattggca aaagaggaca
    18001 aaacgcacgc ttagctgcta aactgacagg ctggaagatt gatattaaga gcgaaacgga
    18061 cgcaagagaa cttggaatct atccgagaga acttgaagaa gatgatgagc cgctctttac
    18121 ggagcctgaa actgctgaat cggatgaata agaggtgact ttaggtgaat aaacacaaaa
    18181 agatcccatt acgcaaatgt gtagtgactg gtgaaatgaa gcctaaaaag gaactgatcc
    18241 gagttgtacg gtcaaaagaa ggcgaaatct cagtagaccc gaccggaaaa aagaatgggc
    18301 ggggtgctta tttaacgctg gataaagagt gcatcttagc agcaaaaaag aaaaacactt
    18361 tgcaaaatca atttcaatca caaatcgatg accagatttt cgatgaattg ctggaactgg
    18421 cggaaaaggt gaaaaaataa aatgtctgga atggaatggt ttcccttgct gggtctggcc
    18481 aatcgagctc gtaaggtcgt gtcaggcgaa gacttggtaa taaaagaaat caggaatgcg
    18541 cgtgcaaagc ttgtcctgct tacagaggat gcatcatcta acacagcaaa aaaagtaact
    18601 gacaagtgca attattataa agtcccttat aaaaaagtcg agagtcgcgc ggttcttgga
    18661 cgctctatcg gtaaagaagc ccgtgtcgtt gtcgccgtca ctgaccaagg ttttgcgaat
    18721 aagctgatca gcttgctcga ttaatatttt tgggggtgaa cgaatggcta aaatgagagt
    18781 atacgaatat gcaaaagcgt taaatgtttc aagtaaggaa attttgaccg cactgaagaa
    18841 catggattta gaagtgaata atcacatggc catgcttgaa gaaaaggcca ttaaaaagct
    18901 agatgccaaa tataaaaaag gcggcgcagc tgctaaatct caaaagccag cagaaacgaa
    18961 caaaaacaaa cagccacaag gggttaatca gcaatcagct ggaaatcaac caaataaaat
    19021 tcgagacgga aagaagaatg acgtgcagaa taatcaattt aacaaaaaca agaagaataa
    19081 caacaacaaa aaaaataaac gcaacaacaa caataataaa aaccaacatc agcaaaagcc
    19141 tgtaaagccg aaaaaagagc ttcctgagaa aattacattc tctggcactt taacagttgg
    19201 cgcacttgct gaagagcttg gcaaagagcc ttcagaaatc attaaaaagc tgatgcttct
    19261 tggcgtaatg gcaactatta accaagagct tgataaagac acaatcgaac tcattgcatc
    19321 agaatatggt gttgaaacag aagaggtcat tgtgcttgaa gaaacagagc tggaaaaata
    19381 cgaagagcct gataatgaag aggatcttga aattcgtcct cctgtcgtga caatcatggg
    19441 ccacgttgac catgggaaaa caacgcttct tgacagcatc cgtaaaacaa aggttgttga
    19501 aggagaagca ggcggaatca ctcagcatat cggcgcttat caaattgaag agaacggcaa
    19561 gaaaatcacg tttttggata caccgggcca cgccgcattt acaacaatgc gtgcacgcgg
    19621 tgcagaagta actgatatta cgattcttgt cgtagctgcc gatgacggtg tcatgccgca
    19681 aacagttgaa gcgattaacc atgcaaaagc agcagaggtt ccaatcatcg ttgctgtgaa
    19741 taaaatagat aaagaatccg caaaccctga ccgtgtgatg caagaactga cggaatacgg
    19801 acttgtccct gaagcttggg gcggagaaac catttttgtg ccgctttccg ctttaactgg
    19861 aaaaggcatt gatgagctcg ttgaaatgat tttgcttgtc agtgaggtag aggaactgaa
    19921 agcgaatccg aaccgtcagg caaaaggaac ggttattgaa gctgaactcg ataaaggcag
    19981 agggtcagtt gcgacattgc tcgtacagac tggaacactg catgtcggtg atccgatcgt
    20041 agtcggcaat acatttggcc gtgtccgtgc aatggttaac gacattggcc gccgtgtgaa
    20101 aactgccggc ccgtcaactc cggttgaaat taccggtttg aatgatgtcc ctcaagcggg
    20161 agaccaattc cttgtcttta aggatgaaaa aacagctcgt tctgtcggtg aagcccgtgc
    20221 ttcgaaacag cttgaagagc agcgcagcga taaagcgaag ctcagtcttg atgatttatt
    20281 cgagcaaatt aagcaaggtg atgtaaaaga catcaacctc atcgtaaaag ctgacgttca
    20341 aggatctgct gaagctttaa cggctgcact tcaaaaaatt gaagtagaag gcgttaaagt
    20401 gaaaatcatc catacaggcg ttggtgcgat tactgaatca gacattatct tggcatctgc
    20461 ttccaatgca attgttatcg ggtttaatgt gagaccggac ggaaatgcta agagtacggc
    20521 tgaagctgaa aatgtagata ttcgacttca ccgtatcatt tacaaagtaa tcgacgagat
    20581 cgaagctgcc atgaaaggta tgcttgatcc tgaatatgaa gaaaaagtaa ttggtcaagt
    20641 agaagtacgc caaacattca aagtatctaa aatcggtaca attgccggcg gatatgttac
    20701 tgaaggaacc attacgcgcg acagcggcct ccgtttaatt cgtgacggcg tcgtcatctt
    20761 tgaaggcgaa gtagatgttt tgaaacgctt taaagacgat gtgaaagaag tttcacaagg
    20821 ctatgaatgt ggtattacaa ttaaggaata caatgacatt cgtgaaggtg acatccttga
    20881 agcgtttgtc atgcaagaaa ttgaaagaac gtgatcggat ttgcggagtg tgaatgcatc
    20941 atttatgatg caggatcgct aaaagaaaag cgtgccgttc tgaagcgggt tttaaccagg
    21001 gttcaaaaca agttcaatgt ttcgatttcg gagattggct atcaggacac ctggcaaaga
    21061 accagcttcg gaatcgccgc tgtttcttcc tctcgcgttc aaacagaaaa agaactgcaa
    21121 cgcgtcctag cgtttatcga ttcttttcct gaaattgaac ggacgatcac taggacagag
    21181 tggttttaac ttagaggtga ttgaattgag tatgagagca aaccgtgtcg gcgagcaaat
    21241 gaaaaaagaa ctcggtgata ttatcagccg caagctgaaa gacccgagaa ttggttttct
    21301 gacagtaacg gatgtacgtg tatcaggtga tttgcaaatt gcaaaggtgt atatctcggt
    21361 tctcggtgac gagaaaaaac gggaagaagc gctgaaaggg ctggcaaaag cgaaaggatt
    21421 tatccgatcc gaaatcggca gccgcatcag acttcgaaaa acgcctgaaa ttgaatttga
    21481 gttcgatgaa tcaatcgatt acgggaatcg gatcgaaaca ctgattcacg aattacattc
    21541 agagaaacca tctgaataaa aaatgagagg ataggcgtat atcgtctgtc ctctttcttc
    21601 gtttaaaaga aaaaagctca aaagaaggag tgaaaggcaa atggttaacg gagttctcct
    21661 tttacataaa cctgttggca tgacatcgca cgactgtgtc atgaagatcc gaaagctgtt
    21721 aaaaacaaaa aaagtaggac atacaggaac gctcgatccg gaagtgtcag gcgtgcttcc
    21781 gatttgtgta ggaagagcga caaaaatagt cgaatactta actgaaaaat ctaaaacgta
    21841 tgatgcagaa ataacgcttg gcttttcaac cactacagag gatcaaaccg gagaaacggt
    21901 ggaagcaaag cctgtcaatc acgacattga taaagcggat gtagaaaagg ttttaaacag
    21961 tttaaaggga aaacaagaac aaattccgcc catgtattcc gctgtaaaag taaacggcaa
    22021 aaaattatac gaatacgcaa gagcagggat tgaagtagaa cgtccgaaac gtatgataac
    22081 cattgaagac attgccctga cgacagagat taaacatcat ggagaaaccg caagcttccg
    22141 gtttacagtg acttgctcca aagggaccta tgtaaggacg ctggcggtca tgatcggaga
    22201 aaagctcgga tatccggctc atatgtctca tttaatccgt acggcatccg gagatttttc
    22261 tctcgacgaa tgctttactt ttgatgagct cgaagcacag gcccaatccg gaaccgtgga
    22321 agaacataca gttcctattg aacgtgcgct caatcatttg ccgaaatgga tcataagtga
    22381 tacattagct aagaaagtag aaaatggggc tttgcttgag acgcccgagc agttttctga
    22441 aatgacaagt gaagaccgta tcgctgtctt tactgaatcc ggaacctgtt tggcgatcta
    22501 tttccctcat cctgcaaaaa aagggctgtt aaagccggca aaagtattga tgcaaaaaag
    22561 cgaacaatag aaaaaaggtg accgttctgt gaagacgata catattacac atcctcatca
    22621 tttaataaaa gaggagcagg caaaatcagt gatggcgtta ggatattttg acggcgttca
    22681 tctcgggcat caaaaggtaa tcggcacagc gaagcaaata gccgaagaaa aaggtctgac
    22741 attggctgtg atgacctttc atccccatcc ttctcacgtg ttgggcagag ataaggaacc
    22801 taaggatctg attacgcctc ttgaagacaa aataaatcaa attgaacaat taggtacaga
    22861 agttctgtat gtcgttaaat ttaatgaagt gtttgcttct ctttctccta agcagtttat
    22921 agaccagtat attatcggcc ttaatgtaca gcacgcagtg gcaggctttg actttacgta
    22981 cggcaaatac ggcaagggaa caatggagac catgccggat gatttagacg gaaaagctgg
    23041 gtgcacaatg gtagaaaaat tgacggagca ggataaaaaa atcagttctt cgtatatccg
    23101 taccgcgctt caaaacggag atgttgaatt ggcgaatgtc ttgcttggac agccatattt
    23161 tattaaagga attgtcattc atggtgataa aagagggcgg accatcggtt ttccgacagc
    23221 gaatgtcggt ttaaataaca gctatatcgt tccgcccaca ggtgtatatg ccgtaaaagc
    23281 ggaagtgaac ggcgaagttt acaatggcgt ttgcaatatt ggctataagc cgacgtttta
    23341 tgaaaagcgc cctgagcagc cttccatcga ggtcaatctg tttgatttcg atcaagaggt
    23401 atatggagcc gctataaaaa tcgaatggta caaacggatt cggagcgagc ggaaattcaa
    23461 tggcatcaaa gaattaacag agcaaattga gaaagataag caggaagcca tccgttattt
    23521 cagcaatttg cggaaataac ttgcaacgca cgcaaatttt attctaaaat atttgcatat
    23581 aggcgcgatt tttagtatga tagttttcgt agtcttaaaa ccattgcttg gcaatccgaa
    23641 gtcaccgacg gttgctaggt aactggggct aaatatgatt tggaggtgaa acaggatggc
    23701 aattactcaa gagcgtaaaa accaactcat caatgagttc aaaacacacg aatctgatac
    23761 tggatctcca gaagttcaga tcgctatcct aactgactca attaacaact tgaacgagca
    23821 tttacgtact cacaagaaag accaccactc acgtcgcggt cttcttaaaa tggtaggtaa
    23881 gcgtcgtaat cttcttacgt atctgcgtaa taaagacgta actcgttacc gtgagttaat
    23941 taacaaacta ggcttacgtc gataatcgta aaaagcggga ggattcccgc ttttttatcg
    24001 tattaaagcg aaatttctta taacaaatca ttgaaatcct tttacatact actttgacat
    24061 tgatatgttc aattcatttc gttcataata ggagtaattg attatttcac acaacgaaga
    24121 gaggagttcg taattgtatg ggacaagaaa aacatgtctt taccatagat tgggccggaa
    24181 gaacgcttac tgttgaaacc ggccagcttg ccaaacaggc aaatggtgct gtgatgatcc
    24241 gctacggtga tacagcagta cttagtacag caaccgcttc aaaagaacct aaaccgcttg
    24301 atttcttccc tcttactgta aactatgaag aaagattata tgcggtaggg aaaattccgg
    24361 gcggatttat taaaagagaa ggacgtccaa gtgaaaaagc ggttcttgcc agccgtttaa
    24421 ttgaccgtcc gatccgtcct ttgtttgccg atggattccg taatgaagtt caagtcatca
    24481 gcattgtcat gagtgttgac caaaactgct cttcagaaat ggctgccatg ttcggttcat
    24541 ctcttgcgct ttctgtatcg gatattccgt ttgaaggacc gattgcaggg gttactgtcg
    24601 gacgcattaa tgatcaattt atcattaacc cgacagtcga tcagcttgaa aaaagcgaca
    24661 tcaatcttgt cgttgccggc acgaaagatg cgattaacat ggtagaagcg ggtgcggacg
    24721 aagttcctga ggaaatcatg cttgaggcca ttatgttcgg ccatgaagag attaaacgcc
    24781 tgattgcatt ccaagaagaa attgttgcag cggtcggcaa agagaaatct gaaattaagc
    24841 tctttgaaat tgatgaagag cttaatgaaa aagtaaaagc tttggcagaa gaggatctgc
    24901 tgaaagccat ccaagttcat gaaaagcatg cccgtgaaga tgccattaac gaagtgaaga
    24961 acgcagttgt ggcaaaattc gaggatgaag aacatgatga agacacaatc aagcaagtga
    25021 agcagatttt atccaagctg gtgaaaaatg aagttcgccg cctgattact gaagagaaag
    25081 taagaccgga cggccgcggt gtcgatcaaa tccgcccgct ctcttcagag gttggccttt
    25141 tgccaagaac gcacggttca ggtctattta caagaggaca aactcaggcc ctcagcgtat
    25201 gtacgctagg tgctctggga gatgtgcaaa tccttgacgg cttaggtgtc gaagagtcga
    25261 aacggtttat gcatcattac aatttcccgc aattcagcgt tggggaaaca ggaccgatgc
    25321 gcggaccggg acgtcgtgaa atcggacacg gagcactggg tgagcgtgcg cttgagccag
    25381 ttattccgtc tgaaaaagac ttcccttata ctgtccgtct tgtttcagaa gtgcttgaat
    25441 caaacggttc tacatctcaa gcaagcattt gcgcaagcac acttgcaatg atggatgctg
    25501 gtgtaccgat taaagcgcca gttgctggta ttgcgatggg tcttgtcaaa tcaggcgaac
    25561 attacactgt cttgactgac atccaaggca tggaagacgc gctcggagat atggacttta
    25621 aagtagcggg aaccgaaaaa ggcgtaacgg ccctgcaaat ggacattaaa attgaaggcc
    25681 tttccagaga gattcttgaa gaagcgcttc agcaggcgaa aaagggcaga atggaaatcc
    25741 tcaacagcat gcttgcaaca ttaagcgaat caagaaaaga gctttctcga tatgcgccta
    25801 agatcttaac aatgaccatt aatcctgata aaatccgcga tgtcatcgga ccaagcggaa
    25861 aacaaatcaa taagatcatc gaagaaaccg gtgttaaaat tgatattgag caggacggca
    25921 caatctttat ttcctctaca gatgaaagcg gcaaccaaaa agcgaaaaaa atcatcgaag
    25981 accttgttag agaggttgaa gtcggccaac tttacctagg taaagtgaaa cggattgaaa
    26041 aattcggggc tttcgttgaa attttcagcg gaaaagacgg tttggtgcac atttcggagc
    26101 ttgcgcttga acgagtaggg aaagttgaag atgttgtaaa aatcggagac gagattcttg
    26161 tcaaagtcac tgaaattgat aaacaaggac gagtgaattt atcccgcaaa gcggtgctcc
    26221 gtgaagagaa agaaaaagaa gaacaacaat cttaaatgaa aacataaaag gagcctggga
    26281 gacccggctt ctttat
//
