Select genomic region:
Overview
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8
1.9
1.10
1.11

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP089148.1 (Bacillus subtilis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | NRPS | 391,971 | 457,362 | High | surfactin | NRPS:Type I
Region 1.2 | lanthipeptide-class-i | 1,770,340 | 1,796,635 |
Region 1.3 | NRPS,betalactone | 1,929,526 | 1,981,070 | High | fengycin | NRPS:Type I
Region 1.4 | terpene | 2,058,662 | 2,080,560 |
Region 1.5 | T3PKS | 2,259,097 | 2,300,194 | Low | 1-carbapen-2-em-3-carboxylic acid | other:other
Region 1.6 | terpene-precursor | 2,479,988 | 2,500,878 |
Region 1.7 | terpene-precursor,NRP-metallophore,NRPS | 3,251,141 | 3,317,594 | High | bacillibactin | NRPS:Type I
Region 1.8 | lanthipeptide-class-i | 3,463,829 | 3,490,054 | High | subtilin | ribosomal:RiPP:Lanthipeptide
Region 1.9 | sactipeptide | 3,851,113 | 3,872,724 | High | subtilosin A | ribosomal:RiPP:Thiopeptide
Region 1.10 | other | 3,876,027 | 3,917,445 | High | bacilysin | other:other
Region 1.11 | epipeptide | 4,144,821 | 4,166,519 |  |

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | NRPS | 391,971 | 457,362 | High | surfactin | NRPS:Type I
Region 1.2 | lanthipeptide-class-i | 1,770,340 | 1,796,635 |
Region 1.3 | NRPS,betalactone | 1,929,526 | 1,981,070 | High | fengycin | NRPS:Type I
Region 1.4 | terpene | 2,058,662 | 2,080,560 |
Region 1.5 | T3PKS | 2,259,097 | 2,300,194 | Low | 1-carbapen-2-em-3-carboxylic acid | other:other
Region 1.6 | terpene-precursor | 2,479,988 | 2,500,878 |
Region 1.7 | terpene-precursor,NRP-metallophore,NRPS | 3,251,141 | 3,317,594 | High | bacillibactin | NRPS:Type I
Region 1.8 | lanthipeptide-class-i | 3,463,829 | 3,490,054 | High | subtilin | ribosomal:RiPP:Lanthipeptide
Region 1.9 | sactipeptide | 3,851,113 | 3,872,724 | High | subtilosin A | ribosomal:RiPP:Thiopeptide
Region 1.10 | other | 3,876,027 | 3,917,445 | High | bacilysin | other:other
Region 1.11 | epipeptide | 4,144,821 | 4,166,519 |  |

No secondary metabolite regions were found in these records:
  NZ_CP089149.1 (Bacillus subtilis)
  NZ_CP089150.1 (Bacillus subtilis)
  NZ_CP089151.1 (Bacillus subtilis)
  NZ_CP089152.1 (Bacillus subtilis)
  NZ_CP089153.1 (Bacillus subtilis)

Compact view
NZ_CP089148.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 391,971 - 457,362 nt. (total: 65,392 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
LRO88_RS02145: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: PPTase acyltransferase aminotransferase
LRO88_RS02265: polyketide synthase associated protein papA3

smcogs
  SMCOG1209: polyketide synthase associated protein papA3

LRO88_RS02300: aminotransferase

smcogs
  SMCOG1019: aminotransferase

LRO88_RS02305: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: dehalogenase esterase
LRO88_RS02280: thioesterase

smcogs
  SMCOG1004: thioesterase

LRO88_RS02355: haloalkane dehalogenase

smcogs
  SMCOG1262: haloalkane dehalogenase

Ligases: ligase synthase
LRO88_RS02170: cobalamin synthesis protein/P47K family protein

smcogs
  SMCOG1178: cobalamin synthesis protein/P47K family protein

LRO88_RS02250: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

LRO88_RS02255: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

LRO88_RS02270: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

LRO88_RS02275: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001833.4 |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  | 0.75 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.74 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0002075.3 |  | 0.73 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0002286.3 |  | 0.73 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  | 0.73 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001135.5 |  | 0.73 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001825.4 |  | 0.72 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001758.4 |  | 0.72 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0000433.5 |  | 0.71 | NRPS | surfactin | Bacillus velezensis FZB42

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001833.4 |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  | 0.75 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.74 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0002075.3 |  | 0.73 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0002286.3 |  | 0.73 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  | 0.73 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001135.5 |  | 0.73 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001825.4 |  | 0.72 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001758.4 |  | 0.72 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0000433.5 |  | 0.71 | NRPS | surfactin | Bacillus velezensis FZB42

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.65 out of 18.46
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.77 out of 27.55
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.09 out of 30.25
Confidence: medium
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.16 out of 26.33
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.38 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.04 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.42 out of 27.78
Confidence: medium
Additional weak hits (9):
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.63 out of 26.12
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.59 out of 39.62
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.98 out of 28.14
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.50 out of 26.12
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.77 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.96 out of 26.06
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.22 out of 28.14
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.18 out of 29.25
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.39 out of 33.14
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 391970 - 457362:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Glu - Leu - D-Leu) + (Val) + (Asp - D-Leu) + (Leu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
LRO88_RS02250: Glu - Leu - Leu
Search NORINE for peptide: strict or relaxed
AMP-binding (466..867): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    gln (Gln)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSLAFDASVKQADGLIGGETNVYGPTETCVDASV
  Nearest Stachelhaus code(s):
    Glu DAKDLGVVDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1510..1908): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TETSFDAFMFDGMIMFGGELHMYGPSESTVFATY
  Nearest Stachelhaus code(s):
    Leu DAFMMGMVFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (2550..2938): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWHAFDASIWEPFLLTGGDVNNYGPTENTVVATS
  Nearest Stachelhaus code(s):
    Leu DAWFLGNVVK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

LRO88_RS02255: Val
Search NORINE for peptide: strict or relaxed
AMP-binding (470..864): Val
nrpys: Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    val (Val)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNAGFDAGTFEGWLIIGGDWNGYGPTENTTFSTS
  Nearest Stachelhaus code(s):
    Val DAFWIGGTFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

LRO88_RS02265: Asp - Leu
Search NORINE for peptide: strict or relaxed
AMP-binding (427..830): Asp
nrpys: Asp

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asp (Asp)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWFSFDLGYTSPKLVLGGEINHYGPTEATIGAIA
  Nearest Stachelhaus code(s):
    Asp DLTKVGHIGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1472..1860): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWHAFDASIWEPFLLTGGDVNNYGPTENTVVATS
  Nearest Stachelhaus code(s):
    Leu DAWFLGNVVK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

LRO88_RS02275: Leu
Search NORINE for peptide: strict or relaxed
AMP-binding (469..867): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LHVSFDAFTFDAFALFGGEINCYGPTEGTVFATA
  Nearest Stachelhaus code(s):
    Leu DAFFLGCVFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
GnfM | Regulator of nitrogen-fixation genes
MogR | Repressor of flagellar motility genes
RpoN | Regulator of nitrogen assimilation and virulence
ToxT | Regulator of MSHA biosynthesis

NZ_CP089148.1 - Region 2 - lanthipeptide-class-i
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,770,340 - 1,796,635 nt. (total: 26,296 nt) Show pHMM detection rules used
lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: back translocase
LRO88_RS09450: GTP-binding protein LepA

smcogs
  SMCOG1190: GTP-binding protein LepA

Lyases: cyclase dehydratase
LRO88_RS09415: Lantibiotic dehydratase domain protein

smcogs
  SMCOG1155: Lantibiotic dehydratase domain protein

LRO88_RS09425: Lanthionine synthetase C family protein

smcogs
  SMCOG1140: Lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-i | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002576.2 |  | 0.75 | ribosomal | mechercharmycin | Thermoactinomyces sp.
BGC0000541.5 |  | 0.57 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0001289.5 |  | 0.57 | ribosomal | penisin | Paenibacillus ehimensis
BGC0000538.3 |  | 0.55 | ribosomal | nisin Z | Lactococcus lactis
BGC0000542.3 |  | 0.54 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0000507.5 |  | 0.51 | ribosomal | epicidin | Staphylococcus epidermidis
BGC0000515.4 |  | 0.50 | ribosomal | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0000506.4 |  | 0.49 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii
BGC0001789.3 |  | 0.48 | ribosomal | suicin 90-1330 | Streptococcus suis
BGC0000537.3 |  | 0.48 | ribosomal | nisin U | Streptococcus uberis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002576.2 |  | 0.75 | ribosomal | mechercharmycin | Thermoactinomyces sp.
BGC0000541.5 |  | 0.57 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0001289.5 |  | 0.57 | ribosomal | penisin | Paenibacillus ehimensis
BGC0000538.3 |  | 0.55 | ribosomal | nisin Z | Lactococcus lactis
BGC0000542.3 |  | 0.54 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0000507.5 |  | 0.51 | ribosomal | epicidin | Staphylococcus epidermidis
BGC0000515.4 |  | 0.50 | ribosomal | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0000506.4 |  | 0.49 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii
BGC0001789.3 |  | 0.48 | ribosomal | suicin 90-1330 | Streptococcus suis
BGC0000537.3 |  | 0.48 | ribosomal | nisin U | Streptococcus uberis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for LRO88_RS09415

LRO88_RS09410
Leader:
MEKDIFDLDLKIQTSKSNVEPN
Core:
S I R L T F G C S G G V A S K A L C S R A M C D G I V I T K N Y G Y C D A
Core with dehydrations:
Dha I R L Dhb F G Cys Dha G G V A Dha K A L Cys Dha R A M Cys D G I V I Dhb K N Y G Y Cys D A

#### antiSMASH-DB 4.0 matches for LRO88_RS09410

100.0%
NZ_CP021903.1 and 6 others:
NZ_CP023409.1 Lanthipeptides: Bateq7PJ16_RS09270_lanthipeptide NZ_CP028218.1 Lanthipeptides: C7M30_RS01850_lanthipeptide NZ_CP035167.1 Lanthipeptides: EQJ08_RS08875_lanthipeptide NZ_CP089148.1 Lanthipeptides: LRO88_RS09410_lanthipeptide NZ_JAMYDW010000001.1 Lanthipeptides: NHM07_RS00470_lanthipeptide NZ_JAQOXM010000003.1 Lanthipeptides: PO770_RS15540_lanthipeptide
Lanthipeptides: CD007_RS08815_lanthipeptide
1
S I R L T F G C S G G V A S K A L C S R A M C D G I V I T K N Y G Y C D A
37
S I R L T F G C S G G V A S K A L C S R A M C D G I V I T K N Y G Y C D A
1
S I R L T F G C S G G V A S K A L C S R A M C D G I V I T K N Y G Y C D A
37
94.6%
NZ_JAJQVT010000008.1:
Lanthipeptides: PAF28_RS14660_lanthipeptide
1
S I R L T F G C S G G V A S K A L C S R A M C D G I V I T K N Y G Y C D A
37
S I R L T F G C+G G V A S K A L C S R A M C D G I V I T K N Y G Y C+A
1
S I R L T F G C T G G V A S K A L C S R A M C D G I V I T K N Y G Y C E A
37
24.3%
NZ_JAASAG010000001.1:
Lanthipeptides: allorf_344422_344553_lanthipeptide
9
S G G V A S K A L C S R A M C D G I
26
+G G K A C R A C I
1
A G G P V R K A G C Q R A G C K R I
18
with 5 more sequence matches
21.6%
NZ_KZ857173.1:
Lanthipeptides: allorf_741535_741753_lanthipeptide
1
S I R L T F G C S G G V A
13
I R L T G C S G++
11
Q I R L T T G C S T G L S
23
16.2%
NZ_PVRU01000017.1 and 3 others:
NZ_PVRU01000017.1 Lanthipeptides: C6360_RS28255_lanthipeptide NZ_PVRU01000017.1 Lanthipeptides: C6360_RS28260_lanthipeptide NZ_PVRU01000017.1 Lanthipeptides: C6360_RS28255_lanthipeptide
Lanthipeptides: C6360_RS28260_lanthipeptide
12
V A S K A L C S R A M C D G I V I T K N Y
32
+ S L C+ + I ++K+Y
14
I T S T V L C A N G L T I S I A V S K S Y
34
13.5%
NZ_BNCE01000001.1:
Lanthipeptides: IE320_RS02935_lanthipeptide
10
G G V A S K A L C S R A M C D
24
G+A++ +C+R C
3
S G I A T R T I C T R V T C Q
17
13.3%
NZ_CP009280.1 and 1 other:
NZ_CP009280.1 Lanthipeptides: allorf_0384816_0385007_lanthipeptide
Lanthipeptides: allorf_0384816_0385007_lanthipeptide
22
M C D G I V I T K N Y G
33
+C D I+ N Y G
33
V C D K I L F P H N Y G
44
11.6%
NZ_JALGBX010000020.1 and 1 other:
NZ_JANAVF010000016.1 Lanthipeptides: NLX94_RS30150_lanthipeptide
Lanthipeptides: MTF69_RS28785_lanthipeptide
11
G V A S K A L C S R A M C D G
25
G+A++ +C+R C
11
G I A T R T V C T R V T C Q A
25

#### MIBiG 4.0 matches for LRO88_RS09410

10.8%
BGC0000503.5 (cinA):
Lanthipeptide: cinnamycin
4
L T F G C S G G V
12
T F C G
10
F T F V C D G N T
18
10.8%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
5
T F G C S G G
11
T G C G
8
T P G C K T G
14

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.97 out of 21.55
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.31 out of 26.06
Confidence: medium
Additional weak hits (1):
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.81 out of 23.43
Confidence: weak
Lanthipeptides
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

LRO88_RS09410 - Class I
  Cleavage pHMM score: 13.90
  RODEO score: 23
  Monoisotopic mass: 3721.8 Da
  Molecular weight: 3724.3 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3742.3 Da N = 1
    3760.4 Da N = 2

RRE predictions
RREfinder results sidepanel.

lanthipeptide-class-i protocluster (1770339...1796635)
LRO88_RS09415
  RRE type: Lanthipeptide_LanB_RRE
  Location: 166 - 258
  Score: 28.5

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis

NZ_CP089148.1 - Region 3 - NRPS,betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,929,526 - 1,981,070 nt. (total: 51,545 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
LRO88_RS10305: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

Transferases: carboxylase transferase
LRO88_RS10260: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs
  SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

LRO88_RS10275: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

LRO88_RS10295: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Hydrolases: peptidase
LRO88_RS10375: gamma-glutamyltranspeptidase

smcogs
  SMCOG1274: gamma-glutamyltranspeptidase

Lyases: hydratase
LRO88_RS10280: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase
LRO88_RS10285: 2-isopropylmalate synthase

smcogs
  SMCOG1271: 2-isopropylmalate synthase

LRO88_RS10300: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

LRO88_RS10330: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

LRO88_RS10335: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000426.5 |  |  | 0.79 | NRPS | sevadicin | Paenibacillus larvae
BGC0001132.4 |  |  | 0.75 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  |  | 0.74 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0002286.3 |  |  | 0.72 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  |  | 0.72 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000342.4 |  |  | 0.71 | NRPS | enniatin | Fusarium equiseti
BGC0001133.4 |  |  | 0.71 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0002135.2 |  |  | 0.69 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001758.4 |  |  | 0.69 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000426.5 |  | 0.71 | NRPS | sevadicin | Paenibacillus larvae
BGC0001132.4 |  | 0.70 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.70 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  | 0.70 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0002286.3 |  | 0.69 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.69 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000342.4 |  | 0.68 | NRPS | enniatin | Fusarium equiseti
BGC0001133.4 |  | 0.68 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0002135.2 |  | 0.68 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001758.4 |  | 0.68 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.53 out of 20.97
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.60 out of 21.55
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.00 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.64 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.34 out of 26.06
Confidence: medium
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.80 out of 26.33
Confidence: medium
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.93 out of 29.25
Confidence: medium
Additional weak hits (6):
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.44 out of 20.47
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.47 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.22 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.11 out of 26.06
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.85 out of 31.73
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.65 out of 29.65
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 3, location 1929525 - >1981070:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Glu - D-Tyr) + (Ile)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
LRO88_RS10300: X
AMP-binding (13..445): X
nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    NNIVF-GCVLGAHGIMAGSTIAYGQTEASPVITQ
  Nearest Stachelhaus code(s):
    Z-ahmohOrn FGLHIASTCK (56% 8Å match)
    Ile DGLFIGIPVK (32% 8Å match)
  Stachelhaus code match:
    60% (weak)

LRO88_RS10330: Ile
Search NORINE for peptide: strict or relaxed
AMP-binding (481..874): Ile
nrpys: Ile

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    ile (Ile)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNSGFDAVTFEGFLYVGGEHNIYGPTENTTFSTF
  Nearest Stachelhaus code(s):
    Ile DAFFYGITFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

LRO88_RS10335: Glu - Tyr
Search NORINE for peptide: strict or relaxed
AMP-binding (461..862): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    glu (Glu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FGMTFDASVWQWHFFAGGEIHGYGPTEATVDAAF
  Nearest Stachelhaus code(s):
    Glu DAWHFGGVDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1500..1894): Tyr
nrpys: Tyr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Polar aromatic ring (Tyr, bOH-Tyr)
  Single AA prediction:
    tyr (Tyr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TWRFFDGFLTSTIITLAGEANEYGPTENSVATTV
  Nearest Stachelhaus code(s):
    Tyr DGTITAEVAK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
ArcA | Repressor of carbon oxidation
CcpA | Catabolite control protein A
MogR | Repressor of flagellar motility genes
SypG | Regulator of biofilm formation and host colonization
ToxT | Regulator of MSHA biosynthesis

NZ_CP089148.1 - Region 4 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,058,662 - 2,080,560 nt. (total: 21,899 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
LRO88_RS10980: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000313.4 |  | 0.36 | NRPS | beauvericin | Beauveria bassiana
BGC0001535.3 |  | 0.34 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0002255.3 |  | 0.29 | PKS | lijiquinone | Ascomycota sp. F53
BGC0000663.5 |  | 0.27 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0001338.4 |  | 0.26 | PKS | citrinin | Monascus ruber
BGC0001575.4 |  | 0.26 | NRPS | PZN5, PZN6, PZN7, PZN9, PZN10, PZN11 | Ruminococcus sp. 5_1_39BFAA
BGC0000154.4 |  | 0.26 | PKS | stipitatic acid | Talaromyces stipitatus ATCC 10500
BGC0001739.3 |  | 0.25 | other (other) | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0002246.3 |  | 0.24 | terpene | naematolin | Hypholoma sublateritium FD-334 SS-4
BGC0001057.4 |  | 0.24 | NRPS, PKS | zearalenone | Fusarium graminearum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000313.4 |  | 0.36 | NRPS | beauvericin | Beauveria bassiana
BGC0001535.3 |  | 0.34 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0002255.3 |  | 0.29 | PKS | lijiquinone | Ascomycota sp. F53
BGC0000663.5 |  | 0.27 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0001338.4 |  | 0.26 | PKS | citrinin | Monascus ruber
BGC0001575.4 |  | 0.26 | NRPS | PZN5, PZN6, PZN7, PZN9, PZN10, PZN11 | Ruminococcus sp. 5_1_39BFAA
BGC0000154.4 |  | 0.26 | PKS | stipitatic acid | Talaromyces stipitatus ATCC 10500
BGC0001739.3 |  | 0.25 | other (other) | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0002246.3 |  | 0.24 | terpene | naematolin | Hypholoma sublateritium FD-334 SS-4
BGC0001057.4 |  | 0.24 | NRPS, PKS | zearalenone | Fusarium graminearum

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | hopanoid |  | C30 | hopanoid skeleton | unknown
triterpene | polypodane |  | C30 | polypodane skeleton | unknown

Genes with terpene domains:
LRO88_RS10985: T2TS
Domain 1 (4 - 629): Type 2 terpene synthase
Subtype: Squalene substrate

Reactions:
  squalene → hopanoid
  squalene → polypodane

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 25.99 out of 33.73
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 26.30 out of 27.78
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.78 out of 20.97
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.34 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.70 out of 26.06
Confidence: medium
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 20.10 out of 21.84
Confidence: medium
Additional weak hits (5):
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.62 out of 21.55
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.49 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.69 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.69 out of 26.06
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.
No acronyms to display
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
HipB | Bacterial antitoxin HipB
MexT | Global virulence regulator
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis

NZ_CP089148.1 - Region 5 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,259,097 - 2,300,194 nt. (total: 41,098 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
LRO88_RS12430: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: kinase methyltransferase
LRO88_RS12380: isoprenylcysteine carboxyl methyltransferase

smcogs
  SMCOG1150: isoprenylcysteine carboxyl methyltransferase

LRO88_RS12415: PfkB domain protein

smcogs
  SMCOG1276: PfkB domain protein

Ligases: synthase
LRO88_RS12385: chalcone and stilbene synthase domain protein

smcogs
  SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001831.3 |  | 0.51 | PKS | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0000282.3 |  | 0.49 | PKS | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001962.3 |  | 0.45 | PKS | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0001847.2 |  | 0.44 | other (other) | 1-carbapen-2-em-3-carboxylic acid | Pectobacterium carotovorum
BGC0001475.4 |  | 0.43 | terpene | aspterric acid | Aspergillus terreus NIH2624
BGC0002332.2 |  | 0.42 | PKS | 4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A | Candidatus Entotheonella sp.
BGC0001928.2 |  | 0.40 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0001605.3 |  | 0.39 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000509.4 |  | 0.36 | ribosomal | epilancin 15x | Staphylococcus epidermidis
BGC0001882.3 |  | 0.36 | PKS | chrysoxanthone A, chrysoxanthone B, chrysoxanthone C | Penicillium rubens Wisconsin 54-1255

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001831.3 |  | 0.51 | PKS | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0000282.3 |  | 0.49 | PKS | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001962.3 |  | 0.45 | PKS | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0001847.2 |  | 0.44 | other (other) | 1-carbapen-2-em-3-carboxylic acid | Pectobacterium carotovorum
BGC0001475.4 |  | 0.43 | terpene | aspterric acid | Aspergillus terreus NIH2624
BGC0002332.2 |  | 0.42 | PKS | 4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A | Candidatus Entotheonella sp.
BGC0001928.2 |  | 0.40 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0001605.3 |  | 0.39 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000509.4 |  | 0.36 | ribosomal | epilancin 15x | Staphylococcus epidermidis
BGC0001882.3 |  | 0.36 | PKS | chrysoxanthone A, chrysoxanthone B, chrysoxanthone C | Penicillium rubens Wisconsin 54-1255

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.48 out of 23.79
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 27.65 out of 32.74
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.84 out of 29.38
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.14 out of 28.19
Confidence: medium
Additional weak hits (7):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.59 out of 26.06
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.03 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.46 out of 32.74
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.76 out of 32.74
Confidence: weak
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.38 out of 29.72
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.18 out of 25.75
Confidence: weak
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.01 out of 24.78
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
FuR variant 1 | Ferric Uptake Regulator
FuR variant 2 | Ferric Uptake Regulator
IolR | Regulator of the inositol catabolism
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_CP089148.1 - Region 6 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,479,988 - 2,500,878 nt. (total: 20,891 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
LRO88_RS13535: NADH:flavin oxidoreductase/NADH oxidase

smcogs
  SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

Transferases: carboxylase
LRO88_RS13600: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase
LRO88_RS13565: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

LRO88_RS13570: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0000895.5 |  | 0.41 | other (other) | citrulline | Lactobacillus plantarum subsp. plantarum
BGC0002284.3 |  | 0.40 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000234.5 |  | 0.38 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0001605.3 |  | 0.38 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000639.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC260

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0000895.5 |  | 0.41 | other (other) | citrulline | Lactobacillus plantarum subsp. plantarum
BGC0002284.3 |  | 0.40 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000234.5 |  | 0.38 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0001605.3 |  | 0.38 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000639.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC260

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
LRO88_RS13570: PT_FPPS_like
Domain 1 (33 - 296): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  IPP, DMAPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (3):
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.20 out of 25.88
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 20.50 out of 30.12
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.21 out of 30.11
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---

NZ_CP089148.1 - Region 7 - NRP-metallophore,NRPS,terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,251,141 - 3,317,594 nt. (total: 66,454 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase reductase
LRO88_RS18035: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

LRO88_RS18110: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

LRO88_RS18160: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

LRO88_RS18165: alkyl hydroperoxide reductase subunit

smcogs
  SMCOG1176: alkyl hydroperoxide reductase subunit

LRO88_RS18210: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Hydrolases: esterase hydrolase
LRO88_RS17945: thioesterase superfamily protein

smcogs
  SMCOG1144: thioesterase superfamily protein

LRO88_RS17995: isochorismatase

smcogs
  SMCOG1027: isochorismatase

LRO88_RS18095: isochorismatase

smcogs
  SMCOG1027: isochorismatase

Isomerases: isomerase
LRO88_RS18105: isochorismate synthase

smcogs
  SMCOG1018: isochorismate synthase

Ligases: ligase synthetase
LRO88_RS17965: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

LRO88_RS18090: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

LRO88_RS18100: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | NRP-metallophore | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | ---
BGC0000309.5 |  |  |  | 1.62 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0001185.5 |  |  |  | 1.10 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000401.5 |  |  |  | 1.05 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0002075.3 |  |  |  | 0.87 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001132.4 |  |  |  | 0.76 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  |  |  | 0.76 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  |  |  | 0.75 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  |  |  | 0.75 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0002286.3 |  |  |  | 0.73 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  |  |  | 0.73 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000309.5 |  | 0.93 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0001185.5 |  | 0.82 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000401.5 |  | 0.80 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0002075.3 |  | 0.74 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001132.4 |  | 0.70 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.70 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  | 0.70 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  | 0.70 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0002286.3 |  | 0.69 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.69 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
LRO88_RS17965: PT_FPPS_like
Domain 1 (44 - 285): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.03 out of 26.06
Confidence: medium
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 21.85 out of 25.31
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.61 out of 29.38
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.03 out of 30.25
Confidence: medium
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.64 out of 32.74
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.49 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.93 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.36 out of 29.38
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.52 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.97 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.08 out of 26.06
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.87 out of 18.16
Confidence: strong
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.24 out of 18.16
Confidence: strong
Additional weak hits (17):
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.98 out of 29.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.45 out of 26.06
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.33 out of 29.25
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.61 out of 32.74
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.12 out of 29.38
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.39 out of 28.14
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.69 out of 29.38
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.84 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.85 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.19 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.15 out of 26.06
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.11 out of 33.14
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.01 out of 35.63
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
Terpene
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 7, location 3251140 - 3317594:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 9, location 3265816 - 3317594:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
LRO88_RS18090: Gly - Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (463..861): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSMTFDISALELQALVGGETNLYGPTETTIWSAA
  Nearest Stachelhaus code(s):
    Gly DILQLGLIWK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1519..1935): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LATHFDFSVWEGNQIFGGEINMYGITETTVHVSY
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

LRO88_RS18100: diOH-Bz
Search NORINE for peptide: strict or relaxed
AMP-binding (31..435): diOH-Bz
nrpys: diOH-Bz

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Small clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Single AA prediction:
    dhb (diOH-Bz)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SRSLYPLSSPGGALQVGGAQQVFGMAEGLVNYTR
  Nearest Stachelhaus code(s):
    diOH-Bz PLPAQGVVNK (100% 8Å match)
    diOH-Bz or Sal PLPAQGVVNK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CatR | H2O2-responsive repressor
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
FuR variant 1 | Ferric Uptake Regulator
FuR variant 2 | Ferric Uptake Regulator
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_CP089148.1 - Region 8 - lanthipeptide-class-i
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,463,829 - 3,490,054 nt. (total: 26,226 nt) Show pHMM detection rules used
lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: dehalogenase
LRO88_RS18995: haloalkane dehalogenase

smcogs
  SMCOG1262: haloalkane dehalogenase

Lyases: cyclase dehydratase
LRO88_RS19060: Lanthionine synthetase C family protein

smcogs
  SMCOG1140: Lanthionine synthetase C family protein

LRO88_RS19070: Lantibiotic dehydratase domain protein

smcogs
  SMCOG1155: Lantibiotic dehydratase domain protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-i | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000506.4 |  | 0.89 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii
BGC0000559.4 |  | 0.88 | ribosomal | subtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0002576.2 |  | 0.75 | ribosomal | mechercharmycin | Thermoactinomyces sp.
BGC0000511.5 |  | 0.70 | ribosomal | ericin S | Bacillus subtilis
BGC0000538.3 |  | 0.64 | ribosomal | nisin Z | Lactococcus lactis
BGC0000542.3 |  | 0.60 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0000541.5 |  | 0.60 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0001289.5 |  | 0.59 | ribosomal | penisin | Paenibacillus ehimensis
BGC0000556.5 |  | 0.59 | ribosomal | streptin | Streptococcus pyogenes
BGC0000537.3 |  | 0.58 | ribosomal | nisin U | Streptococcus uberis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000506.4 |  | 0.89 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii
BGC0000559.4 |  | 0.88 | ribosomal | subtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0002576.2 |  | 0.75 | ribosomal | mechercharmycin | Thermoactinomyces sp.
BGC0000511.5 |  | 0.70 | ribosomal | ericin S | Bacillus subtilis
BGC0000538.3 |  | 0.64 | ribosomal | nisin Z | Lactococcus lactis
BGC0000542.3 |  | 0.60 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0000541.5 |  | 0.60 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0001289.5 |  | 0.59 | ribosomal | penisin | Paenibacillus ehimensis
BGC0000556.5 |  | 0.59 | ribosomal | streptin | Streptococcus pyogenes
BGC0000537.3 |  | 0.58 | ribosomal | nisin U | Streptococcus uberis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for LRO88_RS19070

LRO88_RS19055
Leader:
MSKFDDFDLDVVKVSKQDSKITPQ
Core:
W K S E S L C T P G C V T G V L Q T C F L Q T I T C N C K I S K
Core with dehydrations:
W K Dha E Dha L Cys Dhb P G Cys V Dhb G V L Q Dhb Cys F L Q Dhb I Dhb Cys N Cys K I Dha K

#### antiSMASH-DB 4.0 matches for LRO88_RS19055

100.0%
NZ_CP021903.1 and 20 others:
NZ_CP023409.1 Lanthipeptides: Bateq7PJ16_RS18530_lanthipeptide NZ_CP026036.1 Lanthipeptides: C2H93_RS15000_lanthipeptide NZ_CP028218.1 Lanthipeptides: C7M30_RS14555_lanthipeptide NZ_CP035167.1 Lanthipeptides: EQJ08_RS17140_lanthipeptide NZ_CP035226.1 Lanthipeptides: EQW70_RS18175_lanthipeptide NZ_CP045006.1 Lanthipeptides: F9B13_RS03875_lanthipeptide NZ_CP076083.1 Lanthipeptides: KFF76_RS16710_lanthipeptide NZ_CP079759.1 Lanthipeptides: KXZ66_RS17780_lanthipeptide NZ_CP080508.1 Lanthipeptides: K0V03_RS06525_lanthipeptide NZ_CP089148.1 Lanthipeptides: LRO88_RS19055_lanthipeptide NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04985_lanthipeptide NZ_JALAVX010000009.1 Lanthipeptides: MOE40_RS09385_lanthipeptide NZ_JAMYDW010000007.1 Lanthipeptides: NHM07_RS16180_lanthipeptide NZ_JAQOXM010000001.1 Lanthipeptides: PO770_RS03875_lanthipeptide NZ_NJRD01000003.1 Lanthipeptides: CE053_RS07200_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18435_lanthipeptide NZ_SORJ01000001.1 Lanthipeptides: BJ795_RS01490_lanthipeptide NZ_VFNF01000001.1 Lanthipeptides: FB592_RS01525_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03850_lanthipeptide NZ_VLJL01000012.1 Lanthipeptides: L604_RS09425_lanthipeptide
Lanthipeptides: CD007_RS17065_lanthipeptide
1
W K S E S L C T P G C V T G V L Q T C F L Q T I T C N C K I S K
32
W K S E S L C T P G C V T G V L Q T C F L Q T I T C N C K I S K
1
W K S E S L C T P G C V T G V L Q T C F L Q T I T C N C K I S K
32
93.8%
NC_014479.1 and 9 others:
NZ_CP026362.1 Lanthipeptides: BV11031_RS00400_lanthipeptide NZ_CP033052.1 Lanthipeptides: D9779_RS17315_lanthipeptide NZ_CP051464.1 Lanthipeptides: HC660_RS17030_lanthipeptide NZ_JALAKK010000002.1 Lanthipeptides: MOB09_RS02800_lanthipeptide NZ_JALAKO010000014.1 Lanthipeptides: MOB26_RS08535_lanthipeptide NZ_JALAOG010000003.1 Lanthipeptides: MOC96_RS02500_lanthipeptide NZ_JALAPG010000043.1 Lanthipeptides: MOC70_RS16815_lanthipeptide NZ_JALAQI010000009.1 Lanthipeptides: MOD13_RS06065_lanthipeptide NZ_NXEM01000027.1 Lanthipeptides: CPT06_RS15285_lanthipeptide
Lanthipeptides: BSUW23_RS16845_lanthipeptide
1
W K S E S L C T P G C V T G V L Q T C F L Q T I T C N C K I S K
32
W K S E S L C T P G C V T G L Q T C F L Q T+T C N C K I S K
1
W K S E S L C T P G C V T G A L Q T C F L Q T L T C N C K I S K
32
93.8%
NC_016047.1 and 2 others:
NZ_KZ848487.1 Lanthipeptides: DSL71_RS15965_lanthipeptide NZ_MUXL01000003.1 Lanthipeptides: B0W20_RS12275_lanthipeptide
Lanthipeptides: GYO_RS39160_lanthipeptide
1
W K S E S L C T P G C V T G V L Q T C F L Q T I T C N C K I S K
32
W K S E S+C T P G C V T G+L Q T C F L Q T I T C N C K I S K
1
W K S E S V C T P G C V T G L L Q T C F L Q T I T C N C K I S K
32
with 88 more sequence matches
Only the first 10 are displayed here.
93.8%
NZ_CP025079.1 and 3 others:
NZ_CP047644.1 Lanthipeptides: GNE05_RS17275_lanthipeptide NZ_CP099859.1 Lanthipeptides: NIZ95_RS16280_lanthipeptide NZ_CP101621.1 Lanthipeptides: NN913_RS16115_lanthipeptide
Lanthipeptides: BVQ_RS17705_lanthipeptide
1
W K S E S L C T P G C V T G V L Q T C F L Q T I T C N C K I S K
32
W K S E S+C T P G C V T G V L Q T C F L Q T I T C N C I S K
1
W K S E S V C T P G C V T G V L Q T C F L Q T I T C N C H I S K
32
84.4%
NZ_BMMB01000002.1:
Lanthipeptides: IEX62_RS05935_lanthipeptide
1
W K S E S L C T P G C V T G V L Q T C F L Q T I T C N C K I S K
32
W K S+S C T P G C V T G V L Q T C F+Q T T C N C I S K
1
W K S K S F C T P G C V T G V L Q T C F I Q T A T C N C H I S K
32
84.4%
NZ_CP117416.1 and 1 other:
NZ_JAQQZQ010000001.1 Lanthipeptides: PO903_RS06885_lanthipeptide
Lanthipeptides: PQ456_RS01230_lanthipeptide
1
W K S E S L C T P G C V T G V L Q T C F L Q T I T C N C K I S K
32
W K S+S C T P G C V T G V L Q T C F+Q T T C N C I S K
1
W K S Q S F C T P G C V T G V L Q T C F I Q T A T C N C H I S K
32
62.5%
NZ_AUAQ01000012.1:
Lanthipeptides: G393_RS16160_lanthipeptide
1
W K S E S L C T P G C V T G V L Q T C F L Q T I T C N C K I S K
32
W K S+S L C T P G C+T G+L Q T C +Q+ T C +S+
1
W K S K S L C T P G C I T G I L Q T C A I Q S F T C E V H V S R
32
60.6%
NZ_CP015405.2 and 7 others:
NZ_CP015405.2 Lanthipeptides: A4V09_RS08295_lanthipeptide NZ_CP015405.2 Lanthipeptides: A4V09_RS08290_lanthipeptide NZ_CP015405.2 Lanthipeptides: A4V09_RS08285_lanthipeptide NZ_CP053228.1 Lanthipeptides: HL650_RS06240_lanthipeptide NZ_CP053228.1 Lanthipeptides: HL650_RS06235_lanthipeptide NZ_CP053228.1 Lanthipeptides: HL650_RS06230_lanthipeptide NZ_CP053228.1 Lanthipeptides: HL650_RS06225_lanthipeptide
Lanthipeptides: A4V09_RS08300_lanthipeptide
3
S E S L C T P G C V T G V L Q T C F L Q T I T C N C K I S
31
S+S L C T P G C V T G+L T C +Q T T C C+I+
3
S K S L C T P G C V T G I L M T C P V Q T A T C G C Q I T
31
60.0%
NZ_CP013655.1 and 2 others:
NZ_CP013655.1 Lanthipeptides: ATZ35_RS03635_lanthipeptide NZ_CP013655.1 Lanthipeptides: ATZ35_RS03630_lanthipeptide
Lanthipeptides: ATZ35_RS03640_lanthipeptide
3
S E S L C T P G C V T G V L Q T C F L Q T I T C N C K I S
31
S+S L C T P G C V T G V L C L+T I T C N C +
3
S K S L C T P G C V T G V L M G C A L K T I T C N C S V G
31
58.8%
NZ_JADNFO010000025.1:
Lanthipeptides: I2C89_RS09745_lanthipeptide
3
S E S L C T P G C V T G V L Q T C F L Q T I T C N C K I
30
S S L C T P G C T G V L C L+T T C N C I
3
S Y S L C T P G C K T G V L M A C H L K T A T C N C S I
30
57.6%
NZ_JADNJR010000016.1 and 2 others:
NZ_JADNJR010000016.1 Lanthipeptides: I2E58_RS10875_lanthipeptide NZ_QSHK01000002.1 Lanthipeptides: DW860_RS04740_lanthipeptide
Lanthipeptides: I2E58_RS10880_lanthipeptide
1
W K S E S L C T P G C V T G V L Q T C F L Q T I T C N C K I S
31
+K S+S C T P G C T G+L T C L+T T C C I+
1
Y K S K S A C T P G C P T G I L M T C P L K T A T C G C H I T
31
57.6%
NZ_QSHK01000002.1 and 1 other:
NZ_QSHK01000002.1 Lanthipeptides: DW860_RS04730_lanthipeptide
Lanthipeptides: DW860_RS04735_lanthipeptide
1
W K S E S L C T P G C V T G V L Q T C F L Q T I T C N C K I S
31
+K S+S+C T P G C T G+L T C L+T T C C I+
1
Y K S K S V C T P G C P T G I L M T C P L K T A T C G C H I T
31
54.3%
NZ_FNDP01000013.1:
Lanthipeptides: BLP54_RS11230_lanthipeptide
3
S E S L C T P G C V T G V L Q T C F L Q T I T C N C K I
30
S+S L C T P G C V T G V L C +T T C N C +
5
S K S L C T P G C V T G V L M G C N N K T A T C N C S V
32

#### MIBiG 4.0 matches for LRO88_RS19055

50.0%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
3
S E S L C T P G C V T G V L Q T C F L Q T I T C N C K I
30
S S L C T P G C T G L C ++T T C+C I
3
S I S L C T P G C K T G A L M G C N M K T A T C H C S I
30

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.03 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 26.32 out of 27.78
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.92 out of 27.78
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.28 out of 27.78
Confidence: medium
Lanthipeptides
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

LRO88_RS19055 - Class I
  Cleavage pHMM score: 27.80
  RODEO score: 29
  Monoisotopic mass: 3346.7 Da
  Molecular weight: 3349.0 Da
  Number of bridges: 5
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3367.0 Da N = 1
    3385.0 Da N = 2
    3403.0 Da N = 3

RRE predictions
RREfinder results sidepanel.

lanthipeptide-class-i protocluster (3463828...3490054)
LRO88_RS19070
  RRE type: Lanthipeptide_LanB_RRE
  Location: 146 - 232
  Score: 45.1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MexT | Global virulence regulator
MogR | Repressor of flagellar motility genes

NZ_CP089148.1 - Region 9 - sactipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,851,113 - 3,872,724 nt. (total: 21,612 nt) Show pHMM detection rules used
sactipeptide: (subtilosin or thuricin or TIGR04404 or Subtilosin_A or skfc)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Sactipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: electron transfer
LRO88_RS20945: flavodoxin

smcogs
  SMCOG1134: flavodoxin

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | sactipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000602.5 |  | 0.88 | ribosomal | subtilosin A | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000514.5 |  | 0.38 | ribosomal | gallidermin | Staphylococcus gallinarum
BGC0001170.5 |  | 0.34 | ribosomal | clostridiolysin S | Clostridium sporogenes ATCC 15579
BGC0000564.5 |  | 0.34 | ribosomal | clostridiolysin S | Clostridium botulinum A str. ATCC 3502
BGC0001137.5 |  | 0.34 | other (other) | marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D | Marinactinospora thermotolerans
BGC0002666.2 |  | 0.31 | NRPS, other (other) | Legonmycin A, Legonmycin B, Legonindolizine A, Legonindolizine B | Streptomyces sp. MA37
BGC0000838.3 |  | 0.28 | PKS | flexirubin | Flavobacterium johnsoniae UW101
BGC0002122.2 |  | 0.27 | NRPS | gramicidin S | Aneurinibacillus migulanus
BGC0001048.5 |  | 0.24 | NRPS, PKS, saccharide | tallysomycin A, tallysomycin B | Streptoalloteichus hindustanus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000602.5 |  | 0.88 | ribosomal | subtilosin A | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000514.5 |  | 0.38 | ribosomal | gallidermin | Staphylococcus gallinarum
BGC0001170.5 |  | 0.34 | ribosomal | clostridiolysin S | Clostridium sporogenes ATCC 15579
BGC0000564.5 |  | 0.34 | ribosomal | clostridiolysin S | Clostridium botulinum A str. ATCC 3502
BGC0001137.5 |  | 0.34 | other (other) | marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D | Marinactinospora thermotolerans
BGC0002666.2 |  | 0.31 | NRPS, other (other) | Legonmycin A, Legonmycin B, Legonindolizine A, Legonindolizine B | Streptomyces sp. MA37
BGC0000838.3 |  | 0.28 | PKS | flexirubin | Flavobacterium johnsoniae UW101
BGC0002122.2 |  | 0.27 | NRPS | gramicidin S | Aneurinibacillus migulanus
BGC0001048.5 |  | 0.24 | NRPS, PKS, saccharide | tallysomycin A, tallysomycin B | Streptoalloteichus hindustanus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Sactipeptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Each core peptide shows the leader and core peptide sequences.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Sactipeptide(s) for LRO88_RS20980

LRO88_RS20980
Leader:
MKKAVIVENK
Core:
G C A T C S I G A A C L V D G P I P D F E I A G A T G L F G L W G

#### antiSMASH-DB 4.0 matches for LRO88_RS20980

100.0%
NC_000964.3 and 235 others:
NC_014479.1 Sactipeptides: BSUW23_RS18740_sactipeptide NC_014639.1 Sactipeptides: BATR1942_RS15950_sactipeptide NC_014976.1 Sactipeptides: BSN5_RS09700_sactipeptide NC_016047.1 Sactipeptides: GYO_RS41165_sactipeptide NC_017195.1 Sactipeptides: I33_RS18040_sactipeptide NC_017743.1 Sactipeptides: MY9_RS18920_sactipeptide NC_019896.1 Sactipeptides: A7A1_RS01935_sactipeptide NC_020244.1 Sactipeptides: C663_RS18295_sactipeptide NZ_BDDH01000003.1 Sactipeptides: A7P71_RS10610_sactipeptide NZ_CABIVP010000002.1 Sactipeptides: FY199_RS09010_sactipeptide NZ_CP007409.1 Sactipeptides: Q433_RS18950_sactipeptide NZ_CP009796.1 Sactipeptides: OB04_RS19085_sactipeptide NZ_CP011101.1 Sactipeptides: bslm_RS18365_sactipeptide NZ_CP011534.1 Sactipeptides: ABA10_RS18725_sactipeptide NZ_CP011802.1 Sactipeptides: D068_RS17505_sactipeptide NZ_CP016767.1 Sactipeptides: BCV50_RS14935_sactipeptide NZ_CP017072.1 Sactipeptides: BGM23_RS02945_sactipeptide NZ_CP017112.1 Sactipeptides: BS16045_RS19810_sactipeptide NZ_CP017313.1 Sactipeptides: BH660_RS14630_sactipeptide NZ_CP017314.1 Sactipeptides: BSBS38_RS19215_sactipeptide NZ_CP017676.1 Sactipeptides: BKN48_RS08085_sactipeptide NZ_CP018173.1 Sactipeptides: BAX60_RS03615_sactipeptide NZ_CP020367.1 Sactipeptides: BSK2_RS19060_sactipeptide NZ_CP020722.1 Sactipeptides: B7470_RS09560_sactipeptide NZ_CP020915.1 Sactipeptides: B9L64_RS11255_sactipeptide NZ_CP021169.1 Sactipeptides: B9N48_RS18685_sactipeptide NZ_CP021498.1 Sactipeptides: S101444_RS19170_sactipeptide NZ_CP021892.1 Sactipeptides: S100333_RS19720_sactipeptide NZ_CP021903.1 Sactipeptides: CD007_RS18975_sactipeptide NZ_CP021911.1 Sactipeptides: CDO84_RS18225_sactipeptide NZ_CP021921.1 Sactipeptides: S101392_RS19440_sactipeptide NZ_CP022391.1 Sactipeptides: CFK25_RS18875_sactipeptide NZ_CP022890.1 Sactipeptides: CJZ70_RS01210_sactipeptide NZ_CP023257.1 Sactipeptides: CLD04_RS19470_sactipeptide NZ_CP023409.1 Sactipeptides: Bateq7PJ16_RS20450_sactipeptide NZ_CP025941.1 Sactipeptides: C0W65_RS07300_sactipeptide NZ_CP026010.1 Sactipeptides: BS11774_RS03710_sactipeptide NZ_CP026030.1 Sactipeptides: C2H91_RS12110_sactipeptide NZ_CP026035.1 Sactipeptides: C2H96_RS13375_sactipeptide NZ_CP026036.1 Sactipeptides: C2H93_RS16885_sactipeptide NZ_CP026521.1 Sactipeptides: C1T29_RS22385_sactipeptide NZ_CP028201.1 Sactipeptides: C7M16_RS17535_sactipeptide NZ_CP028202.1 Sactipeptides: C7M17_RS17600_sactipeptide NZ_CP028217.1 Sactipeptides: C7M29_RS06900_sactipeptide NZ_CP028218.1 Sactipeptides: C7M30_RS12605_sactipeptide NZ_CP028812.1 Sactipeptides: DAE22_RS20770_sactipeptide NZ_CP029364.1 Sactipeptides: DIC78_RS12275_sactipeptide NZ_CP029461.1 Sactipeptides: DJ572_RS18795_sactipeptide NZ_CP029465.1 Sactipeptides: DKG76_RS19825_sactipeptide NZ_CP029609.1 Sactipeptides: DL538_RS20030_sactipeptide NZ_CP031675.1 Sactipeptides: DYS67_RS19275_sactipeptide NZ_CP031783.1 Sactipeptides: D0808_RS00710_sactipeptide NZ_CP031784.1 Sactipeptides: D0819_RS14700_sactipeptide NZ_CP032853.1 Sactipeptides: D9C10_RS17955_sactipeptide NZ_CP032855.1 Sactipeptides: D9C11_RS09165_sactipeptide NZ_CP035161.1 Sactipeptides: EQH88_RS19675_sactipeptide NZ_CP035167.1 Sactipeptides: EQJ08_RS19095_sactipeptide NZ_CP035226.1 Sactipeptides: EQW70_RS20085_sactipeptide NZ_CP035231.1 Sactipeptides: EQZ01_RS19685_sactipeptide NZ_CP035391.1 Sactipeptides: ES965_RS19370_sactipeptide NZ_CP035395.1 Sactipeptides: ES968_RS19740_sactipeptide NZ_CP035401.1 Sactipeptides: ETA19_RS19595_sactipeptide NZ_CP035402.1 Sactipeptides: ES969_RS19660_sactipeptide NZ_CP035403.1 Sactipeptides: ETA15_RS19805_sactipeptide NZ_CP035406.1 Sactipeptides: ETK61_RS20735_sactipeptide NZ_CP035413.1 Sactipeptides: ETL58_RS19505_sactipeptide NZ_CP039935.1 Sactipeptides: FCJ76_RS19255_sactipeptide NZ_CP045006.1 Sactipeptides: F9B13_RS01950_sactipeptide NZ_CP045425.1 Sactipeptides: GCU76_RS20710_sactipeptide NZ_CP045816.1 Sactipeptides: GII86_RS19920_sactipeptide NZ_CP045824.1 Sactipeptides: GII78_RS20125_sactipeptide NZ_CP046591.1 Sactipeptides: GO004_RS15965_sactipeptide NZ_CP046860.1 Sactipeptides: GPJ55_RS11605_sactipeptide NZ_CP047645.1 Sactipeptides: GSN02_RS19265_sactipeptide NZ_CP049924.1 Sactipeptides: G4G26_RS18960_sactipeptide NZ_CP050705.1 Sactipeptides: HCU65_RS18920_sactipeptide NZ_CP051462.1 Sactipeptides: HC662_RS19240_sactipeptide NZ_CP051464.1 Sactipeptides: HC660_RS18970_sactipeptide NZ_CP054050.1 Sactipeptides: HNV25_RS02005_sactipeptide NZ_CP054177.1 Sactipeptides: HR084_RS18935_sactipeptide NZ_CP054584.1 Sactipeptides: HT135_RS19775_sactipeptide NZ_CP060193.1 Sactipeptides: H7F27_RS02180_sactipeptide NZ_CP060417.1 Sactipeptides: H8S71_RS18495_sactipeptide NZ_CP061284.1 Sactipeptides: ICJ61_RS19715_sactipeptide NZ_CP061870.1 Sactipeptides: IE382_RS22305_sactipeptide NZ_CP062497.1 Sactipeptides: IHV08_RS19770_sactipeptide NZ_CP063276.1 Sactipeptides: IM743_RS18070_sactipeptide NZ_CP065858.1 Sactipeptides: I7X10_RS03370_sactipeptide NZ_CP069789.1 Sactipeptides: JR441_RS19085_sactipeptide NZ_CP070483.1 Sactipeptides: JQX68_RS19175_sactipeptide NZ_CP070976.1 Sactipeptides: JYG31_RS19675_sactipeptide NZ_CP071043.1 Sactipeptides: JS609_RS19245_sactipeptide NZ_CP073265.1 Sactipeptides: KCX77_RS18900_sactipeptide NZ_CP075344.1 Sactipeptides: KIL00_RS20100_sactipeptide NZ_CP076083.1 Sactipeptides: KFF76_RS18635_sactipeptide NZ_CP079759.1 Sactipeptides: KXZ66_RS19695_sactipeptide NZ_CP080508.1 Sactipeptides: K0V03_RS08595_sactipeptide NZ_CP089148.1 Sactipeptides: LRO88_RS20980_sactipeptide NZ_CP090125.1 Sactipeptides: LXE94_RS19505_sactipeptide NZ_CP093289.1 Sactipeptides: MNG38_RS19730_sactipeptide NZ_CP093546.1 Sactipeptides: MOW04_RS19180_sactipeptide NZ_CP095736.1 Sactipeptides: MX663_RS20090_sactipeptide NZ_CP096590.1 Sactipeptides: M0696_RS18995_sactipeptide NZ_CP096889.1 Sactipeptides: EFK13_RS19225_sactipeptide NZ_CP098738.1 Sactipeptides: NDR85_RS18965_sactipeptide NZ_CP100651.1 Sactipeptides: NLW79_RS19990_sactipeptide NZ_CP100752.1 Sactipeptides: NLV76_RS19060_sactipeptide NZ_CP101718.1 Sactipeptides: NPA28_RS19075_sactipeptide NZ_CP101936.1 Sactipeptides: NP434_RS18980_sactipeptide NZ_CP103352.1 Sactipeptides: NX823_RS19780_sactipeptide NZ_CP104878.1 Sactipeptides: N8A75_RS20105_sactipeptide NZ_CP107539.1 Sactipeptides: OEG95_RS19105_sactipeptide NZ_CP110264.1 Sactipeptides: OMK57_RS18975_sactipeptide NZ_CP114899.1 Sactipeptides: O6U12_RS19480_sactipeptide NZ_CP116773.1 Sactipeptides: PNF29_RS01990_sactipeptide NZ_FTMW01000001.1 Sactipeptides: BW968_RS02045_sactipeptide NZ_JAAUXF010000005.1 Sactipeptides: HC742_RS19325_sactipeptide NZ_JABRUZ010000003.1 Sactipeptides: HRF55_RS03085_sactipeptide NZ_JABRVH010000018.1 Sactipeptides: HRF53_RS09100_sactipeptide NZ_JABUKD010000002.1 Sactipeptides: HRW04_RS09345_sactipeptide NZ_JAEACL010000001.1 Sactipeptides: I5F14_RS00800_sactipeptide NZ_JAHVOC010000002.1 Sactipeptides: KXD37_RS07830_sactipeptide NZ_JAJFDG010000003.1 Sactipeptides: LJF29_RS11575_sactipeptide NZ_JAJHUI010000011.1 Sactipeptides: LK399_RS16325_sactipeptide NZ_JALAJC010000012.1 Sactipeptides: MOB18_RS16080_sactipeptide NZ_JALAKW010000005.1 Sactipeptides: MOB93_RS12665_sactipeptide NZ_JALAKZ010000001.1 Sactipeptides: MOB76_RS02240_sactipeptide NZ_JALALA010000011.1 Sactipeptides: MOB82_RS15020_sactipeptide NZ_JALALE010000020.1 Sactipeptides: MOB33_RS20855_sactipeptide NZ_JALALO010000006.1 Sactipeptides: MOB75_RS09230_sactipeptide NZ_JALAMD010000002.1 Sactipeptides: MOB22_RS02315_sactipeptide NZ_JALAME010000005.1 Sactipeptides: MOC02_RS13805_sactipeptide NZ_JALAMJ010000012.1 Sactipeptides: MOB80_RS16635_sactipeptide NZ_JALAMO010000007.1 Sactipeptides: MOB98_RS08535_sactipeptide NZ_JALAMR010000019.1 Sactipeptides: MOC09_RS17975_sactipeptide NZ_JALAMZ010000002.1 Sactipeptides: MOC43_RS01370_sactipeptide NZ_JALANN010000012.1 Sactipeptides: MOC49_RS18290_sactipeptide NZ_JALANX010000001.1 Sactipeptides: MOC25_RS03365_sactipeptide NZ_JALAPT010000001.1 Sactipeptides: MOC95_RS01580_sactipeptide NZ_JALAPV010000005.1 Sactipeptides: MOC91_RS13515_sactipeptide NZ_JALAPW010000003.1 Sactipeptides: MOD18_RS06235_sactipeptide NZ_JALAPX010000003.1 Sactipeptides: MOC97_RS06805_sactipeptide NZ_JALAPZ010000002.1 Sactipeptides: MOC81_RS03830_sactipeptide NZ_JALAQA010000008.1 Sactipeptides: MOD07_RS14955_sactipeptide NZ_JALAQC010000001.1 Sactipeptides: MOD00_RS01290_sactipeptide NZ_JALAQD010000002.1 Sactipeptides: MOD08_RS05770_sactipeptide NZ_JALAQE010000002.1 Sactipeptides: MOD19_RS04725_sactipeptide NZ_JALASB010000002.1 Sactipeptides: MOD42_RS03685_sactipeptide NZ_JALASC010000024.1 Sactipeptides: MOD69_RS20580_sactipeptide NZ_JALASM010000006.1 Sactipeptides: MOD51_RS10970_sactipeptide NZ_JALASR010000006.1 Sactipeptides: MOD87_RS10780_sactipeptide NZ_JALAST010000011.1 Sactipeptides: MOE17_RS14670_sactipeptide NZ_JALASW010000005.1 Sactipeptides: MOE15_RS06925_sactipeptide NZ_JALATC010000001.1 Sactipeptides: MOD56_RS03380_sactipeptide NZ_JALATD010000001.1 Sactipeptides: MOE02_RS03350_sactipeptide NZ_JALATE010000006.1 Sactipeptides: MOD98_RS11440_sactipeptide NZ_JALATF010000003.1 Sactipeptides: MOD44_RS09960_sactipeptide NZ_JALATG010000002.1 Sactipeptides: MOE16_RS03490_sactipeptide NZ_JALATJ010000007.1 Sactipeptides: MOD90_RS15770_sactipeptide NZ_JALATU010000001.1 Sactipeptides: MOE27_RS01985_sactipeptide NZ_JALATV010000005.1 Sactipeptides: MOD97_RS07020_sactipeptide NZ_JALAUA010000008.1 Sactipeptides: MOD32_RS16030_sactipeptide NZ_JALAUD010000001.1 Sactipeptides: MOE28_RS03345_sactipeptide NZ_JALAUJ010000006.1 Sactipeptides: MOE37_RS12685_sactipeptide NZ_JALAUK010000012.1 Sactipeptides: MOE38_RS11825_sactipeptide NZ_JALAUV010000003.1 Sactipeptides: MOE71_RS06545_sactipeptide NZ_JALAUW010000015.1 Sactipeptides: MOE83_RS13210_sactipeptide NZ_JALAVA010000002.1 Sactipeptides: MOE81_RS02625_sactipeptide NZ_JALAVE010000001.1 Sactipeptides: MOE67_RS03645_sactipeptide NZ_JALAVI010000011.1 Sactipeptides: MOE80_RS14660_sactipeptide NZ_JALAVK010000006.1 Sactipeptides: MOE96_RS10120_sactipeptide NZ_JALAVL010000002.1 Sactipeptides: MOE60_RS03290_sactipeptide NZ_JALAVM010000009.1 Sactipeptides: MOE49_RS16195_sactipeptide NZ_JALAVO010000008.1 Sactipeptides: MOE63_RS14665_sactipeptide NZ_JALAVQ010000003.1 Sactipeptides: MOE59_RS02420_sactipeptide NZ_JALAVS010000002.1 Sactipeptides: MOE46_RS02250_sactipeptide NZ_JALAVT010000005.1 Sactipeptides: MOF25_RS08325_sactipeptide NZ_JALAVU010000004.1 Sactipeptides: MOE78_RS09660_sactipeptide NZ_JALAVV010000004.1 Sactipeptides: MOE66_RS02855_sactipeptide NZ_JALAVW010000001.1 Sactipeptides: MOE86_RS01005_sactipeptide NZ_JALAVX010000009.1 Sactipeptides: MOE40_RS07525_sactipeptide NZ_JALAVZ010000002.1 Sactipeptides: MOF00_RS02525_sactipeptide NZ_JALAWB010000008.1 Sactipeptides: MOE87_RS15020_sactipeptide NZ_JALAWK010000002.1 Sactipeptides: MOF06_RS12140_sactipeptide NZ_JALAWW010000010.1 Sactipeptides: MOF23_RS17300_sactipeptide NZ_JALAXQ010000012.1 Sactipeptides: MOF24_RS14120_sactipeptide NZ_JALAXV010000001.1 Sactipeptides: MOF15_RS00375_sactipeptide NZ_JALAYA010000016.1 Sactipeptides: MOF34_RS08915_sactipeptide NZ_JALAYD010000019.1 Sactipeptides: MOF39_RS20725_sactipeptide NZ_JALNTO010000006.1 Sactipeptides: MTN95_RS11045_sactipeptide NZ_JAMDFN010000008.1 Sactipeptides: M3M31_RS18245_sactipeptide NZ_JAMYDW010000003.1 Sactipeptides: NHM07_RS10830_sactipeptide NZ_JANBMP010000002.1 Sactipeptides: NL430_RS07940_sactipeptide NZ_JANDGG010000001.1 Sactipeptides: NKU38_RS03365_sactipeptide NZ_JANFAP010000001.1 Sactipeptides: NEC81_RS02065_sactipeptide NZ_JAQFFE010000015.1 Sactipeptides: PG051_RS13540_sactipeptide NZ_JAQOXM010000001.1 Sactipeptides: PO770_RS01950_sactipeptide NZ_JH600279.1 Sactipeptides: GYU_RS0104160_sactipeptide NZ_JXHL01000020.1 Sactipeptides: B4069_RS07025_sactipeptide NZ_JXHP01000031.1 Sactipeptides: B4073_RS09425_sactipeptide NZ_JXHR01000010.1 Sactipeptides: B4146_RS06925_sactipeptide NZ_KZ848487.1 Sactipeptides: DSL71_RS14015_sactipeptide NZ_LPVE01000021.1 Sactipeptides: AU385_RS06600_sactipeptide NZ_LSBB01000001.1 Sactipeptides: AXI57_RS01770_sactipeptide NZ_LUUT01000004.1 Sactipeptides: A6751_RS18460_sactipeptide NZ_MOEO01000004.1 Sactipeptides: BLL41_RS09830_sactipeptide NZ_MUXL01000002.1 Sactipeptides: B0W20_RS08845_sactipeptide NZ_MZZI01000001.1 Sactipeptides: B2G85_RS18515_sactipeptide NZ_NBBO01000003.1 Sactipeptides: B6K89_RS01830_sactipeptide NZ_NERK01000024.1 Sactipeptides: B9T64_RS18540_sactipeptide NZ_NJRD01000003.1 Sactipeptides: CE053_RS09115_sactipeptide NZ_NJRE01000002.1 Sactipeptides: CE047_RS07205_sactipeptide NZ_NKAK01000003.1 Sactipeptides: CE489_RS10400_sactipeptide NZ_NMOM01000004.1 Sactipeptides: CFI07_RS07245_sactipeptide NZ_PHIE01000002.1 Sactipeptides: CVV77_RS10760_sactipeptide NZ_PJCT01000002.1 Sactipeptides: CW370_RS11825_sactipeptide NZ_PVQM01000002.1 Sactipeptides: C6W22_RS11490_sactipeptide NZ_PVQN01000002.1 Sactipeptides: C6W23_RS05885_sactipeptide NZ_PVRK01000001.1 Sactipeptides: C6350_RS02025_sactipeptide NZ_PVWC01000004.1 Sactipeptides: C6372_RS11675_sactipeptide NZ_QRFZ01000012.1 Sactipeptides: DXT72_RS19010_sactipeptide NZ_SDKE01000003.1 Sactipeptides: EUA35_RS12130_sactipeptide NZ_SHOB01000002.1 Sactipeptides: ES060_RS14270_sactipeptide NZ_SIRN01000006.1 Sactipeptides: EYH65_RS15720_sactipeptide NZ_SNWK01000001.1 Sactipeptides: DFO69_RS02055_sactipeptide NZ_SOBO01000012.1 Sactipeptides: DFO78_RS18210_sactipeptide NZ_SORJ01000001.1 Sactipeptides: BJ795_RS03350_sactipeptide NZ_VBRP01000025.1 Sactipeptides: FE220_RS07065_sactipeptide NZ_VFNF01000001.1 Sactipeptides: FB592_RS03405_sactipeptide NZ_VIOH01000001.1 Sactipeptides: FLN47_RS01935_sactipeptide NZ_VLJK01000012.1 Sactipeptides: L605_RS10195_sactipeptide NZ_VLJL01000006.1 Sactipeptides: L604_RS05585_sactipeptide NZ_VLJX01000001.1 Sactipeptides: L609_RS01950_sactipeptide NZ_VTEK01000003.1 Sactipeptides: FZC71_RS10310_sactipeptide NZ_WTKJ01000004.1 Sactipeptides: NWT17_RS06185_sactipeptide
Sactipeptides: BSU_37350_sactipeptide
1
G C A T C S I G A A C L V D G P I P D F E I A G A T G L F G L W G
33
G C A T C S I G A A C L V D G P I P D F E I A G A T G L F G L W G
1
G C A T C S I G A A C L V D G P I P D F E I A G A T G L F G L W G
33
97.0%
NZ_CP092751.1:
Sactipeptides: MKF32_RS18515_sactipeptide
1
G C A T C S I G A A C L V D G P I P D F E I A G A T G L F G L W G
33
G C A T C S I G A C L V D G P I P D F E I A G A T G L F G L W G
1
G C A T C S I G A V C L V D G P I P D F E I A G A T G L F G L W G
33
93.9%
NZ_CP048852.1:
Sactipeptides: G4P54_RS19300_sactipeptide
1
G C A T C S I G A A C L V D G P I P D F E I A G A T G L F G L W G
33
G C A T C S I G A C L V D G P I P D F E+A G A T G L F G L W G
1
G C A T C S I G A V C L V D G P I P D F E V A G A T G L F G L W G
33
with 15 more sequence matches
Only the first 10 are displayed here.
90.9%
NZ_JALAKO010000018.1 and 1 other:
NZ_JALAOG010000035.1 Sactipeptides: MOC96_RS18415_sactipeptide
Sactipeptides: MOB26_RS11095_sactipeptide
1
G C A T C S I G A A C L V D G P I P D F E I A G A T G L F G L W G
33
G C A T C S I G A C L V D G P I P D F E I G T G L F G L W G
1
G C A T C S I G A V C L V D G P I P D F E I G G V T G L F G L W G
33
87.9%
NZ_CP026362.1 and 3 others:
NZ_CP033052.1 Sactipeptides: D9779_RS19215_sactipeptide NZ_JALAPG010000031.1 Sactipeptides: MOC70_RS13155_sactipeptide NZ_JALAQI010000016.1 Sactipeptides: MOD13_RS11485_sactipeptide
Sactipeptides: BV11031_RS20865_sactipeptide
1
G C A T C S I G A A C L V D G P I P D F E I A G A T G L F G L W G
33
G C A T C S I G A C L V D G I P D F E I G T G L F G L W G
1
G C A T C S I G A V C L V D G F I P D F E I G G V T G L F G L W G
33
78.8%
NZ_NXEM01000021.1:
Sactipeptides: CPT06_RS05595_sactipeptide
1
G C A T C S I G A A C L V D G P I P D F E I A G A T G L F G L W G
33
G C T C S I G A C L V+G P I P D F+ G T G L F G L W G
1
G C T T C S I G A V C L V N G P I P D F K T G G V T G L F G L W G
33
72.7%
NC_014925.1 and 17 others:
NZ_ANOI01000001.1 Sactipeptides: F779_RS13290_sactipeptide NZ_CP031604.1 Sactipeptides: DNJ55_RS07055_sactipeptide NZ_CP031605.1 Sactipeptides: DRC71_RS00165_sactipeptide NZ_CP035741.1 Sactipeptides: EW136_RS01865_sactipeptide NZ_CP039747.1 Sactipeptides: EFT29_RS00935_sactipeptide NZ_CP054206.2 Sactipeptides: HP560_RS11995_sactipeptide NZ_CP060700.1 Sactipeptides: H9Q12_RS10940_sactipeptide NZ_CP065920.1 Sactipeptides: JC281_RS11580_sactipeptide NZ_CP076465.1 Sactipeptides: KDE16_RS00560_sactipeptide NZ_JANPRJ010000013.1 Sactipeptides: NVR03_RS10250_sactipeptide NZ_JANPRN010000039.1 Sactipeptides: NVR04_RS07875_sactipeptide NZ_JTKO01000012.1 Sactipeptides: NO87_RS10650_sactipeptide NZ_LR134267.1 Sactipeptides: EL085_RS11430_sactipeptide NZ_MQMO01000006.1 Sactipeptides: BSR38_RS07375_sactipeptide NZ_MQNF01000024.1 Sactipeptides: BSR36_RS12515_sactipeptide NZ_QQPJ01000025.1 Sactipeptides: DV949_RS11300_sactipeptide NZ_SEZW01000001.1 Sactipeptides: EWV33_RS08610_sactipeptide
Sactipeptides: SPSINT_RS00615_sactipeptide
1
G C A T C S I G A A C L V D G P I P D F E I A G A T G L F G L
31
G C+T C S I G A A C L+D G P+P D F E+ G T G+F G L
1
G C S T C S I G A A C L I D G P L P D F E V M G I T G I F G L
31
69.7%
NZ_CP027770.1:
Sactipeptides: C7J90_RS04260_sactipeptide
1
G C A T C S I G A A C L V D G P I P D F E I A G A T G L F G L
31
G C+ C S I G A A C L+D G P P D F E+ G T G F G L
1
G C S A C S I G A A C L I D G P F P D F E V M G I T G T F G L
31
69.7%
NZ_CP066885.1:
Sactipeptides: JGZ27_RS11325_sactipeptide
1
G C A T C S I G A A C L V D G P I P D F E I A G A T G L F G L
31
G C+T C S I G A C L+D G P+P D F E+ G T G+F G L
1
G C S T C S I G V A C L I D G P L P D F E V M G I T G I F G L
31
69.7%
NZ_CP094808.1 and 3 others:
NZ_CP094809.1 Sactipeptides: MUA95_RS01320_sactipeptide NZ_CP094813.1 Sactipeptides: MUA84_RS01300_sactipeptide NZ_VKCY01000004.1 Sactipeptides: FNK43_RS05155_sactipeptide
Sactipeptides: MUA11_RS01375_sactipeptide
1
G C A T C S I G A A C L V D G P I P D F E I A G A T G L F G L
31
G C+ C+I G A A C L D G P I P D F E+A G T G F G+
1
G C S A C A I G A A C L A D G P I P D F E V A G I T G T F G I
31
66.7%
NZ_ATDF02000020.1 and 1 other:
NZ_KV827785.1 Sactipeptides: HMPREF2580_RS10900_sactipeptide
Sactipeptides: M462_RS08950_sactipeptide
1
G C A T C S I G A A C L V D G P I P D F E I A G A T G L F G L
31
G C+ C++G A A C L D G P I P D F E+A G T G F G+
1
G C S A C A V G A A C L A D G P I P D F E V A G I T G T F G M
31
63.6%
NC_022584.1 and 2 others:
NZ_CP047883.1 Sactipeptides: M594_RS05585_sactipeptide NZ_KV802690.1 Sactipeptides: HMPREF2764_RS03300_sactipeptide
Sactipeptides: N596_RS03165_sactipeptide
1
G C A T C S I G A A C L V D G P I P D F E I A G A T G L F G L W G
33
G C+ C+I G A C L D G P I P D F E I A G + +F +G
1
G C S V C A I G A V C L A D G P I P D F E I A G V S A V F T A F G
33
63.6%
NZ_CP063367.1 and 1 other:
NZ_LR134263.1 Sactipeptides: EL101_RS12790_sactipeptide
Sactipeptides: IPU22_RS12430_sactipeptide
1
G C A T C S I G A A C L V D G P I P D F E I A G A T G L F G L
31
G C+ C++G A C L D G P I P D F E+A G T G F G+
1
G C S A C A V G A V C L A D G P I P D F E V A G I T G T F G I
31
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.21 out of 23.79
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.26 out of 19.26
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.64 out of 27.78
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.26 out of 19.26
Confidence: strong
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 25.99 out of 30.25
Confidence: medium
Additional weak hits (4):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.07 out of 26.06
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 21.71 out of 33.73
Confidence: weak
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 21.20 out of 27.18
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.81 out of 33.14
Confidence: weak
RREFinder
Sactipeptides
TFBS Finder
RRE predictions
RREfinder results sidepanel.

sactipeptide protocluster (3851112...3872724)
LRO88_RS20990
  RRE type: Subtilosin_rSAM_RRE
  Location: 5 - 97
  Score: 98.4

Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its RODEO score and predicted core sequence.

LRO88_RS20980
  Putative sactipeptide
  RODEO score: 33.0
  Core sequence, approximate: GCATCSIGAACLVDGPIPDFEIAGATGLFGLWG

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
IolR | Regulator of the inositol catabolism

NZ_CP089148.1 - Region 10 - other
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,876,027 - 3,917,445 nt. (total: 41,419 nt) Show pHMM detection rules used
other: (Neocarzinostat or bcpB or frbD or mitE or prnB or CaiA or bacilysin or orf2_PTase)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
LRO88_RS21150: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

LRO88_RS21170: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

LRO88_RS21200: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

Transferases: aminotransferase transferase
LRO88_RS21155: aminotransferase

smcogs
  SMCOG1019: aminotransferase

LRO88_RS21230: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs
  SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

LRO88_RS21255: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs
  SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

Lyases: dehydratase lyase
LRO88_RS21165: argininosuccinate lyase/adenylosuccinate lyase

smcogs
  SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

LRO88_RS21220: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

LRO88_RS21225: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Translocases: permease
LRO88_RS21190: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | other | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001184.4 |  | 0.84 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0000888.5 |  | 0.83 | other (other) | bacilysin | Bacillus sp. CS93
BGC0000898.5 |  | 0.55 | saccharide | desosamine, pikromycin, neomethymycin, narbomycin | Streptomyces venezuelae
BGC0000790.3 |  | 0.54 | saccharide | O-antigen | Escherichia coli
BGC0000794.5 |  | 0.53 | saccharide | S-layer glycan | Geobacillus stearothermophilus
BGC0001817.5 |  | 0.52 | other (other) | vancosamine | Streptomyces sp. WAC2288
BGC0000899.4 |  | 0.52 | saccharide | desosamine | Streptomyces narbonensis
BGC0000791.3 |  | 0.52 | saccharide | O-antigen | Cronobacter sakazakii
BGC0000773.3 |  | 0.51 | saccharide | lipopolysaccharide | Escherichia coli
BGC0000827.3 |  | 0.51 | other (other) | staurosporine | Salinispora arenicola CNS-205

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001184.4 |  | 0.84 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0000888.5 |  | 0.83 | other (other) | bacilysin | Bacillus sp. CS93
BGC0000898.5 |  | 0.55 | saccharide | desosamine, pikromycin, neomethymycin, narbomycin | Streptomyces venezuelae
BGC0000790.3 |  | 0.54 | saccharide | O-antigen | Escherichia coli
BGC0000794.5 |  | 0.53 | saccharide | S-layer glycan | Geobacillus stearothermophilus
BGC0001817.5 |  | 0.52 | other (other) | vancosamine | Streptomyces sp. WAC2288
BGC0000899.4 |  | 0.52 | saccharide | desosamine | Streptomyces narbonensis
BGC0000791.3 |  | 0.52 | saccharide | O-antigen | Cronobacter sakazakii
BGC0000773.3 |  | 0.51 | saccharide | lipopolysaccharide | Escherichia coli
BGC0000827.3 |  | 0.51 | other (other) | staurosporine | Salinispora arenicola CNS-205

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Location:
Identifier
Identity
Coverage
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.49 out of 20.47
Confidence: medium
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.85 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.36 out of 27.78
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.33 out of 20.97
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.05 out of 27.78
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.92 out of 30.25
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.70 out of 26.06
Confidence: medium
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.15 out of 20.01
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.25 out of 20.97
Confidence: medium
Additional weak hits (15):
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.82 out of 27.55
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.24 out of 36.54
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 23.27 out of 36.54
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.80 out of 29.38
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.37 out of 20.01
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.68 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.11 out of 29.38
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.11 out of 36.54
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.01 out of 36.54
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.86 out of 32.74
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.64 out of 26.06
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.18 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.01 out of 29.38
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.52 out of 29.65
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArgR | Regulator of arginine biosynthesis genes
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
MogR | Repressor of flagellar motility genes
RpoN | Regulator of nitrogen assimilation and virulence
ToxT | Regulator of MSHA biosynthesis
VqsM | Regulator of quorum-sensing signalling systems

NZ_CP089148.1 - Region 11 - epipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,144,821 - 4,166,519 nt. (total: 21,699 nt) Show pHMM detection rules used
epipeptide: (TIGR04078 and yydH)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase reductase
LRO88_RS22420: 3-hydroxyisobutyrate dehydrogenase

smcogs
  SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

LRO88_RS22425: alkyl hydroperoxide reductase/ Thiol specific

smcogs
  SMCOG1196: alkyl hydroperoxide reductase/ Thiol specific

LRO88_RS22430: alkyl hydroperoxide reductase subunit

smcogs
  SMCOG1176: alkyl hydroperoxide reductase subunit

LRO88_RS22510: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | epipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0000490.5 |  | 0.39 | ribosomal | garvicin ML | Lactococcus garvieae DCC43
BGC0000728.5 |  | 0.36 | saccharide | capsular polysaccharide | Klebsiella pneumoniae subsp. ozaenae
BGC0000729.3 |  | 0.36 | saccharide | capsular polysaccharide | Klebsiella pneumoniae
BGC0001285.5 |  | 0.35 | other (fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0000498.5 |  | 0.35 | ribosomal | bovicin HJ50 | Streptococcus equinus
BGC0000561.5 |  | 0.35 | ribosomal | thermophilin 1277 | Streptococcus thermophilus
BGC0001464.3 |  | 0.35 | other (other) | tetrabromopyrrole | Pseudoalteromonas sp. PS5
BGC0001365.3 |  | 0.35 | NRPS | dithioclapurine, trithioclapurine, tetrathioclapurine | Claviceps purpurea 20.1
BGC0001787.3 |  | 0.34 | ribosomal | suicin 3908 | Streptococcus suis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0000490.5 |  | 0.39 | ribosomal | garvicin ML | Lactococcus garvieae DCC43
BGC0000728.5 |  | 0.36 | saccharide | capsular polysaccharide | Klebsiella pneumoniae subsp. ozaenae
BGC0000729.3 |  | 0.36 | saccharide | capsular polysaccharide | Klebsiella pneumoniae
BGC0001285.5 |  | 0.35 | other (fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0000498.5 |  | 0.35 | ribosomal | bovicin HJ50 | Streptococcus equinus
BGC0000561.5 |  | 0.35 | ribosomal | thermophilin 1277 | Streptococcus thermophilus
BGC0001464.3 |  | 0.35 | other (other) | tetrabromopyrrole | Pseudoalteromonas sp. PS5
BGC0001365.3 |  | 0.35 | NRPS | dithioclapurine, trithioclapurine, tetrathioclapurine | Claviceps purpurea 20.1
BGC0001787.3 |  | 0.34 | ribosomal | suicin 3908 | Streptococcus suis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.04 out of 29.25
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.45 out of 32.93
Confidence: medium
Additional weak hits (1):
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.46 out of 20.47
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
LexA variant 3 | Repressor of DNA damage response
SypG | Regulator of biofilm formation and host colonization