LOCUS       NZ_CP088109            20915 bp    DNA     circular CON 31-JAN-2024
DEFINITION  Sinorhizobium medicae WSM1115 chromosome, complete genome.
ACCESSION   NZ_CP088109
VERSION     NZ_CP088109.1
KEYWORDS    RefSeq.
SOURCE      Sinorhizobium medicae WSM1115 (Ensifer medicae WSM1115)
  ORGANISM  Sinorhizobium medicae WSM1115
            Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
            Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
REFERENCE   1  (bases 1 to 4106266)
  AUTHORS   Kohlmeier,M.G., O'Hara,G.W., Colombi,E., Ramsay,J.P. and
            Terpolilli,J.
  TITLE     Australian commercial rhizobial inoculants
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4106266)
  AUTHORS   Kohlmeier,M.G., O'Hara,G.W., Colombi,E., Ramsay,J.P. and
            Terpolilli,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-NOV-2021) Legume Rhizobium Sciences, Murdoch
            University, 90 South Street, Murdoch, WA 6150, Australia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye v. 2.8.3-b1695
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 149x; 384x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina NextSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/31/2024 05:22:23
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,835
            CDSs (total)                      :: 6,766
            Genes (coding)                    :: 6,456
            CDSs (with protein)               :: 6,456
            Genes (RNA)                       :: 69
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 56
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 310
            CDSs (without protein)            :: 310
            Pseudo Genes (ambiguous residues) :: 0 of 310
            Pseudo Genes (frameshifted)       :: 205 of 310
            Pseudo Genes (incomplete)         :: 185 of 310
            Pseudo Genes (internal stop)      :: 32 of 310
            Pseudo Genes (multiple problems)  :: 101 of 310
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:56:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3582586
            Orig. end                         :: 3603501
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP088109.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20915
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="8"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..20915
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20915
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10915](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10915
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    complement(27..43)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 19.45"
                     /tool="antismash"
     misc_feature    complement(36..50)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.84"
                     /tool="antismash"
     gene            complement(193..531)
                     /gene="fdxA"
                     /locus_tag="SmedWSM1115_RS18005"
                     /old_locus_tag="SmedWSM1115_18005"
     CDS             complement(193..531)
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="fdxA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003535779.1"
                     /locus_tag="SmedWSM1115_RS18005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmedWSM1115_18005"
                     /product="ferredoxin FdxA"
                     /protein_id="WP_012067320.1"
                     /transl_table=11
                     /translation="MTYVVTDNCIRCKYTDCVEVCPVDCFYEGENFLVIHPDECIDCGV
                     CEPECPAGAIKPDTEPGLDMWLKLNADFSTQWPNITVKRDPLPEATEMDGLEGKYEKYF
                     SPEPGQGD"
     misc_feature    complement(791..804)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 17.24"
                     /tool="antismash"
     gene            complement(930..1343)
                     /locus_tag="SmedWSM1115_RS18010"
                     /old_locus_tag="SmedWSM1115_18010"
     CDS             complement(930..1343)
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018209249.1"
                     /locus_tag="SmedWSM1115_RS18010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmedWSM1115_18010"
                     /product="RNA-binding S4 domain-containing protein"
                     /protein_id="WP_018209249.1"
                     /transl_table=11
                     /translation="MEKQPPSAPATRQRLDKWLFFARLIKSRSLAQKAIEAGHVAVNGK
                     RETQSSAQIKSGDMLEVSLERRDLVLRVLLPGSRRGPYEEARLLYEDLTPAAPAGKPTL
                     YEQATRDRGAGRPTKRERRETDRLRPGADHEDD"
     gene            complement(1353..4418)
                     /locus_tag="SmedWSM1115_RS18015"
                     /old_locus_tag="SmedWSM1115_18015"
     CDS             complement(1353..4418)
                     /EC_number="3.6.4.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013844928.1"
                     /locus_tag="SmedWSM1115_RS18015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmedWSM1115_18015"
                     /product="DEAD/DEAH box helicase"
                     /protein_id="WP_026183545.1"
                     /transl_table=11
                     /translation="MILSGRGVTAVLGPTNTGKTHYAIERMVAHDSGVIGLPLRLLARE
                     VYTRLVEKVGHHNVALITGEEKIAPHRARYSVCTVEAMPRETTVSFVAIDEVQLAGDLE
                     RGQIFTDRVLHLRGRGETLFLGAATMRPILEYLLPGITVVERPRMSQLLYAGSKKITRL
                     PNRSAIVAFSADEVYAIAELIRRQRGGAAVVLGALSPRTRNAQVALYQEGDVDYLVATD
                     AIGMGLNLDVDHVAFAQDRKFDGYQYRNLNPAELAQVAGRAGRHVRDGTFGVTGRVDPF
                     EEELVHRIESHEFDPVRVLQWRSKALDYSSVKALKKSLEAAPAVSGLARALPAVDQQAL
                     EHLTRYPEIVDVATTSERVEKLWEACALPDYRRITPAQHADLISSIYADLVRHGTVNEN
                     FMAEQVRRADHTDGEIDTLSARIAQIRTWTYVSNRPGWLADPTHWQEKTREIEDRLSDA
                     LHERLTKRFVDRRTSVLMKRLRENAMLEAEISVNGDVFVEGHHVGQLAGFRFTLVAGSE
                     GTDAKAVQGAAQKALALEFEARAARLHAAGNGDLALSSDGLVRWLGDPVARLTASDHVM
                     RPRVILLADEQLQANAREHVLARIERFVNHHISTVLKPLDDISRAEDLEGLAKGLAFQL
                     VENLGVLFRRDVAEEVKSLDQESRASIRRYGVRFGAYHIFLPALLKPAPAELITLLWAL
                     KNDGLDKPGYGDLIPMLAAGRTSVVTDPSFERTFYRLAGFRFLGKRAVRIDILERLADL
                     IRPLLQWKPGTSPRPEGAYDGRRFVATTSMLSILGATPDDMEEILKGLGYRADAVTAEE
                     AAAFLASQNGATPADTPAGEAAVSETDAGAQQTGEPAAEAKAASIPPAEAETRDAPAAE
                     AEAADAATSGQEVAPTSDETPAPAEPETPAESKPVLLWRPGTRQDNQRQGGRQGEQRRG
                     GQRHAQTEGREGGRRQGAQGKPPGKPREGKPQEGKGSEGRPGGQRKERGDRYDRSKPSP
                     AKFEGRPPRKEKPIDPDSPFAKLAALKEQMKK"
     misc_feature    4664..4679
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.74"
                     /tool="antismash"
     misc_feature    4823..4836
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.62"
                     /tool="antismash"
     misc_feature    4826..4841
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.74"
                     /tool="antismash"
     misc_feature    4958..4972
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 23.11"
                     /tool="antismash"
     gene            complement(5108..5833)
                     /locus_tag="SmedWSM1115_RS18020"
                     /old_locus_tag="SmedWSM1115_18020"
     CDS             complement(5108..5833)
                     /NRPS_PKS="Domain: PKS_KR (3-167). E-value: 6.5e-18. Score:
                     57.2. Matches aSDomain:
                     nrpspksdomains_SmedWSM1115_RS18020_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014766331.1"
                     /locus_tag="SmedWSM1115_RS18020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmedWSM1115_18020"
                     /product="beta-ketoacyl-ACP reductase"
                     /protein_id="WP_012067323.1"
                     /sec_met_domain="adh_short (E-value: 1.3e-36, bitscore:
                     124.2, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRVALVTGGSRGIGAAIAIALKAAGYKVAANYAGNDEKAQAFKQ
                     ETGIPVYKWDVSSYEACVDGIARVEADLGPVDILVNNAGITRDAMFHKMTPQQWGEVIG
                     TNLTGVFNMTHPIWSGMRDRGFGRIVNISSINGQKGQMGQANYSAAKAGDLGFTKALAQ
                     EGAAKGITVNAICPGYIGTEMVLAVPEKVLNERIIPQIPVGRLGEPEEVARCVVFLVSD
                     DAGFITGSTISANGGQYFA"
     aSDomain        complement(5333..5824)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SmedWSM1115_RS18020_PKS_KR.1"
                     /evalue="6.50E-18"
                     /label="SmedWSM1115_RS18020_PKS_KR.1"
                     /locus_tag="SmedWSM1115_RS18020"
                     /protein_end="167"
                     /protein_start="3"
                     /score="57.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALVTGGSRGIGAAIAIALKAAGYKVAANYAGNDEKAQAFKQETG
                     IPVYKWDVSSYEACVDGIARVEADLGPVDILVNNAGITRDAMFHKMTPQQWGEVIGTNL
                     TGVFNMTHPIWSGMRDRGFGRIVNISSINGQKGQMGQANYSAAKAGDLGFTKALAQEGA
                     A"
     CDS_motif       complement(5384..5443)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SmedWSM1115_RS18020_0001"
                     /evalue="2.40E-05"
                     /label="PKSI-KR_m4"
                     /locus_tag="SmedWSM1115_RS18020"
                     /protein_end="150"
                     /protein_start="130"
                     /score="16.8"
                     /tool="antismash"
                     /translation="NISSINGQKGQMGQANYSAA"
     gene            complement(5948..7129)
                     /locus_tag="SmedWSM1115_RS18025"
                     /old_locus_tag="SmedWSM1115_18025"
     CDS             complement(5948..7129)
                     /EC_number="2.3.1.9"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1124: acetyl-CoA acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010970528.1"
                     /locus_tag="SmedWSM1115_RS18025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmedWSM1115_18025"
                     /product="acetyl-CoA C-acetyltransferase"
                     /protein_id="WP_012067324.1"
                     /transl_table=11
                     /translation="MSNPSIVIASAARTAVGSFNGAFGNTPAHELGAAAVKAVLERAGV
                     EAGEVDEVILGQVLPAGEGQNPARQAAMKAGVPQEKTAWGMNQLCGSGLRAVALGMQQI
                     ATGDAKVIVAGGMESMSMAPHCAHLRGGVKMGDYKMIDTMIKDGLTDAFYGYHMGTTAE
                     NVARKWQLTREEQDEFALASQNKAEAAQKAGRFADEIVPFVVKTRKGDVTVDQDEYIRH
                     GATLESIAKLRPAFDKEGTVTAANASGLNDGAAAALLMTEAEAGRRGIQPLARIVSWAT
                     AGVDPQIMGTGPIPASRKALEKAGWSVAEIELVEANEAFAAQACAVNKDLGWDPSIVNV
                     NGGAIAIGHPIGASGARVLNTLLFEMKRRNVSKGLATLCIGGGMGVAMCVERL"
     misc_feature    complement(7300..7314)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.88"
                     /tool="antismash"
     gene            7352..7930
                     /gene="phaR"
                     /locus_tag="SmedWSM1115_RS18030"
                     /old_locus_tag="SmedWSM1115_18030"
     CDS             7352..7930
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="phaR"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003535770.1"
                     /locus_tag="SmedWSM1115_RS18030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmedWSM1115_18030"
                     /product="polyhydroxyalkanoate synthesis repressor PhaR"
                     /protein_id="WP_012067325.1"
                     /transl_table=11
                     /translation="MGKNEGQIVIKKYANRRLYNTGTSTYVTLDDLAVMVKRGEDFIVQ
                     DAKSGEDITHSVLTQIIFEQESKTGNTLLPISFLRQLISFYGDQMQMVVPSYLEHSMQA
                     FTEQQAQMREQITKAFGETPIGKNLKVPLQLVEEQVRRNTEMFHQAMQMFSPFMAAPAA
                     KESKKAEAKDIDELKEQLRALQTKLDNLG"
     gene            complement(8012..8197)
                     /gene="rpmF"
                     /locus_tag="SmedWSM1115_RS18035"
                     /old_locus_tag="SmedWSM1115_18035"
     CDS             complement(8012..8197)
                     /GO_component="GO:0000315 - organellar large ribosomal
                     subunit [Evidence IEA]"
                     /GO_component="GO:0022625 - cytosolic large ribosomal
                     subunit [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpmF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016556742.1"
                     /locus_tag="SmedWSM1115_RS18035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmedWSM1115_18035"
                     /product="50S ribosomal protein L32"
                     /protein_id="WP_012067326.1"
                     /transl_table=11
                     /translation="MAVPKRKTSPSKRGMRRSADALKAPTYIEDKNSGELRRPHHIDLK
                     TGMYRGRQVLTPKESA"
     misc_feature    complement(8250..8265)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.49"
                     /tool="antismash"
     gene            complement(8335..8982)
                     /locus_tag="SmedWSM1115_RS18040"
                     /old_locus_tag="SmedWSM1115_18040"
     CDS             complement(8335..8982)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GST_N_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1193: glutathione S-transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014330177.1"
                     /locus_tag="SmedWSM1115_RS18040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmedWSM1115_18040"
                     /product="glutathione S-transferase family protein"
                     /protein_id="WP_026183544.1"
                     /sec_met_domain="GST_N_3 (E-value: 3.4e-14, bitscore: 50.9,
                     seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKLVLYVGNKNYSSWSLRPWLALTASGIPFEEVVIPFDFPAGNP
                     RIREMSPTGRVPVLHHGETRVWESLAIIEYAAELFPEAGLWPDSREDRARARSYSMEML
                     SGFQALRGACPMNIRRSKKAIDLPDGVTEDVARIETIWHEQTARSGGPFLFGRFTAADA
                     MFAPVVIRFEVYDLVKDPATLAYMAAVRGHPAFRKWEEAAKVEPWIVPEDEA"
     gene            complement(9061..9849)
                     /gene="mtgA"
                     /locus_tag="SmedWSM1115_RS18045"
                     /old_locus_tag="SmedWSM1115_18045"
     CDS             complement(9061..9849)
                     /EC_number="2.4.1.129"
                     /GO_component="GO:0009274 - peptidoglycan-based cell wall
                     [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="mtgA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018013048.1"
                     /locus_tag="SmedWSM1115_RS18045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmedWSM1115_18045"
                     /product="monofunctional biosynthetic peptidoglycan
                     transglycosylase"
                     /protein_id="WP_012067328.1"
                     /transl_table=11
                     /translation="MENRADGKEVDGRGVDIISEEREEAELPAGRQTAVRRTWRARRRR
                     LVLLVLSILFLPYALIFFYLAEFIHPVSTLMLRDLVLARGYDRQWVEFDDIAPVLVQSV
                     MMSEDGQFCSHAGVDWAQMRAVVEDALDGGQTRGASTIPMQTAKNLFLWNGRSFVRKAM
                     ELPLAVAADFVWSKRRLMEIYLNVAEWGEGIYGIEAAARHHFGVSAAELSRRQAALLAV
                     SLPNPVDRNAGKPGRGLRRLASVIERRASRSGGYITCLYD"
     misc_feature    complement(9896..9908)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 19.4"
                     /tool="antismash"
     gene            10001..10915
                     /locus_tag="SmedWSM1115_RS18050"
                     /old_locus_tag="SmedWSM1115_18050"
     CDS             10001..10915
                     /EC_number="2.5.1.10"
                     /GO_function="GO:0004337 - geranyltranstransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003535760.1"
                     /locus_tag="SmedWSM1115_RS18050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmedWSM1115_18050"
                     /product="farnesyl diphosphate synthase"
                     /protein_id="WP_012067329.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.1e-54, bitscore:
                     183.4, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDERSSFPERLKSNAVAVEALLETLLDPAVRGGEISRPANLLEA
                     MRHAVLNGGKRLRPFLVSETAALLGGDVQAALRIGAALECIHCYSLVHDDLPAMDNDDM
                     RRGKPTVHVAFDEATAILAGDSLLTFSFDIIAAPETALSDRQKTALVLALARAAGHGGM
                     AGGQALDLAAEKSAPDETGIVLLQSMKTGALLRFACEAGAIIADAAAEDRQRLRAFGEK
                     IGLAFQLADDLLDLTADAAHIGKATGKDAARGKGTLVALHGQPWAEQRLESLVAEAEAL
                     LEPYGARSEVLAETARFIANRRN"
     gene            10919..11974
                     /gene="hisC"
                     /locus_tag="SmedWSM1115_RS18055"
                     /old_locus_tag="SmedWSM1115_18055"
     CDS             10919..11974
                     /EC_number="2.6.1.9"
                     /GO_function="GO:0004400 - histidinol-phosphate
                     transaminase activity [Evidence IEA]"
                     /GO_process="GO:0000105 - histidine biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (24-347). E-value:
                     3.2e-59. Score: 192.8. Matches aSDomain:
                     nrpspksdomains_SmedWSM1115_RS18055_Aminotran_1_2.1"
                     /codon_start=1
                     /gene="hisC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010970532.1"
                     /locus_tag="SmedWSM1115_RS18055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmedWSM1115_18055"
                     /product="histidinol-phosphate transaminase"
                     /protein_id="WP_018209246.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 2.3e-57, bitscore:
                     192.7, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRFWSPIVAALKPYVPGEQPRMANLVKLNTNESPYGPSEKALEA
                     IRAAADMDLRLYPDPVALGLREAIARRYGMSVGEVFVGNGSDEVLAHTFAALLKHDRPL
                     LYPDISYSFYPTYAGLFGIEAVEIPLNADFRIEIAGYRRPAGAIILPNPNAPTGIGLPL
                     SDIERLVSEHSDQPVVVDEAYIDFGGESAIALVPKYENLLVVQTFSKSRALAGLRVGFA
                     IGQRPLIEALERVKDSFNSYPLGRAALAGATAAIEDEAWFEKTRAKILATRAALTKGLE
                     ARGFEVLPSQANFVFARHQNHAGQTLAAKLRERAVIVRHFAKPRIEDFLRITIGTDDEC
                     AKLVAALDEIL"
     aSDomain        10991..11959
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SmedWSM1115_RS18055_Aminotran_1_
                     2.1"
                     /evalue="3.20E-59"
                     /label="SmedWSM1115_RS18055_Aminotran_1_2.1"
                     /locus_tag="SmedWSM1115_RS18055"
                     /protein_end="347"
                     /protein_start="24"
                     /score="192.8"
                     /tool="antismash"
                     /translation="NLVKLNTNESPYGPSEKALEAIRAAADMDLRLYPDPVALGLREAI
                     ARRYGMSVGEVFVGNGSDEVLAHTFAALLKHDRPLLYPDISYSFYPTYAGLFGIEAVEI
                     PLNADFRIEIAGYRRPAGAIILPNPNAPTGIGLPLSDIERLVSEHSDQPVVVDEAYIDF
                     GGESAIALVPKYENLLVVQTFSKSRALAGLRVGFAIGQRPLIEALERVKDSFNSYPLGR
                     AALAGATAAIEDEAWFEKTRAKILATRAALTKGLEARGFEVLPSQANFVFARHQNHAGQ
                     TLAAKLRERAVIVRHFAKPRIEDFLRITIGTDDECAKLVAAL"
     gene            complement(12037..12825)
                     /locus_tag="SmedWSM1115_RS18060"
                     /old_locus_tag="SmedWSM1115_18060"
     CDS             complement(12037..12825)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (17-136). E-value: 2.8e-11.
                     Score: 35.6. Matches aSDomain:
                     nrpspksdomains_SmedWSM1115_RS18060_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020050238.1"
                     /locus_tag="SmedWSM1115_RS18060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmedWSM1115_18060"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_018209245.1"
                     /sec_met_domain="adh_short (E-value: 1.5e-31, bitscore:
                     107.7, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEISLDAPKLFDLAGNVALVTGAGSGIGQRIAIGLAQCGADVGL
                     LDRRTDDGLAKTADLIEKAGRRSIQIAADVTSGAALDEAVARTEAELGPLTLALNAAGI
                     ANAHPAEEMEETQFQTMMDVNLKGVFLSCQAEARAMLRNGRGSIVNIASMSGVIVNRGL
                     NQCHYNASKAGVIHMSKSMAMEWVGRGIRVNTISPGYTATPMNTRPEMVHQSRLFEEQT
                     PMQRMAGVDEMVGPAVFLLSDAASFVTGVDLLVDGGFCCW"
     aSDomain        complement(12418..12774)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SmedWSM1115_RS18060_PKS_KR.1"
                     /evalue="2.80E-11"
                     /label="SmedWSM1115_RS18060_PKS_KR.1"
                     /locus_tag="SmedWSM1115_RS18060"
                     /protein_end="136"
                     /protein_start="17"
                     /score="35.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VALVTGAGSGIGQRIAIGLAQCGADVGLLDRRTDDGLAKTADLIE
                     KAGRRSIQIAADVTSGAALDEAVARTEAELGPLTLALNAAGIANAHPAEEMEETQFQTM
                     MDVNLKGVFLSCQAE"
     CDS_motif       complement(12703..12768)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SmedWSM1115_RS18060_0001"
                     /evalue="6.10E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="SmedWSM1115_RS18060"
                     /protein_end="41"
                     /protein_start="19"
                     /score="12.5"
                     /tool="antismash"
                     /translation="LVTGAGSGIGQRIAIGLAQCGA"
     misc_feature    12789..12805
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: strong, score: 25.77"
                     /tool="antismash"
     gene            complement(12842..14329)
                     /locus_tag="SmedWSM1115_RS18065"
                     /old_locus_tag="SmedWSM1115_18065"
     CDS             complement(12842..14329)
                     /EC_number="7.5.2.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003579720.1"
                     /locus_tag="SmedWSM1115_RS18065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmedWSM1115_18065"
                     /product="sugar ABC transporter ATP-binding protein"
                     /protein_id="WP_012067332.1"
                     /transl_table=11
                     /translation="MTPHSPILSLRRIRKSYGPIKVLHGIDLDIHPGEVVALLGENGAG
                     KSTLSNIISGTVQPSAGEMTWLGRAYAPADPRAAMEEGIGMIHQELKLLPKLSIAENVF
                     VGRYPMKAGRIDRKTMEDRARSGLHRLGLDISPDRLVDGLSTGKQQLIEIAKALTLNAR
                     LLILDEPTAALGAEETQLLFRQIERLKSEGVGIIYISHRLEEIRKIADRIVVMRDGAKV
                     QEFESGDVPIRTIVEAMVGRSLERMFPTLPAPTDQVTLEVRNLSSPSNAFRDISFSVRR
                     GEVFGIAGLMGAGRTELVRAISGADPISSGEVLLHGRPVTPRSPIDAIRNGIVLVPEDR
                     KLQGVVLDHSIAENIGYANLGEISRSGWVSSRRIRQFAEECIKTFGVKGRGGQNAGELS
                     GGNQQKVVLAKWLARKPQVVVLDEPTRGIDVGARSSIYDLIIDLAREGVAVIVVSSDLE
                     EVLGVSSRILVMAQGKQAGILNREDANDVSVMELATI"
     gene            complement(14356..15288)
                     /locus_tag="SmedWSM1115_RS18070"
                     /old_locus_tag="SmedWSM1115_18070"
     CDS             complement(14356..15288)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1205: ABC
                     transporter, carbohydrate uptake"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012067333.1"
                     /locus_tag="SmedWSM1115_RS18070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmedWSM1115_18070"
                     /product="substrate-binding domain-containing protein"
                     /protein_id="WP_018209244.1"
                     /transl_table=11
                     /translation="MKLSTLLVAATTASVLALPASAAEIKKIGLAVPNLQADFFNQIKL
                     GVEKHAREKGLEVVVVDAKNDTNTQVSQVQDLMIQDIDAFIYIPAGAAAAAVPTRLARE
                     AGIPVINVDRVPEGAPGDTFIAGESVESAYAVCKFIIEKAGGSGKMAIIHGQKGTTPEV
                     DRFTGCKRAIDENKGVELIDQQWSNMWSADEGFSIAQNMLQANPDITIIFGQADGLAMG
                     AAKAVDVANLSDKVIIGGYDGDVSALEYLARCKGPFIATATQSTQKMGVLAVESALAVA
                     AGEKVEERQTPNAVLTTCDNAPEFVKNHP"
     gene            complement(15414..16388)
                     /locus_tag="SmedWSM1115_RS18075"
                     /old_locus_tag="SmedWSM1115_18075"
     CDS             complement(15414..16388)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1113:
                     inner-membrane translocator"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012067334.1"
                     /locus_tag="SmedWSM1115_RS18075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmedWSM1115_18075"
                     /product="ABC transporter permease"
                     /protein_id="WP_018209243.1"
                     /transl_table=11
                     /translation="MRAAVQDKQGAAVRLLPSLKGATGPLIGLIVLCLFLTFATDKFLS
                     VRNFLNVLDQITVLGVMAVGMTFVILIGGIDLAVGSVMALAMMVLGYLHVVAGVPMWLA
                     IPLALAAAALNGLIAGLLITRFNVPAFIATLAMMSITRGLANMVTDGQQIIGFPAWFNM
                     MAIVRFGGFLTLTVAVMIVVFIVGLLYQRYRHGGRVLYAVGGNAEVARLAGIDVQRATV
                     LVYVVCSFLAGLSGMVLAARLDSVQPSSGVSYELDAIAAVVIGGTSLSGGTGGIGGTII
                     GVLIIGVLRNGLNLLSVSPFMQQVIIGAVIVLAVTAETYRKRK"
     misc_feature    complement(16425..16438)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 16.76"
                     /tool="antismash"
     misc_feature    complement(16569..16584)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.27"
                     /tool="antismash"
     misc_feature    16572..16592
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.42"
                     /tool="antismash"
     gene            16594..17403
                     /locus_tag="SmedWSM1115_RS18080"
                     /old_locus_tag="SmedWSM1115_18080"
     CDS             16594..17403
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DXP_synthase_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1204: transketolase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011652254.1"
                     /locus_tag="SmedWSM1115_RS18080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmedWSM1115_18080"
                     /product="transketolase"
                     /protein_id="WP_024310901.1"
                     /sec_met_domain="DXP_synthase_N (E-value: 2.8e-10,
                     bitscore: 37.7, seeds: 174, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.5e-06, bitscore:
                     25.2, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQPNDLDRIAQQIRLRDLQAVFEAGAGHIGGEMSAIDILTALYFR
                     VLRIWPEQPKHPDRDRFVLSKGHVALALYVTLAKRGFIPEEEIGTFLKPHSRLNGHPNC
                     TKVPGIETNTGPLGHGLPVAVGMAKAAKLTRAKYHTYALTGDGEMQEGSNWEAISSAAQ
                     FGLDNLTLIIDHNRFQQGAALKDTNNLAPFPAKLEAFGWDVTEINGNAMDEVVPALEKR
                     GSRPHCIVAHTNKGHGISFMQDKVDWHHKVPNDEQYKIAVAELSEAL"
     gene            17403..18371
                     /locus_tag="SmedWSM1115_RS18085"
                     /old_locus_tag="SmedWSM1115_18085"
     CDS             17403..18371
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012067336.1"
                     /locus_tag="SmedWSM1115_RS18085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmedWSM1115_18085"
                     /product="transketolase family protein"
                     /protein_id="WP_012067336.1"
                     /transl_table=11
                     /translation="MNAVTSSAKLHDCRDAFVTVLERLSADNPRIVAVCNDSVGSSKLG
                     GFRARWPDRLVNVGIAEQNMVGVGAGLANGGLLPFVCGAACFLTGRSLEQIKADIAYSN
                     ANVKLIGISSGMAYGELGPTHHSIEDFAWTRVLPNLPVIAPCDSVETAAAVEWAAHYDG
                     PVFLRLSRVGVPDLLPSGHTFELGKANLLRDGDAITLVANGTVTHRILKAADLLAAEGI
                     EARVLNMATVRPLDLDAVVAAARETGAILTAEEHSTFGGLGSAVAELVVAEAPVPMKIL
                     GVPGIFAPTGSAEFLLDEFGMSPAAIAEAAVALIARKPSRA"
     gene            18446..19915
                     /locus_tag="SmedWSM1115_RS18090"
                     /old_locus_tag="SmedWSM1115_18090"
     CDS             18446..19915
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0019200 - carbohydrate kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1210: glycerol kinase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012067337.1"
                     /locus_tag="SmedWSM1115_RS18090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmedWSM1115_18090"
                     /product="FGGY-family carbohydrate kinase"
                     /protein_id="WP_018209241.1"
                     /transl_table=11
                     /translation="MTTAILAIDQGTTNSKAVLVSTTGEILSRGASPVGIEHPQPGWVE
                     QNPLRIWESVQEAIAACLQKGPRSDILGIAISNQRESVTAWDAATGKPLGPVVSWQCRR
                     SAPACAELSAAGHAERVRALTGLPIDPMFPGPKMRWLLDRIPPGHEVRLGTIDAWLIHC
                     FTAGAIHACDAGNAARSQLYDLNRRAWSDELCDLFGVPKSALPEVCDSAARFGVTKNVP
                     GLKDGIPIASAIGDSHAALFGHGAFNPGDGKVTFGTGSSIMTTLPRFIAPEQGITTTIA
                     WSIAGRPTYAFEGNILVSAAALPWMAEMLGLSHVEDLIDLAATAEPRGPGFVPAFVGLG
                     APYWHADARALFSGITFNTTRAQMARAVTDSMAFQVHDVFKAMSAQSPTPLGRLYADGG
                     PSKNTFLMQCVADTLNHVITQCDAPEASALGAAYLAGLSLGVWPDLAAVASLPRAGKPV
                     LPRPCDAADRLMVWQDAIYRSTVPGPSIMSE"
     gene            19939..20889
                     /locus_tag="SmedWSM1115_RS18095"
                     /old_locus_tag="SmedWSM1115_18095"
     CDS             19939..20889
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0030246 - carbohydrate binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014989283.1"
                     /locus_tag="SmedWSM1115_RS18095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SmedWSM1115_18095"
                     /product="sugar-binding transcriptional regulator"
                     /protein_id="WP_012067338.1"
                     /transl_table=11
                     /translation="MGRLNELRLIARVAQMYHIESKRQAEIAEIMHMSQATVSRMLKRA
                     EQEDIVRTTVIPPAGTFADLETALRERYGLTEAIVIDCSEDRDGAIMARIGEAAAHFLE
                     VTLQQDEIVGVSSWSQTILRMVDNIHPLKNAKAKYIVQILGGMGDASVQTHATQLTARL
                     ARLTGGEPRLLLVQGITSSREAKLVMLADPVVRETMDLFGRLSLAIIGIGAVEPSELLA
                     RSGNTFSRQEMAMLHEAGAVGEISYRFYDKGGKPVETPLNDRVIGISLEDLRKTGRVMA
                     LAGGESKTQAIAGALRLGVIDVLVTDKFTAARLTA"
ORIGIN
        1 cgcgcaaaag caccctctgt ggatcagtgt aagaaaacta tcacaaaaaa gagcggaaat
       61 caataatttg ctgcacggca acgatcaagt cgccgcgctc gcaagcgcga agtgccggtg
      121 ggattttccc cagctttccg gccttgccat ctgtcgtccg cctgtacgac gctccagcgc
      181 cgcagagccg cctcagtcgc cctgtcccgg ctccggagaa aaatacttct cgtactttcc
      241 ttccaggccg tccatctccg tagcctccgg cagcggatcc cgcttgacgg tgatattcgg
      301 ccattgcgtg gagaaatctg cgttaagctt caaccacata tccagacccg gctcggtatc
      361 cggcttgatc gccccagcgg gacattccgg ctcgcatacg ccgcagtcga tgcattcatc
      421 cggatggatg acgaggaagt tctccccctc ataaaaacaa tccaccgggc agacttcgac
      481 gcagtccgtg tacttacagc gaatgcagtt atcggtcacg acatacgtca tgaggtactc
      541 cagccaatgc tcacatttga tggcagacgg caatcaacgg tgacactcga tcgcccgcgc
      601 atgctaggaa tgtccggagc gcatagctgc cgaagcagtc ctgaatgcca tcctccgcat
      661 ggcttcgtga atcgggaacg atccaggggt gaaaccacgc atcggttcaa cctgctacac
      721 ctgccgtcgc cccgaaaaaa tgggcccggc gctgcagcgt tgcttgtgac gtaaaggctt
      781 tgacggccct ttgcaagaat tatccatgcg cgatttgccc ctatgggggc acagttttcc
      841 agcctcggga ccggcgtgcc gaattccgtt gcagggcacc tgaaaggaag ggcaatcggg
      901 cgtcccgacg gtgcccggcg cgacgaaact caatcgtcct cgtggtccgc gcccggccgc
      961 agccggtcgg tttcgcgacg ctcccgcttc gtcggccgcc ctgctccgcg gtctcgcgtc
     1021 gcctgctcgt aaagcgtggg cttgccggcg ggcgcggcgg gcgtgagatc ctcgtaaagc
     1081 agacgggctt cctcgtaggg ccctcggcgg gacccaggca gcagcacccg caagaccaga
     1141 tcgcgccgct ccagcgacac ttcgagcatg tctccggact ttatctgggc ggacgattgc
     1201 gtttcacgtt tgccgttgac cgccacgtga ccggcctcga tcgccttctg agcgagcgag
     1261 cgcgatttga tcagccgggc aaagaacagc catttgtcga gccgctgacg cgttgcaggg
     1321 gcggacggcg gctgtttttc catggcccga acctatttct tcatctgctc cttcagagca
     1381 gccagcttgg cgaaaggtga atccggatcg atcggcttct ccttgcgtgg cgggcgcccc
     1441 tcgaacttgg cgggagacgg cttgctgcga tcgtaccggt cgccccgctc cttgcgctgt
     1501 ccgcccggcc ttccttccga acccttgccc tcctgaggct tgccttccct cggcttgcct
     1561 ggcggcttgc cctgggcgcc ctgcctgcgg ccgccctcgc gtccctcggt ctgggcatgc
     1621 cgctgtccac cgcggcgctg ttcgccttgg cgaccgcctt gccgctgatt gtcctgacgc
     1681 gtgccgggcc gccacaggag caccggcttg gattcagccg gcgtctcagg ctcggccggc
     1741 gccggtgttt cgtcgctggt cggcgcgact tcctgcccgc tggtcgcagc atcggccgct
     1801 tccgcttccg cggccggtgc atcgcgcgtc tcagcctctg ctggcggtat gctggccgct
     1861 ttggcctctg cagccggttc accggtctgt tgagccccgg catccgtttc gctcacggcg
     1921 gcttctccgg caggtgtgtc cgccggggta gcgccgttct gacttgccag gaatgcggcc
     1981 gcctcttcgg cggtcacggc gtcggcacga tagccgagcc ccttgaggat ctcctccatg
     2041 tcgtcaggcg ttgccccgag tatggacagc atcgatgtcg tcgccacgaa acggcggccg
     2101 tcataggcgc cctcgggacg cggcgacgtc cccggcttcc actggagaag cggacggatg
     2161 agatcggcaa gccgctcgag tatatcgatg cgcaccgcgc gcttgccgag gaatcggaag
     2221 cccgcgagcc tgtagaaggt ccgctcgaag gaagggtcgg tgacgacgga ggtccgccca
     2281 gcagcgagca tcgggatgag gtcgccgtag cccggcttgt cgagcccatc gtttttcagc
     2341 gcccagagca gcgtgatcag ctccgccgga gcgggtttca aaagcgcggg gaggaagatg
     2401 tgataggctc cgaagcgaac accgtatctg cggatagatg cacggctctc ctgatcgagc
     2461 gacttcacct cttctgcaac gtcgcgacgg aagagcacgc cgaggttttc gacgagctgg
     2521 aaggcaagcc ctttggcaag cccctccagg tcctcggcgc gcgagatatc gtccagcggc
     2581 ttcagcaccg tgctgatgtg atgatttacg aagcgctcga tccgagcgag tacatgctcg
     2641 cgcgcattgg cctggagctg ctcgtcggca agcaggatca cccggggacg catgacatgg
     2701 tcgctcgccg tgagccgcgc gaccggatcc ccgagccaac ggacgagacc gtccgacgac
     2761 agggccagat cgccattacc ggccgcgtgg agacgggcgg cgcgcgcttc gaattccagc
     2821 gcgagcgcct tctgggcggc gccctgcacg gccttcgcgt ccgttccctc gctgcccgca
     2881 acgagcgtga accggaaacc ggctagctga cccacatggt gtccctcgac gaagacatca
     2941 ccattcacac tgatttctgc ttccagcatc gcattctctc tcaggcgctt catgagcaca
     3001 gatgtcctgc gatcaacaaa gcgtttcgtc aaccgttcat gtagcgcgtc ggacaatcga
     3061 tcttcgattt cccgcgtctt ttcttgccag tgtgtcggat cggcaagcca cccgggccga
     3121 ttggacacat aggtccaggt cctgatctgc gcaattcgcg ccgaaagtgt gtcgatttcc
     3181 ccgtccgtgt gatcggcacg ccggacctgt tcggccatga aattctcatt gaccgtccca
     3241 tggcgaacga ggtcggcata gatactcgag atcagatccg catgctgggc gggcgtaatg
     3301 cggcggtagt ccgggagtgc gcaggcttcc cacagcttct ccacgcgctc ggacgtcgtc
     3361 gctacgtcga cgatctccgg gtagcgcgtc agatgctcga gagcctgctg atcgacggcc
     3421 gggagcgccc gcgccaaccc ggagaccgcc ggtgccgcct ccaggctttt cttcagcgcc
     3481 ttcactgaag aataatccag cgccttggag cgccattgca gcacccggac ggggtcgaac
     3541 tcatgcgatt cgatccggtg aacaagctcc tcctcgaaag ggtcgacgcg gcccgtgacg
     3601 ccaaacgtcc cgtcccggac gtgcctgccc gcgcgccccg ccacctgcgc gagctccgcc
     3661 ggattgaggt tgcgatattg ataaccgtcg aacttccggt cctgggcgaa ggccacgtgg
     3721 tcgacgtcga ggttcagccc catgccgatc gcatcggttg ccacgagata atcgacgtct
     3781 ccctcctggt agagggccac ctgggcattg cgggtccgcg gcgaaagagc gcccagaacg
     3841 acggccgccc cgccgcgctg ccgccggatg agctctgcta tcgcatagac ctcgtcggcc
     3901 gaaaaggcga cgattgcgga gcggttcggc aggcgcgtga tctttttgga tccggcatag
     3961 agaagctgcg acatacgcgg ccgttcgacc acggtgatgc cgggcagaag atattcgaga
     4021 atgggccgca tcgtcgcagc cccgaggaac agcgtctcgc cgcgaccgcg aaggtgcagg
     4081 accctgtccg tgaagatttg accgcgttcg agatcgcctg cgagctggac ctcgtcgatc
     4141 gccacgaaag agaccgtcgt ctcgcgcggc atcgcctcca ccgtgcagac cgagtaccgg
     4201 gcccggtggg gcgcgatctt ttcctcgccc gttatcagcg cgacattatg atggccgacc
     4261 ttctccacca ggcgcgtata gacctcacgc gcgagcaatc tcagcggcag cccgatgacg
     4321 ccgctgtcat gcgcgaccat gcgctcgata gcataatggg tcttgccggt attggtaggc
     4381 ccgagcaccg cggttacacc gcggccgctc aggatcatgg attgaaagga caagatctcg
     4441 atcccaggca gtctttgcag cgccgcacgt ttttcagacg cacgaagggc tttcaccttc
     4501 cggcgggaaa cagatgccca tgcgacgcgc cgaacgcaag ggttcatgga caataaaaac
     4561 tcaaaagcgc ccaaccatat cttgcgcctc acgtagaact tgcggctcaa gattccggaa
     4621 cagcgccgga acgaatcagc gacgaatcgc tgactctctc tgattcactc tatgttcacg
     4681 gctatatatg ggcttcaaca tctagttacg caccatatgc tgaatccggg caagaaacat
     4741 acgtcgaaag gtcccaagcg gcctcttcat ttcgcagcat tgctctgaac cgcgcaaagg
     4801 attccgaatc caagagattg gaatgattga aaaaaattaa cgggattcac gaggccggcg
     4861 cgcgaatccg ggaataggaa tcgcttcgcg ggtattcggc ttttgccggg cagttcgctc
     4921 gcaactcgtc ggcacggcca ttttcccctt tcgttcacca caacatgtag agccggatga
     4981 ggaacactgc gtgcggtctc ctgaggccga tccaacccaa aaaaccgtgg tccagccgcc
     5041 gaatgcccgt cgaaaaaaat ccggcgccgc aaagggcggc gggaacacag tcggtcagaa
     5101 aaaagtctca ggcgaagtac tggccaccat tggccgagat cgtggaaccg gtaatgaagc
     5161 cggcatcatc cgacacgagg aacacgacgc atcgcgcgac ttcttccggt tcgcccaggc
     5221 ggccgacggg tatctgcggg atgatccgct cgttaagcac cttctccggt acggcgagca
     5281 ccatttccgt gccgatataa cccgggcaaa tggcatttac cgtgattccc ttcgctgccc
     5341 cttcctgagc aagcgccttg gtgaagccga gatcgccggc cttggcggca gaatagttcg
     5401 cctgtcccat ctgccccttc tgaccgttga tcgacgagat gttgacgatg cggccgaacc
     5461 cgcggtcgcg catccccgac cagatcggat gcgtcatgtt gaaaacgccg gtgagattcg
     5521 tgcctatgac ttcgccccat tgttgcggcg tcatcttgtg gaacatcgcg tcacgtgtga
     5581 tgccggcatt gttgacgagg atatctaccg gccccaggtc cgcctcgacc ctggcaatgc
     5641 cgtcgacgca ggcctcgtaa ctcgagacat cccacttata aacggggatg ccggtctcct
     5701 gtttgaaagc ctgggctttt tcgtcattgc ccgcgtaatt cgcagccacc ttgtagcccg
     5761 ctgccttcag cgcgatggcg attgccgcgc cgatgccgcg cgatccgccc gtgaccaatg
     5821 ctaccctgct cattagtgcc tcccgctctg ttaagccaaa ttggcgaaaa tcgtccttcc
     5881 gcggcccgga gcccgggccg cctgtgcata tccggatctg gaagtcgccc ggctcaccgg
     5941 gcgtcggcta aaggcgttcc acgcacatgg cgacccccat gccgccgccg atgcagagtg
     6001 tcgcaaggcc cttcgagacg ttgcgccgct tcatttcaaa aagaagcgtg ttcagcacgc
     6061 gggctccgga cgcgccgatc ggatgtccga tggcgatcgc gccgccattg acgttgacga
     6121 tcgacgggtc ccaaccgaga tccttgttga cggcgcatgc ctgggccgcg aaggcctcgt
     6181 tggcctctac gagttcaatt tcggcgaccg accagccggc tttttcaagt gccttgcgcg
     6241 atgcggggat cgggcccgtg cccatgatct gcgggtcgac gcccgccgtg gcccaggaga
     6301 cgatgcgggc aagcggctgg atgccgcgcc ggccggcctc ggcctcggtc atcagcagag
     6361 cggcggcggc gccgtcattg aggcccgacg cgttggcggc agtgacggtg ccttccttgt
     6421 cgaaagccgg gcgaagcttc gcaatcgatt ccagcgtggc gccgtgacgt atgtattcgt
     6481 cctggtcgac agtgacgtcg cctttccgcg tcttgacgac gaaaggaacg atctcgtcgg
     6541 cgaagcggcc ggctttctgg gcggcttcgg ccttgttctg ggaggccagc gcgaattcgt
     6601 cctgctcctc gcgcgtaagc tgccatttcc gcgcgacgtt ctccgcggta gtgcccatgt
     6661 gatatccata gaaggcgtcc gtcaggccgt ccttgatcat cgtgtcgatc atcttgtaat
     6721 cgcccatttt cacgccgccc cgcaagtgcg cgcaatgcgg cgccatggac atcgactcca
     6781 tgccgccggc gacgatgacc ttcgcatcac cggttgcgat ctgctgcatg ccgagcgcca
     6841 cggcgcgcag gccggagccg cagagctgat tcatgcccca ggcggtcttt tcctgcggga
     6901 ctccggcttt catcgccgcc tggcgcgccg gattctgccc ctcgcccgcc ggcagcacct
     6961 gcccgaggat cacctcgtcc acttcgccgg cttcgacacc ggcccgctcc agaaccgcct
     7021 tgaccgcggc cgcgcccaat tcgtgcgcag gcgtattgcc gaaggcgcca ttgaaggagc
     7081 cgacggccgt gcgggcggcg ctggcgatga cgatcgaggg attgctcatg ggacgttcct
     7141 catatttgct ttgcctgatg gaggcagact ggcaaaggga ggggcgcaag tcaaacggcg
     7201 agttgcactg ccgcaaaagc ttcaggaggg cttgccgacg cttgttcgca cctgcgtcgc
     7261 cgcattgcac aaagagattg tcagtggcgc tcttttgcgg atactctgaa aagtacaata
     7321 aagacgggac gatgggtaag aggagaccct gatggggaaa aacgaaggcc agatcgttat
     7381 caagaaatat gcgaaccggc ggctctacaa caccggtacg agcacgtacg taaccctcga
     7441 tgacctggct gtcatggtga agaggggcga ggacttcatc gtacaggacg caaagtccgg
     7501 cgaagatata acccattccg tgctgacgca gattatcttc gagcaggagt cgaaaaccgg
     7561 taacacgctc ctgccgattt cctttctccg ccagttgatc tccttttatg gcgaccagat
     7621 gcagatggtc gtgccgagct atctcgaaca ctcgatgcag gctttcaccg aacagcaggc
     7681 tcagatgcgc gagcagatca ccaaggcctt cggtgagacg ccgatcggca agaacctcaa
     7741 agtgccgctg caactggtcg aggaacaggt ccggcgcaac accgaaatgt tccatcaggc
     7801 catgcagatg ttctcgccct tcatggcggc cccagccgca aaggaaagca agaaggccga
     7861 agcgaaagac atcgacgaat tgaaagaaca gcttcgagcc ctccagacga agctggataa
     7921 tctcggctga ctttcaggcg ttcggagccg taccaaagaa aaagggccgg caatgccgac
     7981 ccttcgaatt tcatccgcga gtgatatgcg cttatgcgct ttccttcggc gtcagaacct
     8041 ggcggccgcg atacatgccg gtcttcaggt cgatgtgatg cgggcggcgc agttcgccgg
     8101 aattcttgtc ttcgatgtag gtcggagcct tgagggcgtc agcggaacgg cgcatgccac
     8161 gcttggacgg gctcgttttt cttttcggta cagccatttc attctccact tatcgggcaa
     8221 aacactgttc agcagccgaa aatggccggg tcaaacagat gtcgatctcg gaatttcgcg
     8281 cgcttataca tgccggaccg cagtttgacc agtccccgcg cacaaatttt cgattcaggc
     8341 ttcatcctcc ggaacgatcc agggctcgac tttcgcggcc tcttcccact tgcggaaggc
     8401 cggatgccct cggacggccg ccatataggc aagcgtcgcc ggatctttca cgaggtcata
     8461 gacttcgaag cggatgacga caggtgcgaa catggcatcc gcggcggtga accggccaaa
     8521 gaggaacgga ccgccagacc gcgcggtttg ctcgtgccag atcgtctcga tccgcgccac
     8581 atcctcggta acgccgtcgg gcagatcgat cgccttcttc gaccggcgga tgttcatggg
     8641 gcaggcgccg cgcagtgcct ggaagccgga gagcatctcc atcgaatagc tccgcgcgcg
     8701 tgcgcgatcc tcgcggctat cgggccagag gccagcctcc ggaaagagct ccgccgcata
     8761 ttcgataatg gcgagcgatt cccacacgcg ggtttcgcca tgatggagta ccggaacacg
     8821 tcctgtcggc gacatctcgc ggatgcgggg gttgccggcg ggaaagtcga agggaatgac
     8881 gacctcttcg aacggaatgc cgctggccgt gagtgccagc catggccgga gcgaccagga
     8941 cgaatagttc ttgttgccga catagaggac gagcttggcc atgatttttg tctccgcctg
     9001 aagttccgga cggcagcctt gccacatcaa aggccgacag accaatgaat tggattcatc
     9061 tcaatcataa agacacgtga tatagccgcc ggagcggctt gcccggcgct cgatcaccga
     9121 ggcgagacgc cgcagaccgc gccccggttt gccggcgttg cggtcgaccg gatttggcag
     9181 cgatacggcg agaagagcag cctgacggcg cgagagctcc gccgccgaaa cgccgaaatg
     9241 atgccgggct gcagcttcga tcccgtaaat gccctcgccc cattcggcga cgttcagata
     9301 aatctccatc aggcgccgtt tgctccagac gaaatcggcg gcgaccgcga gcggcagctc
     9361 catcgctttg cgcacgaagg aacggccatt ccagaggaac aggttcttgg cggtctgcat
     9421 cgggatcgta ctggcgccgc gcgtctgtcc gccgtcgagc gcatcctcta cgacggcgcg
     9481 catctgagcc caatcgacgc cggcatgcga gcagaactgc ccgtcctccg acatcattac
     9541 cgactggacg agcaccggcg cgatgtcgtc gaactcgacc cattgccggt catagccgcg
     9601 cgccagcacg aggtcgcgca gcatcagggt agagaccggg tgaatgaact cggcgagata
     9661 gaagaagatc agcgcgtagg gcaggaacag gatggagagc acgagtagaa cgaggcggcg
     9721 acgacgcgca cgccacgtcc gtcgcacggc cgtctgccgg ccggcgggca attccgcttc
     9781 ctcgcgctct tccgaaatga tgtccacgcc ccgcccgtcc acctctttcc cgtccgcccg
     9841 gttttccatc cacctccctc atatgccatg gcgagccaaa gttgaacggc ctttctggca
     9901 aaaggcaagg ctcagaaggt gcatcatcac cgacaggctg tgcgcgctgc gacgtgaaag
     9961 cccgttgaaa gccgctccgc cgcatgccaa agagccttgt atgacagacg aaagatcatc
    10021 ctttccagag cgcctcaagt ccaatgcggt cgcggtcgaa gcgctgctcg agacattgct
    10081 cgacccagcc gtgcgtggcg gcgaaatttc ccgccctgcg aacctgctcg aagccatgcg
    10141 tcatgcggtg ctcaatggcg gcaagcggct gcggcccttt cttgtcagcg aaactgcggc
    10201 gctcctcggc ggcgatgtgc aagcggcact gagaattggc gctgcgctcg aatgcattca
    10261 ttgctactcg cttgtccatg acgatctgcc ggcgatggac aacgacgaca tgcggcgcgg
    10321 aaaaccgacg gtgcacgtcg ccttcgacga ggcaaccgcg atcctcgcgg gcgatagcct
    10381 gctgaccttc tccttcgaca tcatcgcggc gccggagaca gccctttccg atcgccagaa
    10441 gaccgcgctc gtgctggcgc tcgcacgggc ggcagggcac gggggcatgg ctggggggca
    10501 ggcactcgac cttgccgccg aaaagagcgc ccccgatgag acgggcatcg tactcctgca
    10561 atcgatgaag accggcgcgc ttctccgctt cgcctgcgag gcgggcgcga tcatcgcgga
    10621 tgcggcggcc gaggaccgcc agcgtctgcg ggccttcgga gagaagatcg gcctcgcctt
    10681 ccagcttgcg gacgatctgc tcgacctcac cgccgacgcc gcgcacatag gcaaggcaac
    10741 cggaaaggat gccgcgcgag gaaagggtac actcgtcgcg ctgcacggac agccctgggc
    10801 cgagcagcgg ctcgaaagcc tggtggccga agcggaagcg ctccttgagc cttatggcgc
    10861 ccgttcggag gtccttgccg agaccgctcg tttcattgcc aaccgcagga actgatagat
    10921 gagcagattc tggtcgccga tcgttgccgc cttgaagcct tacgttcccg gtgaacagcc
    10981 gcggatggcg aacctcgtca agctcaacac caatgagagc ccctatggcc cctcggaaaa
    11041 agcgctggag gcgattcggg cggcggcgga catggatctc aggctttatc cggatcccgt
    11101 cgctctcggg ttgcgggagg cgatcgctag gcgctacggc atgtccgtcg gcgaggtctt
    11161 cgtcggcaat ggttccgacg aggttctggc ccacaccttc gcggcgcttt tgaaacacga
    11221 tcggccgctg ctttatcctg acatctccta cagcttctat ccgacctatg cgggcctttt
    11281 cggcatcgaa gcggtcgaga ttccgctgaa cgccgacttc cgcatcgaaa ttgcaggcta
    11341 tcgccgccct gccggcgcca tcatcctgcc gaatccgaat gcgccgacgg gaatcggcct
    11401 gccgctttcc gacattgaaa ggctggtgag cgagcattcc gaccagcccg tggtcgtcga
    11461 cgaggcctat atcgacttcg gcggcgaatc cgcgatcgca ctcgttccga aatacgagaa
    11521 cctgctcgtc gttcagacct tctcgaagtc acgtgcgctt gccggtcttc gcgtcggctt
    11581 cgcgataggc caaaggccgc tgatcgaggc gttggagcgc gtcaaggata gtttcaattc
    11641 ctatccgctc gggcgcgccg cccttgcggg tgcaacggct gcgatcgagg acgaggcctg
    11701 gttcgagaag acgcgcgcca agatcctcgc cacgcgggcg gcattgacga aggggctcga
    11761 agcgcgcggt ttcgaggtcc tgccgtctca ggcgaatttc gtcttcgccc ggcatcagaa
    11821 ccacgcgggc cagacgctgg cggcgaaact ccgcgaacgc gcggtcatcg tccgccattt
    11881 tgccaagccc cggattgagg atttcctgcg catcaccatc ggcacagatg atgaatgcgc
    11941 caaactggtc gcggcgctcg acgaaattct gtgagatcgc aggtcagatt gaagcggcac
    12001 cggcgagatt gcggcgccgc ctcctgaccg gcgatatcac cagcagcaga agccgccatc
    12061 aacgagaagg tctactccgg ttacgaagct cgccgcatcc gacagaagga aaacggccgg
    12121 gccgaccatt tcgtccacgc cagccatgcg ctgcatcggc gtctgttcct cgaagagcct
    12181 ggactggtgc accatttccg gtctagtatt cataggtgtt gccgtatagc ccggactgat
    12241 ggtgttgacc cggatgccgc ggcctaccca ctccatcgcc atggacttcg acatgtgaat
    12301 tacacccgcc ttagaggcgt tgtagtggca ctggttaagt cctcgattca cgatgacgcc
    12361 ggacatcgag gcgatgttga cgatcgaccc gcgtccgttc ctcaacatgg cgcgcgcttc
    12421 cgcctggcag gagaggaaaa cgcctttcag attgacgtcc atcatcgtct ggaactgagt
    12481 ttcctccatc tcctccgccg gatgagcatt ggcgatgccc gcggcgttga gcgcgagggt
    12541 cagcgggccc agctccgctt ctgtgcgcgc aaccgcctcg tcgagcgccg cgccgctggt
    12601 gacatcagcg gcgatctgaa tgctgcgacg cccagccttt tcgatgagat cggccgtctt
    12661 cgcgagacca tcatcggtcc gtcggtctag taacccgaca tctgcgccgc actgtgcgag
    12721 accgatggcg atgcgttggc cgatgccgct gcccgcgccg gtcacgaggg cgacgtttcc
    12781 ggcaagatcg aacaatttcg gtgcgtcaag actgatttca gacatatggg ttctttcctg
    12841 cttagatcgt tgccagttcc atgacagaga cgtcgttcgc atcctcgcgg ttcaggatgc
    12901 cggcctgctt gccctgcgcc atgaccagga tgcggctgga gacgccgagc acctcttcga
    12961 gatccgagct gaccacgatg actgcgacgc cctcgcgggc gagatcgatg atgagatcgt
    13021 agatcgacga gcgggcgcct acgtcgatgc cgcgcgtcgg ctcgtccagc acgaccacct
    13081 gcggttttcg cgccagccat ttggcgagca ccactttctg ctggttgccg ccggaaagct
    13141 ccccggcatt ctgccccccg cggcctttta ctccgaacgt cttgatgcac tcctcggcga
    13201 actgccggat gcggcgcgag gagacccagc cgctgcggga gatttcgccg aggttggcat
    13261 agccgatatt ttccgcgatc gaatgatcga gcacgacgcc ctggagcttt cgatcctccg
    13321 gcacgagaac gatgccgttg cggatcgcat cgatcggaga gcggggcgtg acgggcctgc
    13381 cgtgcagcag gacttcgccg ctggaaatgg ggtcggcgcc gctgatggcg cgtacgagtt
    13441 cggtccggcc ggctcccatg aggcccgcaa tgccgaaaac ctcgcccctg cgaaccgaaa
    13501 agctgatgtc ccggaatgcg ttggacggcg acgagagatt tcgtacctcc agcgtcacct
    13561 ggtccgtcgg ggccggaagg gtcgggaaca tgcgctcgag tgagcgcccg accatggcct
    13621 cgacgatcgt gcgtatcggc acgtcgccac tctcgaactc ctgcaccttt gcgccgtcgc
    13681 gcatcacgac aatgcggtcg gcgatcttgc ggatctcctc caggcggtgc gaaatgtaga
    13741 tgatgccgac gccttccgac ttcagccgtt cgatctgccg gaagaggagc tgggtctcct
    13801 cggcgccgag cgcggccgtc ggttcgtcga gaatcaggag gcgcgcattg agcgtcaacg
    13861 ccttggcgat ctcgatgagc tgctgcttgc cggtcgaaag cccgtcgacg aggcgatccg
    13921 gcgagatgtc gagaccgagc cggtgcaggc cgctgcgtgc ccgatcttcc atagttttgc
    13981 gatcgatccg ccccgccttc atcgggtagc ggccgacgaa cacgttctcc gcgatggaga
    14041 gcttcgggag cagtttcagt tcctgatgga tcatgcctat cccctcctcc atcgcggcac
    14101 ggggatctgc gggggcgtag gccctgccca gccaggtcat ttcgcccgct gagggttgca
    14161 cggtgccgga aataatgttc gacagcgtcg attttccggc accgttttcg ccgagcagcg
    14221 ccaccacctc tcccggatgg atatcgaggt cgataccgtg gagaaccttg atcggaccgt
    14281 aggatttgcg gatgcgacgg agcgacagga tgggagagtg gggcgtcatg gcgctgctgc
    14341 ctttcggcta tcgggttacg gatggttctt tacgaattcc ggagcgttgt cgcaggtcgt
    14401 cagcacggca ttcggcgtct gacgctcttc gaccttctcg cccgccgcaa cggcaagtgc
    14461 ggattcgacg gcaagaacgc ccattttttg cgtgctctgc gttgcggtgg cgatgaacgg
    14521 gcccttgcac ctggcgaggt attcgagcgc cgagacgtcg ccgtcatagc cgccgatgat
    14581 caccttgtcg gagagattgg cgacgtcgac cgccttggcc gcccccatgg cgagaccgtc
    14641 ggcctggccg aaaatgatcg tgatgtccgg atttgcctgc agcatgttct gcgcgatcga
    14701 gaagccttca tcggccgacc acatgttgct ccactgctgg tcgataagct cgacgccctt
    14761 gttctcgtca atggcgcgct tgcagccggt gaagcggtcg acctccggcg ttgtgccctt
    14821 ctgcccgtgg atgattgcca tcttgcccga gccgccggcc ttctcgatga tgaacttgca
    14881 gacggcgtag gcggattcga cgctctctcc ggcgatgaag gtgtcgcccg gcgcaccctc
    14941 cgggacgcgg tcgacgttga tgaccggaat gccggcttcg cgggcaaggc gggtcgggac
    15001 cgcagccgcc gcggcaccgg ccgggatata gatgaaggcg tcgatgtcct ggatcatcag
    15061 gtcctgtacc tggctgacct gcgtgttggt gtcgttcttc gcgtcgacga ccaccacttc
    15121 gaggcccttt tccctggcgt gcttttcgac accgagcttg atctggttga agaagtcggc
    15181 ctgaagattc ggaacagcaa ggccgatctt cttgatctcg gctgcggatg cgggaagcgc
    15241 aaggaccgaa gcggtggttg cggccaccag cagtgtggac agtttcatag tttctcctcc
    15301 gatttgcccg gtggcgccct gccctcgcag gaagtcacct tctctttgcc ggccggcacc
    15361 attgctggcc gttttcagcg ccccaccgaa gttcggcaac ggggcgaatg tcgctatttc
    15421 cgcttgcggt acgtttccgc cgtgacggcg agtacgatga cggcaccgat gatcacctgc
    15481 tgcatgaagg gagacacgct gagcaggttc agaccgtttc gcaggacacc gatgatgagc
    15541 acgccgatga tggtgccgcc gatccccccc gttccgccgg aaagcgaagt accgccgatg
    15601 acgaccgccg cgatggcgtc gagctcatag gacacgcccg acgacggctg gaccgagtcc
    15661 agacgagccg caagcaccat gccggaaaga cccgcgagga agctgcagac gacatagacg
    15721 agcacggtcg cgcgctgaac gtcgataccg gcaaggcgcg ccacttcggc attgccaccg
    15781 acggcgtaaa gcacgcgccc gccatgccgg tagcgctggt agagaagtcc gacgatgaag
    15841 accacgatca tcacggcaac ggtcagcgtc aggaagccac cgaagcgaac gatggccatc
    15901 atgttgaacc aggccggaaa gcctatgatc tgctggccgt cggtgaccat gttcgcaagg
    15961 ccgcgcgtga tcgacatcat ggcgagcgtg gcgatgaagg ccggtacgtt gaagcgggtt
    16021 atgaggaggc ccgcgatgag gccgtttagc gcggcggcgg cgagcgccag gggaatggcg
    16081 agccacatcg gcacgccggc cacgacgtgc aggtagccga gtaccatcat cgccagcgcc
    16141 atgaccgacc cgaccgcaag gtcgatacct ccgatcagga tgacgaaagt catgccgaca
    16201 gccatgacgc ccagcaccgt gatctggtcg agcacattga ggaaattccg caccgacagg
    16261 aacttgtccg tcgcgaaggt caggaaaagg cacagcacga tcagcccgat cagcggaccg
    16321 gtcgcgccct tcagtgacgg aagcagcctt acggcagccc cttgcttgtc ttgcaccgca
    16381 gcccgcatgc gccgtcctcc cgcatagccg cttcccgttg ccggtaagca taattattca
    16441 ttagtgtgtg taaattcata cacgaccaat cctgaggctg tcaatacgag ggaggctgca
    16501 atctcgcggt tgctattgcg gaattccgct tgacttgcga gagggacgtg caaatatatg
    16561 atcaatagca tatttattca caatgaggat ttcatgcagc cgaacgatct cgaccgcatc
    16621 gctcaacaga tccgacttcg cgatctgcaa gcggttttcg aagccggcgc cggccacatc
    16681 ggcggagaga tgtccgccat cgacattctg acggcgctct attttcgcgt gctgcgcatc
    16741 tggcccgaac agccgaagca cccggaccgc gaccgtttcg tgctgtcgaa aggccatgtg
    16801 gcgctggcgc tctatgtgac gctggccaag cgaggcttca ttccagagga agaaatcggc
    16861 acattcctga agccgcattc gcgcctcaac gggcatccga actgcaccaa ggtgccgggc
    16921 atcgagacga ataccggccc gctcggccac gggctgccgg tggcggtggg catggcgaag
    16981 gcggcaaagc tgacccgcgc gaaatatcac acctatgctt tgaccggtga cggcgaaatg
    17041 caggaaggat ccaactggga ggccatctca tcggccgcgc aattcggtct cgacaacctg
    17101 accctgatca tcgaccacaa ccgcttccag cagggcgccg ctctgaagga taccaacaat
    17161 ctcgctccat tccccgccaa actcgaagcc ttcggctggg atgtgaccga gatcaacggc
    17221 aatgccatgg atgaagtcgt tccggcgctg gaaaagcgcg gcagtcgccc gcactgtatc
    17281 gtcgcccata cgaacaaggg ccacggcata tccttcatgc aggacaaggt cgactggcac
    17341 cacaaggtgc cgaacgacga acaatacaag attgccgtgg ctgagctttc ggaggccctg
    17401 tgatgaacgc cgtgacatcg tctgccaagt tgcacgattg ccgtgacgcc ttcgttacgg
    17461 tgctggagcg cctcagtgcg gataacccca ggatcgtggc cgtctgcaac gactccgtcg
    17521 gctcctccaa gctcggcggc ttcagagcca ggtggccgga ccgactggtc aatgtcggca
    17581 tcgccgaaca gaacatggtc ggtgtcggcg ctggccttgc caatggcgga ctgctgccct
    17641 tcgtctgcgg cgccgcctgt ttcctcacgg gccggtcgct ggagcagatc aaggccgaca
    17701 tcgcttattc caacgcaaac gtgaagctca tcggcatttc ctccgggatg gcctatggcg
    17761 agctcgggcc gacgcaccac tccatcgagg atttcgcctg gacccgcgtg ttgccgaacc
    17821 ttccggtcat cgcaccctgc gactcggtcg aaaccgccgc ggccgtcgaa tgggccgccc
    17881 attatgatgg cccggttttt ctgcgcctgt cgcgcgtcgg cgttccggac ctgctgccgt
    17941 ccggccacac attcgaactg ggcaaggcca acctgttgcg ggacggcgac gcgatcaccc
    18001 tcgtcgccaa cggcacggtg acccaccgca tcctgaaggc tgccgatctg ctggcggcag
    18061 agggcataga ggcacgcgtg ctgaatatgg cgacagtccg gccgctcgat ctcgatgccg
    18121 tcgtggccgc cgcgcgcgag accggagcca tcctgacggc ggaagagcat tccaccttcg
    18181 gcgggctcgg ttcggccgtg gccgaacttg tcgtggccga agcgcccgtg ccgatgaaga
    18241 tcctcggcgt tccgggaatt ttcgccccga ccgggtcggc cgaattcctg ctcgacgaat
    18301 tcggcatgtc ccctgccgcc atcgccgaag cggccgtcgc actgatcgca cgaaagccct
    18361 cccgcgcatg atcatgcgca ggtagatttc gtgccgggcg cggcaatcct cctgccgcgc
    18421 cccattcctg tctgccggag ccgccatgac gactgccatt ctcgccatcg accagggcac
    18481 cacgaattca aaagccgttc tcgtttcgac gaccggtgag atcctctcgc gtggcgcatc
    18541 gccggtcggc atcgaacatc cgcagcccgg ctgggtggag cagaacccgc ttcgcatctg
    18601 ggaatcggtt caggaggcga ttgccgcctg cctgcagaag ggaccccgat ccgacatcct
    18661 cgggatcgcg atctccaacc agcgcgagtc ggtcaccgcc tgggacgccg caacgggcaa
    18721 gccgctcggc ccggtggtca gctggcaatg ccgccgcagc gcgccggcct gcgccgaact
    18781 cagcgccgca ggccatgccg agcgcgtccg ggcgctcacg ggtctcccca tagaccctat
    18841 gttccccggt cccaaaatga ggtggctgct cgatcgcatt cccccgggac atgaggtccg
    18901 gctgggcacg atcgacgcgt ggctgatcca ttgcttcacg gctggcgcga tccatgcctg
    18961 cgatgccggc aatgccgccc gcagccagct ttacgacctc aaccgccggg cctggagcga
    19021 cgagctttgc gacctgttcg gcgtacccaa atccgccctg ccggaggtgt gcgacagcgc
    19081 cgcccgcttc ggcgtcacga agaatgtgcc ggggctgaag gacggaatcc cgatcgcctc
    19141 ggcgatcggc gacagccacg ccgcgctttt cggccacggg gccttcaatc ccggcgacgg
    19201 caaagtgacc ttcggcaccg gctcttctat catgacgacc ctaccccgct tcatcgctcc
    19261 cgagcagggc attacgacga cgatcgcctg gtcgatcgcc ggccggccga cctatgcctt
    19321 cgagggcaac attctcgttt cggccgcggc ccttccatgg atggccgaaa tgctcggcct
    19381 ttcccatgtg gaggacctga tcgatctcgc cgccaccgcc gagccccgcg gcccgggttt
    19441 cgtgccggcc ttcgtgggtc tcggcgcccc ttactggcac gccgatgcac gagcgctgtt
    19501 ttccggcata accttcaaca cgacgcgcgc ccagatggcg cgtgcggtca cggactcaat
    19561 ggccttccag gtccatgacg tcttcaaggc gatgtcggca caatcgccga caccgctcgg
    19621 ccgactctat gcggatggcg ggccgagcaa gaacactttc ctgatgcaat gcgtggccga
    19681 taccctgaac catgtcatca ctcagtgcga cgcgccagag gcctcggcgc tcggcgcagc
    19741 ctatctggcg ggtctctcgc tcggcgtttg gcccgatctc gccgctgtcg cttcactgcc
    19801 gcgcgccggc aaacccgtgc tgccgcgccc ttgcgacgcc gcagatcgcc tcatggtttg
    19861 gcaggacgca atctaccgct cgaccgttcc aggtccttca attatgagtg aataaaaatt
    19921 caccactgga ggatcccgat gggacggctc aacgagcttc gactgatcgc ccgcgtagcc
    19981 cagatgtacc atatcgaaag caagaggcag gccgagatcg ccgaaatcat gcacatgtcg
    20041 caggcaaccg tttcccgcat gctgaagcgc gccgagcagg aagacatcgt gcgcaccacg
    20101 gtcattcccc ccgccggtac ctttgcggat ctcgaaactg cattgcgcga gcgctatggc
    20161 ctgaccgaag cgatcgtcat cgactgttcg gaagatcgcg atggagcgat catggcgcgc
    20221 atcggcgagg cggctgccca tttcctcgaa gtcacgctgc agcaggacga gatcgtcggg
    20281 gtatcgagct ggagtcagac cattctgcgc atggtggaca acatccaccc gctgaagaac
    20341 gccaaggcga agtacatcgt gcagatcctc ggcggcatgg gcgacgcctc ggtgcagacc
    20401 catgccacgc agctgaccgc gcgccttgca agactcaccg gcggcgagcc gcgattgctt
    20461 ctcgttcagg ggatcacctc ctcacgcgag gcgaaactcg tcatgctcgc cgacccggtg
    20521 gtgcgcgaga cgatggacct cttcggccgc ctcagccttg cgatcatcgg cattggcgcg
    20581 gtggaaccat cggaactgct cgcccgctcc ggcaacacct tctcccgcca ggaaatggcg
    20641 atgttgcacg aggccggggc ggtcggcgag atttcctacc gattctacga caagggcgga
    20701 aagccggtcg aaaccccgct taacgaccgc gtaatcggca tctcgctgga agacctgcgc
    20761 aagaccggcc gcgtcatggc gctcgcgggc ggcgaatcca aaacccaagc cattgccggc
    20821 gcccttagac ttggcgttat cgatgtgctc gtcaccgaca agttcacagc agctcggctc
    20881 acggcctgat ctgaagatcg gtcctggccc gttgc
//
