LOCUS       NZ_CP084582            25068 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Micromonospora aurantiaca strain G9 chromosome, complete genome.
ACCESSION   NZ_CP084582
VERSION     NZ_CP084582.1
KEYWORDS    RefSeq.
SOURCE      Micromonospora aurantiaca
  ORGANISM  Micromonospora aurantiaca
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Micromonospora.
REFERENCE   1  (bases 1 to 7149079)
  AUTHORS   Schneider,B., Pfeiffer,F., Dyall-Smith,M. and Kunte,H.J.
  TITLE     Genome Sequence of Micromonospora aurantiaca Strain G9, a Member of
            a Bacterial Consortium Capable of Polyethylene Degradation
  JOURNAL   Microbiol Resour Announc 11 (5), e0114821 (2022)
   PUBMED   35389268
REFERENCE   2  (bases 1 to 7149079)
  AUTHORS   Schneider,B., Dyall-Smith,M., Pfeiffer,F. and Kunte,H.-J.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-OCT-2021) 4.1, BAM Bundesanstalt fuer
            Materialforschung und -pruefung, 12205 Berlin, Unter den Eichen 87,
            Berlin, Berlin 12205, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. SEPT-2021
            Assembly Name                     :: BAM_Maura_1.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 427.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 09:59:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,512
            CDSs (total)                      :: 6,447
            Genes (coding)                    :: 6,372
            CDSs (with protein)               :: 6,372
            Genes (RNA)                       :: 65
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 75
            CDSs (without protein)            :: 75
            Pseudo Genes (ambiguous residues) :: 0 of 75
            Pseudo Genes (frameshifted)       :: 25 of 75
            Pseudo Genes (incomplete)         :: 59 of 75
            Pseudo Genes (internal stop)      :: 6 of 75
            Pseudo Genes (multiple problems)  :: 15 of 75
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:21:19
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4871125
            Orig. end                         :: 4896193
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP084582.1.
            Bacteria and source DNA available from BAM, FB 4.1, Hans Joerg
            Kunte, Unter den Eichen 87, 12205 Berlin, Germany.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25068
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="17"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25068
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25068
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15068](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15068
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(9..22)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.83"
                     /tool="antismash"
     gene            748..2181
                     /locus_tag="LF814_RS21925"
                     /old_locus_tag="LF814_21945"
     CDS             748..2181
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018791140.1"
                     /locus_tag="LF814_RS21925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_21945"
                     /product="APC family permease"
                     /protein_id="WP_091331270.1"
                     /transl_table=11
                     /translation="MHTRQTAPPPEIGLAQASPDSSRFGYRPELRRSLGFADLLFYGLV
                     FMVPIAPMGIFGSVYSGAGGMVALAYVIGMAALVFTAASYAQMVKAFPLAGSVYNYAGR
                     GIGAPVGFLAGWAILLDYVLVPSLLYLIAAVAMHSTVPAVPVWVWLVGFVLVNTLVNYR
                     GIRMTALITRVMLVGEIIVLVIFLAAAGRALTQGKGQGFSWAPIYNPDTFTWALVFGAV
                     SIAVLSFLGFDGISMLAEENKGGAGQIGRAMAAALGVAGLLFIAQTWMAALLLPNPDGL
                     LVNGDPEGTAFYDAARLAGGPWLATLCAVATAVAWGVANSLVAQVATSRLLYAMARDRQ
                     LPKFLAKVSVRHSVPTHAITLTALVSLTIGLYMNWRDDGIALLSSLINFGAMTAFLVLH
                     LAVVWHYLVRRRSRNLIAHLILPGIGFAILAYVVVNANVAAQRLGFVWLTLGLLALANL
                     YAAGRRPELSGLASGREAA"
     gene            2178..3203
                     /locus_tag="LF814_RS21930"
                     /old_locus_tag="LF814_21950"
     CDS             2178..3203
                     /GO_function="GO:0016811 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds, in linear amides
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020217616.1"
                     /locus_tag="LF814_RS21930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_21950"
                     /product="acetamidase/formamidase family protein"
                     /protein_id="WP_091331269.1"
                     /transl_table=11
                     /translation="MTSTVTYQPTEDELHYTFGAHPAVAEIKPGSLLVTSAEDCFGGAV
                     RTVDDLPSKVCQAFNPVTGPFHVLGAEPGDTLALHFAAITPARDWGMSATFPHFGALTA
                     THTTPMLHPPLEERVWRYTIDTAAGTVTFHARRSGHAIVMPLEPMLGTVGLAPAGGEAR
                     STVVPDAHGGNLDTPEIRPGTTVYLGVNAPGALFAIGDGHARQGQGEVCGVAVETAMNV
                     TVAVDLIKGVATPWPRIETDHRIISIGAARPLEDAYRISQHDLVTWTAQLTGLELLDAY
                     QVVSQAGRAAPGNVCDPLYTMHAAVNKAILAGMSPYEGVHQRLRHIAKAPSEQPGKDHG
                     N"
     gene            3193..4062
                     /locus_tag="LF814_RS21935"
                     /old_locus_tag="LF814_21955"
     CDS             3193..4062
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018726147.1"
                     /locus_tag="LF814_RS21935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_21955"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_230650685.1"
                     /transl_table=11
                     /translation="MGTEAMSWAPAEVDLTRPNAARMYDYFLGGSHNFAADRHAADAIL
                     AVAPHVADAARANRAFLRRAIRYALQQGIHQFLDLGSGIPTVGNVHDIAHHIDIDARVL
                     YVDVEPVAVAHARALLDNDPRVDVIQADICFPDFILQNPTTQRLIDLTRPVAVLFVSVL
                     HFIPGDVNAIVEPLRAAMPPGSALVISHATSGTATSQTDEVQRLYQRTPTPLQLRAPAE
                     VEALFGDFAMVPADAPAAKSASNAALVPVARWRPDPEDQIERGHASASPFLTGFLAGVG
                     MKGAAARE"
     gene            4228..4902
                     /locus_tag="LF814_RS21940"
                     /old_locus_tag="LF814_21960"
     CDS             4228..4902
                     /GO_function="GO:0070273 - phosphatidylinositol-4-phosphate
                     binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018792215.1"
                     /locus_tag="LF814_RS21940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_21960"
                     /product="GPP34 family phosphoprotein"
                     /protein_id="WP_091331267.1"
                     /transl_table=11
                     /translation="MSFARLPLRDELFLLGHDDDAGHPHIHRQALALGLAGAVLIDLFL
                     AGRIVLDPNNDRLSGDRWLRLHTDQPLGDLIGDSAIGFIRYGRTAPPVKAFLRGFADDL
                     YERTRAGLVAAGILRQVTRRRLGGLARTDTYLATDTKWAVVARARLRYVAQGREQPDNH
                     TAALAGLVATLGLTGHLYLNDDSTTVTAHLKAIAGQHHRSVRDIIAALDAAVGDLATAT
                     YR"
     gene            4930..5583
                     /locus_tag="LF814_RS21945"
                     /old_locus_tag="LF814_21965"
     CDS             4930..5583
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013285713.1"
                     /locus_tag="LF814_RS21945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_21965"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_091331266.1"
                     /transl_table=11
                     /translation="MESLVHIRAARWADKDLVALLIADALHPTPLAAWLVPDPGQRCQV
                     LADVFAIWVEHAMFFGDIHLTDDLTAATVGFHRYRPIPPPANYRTRLTDAAGPNADRFD
                     LLDTLLAEKQPTEPHYHLAFLAVRTDAQRGGCGVALLAHHRSRLDRIDLPSWTAVPSGK
                     EPLLARYGYTPRPAITLPDGPTLQPMRRNARHGSSVMPINPARPVDNRWQGFHV"
     gene            6002..6781
                     /locus_tag="LF814_RS21950"
                     /old_locus_tag="LF814_21970"
     CDS             6002..6781
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LF814_RS21950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LF814_21970"
                     /product="hypothetical protein"
                     /protein_id="WP_141722614.1"
                     /transl_table=11
                     /translation="MAVADTVGRAILARAARIIPSTSTPIPPHLAAVHAHRVLARVTVG
                     ATPSDVTLTWRATPVPEPGRFEAERAQRVATARTLVLSDPLRARQLLHASLTGVDPATA
                     PAHPLHAEAAILLAELQLRLGHPADAMDWATYARASTVHLHGPTHRRALHALHVLAAAH
                     SRGGHHQRAYHLYRELTGHLTKTDGPHAQQTLAVQAATALILHALGHCQAARTLLADTI
                     TTHRREHPGHPATAHMTRHLSRIWRECATNGHQHQDA"
     misc_feature    complement(6833..6847)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.92"
                     /tool="antismash"
     misc_feature    complement(6907..6917)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 19.65"
                     /tool="antismash"
     gene            6992..8263
                     /gene="fxlM"
                     /locus_tag="LF814_RS21955"
                     /old_locus_tag="LF814_21975"
     CDS             6992..8263
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018802441.1"
                     /locus_tag="LF814_RS21955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_21975"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_230650688.1"
                     /sec_met_domain="PCMT (E-value: 9.1e-38, bitscore: 128.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVRPDEKEVRVTQMAEPRTSADRAAQLRAALVDTLRDEGMVTRA
                     LVEAAVRVVPRERFMPAGTPLEVAYAYDNSVVTKRDQHGMAISSVSAAYIQARMLELAE
                     LRPGMTVLEVGSGGLNAAYIAEIVGPEGRVVSIDIDPEVIDRAATALDATGYSSRVRVL
                     VADAEHGVPDEGPFDAIIVTVGAWDIAPAWLGQLAPDGVLVLPLIMNGVTRTIGFRRDG
                     DQLVSTSAEVAGFVPMQGAGSHANQVLELADTTGGKVKLSFDSGAPPDLIQLDGVLNAG
                     AAEWWSGVTVSHGISFADLHLWLAWYLDGFCRLAADEGSALAARKRWLPFAVVRGAGLA
                     CLVLRDAMQGAGAEFGARAYGRDGQVAAAALIEQIQAWDRAGRHTPPTFAYWPAGGDRS
                     QIRADATVMNKTHGVVTISWPTSS"
     misc_feature    complement(8377..8387)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     gene            8377..9585
                     /gene="fxlM"
                     /locus_tag="LF814_RS21960"
                     /old_locus_tag="LF814_21980"
     CDS             8377..9585
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04364.1"
                     /locus_tag="LF814_RS21960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_21980"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_091331263.1"
                     /sec_met_domain="PCMT (E-value: 3.8e-44, bitscore: 149.5,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLQVDDATTLRQAMVGTLRDEGLITTDSVAAAMNAVPRHEFAPG
                     EPLEKVYQTNSTLVPKIDAQGRQTSVVSASHIQAIQLELAEVRPGMNVLEIGSGGYNAA
                     LIAEVVGRTGSVTTVDIDADVVDRARAGLRRAGYEQVNVVLADAEHGVAQHAPYDRIIV
                     TVGAWDIPPAWLDQLTPDGRIVVPLRFAGITRMVAFDRTPGMSVLTASSYRLGSFVPMQ
                     GDGAASEQLIPVTPDVGLRLDQNSALTFDVPALRKALNTKPVESWSDTPFDMPDELELY
                     LLTSGPELPMLHAAQAAVDQGVVNRTVRNGTPTLVRGGSFAYRIKRENPQTVSGYETGV
                     IAHGPEAEQVGGELLAMIRTWADCYYRRGAAHITYHPNTADTSDLTGWHSTKRHGVLAI
                     AWS"
     misc_feature    8425..8438
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.19"
                     /tool="antismash"
     gene            9665..9829
                     /locus_tag="LF814_RS21965"
                     /old_locus_tag="LF814_21985"
     CDS             9665..9829
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018724312.1"
                     /locus_tag="LF814_RS21965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_21985"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_082171406.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 7.8e-16, bitscore:
                     56.3, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLATVQPDVEGGTLDDFDLDIEFIEAGGTVEHIIKMTEDNCGS
                     TCASACTSC"
     CDS_motif       9665..9769
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MAQLATVQPDVEGGTLDDFDLDIEFIEAGGTVEHI"
                     /locus_tag="LF814_RS21965_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9770..9829
                     /prepeptide="core"
                     /locus_tag="LF814_RS21965_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-10.50"
                     /molecular_weight="1817.0"
                     /monoisotopic_mass="1815.7"
                     /core_sequence="IKMTEDNCGSTCASACTSC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAQLATVQPDVEGGTLDDFDLDIEFIEAGGTVEHI"
                     /leader_location="[9664:9769](+)"
                     /alternative_weights="1835.1"
                     /alternative_weights="1853.1"
     gene            10001..13015
                     /locus_tag="LF814_RS21970"
                     /old_locus_tag="LF814_21990"
     CDS             10001..13015
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="LF814_RS21970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_21990"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_091331262.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 3.1e-173,
                     bitscore: 575.9, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 5.5e-13,
                     bitscore: 48.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 6.9e-20, bitscore:
                     70.4, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYRSVNDALMLRAAVLRPGQLGAWPDLTGSDTAARWRSWLAETLT
                     IPGFAAALAHASPDLAERVTAAISGGLSQADARRVVLAVMRYLLRTTTRATPYGLFAGV
                     APATASRTGRMRWGTAHRPFARLQASWLAAVLDGLESDVRLRPHVMVRANNLLVERSEK
                     LVLEYRAATTDPAGAPTHLRIKATDMIRTALALAADPIRWADLTGKLTAECGAPQEGAQ
                     RLIEQMVTQRLLLTSLRPPSTETDPLAHLVDQLETAAAEGGEVGELLDPLRRVRDLKAR
                     HDRAPDGATAAARRRDLGRAAAVIQPGQAVGVDLRLDCDLVVPTTVTAEACRAAAALTR
                     LARPTSLRWRDWHTRFLNRYGLHALVPVLDAIDVQVGFGYPDGFTGEPANDSAALTDRD
                     RRLLALAQRAALRREHEVDLDDVLLDRLAGPAPTEIPPTAELTVRVHADSLQAIAGGNF
                     LLSVVRVSAQAFSTAGRFLDMFGETDWHRMASCAVDSPPASAGALLAQLSAVTRYTISL
                     DVNRAPQVLPHLIPVGEYHAPSQAAISLDDIAVTADPHRLYLVSISRRRALQPVAVNAV
                     EPVRHAHPLARFLAEAPVALATPCSPVEWGPAANGLPFLPALRYGRTLLSPARWHLSAA
                     ELPDRHAGWQHWTRALTAWLEATGCPTAVSLGIGDQTLGLDLDKPAHRALLRDHLTRNP
                     TALLRLIPEGDAWIGGRPHEIVIPLTATTPRPPAPRLTSPLVDVRTHGSLPGRDHHYLK
                     IYARPEEQTTILTAHLPRLVGQLPPAGGWWFLRHADPEPHLRLRISGLPIDAITGWTQE
                     LTDADLTRRVQWDTDFGEPGRFGSLAAYHATTALFAADSAAALAQLAVTTRRPTLGWQA
                     LTAASMVDLVTAVIGDPHDALRWLIARTRPHRPAPPRAVYDQAIRLANPYDPTAVASLP
                     GCENLTDRWAERRRTVAAWRDRLPAVSTIPPAELLPDLLHLHHVRVAGADLDSERACLH
                     LARAAALSWTTRSTS"
     aSDomain        10451..10723
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_LF814_RS21970_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.40E-15"
                     /identifier="RREFam001.1"
                     /label="LF814_RS21970"
                     /locus_tag="LF814_RS21970"
                     /protein_end="241"
                     /protein_start="150"
                     /score="48.0"
                     /tool="antismash"
                     /translation="VRANNLLVERSEKLVLEYRAATTDPAGAPTHLRIKATDMIRTALA
                     LAADPIRWADLTGKLTAECGAPQEGAQRLIEQMVTQRLLLTSLRPP"
     gene            13012..14235
                     /locus_tag="LF814_RS21975"
                     /old_locus_tag="LF814_21995"
     CDS             13012..14235
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="LF814_RS21975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_21995"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_222433956.1"
                     /sec_met_domain="LANC_like (E-value: 1.9e-36, bitscore:
                     124.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPTTTANRSDVLAAVCVRLASPSIVGSSPDGRTRPQSLAGGAV
                     GIALLHIERAVSGHGDEATAHLWIRAAGSEPVSIGRNSDPFHGAPALAFMLHTARPLGG
                     YRRAFASLNDATITLTRQRLAAAHARIDRRDPLTMYEFDLVHGLTGLGLYHLHAHPEHP
                     ISRDVMTYLARITEPLDNGSTQPPWWLPSGLGGTPHPDFPHGHGNIGVAHGISAVIALL
                     AHAILHGHDTPAARNALAALCDWTDHHRQDDPAGTWWPGYVTPDTTPRRHRPSWCYGTP
                     GIARAQQLAGLALRDTARQQRAEDALLAVLRDAAQRARLPEIGLCHGKAGLLQTASRLA
                     AASTDPHRAGQLTAELPGLAAELANQLASQAQGDPELLNGTAGAVLALQTAVTGSPATS
                     WDTFLALA"
     gene            14253..15068
                     /locus_tag="LF814_RS21980"
                     /old_locus_tag="LF814_22000"
     CDS             14253..15068
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03891.1"
                     /locus_tag="LF814_RS21980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_22000"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_145824144.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1e-21, bitscore:
                     76.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPPKWRQTTIAFPDPHAADQVATAQLAPILVDAETRQLITTWFY
                     VRKDTWRLRYLPASTTADHYLTSQLTRLRHNRHISAAVPGIYEPEAHAFGGTRAMDTTH
                     QLWHHDSRQLLTPDTNHLATRQPELSIMLTAAMMRAAGLDWYEQGDVWARVANHRDPPQ
                     PTLVNNLLHAVKRLLTADPASLTHQGAPLAATRSWFEAYIAAGDTLNRLNQTGQLQRGL
                     RATLAHHVIFAWNRRSIPGLHQAAIATAAKTIIFGPKPTSPALTPDGDS"
     misc_feature    14976..14978
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            15188..16213
                     /locus_tag="LF814_RS21985"
                     /old_locus_tag="LF814_22005"
     CDS             15188..16213
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LF814_RS21985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LF814_22005"
                     /product="hypothetical protein"
                     /protein_id="WP_145824143.1"
                     /transl_table=11
                     /translation="MAAATAVFNLAALLASDCDMPDLAHTWCHRLATAALDHGSDPQHA
                     LEPIVNLARLHIRAGDGPTAWTLLETLFQAIDTRTDTLIDGLTIPAARLTEAPGAHTKT
                     RTWLWTVLLGTGAHALATAGRWDDASHRLTQYNGVGARMLDGRQISVIAHATAGRYRQA
                     RAMLDATQPGEPWEDAVTACLLLLMPDSDPTDDQANKALTAYHALGPAKPGLTVFHTRL
                     GLTLLDALDKDHPAAEQLAVELIQHAAGDGYAARDLLTHPTCLAAAHHQRVNQLKTLVS
                     TCGLDAGTLSAAQLRALLRALDIAESVIRAPASGLPAEGLPDPPSEPDNSLQRGSSDTP
                     R"
     gene            16362..16817
                     /locus_tag="LF814_RS21990"
                     /old_locus_tag="LF814_22010"
     CDS             16362..16817
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LF814_RS21990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LF814_22010"
                     /product="hypothetical protein"
                     /protein_id="WP_230650690.1"
                     /transl_table=11
                     /translation="MLRTAHDVYAYMFREEHLQDPGLDLVPDGTLLMLRECGTLMALNR
                     VELDGHISNVSPAWMLCAVRVVYDLDKATAEVLDELYHGTWFNESRRRESILAHAALGG
                     RLVHACQGAPNMSGSCVVPFGTDVETMRRELAGMRVPWIERTLAPLT"
     gene            16946..17314
                     /locus_tag="LF814_RS21995"
                     /old_locus_tag="LF814_22015"
     CDS             16946..17314
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LF814_RS21995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LF814_22015"
                     /product="hypothetical protein"
                     /protein_id="WP_145824142.1"
                     /transl_table=11
                     /translation="MAIARDTSGRVVTVRDMLDGISTSLKYTNYQLDTAGVGHEPHPWN
                     WTESAGHFRSVVTKEAELAEHIARTIDRWVKANQDADAANLAAMRTASKDLKAAARSLV
                     NLGKKMRNVQACLDVTQS"
     misc_feature    complement(17377..17391)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.9"
                     /tool="antismash"
     misc_feature    complement(17402..17415)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.83"
                     /tool="antismash"
     misc_feature    complement(17931..17951)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.48"
                     /tool="antismash"
     misc_feature    18388..18404
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.07"
                     /tool="antismash"
     misc_feature    complement(18388..18404)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.65"
                     /tool="antismash"
     gene            18779..19942
                     /locus_tag="LF814_RS22000"
                     /old_locus_tag="LF814_22025"
     CDS             18779..19942
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1237: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014691928.1"
                     /locus_tag="LF814_RS22000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_22025"
                     /product="IS110 family transposase"
                     /protein_id="WP_145824140.1"
                     /transl_table=11
                     /translation="MAQVIIGVDPHKRSATIEIINAREKALGQGRFGTDRDGYQAMLAA
                     GRKHKDRLWAVEGCNGIGRHVAQRLVADGETVVDVPAKLSARARVFATGQGRKTDPVDA
                     HSVAVVALRTEGLRQVVTDDTTVALRLLVDRRDQLGRARTEVVSRLHHLLLELVPGGAK
                     KDLSAQQARALLGSVRPRDVVGKTRRRLASELIGELVVIDKKIKTAKQELTDLVNSTGS
                     RLMNLTGIGPSGAARLLGDIADIARFTSRAHFASWNGTAPIDASSGDQNRHRLSRAGNR
                     RINRALHIMAIVQLRRDTEGRRYYRRRLAAGKTPMEALRALKRRLSDIVYRQMVADAKL
                     VRTGPGGHAGATLQSSAADLNPEIDTSEKSLPGPATPQPRTPLLIIT"
     misc_feature    18807..18820
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.97"
                     /tool="antismash"
     misc_feature    19163..19165
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            20008..20745
                     /locus_tag="LF814_RS22005"
                     /old_locus_tag="LF814_22030"
     CDS             20008..20745
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LF814_RS22005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LF814_22030"
                     /product="hypothetical protein"
                     /protein_id="WP_145824139.1"
                     /transl_table=11
                     /translation="MDTLTAMVEAGSGTALGRLLAHRWPEVAATAGALRPELDAVLTGG
                     AAAPSLVRRLAPMLGLDTADLFVIAGLDLPQDLVPASGTGPWHVGTVLEIAAKLAPQSL
                     RRLHEFVRSLPEHPPAWPPVRPRYRYALGPGEVMLRLLRNRNIGPYSPKLLYLIGGGPM
                     VSHSTVAMLGPGRTRLTPQYVTSFATVLGIPDDNLAAVAGVAAATDPRLHRNRVELARL
                     AWDARRLTGEQLSEVLDLAGRLR"
     misc_feature    20326..20328
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    21075..21088
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.57"
                     /tool="antismash"
     misc_feature    complement(21154..21163)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.29"
                     /tool="antismash"
     misc_feature    21160..21174
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.12"
                     /tool="antismash"
     gene            21397..21921
                     /locus_tag="LF814_RS22010"
                     /old_locus_tag="LF814_22035"
     CDS             21397..21921
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287267.1"
                     /locus_tag="LF814_RS22010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_22035"
                     /product="hypothetical protein"
                     /protein_id="WP_145824137.1"
                     /transl_table=11
                     /translation="MEIRNIGGRPHTDIAGAAELTGRSEQTVRLKTSPKQRAQGSGWPA
                     SVKQDKKAWLPIDELEHVRDVLLPQIVESSRARVHHVDLNGDPEELISATGFREILTIT
                     QGGWDKYVGMSKAAWDRGEDGYLPMPDCEEPAPVQGSTRYWKRRRVQEWINTRSGKVLS
                     ATPPDLPTSDS"
     misc_feature    complement(22240..22249)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.45"
                     /tool="antismash"
     misc_feature    complement(22267..22282)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.93"
                     /tool="antismash"
     misc_feature    22321..22334
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.62"
                     /tool="antismash"
     gene            22506..23645
                     /locus_tag="LF814_RS22015"
                     /old_locus_tag="LF814_22040"
     CDS             22506..23645
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287268.1"
                     /locus_tag="LF814_RS22015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_22040"
                     /product="DUF932 domain-containing protein"
                     /protein_id="WP_186461708.1"
                     /transl_table=11
                     /translation="MSNALDTIPLATRHATLPDLHRILDLQQAHKLDIVAGTAMLRAEA
                     GHLRITGAEPILSESGVTPSDGLYRPTELGDAGLGEKLGIPTSYLRKTRAQALHLYDAN
                     INGWLDLSQGKRYLARCLSDGNGGGILRAFLSDGYKIIDNLDVLMAVLSGIRESGMSVK
                     LDCDLSERRMVVRVHSEAIKSLARNLLRNYRSPFTGATGADNPTVFAGLVFTNSETGSG
                     AFTVTPRIVVQVCDNGLTITKDALRAVHLGAKMDEGTIRWSNDTHQANLNLIGKQTRDA
                     VRRFLDVRYVQRKIEEIEEKAGRRVPDPDHTIRVVAQRLRFTEDEQRLILNHFIDGGDR
                     TAGGIMHAVTSAAKTLTDPDAAYEMEGVGIRAMEIAATL"
     gene            23845..24381
                     /locus_tag="LF814_RS22020"
                     /old_locus_tag="LF814_22045"
     CDS             23845..24381
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287269.1"
                     /locus_tag="LF814_RS22020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_22045"
                     /product="hypothetical protein"
                     /protein_id="WP_145824136.1"
                     /transl_table=11
                     /translation="MPLFIGLPHGVSLPRNLAEPDARHLVSVLARTYQWTGPLFGRAEV
                     EAYLRAQADDPGSLHDPALNTEDWRRVQNTAAWKNLAATARRAVTTADVIGQALRQAGL
                     YCAQCDSPIAGPSTANWGLCPTCLNAADIRDLQTRPCPAGDGVSPHRWNSTTCTECTMP
                     APAARPRLTAVATAA"
ORIGIN
        1 caggctatgc actcagcgtc attgtcgcag tcggcagcgt agtagacgac ggcgggcgca
       61 gacgagctga aactaggaca acactagaac gtccacgcat cgtcatggga caggccgaac
      121 ccgcaggctg gtcgcacaga cgaccacggc gatggatggg cgctgcggct tcgcgctacc
      181 tccactgctg tggcagccct cgcgtttgcg agcagcggtg atggtggagg tgtcctcgtg
      241 gtcgtcgacg tgcgaagcga cagcgtgcgt gaccgcgctc gctgtgccgc ttccggccgc
      301 ggtggtgagt ggctggcgca gcccggatca cctgtctcgg gggtcttcac cctcgagggt
      361 ctgccgcgct ggcgcggttg cggcacgcgc tgcagcccgt tcggagtgct cggtcagcgg
      421 gactacccgg gggccctgcg gttgccagct gaccggccgt ggatgccgag gacatcgaac
      481 agttcgttct ggagccggcg gcgccggcac cgggtttggt ggcggacgcc gcgtccgagg
      541 aacttggccc atcatccgcc gattgtcggt cgcccgtact tctcggcggc tgcgcccagg
      601 acttgtccat gatctggcgc ctctagcaac cgattcagca gctcccggcg atgcgtctgc
      661 cttcgaagcc gctgccgccg tttggccagc tctagcactg gcggaagtga gctggcgtcg
      721 ctgaccgaca ggaaggaatg aaacagcatg cacactaggc agacagcgcc tccgccggag
      781 atcggcttgg cgcaggcgtc gcccgactcc tcgcggttcg gataccgacc ggagctgcgc
      841 cgctcactcg gcttcgccga cctgctcttc tacgggctgg tgttcatggt gccgatcgcg
      901 cccatgggca tcttcggatc cgtctactcc ggcgccggcg ggatggtcgc gctggcgtac
      961 gtcatcggca tggcggcgct ggtgttcact gccgcctcat acgcccagat ggtcaaggcg
     1021 tttccccttg ccgggagtgt gtacaactac gccgggcgag ggatcggcgc accggtcggg
     1081 ttcctcgctg gctgggcgat cctgctggac tacgtgctgg tgccgagcct gctgtacttg
     1141 atcgcggcgg tggcgatgca ctccaccgtg cctgcggttc cagtgtgggt ctggctggtc
     1201 ggcttcgtgc tggtgaacac cctggtcaac taccggggaa tccggatgac cgccctgatc
     1261 acccgagtga tgctcgtcgg cgaaatcatc gtcctggtga tcttccttgc cgccgcgggc
     1321 cgcgccctca cgcaaggcaa gggacagggc ttctcctggg cgccgatcta caaccccgac
     1381 acgttcacct gggcgctggt gttcggcgcg gtgtcgatcg ccgtgctcag cttcctcggc
     1441 ttcgacggca tctcgatgct ggccgaggag aacaagggcg gcgcggggca gatcggccgg
     1501 gccatggccg cggcgttggg tgtggccgga ttgctgttca tcgcccagac ctggatggcc
     1561 gcgctgctgc tgcccaaccc ggatggcctc ctcgtcaatg gcgatccgga aggcaccgcg
     1621 ttctacgacg ccgcccggct cgccggtggt ccctggctgg ccaccctgtg cgcggtcgcc
     1681 acggccgtcg cctggggcgt ggcgaactcc ctcgtcgcgc aggtcgccac ctcgcggctg
     1741 ctgtacgcca tggcccgcga ccggcagctg ccgaagttcc tggccaaggt gtcggtgcgc
     1801 cacagcgtgc ccacccacgc catcaccctc actgcgctgg tgtcgctgac gatcggcctc
     1861 tacatgaact ggcgcgacga tggcatcgca ctgctgtcca gcctgatcaa cttcggcgcg
     1921 atgaccgcgt tcctcgtgct gcacctcgcc gtcgtctggc actacctggt ccgccgacgc
     1981 agccgcaacc tgatcgcaca cctgatcctt ccgggcatcg gattcgccat cctcgcctac
     2041 gtcgtggtca acgccaacgt ggccgcccaa cgcctcggct tcgtctggct caccctcggc
     2101 ctcctggccc tggcaaattt gtacgccgcc ggccgccgcc ccgagctgtc cggacttgcc
     2161 agcggacggg aggcggcatg accagcacgg tcacctacca gccaaccgaa gacgagctgc
     2221 attacacctt cggcgcccac ccggcggtcg ccgagatcaa gccgggcagc ctgcttgtca
     2281 ccagcgctga ggactgcttc ggcggggccg tgcgcaccgt ggacgacctg ccgtcgaagg
     2341 tgtgccaagc atttaatccc gtcaccggcc cattccacgt gctcggcgca gaacctggcg
     2401 acaccctcgc gctgcacttc gctgccatca ccccggcccg cgactggggc atgtcagcaa
     2461 ccttcccgca cttcggggca ctgaccgcga cccacaccac gccgatgctg cacccaccgc
     2521 tcgaggagcg ggtgtggcgc tacaccatcg acaccgcggc aggcaccgtg accttccacg
     2581 cccgccgctc cggtcatgcg atcgtcatgc ccctggagcc gatgctcggc accgtgggac
     2641 tggccccggc cggcggggaa gcccgctcca cggtcgtacc tgatgcgcac ggcgggaacc
     2701 tcgacacccc ggagatccgc cccggcacca ccgtgtacct cggcgtcaac gcccccgggg
     2761 cgctgttcgc catcggcgac ggccacgccc gccaaggcca gggcgaggtg tgcggcgtcg
     2821 cggtggagac agccatgaac gtcaccgtcg ctgtcgacct gatcaagggc gtggccacac
     2881 catggccgcg catcgagacc gaccaccgga tcatctcgat cggcgccgcc cgtccgcttg
     2941 aggacgccta ccgcatcagc cagcacgacc tggttacctg gaccgcacaa ctgaccggcc
     3001 tggagctact tgacgcttac caggtcgtct cgcaggccgg tcgagccgca cctggcaacg
     3061 tctgcgaccc gctttacacc atgcacgccg ccgtcaacaa ggcgatcttg gcaggcatga
     3121 gcccctacga gggagtgcac cagcggctgc gccacatcgc caaggccccg agcgagcaac
     3181 cggggaaaga ccatgggaac tgaggcgatg agctgggcac ccgccgaggt cgacctgact
     3241 cgtccgaatg ccgcacggat gtatgactac ttcctcggtg gcagccacaa cttcgccgcg
     3301 gaccgtcacg ccgccgatgc catactcgcc gtcgcacccc atgtcgccga cgcggcccgc
     3361 gccaaccgcg cgttcctgcg ccgcgccatc cgctacgcac tccagcaggg catacaccag
     3421 ttcctcgacc tcggctcggg gataccgacc gtgggcaacg tccacgacat cgcccaccac
     3481 atcgacatcg atgcacgggt tctctacgtc gatgtcgagc cggtagccgt ggcgcacgcc
     3541 agggccctgc tggataacga cccgcgggtc gatgtcatcc aggccgacat ctgctttccg
     3601 gatttcatcc tccagaaccc caccacgcag cggctgatcg acctcacccg tcccgtcgcc
     3661 gtcctcttcg tctcggtcct gcacttcatc cccggcgacg tcaacgccat cgtggaacca
     3721 ctccgcgccg cgatgccccc tggcagcgcc ctcgtcatct cccacgcgac ctccggcacg
     3781 gccacaagcc agaccgatga ggtgcagagg ctgtatcagc gcacgcctac cccacttcaa
     3841 ctgcgcgccc ccgcagaggt cgaggcgctg ttcggcgact tcgccatggt ccctgccgac
     3901 gcgccagcag cgaagtcggc gagcaacgca gcgctcgtcc ctgttgctcg gtggcgccct
     3961 gatcccgagg accagatcga gaggggacac gcgtcagcca gccccttcct caccggcttc
     4021 ctcgccgggg tcgggatgaa aggagcagca gctcgtgagt gaacctcctc ggctcgctat
     4081 ccgcagggaa ccatccctgc ccagtgccag ctgggtactg atgttcatcg gatccgcggg
     4141 acccaccagc ggcggcaagt gggcgtccgc ccaggttgcg tgccagcctg cggcaggctg
     4201 cgtccagacc acggaagggg cgggccgatg agttttgctc ggctgccgct gcgcgatgag
     4261 ttgttcctgc tcggccatga cgacgacgcc ggccacccgc acatccaccg ccaagccttg
     4321 gcgttggggc tggccggcgc ggtcctgatc gacctgtttc tcgccgggcg gatcgtcctc
     4381 gacccgaaca acgaccgttt gtccggagac cggtggctgc gcctgcacac cgatcaaccg
     4441 ctcggagacc tgatcgggga cagtgccatc ggcttcatcc gctatgggcg tacagcacca
     4501 ccggtgaagg cgttcctgcg cggcttcgcc gacgacctat acgagcgcac ccgcgccgga
     4561 ctcgtcgccg ccgggatcct ccggcaggtc actcgccggc gcctcggcgg ccttgcccgc
     4621 accgacacct acctcgccac cgacaccaag tgggcggtcg tcgcccgcgc acgcctgcgg
     4681 tacgtcgctc aaggccgtga gcagcccgac aaccacaccg ccgcactcgc cggactcgtc
     4741 gccaccctcg gcctcaccgg ccacctctac ctcaacgacg acagtacgac cgtgacggcg
     4801 cacctgaagg ccatcgccgg ccagcaccac cggtcggtgc gggacatcat cgccgccctc
     4861 gacgccgccg tcggtgacct cgccaccgca acgtaccggt gaagcgagac cacaaggaca
     4921 tctaatccga tggagagcct ggtgcacatt cgcgccgccc gttgggcaga caaggatctg
     4981 gtcgccctgc tgatcgccga cgccctgcac cccacaccgc tcgccgcgtg gctggtgccc
     5041 gacccagggc agaggtgcca ggtgctggcc gacgtcttcg cgatctgggt agaacatgcg
     5101 atgttcttcg gcgacatcca cctcaccgat gacctcaccg ccgccaccgt gggttttcac
     5161 cgttaccggc ccatcccgcc accggccaac taccggacca ggctcaccga cgccgccgga
     5221 ccaaacgccg accgcttcga cctgctggac acgctccttg ccgagaaaca gcccaccgaa
     5281 ccgcactacc acctggcgtt cctcgccgtc cgcaccgacg cccaacgggg cggctgtggc
     5341 gtcgcgctgc tggcccacca ccgcagccgc ctcgaccgca tcgacctgcc gtcctggacc
     5401 gctgttccct caggcaagga gcctctgctc gcccgatacg gctacacacc ccggccggcg
     5461 atcaccctgc cggacggccc gaccctgcag ccgatgcgcc gcaacgctcg ccacggcagc
     5521 agtgtcatgc cgatcaaccc ggcccgcccg gtcgacaacc gctggcaagg cttccatgtg
     5581 tagccccatc gctcccgtca ctaacagccc cacccgtgac atccacaggc agctgaccac
     5641 ccccgtcctg aaactggctc cgcgaatcat ggcctttcca agcagatacc ctccagacct
     5701 gatcgacgcc gtcgtccagc gcgtcacgga tgcccgccga gtcagggcat acggcgccgt
     5761 caccaccgtc gcccgtcaga tgaacctcga cccgcgccta gtccagaaat gggtcaccaa
     5821 agcgactgcc ccagtcgcgc tccagccatg caggccggcc gccgactcgt gcgagatgta
     5881 cctgccgccg ggactgctgc actgcaggtt ctgccagcag ccgatggctc acgccgagtc
     5941 gcacgactct gggcagggct accagtgcca gcagggttgc aggccccggc ccctggatag
     6001 cgtggccgtc gccgacacgg tcggtcgggc gatcctggcg cgcgccgctc ggatcatccc
     6061 gtcgaccagc acgccgatcc cgccacacct cgcagccgtc cacgcccacc gcgtcctcgc
     6121 ccgcgtcacc gtcggtgcca cccccagcga tgtcaccctc acctggcgcg ccacccctgt
     6181 tcccgaaccc ggccggttcg aggccgaacg cgcacagcgt gtcgccaccg cccgcaccct
     6241 ggtcctcagc gacccgctgc gcgcccggca actcctacac gccagcctca ccggcgtcga
     6301 ccccgccacc gcgcccgctc acccgctgca cgcggaagcc gccatcctcc tagccgaact
     6361 gcaactccgc ctcggccacc ccgccgacgc catggactgg gccacctacg cccgtgccag
     6421 cacggtccac ctccacgggc ccacccaccg gcgggccttg cacgccctcc acgtcctcgc
     6481 cgctgcccac tcgcgcggcg gacaccatca gcgcgcctac cacctctacc gggaactcac
     6541 cggccacctc accaaaaccg acggcccgca cgcccagcag accctcgccg tccaagcagc
     6601 caccgccctc atcctgcacg ccctcggcca ctgccaagcc gcccgcaccc tcctcgccga
     6661 caccatcacc acccaccggc gcgaacaccc cggccacccc gccaccgccc acatgacccg
     6721 gcacctgtct cgcatctggc gcgagtgcgc caccaacggc caccagcacc aggacgcctg
     6781 accgcccgcc tcgccctgat aggaggtccg ccgtgaccgc acgcccctcc cccggaacaa
     6841 ctcgtcggta ctacagccgc tcgggcggcg atgggtacga cgaaccactc ctgtcgtttg
     6901 gcgtccgtga catcgcagga accagcgcag cgctcccgcc ggcaccctgt cttcctgcat
     6961 tcgccgcacc aggcgtgccc cgaatgcagg agtgcctgtc cgacccgatg agaaggaagt
     7021 acgagtgacc cagatggctg agccacgcac cagtgccgac cgcgccgccc agctgcgcgc
     7081 cgcgctggtg gacacgctgc gcgatgaggg gatggtcacg agggctctcg tggaggcggc
     7141 ggtccgcgtg gtgccgcggg agcggttcat gccggccggt acgccgcttg aggtcgccta
     7201 cgcctacgac aactcagtgg tgaccaagcg cgatcagcac ggcatggcga tctcgtcggt
     7261 gtccgcggcg tacatccagg cgcggatgct ggaactggcc gagctgcgac ctggcatgac
     7321 ggtgctggag gtcggctcgg gcgggctgaa tgcggcctac atcgccgaga tcgtcgggcc
     7381 ggagggccgc gtggtgagca tcgacatcga cccggaggtc atcgaccggg ccgcgaccgc
     7441 gctggacgcc accggctaca gcagccgagt ccgtgtcctg gtcgccgacg ccgagcacgg
     7501 cgtgccggac gaggggccgt tcgacgcgat catcgtgacg gtcggggcgt gggacatcgc
     7561 cccggcctgg cttggccaac tggctccgga tggcgtgctc gttctgccgc tgatcatgaa
     7621 cggggtcacc cgcaccatcg ggttccggcg cgacggcgac cagctggtca gcacgtcggc
     7681 cgaagtggcc gggttcgtgc cgatgcaggg cgccggcagc cacgccaacc aggtgctcga
     7741 gctagccgat accaccggcg gcaaggtcaa gctttcgttc gactccggcg cacccccgga
     7801 tctgattcag ctcgatggcg tgctgaacgc cggcgcggcc gagtggtggt ctggcgtcac
     7861 ggtcagccac gggatctcct tcgccgacct gcacctgtgg ctcgcgtggt acctggatgg
     7921 gttctgccgc ctcgccgccg acgagggcag cgccctggct gcccggaagc gctggttgcc
     7981 gttcgcggtc gtacgcggag ccgggctcgc ctgcctcgtg ttgcgggacg cgatgcaggg
     8041 cgccggggcg gagttcggtg cccgcgccta cggacgcgac gggcaggtgg ccgccgccgc
     8101 gttgatcgaa cagatccagg cgtgggaccg agccgggcgg cacacgcctc cgacgttcgc
     8161 ctactggccc gccggcggcg accgctccca gattcgcgcc gacgccacgg tcatgaacaa
     8221 gacccacggc gtggtgacga tctcctggcc cacgagcagc tgactctggc ctcgggccag
     8281 cctcgctggg ccaggttgca acaacccagc cgcccaaacc catagggcga agcgggacgc
     8341 caagtccgcc agcccccgct acctgaaagg attcccatga cattgcaggt cgacgacgcc
     8401 accaccttgc gccaggccat ggtgggcacg ctgcgcgacg aaggtctgat caccaccgac
     8461 agcgtcgccg cggcgatgaa cgcggtgccc cggcacgagt tcgcacccgg cgaaccgctg
     8521 gagaaggtgt atcagaccaa cagcaccctg gtgcccaaga ttgacgctca ggggcgtcag
     8581 accagcgtgg tctcggcctc gcacattcag gccatccagc tagaactggc cgaggtacgg
     8641 ccgggcatga acgtgctgga gatcggctcg ggtggctaca acgccgccct gatcgcggag
     8701 gtcgtcgggc ggaccggttc ggtgacgacc gtggacatcg atgccgacgt cgtggaccgt
     8761 gcccgagcgg gtctgcgccg ggccgggtac gagcaggtca acgtcgtgct cgccgacgcc
     8821 gagcacggcg tggcacagca cgcgccgtat gaccggatca tcgtcacggt cggggcgtgg
     8881 gacatcccgc ccgcctggct cgatcagctc accccggacg gccggatcgt cgttcccctg
     8941 cgcttcgccg ggatcacccg catggtcgcc ttcgaccgta cccccggcat gtcggtgctg
     9001 acggccagca gctaccggct cggctcgttc gtgccgatgc agggcgacgg cgccgccagc
     9061 gagcagctga tcccggtcac gcccgacgtc gggctgcgcc ttgatcagaa cagcgctctc
     9121 acgttcgacg tgccggcgct gcgcaaggcg ctcaacacca agcccgtgga gagctggtcg
     9181 gacacgccgt tcgacatgcc ggacgagctg gagctgtacc tgctgaccag cgggccggaa
     9241 ctgccgatgc tgcacgccgc gcaggccgcg gtcgatcagg gcgtagtcaa ccgcacggta
     9301 cgcaacggca ccccgacgct ggtgcgcggc ggcagcttcg cctatcgcat caagcgggag
     9361 aatccgcaaa cggtcagcgg ctacgagacc ggtgtcatcg cccacgggcc ggaagccgag
     9421 caggtcggcg gcgagttgct cgccatgatc cgcacctggg cggactgcta ctaccggcgc
     9481 ggcgctgccc acatcaccta ccacccgaac accgccgaca ccagcgacct gaccgggtgg
     9541 cacagcacca agcgacacgg cgtcctcgcc atcgcctggt cctagaagac ttcggcgctc
     9601 acctcagcgg cccatgccgg ggggagcgtc ggggacccct atcactccaa ccagggaggt
     9661 tgtcatggcc cagctcgcca cggtccagcc cgacgtcgag ggcggcaccc tcgacgactt
     9721 cgatctcgac atcgagttca tcgaggccgg tggcaccgtc gagcacatca tcaagatgac
     9781 cgaggacaac tgcggcagca cctgcgcgtc ggcctgcacc agctgctgac cagccgcatc
     9841 cgctggtggc tcgctctgat ggccagccca aaccaggtgg gcaggccgta aggcgagcca
     9901 tcgacatcgg gtcaggagtg cccggcccgg ggagacctgc tctcgaaggt cgggcactcc
     9961 tcacccgcag acagatgatc acgcccatgg ggaggctggt gtgtaccgca gcgtgaacga
    10021 tgccttgatg ctccgggcgg ccgtacttcg cccgggccag ctcggcgcgt ggcctgacct
    10081 gaccggcagc gacacggcgg cccgttggcg gtcgtggctt gccgagacgt tgacgattcc
    10141 agggttcgcg gcagccttgg cccacgcgtc accggacctc gccgagcggg tcaccgccgc
    10201 aatcagcggc ggcctgtcgc aagctgacgc ccgccgggtg gtgctcgcgg tcatgcgcta
    10261 cctgctgcgc actaccaccc gtgccacacc gtacgggttg ttcgcgggcg ttgcccccgc
    10321 caccgcgagc cgcaccggac gcatgcgctg gggcactgca caccggcctt tcgctcgcct
    10381 tcaggcatcc tggctggccg ccgtcctcga tggcctggaa tccgacgtgc ggctgcgccc
    10441 gcatgtaatg gtgcgcgcca acaacctgct ggtcgagcgc agtgagaagc tggtgctgga
    10501 gtaccgcgcc gccacgaccg accccgcggg cgcgcccacg catctgcgca tcaaggccac
    10561 cgacatgatc cgcacggctc tcgcgctggc ggctgacccg atccgatggg ccgacctcac
    10621 cggcaagctg acggccgaat gtggggcgcc gcaggaaggc gcgcagcggc tgatcgagca
    10681 gatggtgacg cagcgtctgc tgttgacgag cctgcgcccg ccgtcgaccg agaccgaccc
    10741 cctggcgcat ctcgtggatc agctggagac tgccgcagcc gaaggcggcg aagtgggcga
    10801 gctacttgat ccgctgcgtc gcgttcgcga tctcaaggcc cgacacgacc gcgcaccgga
    10861 cggggccaca gctgctgccc gccgccggga cctcggcaga gcggccgccg tgatccagcc
    10921 cgggcaggcg gtcggggtgg atctgcggct ggactgcgac ctcgtggtgc cgacgacggt
    10981 gacggccgag gcgtgccgcg ccgctgccgc gctgacccgc ctcgcccgtc cgacatcgct
    11041 tcggtggcgg gactggcata cgcgtttctt gaaccggtac ggcctgcacg ccctcgtccc
    11101 ggttctggat gcgatcgatg ttcaggtggg cttcggctac ccggacggct tcaccggcga
    11161 gccggccaat gattcggccg cgttgaccga cagggaccgg aggctactcg ccttggcgca
    11221 acgtgccgcc ctgcgccgtg aacacgaggt cgacctcgac gacgtcctcc tggacaggct
    11281 ggccggcccg gctccgaccg agatcccgcc gaccgccgag ctcaccgtgc gcgtccacgc
    11341 cgactccctc caggccatcg ccggcggcaa cttcctgctg tcggtcgtac gggtgtcagc
    11401 gcaagccttc tccaccgcgg gccggttcct ggacatgttc ggcgagaccg actggcaccg
    11461 gatggcttcc tgcgccgtcg acagcccgcc agccagcgcc ggcgcgttgc tggcccagct
    11521 gtctgcggtc acccgctaca ccatcagcct ggacgtcaac cgcgcccccc aggtgctgcc
    11581 gcatctgatc cccgtcggcg agtatcacgc cccgtcgcag gccgcgatca gcttggacga
    11641 catcgcggta accgccgacc cgcaccgcct gtacctggtg tcgatctctc gccggcgggc
    11701 gctgcagccg gtcgcggtca acgcggtcga gccggtacgg cacgcccacc ctctggcccg
    11761 cttcctggcc gaagcgcccg tagccctcgc taccccgtgc tcacccgtgg agtgggggcc
    11821 agcggccaac ggcttgccgt tcctgcccgc gctgcggtac ggccggaccc tcttgagccc
    11881 cgcgcggtgg cacctgagcg ccgccgaact gcccgaccgg catgccggct ggcagcactg
    11941 gacccgagcg ctcaccgcct ggctcgaggc cacaggctgc cctaccgccg tctcgctcgg
    12001 tatcggcgac cagaccctcg gcctcgacct ggacaagccc gctcaccggg cgctgctacg
    12061 cgaccacctg acccgcaacc ccaccgccct actgcgtctc atccccgaag gcgacgcctg
    12121 gatcggcggg cgtccccacg agatcgtcat cccgttgacc gccaccaccc cgagaccacc
    12181 agcgccccgc ctcaccagcc ccctggtcga tgtccgaacc cacggcagcc tgcctggccg
    12241 cgaccaccac tacctgaaga tctacgcccg gcccgaggaa cagaccacca tccttaccgc
    12301 ccacctgcca cggcttgttg ggcaactccc gcctgcgggc gggtggtggt tcctgcgcca
    12361 cgccgacccc gagccgcacc tgcggctgcg tatcagcggc ctgcccatcg acgccatcac
    12421 cggctggacg caggaactga ccgacgccga cctgacccgg cgagtccagt gggacaccga
    12481 cttcggcgag cccggccgct tcggcagcct ggccgcgtac cacgcgacga cagccttgtt
    12541 cgcggcggac tccgcagccg cgctcgccca gctagccgtc accacgcgac gtcccacctt
    12601 gggctggcag gcgttgaccg ccgcgagcat ggtcgacctc gtcacggcgg tcatcggcga
    12661 cccacacgat gccctgcgat ggctgatagc ccgtacccgc ccgcaccggc cagcaccccc
    12721 acgagccgtc tacgaccagg ccattcgcct cgccaacccg tacgacccca ccgccgtggc
    12781 gtccctgccc ggctgcgaga acctgacgga ccgctgggcc gaacgccgcc gcaccgtggc
    12841 cgcctggcgc gaccgcctgc ccgccgtcag caccatcccg ccggccgagc tgctgcccga
    12901 cctgctgcac ctgcaccacg tccgcgtcgc cggggccgac ctcgacagcg aacgagcctg
    12961 cctgcacctc gcccgcgccg ccgcgctgag ctggacgaca aggagcacct cgtgaccgcc
    13021 ccgaccacca ccgctaaccg ctcggatgtg ctcgcggcgg tctgcgtcag actcgccagc
    13081 ccctccatcg tcggctcgtc gccggacggg cggacccggc cgcaatcgct ggccggaggc
    13141 gcggtgggca tcgccctgct gcacatcgag cgggccgtct ccggacacgg cgacgaagcc
    13201 accgcccacc tctggatacg cgccgcgggc agcgagccgg tcagcatcgg ccgcaactcc
    13261 gaccccttcc acggcgcccc cgcgctggcg ttcatgctgc acaccgcccg ccctctcggc
    13321 ggctaccgcc gcgccttcgc cagcctcaac gacgccacga tcaccctcac cagacaacgg
    13381 ctcgccgccg cccacgcccg catcgaccgc cgcgacccgc tgacgatgta cgagttcgac
    13441 ctcgtccacg gcctgaccgg gctcgggctc taccacctgc atgcccaccc cgagcacccc
    13501 atcagccgcg acgtgatgac ctacctggcc cgcatcaccg aacccctcga caacggctcc
    13561 acgcagccgc cgtggtggct gccatcgggg ctcggcggca caccacaccc agactttccc
    13621 cacgggcacg gcaacatcgg cgtagcccac ggcatcagcg ccgtcatcgc cctgctcgcc
    13681 cacgccatcc tccacggcca cgacaccccc gcagcccgca acgccctcgc cgccctatgc
    13741 gactggaccg accaccaccg ccaagacgac ccggccggaa catggtggcc cggctacgtc
    13801 acccccgaca ccaccccacg gcggcaccgg ccctcctggt gctacggcac ccccggcatc
    13861 gcccgcgctc agcaactcgc cgggctcgcc ctgcgagata cggcccgcca gcaacgggca
    13921 gaagacgcgc tgctcgccgt gctgcgagac gccgcccaac gcgcccggct gcccgagatc
    13981 ggcctctgcc acggcaaagc cggcctcctg cagactgcca gccgcttggc cgccgccagc
    14041 accgacccgc accgcgcggg tcagctcacc gccgagctgc ccggcctggc ggccgaactc
    14101 gccaaccagc tcgccagcca agcccaaggt gatccagagc tgctgaacgg cacggccggt
    14161 gccgtgctgg cgctgcagac cgccgtcacc ggcagcccgg cgaccagctg ggacaccttc
    14221 ctcgccctcg cctgaaccca agggaaacga acatgacgcc acccaaatgg cggcagacca
    14281 ccatcgcctt ccccgacccc cacgccgcag accaagtagc caccgcccag ctcgcgccga
    14341 tcctcgtcga cgccgaaacc cgccagctca tcaccacctg gttctacgtc cggaaagaca
    14401 cctggcggtt gcgctacctt cccgcctcca ccaccgccga ccactacttg accagccagc
    14461 tgacccgcct acgtcacaac cgccatatca gcgctgccgt tcccggaatc tacgagcccg
    14521 aggcccatgc cttcggcggc accagagcca tggacaccac ccaccagctc tggcatcacg
    14581 acagccgaca gctactcacc cccgacacca accacctagc cacgcggcag cccgagctgt
    14641 cgatcatgct caccgcggcc atgatgcgag ccgcaggcct tgactggtac gaacaaggcg
    14701 acgtctgggc ccgcgtcgcc aaccaccgag acccacccca gcccacgctc gtcaacaacc
    14761 tgctgcacgc ggtgaaacgg ctcctcacag ccgatccagc cagcctcacc caccaggggg
    14821 cgccgctggc cgccactcgc agctggttcg aggcttacat cgccgccggc gacaccctaa
    14881 accggctcaa tcagacagga cagttgcagc gcggcctccg cgcaaccctc gcccaccacg
    14941 tgatcttcgc ctggaaccgg cgcagcattc ccggcttaca ccaagcggcc atcgccaccg
    15001 ctgccaaaac catcatcttt ggacccaagc ccaccagccc cgccctcacc cccgacggtg
    15061 actcatgaac cccgccataa cccgtagatt cccgctgatc gcccggcccc gccccgtatg
    15121 cacatcccta ccccagcgca tcgccgacct agaggaacgt gccgacctcg cccaccacag
    15181 cggtgacgtg gccgccgcga ccgcggtgtt caacctcgcc gcgctcctag cctcggactg
    15241 tgacatgccc gacctggccc acacctggtg ccaccggctc gccaccgccg ccctcgacca
    15301 cggcagcgat ccccagcacg cactcgaacc catcgtgaac ctcgcccgcc tccacatccg
    15361 cgcgggcgac ggccccaccg cctggaccct gttggaaacc ctgttccagg ccatcgacac
    15421 ccgcactgac accctgatcg acggcctcac catccccgcc gcccgcctca ccgaggcacc
    15481 cggtgcccac accaagacac gaacctggct atggaccgtc ctgctcggca ccggcgccca
    15541 cgccctcgcc acggccggac ggtgggacga cgccagccac cgcctcaccc aatacaacgg
    15601 cgtcggcgca cgcatgctcg acggcaggca gatcagcgtc atcgcccacg ccacagcagg
    15661 ccgctaccgc caggcacgcg cgatgctaga cgccacccaa ccgggcgaac catgggaaga
    15721 cgccgtcact gcctgcctgc tcctgctgat gccagactcc gaccccacag acgaccaggc
    15781 gaacaaggcg ctgaccgcct accacgccct cggacccgcc aagcccggac tcaccgtctt
    15841 ccacacccgg ctcggcctca cccttctaga cgccctcgat aaagatcacc cagccgccga
    15901 gcagctcgcc gtcgaactga tccaacacgc cgctggcgac gggtacgccg cacgcgatct
    15961 actgactcat cccacttgcc ttgccgccgc ccaccatcaa cgggtcaatc agctcaagac
    16021 gctcgtatca acatgcggct tggacgcagg caccctgtcg gcggcgcagc taagagccct
    16081 gctccgcgcg ctcgacattg ccgaatcggt aattcgtgcc cccgcgagtg gtctaccagc
    16141 cgaaggtctc ccagatccac cgtcagaacc agacaactcc ttgcagaggg gctcgtccga
    16201 taccccgcgt tagttccccg gttcgttggc gcggcaactg aacgacgtcc tctctgggcg
    16261 cacagccctg ctcctgcccg cagccggtgg cactcttccg ccgatcgtct gtcctcaact
    16321 tcgtcaggga gcacagctac tccagtacgg atccggccga gatgctgcgg accgcgcacg
    16381 acgtgtacgc ctacatgttc cgcgaggagc acctgcagga ccctggcctg gacctcgtgc
    16441 ccgacgggac gctgctgatg ctgcgcgagt gtggaaccct gatggcgctc aatcgggtcg
    16501 aactcgacgg gcacatcagc aacgtttccc ctgcctggat gctgtgcgcc gtccgggtgg
    16561 tttacgatct ggacaaggcg accgctgaag tgctcgacga gctgtatcac ggcacctggt
    16621 tcaacgagtc gcgtcggcgc gagagcatcc tcgcgcacgc ggctctcggt ggcaggctgg
    16681 tccacgcctg ccagggcgct cccaacatgt ccggcagctg cgtcgtgccc ttcggcaccg
    16741 acgtcgaaac gatgcgccgc gagctggccg gcatgcgcgt gccctggatc gagcggaccc
    16801 tggccccgct gacctgacag aaccggtggc cgcgcggcgc ctgtgccgct tcaccctgcc
    16861 cgcggccacc gtcatccgaa ccggtggccg cgcgcagcct cccccgcgcc gcgcggggcc
    16921 accccaggac acctgaggag tggcagtggc gattgctagg gacaccagcg gccgggtcgt
    16981 gacggtccgg gacatgctcg acggcatcag cacctcgctg aagtacacca actaccagct
    17041 cgacaccgcc ggcgtcggtc acgagcccca cccgtggaac tggaccgagt ccgccggcca
    17101 cttccgcagc gtggtcacca aagaagccga actcgccgaa cacatcgccc gcaccatcga
    17161 ccgctgggtc aaagcgaacc aggacgccga cgccgcgaac ctggccgcga tgcgcaccgc
    17221 gtccaaggac ctcaaggccg ccgcccgcag cctggtcaac ctgggaaaga agatgcgcaa
    17281 cgtgcaggcc tgcctcgacg tcacccagtc gtaaccccat gtgtcgagtc cggccaccct
    17341 gccgtcgatc aggccatcgc ttttgacgaa tgtcgctgtc cgagtcgaac cgagatcgtg
    17401 ataactgagg gtgacgtttg gcgtccgagc cgacgcacgc accgcgacgg aagagggcgc
    17461 gaaccctgac ggctgcaaac tcgctggcgt gaaaactctc tgtcacggcg gacgacaccg
    17521 acgaatgcgg gttggccgac atcacctccc acgcgttcgt cgtgcgccgt gggaatcacg
    17581 ttgtcgcggc ggctggctac caacgttggc cggggctggt ggcccacatg tgcgtcctta
    17641 ctcagccgaa tcaacgtggg cgcgggctgg cgcgtgccgt tgcctccgca gcagtcgcgg
    17701 acggtttggc gaaccatctg ctgccgcagt ggcgggctcg accggacccg tcgcgccgcg
    17761 cgacgcgggc gctgggattc cgtcagcttg gcgctcagct gagcatccgg atcctgcgta
    17821 gcgcggatcg ctgatgtggg gcgttgcact tgatgatcga tttgcccgcc gctggcggca
    17881 ccagcgaagt ccggacccaa ttggctggca ggccgggagg acgcgcagaa ttgtcgtcat
    17941 ggagcccata cgcgaggccc cgacccttca tgaggtggtg cgcttcgcga cgcaactgcc
    18001 gcctgagcag gcgcgaaagc tgctcgcgag cgcgcatccc gcatcgctca agcccgaaga
    18061 ggatgctggg ggagcgccac ctgccttggt ctacgtgtcc tgggcccagt accttgcggg
    18121 caccacagca gaggaacgcc agacatggtg tcggctgaag gcacgcgcag cgaatcggac
    18181 gaggctcatg tccggggcac cggactacaa gatcaccgcc gcggatatct ggaacgtcct
    18241 tcaggccgct gaagggcgct gcgagcactg cggctccctt gccctcgaac atcggccgtc
    18301 gggccccgac gggcggccgg caccgtgggc gcacgtgggt cgacgcatcg gctccctcgg
    18361 tcaccggctc gcccgcttca acggcggttc taacaacatc gcaaacctgt gctggtcatg
    18421 cctgtggtgc aacacgtggc caaccgaacg acaccccggg gcgacagatc acggcgggca
    18481 ccaaccgacg gagtgactgc taacggcgag taggtcgcaa caccccttgg ccgacatcta
    18541 ggcgcacggt cagcggctac ctgttgactg gtggtacgac cgcagcccgg ccaggcttgg
    18601 tcgaggtgac cggtggggtc gctctcatcg cggctgccca ccgcaggttg gtgtggctct
    18661 catctggcgt gcgtcccgcc ggtcaccgcg gcggtgagag gctcaagagg ggactgccca
    18721 gctcaaggta gcgctgccct cccgtcgacg ttccatcgtc ggatcgaggg aggacacgat
    18781 ggcccaggtc atcatcggcg tggacccgca caagcgttcc gccaccatcg aaatcatcaa
    18841 cgcgcgagag aaagcgctcg ggcagggccg gttcggcacc gaccgcgacg gctaccaggc
    18901 gatgctcgcc gccggccgca agcacaagga ccgcctgtgg gcggtcgagg gctgcaacgg
    18961 catcggccgg cacgtcgctc aacgcctggt cgccgacggc gagaccgtcg tggacgtccc
    19021 cgcgaagctg tccgcccggg cccgcgtgtt cgccaccggc cagggccgca agaccgaccc
    19081 cgtcgacgcc cacagcgtcg ccgtggtcgc cctgcgcacc gaaggtctgc ggcaggtcgt
    19141 caccgacgac accacagtcg cgttacggct gctcgtcgac cgccgtgacc agctcggccg
    19201 ggcccgcacc gaagtggtct cccggctgca tcacctgcta ctggagttgg tgcccggcgg
    19261 cgcgaagaag gacctgtccg cccagcaggc ccgcgccctg ctgggcagcg tgcgcccgcg
    19321 tgacgtggtc ggcaagaccc gccggcggct cgcctccgag ctgatcggcg aactcgtcgt
    19381 catcgacaag aagatcaaaa ccgcgaaaca ggaactcacc gacctggtca acagcaccgg
    19441 aagtcggctg atgaatttga ccggcatcgg accgtccggc gcggcccgcc tgctcggcga
    19501 catcgcagac atcgcccggt tcaccagccg cgcccacttc gcctcgtgga acggcaccgc
    19561 accgatcgac gcctcgtccg gcgaccagaa ccggcaccgt ctctccagag ccgggaaccg
    19621 gcgcatcaac cgggcactgc acatcatggc catcgtccag ctacgccgtg acaccgaagg
    19681 ccgccgctac taccggcgca gactggccgc gggcaagacc ccgatggagg ccctacgggc
    19741 actgaaacgc cgcctgtccg acatcgtcta ccggcagatg gtcgccgacg ccaagctggt
    19801 caggacgggt ccgggaggac acgcgggggc gactctgcaa tccagcgcgg ccgatctgaa
    19861 ccccgagatc gacacttcgg aaaagtcact tcccggaccc gccacacccc agcctagaac
    19921 acccctcttg atcatcactt gacacagagg ggtgccagat cagggcgttt ccctcaatcg
    19981 atgcgtgcat gctgtggatg cctgttggtg gatacgctga ccgcgatggt ggaggctggg
    20041 agcggaaccg cgttggggcg gttgttggcg catcggtggc cggaggttgc cgcgacagcg
    20101 ggtgccctgc ggccggaact cgacgctgtg ctgaccggcg gcgcggccgc tccttcgttg
    20161 gtgcggcggc tggcgccgat gctcgggttg gacacggcgg atctgttcgt aatcgctggg
    20221 ctcgatctgc cgcaagatct ggtgcctgcc agtggtaccg ggccttggca tgtcgggacg
    20281 gtactggaaa tagcggccaa gttggcgccg cagtcgctgc gccggttaca cgagttcgtc
    20341 cggtcgctac ccgagcatcc gccggcgtgg ccgcccgtgc ggccgcgcta caggtacgcg
    20401 ctggggcctg gcgaggtgat gctgcggcta ctgcggaacc gcaatatcgg gccatacagc
    20461 ccgaagctgt tgtacttgat cggcggcggc ccgatggtgt cgcactctac ggtggccatg
    20521 ctgggacccg gccgtacgcg gctgacgccg cagtacgtga cctcgttcgc caccgtcctg
    20581 ggtatccctg acgacaactt ggccgccgtc gccggggttg ctgcggccac cgacccacgt
    20641 ctgcaccgca accgcgttga acttgcccgg ttggcctggg acgcccggcg gttgaccggc
    20701 gagcagctgt ctgaggtgct cgacctggcc gggcgcctgc ggtagctggg agcccgcaat
    20761 gatcccaccg ccgttcgacc acgtcggaac caagccaaat gtcctaacga tcaggatgca
    20821 ccggcgtggc cacgaacccg ggatcactct gccacagccg gtgcactgac atcgacagaa
    20881 gcggatacgc catccggtcg atgccggctt cttggtaacg gaacgccacg atggccgccc
    20941 gcccgttcct gtgggtctcg ctgaatccgc tagccggcga gcgggcggtt gaaggcccgg
    21001 acgtgcctcc gccgtctgca agatgtacct ggctgtgcac gttgaccgta cgctgatacc
    21061 accgcatcaa cgtcttcacg gcgatcaacg ggcaccatcc gcgctgtcac gggcctggcc
    21121 gtcgaccggg gcgactacat ggtgaatcac cgctcaacaa tcaccactat tgattcccag
    21181 gtcgctacgg catcaacccg ccgatctccc aggcggccga gagtcaggct gctaccatct
    21241 gcaccgcttc ggccacacgt ccggcgctta gcggtgggct tgtgggtggg gctgttggtt
    21301 ggatcacgcg gccggggggt tgccgcttcg ttcgttcgcg gacgatgttc ccccggccgt
    21361 tccaaccgct ggccaccgat gcaggcaggg gtaggcatgg aaatccggaa cattggtggc
    21421 cggccgcaca cggacatagc cggcgcagct gagctgaccg gacggtccga acagacggtg
    21481 cggctcaaga cgtcaccgaa gcagcgcgcc caagggtcag gctggcccgc gtcggtcaag
    21541 caggacaaga aggcgtggct tcccatcgac gagctggagc acgtccggga tgtcctccta
    21601 ccgcagatcg tggaatcctc ccgagcgcgg gtccatcatg tcgacctcaa cggcgacccc
    21661 gaggagctga tctccgccac cgggttccgg gagattctca ccatcacgca gggcgggtgg
    21721 gacaagtacg tcggaatgag caaggccgca tgggaccgcg gcgaggacgg ctaccttccc
    21781 atgcccgact gcgaagaacc cgcaccagta cagggatcta ctcgttactg gaagcgcaga
    21841 cgcgtgcagg aatggatcaa cacccggagc gggaaggtgc tcagcgccac gccgcccgat
    21901 ttgccaacca gtgactccta atgcagccgc tgaagcgaat ttgccgtagg caagacgact
    21961 gcttccggat gtagacccat tcgcaccact cgacgcccgc tagcccgccc ggtccggcag
    22021 ccgtctcgcc gcttgggctg aatcgacctt cggtcgatgg cctccagccg ggtcagcgtc
    22081 ccgccgctga accgcggcgc ctcgccggcg aggcaggctc cgggaagggg aagacagcgc
    22141 cgatccttcc cggcgacctg accccacagg gccaaccatg tgtggctgtg ggggtcaagc
    22201 cacaccccag gcttgacccc cacagccaca catggtcgat caaagatcag gccaccggga
    22261 aggctctctg acgcacatca cataaccggc tgcgccgact aattcaccat tcagcacgta
    22321 gagaaacatt agtagatcat gtgttattaa ctaccgacag tcacacactg accacgctgg
    22381 aatcccgcga attgaaacgg tctcaagtgg actctgcgag gttcgccatg tatcattaaa
    22441 tatgtgagga aggggacggc aacccccgcc ctcgcagcca acaccccaac cgaaagggat
    22501 taacggtgag caacgcgctc gacaccatcc ccctggccac ccggcacgcg acgctgccgg
    22561 acctgcaccg catcctcgac ctccagcagg cgcacaagct cgacatcgtc gctggcacgg
    22621 cgatgctgcg agccgaggcc ggacacctgc gcatcaccgg cgcggaaccc atcctcagcg
    22681 aatcgggtgt caccccctcc gacgggctct accggcccac cgaactgggc gacgcgggac
    22741 tcggcgaaaa gctcggcatc cccaccagct acctgcgcaa gacccgcgcg caggcactgc
    22801 acctctacga cgccaacatc aacggctggc tcgacctcag ccagggcaag cgctacctcg
    22861 cgcggtgcct gtccgacggt aacggcggcg gaatcctgcg cgccttcctc agcgacggat
    22921 acaagatcat cgacaacctc gatgtcctga tggccgtcct gtccggcatc cgcgaatcgg
    22981 gcatgagcgt caaattggat tgcgacctga gcgagcgccg gatggtcgtc cgggtgcact
    23041 ccgaggcgat caagagcctc gcccgcaacc tgctgcgcaa ctaccgcagc cccttcaccg
    23101 gagccaccgg cgcggacaac ccgaccgtct tcgccggtct cgtcttcacg aacagcgaga
    23161 caggctctgg cgcgttcact gtcactcccc gcatcgtcgt gcaggtctgc gacaacggcc
    23221 tcacgatcac caaagacgcc ctgcgagcgg tgcacctcgg cgcgaagatg gacgagggca
    23281 ccatccggtg gagcaacgac acccaccagg cgaacctcaa cctgatcggc aagcagaccc
    23341 gcgacgccgt gcgccgcttc ctcgacgtcc gctacgtgca gcgcaagatc gaagagatcg
    23401 aggagaaggc cggccgccgg gtccccgacc ccgaccacac catccgggtc gtcgcccagc
    23461 ggctgcggtt caccgaggac gagcagcggc tcatcctgaa ccacttcatc gacggcggcg
    23521 accgcacggc cggaggcatc atgcacgccg tcaccagcgc cgcgaagacc ctcaccgacc
    23581 cggacgccgc gtacgagatg gagggcgtcg gcatccgggc gatggaaatc gcggccacgc
    23641 tctgacccga gctccgggtg ccgctggcgc aacctgccag cggcacccgg acccagcgcc
    23701 cggccgcacg gctgaccgcg ttggcgcgca gcgagcacgc cgacgcgggc taccgcttcc
    23761 gcaccgcacg gccacagcag ccgggctaca acccgtccgc agccgtgcgc tgcaaaccca
    23821 ccgctgcgca ccttgggaga agcaatgccc ctgttcatcg ggttgcccca cggcgtgtcc
    23881 ctgccccgca accttgccga gcccgacgcc cgacacctcg tctccgtgct cgcccgcacc
    23941 taccaatgga ccgggccgct gttcggccgc gcggaagtcg aggcgtacct acgcgcccag
    24001 gccgacgacc ccggcagcct ccacgaccca gccctgaaca ccgaggactg gcgccgcgtc
    24061 cagaacactg ccgcatggaa gaacctcgcg gcaacagccc gccgtgccgt caccaccgcc
    24121 gacgtgatcg gccaggcact gcgccaagcc ggcttgtact gcgcccaatg tgactccccc
    24181 atcgccggtc cctcgaccgc caattggggg ctctgcccca cctgcctcaa cgccgccgac
    24241 atccgcgacc tgcaaacccg cccctgccca gccggcgacg gcgtaagccc tcaccgctgg
    24301 aacagcacca cctgcaccga atgcacgatg cccgcaccag ccgcccgccc ccgcctcacc
    24361 gccgtcgcca cagccgccta acagccgtgc gacgttcctc cgttcattgg caactccgca
    24421 gcgacccgac acggatccgc cagcgccgct gaacgcagcg gccccgaaac caccggtcag
    24481 gcccggacgg caacccgggc ctgaccggcc aaccaacaca cccacaaccg aagggagcac
    24541 accggtgctc acgatcaccg caaccggcgc gcagcccagc gcggaaaccg accagcccaa
    24601 cccggacgga ctacccgacc tgtcgaccac ccccaccgac ccggcggagg cagccgacac
    24661 cgagcacacc gtcgccaagc ccgccctgcc cggcggctac gaactgctgc ccatcaagca
    24721 gatcaagccc aaccccgaca acgtccgcga cgacgcccaa tccctgcccg gcatcgtgga
    24781 aaacctgcaa gaggacggcg ttcgcgggct gctcgccccg gtcatcgtca cgccgctagg
    24841 cgacgacacg tacctgatca tcgacggcga gcagcgatac tggtccgccg tcgaagccga
    24901 gcaggagtac atcccggcca tcgtccggga cgatctggcc ggcaaccgcg atcagatcat
    24961 cagcatgttg cggcaggtcc accgcaagga ccccaccgcc gcacaggtgt cccgaggcat
    25021 ccagcagctc gcccttgacg gcatgagcga cgaggagatc gcgcgcag
//
