LOCUS       NZ_CP084582            22115 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Micromonospora aurantiaca strain G9 chromosome, complete genome.
ACCESSION   NZ_CP084582
VERSION     NZ_CP084582.1
KEYWORDS    RefSeq.
SOURCE      Micromonospora aurantiaca
  ORGANISM  Micromonospora aurantiaca
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Micromonospora.
REFERENCE   1  (bases 1 to 7149079)
  AUTHORS   Schneider,B., Pfeiffer,F., Dyall-Smith,M. and Kunte,H.J.
  TITLE     Genome Sequence of Micromonospora aurantiaca Strain G9, a Member of
            a Bacterial Consortium Capable of Polyethylene Degradation
  JOURNAL   Microbiol Resour Announc 11 (5), e0114821 (2022)
   PUBMED   35389268
REFERENCE   2  (bases 1 to 7149079)
  AUTHORS   Schneider,B., Dyall-Smith,M., Pfeiffer,F. and Kunte,H.-J.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-OCT-2021) 4.1, BAM Bundesanstalt fuer
            Materialforschung und -pruefung, 12205 Berlin, Unter den Eichen 87,
            Berlin, Berlin 12205, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. SEPT-2021
            Assembly Name                     :: BAM_Maura_1.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 427.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 09:59:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,512
            CDSs (total)                      :: 6,447
            Genes (coding)                    :: 6,372
            CDSs (with protein)               :: 6,372
            Genes (RNA)                       :: 65
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 75
            CDSs (without protein)            :: 75
            Pseudo Genes (ambiguous residues) :: 0 of 75
            Pseudo Genes (frameshifted)       :: 25 of 75
            Pseudo Genes (incomplete)         :: 59 of 75
            Pseudo Genes (internal stop)      :: 6 of 75
            Pseudo Genes (multiple problems)  :: 15 of 75
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:21:19
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4134875
            Orig. end                         :: 4156990
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP084582.1.
            Bacteria and source DNA available from BAM, FB 4.1, Hans Joerg
            Kunte, Unter den Eichen 87, 12205 Berlin, Germany.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22115
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="13"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..22115
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22115
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:12115]"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12115
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     gene            702..1559
                     /locus_tag="LF814_RS18735"
                     /old_locus_tag="LF814_18745"
     CDS             702..1559
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013286898.1"
                     /locus_tag="LF814_RS18735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_18745"
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_013286898.1"
                     /transl_table=11
                     /translation="MITTAVVESTAGRTRSGLGRALDIVNIIAERAPETLGVSTIAREL
                     GLPKAVAHRILKELVADNFLTFNEETKRYRLGTGALAVGLAALRALDVPDIARRYLVRL
                     VRDTGETATLSVRQGWSRVYIDQVLSPHEVRMSVSLGTSHALHSGSSSKAILAALPDAE
                     VDDYLGHHPLDAVTPATITSTAKLRADLARIRRQGYAVSMGERQNGAGSVAAAVRYATG
                     QVFGSISLCGPQNRFTPEVCAAHGALVAAAAAEISAELGFRPPAQRVAGRTGQEQNWGG
                     GTGE"
     gene            1552..2751
                     /locus_tag="LF814_RS18740"
                     /old_locus_tag="LF814_18750"
     CDS             1552..2751
                     /EC_number="2.8.3.-"
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1189: L-carnitine dehydratase/bile acid-inducible"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013476394.1"
                     /locus_tag="LF814_RS18740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_18750"
                     /product="CoA transferase"
                     /protein_id="WP_013286899.1"
                     /transl_table=11
                     /translation="MSDGPLTGLRVLDVSTILAGPLCCQILGDYGADVIKIEHPTMGDS
                     MRGHGKAKDGHPLWWKEISRNKRLVGLNLSAPEGAALLLRLAERADVLVENFRPGTLER
                     WGVGPEELHRVNPGLVIARITGFGQTGPYASRAGFGTLAEAMSGFAHLTGTADGPPTLP
                     AFGLADSICGIATSSAVMMALWHRERSGGRGQVVDMSLLEPIMTAVGPGPTVYDQLGVV
                     EQRQGNRSTNNAPRNTYQTKDGSWVAISTSAQAIAERVLRLVGHPEVIDEPWFRTGVGR
                     VAHADLLDEYVGSWIAERTRDEVAAAFAEAGAAVAPVYSAKDIVEDPHVRATEMITTVD
                     DPDLGPMRMHNVMWRMSETPGRIRFTGRSPGADTDALLVEELGCDPAEIADLKARGVVA
                     "
     gene            2783..3622
                     /locus_tag="LF814_RS18745"
                     /old_locus_tag="LF814_18755"
     CDS             2783..3622
                     /EC_number="3.5.-.-"
                     /GO_function="GO:0016812 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds, in cyclic amides
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013476393.1"
                     /locus_tag="LF814_RS18745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_18755"
                     /product="cyclase family protein"
                     /protein_id="WP_151011083.1"
                     /transl_table=11
                     /translation="MGTTARTADRLLDAVQAGVTIYDLGRRLTVGMPQSPNHPAFGLTL
                     PRRHGDMVRADGGSAANDLLVMGTHVGTHVDALAHVSQDGRLHGGADAADAQVGGRFDE
                     LGVHTVAPMVRRGVLLDVPAALGVETCEPGYEITPADLDAAVSRQGTPVGPGDVVLIRS
                     GWGRLFDHEDRGVYVGKDSGVPGVGADGATWLAQRQVHAAGADTIAFECLPPGKGHSSL
                     PAHRILLVEHGVYLIETMALEELARDEVHEFTFVMAPLPLYGATGSPVRPLAVISRG"
     gene            3615..5021
                     /locus_tag="LF814_RS18750"
                     /old_locus_tag="LF814_18760"
     CDS             3615..5021
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013286901.1"
                     /locus_tag="LF814_RS18750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_18760"
                     /product="MmgE/PrpD family protein"
                     /protein_id="WP_013476392.1"
                     /transl_table=11
                     /translation="MAEPTLGRHLATFAADTAAETLPDEVVASVRARVLDVLGLCVAAR
                     PLPTSQAALAYVEEQGGRGQATVVGLDEKAPAALAAFANGVLAHSLDYDDTHLPSVLHP
                     SASVVPAALAAAEASGASGRETVAAIAVGLEVCVRLGMAGYDPAAGNSVFFEHGQHATS
                     ICGTLGGAVAAARLLKLDADGALDALGVSASMAAGLIESNRNGGTVKRIHCGWAAHAAV
                     SAAQLARHGVTGPPTVLEGRFGFFQAFLRGEFDGDEIVRGLGTDWAVPGIFFKPYPANH
                     FTHAAIDAAIALRERGLPLDEIESITLGVPTPTVRTIGQPIERKRAPQTGYEAQFSGPY
                     AVVAGLIGGGGLGVDLADFTDALAHDPQRRALMALVDVVGDERCDAIFPHQFPAVLRVV
                     TRDGREWVQEVLANRGGPQRPLSDAELAVKFRTNAAALPEATADRITEEVHRLDRAPDV
                     HGLMGLINRR"
     gene            5044..6507
                     /locus_tag="LF814_RS18755"
                     /old_locus_tag="LF814_18765"
     CDS             5044..6507
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013476391.1"
                     /locus_tag="LF814_RS18755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_18765"
                     /product="dihydroorotase family protein"
                     /protein_id="WP_151011079.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 2.5e-11, bitscore:
                     41.9, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTYDLLLTNVRVVRHDRPEPELMDIGVTDGRISRVAPQIDRAEA
                     AQVVDGGGRLAFPGVVDAHQHWGIYNPLSEDAVSESRASVQGGVTTALNYMRTGQYYLN
                     RGGRYADFFPEVLSATEGRSYIDYGFHLAPMSREHIGEVPSLVEEHGVTSFKIFMFYGS
                     HGLHGRSTDQNSFLMIPEGERYDYAHFEFVMRGVQAARERFPELADEISLSLHCETAEI
                     MSAYTKQVEQDGTLRGLEAYHASRPPHSEGLAVSIASYLAHETGLPKINLLHLTSEKAV
                     DAALRMARAFPHIDFRREVTIGHLVADIDTAHGLGGKVNPPLRPRADVEALWGYVLDGK
                     IDWVVSDHACCKDEVKFGEPRDDIFVAKSGFGGAEYLLPGLVTEGNRRGLSYQRVAELT
                     SWNPAQRFGLRNKGALLQGYDADICLVDPDSTWTVRAEDSESTQEYTPFEGFELTARVT
                     DTFVRGQHVLVDGKVTGEPAGRYLARPQR"
     gene            6520..7380
                     /locus_tag="LF814_RS18760"
                     /old_locus_tag="LF814_18770"
     CDS             6520..7380
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013286903.1"
                     /locus_tag="LF814_RS18760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_18770"
                     /product="CoA ester lyase"
                     /protein_id="WP_151011076.1"
                     /transl_table=11
                     /translation="MAAVARSYLYVPGDRADLLDKAAGRGADALVLDLEDAVTPARKAH
                     ARETVAGYLGAAAPAGPELWVRINSDQVEADVEVLSPAAAGVWVPKAEPDLLAEVDAAL
                     TRVQRRLGPDAPAFRVVALIETARGVLTAPQVAAAARVLRLGLGEADLAGELGLQPGPE
                     RAEFAPIRSQVVVASAAAGITPPVGPVETTLRDPERLEQTTRALLRQGFRARSAIHPGQ
                     IATVNEVFTPTEAEVASARAVLEALERAERGGSGVATDAGGRLLDRAVVRAAAEVVRRA
                     EASAG"
     misc_feature    complement(6566..6581)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.16"
                     /tool="antismash"
     gene            complement(7439..8074)
                     /locus_tag="LF814_RS18765"
                     /old_locus_tag="LF814_18775"
     CDS             complement(7439..8074)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013286904.1"
                     /locus_tag="LF814_RS18765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_18775"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_013286904.1"
                     /transl_table=11
                     /translation="MGRATQSAYESIKTRILGGAYEPGKKLSEEDLAAAVGVSRTPVRE
                     ALRRLHAEGLVDWEANRGATVPAWREQDLEEIFELRALLEGYGAELAATRITPEEIARL
                     RELCAEMEGYAAGQRRDRADRIAVCNAQFHEIILGAGRNRRLSALLGAVVQTPLVNRTF
                     RRYDEAAMARSMSHHRELIDAFEARDRAWAGSVMRAHILAARATLGTP"
     gene            complement(8104..8853)
                     /locus_tag="LF814_RS18770"
                     /old_locus_tag="LF814_18780"
     CDS             complement(8104..8853)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013286905.1"
                     /locus_tag="LF814_RS18770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_18780"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_013286905.1"
                     /sec_met_domain="adh_short_C2 (E-value: 2.8e-35, bitscore:
                     121.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRGRVAVVTGAGSGIGLAVARRLADEGAEVVSADLDVSACVGVPV
                     TADLGTPAGVAAVVREVTSRYGGADVLVNNVALAPYRDAFTDIDDAAWQRTWDVNVMSC
                     VRLCRALVPLMVERGGGSVVTIGSEAARHPKPHMLDYAVSKAALLSLAKGLALEYGSRG
                     VRVNTVAPGPTRTATMDAYLESVALRLGIDVSAAADHVVHELRRLPLGRMNEPEDVAEV
                     VLFLAGDRSRQVTGSEYAVNGGSTASM"
     gene            complement(8850..10004)
                     /locus_tag="LF814_RS18775"
                     /old_locus_tag="LF814_18785"
     CDS             complement(8850..10004)
                     /EC_number="2.8.3.-"
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1189: L-carnitine dehydratase/bile acid-inducible"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013286906.1"
                     /locus_tag="LF814_RS18775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_18785"
                     /product="CoA transferase"
                     /protein_id="WP_151011072.1"
                     /transl_table=11
                     /translation="MTGPLTGLRVLDLTSTFSGPYCTLMLADLGAEVIKVEPPGGDIAR
                     QLGAARTPGMAAVFLNMNRGKKSVLLDLKAPADRAAFDRLVPTVDVLVHNMRPAAAARL
                     ALTYDDVRALHPAIVYCAIPGFRGTSRHADRPAYDDVIQGASGIARLQSVNQDQPGYVV
                     TPLADKITGLTASTAVLAALRHRDATGEGQRVEVPMYDTMVAFGLLEQLDGWTFDPPIG
                     PPLYPRTAAPNRRPYATADGHLCVLIYTGRQWERFLTLVGRADLLRHPDYDTVGKRIAN
                     ADGLYRVVAEVLRGRTTAEWLTELSAIDVPCAPLAGYEEILREEEEAGSGLVSIVEHPV
                     AGRLRSVASPIVMSGSPLPAGRLAPTLGEHTDEVLAGGTEGRSG"
     gene            complement(10001..10732)
                     /locus_tag="LF814_RS18780"
                     /old_locus_tag="LF814_18790"
     CDS             complement(10001..10732)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012885.4"
                     /locus_tag="LF814_RS18780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_18790"
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="WP_225319489.1"
                     /sec_met_domain="HMGL-like (E-value: 2.5e-36, bitscore:
                     124.2, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPKLADADALAALVRDEPGLASIGLVMNGRGLDRAVAAGVTEVNF
                     VVVATDTFCRRNQGTTTAEAVAQVRRLLPRAREQGLRASVTVGAAFGCPFEGETPPERV
                     LRVVDDLASVAPDEVALADTIGVAVPSQVERLFTAVRERIGASLRGHFHNTRNLGLANV
                     LAAVGAGARAIDASVGGIGGCPFAPAATGNVATEDVVYALERSGTATGVSQEAAIGNAR
                     WLGEVFGAELPGMLSRAGGFP"
     gene            10781..12115
                     /locus_tag="LF814_RS18785"
                     /old_locus_tag="LF814_18795"
     CDS             10781..12115
                     /NRPS_PKS="Domain: AMP-binding (97-296). E-value: 1.8e-17.
                     Score: 54.9. Matches aSDomain:
                     nrpspksdomains_LF814_RS18785_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013476387.1"
                     /locus_tag="LF814_RS18785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_18795"
                     /product="AMP-binding protein"
                     /protein_id="WP_013476387.1"
                     /sec_met_domain="AMP-binding (E-value: 9.5e-12, bitscore:
                     42.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGPFSERHWHEAETWPRERLAAYQLTRLKAQLSYVYAASDFYRT
                     RWDALGFHPGDVRELADLRRLPLVGKADYVADLAAHPPWGSAVAAPVADRRRVHFSSGT
                     TSNPTPVLWTAHDLDRWADLYARAAYSQGVRDTDVYQCLFSYAWFVGGLGATAGYQRIG
                     VTLLPAGSGDTQRQIDTIFRYGTTAVGGTPSFMLHLAETAERAGTPLRDSPVRRIQVGG
                     EPGAGVPATRAHIEQRWGAKCFDGYGSLEFQPIAWECEEQAGGHLAEDFAYAEVLDPYT
                     HEPVPDGAPGLLVLTHLDKRASPLVRWATGDVVVRDSTACPCGRTLARLPGGVVGRADD
                     MLVVRGVNLFPSAVEQVVRATPGACGEYLIVLDDDVTDPATGYLTGIKLRVEVTGDGQR
                     VARELAHAVRAELTVRAVVETVPEGTLPRSTHKSKRVVRADRKVP"
     aSDomain        11072..11668
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_LF814_RS18785_AMP-binding.1"
                     /evalue="1.80E-17"
                     /label="LF814_RS18785_AMP-binding.1"
                     /locus_tag="LF814_RS18785"
                     /protein_end="296"
                     /protein_start="97"
                     /score="54.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="VHFSSGTTSNPTPVLWTAHDLDRWADLYARAAYSQGVRDTDVYQC
                     LFSYAWFVGGLGATAGYQRIGVTLLPAGSGDTQRQIDTIFRYGTTAVGGTPSFMLHLAE
                     TAERAGTPLRDSPVRRIQVGGEPGAGVPATRAHIEQRWGAKCFDGYGSLEFQPIAWECE
                     EQAGGHLAEDFAYAEVLDPYTHEPVPDGAPGLLVLT"
     gene            12115..13281
                     /locus_tag="LF814_RS18790"
                     /old_locus_tag="LF814_18800"
     CDS             12115..13281
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006635 - fatty acid beta-oxidation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1124: acetyl-CoA acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013476386.1"
                     /locus_tag="LF814_RS18790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_18800"
                     /product="thiolase family protein"
                     /protein_id="WP_151011069.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 1.5e-07, bitscore:
                     29.8, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDRQAFLVGAVRTPHGRYGGALRDVRVVRLGGLAGAEALERAGVP
                     AEAVDETVVANCRQAGNGPNPGRQISLAAGVPVPTPAQTINMACASGLKAVQLAHRSVR
                     SGEADVALAVAAESMSTMPYLAPYTLRWDGVRRGDVLLQDGWRDGGTDPICGMSMGETA
                     EKVAREFGVSRADQDAWSARSHQRLARAWESGAMALEVLPLDELDRDETVRPDTTPERL
                     ARLRPSFTDGGTVTAGNASQMADGAAAVVVAGGEAVRRYGLTPLGRIVGFAAVGVDPTM
                     MGVGPAEAIPLALHRAGLTAADVDLFEINEAFGAQIVQNVRALGLDEERVNVNGGGIAL
                     GHPTGQSGARLIVSLLHELARRDGRYGVASLCVGGGQGIAAVIERVTR"
     gene            13278..14681
                     /locus_tag="LF814_RS18795"
                     /old_locus_tag="LF814_18805"
     CDS             13278..14681
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /GO_process="GO:0006631 - fatty acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013286925.1"
                     /locus_tag="LF814_RS18795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_18805"
                     /product="3-hydroxyacyl-CoA dehydrogenase NAD-binding
                     domain-containing protein"
                     /protein_id="WP_151011066.1"
                     /transl_table=11
                     /translation="MIAVVVGLGPMGRGIAQVLAAAGHTVRVVDATAELGRAGLERIRA
                     DGATGDLGAAADVETALAGADVLIEAIVEDMAAKRDLLARVAAAGGPDLLVASNTSSLS
                     VNEMGRAFGAPERLLGLHFFNPPTRMRLVEVIVGAATHDATVRRALALVESLGKTAVVC
                     RDSPNFIVNRVCRPLYYEAQLLLAQGVEAAVVDAVARGALGHPMGPLQLLDFTGLHTHL
                     ASSETALREFGDPRYRPIPQVRGLVRAGLTGKAAGRGFYDYATEPPRDANARVVRRPGA
                     PNGPAARVVSLGAPTPQRVAELARLAARQNVVLDSSDAGWAEVLPADVGWIRLHRRADD
                     AVFAEVVEDPVAGVAVPGFVDRLLDHLGASSVRVPALPGLVGDRLAHCLVNEAATVVEE
                     GTATADDVDVALRLAMNHPRGPFQTLRAAGAGTVYEALRSMADAFGDPRYRPAQLLRRQ
                     AIGEARAAR"
     gene            14678..15508
                     /locus_tag="LF814_RS18800"
                     /old_locus_tag="LF814_18810"
     CDS             14678..15508
                     /NRPS_PKS="Domain: PKS_KR (22-146). E-value: 5.8e-08.
                     Score: 24.8. Matches aSDomain:
                     nrpspksdomains_LF814_RS18800_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013286926.1"
                     /locus_tag="LF814_RS18800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_18810"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_151011063.1"
                     /transl_table=11
                     /translation="MTRGDDTGVAVLRAGVLTGRRAVVTGAGSGIGRAVAIRLAELGAH
                     VTGLGRHADTLAATGEAITGEAATGGGRYTYAVCDVRDHDRAAATLAEAGEAHGIDLLV
                     NNAGGQFFAPATRISAGGWAAVVDLNLTSVFHLTTAAYPYLRRTRGAVVNMSLSGVERG
                     GQGMAHAVAARAGVLGLTRTLALEWAADGIRLNCLGPGTVLTAALDAEADRHVRDNLVD
                     RATPLRRPTRAEEVAELVAFLAGPAAAMMTGQLIQLDGGAHLGPGLHMLAEAYR"
     aSDomain        14744..15115
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_LF814_RS18800_PKS_KR.1"
                     /evalue="5.80E-08"
                     /label="LF814_RS18800_PKS_KR.1"
                     /locus_tag="LF814_RS18800"
                     /protein_end="146"
                     /protein_start="22"
                     /score="24.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VVTGAGSGIGRAVAIRLAELGAHVTGLGRHADTLAATGEAITGEA
                     ATGGGRYTYAVCDVRDHDRAAATLAEAGEAHGIDLLVNNAGGQFFAPATRISAGGWAAV
                     VDLNLTSVFHLTTAAYPYLR"
     gene            15505..16299
                     /locus_tag="LF814_RS18805"
                     /old_locus_tag="LF814_18815"
     CDS             15505..16299
                     /EC_number="2.8.3.-"
                     /GO_function="GO:0008410 - CoA-transferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013286927.1"
                     /locus_tag="LF814_RS18805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_18815"
                     /product="CoA-transferase"
                     /protein_id="WP_151011060.1"
                     /transl_table=11
                     /translation="MSRALADVVAEHVRPGRRVYLGNFGAQLFAVGHEMIRQRIRDVDV
                     VIASGGLLMDQLLGAGVLRSATYGHCWSPVGPAPAWNFRRAAQDGDTRVTLHELSLGLL
                     TAALTAGAWRVPFMPVPDLPGTGYLDEDWSRGRLSSVDSAFGPARVVRAERPDVAFVHV
                     DLADADGNGMIRGPLGEVLVAAQAARRTVLVAEQVTDAETVRAAGISIPGLLVDAVVES
                     PGAVHPDGAVGRYPRDVEAYQRYARRSATADGFRRWLAEEVL"
     gene            16296..17024
                     /locus_tag="LF814_RS18810"
                     /old_locus_tag="LF814_18820"
     CDS             16296..17024
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013476382.1"
                     /locus_tag="LF814_RS18810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_18820"
                     /product="co-chaperone HscB"
                     /protein_id="WP_013476382.1"
                     /transl_table=11
                     /translation="MTTADFLVRAAREFRRGGWVFTGFHWPVLAGHCAYALPGEPFSQV
                     FEAGASAHRPGADVPTSTTDYPAYAGGFGWLGGTADVLLAMGHRFDRVVLDAGNVDLRG
                     RINSSYLGPRERPTVRLPGGGGAADIAAAARELVLLHGARDPRRIVCAVEHVTAAPAPD
                     ALVRLHTRWGVVRLGADPRLEEVTADGEVLRAHLAALGVPVDGAAPRPPVTAAERAAAV
                     GVLRRAAVRGYSVAKGTDRG"
     gene            17021..19135
                     /locus_tag="LF814_RS18815"
                     /old_locus_tag="LF814_18825"
     CDS             17021..19135
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013286929.1"
                     /locus_tag="LF814_RS18815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_18825"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_151011057.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 5.2e-20, bitscore:
                     70.8, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 7e-22, bitscore:
                     76.0, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1e-14, bitscore:
                     53.5, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDDDLDELRRQVRKLVGEWRDGDRFRPVCDAWLRSYDTEFSRAL
                     ADRGWIGLTWPREYGGQARSNRARLVVTEELLRAGAPVAAHWIADRQIGPAVLRYGSPA
                     LRERYLPAIAAGAVTFCLGMSETESGSDLASVRTTARPDGDGWRLTGGKIWTSHAHRST
                     HAYVLCRTGTGGDRHEGLTELIVDMSAPGVTVRPIVDLRGEHHFNEVVFDDVRVPGDHV
                     LGTAGNGWTQVTEQLSFERGGMERVLSTYPLLAATVDACAARRDADAALGEALARLAGL
                     RGLAWRIAGELDAGQAPVHAAAVLKDLGTEFEADVNEIARTVLDVEPDPDGDGPAGLLA
                     QGLLAAPGFSIRGGTTEVLRTIIAKGAARAPRRGGDELRELTDDVLGGHGGDPDGLPTL
                     WSTLHGLGWTGVSVPEDAGGSGGTLADLAALVRGLGRHGVSLPLAGTVLAARQLAAAGR
                     GLPEGVATVVAGDGLAVAGGRLRGTAARVPWAAAARTLLVYAGDEAFVVPADHPGVRVT
                     PGRNLAAEPRDDVVFDVPVTGDMRLTGVAPAGAVRAEAALLTAAALTGALETAVEHTRQ
                     HVTTREQFGRPLLAFQAVGQTLARMTAHTLLAGTALDAALAGPDPLRVAAARVLTGRAA
                     TIVARGAHQLHGAMGVTREHPLHLSTRRLWSWRDENGTQQFWAATLGAALVPRGSAGVW
                     SWLTDQEAES"
     gene            19132..19881
                     /locus_tag="LF814_RS18820"
                     /old_locus_tag="LF814_18830"
     CDS             19132..19881
                     /EC_number="4.2.1.17"
                     /NRPS_PKS="Domain: ECH (13-248). E-value: 1.1e-47. Score:
                     154.4. Matches aSDomain:
                     nrpspksdomains_LF814_RS18820_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013286930.1"
                     /locus_tag="LF814_RS18820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_18830"
                     /product="enoyl-CoA hydratase"
                     /protein_id="WP_013286930.1"
                     /transl_table=11
                     /translation="MSKVELHNADGRWTLTLNDPDRRNAIDAEMRDALGDAIAEVAADR
                     HARTLVVTGAGTAFCAGADLPAMFGEPGRGVAEIRADLHRVYDSFLRVRALPIPTIAAV
                     QGPAVGAGLNLALACDTRIVGPKAKLIASFTKLGLHPGGGCTWFLTRALGPERALQLLL
                     DGGSVDGPEAVRVGLAATLADDPLAAAHERAERWAALDPALARDIKTSVRTAETAGFAA
                     ALEFESWAQASSATGPAIQEAVAAFRR"
     aSDomain        19171..19875
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_LF814_RS18820_ECH.1"
                     /evalue="1.10E-47"
                     /label="LF814_RS18820_ECH.1"
                     /locus_tag="LF814_RS18820"
                     /protein_end="248"
                     /protein_start="13"
                     /score="154.4"
                     /tool="antismash"
                     /translation="TLTLNDPDRRNAIDAEMRDALGDAIAEVAADRHARTLVVTGAGTA
                     FCAGADLPAMFGEPGRGVAEIRADLHRVYDSFLRVRALPIPTIAAVQGPAVGAGLNLAL
                     ACDTRIVGPKAKLIASFTKLGLHPGGGCTWFLTRALGPERALQLLLDGGSVDGPEAVRV
                     GLAATLADDPLAAAHERAERWAALDPALARDIKTSVRTAETAGFAAALEFESWAQASSA
                     TGPAIQEAVAAFR"
     gene            complement(19952..20851)
                     /locus_tag="LF814_RS18825"
                     /old_locus_tag="LF814_18835"
     CDS             complement(19952..20851)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013286931.1"
                     /locus_tag="LF814_RS18825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_18835"
                     /product="ROK family protein"
                     /protein_id="WP_151011054.1"
                     /transl_table=11
                     /translation="MERPANPRLLGIDFGGTKMAIGVGDTDGRLLVSERLPTIAERGAQ
                     QALTRALDRACELAEQTGGTIVAAGIASPGVVHDDGIELAPNVPGWEQLRLAEAVRAHL
                     NLAHVRVTNDLKAAAYAELRLGALRDADPGLVVGLGTGVAAAVTVNGEVLPGRHGAAGE
                     IAYGLTDLSWPPRLEPMLEATFSGRALDELAQRLGVDGRSAGLCAAAEQPGPVREQLRL
                     RVDELARQLVTCCLLLDPQRIVLVGSVAGNDLVRELLTERLTHTLPYPPEIVLSDFAQD
                     AALLGALVMATEAQPAVV"
     misc_feature    20879..20892
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.11"
                     /tool="antismash"
     misc_feature    21543..21557
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.52"
                     /tool="antismash"
     misc_feature    21768..21782
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
ORIGIN
        1 agtacgtgcc gaccgggctg acgtcgctgg tggtggccgg catgccgctg tgggtgctgg
       61 tgttgcggct ggcggtcggt ccacggccgt cggcgctcgc ggcggtgggc gtactgggcg
      121 gggtggccgg gctggcgctg ctgttctcgg tgccgacgaa gggatggcac ctcggcggga
      181 tgctgctgct ggtggtctcc acgatggtct gggcgctggg ctcgacgctg tcgcagcggc
      241 tgcacatgcc ggccgatcac ctggtcggca ccggctggca gatgctcgtc ggcggcgtcg
      301 cggtggcggt ggcgagcgtg gtcagcggtg agctgggacg gttcgacctc gccggcgtga
      361 ccggccggtc ctggctggcg tggacctacc tgatgctggt gtgcacagtg gtcggcttca
      421 gcgtctacac gtggttgctg cgcaacgcgc cgatccagct cgcgtccacc tacgcgtacg
      481 tcaacccggt ggtggcggtc ctgctcggca tgatggtgct ggatgaatcg ttgtccggac
      541 gacaggtgct cgccggtgcc gtggtgctcg cctcggtggc gctcgtcatc gcgcgggagc
      601 gaccccggca ggccgacggc ctcccgcccg ggaagacccc cgtcgcaccc gcctgacgcc
      661 cggcgacccc acgcacgtac gtcgacagtg gaggaacaga gatgatcacg acagcggtcg
      721 tcgagagcac cgccggccgg acccgttccg gtctgggccg cgccctcgac atcgtcaaca
      781 tcatcgccga acgggcaccg gagaccctcg gcgtgtcgac gatcgcgcgg gaactgggtc
      841 tgccgaaggc ggtcgcgcac cgcatcctca aggagctggt ggccgacaac ttcctcacct
      901 tcaacgagga gaccaagcgg taccggctcg gcaccggcgc gctcgcggtg ggcctggccg
      961 cgctgcgcgc gctggacgtg ccggacatcg cgcgccgcta cctggtccgg ctggtgcgcg
     1021 acaccggcga gaccgccacg ctgtcggtgc ggcagggctg gtcacgcgtc tacatcgacc
     1081 aggtgctgtc gccgcacgag gtccggatgt cggtgtccct gggcaccagc cacgcgctgc
     1141 actccgggtc gtcgtcgaag gcgatcctgg cggcgctgcc ggacgcggag gtcgacgact
     1201 acctcggcca ccacccgctg gacgcggtca ccccggccac catcacctcc accgccaagc
     1261 tgcgggccga cctggcccgg atccggcgtc aggggtacgc ggtgagcatg ggcgagcggc
     1321 agaacggcgc gggaagtgtg gccgcggcgg tgcgctacgc gaccgggcag gtgttcggct
     1381 cgatctcgct gtgcgggccg cagaaccggt tcaccccgga ggtgtgcgcc gcgcacgggg
     1441 cgctggtcgc cgcggcggcg gcggagatct ccgccgaact gggtttccgg ccgccggcgc
     1501 agcgtgtcgc cgggcggacg ggtcaggaac agaactgggg aggtggaaca ggtgagtgac
     1561 ggaccgctga cgggcctgcg ggtgcttgac gtctcgacga tcctcgccgg gccgctgtgc
     1621 tgtcagatcc tcggcgacta cggcgccgac gtgatcaaga tcgagcaccc gaccatgggt
     1681 gacagcatgc gcggccacgg caaggccaag gacggccatc ccctgtggtg gaaggagatc
     1741 tcccgcaaca agcggctggt cgggctgaac ctgtccgcgc cggagggcgc ggcgctgctg
     1801 ctgcggctgg ccgagcgggc cgacgtgctg gtggagaact tccggccggg cacgctggag
     1861 cgctggggtg tcggcccgga ggagctgcac cgggtcaacc ccggtctggt gatcgcccgg
     1921 atcaccggct tcgggcagac cggcccgtac gcctcccgcg ccgggttcgg cacgctggcc
     1981 gaggcgatga gcgggttcgc ccacctgacc ggcaccgcgg acggcccgcc cacgctgccc
     2041 gcgttcgggc tggccgacag catctgcggc atcgccacct cgtcggcggt gatgatggcg
     2101 ctgtggcacc gggagcgctc cggcggccgg ggccaggtcg tcgacatgag cctgctggag
     2161 ccgatcatga ccgctgtcgg tcccggcccc accgtctacg accagctcgg cgtggtggag
     2221 cagcggcagg gcaaccgctc gacgaacaac gcgccgcgca acacgtacca gaccaaggac
     2281 gggtcgtggg tggccatctc caccagcgcc caggccatcg ccgagcgggt gctgcggctg
     2341 gtgggccacc ccgaggtgat cgacgagccg tggttccgta ccggcgtcgg gcgggtggcg
     2401 cacgcggacc tgctcgacga gtacgtgggg tcgtggatcg ccgagcggac ccgcgacgag
     2461 gtggccgcgg cgttcgccga ggccggtgcc gctgtcgccc cggtctacag cgccaaggac
     2521 atcgtcgagg acccgcacgt ccgggccacc gagatgatca ccacggtcga cgatcccgac
     2581 ctcggcccga tgcggatgca caacgtcatg tggcggatgt cggagacgcc gggccggatc
     2641 cggttcaccg gacgctcccc cggcgccgac accgacgccc tgctcgtcga ggaactcggc
     2701 tgcgacccgg ccgagatcgc cgacctgaaa gcccgtggcg tcgtcgcctg acgacgccga
     2761 cagccgaaac gcgaggaacc ccgtgggcac cacagccaga accgccgacc gcctgctcga
     2821 cgccgtgcag gccggtgtca cgatctacga cctgggccgg cggctgaccg tcggcatgcc
     2881 gcagtcaccg aaccacccgg cgttcgggct caccctgccg cgccgccacg gcgacatggt
     2941 gcgcgccgac ggcggctccg ccgccaacga cctgctggtg atgggcacgc acgtcggcac
     3001 gcacgtcgac gcgctcgcgc acgtctccca ggacggccgg ctgcacggcg gcgccgacgc
     3061 cgccgacgcg caggtcggcg gccggttcga cgagctgggc gtgcacaccg tcgcgccgat
     3121 ggtccgccgg ggcgtgctgc tggacgtgcc cgccgcgctg ggcgtggaga cctgcgagcc
     3181 cggctacgag atcacccccg ccgacctgga cgccgcggtg tcccggcagg gcacgccggt
     3241 gggcccgggt gacgtcgtgc tcatccgcag cgggtggggc cggctgttcg accacgagga
     3301 ccgcggcgtg tacgtcggca aggactccgg cgtgccgggg gtcggcgcgg acggcgcgac
     3361 gtggctggcg cagcggcagg tgcacgccgc cggcgcggac accatcgcct tcgagtgcct
     3421 gccgccgggc aagggccaca gctcgctgcc ggcccaccgg atcctgctgg tcgagcacgg
     3481 cgtctacctg atcgagacga tggcgctgga ggagctggcc cgcgacgagg tgcacgagtt
     3541 cacattcgtc atggcgccgc tgccgctgta cggcgccacc ggctccccgg tgcgcccgct
     3601 ggcggtgatc agccgtggct gagccgaccc tgggccgcca cctggccacc ttcgccgccg
     3661 acaccgccgc cgagacgctg cccgacgagg tcgtcgcgag cgtccgggcc cgtgtcctgg
     3721 acgtgctcgg cctctgcgtg gcggcccggc cgctgccgac cagccaggcg gccctcgcct
     3781 acgtcgagga gcagggcggc cgtggccagg ccactgtcgt cggcctggac gagaaggcgc
     3841 cggccgcgct ggccgcgttc gccaacggcg tgctggcgca ctcgctcgac tacgacgaca
     3901 cgcacctgcc gtcggtgctg cacccgagcg cgtcggtggt gccggccgcg ctggccgccg
     3961 ccgaggcgtc cggggcgtcc gggcgggaga cggtcgcggc catcgccgtg ggcctggagg
     4021 tgtgcgtccg gctcggcatg gccggttacg acccggctgc cggcaactcc gtcttcttcg
     4081 agcacgggca gcacgccacc tcgatctgcg gcacgctcgg cggtgcggtg gcggcggccc
     4141 ggctgctgaa gctggacgcc gacggcgcgc tcgacgcgct cggcgtgtcc gcctcgatgg
     4201 ccgccggtct gatcgagtcc aaccgcaacg gcggcaccgt caagcggatc cactgcggct
     4261 gggcggcgca cgcggcggtg agcgccgcgc agctggcccg gcacggcgtg accggcccgc
     4321 cgacggtgct ggagggacgc ttcggcttct tccaggcgtt cctgcgcggc gagttcgacg
     4381 gcgacgagat cgtccgcggg ctcggcaccg actgggcggt accgggcatc ttcttcaagc
     4441 cgtacccggc gaaccacttc acccacgccg ccatcgacgc ggcgatcgcg ttgcgcgagc
     4501 gcgggttgcc gctggacgag atcgagtcga tcacgctcgg cgtgccgacg ccgacggtgc
     4561 gcaccatcgg ccagcccatc gagcgcaagc gggcgccgca gaccggctac gaggcgcagt
     4621 tcagcggccc gtacgcggtg gtcgccggcc tgatcggcgg cggcggtctc ggcgtggacc
     4681 tcgccgactt caccgacgcc ctggcgcacg acccgcagcg gcgggcgctg atggcgctgg
     4741 tcgacgtggt gggcgacgag cggtgcgacg cgatcttccc gcaccagttc ccggccgtgc
     4801 tgcgggtggt cacccgcgac gggcgggagt gggtgcagga ggtgctcgcc aaccggggcg
     4861 ggccgcagcg tccgctcagc gacgccgaac tggcggtcaa gttccgcacc aacgccgccg
     4921 ccctgccgga ggcgaccgcc gaccgcatca ccgaggaggt ccaccggcta gaccgggccc
     4981 ccgacgtcca cggcctgatg ggcctgatca accgccgctg aaccgagcac gaggagcaac
     5041 accatgagca cctacgacct gctgctgacg aacgtccgcg tggtccggca cgaccggccc
     5101 gaacccgagc tgatggacat cggcgtcacc gacggacgga tcagccgcgt cgccccgcag
     5161 atcgaccggg cggaggccgc ccaggtcgtc gacggcggcg gccggctcgc cttccccggc
     5221 gtggtggacg cgcaccagca ctggggcatc tacaacccgc tgagcgagga cgccgtctcg
     5281 gagagccgcg cctcggtgca gggcggcgtc accacggcgc tgaactacat gcgcaccggg
     5341 cagtactacc tcaaccgggg cggccggtac gccgacttct tccccgaggt gctgtccgcg
     5401 accgagggcc gctcctacat cgactacggc ttccacctgg cgccgatgtc gcgggagcac
     5461 atcggcgagg tgccgtccct ggtcgaggag cacggcgtca cctcgttcaa gatcttcatg
     5521 ttctacggca gccacggcct gcacggccgg tccaccgacc agaactcgtt cctgatgatc
     5581 ccggagggcg agcggtacga ctacgcccac ttcgagttcg tgatgcgggg cgtccaggcg
     5641 gcccgggagc gtttccccga gctggccgac gagatctcgc tgtcgctgca ctgcgagacc
     5701 gccgagatca tgagcgcgta caccaagcag gtcgagcagg acggcacgct gcgcgggctg
     5761 gaggcgtacc acgcctcgcg gccgccgcac tccgagggac tggccgtgtc gatcgcgtcg
     5821 tacctggcgc acgagaccgg cctgccgaag atcaacctgc tgcacctgac ctcggagaag
     5881 gccgtcgacg cggcgctgcg gatggcgcgg gcgttcccgc acatcgactt ccgccgcgag
     5941 gtgaccatcg gccacctggt cgccgacatc gacaccgcgc acggcctggg cggcaaggtc
     6001 aacccgccgc tgcgcccgcg cgccgacgtc gaggcgctct gggggtacgt cctggacggc
     6061 aagatcgact gggtggtcag cgaccacgcc tgctgcaagg acgaggtcaa gttcggtgag
     6121 ccgcgcgacg acatcttcgt cgccaagtcc ggcttcggcg gcgccgagta cctgctgccc
     6181 ggcctggtca ccgagggcaa ccggcgcggc ctgtcgtacc agcgggtggc ggagctgacc
     6241 tcgtggaacc cggctcagcg cttcggcctg cgcaacaagg gcgcgctgct gcaggggtac
     6301 gacgccgaca tctgcctggt cgacccggac tcgacctgga cggtgcgcgc cgaggactcc
     6361 gagtcgacgc aggagtacac gccgttcgag ggcttcgagc tgaccgcacg ggtcaccgac
     6421 accttcgtcc gcgggcagca cgtgctcgtt gacggcaagg tgaccggcga gccggccggc
     6481 cgctacctcg cccgcccgca gcggtagggg gaacaactga tggcggcggt ggcgcgcagt
     6541 tacctgtacg tgccgggcga ccgggcggac ctgctggaca aggcggccgg gcgcggcgcg
     6601 gacgcgctcg tgctcgacct ggaggacgcg gtcacgccgg cccgcaaggc gcacgcccgg
     6661 gagacggtcg ccgggtacct gggcgccgcc gcgccggccg gccccgagct gtgggtgcgg
     6721 atcaacagcg accaggtcga ggcggacgtc gaggtgctct cccccgccgc ggccggggtc
     6781 tgggtgccga aggccgagcc ggacctgctc gccgaggtcg acgcggcgct gacccgcgtg
     6841 cagcggcggc tcggcccgga cgccccggcg ttccgggtgg tggcgctgat cgagaccgcc
     6901 cggggcgtgc tcaccgcgcc gcaggtggcc gccgcagcgc gggtgctgcg gctcggcctc
     6961 ggcgaggcgg acctcgccgg tgagctgggg ttgcagcccg ggccggagcg ggcggagttc
     7021 gcgccgatcc gctcccaggt cgtggtcgcg tcggcagcgg ccggcatcac cccgccggtg
     7081 ggaccggtgg agacgacgct gcgcgacccg gagcggctgg agcagaccac ccgggcgctg
     7141 ctgcggcagg gcttccgggc acgcagcgcc atccaccccg ggcagatcgc gacggtcaac
     7201 gaggtgttca cccccaccga ggccgaggtg gcctcggcgc gggccgtact ggaggcgctg
     7261 gagcgggccg aacgcggcgg ctccggggtg gccaccgacg ccggcgggcg gctgctggac
     7321 cgggcggtgg tacgggccgc cgccgaggtg gtacgccgcg ccgaggcgtc cgccgggtga
     7381 cacgtgacgc cgggccgggg accgtcgacg ggtacgacgt ggcccggccc ggcgtgggtc
     7441 agggcgtgcc gagcgtggcg cgggcggcga ggatgtgcgc ccgcatcacc gagccggccc
     7501 aggcccggtc gcgcgcctcg aacgcgtcga tcagctcccg gtggtgcgac atgctgcgcg
     7561 ccatcgccgc ctcgtcgtac cggcggaacg tgcggttcac cagcggcgtc tgcaccaccg
     7621 ccccgagcag cgcgctcaac cggcggttcc gcccggcgcc caggatgatc tcgtggaact
     7681 gcgcgttgca gaccgcgatc cggtccgccc ggtcccgccg ctgaccggcc gcgtagccct
     7741 ccatctcggc gcacagctcg cgcagccggg cgatctcctc cggcgtgatc cgggtcgcgg
     7801 ccagctcggc gccgtacccc tccagcaggg cacgcagctc gaagatctcc tccaggtcct
     7861 gctcgcgcca ggccgggacg gtggcgcccc ggttggcctc ccagtccacc aggccctcgg
     7921 cgtgcagccg gcgcagcgcc tcccgtaccg gggtgcggct cacccccacc gcggcggcga
     7981 gatcctcctc ggagagcttc ttccccggct cgtacgcccc accgaggatg cgcgtcttga
     8041 tcgactcgta cgccgactgc gtggcccggc ccatgcgtcc ccctctgttc accgatggtg
     8101 aacctacatc gacgcggtgg aaccgccgtt gacggcgtac tccgagccgg tcacctgccg
     8161 ggaccggtcc ccggccagga agagcaccac ctcggcgacg tcctccggct cgttcatccg
     8221 gcccagcggc agccggcgca gctcgtgcac gacgtggtcg gcggcggcgg agacgtcgat
     8281 gccgagccgg agcgcgaccg actccaggta ggcgtccatg gtcgcggtcc gggtcgggcc
     8341 gggcgcgacg gtgttcaccc gtacgccccg ggagccgtac tccagggcca ggcccttggc
     8401 gaggctgagc agcgcggcct tgctgaccgc gtagtcgagc atgtgcggct tggggtgccg
     8461 cgccgcctcg gagccgatgg tgaccacgct gccgccgccc cgctcgacca tgagcggcac
     8521 gagcgcgcgg cacaggcgca cgcaggacat cacgttcacg tcccaggtgc gctgccaggc
     8581 ggcgtcgtcg atgtcggtga acgcgtcccg gtacggcgcg agcgccacgt tgttgacgag
     8641 cacgtccgcg ccgccgtacc ggctggtcac ctcccgcacg acggcggcga cgccggccgg
     8701 ggtgcccagg tcggcggtga ccgggacgcc cacgcacgcg gagacgtcca gatcggcgga
     8761 gaccacctcg gcaccctcgt cggccagccg gcgggccacg gcgagcccga tccccgatcc
     8821 ggcgccggtg acgacggcga ccctgcccct catccgcttc tcccctcggt accgccggcg
     8881 agcacctcgt cggtgtgctc gccgagcgtc ggtgcgagcc ggccggccgg caacggcgag
     8941 cccgacatga cgatcggcga ggcgacgctg cgcagccgcc cggccaccgg atgctcgacg
     9001 atcgacacca ggccggaccc ggcctcttcc tcctcgcgga ggatctcctc atagccggcc
     9061 agcggcgcgc acggcacgtc gatcgcggac agctccgtca gccactcggc cgtggtgcgc
     9121 ccgcgcagca cctcggccac gacccggtag agcccgtcgg cgttggcgat ccgcttgccg
     9181 acggtgtcgt agtcggggtg gcgcagcagg tcggcgcgcc cgaccagggt gaggaaccgt
     9241 tcccactgcc ggccggtgta gatcagcacg cacaggtgcc cgtcggcggt ggcgtacggg
     9301 cggcggttcg gcgcggcggt acgcgggtag agcggcggcc cgatgggcgg gtcgaacgtc
     9361 cagccgtcga gctgttcgag caggccgaag gcgaccatcg tgtcgtacat cggcacctcg
     9421 acgcgctgcc cctcgccggt ggcgtcgcgg tgccgcagcg cggcgagcac ggcggtggac
     9481 gcggtgagcc cggtgatctt gtcggcgagc ggcgtgacga cgtacccggg ctggtcctgg
     9541 ttgacgctct ggagccgggc gatgccggag gcgccctgga tcacgtcgtc gtaggcgggc
     9601 cggtcggcgt gccggctggt gccgcggaag cccgggatcg cgcagtagac gatcgccggg
     9661 tgcaacgcgc gtacgtcgtc gtaggtgagc gcgagccggg ccgcggcggc cgggcgcatg
     9721 ttgtgcacca gtacgtccac cgtcggcacc agccggtcga acgcggcccg gtcggcgggc
     9781 gccttgaggt ccagcaggac gctcttcttg ccccggttca tgttgaggaa caccgccgcc
     9841 atgccggggg tgcgggcggc gccgagctgg cgggcgatgt ccccgcccgg cggctccacc
     9901 ttgatcacct cggcgccgag gtcggccagc atcagcgtgc agtacgggcc ggagaacgtg
     9961 ctggtcaggt ccagcacccg gagtccggtc agcggcccgg tcacgggaag ccaccggccc
    10021 ggctcagcat gcccggcagc tcggcgccga acacctcgcc cagccacctg gcgttcccga
    10081 tcgccgcctc ctgcgacacc ccggtggctg tcccggagcg ttccaacgcg tacaccacgt
    10141 cctcggtggc cacgttgccg gtggcggccg gcgcgaacgg gcagccgccg atgccgccga
    10201 cgctggcgtc gatcgcccgc gccccggccc cgacggcggc caggacgttc gccaggccca
    10261 ggttgcgggt gttgtggaag tgcccgcgca ggctcgcccc gatgcgctcg cgtacggcgg
    10321 tgaacaggcg ctccacctgg gacggcacgg ccacgccgat ggtgtcggcg agcgccacct
    10381 cgtcgggcgc caccgatgcc aggtcgtcga cgacgcgcag cacgcgctcc ggcggcgtct
    10441 ccccctcgaa cgggcagccg aacgcggcac cgaccgtgac cgacgcgcgc agcccctgct
    10501 cgcgggcgcg gggcagcagc cgccgtacct gcgccaccgc ctcggcggtg gtcgtgccct
    10561 ggttgcgccg gcagaacgtg tcggtggcga cgaccacgaa gttgacctcg gtgacaccgg
    10621 cggcgacggc ccggtccagg ccgcggccgt tcatcaccag gccgatcgag gccaggcccg
    10681 gctcgtcgcg gaccagtgcc gccagcgcgt cggcgtcggc gagcttcggc accctcgccg
    10741 ggttgacgaa gctcgtcggc gggctgcgcc ggagcccgcg atgaccgggc cgttctccga
    10801 gcgccactgg cacgaggccg agacgtggcc gcgcgagcgg ctggccgcgt accagctcac
    10861 ccgcctgaag gcgcaactgt cctacgtgta cgccgccagc gacttctacc gcacccggtg
    10921 ggacgcgctc ggcttccacc cgggcgacgt ccgggaactg gccgacctgc gccgcctgcc
    10981 gctggtcggc aaggccgact acgtggccga cctggccgcc cacccgccgt ggggcagcgc
    11041 cgtcgccgcg ccggtcgcgg accgccgccg cgtgcacttc tcctccggca ccacctcgaa
    11101 cccgaccccg gtgctgtgga ccgcgcacga cctggaccgc tgggccgacc tgtacgcgcg
    11161 ggccgcgtac agccagggcg tccgggacac cgacgtgtac cagtgcctgt tcagctacgc
    11221 ctggttcgtc ggcgggctcg gcgcgacagc cggctaccag cgcatcggcg tgacgctgct
    11281 gcccgccggg tccggcgaca cccagcgaca gatcgacacg atcttccggt acggcaccac
    11341 agccgtcggc ggcacgccgt cgttcatgct gcacctggcc gagaccgcgg aacgcgccgg
    11401 cacaccgctg cgcgactcac cggtgcggcg gatccaggtc ggcggcgaac ccggcgccgg
    11461 ggtgccggcc acccgcgcgc acatcgagca gcgctggggc gccaagtgct tcgacgggta
    11521 cggcagcctg gagttccagc cgatcgcctg ggagtgcgag gaacaggccg gcggccacct
    11581 ggccgaggac ttcgcgtacg ccgaggtgct cgacccgtac acccacgagc cggtgcccga
    11641 cggcgcaccc ggcctgctgg tgctcaccca cctggacaag cgggcgagcc cgctggtgcg
    11701 gtgggccacc ggcgacgtgg tggtccgcga cagcaccgcc tgcccgtgcg ggcgcacgct
    11761 cgcccggctg ccgggcggcg tcgtcggccg ggccgacgac atgctcgtgg tacgcggggt
    11821 gaacctgttc ccgtccgccg tcgagcaggt cgtccgggcc acgcccggcg cctgcggcga
    11881 atacctcatc gtcctcgacg acgacgtcac cgacccggcg accggctacc tcaccggcat
    11941 caagctgcgc gtcgaggtga ccggcgacgg ccagcgggtg gcccgcgagc tggcgcacgc
    12001 cgtgcgcgcc gagctgacgg tgcgcgcggt ggtggagacc gtccccgagg gcacgctgcc
    12061 gcgcagcacc cacaagagca agcgcgtcgt acgcgccgac cggaaggttc cgtgatggac
    12121 aggcaagcgt tcctggtcgg cgccgtgcgt accccgcacg gccggtacgg cggcgcgctg
    12181 cgcgacgtgc gggtggtgcg tctgggcggg ctcgccggtg ccgaggcgct ggagcgggcc
    12241 ggggtgcccg ccgaggcggt ggacgagacg gtggtcgcca actgccgcca ggcgggcaac
    12301 ggcccgaacc cgggacggca gatctcgctg gcggcgggcg tgccggtgcc gacgcccgcg
    12361 cagaccatca acatggcctg cgcctccggc ctcaaggcgg tgcagctcgc gcaccggtcg
    12421 gtgcggtccg gcgaggccga cgtggcactg gcggtggccg cggagagcat gagcacgatg
    12481 ccgtacctgg cgccgtacac gctgcgctgg gacggcgtgc gccgcggcga cgtcctgctc
    12541 caggacggct ggcgcgacgg cggcaccgac ccgatctgcg gcatgagcat gggcgagacc
    12601 gcggagaagg tggcccgcga gttcggcgtg tcccgcgccg accaggacgc ctggtcggcg
    12661 cgcagccacc agcggctggc ccgggcctgg gagtccggcg cgatggcgct ggaggtcctg
    12721 ccgctggacg agctggaccg cgacgagacg gtacgccccg acaccacacc ggaacggctc
    12781 gcccggctgc gcccgtcgtt caccgacggc ggcacggtca ccgcgggcaa cgccagccag
    12841 atggccgacg gcgccgccgc ggtcgtggtg gccggcggcg aggcggtacg gcggtacggg
    12901 ctgaccccgc tgggccggat cgtcgggttc gcggccgtcg gcgtggaccc gacgatgatg
    12961 ggcgtcggac cggccgaggc cattccgctg gccctgcacc gggccgggct gaccgccgcc
    13021 gacgtggacc tgttcgagat caacgaggcg ttcggcgcgc agatcgtgca gaacgtgcgc
    13081 gcgctgggcc tggacgagga gcgggtgaac gtcaacggcg gcgggatcgc cctcggccac
    13141 ccgacgggac agagcggcgc ccggctgatc gtctcgctgc tgcacgaact ggcccgccgc
    13201 gacggccggt acggcgtggc gagcctgtgc gtcggcggcg gacagggcat cgccgccgtg
    13261 atcgagcggg tgacccggtg atcgccgtcg tggtcggcct cgggccgatg ggccggggca
    13321 tcgcgcaggt cctcgccgcg gcggggcaca ccgtccgggt cgtcgacgcc accgccgaac
    13381 tgggccgcgc cggcctggag cggatccgcg ccgacggtgc caccggcgac ctcggcgccg
    13441 ccgccgacgt cgagaccgcg ctcgccggcg cggacgtgct gatcgaggcg atcgtggagg
    13501 acatggccgc caagcgcgac ctgctcgccc gggtcgccgc cgccggcggg ccggacctgc
    13561 tcgtcgcctc gaacacctcg tcgctgagcg tcaacgagat gggccgcgcg ttcggcgccc
    13621 cggaacgcct gctcgggctg cacttcttca acccgcccac ccggatgcgc ctggtggagg
    13681 tgatcgtcgg cgcggccacg cacgacgcga cggtacggcg ggcgctggcg ctcgtggagt
    13741 cgctcggcaa gaccgctgtg gtgtgccggg actcgccgaa cttcatcgtc aaccgggtct
    13801 gccggccgct gtactacgag gcgcagctcc tcctcgcgca gggcgtcgag gcggcggtgg
    13861 tggacgcggt cgcccggggc gcgctcgggc acccgatggg tccgctgcaa ctgctcgact
    13921 tcaccgggct gcacacgcac ctggcctcgt cggagaccgc gctgcgcgag ttcggcgacc
    13981 cccgctaccg gcccatcccc caggtgcgtg gcctggtccg ggccggcctg accggcaagg
    14041 ccgccggccg cggcttctac gactacgcca ccgagccgcc gcgcgacgcc aacgcccggg
    14101 tggtccggcg gcccggggcg ccgaacggtc cggcggcccg cgtggtgagc ctcggcgcgc
    14161 cgaccccgca gcgggtggcg gagctggccc ggctggcggc ccggcagaac gtggtgctgg
    14221 acagctccga cgccggctgg gccgaggtgc tgcccgccga cgtcggctgg atccggctgc
    14281 accggcgcgc cgacgacgcc gtgttcgccg aggtggtcga ggacccggtc gcgggcgtcg
    14341 ccgtccccgg cttcgtcgac cggctgctgg atcacctcgg cgcgtcgtcg gtgcgggtgc
    14401 cggcgctgcc cggcctggtc ggcgaccggc tcgcccactg cctggtgaac gaggcggcca
    14461 ctgtggtcga ggagggcacc gccaccgccg acgacgtgga cgtggcgttg cgcctggcga
    14521 tgaaccatcc gcgcggcccg ttccagacgc tgcgggccgc cggggcgggg accgtgtacg
    14581 aggccctgcg gtcgatggcc gacgcgttcg gcgacccccg ctaccggccg gcgcaactgc
    14641 tgcggcggca ggcgatcggt gaggcgaggg ccgcccggtg acgcgggggg acgacaccgg
    14701 cgtggccgtg ctgcgcgcgg gtgtgctcac cgggcggcgc gcggtggtca ccggcgccgg
    14761 cagcggcatc ggccgggcgg tcgcgatacg cctggccgag ctgggcgccc acgtcaccgg
    14821 gctgggccgg cacgccgaca cgctcgccgc caccggcgag gcgatcaccg gcgaggcggc
    14881 caccgggggc ggccgctaca cgtacgcggt ctgcgacgtc cgcgaccacg accgcgccgc
    14941 cgccaccctc gccgaggcag gcgaggcgca cggcatcgac ctgctggtga acaacgccgg
    15001 cgggcagttc ttcgccccgg ccacgcggat ctctgcgggt ggctgggccg cagtcgtcga
    15061 cctgaacctc acaagcgtct tccacctcac caccgccgcg tacccgtacc tgcggcgcac
    15121 ccgcggcgcg gtggtgaaca tgtcgctgtc aggggtggaa cgcggcgggc agggcatggc
    15181 gcacgccgtc gcggcccgcg ccggcgtgct cgggctgacc cgcacgctgg ccctggagtg
    15241 ggccgccgac ggtatccggc tcaactgcct cggaccgggc acggtgctca ccgccgcgct
    15301 cgacgccgag gccgaccggc acgtgcggga caacctggtg gaccgggcca cgccgctgcg
    15361 ccgcccgacc cgcgccgagg aggtcgccga gctggtggcg ttcctggccg gcccggccgc
    15421 cgccatgatg accggccagc tcatccagct cgacggcggc gcacacctgg gaccggggct
    15481 gcacatgctg gcggaggcgt accggtgagc cgcgccctcg ccgacgtcgt ggccgagcac
    15541 gtacgccccg gacgacgggt ctacctgggc aacttcggcg cgcaactgtt cgccgtgggc
    15601 cacgagatga tccggcagcg gatccgggac gtggacgtgg tgatcgcctc cggcgggctg
    15661 ctgatggacc agttgctcgg cgccggggtg ctgcggtcgg ccacgtacgg ccactgctgg
    15721 agcccggtcg gcccggcgcc cgcctggaac ttccggcgtg ccgcgcagga cggcgacacc
    15781 cgcgtcacgc tgcacgaact gagcctcggg ctgctcaccg cagcgctcac cgcgggcgcc
    15841 tggcgggtgc cgttcatgcc ggtgccggac ctgcccggca ccggctacct ggacgaggac
    15901 tggagccggg ggcggctgtc ctcggtcgac tcggcgttcg ggccggcccg ggtggtccgc
    15961 gccgagcggc ccgacgtggc gttcgtccac gtggacctgg ccgacgccga cggcaacggg
    16021 atgatccgcg gcccgctcgg tgaggtgctc gtggccgccc aggcggcccg gcgcaccgtg
    16081 ctcgtcgccg agcaggtcac cgacgccgag acggtacgcg ccgccgggat cagcattccc
    16141 gggctgctcg tcgacgcggt ggtcgagtcc cccggcgcgg tgcaccccga cggcgcggtc
    16201 ggccggtacc cgcgtgacgt cgaggcgtac cagcggtatg cccgccgctc ggccaccgcc
    16261 gacggtttcc ggcggtggct ggccgaggag gtgctgtgac cacagcggac ttcctggtcc
    16321 gggcggcgcg ggagttccgg cgcggcggct gggtgttcac cggcttccac tggccggtgc
    16381 tcgccggcca ctgcgcgtac gcgctgcccg gcgaaccgtt cagccaggtc ttcgaggccg
    16441 gcgccagcgc gcaccggccc ggcgcggacg tgccgaccag caccaccgac tacccggcgt
    16501 acgccggcgg gttcggctgg ctgggcggca ccgccgacgt gctcctggcg atgggccacc
    16561 ggttcgaccg ggtggtgctc gacgccggca acgtggacct gcgcggccgg atcaactcgt
    16621 cgtacctggg cccccgggag cggcccacgg tgcggctgcc cggcggcggg ggcgccgccg
    16681 acatcgcggc ggcggcacgg gaactggtgc tgctgcacgg cgcacgggat ccacgccgga
    16741 tcgtgtgcgc ggtcgagcac gtgaccgccg cgcccgcccc ggacgcgctg gtgcggctgc
    16801 acacccggtg gggcgtggtg cggctcggcg ccgatccgcg gctggaggag gtcaccgcgg
    16861 acggcgaggt gctgcgtgcc cacctggccg cgctcggcgt acccgtcgac ggcgcggcgc
    16921 cccggccgcc ggtcaccgcg gccgaacgcg ccgcggccgt cggcgtgctg cggcgcgccg
    16981 ccgtacgggg ctactcagtg gcgaagggaa cggacagagg atgactgacg acgatctcga
    17041 tgagctgcgc cggcaggtac ggaagctggt cggtgagtgg cgtgacggcg accggttccg
    17101 gccggtgtgc gacgcgtggc tgcgctcgta cgacacggag ttcagccgcg cgctggcgga
    17161 ccggggctgg atcggcctga cctggccgcg cgagtacggc gggcaggccc gctcgaaccg
    17221 ggcccggctg gtggtcaccg aggaactgtt gcgcgccggg gcgccggtgg ccgcgcactg
    17281 gatcgcggac cggcagatcg gcccggccgt cctgcggtac ggctcccccg cgctgcgcga
    17341 gcggtacctg ccggcgatcg ccgccggtgc ggtgacgttc tgcctcggca tgagcgagac
    17401 cgagtccggc agcgacctcg cctcggtgcg caccaccgct cgcccggacg gcgacggctg
    17461 gcggctcacc ggcggcaaga tctggaccag tcacgcccac cggtccacgc acgcgtacgt
    17521 gctgtgccgc accggcaccg gcggcgaccg gcacgagggc ctgaccgagc tgatcgtgga
    17581 catgtccgcg cccggcgtca ccgtccggcc gatcgtcgac ctgcgcggcg agcaccactt
    17641 caacgaggtc gtcttcgacg acgtgcgggt gcccggcgac cacgtgctgg gcaccgccgg
    17701 caacggctgg acgcaggtca ccgagcagtt gtccttcgag cgcggcggga tggagcgggt
    17761 gctcagcacg tacccgctgc tggccgccac cgtcgacgcg tgcgccgcgc ggcgggacgc
    17821 ggacgccgcg ctgggcgagg cgctggcccg gctggccggg ctgcgcggcc tggcctggcg
    17881 catcgccggt gagctggacg ccgggcaggc cccggtgcac gccgcggcgg tgctgaagga
    17941 cctgggcacc gagttcgagg ccgacgtcaa cgagatcgcc cgtaccgtgc tcgacgtcga
    18001 gcccgacccc gacggcgacg gaccggccgg gctgctcgcc caggggctgc tggccgcgcc
    18061 gggtttctcg atccgcggcg gcaccaccga ggtgctgcgc accatcatcg ccaagggcgc
    18121 cgcccgcgcg ccccggcgcg gcggcgacga gctgcgggag ctgaccgacg acgtgctcgg
    18181 cggtcacggc ggcgacccgg acggcctgcc cacgctctgg tccacactgc acgggctggg
    18241 ctggaccggg gtgtcggtgc cggaggacgc gggcggctcg ggcggcacgc tcgccgacct
    18301 ggccgcgctc gtgcgcgggc tgggtcgcca cggtgtctcc ctgccgctgg ccgggaccgt
    18361 gctggccgcc cggcagctcg ccgccgccgg tcgcggcctg cccgagggcg tcgccaccgt
    18421 ggtcgccggc gacgggctcg cggtggccgg cgggcggctg cgcggcacgg ctgcccgcgt
    18481 gccgtgggcc gccgccgcgc ggacactgct ggtgtacgcg ggcgacgagg cgttcgtggt
    18541 gcccgccgac caccccggcg tgcgggtcac gcccggccgc aacctggccg ccgagccgcg
    18601 cgacgacgtc gtgttcgacg tgccggtcac cggcgacatg cggctcaccg gcgtcgcgcc
    18661 cgccggggcg gtacgcgccg aggcggcgtt gctgaccgcc gccgcgctca ccggcgcgct
    18721 ggagacggct gtggagcaca cccggcagca cgtgacgacg cgggagcagt tcggccggcc
    18781 gctgctggcg ttccaggcgg tcgggcagac cctggcccgg atgaccgcgc acacgctgct
    18841 cgccggcacc gcgctcgacg ccgcgctggc cgggccggac ccgctgcggg tcgccgccgc
    18901 gcgggtgctc accggccggg ccgcgacgat cgtggcgcgc ggcgcgcacc agctgcacgg
    18961 ggcgatgggc gtcacccgtg agcacccgct gcacctgtcc acccgcaggc tctggtcctg
    19021 gcgggacgag aacggcaccc agcagttctg ggccgccacg ctcggcgcgg cgctggtgcc
    19081 gcgcggcagc gcgggcgtct ggtcctggct gaccgatcag gaggctgagt catgagcaaa
    19141 gtggaactgc acaacgcgga cgggcgctgg acgctcacgc tgaacgaccc ggaccggcgc
    19201 aacgccatcg acgcggagat gcgcgacgcg ctcggcgacg cgatcgccga ggtggccgcc
    19261 gaccggcacg cccgcacgct cgtggtcacc ggcgcgggca cggcgttctg cgccggcgcc
    19321 gacctgcccg ccatgttcgg cgaaccaggc cgcggcgtcg cggagatccg cgccgacctg
    19381 caccgcgtct acgacagctt cctgcgggta cgggcgctgc cgatcccgac gatcgccgcg
    19441 gtgcagggac cggcggtggg tgccgggctg aacctggcgc tcgcgtgcga cacccggatc
    19501 gtcgggccga aggcgaagct gatcgcctcg ttcacgaagc tcggcctgca ccccggcgga
    19561 ggctgcacct ggttcctcac ccgggcgctc ggcccggaac gcgccctgca actgctgctc
    19621 gacggcggga gcgtggacgg ccccgaggcg gtacgcgtcg ggctcgccgc gacgctcgcc
    19681 gacgacccgc tggcggccgc gcacgagcgc gccgaacggt gggcggcgct ggacccggcg
    19741 ctggcccggg acatcaagac gtcggtgcgc accgcggaga cggccggttt cgccgccgcg
    19801 ctggagttcg agtcgtgggc ccaggcgtcc tcggcgaccg ggccggcgat ccaggaggcg
    19861 gtggccgcgt tccgcaggtg acccgtccgc cgcgggaccg ggcggggcgc cgctgtgcgc
    19921 cccgcccggc ggcgtcacgc cgccgctccg gtcagaccac ggcgggctgt gcctcggtgg
    19981 ccatgacgag cgcgccgagc agcgcggcgt cctgcgcgaa gtccgacagc acgatctccg
    20041 gcgggtacgg cagcgtgtgg gtgagccgct cggtcagcag ctcccgcacc aggtcgttgc
    20101 cggcgacgct gccgaccagc acgatccgct gcgggtcgag cagcaggcag cacgtgacca
    20161 gctggcgggc cagttcgtcg acgcgcaggc ggagctgctc ccgtaccggg ccgggctgct
    20221 ccgccgccgc gcacaggccg gccgatcggc cgtccacgcc gaggcgctgc gccagctcgt
    20281 ccagggcccg gccggagaac gtcgcctcca gcatcggttc caggcggggc ggccagctga
    20341 ggtcggtcag tccgtaggcg atctcgccgg ccgcgccgtg gcggcccggc agcacctcgc
    20401 cgttgaccgt caccgcggcg gccaccccgg tcccgagccc gacgacgagc cccggatcgg
    20461 cgtcgcgcag ggccccgagc cgcagctcgg cgtaggcggc ggccttcagg tcgttcgtca
    20521 cccgcacgtg cgcgaggttc aggtgggcgc ggaccgcctc ggccagccgc aactgttccc
    20581 agccggggac gttcggcgcc agttcgatgc cgtcgtcgtg gacgacgccg ggcgaggcga
    20641 tgccggccgc gacgatcgtg ccgccggtct gctcggcgag ttcgcacgcc cggtccagcg
    20701 cccgggtgag ggcctgctgc gcgccccgct cggcgatcgt gggcaggcgc tcggagacga
    20761 gcagccggcc gtcggtgtcg cccacgccga tcgccatctt ggtgccgccg aagtcgatgc
    20821 cgagcaggcg cggatttgcc ggtcgttcca tggtgatgtc agatcgccct tcgggccgtc
    20881 ggtccagatc acgtggtcgc cgcgacacga cgtccgcgac cacggccagc tgcggctgcc
    20941 gccccgtcac aggcctaccc tcgccgcgac cgcctcggcg agagccgcgt cggcacgggt
    21001 cagccgctcg cgcaacgcct gcgcccgctc ctgcaccgcg tcgagcattg tagacagtcg
    21061 tccgacctgg tcccggacgg ccgcctcgcc gggaccgtcg gcctgggcgc ggcgcagcac
    21121 gagttccggg cggaccgcgg cggccagcaa atcccgtacc gcggcgtcgc cgagcgtcag
    21181 accgaggtcg gcggcggtgg accggaccag atcctcggtc caggtcgccg gggcgccgcc
    21241 gcggaccagc cggccgagca gcgagtgggc gccgcggaac ggcacgccgt ggcgggccag
    21301 cgcgtcggct gccgcggtgg tggtggcgcc ggaggcgacg atctcctcgc cggacggcgg
    21361 gcgctgcggg tccagcttgt cgatcaggcc accgagcagc gagaagaacc ggtacgcccg
    21421 gtcgtccccc tcccagagcc gggactgcac gtcggtggtg gcgttgttcg agtcctccca
    21481 ccaggcggca cccacgttgt tgagcacgct cgccgcgtcg gcagcggcgg cgccggccat
    21541 cgagacgagg tgttccagca ccaccgggtt gcgcttctgc ggcatgatgc tgctgccctg
    21601 ggtgaactcg ccgggcgtga ccacccagcc ccagctcagc cagtccatca gggtgcgggc
    21661 gagccgggcg ccggtggcga gcgcctgcgc gttgagcgtg gcgacccgga ccaggtggtc
    21721 ggcgccggcc accgcctcgt acgagttgac gatgagctgg tcgaagccga gcaggtcggc
    21781 cagccggcgg ggcgagatgt ccaggtcggt gccggcgaag gcgcaggagc ccagcggcga
    21841 gcggttcatc tcgtccagca ggccggcgta cgcggcggcc tcgccggcga gcgcctcggc
    21901 gtagccggcg aagacgtgcc cgatgctggt cggctgggcc gggcggcggt gcgtgtagcc
    21961 ggtgatcacc acgtcggcgt gccggtccgc gcggtccagc acggtacggc cggtcgccag
    22021 cagcgcgtcg agcacctgga gcagctggtc gcgcagcacc atccggaaga cgccggcgtc
    22081 gaggtcgttg cggctgcgcg cgagctgcac gctca
//
