LOCUS       NZ_CP084582            24740 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Micromonospora aurantiaca strain G9 chromosome, complete genome.
ACCESSION   NZ_CP084582
VERSION     NZ_CP084582.1
KEYWORDS    RefSeq.
SOURCE      Micromonospora aurantiaca
  ORGANISM  Micromonospora aurantiaca
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Micromonospora.
REFERENCE   1  (bases 1 to 7149079)
  AUTHORS   Schneider,B., Pfeiffer,F., Dyall-Smith,M. and Kunte,H.J.
  TITLE     Genome Sequence of Micromonospora aurantiaca Strain G9, a Member of
            a Bacterial Consortium Capable of Polyethylene Degradation
  JOURNAL   Microbiol Resour Announc 11 (5), e0114821 (2022)
   PUBMED   35389268
REFERENCE   2  (bases 1 to 7149079)
  AUTHORS   Schneider,B., Dyall-Smith,M., Pfeiffer,F. and Kunte,H.-J.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-OCT-2021) 4.1, BAM Bundesanstalt fuer
            Materialforschung und -pruefung, 12205 Berlin, Unter den Eichen 87,
            Berlin, Berlin 12205, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. SEPT-2021
            Assembly Name                     :: BAM_Maura_1.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 427.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 09:59:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,512
            CDSs (total)                      :: 6,447
            Genes (coding)                    :: 6,372
            CDSs (with protein)               :: 6,372
            Genes (RNA)                       :: 65
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 53
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 75
            CDSs (without protein)            :: 75
            Pseudo Genes (ambiguous residues) :: 0 of 75
            Pseudo Genes (frameshifted)       :: 25 of 75
            Pseudo Genes (incomplete)         :: 59 of 75
            Pseudo Genes (internal stop)      :: 6 of 75
            Pseudo Genes (multiple problems)  :: 15 of 75
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:21:19
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 652851
            Orig. end                         :: 677591
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP084582.1.
            Bacteria and source DNA available from BAM, FB 4.1, Hans Joerg
            Kunte, Unter den Eichen 87, 12205 Berlin, Germany.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24740
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="3"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24740
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24740
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14740](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14740
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(102..117)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.52"
                     /tool="antismash"
     gene            1075..4518
                     /locus_tag="LF814_RS32695"
     CDS             1075..4518
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020520250.1"
                     /locus_tag="LF814_RS32695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="M28 family peptidase"
                     /protein_id="WP_318528071.1"
                     /transl_table=11
                     /translation="MATQSTAATPPPTPTVAQSPLSLAISAADRAADGGHDALAKGPFE
                     QYDRRMVIPWVDGLFSIAYERTYRGLPVVGGDAAVLADGRGAIRAISAATKTKINVSVV
                     PTVAADRAEQTAKGLLTKVDQVESRTLVVHVKDSTARLAWEVVVAGRTASAPSHLHVFV
                     DARNGQVLAKQEDAAAGSGTGKWNGPSPLSITTSQSGSTYYLRDTTRTGLNCQDYSTST
                     VFSGADDSWGNGVGTSKETGCVDALYSAQKEWDMLSAWLGRNGHNGNGGSWPIKVGLNE
                     QNAYWDGSTITIGKNSAGNWISSMDVVGHEFGHGMDQNTPGGTSSEAGLGEATGDIFGA
                     LTEAYANQSSAYDEPDYLVGEEIDLVGDGPIRNMYNPSLVGGHPNCYSSSIPNTEVHAA
                     AGPLNHWFYLLAEGSAPGGGKPNSPICSGGPSSVTGVGIQSAGKIFYGGMLLKTSGMTH
                     KKYRTATLTAAKNLDSSCVLFNRTKDAWNAVAVPAQTGDPTCTGSSTDFSVSVSPTSGS
                     VNAGSSVTATVNTATVSGSAQTVSLTSSGAPSGVTVSFSPTSVTSGNSSTMTVATTSSA
                     AAGTYTITVTGTGSITHTAQYTLTVNGGTPGGTAPDIDVANVQAHLTQLSTIATNNGGT
                     RRSTGQGYLQSVAYVKGKLQAAGFTVTEQPCTSGCTSGAGPNLIAEWPGGNASNVYMFG
                     AHLDGVSVGPGINDNGSGSAALLEVALALAAQNPTMLNKVRFGWWTDEEQGLNGSKFYV
                     NSLTSTQRTAIKAYYNFDMIASKNGGYFINNITSTASQPMKAYWDSLSLQPEENVEGQG
                     RSDDYSFQNAGIPTSGYAMGASATKTSAQASKWGGTAGQSYDSCYHSSCDTLSNIDATA
                     LNRAADGIAYTLWNRAVGTSTPTNDFSISASPSSGTVNAGSSTTTTVGTATTSGSAQTV
                     TLTASGAPTGVTVSFSPSSVTSGSSSTATIAVGSSVAGGTYTITITGTGSVSHSTTYTL
                     TVTGGPGGCTAAQLILNGGFESGTSPWTGSTGAIGTSIGQVPRSGTRYAWLGGYGYTAT
                     EAISQTVTIPSGCTSAVLTYWLHIDTSEYGALAYDVFTIKANGTTVASLSNMNAATGYT
                     QRTVNLGAYAGQTVTLTFTGTEDAYLQTSFVLDDVTLQIG"
     gene            complement(4941..5390)
                     /locus_tag="LF814_RS03350"
                     /old_locus_tag="LF814_03355"
     CDS             complement(4941..5390)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LF814_RS03350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LF814_03355"
                     /product="hypothetical protein"
                     /protein_id="WP_124778772.1"
                     /transl_table=11
                     /translation="MTATTTLVVQDPVDAYELFAHARTVLRLPLDGRWHLVDHGRVHML
                     QTLPGQGAPALASVHLPVDGSRHPGEPHAGIPGGYALLAFTTDGGDTNRTQRRHRDLAG
                     QASAWLTHRRLRWTWSHADGPFTTNHADLATRGQIVDLFGGLRGP"
     gene            complement(5396..5743)
                     /locus_tag="LF814_RS03355"
                     /old_locus_tag="LF814_03360"
     CDS             complement(5396..5743)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018833936.1"
                     /locus_tag="LF814_RS03355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_03360"
                     /product="hypothetical protein"
                     /protein_id="WP_091113588.1"
                     /transl_table=11
                     /translation="MPIKGARRQPCRKGFRRFSSPTGAGRGFRVPGFRGGDFGFVAYAD
                     TDTAQDVLVRVVGGDTDPGAQTAPLARARELWWLSRAVRAKYTAISRAVPLLLAGYAGA
                     ATTAALAIWAR"
     gene            6092..7561
                     /locus_tag="LF814_RS03360"
                     /old_locus_tag="LF814_03365"
     CDS             6092..7561
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.4"
                     /locus_tag="LF814_RS03360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_03365"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_151010815.1"
                     /transl_table=11
                     /translation="MIARIFNRPGTISAVSSPPCVGRGGLIQEALARQVHTTRSTLGMV
                     ERGRQVVDRIFWLQCDTLLDAQGELLAAYDAYRHLQSRFQAQQAEAAQRARWGAVPEAV
                     MAAGEATGERYGEVGDNRRPPDRFHGERPEAGRTTRTGQVSVVNAVAGRGEEADHDARS
                     RLLAELRRHLLAPAAPKQPVEPLTLSEVRQRVAHLHSLYQRGNYAEAVRALPDTFEQAN
                     LLTRTCTGTQRALAVGSLAAANLAAAKLTVKLGDPSLAWVAADRAARVAAEQAEDVALV
                     AAAAFSVGTALLAMPDRVGDAEEVVLAALDGVTDTRDSASTGPRVLSAHGALTLLAALI
                     AARQAQPAAVERHLDDANALARRLGADRNDLWTGFGPTNVMIHRISIAARTDQPQLAIH
                     LGEQLDTSSLPAALVSRRARVHLDLAAAYACSPGNDPAAVLHLLEAERIAPQTVHVHGR
                     TRHLIGDLLTRERRAVTPGLRALAERAGIAA"
     gene            7558..8100
                     /locus_tag="LF814_RS03365"
                     /old_locus_tag="LF814_03370"
     CDS             7558..8100
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Flavoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018586217.1"
                     /locus_tag="LF814_RS03365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_03370"
                     /product="flavoprotein"
                     /protein_id="WP_046569670.1"
                     /sec_met_domain="Flavoprotein (E-value: 1.9e-13, bitscore:
                     49.0, seeds: 143, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSGSANARLLYLVVCAAPPARRIVELVEAVRRDGWDVYVIATET
                     AHTWLPNDRLAAVTGRPVSYRQRHPDEPSVLPRADAVAVVPATFNTINKWATGINDSLA
                     LGILNEALGAGMPIIVSPYVKPTLARHPAFDAHLRLLADHGVRLTATEALRPAHDDQPF
                     RWNVILDELHRLSARLS"
     gene            8533..9771
                     /gene="fxlM"
                     /locus_tag="LF814_RS03370"
                     /old_locus_tag="LF814_03375"
     CDS             8533..9771
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018725297.1"
                     /locus_tag="LF814_RS03370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_03375"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_043330488.1"
                     /sec_met_domain="PCMT (E-value: 2.1e-26, bitscore: 91.6,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVDTMSSDDLRDAMVDQLVADHAAKGLTMRPEVEAALRVVPREL
                     YTPGVPMEEAYRSDTAVVTKRLGDETVSSVSAPWLIAEMLGQAADALTGGLHGRHVLEI
                     GSGGYNASLLRELVGPSGSVTTVDIDPEVTERAVACLAVAGYGDVSVVCADAEQPIDLG
                     RCYDLIIVTAGAWDIPAAWIAQLAEDGVLVVPLRTFGMTRSWALRRVGDRLVSHSQRLC
                     GFVAMRGTGAHEMRYVDIAAGVHLRLDEGQQVDPESVGGLLSQPQEQAWAGVGLPPRSV
                     LADLDLWLAARLADEVDQFVVLSAQQEAVDAGIVAPAWRFGTPAALHEGTFSYRSTLRW
                     TDDTFDLGACAHGPDAAAAAGRMAGHMRAWVDAGEPSPVLHVLPAGTPDGALPAGTVLD
                     KRHSRLVLTFTSA"
     gene            9795..9932
                     /locus_tag="LF814_RS03375"
                     /old_locus_tag="LF814_03380"
     CDS             9795..9932
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018588904.1"
                     /locus_tag="LF814_RS03375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_03380"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_082159628.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 2.2e-14, bitscore:
                     51.6, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELEEFDLDITLVDAGPAASGYATSTDDGCGSGNTGSNACSGGSK
                     "
     misc_feature    complement(9995..10006)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     gene            10001..12742
                     /locus_tag="LF814_RS03380"
                     /old_locus_tag="LF814_03385"
     CDS             10001..12742
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018831025.1"
                     /locus_tag="LF814_RS03380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_03385"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_064448554.1"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 6e-13,
                     bitscore: 47.9, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.1e-94, bitscore:
                     315.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.6e-14, bitscore:
                     52.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFPTAGAALIRVAAYPSGLTLPAWPDLTTDQPEQWRQWLAAVWAL
                     PGFATAVAAATPQLAEQITRTVASAPTTDRRFGRMVDSTVRYLLRWTTRATPFGTFAGV
                     APVEFGARASVRWGEAHQVVTRPDGTFVAEHTGRAEQDLAALRDVAVVTNSVGYQRGEV
                     WVLPCLRGDGDRRWDIEIRLTRPVRAAIRAARSPVMFGDLAARVAGPLPAATGAAERML
                     ASLVQAGVLLSALRPATTVTDPASHLARHVPMPDPGDRVAVDLRVDASVTLPPAVLHEA
                     ARAASTLVAVAAPLPGWAEYHGAFIQRWGPGAAVPLRDVLNVLGFPAGYRGSTRRVPAV
                     FTARDRLLAQLAQQSALNDCTEVILDDELTGRLRGDDDRPPIPHTELRFTLAAATPQDL
                     DRGAFTLTVVSGARHAGVAAGRFLHLLSPAELASFQHVYRNLPTALPGADTVQLSGPPL
                     DARLAAVARTPAVLPVLPVGDFHPDPPWTLADLAVTGDGQRLWLVSRTSGRPVEPLLLN
                     SVLLPDLQQPLMRFLTEIWTAWTAPCSRFDWGHARSLPFLPRLRRGRSIVHPARWTIDR
                     TALPARTLAWSHWRDAWQRYREQHRLPDEVLVGADDVQVRLDLNDNTHLAVLRRHVDRH
                     ARTTLTEAPGPAGWIGGRPAELLLTLAHTRPATHPSRPARAVTAQQHRPGQSPWLEARL
                     YGRADDILTDLAHRTGNLPAAGWWFLRYPDPEPHLRLRIPLQDTTFAATAACLAEWAQQ
                     LEHKRVLHDYSLRTYRPETRHGTGPTLTAAEAVFAADSRATLQRLTGDRQASTAATMIA
                     IADAFTGDGPRWLAEHVPHHRGPRLEPVQLDLARTPYRDDDLDKALATYRTLAHADNLD
                     LDQVLTDILHLHHARMIGVDPASERHCLRLARAVARTRQATP"
     aSDomain        10454..10714
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_LF814_RS03380_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.60E-15"
                     /identifier="RREFam001.1"
                     /label="LF814_RS03380"
                     /locus_tag="LF814_RS03380"
                     /protein_end="238"
                     /protein_start="151"
                     /score="47.9"
                     /tool="antismash"
                     /translation="VTNSVGYQRGEVWVLPCLRGDGDRRWDIEIRLTRPVRAAIRAARS
                     PVMFGDLAARVAGPLPAATGAAERMLASLVQAGVLLSALRPA"
     misc_feature    10949..10951
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            12739..13815
                     /locus_tag="LF814_RS03385"
                     /old_locus_tag="LF814_03390"
     CDS             12739..13815
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018831026.1"
                     /locus_tag="LF814_RS03385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_03390"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_043325490.1"
                     /sec_met_domain="LANC_like (E-value: 1.2e-36, bitscore:
                     124.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAAQSLAEGAAGVALLHLETGNRPAAHAALRAATANGVSIAAGA
                     SLFYGAPALAFVLATPNQPGLTRARSIAATGTATVTRRRLHAAHRRIDSHQRPHYAEYD
                     LIRGLTGLGVALHRLGDHDLLRQVLTYLVRLTEPVNDLPGWWCANGPDRHQPPPPGGHA
                     NHGIAHGITGPLALLALTHRAGITVDGHTEAILRICRWLDTWQQHTADTIWWPQTLTLD
                     DLHHGAPAQQHPLRPSWCYGTPGIARAQQLAALALHDTARQLLAETAFTTCVNDPAQIR
                     RLTDRSLCHGTAGLLATGRRIAADALTPTPLAPLTRLHLHATPAADEPTGLLDGTAGHA
                     LAAASTTSTSWDACLLLS"
     gene            13829..14740
                     /locus_tag="LF814_RS03390"
                     /old_locus_tag="LF814_03395"
     CDS             13829..14740
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018817829.1"
                     /locus_tag="LF814_RS03390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_03395"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_069089169.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.4e-23, bitscore:
                     82.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKETPWQQVNITYPGQSRHEREQHAIPHLHRVLPAAETAGLITSW
                     WFIRKGPWRIRYLPTTPDTDPGPVHDLLTGTRAWTSDIYEPEIHAFGGPDAMDTAHTLF
                     HHDSRHLLTYLHHQPADRRERSLILCTALMRATGLDLNEQGDVWARVARHRLEHRTWPP
                     AADPATWEAFTGKVRHLQLGTTRTTSDWQTAFENAGTALRHLRDTGKLTRGLRAVIAEH
                     VIFHWNRIGIPATTQAVLAQAAAEAIFGRAPVPPGEQWPRPVEPVPPSAVPPTEVDAPS
                     RAALASSRHSRLLTEGASAQWS"
     gene            complement(16453..17334)
                     /locus_tag="LF814_RS03395"
                     /old_locus_tag="LF814_03400"
     CDS             complement(16453..17334)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1276: PfkB domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012515.4"
                     /locus_tag="LF814_RS03395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_03400"
                     /product="PfkB family carbohydrate kinase"
                     /protein_id="WP_151010813.1"
                     /transl_table=11
                     /translation="MSHQLPDQVRTPHVAFVGRANIDITVRIPQRPVAGRTTFASSPAT
                     TTPGGKSLNQALAARQAGVRASLISNVGDDEWGASLSRALTNAAIDMSFLQVVPSAPTG
                     TAIIEITPDGENYIVLAHSTETELASEHVRNALQQLRAPIVVTQLDLQPDAVDAVFRHH
                     HAETLIGNLVPHPSLGLTALAPLDLFVSNEAEAAAILGRHHANPSIAAQELRKLGPRAV
                     VVTAGARGAAYSDADHTALVPASHVKAINTSGAGDAFLGTLAARLAHNVPLPHAVAKGV
                     AAATTFVQVDRR"
     gene            complement(17331..18836)
                     /locus_tag="LF814_RS03400"
                     /old_locus_tag="LF814_03405"
     CDS             complement(17331..18836)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.4"
                     /locus_tag="LF814_RS03400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_03405"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_225319461.1"
                     /transl_table=11
                     /translation="MIDPQRVDDAKRALGARLAAWRNVRGLTQLALARRVPVSRTTIAG
                     VERGQQCPDRIFWQRCEAALAAGGELLADYDDYRRLKQQLDQEKVEAAQRMRWGEVEDR
                     SLPAGTHGVPVTDPARESLRDLAATDLTAGGPNGLTAPLARVAGAAVAGETDFHDGDAV
                     TLAVMSDGQAMSLRVSRRALLELAAGLTAVPVVTTAGVSHPRSVDPAVVDHFAELRALL
                     VQADDRLGGLTILSTVEQQIALIAALRRQTRGQLRNRLLSTEARWSEFAGWLSDDLGDR
                     AAGDRWLDRAGSMAQEADDQEFWAYVLTRKAQRMVGTGDEDCVVGLARAASRLPDTPPL
                     LHAFAAIQQAHGSAIAQDASAFQAAVERAHTLVATARPPSGGSSALGSFCTRPYLAAQE
                     GEGWLRLNQPRRAIDSFTNAVNTWPDRYRRERGVYLSRTAHAYLAASEPGQAATVAAEA
                     LTTATTTGSVRVRRNVTTLARRLEPFSSQPEVRQLLDQLATSG"
     tRNA            19231..19306
                     /anticodon=(pos:672115..672117,aa:Arg,seq:cct)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="LF814_RS03405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="LF814_03410"
                     /product="tRNA-Arg"
     gene            19231..19306
                     /locus_tag="LF814_RS03405"
                     /old_locus_tag="LF814_03410"
     gene            complement(19473..19844)
                     /locus_tag="LF814_RS03410"
                     /old_locus_tag="LF814_03415"
     CDS             complement(19473..19844)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LF814_RS03410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LF814_03415"
                     /product="hypothetical protein"
                     /protein_id="WP_151014189.1"
                     /transl_table=11
                     /translation="MERDELISLLAGESPVIRACREALERGASFRIWDGVDGLVPANNL
                     ASTYRVREAISRDRGIPTLGFAAAVETLHALGEQPVRLGGVTQLDPPYYFQLFLAADAA
                     SVLACIGVDQKHQAQVQSS"
     gene            complement(19976..20293)
                     /locus_tag="LF814_RS03415"
                     /old_locus_tag="LF814_03420"
     CDS             complement(19976..20293)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LF814_RS03415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LF814_03420"
                     /product="hypothetical protein"
                     /protein_id="WP_151014187.1"
                     /transl_table=11
                     /translation="MSVQVREYGGVVVEQLTDAVGVASLCSLAASEPSRYPLLSGVDPY
                     DDTWFNSRQTARLATEIRSIIERSTDESVRAAAQAILQLASLLEATPRRPHHRQLLFNG
                     D"
     gene            complement(20404..21195)
                     /locus_tag="LF814_RS03420"
                     /old_locus_tag="LF814_03425"
     CDS             complement(20404..21195)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (22-125). E-value:
                     1.1e-24. Score: 79.3. Matches aSDomain:
                     nrpspksdomains_LF814_RS03420_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.4"
                     /locus_tag="LF814_RS03420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_03425"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_151014185.1"
                     /sec_met_domain="PF00561 (E-value: 1.1e-20, bitscore: 72.9,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Thioesterase (E-value: 1.1e-07, bitscore:
                     30.8, seeds: 16, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 4.8e-20, bitscore:
                     71.7, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRGFFAVENRRLSYLDFGGSGAPLLALHGHYNEASAFAPLAQALA
                     PHWRVIALDQRGHGASDRAESYERDDYISDVAAFHQHVKAGPAAVLGHSLGGVNAYQYA
                     GRYPDRVTALIVEDAGAAVDVDWSFTTSLPRHAPTRDALAAALGAAAPYLECSFRQSTD
                     GWGFSFDIDDTVASQKALSGDHWTDWVSVSCPTLLIRGTRSDELAAGHAREMIARRAGH
                     ARLAELPAGHVVHHDAQTQFAATVRAFLSDPAEPGEHFSTA"
     aSDomain        complement(20821..21129)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_LF814_RS03420_Abhydrolase_1.1"
                     /evalue="1.10E-24"
                     /label="LF814_RS03420_Abhydrolase_1.1"
                     /locus_tag="LF814_RS03420"
                     /protein_end="125"
                     /protein_start="22"
                     /score="79.3"
                     /tool="antismash"
                     /translation="PLLALHGHYNEASAFAPLAQALAPHWRVIALDQRGHGASDRAESY
                     ERDDYISDVAAFHQHVKAGPAAVLGHSLGGVNAYQYAGRYPDRVTALIVEDAGAAVDV"
     CDS_motif       complement(20884..20940)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_LF814_RS03420_0001"
                     /evalue="8.70E-05"
                     /label="NRPS-te1"
                     /locus_tag="LF814_RS03420"
                     /protein_end="104"
                     /protein_start="85"
                     /score="15.1"
                     /tool="antismash"
                     /translation="GPAAVLGHSLGGVNAYQYA"
     gene            complement(21292..21954)
                     /locus_tag="LF814_RS03425"
                     /old_locus_tag="LF814_03430"
     CDS             complement(21292..21954)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013473878.1"
                     /locus_tag="LF814_RS03425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_03430"
                     /product="DUF6882 domain-containing protein"
                     /protein_id="WP_230651217.1"
                     /transl_table=11
                     /translation="MPTFDRLFAEHVGTGLARQMALADLLGERDWQLDLPDGTVTFGTD
                     LRYRVQLLGTESHDDGTWLWAWANEASNIPPALLHLAGWLREYGNRQGVAELTAPTFPL
                     QRADGHRLALLASGLTGRCYYRGPYDGGAVFFHLDDAPPQITAPVRPERVLTVLTQVLQ
                     SFPVEHRVAVESFLHQQGWRLDRAPMSVTAQDRGGSVLRVDFDAMGRVSNMSGTVSA"
     gene            complement(22029..22202)
                     /locus_tag="LF814_RS03430"
                     /old_locus_tag="LF814_03435"
     CDS             complement(22029..22202)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013283846.1"
                     /locus_tag="LF814_RS03430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_03435"
                     /product="hypothetical protein"
                     /protein_id="WP_013283846.1"
                     /transl_table=11
                     /translation="MTVIPHGSDFETPEDEDETVAEPTDRHRLILAYIKTLSPIIAAVV
                     ACIGTLVAALVR"
     misc_feature    22193..22213
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.02"
                     /tool="antismash"
     misc_feature    complement(22402..22414)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 22.66"
                     /tool="antismash"
     gene            complement(22492..23577)
                     /locus_tag="LF814_RS03435"
                     /old_locus_tag="LF814_03440"
     CDS             complement(22492..23577)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020521599.1"
                     /locus_tag="LF814_RS03435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_03440"
                     /product="family 43 glycosylhydrolase"
                     /protein_id="WP_225319721.1"
                     /transl_table=11
                     /translation="MKFLRTRGGLVTLAAAALVVTTAAVAPAAAAPAGDLSTLADSSTF
                     PLADPDTLLAKDGSYVTYGTTVGAGTGARCGATGRLYVPVLVHGSGNSVGMADCASHDA
                     LPSGPGAWAEPGGAVWAPGVARFGSRFFMFYTASRKGTGQKCIGRAISDSARGPFQNQG
                     EWACPDAGRWALDANPFVAGGNLYVTYRDDAIASGAETGISTVRTDGEGRAIWDTRRDM
                     LKSTDITWDTAKTSGGTHVVENPSMWKAADGDWYLMYSGNNWDSARYATGIARCGATPL
                     PGSRCTPIREGVSRPFFGYTGSAGLNPIRGLPGNHQGPGGMDVFAAADGSERVVWHWWN
                     GSTRFPMTGVLTRPSTGFLVS"
     misc_feature    23593..23608
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.29"
                     /tool="antismash"
     misc_feature    complement(23595..23608)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.35"
                     /tool="antismash"
     misc_feature    23595..23609
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.4"
                     /tool="antismash"
     misc_feature    complement(23602..23616)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.2"
                     /tool="antismash"
     misc_feature    23611..23622
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.08"
                     /tool="antismash"
     gene            23806..24582
                     /locus_tag="LF814_RS03440"
                     /old_locus_tag="LF814_03445"
     CDS             23806..24582
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013283848.1"
                     /locus_tag="LF814_RS03440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LF814_03445"
                     /product="HAD-IIB family hydrolase"
                     /protein_id="WP_030273674.1"
                     /transl_table=11
                     /translation="MNDLRVVAFDLDDTLAISKSQIDRRMAELLGHLLTEVDVLVISGG
                     RFEQFQSQVLAHLDLTEEQRDRLHLMPTCGTRYYRWSDGDWRQVYAEDLTEADKARVVA
                     ALTESAQALGLWEAKTWGDIIEDRGSQITFSALGQSAPPAEKYGWDPDGDKKRRLRDAV
                     AAKLPDLEVRGGGSTSIDVTRKGVDKAYGMRKLLEHLDLKIDNVLFVGDRLDVGGNDYP
                     VKAMGIRCVAVTRWEETADYVEKLVDDLVQQRAERA"
     misc_feature    complement(24635..24649)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
ORIGIN
        1 ggtcgggccg gtcgtcgagt gcggcgaccg tcaacagttc ctgaacttcg gccgacacag
       61 tgcccagcca ttcgttcacc agtcggcggg cggccggcgg caggaccagg tcgtctacga
      121 gaccctgagc ggccggcagg tcggtggcgc ggctgcgggc cccggcgaat gcgagggcta
      181 gggccgggtt ccctccgctg cggatgtggg tctgcgtgac ctcgtagggg gttagccggt
      241 acggcgacag cagggttgcg acctgatcgg gtgtcagcgc cgggatgcgt accgcacagg
      301 ggtcctcgcc gcaccagtgg ccttcgctcc ccgggcgcca gattcgctct gcggctatga
      361 cgggaaggtc gggagccagg cgcagtgccc aacgcaagac ggccgcgctg gccgtatcca
      421 gccactgggc gttgtccacc accagtgtca gaggcggggt gtccagcagc agggtggcgg
      481 tcaaccggcg cagccgtaga gcggtcccgg cgggatcggc agagcccggc actccgacgg
      541 ccttgtcgat tccggtcgcg agttcccgcg cggccggcag cggttggagg gccagtgcga
      601 gttcgagcag tccggtgtag gggacctggg cgtcctgtgg gctcggagcc agccttagga
      661 caggcatgcc cagctgctgc ccgagtacac cggccgcagc ggtcttgccg atcccgggcg
      721 gaccgaacag caccacccga cgggcgccgc gcacgacgcc cggtaccacc ggcagcatgg
      781 tgccggtggc cccctgatgc gcattcactg ccgtcgcaga atctggcacc ggatcatagt
      841 gcgcccgacg gtccttcgcg caccagagca aggggttgcc ctgatttcgg ccagcctccg
      901 ccgttcctag tgtcatcgcc aaagccgagc tgtcaccggt tgccggagat cccatcaaca
      961 cgggccctgc tgccacaccc ctcaacccat ctcggcggga ggattgcgat gtatcgaaga
     1021 actgccatgg cggccgctgt cgcggttgcg cttaccctgg gcaccgtgac cggggtggcc
     1081 acccagtcga ccgcagccac cccgccccct acacccacgg ttgcgcagag cccgctgtcg
     1141 ctggcgatct ctgcagccga ccgcgctgcc gacggcggtc acgacgcgct ggcgaaaggc
     1201 cccttcgagc agtacgaccg tcgcatggtg atcccgtggg tggacggcct gttctccatt
     1261 gcctacgagc gcacctaccg gggcctgccg gtggtcggcg gcgacgccgc cgtactcgcc
     1321 gacggccggg gcgccatccg ggcgatctcg gccgccacca agacgaagat caacgtctcc
     1381 gtcgtgccga cggtcgccgc cgaccgcgcc gagcagaccg ccaagggcct gctcaccaag
     1441 gtcgaccagg tcgagtcgcg caccctcgtg gtgcacgtca aggacagcac cgcgcgactc
     1501 gcgtgggagg tcgtcgtcgc cgggcgcacc gcctcggcgc ccagccacct gcatgtcttc
     1561 gtggacgcgc gcaacggcca ggtgctggcc aagcaggagg acgccgcggc cggttccggc
     1621 accggcaagt ggaacgggcc cagcccactg tcgatcacca cgtcgcagtc gggcagcacg
     1681 tactacctgc gcgacaccac gcgcaccggc ctgaactgcc aggactacag caccagcacc
     1741 gtcttctccg gcgccgacga cagctggggc aacggagtgg gcacaagcaa ggagaccggc
     1801 tgcgtcgacg cactgtactc ggcgcagaag gaatgggaca tgctgtcggc ctggctgggc
     1861 cgcaacgggc acaacggcaa cggcggcagc tggccgatca aggtcggcct gaacgagcag
     1921 aacgcctact gggacggctc gacgatcacg atcggcaaga actcggcagg caactggatc
     1981 tcctcgatgg atgtggtggg tcacgagttc ggccacggca tggaccagaa cacccccggc
     2041 ggcaccagct ccgaagccgg cctcggcgaa gccaccggcg acatcttcgg cgccctgacc
     2101 gaggcatacg ccaaccagtc cagcgcctac gacgaacccg actacctggt cggtgaggag
     2161 atcgacctcg tcggcgacgg cccgatccgc aacatgtaca acccctcgct ggtcggcggc
     2221 cacccgaact gctactcctc gtcgatcccg aacacggagg tacacgcggc cgcaggtccg
     2281 ctcaaccact ggttctacct gctcgccgag ggcagcgcgc cgggcggcgg caagccgaac
     2341 agccccatct gctcgggcgg cccgtcgtcg gtcaccggcg tgggcatcca gtccgccgga
     2401 aagatcttct acggcggcat gctgctgaag acctccggca tgacccacaa gaagtaccgc
     2461 accgcgaccc tgaccgccgc gaagaacctg gactcctcgt gcgtcctgtt caaccggacc
     2521 aaggacgcgt ggaacgcggt cgcggtcccg gcccagaccg gcgacccgac ctgcaccggt
     2581 tccagcaccg acttctccgt ctcggtcagc cccacctcgg gcagcgtcaa cgcgggctcc
     2641 tcggtcaccg cgacggtcaa caccgcgacc gtctccggca gcgcgcagac cgtgtcgctg
     2701 acctcctcgg gtgccccgtc gggggtcacc gtgtcgttca gcccgacgtc ggtgacgtcg
     2761 ggcaacagct ccacgatgac ggtggcgacc acctccagtg cggctgcggg cacgtacacc
     2821 atcaccgtga ccggcaccgg ttcgatcacc cacaccgcgc agtacacgct cacggtcaac
     2881 ggcggcaccc ccggtggcac cgcgccggac atcgacgtcg ccaacgtgca ggcgcacctg
     2941 acacagctca gcaccatcgc caccaacaac ggcggcaccc gccgctcgac cggccagggc
     3001 tacctgcagt cggtggcgta cgtcaagggc aagctgcagg ccgccggctt caccgtcacc
     3061 gagcagccct gcacctccgg ctgcaccagc ggtgcaggcc cgaacctgat cgccgagtgg
     3121 ccgggcggta acgcgagcaa cgtctacatg ttcggcgccc acctggacgg cgtctcggtc
     3181 ggtccgggca tcaacgacaa cggctccggc tcggcggcgc tgctcgaggt cgccctcgcg
     3241 ctggccgcgc agaacccgac catgctgaac aaggtccgct tcggctggtg gaccgacgag
     3301 gaacagggcc tcaacggctc caagttctac gtcaactcgc tgaccagtac ccagcgaacg
     3361 gcgatcaagg cctactacaa cttcgacatg atcgcgtcga agaacggcgg ctacttcatc
     3421 aacaacatca cctcgaccgc gtcgcagccg atgaaggcgt actgggactc cctcagcctg
     3481 cagccggagg agaacgtcga gggccagggc cgttccgacg actactcgtt ccagaacgcg
     3541 ggcatcccga cctccggtta cgcgatgggc gccagcgcca ccaagacgtc ggcccaggcg
     3601 tcgaagtggg gcggcacggc cggtcagtcc tacgactcct gctaccactc ctcgtgcgac
     3661 accctcagca acatcgacgc caccgcgctg aaccgggctg ccgacggcat cgcctacacg
     3721 ctgtggaacc gggcggtcgg cacctcgacg ccgaccaacg acttctcgat ctcggccagc
     3781 ccctcgtcgg gcaccgtgaa cgcggggtcc agcaccacga ccaccgtcgg caccgccacc
     3841 acctcgggca gcgcccagac ggtgaccctg accgccagcg gcgcccccac gggcgtaacg
     3901 gtctcgttca gcccgtcgtc ggtcacctcc ggcagctcgt cgaccgccac catcgcggtc
     3961 ggctcgtcgg tggccggcgg cacctacacc atcaccatca ccggcacggg gtcggtgtcg
     4021 cacagcacca cgtacacgct gaccgtgacc ggcggaccgg gcggctgcac cgccgcccag
     4081 ctgatcctca acggcgggtt cgaaagcggc acctcgccgt ggaccggctc caccggcgcg
     4141 atcggcacct ctatcgggca ggtgccgcgc agcggcaccc ggtacgcgtg gctcggcgga
     4201 tacggctaca ccgcgaccga ggccatcagc cagaccgtca ccatcccgtc gggctgcacc
     4261 agtgcggtac tgacctactg gctgcacatc gacacgagcg agtacggggc gctcgcctac
     4321 gacgtgttca cgatcaaggc caacggcacc accgtggcgt cgctgtccaa catgaacgct
     4381 gccacgggct acacgcagcg caccgtcaac ctcggcgcgt acgccggcca gacggtcacg
     4441 ctgaccttca ccggcaccga ggacgcctac ctgcagacca gcttcgtgct ggacgacgtg
     4501 accctgcaga tcggctgagt tcaacggcag ggtggggcgc tcgccccacc ctgccgcagg
     4561 tcctgcgccc ctgttccgct gccggaccgg accttagcct gaatccgtgg attggattct
     4621 gggtgcgttg tcgggttgat ctagccgatt gggggtgtga tggatccgct ggccctggtc
     4681 tccgtagaac gccaagtaac ccggctccgc cttgacctgg cgagaggcga agtccatcgc
     4741 ctccgggcgc agatctgccc aacctcgcgg gaagcggccg taccggtcgt agaacctccg
     4801 caacagcgcg aacccggccg tatctcgcca tgcttggacg caaccaggtc cagctcagca
     4861 gggacaaggg tccagtgctc gaccagctcg ccgatgctca gaggagatcg actcacagcg
     4921 gtcaaccacc gtggcagcga tcagggaccg cgcagacccc caaaaagatc aactatttgg
     4981 cccctggtcg caagatcggc gtggttggtc gtgaagggcc cgtcggcgtg tgaccaggtc
     5041 cagcgaagcc gtcggtgggt cagccacgca ctagcctggc cggcgaggtc gcggtgccgg
     5101 cgctgggtcc tgttggtgtc gccgccgtcg gtggtgaagg cgagcagggc gtagccgccg
     5161 gggatgccgg cgtggggctc gccggggtgc cggctgccgt cgacggggag gtgcacgctg
     5221 gccagggccg gtgcgccctg tccgggcagg gtttgcagca tgtggacgcg gccgtggtcg
     5281 accaggtgcc atcggccgtc caggggcagc ctgagcacgg tgcgggcgtg ggcgaacagt
     5341 tcgtaggcgt cgacggggtc ctgcacgacg agggtggtgg tcgcggtcat cgtggtcacc
     5401 gggcccagat cgccagggct gcggtggtgg cggcgccggc gtacccggcg agcagcagcg
     5461 gcacggcgcg ggagatggcg gtgtacttgg cccgtacggc gcgggagagc caccacaact
     5521 cgcgggcgcg tgcgaggggg gcggtctggg ctcccgggtc ggtgtcgcca ccgacaacgc
     5581 ggaccaggac gtcctgggcg gtgtcggtgt cggcgtaggc gacgaacccg aagtccccac
     5641 cccgaaatcc cggtacgcga aacccgcgtc cggcaccggt ggggctactg aaccgccgaa
     5701 agcccttgcg gcagggctgg cgccgcgcgc cctttatggg catcaccgca cgctcttccg
     5761 cgctcgtcga agagggccga tgcccaccga actcgcacat cgtgtccggg gtgtctgtcg
     5821 gtgacggcgg caggctgagg ttgccgtgcc cgttgggccg ggagtgggga tggctgaagt
     5881 gtgttccgcc gtgatcgtgg ctgacgttcg aggtgccaac cccgctcccc ggttttcgac
     5941 acaggcgccc tctctgccag gccagcacgc cattcgcacc agctccacgc ccaggtcgcg
     6001 tgcgatccgc taacgtcgaa tcgccgtgcg tcggggcgcc gcaacagtcg gctcgacgca
     6061 ggtcgatgcg aacggaaagg cgagcccatg attgatcgcc aggatcttca acaggccagg
     6121 gacgatctcg gccgtaagct cgccgccctg cgtaggtcga gggggactca ttcaggaagc
     6181 cctcgcacgc caggtgcaca cgacgcgcag caccctggga atggtcgagc ggggccggca
     6241 ggtcgtggac cggatcttct ggctgcagtg cgacaccctg ctggacgccc agggcgagct
     6301 actcgccgcc tacgacgcct accgacacct ccagtcccgg ttccaggcac agcaggccga
     6361 ggcggcacag cgggcgcggt ggggagcggt acccgaggcg gtgatggcag ccggcgaggc
     6421 cacaggcgaa aggtacggcg aagtcggcga caatcgacgc ccgccggacc ggttccacgg
     6481 cgagcgcccg gaggcgggcc gcaccacacg aaccgggcag gtctcagtcg tcaacgcggt
     6541 agcaggccgt ggcgaggaag ccgaccacga tgccaggtcg cgactgctgg ccgagctgcg
     6601 ccggcacctg ctcgcacctg ccgcaccgaa acagccggtc gagcctctca cgctttcgga
     6661 ggtccgtcag cgggtggccc atctccatag cctttaccag cgtggcaact atgccgaggc
     6721 ggtccgggcg ttgcccgaca cgttcgagca ggcgaacctg ttgacccgga cctgcaccgg
     6781 cacgcagcgc gccctggccg tcgggtcgct ggcggcggcg aatctcgccg ccgccaaact
     6841 caccgtgaaa ctcggcgatc ccagccttgc ctgggtggcg gcggaccgtg ccgctcgtgt
     6901 cgccgccgag caggccgagg atgttgcgct cgtcgctgcg gcggcgttct cggtgggtac
     6961 tgcgctgctg gcgatgccgg accgcgtcgg cgatgccgag gaggtggtgc tggccgctct
     7021 cgatggtgtg acggacacga gggactccgc gtcgacgggt ccgcgtgtcc tgtcggccca
     7081 cggggcgttg actctgctcg cggcgctgat cgccgcccgg caggcccagc ccgccgctgt
     7141 cgagcggcac ctcgacgacg cgaacgccct ggcccggcgg ctcggcgccg atcgtaacga
     7201 cctgtggacc gggttcggtc cgacgaacgt gatgatccac cgcatcagca tcgccgcccg
     7261 aacggaccag cctcagctgg cgatccacct tggagaacag ctcgacacct cgtcgctgcc
     7321 ggcggccctg gtgagccgcc gcgcccgggt ccacctcgac ctcgccgccg cctacgcctg
     7381 ctcgcccggc aacgatcccg cagccgtgct gcacctgctc gaagccgaac gcatcgcgcc
     7441 gcagacggtg cacgtgcacg gccggacgcg ccatctgatc ggcgacctgc tcacccgtga
     7501 gcggcgcgcc gtcacccccg gcctgcgggc actcgccgaa cgcgccggaa tcgccgcgtg
     7561 acgtccggat ccgcgaatgc ccgtctgctc tacctggtgg tctgtgccgc gccaccggcc
     7621 cgccgcatcg tcgagctggt cgaggcggtg cggcgcgacg gctgggatgt gtacgtcatc
     7681 gcgaccgaaa ccgcgcacac ctggcttccc aacgatcggc tggccgccgt tacgggcagg
     7741 cccgtcagct accggcagcg gcatcctgac gaaccgagcg tcctgccacg cgccgatgcc
     7801 gtcgcggtcg ttccggcgac gttcaacacc atcaacaagt gggccaccgg catcaacgac
     7861 agtctggccc tcggcatcct caacgaagct ctcggcgcag gcatgccgat catcgtctcc
     7921 ccgtacgtca aacccaccct cgcccgccac cccgcgttcg acgcccacct gcggctcctc
     7981 gccgaccacg gcgtacgcct caccgccacc gaggcgctgc gaccagctca cgacgatcag
     8041 cccttccgct ggaacgtgat cctcgacgaa ctccacaggc tgtccgcccg cctgtcgtag
     8101 tcggcccccg agaggcgctg gggccggtct gaccgtgtcg aaatcccgtg tcgagggtgt
     8161 tcgacacggt cagaccggcg ttgagtggtg gacatgaccg ctcggcgccc gccgctcagg
     8221 ggtccccggc accgcccaac ccgaggggag ttgatccgtg tgaccctgta ccgcagtttc
     8281 tcgccgctgc cgaggaatcc gggaccgctg gtggccggga cggctcggac ctcacgttga
     8341 ctgcggcttg atcgaacccg ggccgccttg cgtcgccttg ccggttgggc acccggtgag
     8401 ttcggcctgc gtcctgccca gcaggggaac agtcctcggg cgtctgaggc cgtgttcgtc
     8461 cttggcggat aacggaaagt gcgggccgtc cgcaacggcg gcggtcctga cgaacaggag
     8521 agtgacgcgc acatgagcgt cgacacgatg agcagcgacg acctccgtga cgcgatggtc
     8581 gaccagctgg tcgctgacca tgcggccaag gggctgacga tgcggcccga ggtcgaggcg
     8641 gcactgcggg tggttccccg cgagctgtac acgccgggtg tcccgatgga ggaggcgtac
     8701 cgcagcgaca ccgcggtcgt caccaagcgg ctcggtgatg agaccgtcag ttcggtgtcc
     8761 gcgccgtggc tgatcgcgga gatgctcggg caggcggctg acgccctcac cggtggcctg
     8821 cacggccggc acgtgctgga gatcggatcg ggcggctaca acgcgtcgct gctgcgcgag
     8881 ctggtcgggc cgtcgggttc ggtcacgacc gtggacatcg acccggaggt gaccgagcgg
     8941 gcggtggcgt gtctggcggt ggcaggttac ggcgatgtca gcgtggtgtg cgcggacgcg
     9001 gagcagccga tcgacctggg gcgctgctac gacctgatca tcgtgacggc cggggcgtgg
     9061 gacatccccg cggcgtggat cgcgcagctc gccgaggacg gcgtgctggt ggtgccgcta
     9121 cggacgttcg ggatgacccg gtcgtgggcg ctgcgccggg tcggtgaccg gctggtcagc
     9181 cacagccagc gcctctgcgg gttcgtggcg atgcggggca ccggagccca cgagatgcgg
     9241 tatgtcgaca tcgccgccgg tgtccacctg cggctggatg agggccagca ggtcgacccg
     9301 gaatcggtcg gtgggctgct gtcgcagccg caggagcagg catgggcagg ggtgggcctg
     9361 ccgcctcgta gcgtcctggc cgacctggac ctgtggctgg cggcccgcct cgccgatgag
     9421 gtcgaccagt tcgtggtgct ctcggcgcag caggaggccg tcgacgccgg catcgtcgcc
     9481 cctgcctggc ggttcggtac gcccgccgcc ctgcacgagg ggacgttctc ctaccggtcg
     9541 acgctgcgct ggaccgacga cacgttcgac ctcggcgcct gcgctcacgg gcccgacgcc
     9601 gccgcggcgg cgggacggat ggccgggcac atgcgcgcgt gggtggacgc tggcgagccc
     9661 tctccggtgc tgcacgtcct acccgcaggt actcccgacg gcgccctgcc ggccgggacg
     9721 gtgctggaca agcgacacag tcgcctcgtc ctcaccttca cctccgcata ggaaggaaca
     9781 cgcgagtgga gaccatggaa ctcgaggagt tcgacctgga catcaccctg gtggacgccg
     9841 gccccgctgc cagcgggtac gccaccagca ccgacgacgg ctgcggctcg ggcaacacgg
     9901 gctcgaacgc ctgttccggc ggcagcaagt aaccgtccct gacgatccac cccgggcccg
     9961 gcgtctccag cgccgggccc ccgtcttcga gggtgcgttc atgttcccca cggccggtgc
    10021 ggcgctgatc agagttgccg cctaccccag cggtctgacc ctgcccgcgt ggcccgacct
    10081 gacgacggat cagcccgagc agtggcggca gtggctggcc gcagtgtggg cgctgccggg
    10141 attcgccacc gccgtcgccg ctgccacacc ccagttggcc gaacagatca cccggaccgt
    10201 ggccagtgcg ccgaccaccg accgccggtt cgggcgcatg gtcgactcga cggtccggta
    10261 cctgctgagg tggaccaccc gggcgacacc gttcggcacc ttcgccgggg tggctccggt
    10321 cgagttcggc gcccgcgcat cggttcggtg gggcgaggcg catcaggtgg tgacccgccc
    10381 tgacgggacg ttcgtcgccg agcacaccgg gcgcgccgag caggacctgg cggcgctgcg
    10441 cgacgtcgcg gtggtgacga actcggtggg gtaccagcgc ggcgaggtgt gggtgctgcc
    10501 ctgcctgcgc ggcgacggcg accgcaggtg ggacatagag atccgtctga ccaggccggt
    10561 gcgggcggcg atccgcgcgg cgcgttcccc ggtcatgttc ggtgacctcg ccgcccgggt
    10621 cgccgggccg ctgcccgccg ctaccggggc ggccgaacgg atgttggcgt cgctcgtcca
    10681 ggcgggtgtc ctgctgtcgg cgctgcggcc ggcgacgact gtcaccgacc cggcctccca
    10741 cctggcccgt cacgtcccga tgcccgatcc cggcgaccgg gtcgcggtcg acctgcgtgt
    10801 cgacgcctcg gtgacgctgc caccggcggt gctccacgag gcggcccgtg ccgcgtcgac
    10861 gctggtggcg gtggcagcgc ccctgccggg atgggcggaa taccacggcg cgttcattca
    10921 gcggtggggc ccgggcgcgg ccgtgccgtt acgcgacgtc ctgaacgttc tgggctttcc
    10981 cgccggatac cggggttcca cccggcgtgt acctgcggtg ttcaccgccc gcgaccggct
    11041 cctcgcgcag ctcgcccagc agtcggcgct gaacgactgt acggaggtga tcctcgacga
    11101 cgagctgaca ggccgcctac gaggagatga cgaccggccg ccgatcccac acaccgaact
    11161 acggttcacc ctcgccgccg cgaccccaca ggacctggac cgaggcgcgt tcacgttgac
    11221 ggtggtcagc ggagcccgcc acgccggggt cgccgccggc cggttcctgc acctgctttc
    11281 tcccgccgag ctggcgtcgt tccagcacgt ctaccggaac ctgccgaccg ccctgcccgg
    11341 cgcggacacg gtgcaactgt ccggcccgcc gctggatgcc cgcttggccg cggtcgcccg
    11401 gacacctgcg gtgctgcccg tcctgcccgt cggcgacttc cacccggacc cgccgtggac
    11461 gctcgcggac ctcgcggtga ccggcgacgg ccagcggctg tggctggtgt cgcggacctc
    11521 cgggcgaccg gtcgagccgc tgctgctcaa cagcgtgctg ctacccgacc tccagcagcc
    11581 cctgatgcgg ttcctgaccg agatctggac ggcgtggacg gctccgtgca gccgattcga
    11641 ctgggggcac gcgcgtagcc tgccgttcct gccacgcctg cgacgcggac gcagcatcgt
    11701 gcaccccgcc cgctggacca tcgaccggac cgcgctcccc gcccgcaccc tggcatggtc
    11761 ccactggcgc gacgcctggc agcgataccg tgaacagcac cggctcccgg acgaggtcct
    11821 ggtcggcgcc gacgacgtgc aggtacgtct ggacctgaac gacaacaccc acctggcagt
    11881 gctgcgccgg cacgtcgacc ggcacgcccg caccaccctc accgaggctc ccggcccggc
    11941 cggctggatc ggcggccgac ccgccgaact cctcctcacc ctcgcgcaca cccgtccggc
    12001 cacccacccg agccgaccag cgcgggccgt gaccgcacaa cagcatcggc ccggccagtc
    12061 accgtggttg gaggcccgcc tgtacggccg ggccgacgac atcctcaccg acctcgccca
    12121 ccggaccggc aacctcccgg cggcgggctg gtggttcctc cggtacccgg accccgagcc
    12181 ccacctgcgg ctacgcatcc cactccagga caccaccttc gctgccaccg ccgcatgcct
    12241 cgccgaatgg gcgcaacaac tggagcacaa acgcgtcctg cacgactaca gcctgcgcac
    12301 ctaccggccc gagacccgcc acggcaccgg ccccaccctc accgccgccg aagcggtctt
    12361 cgccgctgac tcccgcgcca ccctgcagcg gctgaccggc gaccgccagg ccagcaccgc
    12421 cgccacgatg atcgccatcg cggacgcctt caccggcgac gggccgcgtt ggctcgccga
    12481 acacgtcccc caccaccgcg gcccccgact cgaacccgtc cagctcgacc tcgcccgcac
    12541 cccctaccgc gacgacgacc tggacaaggc actggccacc taccggacac tggcccacgc
    12601 cgacaacctc gacctcgacc aggtactgac cgacattctg cacctgcacc acgcccgcat
    12661 gatcggcgtc gaccccgcct ccgaacggca ctgcctccgc ctggcccgcg ccgtcgcccg
    12721 cacccgccag gcgacgccgt gaccgcagca cagtccctcg ccgaaggggc ggccggcgtc
    12781 gcccttctac acctggaaac cggcaaccgg cccgccgccc acgcggcact gcgggccgcc
    12841 accgccaacg gcgtcagcat cgccgcaggc gccagcctct tctacggcgc acccgcactc
    12901 gccttcgtcc tcgccacccc caaccaaccc ggcctcaccc gagcacgatc gatcgccgcc
    12961 accgggaccg ccacggtcac ccgccgacgg ctgcacgccg cccaccgccg catcgactcc
    13021 caccagcggc cccactacgc cgagtacgac ctcatccgcg gcctgaccgg cctcggcgtc
    13081 gccctgcacc gcctcggcga ccacgacctg ctccgccagg tactcaccta cctggtccgg
    13141 ctcaccgaac cggtcaacga cctccccggc tggtggtgcg cgaacggacc cgaccgacac
    13201 cagccaccac caccaggagg ccacgccaac cacgggatcg cccacggcat caccggccca
    13261 ctcgcgctac tcgccctcac ccaccgcgcc ggcatcaccg tcgacggaca caccgaggcg
    13321 atcctgcgga tatgccgatg gctggacacc tggcagcagc acaccgccga caccatctgg
    13381 tggccgcaga ccctcaccct cgacgacctg caccacggcg cacccgcaca acaacaccca
    13441 ctacgcccct cctggtgcta cggcaccccc ggaatcgccc gcgcccaaca actggccgcc
    13501 ctcgccctgc acgacaccgc ccggcagctc ctcgccgaga cggcgttcac cacctgcgtg
    13561 aacgaccccg cacagatccg ccgtctcacc gaccgcagcc tctgccacgg caccgccggc
    13621 ctcctcgcca ccggccggcg catcgccgcc gacgcactca ccccgacacc cctcgcccca
    13681 ctgacccgcc tccacctgca cgccaccccc gccgcggacg aacccaccgg actacttgac
    13741 ggcacagccg gtcacgccct ggccgcagcc tccacaacct caacctcgtg ggacgcctgc
    13801 ctcctactca gctgacgaaa ggcccgccat gaaggagacc ccctggcaac aggtgaacat
    13861 cacctaccct ggccagagcc gccacgaacg cgaacaacac gcgatacccc acctccaccg
    13921 cgtcctaccc gccgccgaga ccgccggcct catcacctcc tggtggttca tccgcaaagg
    13981 accgtggcgc atccgctacc tgcccaccac gcccgacacc gaccccggcc cggtacacga
    14041 cctgctcacc ggaacgcgcg cctggaccag cgacatctac gaacccgaga tccacgcctt
    14101 cggcggcccc gacgcgatgg acaccgcaca caccctgttc caccacgaca gccgccacct
    14161 cctcacctac cttcaccatc agccggcaga ccgacgggaa cgctccctca tcctgtgcac
    14221 ggcactcatg cgcgccaccg gactcgacct caacgaacaa ggcgacgtat gggcgcgagt
    14281 cgcccgacac cgcctggaac accgcacctg gccccccgcc gccgaccccg ccacctggga
    14341 agccttcacc ggcaaggtcc gtcacctgca actcggcacc acccgcacca ccagcgactg
    14401 gcagaccgcc ttcgagaacg ccggcacagc cctccgccac ctacgcgaca caggaaaact
    14461 cacccgtggg ctacgcgccg tgatcgcaga gcacgtgatc ttccactgga accggatcgg
    14521 gatacccgcc acaacccagg ccgtcctcgc ccaagcagcc gcggaagcca tcttcggccg
    14581 tgcccccgtg ccgccaggcg agcagtggcc acgcccggtc gaacccgtac caccatctgc
    14641 ggtaccgcca acagaggtcg atgcgcccag tcgcgcggcg cttgcaagtt caagacacag
    14701 cagactcctc acagaggggg ctagtgccca atggtcgtga agcgctggcg gggccggaca
    14761 catcgtccgg ccccaagtaa agtgctggtg cgtgatggtt gaaccgcttc ggtcgatcct
    14821 ggccttggcg tccgaagtgt gcagtcgggc cagttatcgc cgacctttcg tcacgattgc
    14881 cctaactgct agaaggatca acgggaccag tatgggtgta ggcacggaaa tggcgtcggg
    14941 aatttcattc accgaagcgg caacccatgt aaccgctgcg gcgattgcgg ctaccagtag
    15001 cccggatagg gttagggcgt gtcgagccgt tcgcttcgaa ggcagaaact ttatctcaat
    15061 ggcgaatcgc caccaggttg cgaagaaatt cccttccgtt gatcttcctg ttcggtgatg
    15121 cgcccagacg cgtgccttgt ccgacggttc ggactcgatg gggtcagtgt gatcggccag
    15181 gttgagctct tggtcaatct gctgggacgg gcaacgcccc tggttcactg cataacccca
    15241 atcgtgcaag cgaacaagct tcacttcctt cctgcgtgtt ggatcgggtg cggtcgctgt
    15301 gcataaagac tgaccgacat gggtcgtagg acgagactcc taggcccatt gtcatggtct
    15361 caacgtgcat cgcaagaccc gtcgcacatg gtgtgcgatg ttccagcttg gagggacggt
    15421 tgactagcag ccctgaaccc gtgagtctgt tgacgggcgc ccattggtaa cgcgaagtgt
    15481 cttaaatttt cctgggaact gtcagcagcg ataaagagta ccgggcatgg gagaagggga
    15541 tatatatgcc agcgaagggg tctgttgaag cgggcaatgg cggcgttccg aaacggcgtg
    15601 agtccgatgg cggcatcacc cctccggcag ttgcgtctgg aggtgcgagt gggagcagcg
    15661 ggccgctaac ccgtgtaacc gtcaatttta ctcaaaggtc aatgttggcg ctcgatagtg
    15721 ccgtccggaa gtcgggagat accagaacgg acaccatcaa ccgcgcaatt caagtatatg
    15781 atctagtgca agatgtccta aagcgcggcg atggccgaag cctgctgatc aagtatccga
    15841 atggcgaatg cgagcgcctg ctaatgatgt gactagccgc tcggctctta acgcattcgg
    15901 gcagatgttg gacttgaatg gcaccaattc ttcccaaggg tagagcagga gcagtcaccg
    15961 ccgggtatag aaagtaggca gggctgacca tctcgcggcg gcggccattg gcgacacggc
    16021 tgctggggaa agtccattcc gtctgtccgt tgtagtcgtg gccgcgcgca gcgctgcatt
    16081 atcctgcctt ggaggccctc ttgccggcga gaccccttgc ggcatcgttg taaacccctg
    16141 tgctcgtaat cgacggagcg tcgctcgtcg actttgccgg cttcgtctac gagttctcgc
    16201 agctgctctg tcacgcaacc cgagcggaag cctcgatgcc ttcagcgaca tcctcttcga
    16261 gcaggaccct gggaggctgg ccgttctgct gaccgcagtc ggtgtgccag gcatgccgct
    16321 gccagaggcc ttgtcggata cgcactcgag ttcgaaccga tcgtccctcg cgatcttgtg
    16381 gagactcgga tcagtgcggg cgtctggcaa ccatgaaggc cagcgatgtc accgtcgtcc
    16441 cgacctagtc gcctagcgtc tgtcgacctg cacgaaggtt gttgcggcgg cgacgccttt
    16501 ggcgactgcg tggggtagcg gcacgttgtg agcgagtcgt gcggcgaggg tgccgaggaa
    16561 ggcgtcaccg gccccgctgg tgttgatggc cttgacgtgt gatgcgggga cgagtgcggt
    16621 gtggtcggca tcgctgtagg cggcgccgcg agcgccagcg gtcaccacca ccgctcgtgg
    16681 gcccagcttg cggagttcct gcgctgcgat cgacggattg gcatggtggc ggcccagtat
    16741 cgctgccgct tcggcctcgt tcgaaacgaa caggtcgagt ggggccaggg cggtcagacc
    16801 gagcgaggga tgtggcacga ggttgccgat gagcgtctct gcgtggtgat gccggaagac
    16861 ggcgtcaacg gcatcgggct ggagatcgag ctgggttacc acgatcggag ctcgtagctg
    16921 ctgaagtgcg ttgcgcacat gctcgctggc gagctcagtc tctgtggagt gtgcgaggac
    16981 gatgtagttc tcgccgtcgg gggtgatctc gatgatcgcg gtaccggtcg gagccgatgg
    17041 cacgacttga aggaaggaca tgtcgatggc cgcgttggtg agggctcggc tcagggaggc
    17101 gccccattcg tcgtcgccga cgttgctgat caggctggcg cggacgcccg cttgtcgtgc
    17161 ggccaaagcc tggttgaggc tcttgccgcc cggtgtggtc gtcgcgggtg acgaggcgaa
    17221 cgtcgtccgg ccagcgacgg gccgttgggg gatccgcacg gtgatgtcga tgttggcgcg
    17281 gccgacgaag gcgacatgcg gcgtacggac ctgatcgggt agttggtgac tcatccgctg
    17341 gtggccagct ggtcgaggag ctgtcgcact tccggctggc tggagaaggg ttcgagtcgc
    17401 cgggccaggg tggtgacgtt tcggcggacc cgaaccgagc ccgtcgtggt agccgtggtc
    17461 aacgcttcag ccgcgacggt ggcggcctgg cctggttccg aagccgccag gtaggcgtgc
    17521 gccgtgcggg agaggtacac gccccgttcg cgtcggtagc ggtcgggcca cgtgttgacg
    17581 gcgttggtga agctgtcgat ggcccgacgc ggttggttga ggcggagcca tccctcgccc
    17641 tcctgcgccg caaggtacgg ccgggtgcag aacgaaccga gggcactgct tcccccgctc
    17701 ggcggcctgg cggtcgccac gagtgtgtgg gcacgctcga ccgcggcctg gaaagcggag
    17761 gcgtcctgcg cgatggcgct gccgtgcgcc tgctggatgg cggcgaaggc gtgcaggagc
    17821 gggggcgtgt cgggcaggcg ggaagcggca cgggccagcc cgacgacaca gtcctcgtcc
    17881 ccggttccca ccatccgctg tgccttacgg gtcaggacgt acgcccagaa ctcctgatcg
    17941 tcggcttcct gcgccatgct tcccgcgcgg tccagccagc ggtcgcccgc ggcccggtcg
    18001 ccgagatcgt cgctgagcca acccgcgaac tcgctccacc gtgcctcggt gctgagaagc
    18061 cggttacgaa gctgtccacg tgtctgccga cgcagggcgg cgatcagcgc gatctgctgt
    18121 tcgacggtcg acaggatggt gaggccaccc agccggtcgt ccgcttgtac gaggagcgcg
    18181 cgaagctccg cgaagtgatc gacaacggca gggtcgacgg accgtgggtg agaaacgcct
    18241 gcggtggtga caaccggcac ggcggtgagg ccagcggcca gttccagcag agccctccgg
    18301 cttacccgca atgacatcgc ctgcccatcg gacatgaccg caagcgtaac cgcgtcacca
    18361 tcgtgaaagt ccgtctcacc tgccaccgcg gcaccggcga cccgcgcgag tggtgccgtc
    18421 aggccgttcg gaccaccggc cgtcagatcc gtggcggcga ggtcgcgcaa cgactcccgt
    18481 gccggatccg tcaccgggac accgtgagtg ccagccggta gtgagcggtc ctcgacttcg
    18541 ccccaccgca tgcgttgtgc cgcttcgact ttctcctgat caagctgctg cttcaggcgc
    18601 cgatagtcgt cgtagtcggc cagcaactct ccaccagcgg ctagggccgc ttcacagcgc
    18661 tgccagaaga tccggtccgg gcattgctgc ccgcgctcga cgcccgcgat cgtggtccgg
    18721 gaaaccggca cccgcctcgc caatgccaac tgggtcagcc cacgcacgtt gcgccaggcg
    18781 gcaagccttg cacccagtgc ccgcttcgca tcgtctaccc gctgcggatc gatcatgacg
    18841 cccgtccctt cacaaccccg tacggacacg acggctgcat tgacgcaaag cgacgttacc
    18901 gtaaccgatc tccgccagaa ccggccagcg cctcaacaac cccggcgccg acgtccttgt
    18961 ccgcgccgag caacgtctat cggcgggcga cccgagaccc gactccggac cttcgatgat
    19021 gtgcgcggtg tgtgctcgag agcggatgcc accgtggggc aaccggtgcc accggatgcc
    19081 acggcgggtc aacgggccgg gtcgctgccg gggtccgtgt gctcggggtg tggtcatcgg
    19141 tcggccctga ccagggcgac gacgtgggtg aacgtgggcc actccctgcc accccgggtg
    19201 aaccggcagg ccgctagact gggcactcgc gccctcgtag ctcaggggat agagcatcgg
    19261 tttcctaaac cgtgtgtcgc aggttcgaat cctgccgggg gcaccaggtc agacgcttga
    19321 tcaacgatca ctgttccgcc ttccagggct tgcgcgcccg atcgcctcgc caccttcgcc
    19381 cggctcgcat ccaggagctg agcgacatca gcgtcccgac cgtcgacggc acgggcgtag
    19441 tggcgagtcg tcacgccggc gttggctgcc ggtcacgagg actgaacctg cgcttgatgt
    19501 ttctgatcca cgccaatgca cgcgaggact gaggccgcgt cggccgccag gaagagctgg
    19561 aaatagtagg gagggtcgag ctgcgtcacc ccgccaagtc gcacaggctg ttcaccgagc
    19621 gcatggagcg tctcgacagc cgccgcgaac ccgagcgtcg gaatgcctcg atccctgcta
    19681 atcgcctccc gcacccggta cgtggacgca aggttgttgg cggggaccaa tccgtcgacg
    19741 ccgtcccaga tgcggaacga cgctccccgc tcaagggcct cacgacacgc cctgatgact
    19801 gggctctcgc cggcaagcag agagatcaac tcatcgcgct ccacacgacg acggtacagc
    19861 cattccgtac cgccaagccg tcccactgag tcaggccctg gcggacgacg acggacgggc
    19921 tgaccaggag cgccattgcc ggatgacctg gtgccggctg gcagaatctt cgcggtcaat
    19981 ctccgttgaa caggagctgt cggtggtggg ggcgtcgggg cgtggcctct aggagcgatg
    20041 cgagctgaag tatcgcctgg gcggctgctc gcacgctctc atccgtggat cgctcgatga
    20101 tcgaccgaat ttcggttgcc agcctggccg tctggcggct gttgaaccac gtgtcgtcgt
    20161 aggggtcgac tccggagagc aacgggtagc gggacggctc cgatgcagcc agggagcaga
    20221 gagacgcgac gccgacggcg tccgtaagtt gctctacgac gacaccgccg tactcccgga
    20281 cctgcacact cattcccacg gcctcatcgt gccggacccg agtgatcaca ggatgagccc
    20341 ggtccccctg agcaccccga tcctgccgat caactggccg ctcgtagtga gatcgcgcct
    20401 ggatcaagcc gtactgaaat gctcccctgg ctcagccggg tcggacaaga aggcgcgaac
    20461 agtggcggcg aactgtgttt gagcgtcgtg atgcaccaca tgaccggccg gcagctcggc
    20521 aaggcgagca tggccggcgc gacgggcgat catctcgcga gcgtggccgg ctgccagttc
    20581 atcgctacgc gttccacgaa tcaggagagt cgggcagctc accgaaaccc agtccgtcca
    20641 gtggtcaccg ctgagtgcct tctgggacgc caccgtgtcg tcgatgtcga acgagaagcc
    20701 ccagccgtcg gtggactggc ggaaggagca ttccaggtag ggtgccgccg cgcccagggc
    20761 cgcggccagt gcgtcgcggg ttggcgcgtg gcgggggagg ctggtcgtga acgaccaatc
    20821 gacgtctacg gccgcgccgg catcctcgac gatgagcgcg gtgacccggt cggggtaccg
    20881 cccggcgtac tgataggcgt tcactccgcc gagcgagtgg cccagcaccg ccgcagggcc
    20941 ggctttcacg tgctgatgga acgcggcgac gtcggatatg tagtcgtcac gctcgtagct
    21001 ctcggcacgg tccgacgctc cgtgcccgcg ctgatcgagt gcgatcaccc gccagtgggg
    21061 tgccagcgcc tgggccagcg gggcgaatgc cgacgcttcg ttgtagtgcc cgtggagagc
    21121 caggagcggg gcgccggatc caccgaagtc cagataggag agccttcgat tctccaccgc
    21181 gaaaaaccca cgcatgacct gggatgctag acccggtcgt tgtcggcggt cgggcggcgc
    21241 tgagcggttg gtcgccgcgc ccgttgcgtg ccaggcggcg ccagattccg cctacgcgct
    21301 gaccgttccc gacatgttgc tgacccggcc catcgcgtcg aagtcgacac gcaggaccga
    21361 cccaccccga tcctgcgccg tcaccgacat cggcgcccga tccaaccgcc acccctgctg
    21421 gtgcaggaac gactcgacgg cgacgcggtg ctccaccgga aaagactgca ggacctgcgt
    21481 caggacggtc agcacccgtt ccggccggac cggcgcggtg atctgtggcg gggcgtcgtc
    21541 gaggtggaag aagaccgcgc cgccgtcgta cggcccgcgg tagtagcagc ggccggtcag
    21601 gccggatgcc aggagggcga ggcggtgtcc gtcggcgcgc tggagcggga aggtgggcgc
    21661 ggtgagctcg gcgacgccct ggcggttccc gtactcgcgg agccagccgg cgagatggag
    21721 tagcgccggc gggatgttgc tggcctcgtt ggcccaggcc cacagccagg tgccgtcgtc
    21781 gtggctctcg gtgccgagga gttggacgcg gtaccgcagg tcggtcccga acgtcactgt
    21841 gccgtcgggc aggtcgagct gccagtcgcg ttcgccgagc aggtcggcca gcgccatctg
    21901 gcgggccagg ccggtgccga catgttcggc gaagagtcga tcaaatgtcg gcatcgccgc
    21961 agtgtgccag accttcgggt accggacggc cccgcgtccg gccggagccg gagcgcgggg
    22021 ccggcgggtc agcggaccag cgctgccacc agcgtcccga tgcaggcgac gacggcggcg
    22081 atgatcggac tgagcgtctt gatgtacgcc aggatgagcc ggtgccggtc ggtcggctcg
    22141 gcaacggttt cgtcctcgtc ctctggtgtc tcgaagtctg acccgtgagg gattacagtc
    22201 aacgtgactc cttccgttgc agcggtggag tcgaatgcgg cgtccggtgg cagccgggcg
    22261 ccgccctctg tgtgaggcga cgcagtgccg ttcgacggtt cgagcatcct cccggcggac
    22321 agctagcaca agagtgggca attcactgtc gggtacctga caagcagatg catcgcatcg
    22381 agaaaatttc ggtgccatct cttgccaaat gcaattttcc gtgaaccagt tcaaccgagc
    22441 gtgactgcgc caaagcgcat ggtgagcagt catgttgtcg ggcgcatcgg cctatgagac
    22501 gaggaaaccg gtggaggggc gggtcaggac gccggtcatc gggaagcggg tggagccgtt
    22561 ccaccagtgc cacaccacgc gctcgctgcc gtcggcggcg gcgaagacgt ccatcccgcc
    22621 ggggccctgg tggttgccgg gaaggccccg gatcgggttg agtccggcgc tgccggtgta
    22681 gccgaagaag ggtcgggaca cgccctcgcg gatgggggtg cagcgggagc cgggcagggg
    22741 agtggcgccg cagcgggcga tgccggtggc gtagcgtgcg ctgtcccagt tgttgcccga
    22801 gtacatgagg taccagtccc cgtcggcggc cttccacatc gacgggttct ccaccacgtg
    22861 cgtaccgccg ctggtcttgg cggtgtccca ggtgatgtcg gtgctcttga gcatgtcccg
    22921 gcgggtgtcc cagatcgcgc ggccctcgcc gtcggtgcgg acggtggaga tgccggtctc
    22981 ggcgccggag gcgatggcgt cgtcccggta ggtgacgtac aggttcccgc cggccacgaa
    23041 ggggttggcg tcgagtgccc accggccggc gtccgggcac gcccattcgc cctggttctg
    23101 gaaggggccg cgggcgctgt cggagatcgc tcgtccgatg cacttctgcc cggtgccctt
    23161 gcgggaggcg gtgtagaaca tgaagaaccg gctgccgaag cgcgcgacgc ccggtgccca
    23221 gaccgcgccg ccgggctcgg cccaggcacc cggaccggac ggcagggcgt cgtgcgacgc
    23281 gcagtcggcc atgccgacgc tgttgccgga accgtggacg aggaccggta cgtacagcct
    23341 gccggtcgcg ccgcagcgcg caccggtccc ggcgccgacc gtggtgccgt aggtgacgta
    23401 cgagccgtcc ttggccagca gggtgtccgg gtcggccagc gggaaggtgg acgagtcggc
    23461 cagcgtggac aggtcgccgg cgggcgcggc ggcggcgggt gccaccgccg ccgtggtgac
    23521 caccagggcg gccgcggcga gggtgacgag ccctccgcgc gttcgaagga atttcaccgg
    23581 cactccttga ttgatgaagg taattatcag ggaaacggta tcgacggtca gcaatgccgt
    23641 caacggggga gtgctggggc tgagagcggg aagcggggcc gcccggagac ctgccgcgtt
    23701 acgctccgtc aaggggacgt gtcacccgcc gggccctcag gccggtgcca ggacccgtcg
    23761 gtaccctggc aggtcctggc ctgtccgcga cgacatgagg tattcgtgaa cgatcttcga
    23821 gtggtggcgt tcgatctcga cgacaccctg gcgatttcca agtcccagat cgatcgtcgg
    23881 atggcggagt tgctcggcca cctgctcacc gaggtggacg tgctggtcat ctccggtggc
    23941 cggttcgagc agttccagtc gcaggtgctc gcccacctcg acctcaccga ggagcagcgc
    24001 gaccggctgc acctgatgcc gacctgcggc acccgctact accgctggtc cgacggggac
    24061 tggcggcagg tctacgcgga ggatctgacc gaggccgaca aggcccgtgt cgtcgccgcg
    24121 ctcaccgagt cggcgcaggc gctgggtctg tgggaggcga agacctgggg cgacatcatc
    24181 gaggaccggg gcagccagat cacgttctcc gcgctggggc agtccgcccc gccggccgag
    24241 aagtacggct gggatccgga cggcgacaag aagcggcggc tgcgggacgc ggtcgcggcg
    24301 aagctgcccg acctggaggt gcgtggcggc ggctcgacct cgatcgacgt cacccgcaag
    24361 ggcgtggaca aggcgtacgg catgcggaag ctgctggaac acctggacct gaagatcgac
    24421 aacgtgctct tcgtgggtga ccgcctggac gtgggtggca acgactaccc ggtcaaggcg
    24481 atgggcatcc gctgcgtcgc ggtcacccgc tgggaggaga ccgccgacta cgtcgagaag
    24541 ctcgtcgacg acctggtgca gcagcgcgcc gagcgcgcct gagcgcagcc cgcagcagag
    24601 cccgccggtt ccggaaccgg cgggctctgg cggtatcgac ggtgatgagg taggaacagc
    24661 cgagagagcg ctctcccgtc ccatcaccga acaggcaggc agatgcgatc acccgacccc
    24721 tcccgccgcc gtttcctcac
//
