GCF_020428325.2 - 5 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP109812.1 (Stenotrophomonas sp. SBJS02)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	RiPP-like	1,204,565	1,215,410
Region 2	RiPP-like	1,569,491	1,580,366
Region 3	lanthipeptide-class-ii	1,791,341	1,814,238
Region 4	terpene-precursor	3,457,455	3,478,333
Region 5	arylpolyene	4,646,468	4,690,070	Low	aryl polyenes	other:other

NZ_CP109812.1 - Region 1 - RiPP-like

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Location: 1,204,565 - 1,215,410 nt. (total: 10,846 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000043.5	0.37	PKS	curacin A	Moorea producens 19L
BGC0000527.5	0.27	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0002575.2	0.27	ribosomal	cochonodin I	Streptococcus suis
BGC0000515.4	0.26	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0001727.3	0.25	ribosomal	paenilan	Paenibacillus polymyxa E681
BGC0001789.3	0.25	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000536.3	0.24	ribosomal	nisin Q	Lactococcus lactis
BGC0000535.4	0.24	ribosomal	nisin A	Lactococcus lactis subsp. lactis
BGC0000537.3	0.24	ribosomal	nisin U	Streptococcus uberis
BGC0000188.5	0.24	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000043.5	0.37	PKS	curacin A	Moorea producens 19L
BGC0000527.5	0.27	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0002575.2	0.27	ribosomal	cochonodin I	Streptococcus suis
BGC0000515.4	0.26	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0001727.3	0.25	ribosomal	paenilan	Paenibacillus polymyxa E681
BGC0001789.3	0.25	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000536.3	0.24	ribosomal	nisin Q	Lactococcus lactis
BGC0000535.4	0.24	ribosomal	nisin A	Lactococcus lactis subsp. lactis
BGC0000537.3	0.24	ribosomal	nisin U	Streptococcus uberis
BGC0000188.5	0.24	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

Additional weak hits (1):

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.64 out of 32.93

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator

NZ_CP109812.1 - Region 2 - RiPP-like

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Location: 1,569,491 - 1,580,366 nt. (total: 10,876 nt) Show pHMM detection rules used

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001962.3	0.27	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0000188.5	0.23	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0001650.4	0.23	NRPS	Le-pyrrolopyrazines	Lysobacter enzymogenes
BGC0000452.5	0.21	NRPS	tyrocidine	Brevibacillus brevis NBRC 100599
BGC0000651.5	0.20	terpene	KS-505a	Streptomyces argenteolus
BGC0001283.3	0.18	PKS	Bisenarsan	Streptomyces lividans 1326

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001962.3	0.27	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0000188.5	0.23	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0001650.4	0.23	NRPS	Le-pyrrolopyrazines	Lysobacter enzymogenes
BGC0000452.5	0.21	NRPS	tyrocidine	Brevibacillus brevis NBRC 100599
BGC0000651.5	0.20	terpene	KS-505a	Streptomyces argenteolus
BGC0001283.3	0.18	PKS	Bisenarsan	Streptomyces lividans 1326

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.19 out of 19.26

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.64 out of 26.85

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.74 out of 20.47

Confidence: medium

Additional weak hits (4):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.29 out of 39.62

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.00 out of 18.57

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.95 out of 30.25

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
RutR	Regulator of the pyrimidine and purine metabolism
VqsM	Regulator of quorum-sensing signalling systems

NZ_CP109812.1 - Region 3 - lanthipeptide-class-ii

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Location: 1,791,341 - 1,814,238 nt. (total: 22,898 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

FQS62_RS08600: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000528.5	0.52	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002703.2	0.49	ribosomal	archalan α	Halorussus salinus
BGC0000554.4	0.48	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002346.3	0.47	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0000503.5	0.46	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0001579.4	0.46	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0002698.2	0.43	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001576.3	0.43	ribosomal	divamide A	Prochloron didemni
BGC0000500.5	0.41	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0002316.2	0.41	ribosomal	cebulantin	Saccharopolyspora cebuensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000528.5	0.52	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002703.2	0.49	ribosomal	archalan α	Halorussus salinus
BGC0000554.4	0.48	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002346.3	0.47	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0000503.5	0.46	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0001579.4	0.46	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0002698.2	0.43	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001576.3	0.43	ribosomal	divamide A	Prochloron didemni
BGC0000500.5	0.41	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0002316.2	0.41	ribosomal	cebulantin	Saccharopolyspora cebuensis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for FQS62_RS08600

FQS62_RS08595

Leader:

MDLNDDVVSGWLNGSDDVDGCANPAGSLFIYGA

Core:

AATESALTSASDTLITGGGTECTTTMSVVNHCLCC

Core with dehydrations:

AADhbEDhaALDhbDhaADhaDDhbLIDhbGGGDhbECysDhbDhbDhbMDhaVVNHCysLCysCys

antiSMASH-DB 4.0 matches for FQS62_RS08595

100.0%

NZ_CP015612.1and 17 others:

NZ_CP027562.1 Lanthipeptides: C6Y55_RS08375_lanthipeptideNZ_CP028358.1 Lanthipeptides: C9J74_RS08630_lanthipeptideNZ_CP040435.1 Lanthipeptides: FEO92_RS08800_lanthipeptideNZ_CP040438.1 Lanthipeptides: FEO89_RS08350_lanthipeptideNZ_CP040439.1 Lanthipeptides: FEO88_RS08780_lanthipeptideNZ_CP056088.1 Lanthipeptides: HUZ96_RS08220_lanthipeptideNZ_CP090418.1 Lanthipeptides: LYZ64_RS08310_lanthipeptideNZ_CP109812.1 Lanthipeptides: FQS62_RS08595_lanthipeptideNZ_DS999412.1 Lanthipeptides: SSKA14_RS15505_lanthipeptideNZ_JAEDUZ010000008.1 Lanthipeptides: JAK52_RS03215_lanthipeptideNZ_JAEDWK010000010.1 Lanthipeptides: JAK51_RS04155_lanthipeptideNZ_JAJNMF010000022.1 Lanthipeptides: LQ423_RS11465_lanthipeptideNZ_JVUI01000059.1 Lanthipeptides: ADG58_RS15825_lanthipeptideNZ_LR134301.1 Lanthipeptides: EL200_RS07985_lanthipeptideNZ_OBEE01000002.1 Lanthipeptides: CRO53_RS02030_lanthipeptideNZ_RHQE01000015.1 Lanthipeptides: EGJ89_RS13150_lanthipeptideNZ_SOCO01000001.1 Lanthipeptides: N440_RS05690_lanthipeptide

Lanthipeptides: A7326_RS08120_lanthipeptide

AATESALTSASDTLITGGGTECTTTMSVVNHCLCC

97.1%

NZ_CP011010.1:

Lanthipeptides: VN11_RS08230_lanthipeptide

AATESALTSASDTLITGGGTECTTTMSVVNHCLCC

AATESALT+ASDTLITGGGTECTTTMSVVNHCLCC

AATESALTAASDTLITGGGTECTTTMSVVNHCLCC

97.1%

NZ_CP043578.1and 3 others:

NZ_CP067993.1 Lanthipeptides: JJL50_RS07700_lanthipeptideNZ_JVHP01000063.1 Lanthipeptides: ADI44_RS21105_lanthipeptideNZ_OU943334.1 Lanthipeptides: LNN95_RS09005_lanthipeptide

Lanthipeptides: F0Q13_RS08255_lanthipeptide

AATESALTSASDTLITGGGTECTTTMSVVNHCLCC

ATESALTSASDTLITGGGTECTTTMSVVNHCLCC

GATESALTSASDTLITGGGTECTTTMSVVNHCLCC

with 16 more sequence matches

Only the first 10 are displayed here.

72.3%

NZ_CP047310.1and 4 others:

NZ_CP104169.1 Lanthipeptides: NDR96_RS06465_lanthipeptideNZ_JABDRV010000001.1 Lanthipeptides: HRL60_RS01085_lanthipeptideNZ_JAEDVS010000025.1 Lanthipeptides: JAK50_RS15965_lanthipeptideNZ_JVPM01000038.1 Lanthipeptides: ADH50_RS19075_lanthipeptide

Lanthipeptides: GS396_RS07720_lanthipeptide

ATESALTSASDTLITGGGTECTTTMSVVNHCLCC

37.1%

NZ_CP011305.1and 19 others:

NZ_CP031058.1 Lanthipeptides: DUW70_RS15590_lanthipeptideNZ_CP031167.1 Lanthipeptides: MG068_RS07815_lanthipeptideNZ_CP040436.1 Lanthipeptides: FEO91_RS08085_lanthipeptideNZ_CP046588.1 Lanthipeptides: GOC52_RS08100_lanthipeptideNZ_CP060259.1 Lanthipeptides: H7F32_RS08235_lanthipeptideNZ_CP071784.1 Lanthipeptides: J3U96_RS13765_lanthipeptideNZ_CP077679.1 Lanthipeptides: KS456_RS07940_lanthipeptideNZ_CP096975.1 Lanthipeptides: M1L61_RS08375_lanthipeptideNZ_CP104071.1 Lanthipeptides: K7565_RS07800_lanthipeptideNZ_CP104287.1 Lanthipeptides: K7567_RS07875_lanthipeptideNZ_CP104324.1 Lanthipeptides: K7569_RS08320_lanthipeptideNZ_JACLBK010000002.1 Lanthipeptides: ID844_RS05155_lanthipeptideNZ_JAEDVP010000027.1 Lanthipeptides: JAK38_RS15550_lanthipeptideNZ_JAEDVW010000007.1 Lanthipeptides: JAK53_RS03160_lanthipeptideNZ_JAEDWD010000009.1 Lanthipeptides: JAK45_RS02000_lanthipeptideNZ_JAFLWT010000006.1 Lanthipeptides: J1F00_RS06425_lanthipeptideNZ_JAQQGI010000014.1 Lanthipeptides: PQS91_RS16925_lanthipeptideNZ_KB907502.1 Lanthipeptides: G370_RS0114170_lanthipeptideNZ_RHPZ01000014.1 Lanthipeptides: EGJ03_RS16365_lanthipeptide

Lanthipeptides: YH67_RS07965_lanthipeptide

ECTTTMSVVNHCLCC

ECTTT+SV+NHCLCC

ECTTTVSVINHCLCC

36.2%

NZ_CP007597.1:

Lanthipeptides: DX03_RS09815_lanthipeptide

ATESALTSASDTLITGGGTECTTTMSVVNHCLCC

AT++ALT+ + T++TGG CTTTMSV+NHC+CC

ATDAALTAMAPTMVTGGTGNCTTTMSVINHCMCC

29.3%

NZ_CP069396.1:

Lanthipeptides: JRI60_RS03735_lanthipeptide

AATESALTSASDTLIT

AATE+ALT ASD L+T

AATENALTDASDALVT

28.8%

NZ_CP069338.1:

Lanthipeptides: JQX13_RS07220_lanthipeptide

ATESALTSASDTLITGGGTECTTTMSVVNHCLCC

ATE+ALT+++D L T G + CT ++ H CC

ATEAALTNSTDALYT-GCSSCTGSL----HSYCC

26.4%

NZ_CP093340.1:

Lanthipeptides: MNO14_RS04685_lanthipeptide

AATESALTSASDTLITGGGTECTT-TMSVVNHC

AATE+A+T S L+ T+C++ T S+ HC

AATEAAMTDKSFLLL----TQCSSCTASIPAHC

24.4%

NZ_CP029194.1and 1 other:

NZ_CP059991.1 Lanthipeptides: H4W23_RS35675_lanthipeptide

Lanthipeptides: DEJ46_RS04155_lanthipeptide

AATESALTSASDTLITG

AA E+ALT A++ L+TG

AAGEAALTDATEALLTG

24.4%

NZ_JH941044.1:

Lanthipeptides: Y19_RS0126875_lanthipeptide

AATESALTSASDTLITG

AA E+ALT A++ L TG

AAGEAALTDATEALFTG

22.9%

NZ_CP089924.1:

Lanthipeptides: LVB77_RS02735_lanthipeptide

TGGGTECTTTMSVVNHC

+G CT+ SV NHC

SGASVNCTSGSSVSNHC

22.0%

NZ_CP010407.1and 4 others:

NZ_CP010407.1 Lanthipeptides: SVTN_RS37515_lanthipeptideNZ_CP010407.1 Lanthipeptides: SVTN_RS37515_lanthipeptideNZ_CP010407.1 Lanthipeptides: SVTN_RS37515_lanthipeptideNZ_JACHJY010000017.1 Lanthipeptides: GGE06_RS39715_lanthipeptide

Lanthipeptides: SVTN_RS37515_lanthipeptide

AATESALTSASDTLITG

AA E+ALT ++ L+TG

AAGEAALTDGTEALLTG

allorf_1794166_1794387

Leader:

MAPSMAPTVLERAACPLLTVSWCVRMRRSAGRLLPQLAGNRPESVGS

Core:

PRAGPLAPRMAPSSPHGWVHGVSCPG

Core with dehydrations:

PRAGPLAPRMAPDhaDhaPHGWVHGVDhaCysPG

antiSMASH-DB 4.0 matches for allorf_1794166_1794387

100.0%

NZ_CP046588.1and 6 others:

NZ_CP056088.1 Lanthipeptides: allorf_1820746_1820967_lanthipeptideNZ_CP060259.1 Lanthipeptides: allorf_1747353_1747574_lanthipeptideNZ_CP104071.1 Lanthipeptides: allorf_1665125_1665346_lanthipeptideNZ_CP109812.1 Lanthipeptides: allorf_1794166_1794387_lanthipeptideNZ_JVPM01000038.1 Lanthipeptides: allorf_457583_457804_lanthipeptideNZ_OU943334.1 Lanthipeptides: allorf_1870884_1871105_lanthipeptide

Lanthipeptides: allorf_1742372_1742593_lanthipeptide

PRAGPLAPRMAPSSPHGWVHGVSCPG

96.2%

NZ_CP040435.1:

Lanthipeptides: allorf_1850191_1850412_lanthipeptide

PRAGPLAPRMAPSSPHGWVHGVSCPG

PRAGPLAPRMA SSPHGWVHGVSCPG

PRAGPLAPRMASSSPHGWVHGVSCPG

96.2%

NZ_RHPZ01000014.1:

Lanthipeptides: allorf_009576_009797_lanthipeptide

PRAGPLAPRMAPSSPHGWVHGVSCPG

PRAGPLAP MAPSSPHGWVHGVSCPG

PRAGPLAPWMAPSSPHGWVHGVSCPG

with 5 more sequence matches

84.6%

NZ_SOCO01000001.1:

Lanthipeptides: allorf_1178234_1178455_lanthipeptide

GPLAPRMAPSSPHGWVHGVSCPG

GPLAP MAPSSPHGWVHGVSCPG

GPLAPWMAPSSPHGWVHGVSCPG

34.6%

NZ_CP101417.1:

Lanthipeptides: allorf_0369305_0369400_lanthipeptide

MAPSSPHGWVHGVSC

M P S HG GVSC

MPPPSLHGRTCGVSC

30.8%

NZ_JABDRV010000001.1:

Lanthipeptides: allorf_0223350_0223580_lanthipeptide

APSSPHGWVHGVSCPG

18.8%

NZ_AZVD01000036.1and 1 other:

NZ_KB913036.1 Lanthipeptides: A39M_RS1000000128680_lanthipeptide

Lanthipeptides: K389_RS1000000128010_lanthipeptide

PRAGPLAPRMAPSSPHGWVHGV

PR+GPLA A S + G+

PRSGPLATECADSVVATALDGL

17.5%

NZ_PUPX01000001.1:

Lanthipeptides: allorf_1103640_1103849_lanthipeptide

SPHGWVHGVS

S HG +HGVS

SLHGRIHGVS

allorf_1800751_1800891

Leader:

MPAPAGHPMSLRLPSIRSRMNGA

Core:

RPRIPCRLRAAHAAHPRACRSAA

Core with dehydrations:

RPRIPCysRLRAAHAAHPRACysRDhaAA

antiSMASH-DB 4.0 matches for allorf_1800751_1800891

100.0%

NZ_CP028358.1and 5 others:

NZ_CP040435.1 Lanthipeptides: allorf_1856776_1856916_lanthipeptideNZ_CP056088.1 Lanthipeptides: allorf_1814243_1814383_lanthipeptideNZ_CP109812.1 Lanthipeptides: allorf_1800751_1800891_lanthipeptideNZ_JAEDUZ010000008.1 Lanthipeptides: allorf_126406_126546_lanthipeptideNZ_LR134301.1 Lanthipeptides: allorf_1747066_1747206_lanthipeptide

Lanthipeptides: allorf_1803368_1803508_lanthipeptide

RPRIPCRLRAAHAAHPRACRSAA

87.0%

NZ_CP047310.1:

Lanthipeptides: allorf_1658784_1658924_lanthipeptide

RPRIPCRLRAAHAAHPRACRSAA

RPRIP R RAAHAA PRACRSAA

RPRIPSRFRAAHAALPRACRSAA

78.3%

NZ_CP011305.1and 4 others:

NZ_CP046588.1 Lanthipeptides: allorf_1748975_1749091_lanthipeptideNZ_CP096975.1 Lanthipeptides: allorf_1778660_1778776_lanthipeptideNZ_JAEDVP010000027.1 Lanthipeptides: allorf_23874_23990_lanthipeptideNZ_RHPZ01000014.1 Lanthipeptides: allorf_016179_016295_lanthipeptide

Lanthipeptides: allorf_1722617_1722733_lanthipeptide

RPRIPCRLRAAHAAHPRACRSAA

RP IP RAAHAA PRACRSAA

RPLIPSCFRAAHAALPRACRSAA

with 4 more sequence matches

39.1%

NZ_OBEE01000002.1and 1 other:

NZ_RHQE01000015.1 Lanthipeptides: allorf_094530_094610_lanthipeptide

Lanthipeptides: allorf_016795_016875_lanthipeptide

HPRACRSAA

30.4%

NZ_LMEQ01000012.1:

Lanthipeptides: allorf_0970902_0971075_lanthipeptide

RIPCRLRAAHAAHPRACRSA

R+PC + + A + RSA

RVPCSVGGSGAYTADSARSA

20.0%

NZ_CP095742.1:

Lanthipeptides: allorf_0682536_0682703_lanthipeptide

RPRIPCRLRAAHAAHPRA

RP I C+ RA A P A

RPSIRCKGRAMVTAQPAA

12.5%

NZ_JALBFU010000003.1:

Lanthipeptides: MD221_RS10145_lanthipeptide

RPRIPC--RLRAAHAAHPRA

RP IPC L+ A P +

RPTIPCTPELQGTIVATPTS

allorf_1809036_1809203

Leader:

MVVRLDCGGWPGGWAVQGA

Core:

LQVRPCKLGRRIHAAHVPAQPIRPATDRFRARPPRN

Core with dehydrations:

LQVRPCysKLGRRIHAAHVPAQPIRPADhbDRFRARPPRN

antiSMASH-DB 4.0 matches for allorf_1809036_1809203

100.0%

NZ_CP109812.1and 1 other:

NZ_JAEDUZ010000008.1 Lanthipeptides: allorf_118094_118261_lanthipeptide

Lanthipeptides: allorf_1809036_1809203_lanthipeptide

LQVRPCKLGRRIHAAHVPAQPIRPATDRFRARPPRN

97.2%

NZ_CP056088.1:

Lanthipeptides: allorf_1805931_1806098_lanthipeptide

LQVRPCKLGRRIHAAHVPAQPIRPATDRFRARPPRN

LQVRPCKLGRRIHAAH PAQPIRPATDRFRARPPRN

LQVRPCKLGRRIHAAHAPAQPIRPATDRFRARPPRN

94.4%

NZ_CP028358.1:

Lanthipeptides: allorf_1811653_1811820_lanthipeptide

LQVRPCKLGRRIHAAHVPAQPIRPATDRFRARPPRN

LQVRPCKLGRRIHAAH PAQPIRPATDRFRAR PRN

LQVRPCKLGRRIHAAHAPAQPIRPATDRFRARRPRN

with 7 more sequence matches

31.4%

NZ_JAEDVW010000007.1:

Lanthipeptides: allorf_07444_07683_lanthipeptide

HVPAQPIRPATDRFRARPPRN

+ PAQ +R ATDRFRARPPRN

YAPAQSLRRATDRFRARPPRN

25.6%

NZ_PUPX01000001.1:

Lanthipeptides: allorf_1091992_1092165_lanthipeptide

QVRPCKLGRRIHAAHVPAQPIRPATDRF

Q +PC LGR + IRPA D+

QTQPCTLGRLLITVGRIKLIIRPAGDQL

22.2%

NZ_CP022961.1:

Lanthipeptides: allorf_3789711_3789887_lanthipeptide

VPAQPIRPATDRFRA

+ A P+RPA FRA

IHACPVRPALATFRA

21.8%

NZ_FNIE01000004.1:

Lanthipeptides: allorf_379559_379762_lanthipeptide

AAHVPAQPIRPATDRFRARPP

AA PA R T RFR RPP

AAVAPAVGRRGLTRRFRYRPP

17.9%

NZ_CP019687.1and 1 other:

NZ_CP019717.1 Lanthipeptides: ERICV_RS20670_lanthipeptide

Lanthipeptides: BXP28_RS22835_lanthipeptide

RPCKLGRRIHAA

RP LGR +H A

RPTVLGRDLHEA

16.7%

NZ_CP095462.1:

Lassopeptides: MUG87_RS00750_lassopeptide

LGRRIHAAHVPAQPIRP

G A+VP +P+ P

YGPYTDEAYVPGKPVDP

11.6%

NZ_BORO01000007.1:

Lanthipeptides: allorf_084681_084911_lanthipeptide

LQVRPCKLGRR

+ +RPC LG++

IDIRPCFLGQK

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 27.95 out of 32.74

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.47 out of 28.19

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.67 out of 24.78

Confidence: medium

Additional weak hits (5):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.61 out of 29.38

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.90 out of 30.22

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.79 out of 29.65

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.77 out of 23.43

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.18 out of 29.65

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

FQS62_RS08595 - Class II

Cleavage pHMM score: -6.70

RODEO score: 0

Monoisotopic mass: 3231.5 Da

Molecular weight: 3233.6 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3251.6 Da N = 1; 3269.6 Da N = 2; 3287.7 Da N = 3; 3305.7 Da N = 4; 3323.7 Da N = 5; 3341.7 Da N = 6; 3359.7 Da N = 7; 3377.8 Da N = 8

allorf_1794166_1794387 - Class II

Cleavage pHMM score: -5.70

RODEO score: 0

Monoisotopic mass: 2566.3 Da

Molecular weight: 2567.9 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2586.0 Da N = 1; 2604.0 Da N = 2

allorf_1800751_1800891 - Class II

Cleavage pHMM score: -1.60

RODEO score: 0

Monoisotopic mass: 2518.4 Da

Molecular weight: 2520.0 Da

Number of bridges: 1

allorf_1809036_1809203 - Class II

Cleavage pHMM score: -4.70

RODEO score: 0

Monoisotopic mass: 4132.3 Da

Molecular weight: 4134.8 Da

Number of bridges: 1

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
FuR variant 2	Ferric Uptake Regulator
LexA variant 2	Repressor of DNA damage response
ZuR variant 1	Zinc-responsive repressor

NZ_CP109812.1 - Region 4 - terpene-precursor

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Location: 3,457,455 - 3,478,333 nt. (total: 20,879 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthetase

FQS62_RS16120: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000643.3	0.33	terpene	carotenoid	Brevundimonas vesicularis
BGC0000634.3	0.32	terpene	carotenoid	Brevundimonas sp. SD212
BGC0000640.3	0.32	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000630.3	0.31	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0002219.2	0.31	terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0000641.3	0.30	terpene	carotenoid	Enterobacteriaceae bacterium DC416
BGC0000639.3	0.30	terpene	carotenoid	Enterobacteriaceae bacterium DC260

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000643.3	0.33	terpene	carotenoid	Brevundimonas vesicularis
BGC0000634.3	0.32	terpene	carotenoid	Brevundimonas sp. SD212
BGC0000640.3	0.32	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000630.3	0.31	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0002219.2	0.31	terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0000641.3	0.30	terpene	carotenoid	Enterobacteriaceae bacterium DC416
BGC0000639.3	0.30	terpene	carotenoid	Enterobacteriaceae bacterium DC260

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

FQS62_RS16120: PT_FPPS_like

Domain 1 (32 - 292): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.13 out of 19.26

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 19.52 out of 19.52

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.86 out of 18.57

Confidence: medium

Additional weak hits (1):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.89 out of 26.06

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
CRP	Cyclic AMP receptor protein
ToxT	Regulator of MSHA biosynthesis

NZ_CP109812.1 - Region 5 - arylpolyene

Download region GenBank file

Download region SVG

Location: 4,646,468 - 4,690,070 nt. (total: 43,603 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

FQS62_RS21450: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

FQS62_RS21495: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acyltransferase

FQS62_RS21565: acyltransferase

smcogs: SMCOG1141: acyltransferase

Hydrolases: hydrolase

FQS62_RS21455: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Ligases: ligase synthase

FQS62_RS21490: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

FQS62_RS21505: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

FQS62_RS21540: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

FQS62_RS21545: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000837.4	0.64	other (other)	APE Vf	Aliivibrio fischeri ES114
BGC0002008.3	0.63	other (other)	aryl polyenes	Xenorhabdus doucetiae
BGC0000836.5	0.62	other (other)	APE Ec	Escherichia coli CFT073
BGC0002276.2	0.60	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001164.3	0.59	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002000.4	0.49	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0001723.5	0.49	PKS	oviedomycin	Streptomyces antibioticus
BGC0001895.4	0.49	PKS	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0002047.2	0.49	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0002510.2	0.48	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000837.4	0.64	other (other)	APE Vf	Aliivibrio fischeri ES114
BGC0002008.3	0.63	other (other)	aryl polyenes	Xenorhabdus doucetiae
BGC0000836.5	0.62	other (other)	APE Ec	Escherichia coli CFT073
BGC0002276.2	0.60	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001164.3	0.59	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002000.4	0.49	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0001723.5	0.49	PKS	oviedomycin	Streptomyces antibioticus
BGC0001895.4	0.49	PKS	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0002047.2	0.49	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0002510.2	0.48	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces sp.

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.99 out of 20.47

Confidence: medium

Additional weak hits (4):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.18 out of 26.06

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.50 out of 21.55

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 18.63 out of 33.14

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

TFBS Finder

NRPS/PKS substrate predictions

FQS62_RS21545: X

AMP-binding (124..344): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: THQ-----LFRWVAFSSGGTEVYGSSETGGIAWR
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
VqsM	Regulator of quorum-sensing signalling systems