LOCUS       NZ_CP084541            17422 bp    DNA     linear   CON 20-NOV-2024
DEFINITION  Streptomyces marincola strain SCSIO 64649 chromosome, complete
            genome.
ACCESSION   NZ_CP084541
VERSION     NZ_CP084541.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces marincola
  ORGANISM  Streptomyces marincola
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 6629020)
  AUTHORS   Shi,S.
  TITLE     Strepomyces indimicinicus sp. nov., an antibiotic producing
            actinomycetes isolated from the marine environment
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6629020)
  AUTHORS   Shi,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2021) Key Laboratory of Tropical Marine
            Bio-resources and Ecology, South China Sea Institute of Oceanology,
            Chinese Academy of Sciences, 164 Xingang West Road, guangzhou,
            Guangdong 510301, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. V6.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 444.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_020410765.1-RS_2024_11_18
            Annotation Date                   :: 11/18/2024 03:45:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,763
            CDSs (total)                      :: 5,689
            Genes (coding)                    :: 5,612
            CDSs (with protein)               :: 5,612
            Genes (RNA)                       :: 74
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 77
            CDSs (without protein)            :: 77
            Pseudo Genes (ambiguous residues) :: 0 of 77
            Pseudo Genes (frameshifted)       :: 21 of 77
            Pseudo Genes (incomplete)         :: 60 of 77
            Pseudo Genes (internal stop)      :: 2 of 77
            Pseudo Genes (multiple problems)  :: 6 of 77
            CRISPR Arrays                     :: 10
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:57:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6611598
            Orig. end                         :: 6629020
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP084541.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..17422
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene"
                     /region_number="36"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..17422
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..17422
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[10000:11947](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11947
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            518..1225
                     /locus_tag="LC193_RS28795"
                     /old_locus_tag="LC193_28795"
     CDS             518..1225
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF033580.1"
                     /locus_tag="LC193_RS28795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_28795"
                     /product="IS5 family transposase"
                     /protein_id="WP_264086287.1"
                     /transl_table=11
                     /translation="MDAIRYIVDNGAKWRALPADFPPWETVYAVFARWNRAGVVAWIRD
                     QLRRRIRTGAGRCPYPVTLIVDSQSVKGAFTVGQASRGYDAGKKINGRKRHIAVDTLGL
                     PEMITVTPAEHDRPGSRPRTPLAPSPHSPPQLTQVWADSAYVGQLVTWAGERRCLALRT
                     VSRPRGTKGFVVLPRRWRVERTIGWLMNARGNVRDYERLPQHSEAHLTWALITLMTRRL
                     TRKGTRPNWSKKP"
     gene            complement(1294..1851)
                     /locus_tag="LC193_RS29260"
                     /old_locus_tag="LC193_28800"
     CDS             complement(1294..1851)
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012521.5"
                     /locus_tag="LC193_RS29260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_28800"
                     /product="histidine phosphatase family protein"
                     /protein_id="WP_226078388.1"
                     /transl_table=11
                     /translation="MQWLEVRRHAPTKKGAARGRGSHLSAHGVALARAVGVGLGPFAHV
                     VTSASPRAIETAVALGWAVDDTVVLPSGYVAGEIEHHDQWAWPRPYVRYAELIANGGGL
                     AAVAAEHRRIWTEVVRSVPDGNGALIVSHGGSIEPTLVSCLPDADHSLWGKAFGHLDGV
                     RLDFEDGRFTRAHLHRAPSTRA"
     misc_feature    complement(1840..1842)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(1954..2544)
                     /locus_tag="LC193_RS28805"
                     /old_locus_tag="LC193_28805"
     CDS             complement(1954..2544)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003995835.1"
                     /locus_tag="LC193_RS28805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_28805"
                     /product="phosphotransferase"
                     /protein_id="WP_226078390.1"
                     /sec_met_domain="APH (E-value: 3.3e-12, bitscore: 45.2,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSYLDGESGPQGWARVVDDAGLVAFARFLRGDHDAVAGFRLPEG
                     LSWCTGESRPGEGEVVCHGDFGPWNIVWRGAAPVGILDWDYARPARRLYNVAYALEYVA
                     PFRDDDECLRWLQYSEPPDRRHRLELFATAYGLTSTTGLVDAVIDVQQDTIEQVRRLAE
                     RGNQPHVHWVAEGHLDELGQRVAWSRANRHLVE"
     misc_feature    complement(2701..2717)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 19.35"
                     /tool="antismash"
     gene            complement(2850..4286)
                     /locus_tag="LC193_RS28810"
                     /old_locus_tag="LC193_28810"
     CDS             complement(2850..4286)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014176311.1"
                     /locus_tag="LC193_RS28810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_28810"
                     /product="NF041680 family putative transposase"
                     /protein_id="WP_226078392.1"
                     /transl_table=11
                     /translation="MSLLPQTVPGDAFAEASRFRDELYACLTVRGDELFELADAVLCAP
                     GAVHSAVELTLLPEHRRGHGAMYDGLNQGRIDTDRLRSVLAGLPLPRFPDGRLVLAVDV
                     SPWLRSDAPCSPERLFCHVYGRAKTASQFIPGWPYSFVAVLEMGATSWAQILDAVRLGP
                     VGDATAVTATQLRDVVDRLITAGQWQPGEPDILVVTDAGYDVTRLAWVLRDLPVELVGR
                     VRGDRVMRLPKPPRLPGTNGRPPKHGPEFRFAKPETWPEPAVTTRTATANYGKAVTQAW
                     DRVHPRLTHRAAWLDHVGVLPLIEGTLIRLEVKHLSKGREAPAVWLWSSKTGATDADID
                     RAWQAFLRRFDLEHTFRLFKQTLGWTKPRLREPEAADRWTWLIIAAYTQLRLARPLAQD
                     LRHPWEKPAAHGRLTPARVRRTFRNLRQHMPCPARAPKPHRPGPGRPPGTRNRRLAPRC
                     DVGKTVRREKTLIALQRLKG"
     misc_feature    complement(3594..3596)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(4515..4763)
                     /locus_tag="LC193_RS28815"
                     /old_locus_tag="LC193_28815"
     CDS             complement(4515..4763)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LC193_RS28815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LC193_28815"
                     /product="hypothetical protein"
                     /protein_id="WP_226078399.1"
                     /transl_table=11
                     /translation="MSRRYRLQYNDQARDALRKMSSQRRRLFEAAVADIAAAPYVHGQA
                     LDENRDRRQAPVAGAVTVYWVSSGVLTVFVVRITHTD"
     misc_feature    complement(4764..4775)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     gene            complement(5098..5955)
                     /locus_tag="LC193_RS28820"
                     /old_locus_tag="LC193_28820"
     CDS             complement(5098..5955)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020139584.1"
                     /locus_tag="LC193_RS28820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_28820"
                     /product="hypothetical protein"
                     /protein_id="WP_226078401.1"
                     /transl_table=11
                     /translation="MQKTALIPYARLPRAHHGRHIVTSTVDVFGGAHWLLAERAPQPGG
                     DVPLVDALVVSVHPDGNVELTELSAVRASGSYLGRLPDGRFLVATSRARGHEDRDQVQI
                     FDALGRQAASFFVGDAIEHLLTDEAGHIWVGHFDENPAGIRRWNATGQLTWTWDGARIP
                     GLVDCYALNVSGTSAWACTYTDFPLVEIRPDQRVTVWTNRIRGARAVAVHRHRVAFYGG
                     YGEERNRLAHGELSETSVQPTDVGLLTLPNGDAPGRRRVAARGSRIYVQAEPFTTWSVF
                     DLNS"
     misc_feature    6109..6123
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 20.16"
                     /tool="antismash"
     gene            6286..6903
                     /locus_tag="LC193_RS28825"
                     /old_locus_tag="LC193_28825"
     CDS             6286..6903
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016325585.1"
                     /locus_tag="LC193_RS28825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_28825"
                     /product="hypothetical protein"
                     /protein_id="WP_226078403.1"
                     /transl_table=11
                     /translation="MARPQEVVSGLLPEVLRAEVAPESCPAWLLRPGRAECVQMWETVA
                     AVYRALTGLVLPEQAPPRERRRLDAVLRYADGRQQILEIDERQHFTGARATTLECYPAD
                     AALGFDARVWLARSRTLAGREPAGGFAAPRPPLFPGAGGRHRQRAFRDTLADLLPPAHG
                     WLPTLRISDIEVTAVAAAADPAAALRLLLAARGVPQSRLLPG"
     gene            complement(7174..7851)
                     /locus_tag="LC193_RS28830"
                     /old_locus_tag="LC193_28830"
     CDS             complement(7174..7851)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LC193_RS28830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LC193_28830"
                     /product="hypothetical protein"
                     /protein_id="WP_226078405.1"
                     /transl_table=11
                     /translation="MVERLNDDGRAGIDAALVKHDEEDQEAADNDDAGRPRPAAVPLLR
                     FSRPRDPAAIARFLRGHVPANSGAAPTPANMPKRRTRPLSPAQMAQSYGLELGLDHRHQ
                     PRGGRPRQRGGRPRPGGPSFQVFVFDMVLATLHWYRRPEAWALAQAWRQVVTDQEEFLA
                     WVAVVGLRRPEAVRELRYHRFTPDVLEAARVGGVPVRSRLRNGKDIEHVIAALYRSAAR
                     PST"
     gene            complement(7936..8550)
                     /locus_tag="LC193_RS28835"
                     /old_locus_tag="LC193_28835"
     CDS             complement(7936..8550)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LC193_RS28835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LC193_28835"
                     /product="hypothetical protein"
                     /protein_id="WP_226078407.1"
                     /transl_table=11
                     /translation="MAVLCGCGGEGEPPTDGVPAVPTSPKPREIPMPPGPPETRDGYDA
                     CGGDPFDAGAVVAYSPDGPAWSGPGPHPAVLFRPGSLPEVEVPQLPQEWSGSAPYDFTQ
                     LVVCEYSDDEFEGEKVGDCSYLGGAPYGDRDPEVFSERYIYRVFEAKTGEQVAEFSLDG
                     TTSPDESCPETSYAPPSTYWQRVESDALEEELRPLVEGSAP"
     gene            complement(8791..9592)
                     /locus_tag="LC193_RS28840"
                     /old_locus_tag="LC193_28840"
                     /pseudo=""
     CDS             complement(8791..9592)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006374174.1"
                     /locus_tag="LC193_RS28840"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_28840"
                     /product="SAM-dependent methyltransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSESASRPIDTSVPHSARIWNYLLGGKDYYEVDRVAGEAYREAFP
                     GIVDIARGQRYFLGRAVRFLAGEAGIRQFLDIGTGLPTQDNTHELAQRVAPEAHIVYVD
                     NDPLVLAHAGALLTSSPEGRTYYVEADVRDPDAILAAAAERLDFSRPVALTMLGVLGHI
                     GDEERPHAIVRRLVEGLPAGSYVALADGTDTNLEFAEAQRRYNEGGAVPYTLRSPGQMV
                     AFFDGLELVEPGVVPLPAVASSVCRGGGGDGYHTRAVRDWPEARV"
     misc_feature    complement(9524..9526)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            10001..11947
                     /gene="shc"
                     /locus_tag="LC193_RS28845"
                     /old_locus_tag="LC193_28845"
     CDS             10001..11947
                     /EC_number="5.4.99.17"
                     /GO_function="GO:0016866 - intramolecular transferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0051007 - squalene-hopene cyclase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019746 - hopanoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="shc"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR01507.1"
                     /locus_tag="LC193_RS28845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_28845"
                     /product="squalene--hopene cyclase"
                     /protein_id="WP_226078409.1"
                     /sec_met_domain="T2TS (E-value: 1.5e-111, bitscore: 372.0,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDIHAHNTLARGIDNLLARQLDDGHWYEGPHTNVSAESADIIAR
                     HCLGITDTAALERTALRVRRGQHDDGSWPMFPGGPGHLSVTAEAYLALRLAGDPPDEPH
                     MRSAARFCRRHGGLGAARTETHFWLAVLGIRAWDRVPPILPEQILFPAGTPVAVRSLGV
                     WSRHLLTPLSVIAAQRPIWPAGFDLPELYDPTSPAETAPPGKAEQVMRAYHKHPLRPLR
                     GRALARAELWLLRNQQANGSWFHVFLFTALGTLALKALGYTTDNNAYRSALAALDSFGA
                     PLETPDGTARRIVPCPGPVWDTAYSLLALLDAGVEPTHPAIERACTWLIAQQSTSGGDW
                     QRDRPRVPPGGWPFSPGLNNYPDLDDTAIAITALTRLRDSNGQLPPAVAPAVERGQAWL
                     AGLQSRKGGWAAYESGDLSPLTELSQRLPYNDHGPMLDVPTADVTGHVLEALTAAAPEG
                     GARRPSAAAEWLLAQQEPDGSWFGRWGVNHIYGTGSAVPGLVAAGIGPGDPHIRRAADW
                     LRQHQNADGGWGEDCRSYDDPAHRGRGRSTPSQTAWALLALHAAGVGADDNQVRAAFTW
                     LADHQRPDGSWDEEVFTATGQPGEIYFAYPAIVQAMPVIALGRYLAPTQPPGQPDPPHP
                     RLTAEQESGHGTA"
     gene            11934..13058
                     /locus_tag="LC193_RS28850"
                     /old_locus_tag="LC193_28850"
     CDS             11934..13058
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013226.5"
                     /locus_tag="LC193_RS28850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_28850"
                     /product="UbiA family prenyltransferase"
                     /protein_id="WP_226078411.1"
                     /transl_table=11
                     /translation="MAPRDGETLSEAEPTHRQPAQNWTALPPHELVNLVRRSPGTAGPA
                     RTARLLIALSRPRTCTPSLTIYALGYGIVAGEVHWQFWLGAFLMLTTGMLANLYNVHTD
                     LDEDSVNMPGRLGLVGEIGWRRYRTTLAIWSAAVALSSIPLGPGPLGIFLLVLAGSHQY
                     SYRPLRLKAKPVAGLLGFALAGYGPLIFGYTVACTATGQADPPPNPDTLLWLLALITLW
                     LVAKGLVKNVPDYDGDKRTGLRTSATVFPTRRAAALAAGTATVGVHLAAPLFTFLAHGN
                     EGAGSLRWLLLVPAVPFAVLQAIRMTRAVGTHANSVLKQDMWFTFLFIALVLALSAPAA
                     ITAPALAATALLMVAVDALRVDSRENNLTRTTTG"
     gene            13222..14493
                     /locus_tag="LC193_RS28855"
                     /old_locus_tag="LC193_28855"
     CDS             13222..14493
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.5"
                     /locus_tag="LC193_RS28855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_28855"
                     /product="cytochrome P450"
                     /protein_id="WP_226078412.1"
                     /sec_met_domain="p450 (E-value: 3.5e-46, bitscore: 156.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAGMSHLHHTYGPVAALGIGPLRWTFLFGTDANELVLGNTENFE
                     FSYGGLQAIAGDTALVALPNAENRTMRQLLRPLFDREHVDAYADRVLDRVRDRLAAWPR
                     NTTVDAYTELRLAVRLASVDSFIGPGVLNREGNTLDTTLEQLHTVLNRSSILTLLVWNA
                     PRLGRLRLRKPLSRIDRVVHAEITRRRSGATPTPDPIDPIGFLLRPGIYPELPAGDHTV
                     RDTVVSLLIASYDPTSSALGWSLYGLLANPEVLAEAKREVARELGDEPVRAATARRLKY
                     LGHVVAEAIRVHPPVVASARHCVKGFEVHGHRIPAGSRLMLSQFTSHRSPDSWPDPERF
                     DPDRWDRTGTVTAAVPPAAYFPYGSPRRRCPGSGMAAVIVPAVLAAVLQAGDITLADNS
                     PPRLDGFAALRPKAGLPVRVHQSH"
     gene            14576..14986
                     /locus_tag="LC193_RS28860"
                     /old_locus_tag="LC193_28860"
     CDS             14576..14986
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017897.5"
                     /locus_tag="LC193_RS28860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_28860"
                     /product="Mpo1-like protein"
                     /protein_id="WP_226078413.1"
                     /transl_table=11
                     /translation="MTTINQPKPAVDNNTTAPRTAPLELSSFDRYLLAHTKASTRWGHV
                     VAMGAALATPATAPKGKRLRRTLLGVPVFFSIAWPSHFIFERNMPVGFTDSKAAFSGDL
                     RMIWMMVTGRNHELAERIEELQRLLADQAGDR"
     gene            14983..16614
                     /locus_tag="LC193_RS28865"
                     /old_locus_tag="LC193_28865"
     CDS             14983..16614
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042: O-methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013087.5"
                     /locus_tag="LC193_RS28865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_28865"
                     /product="DUF6875 domain-containing protein"
                     /protein_id="WP_226078414.1"
                     /transl_table=11
                     /translation="MTAEDVRRLIYGQIVSKAVQTFVLLGLPNLMRDAEHPLEQLTRSV
                     GANPTSLRRLLRALAAFRIVQETAHDTFALEPLGHQLRSDTPRTAHPTALLAANLVGQA
                     WDGMAHAVRTGKPAFEEITGTPFFSYLSDNPPLRSIFDASQAAGLHAELPGILTALGPT
                     PPRVAVDVGGGDGALLEHILTHHPGTRGVLLDRPESREPATARMKRAGLADRFTFHAGD
                     FLTDDVPTGDLVLLRHIVHDLGDNDAATVLRACAHALPPGGRLALIEMATPETDAHQDE
                     LARDTAVMDLYMMCLFAGGRERSTQEMTELLHSSGLDVANRTPLPGGAVLTLGRPHKTE
                     ELVTEWFRTYLMRDHPELGRPGPVCPFVEPAHRAGTIAIEHAEHIDGENPTELRRLILE
                     TVAKFHDRTWDHGNKALHSLVLVLPQLSRAGCQQLDQTQADLKPELATRGLMMGQFHKH
                     CAETAARNHTFPVSQSPVPLIAIRNMALHDILFLHHDARCFHAYAERFGNRFAKGGVAD
                     PLFVQHYERAAARFRPDQTSGQDETA"
     misc_feature    16762..16777
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.8"
                     /tool="antismash"
     gene            16763..>17422
                     /locus_tag="LC193_RS28870"
                     /old_locus_tag="LC193_28870"
     CDS             16763..>17422
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.5"
                     /locus_tag="LC193_RS28870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_28870"
                     /product="cytochrome P450"
                     /protein_id="WP_226078415.1"
                     /sec_met_domain="p450 (E-value: 1.8e-15, bitscore: 55.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTSTAFTHATAPGALPILGHAPHLMRNPLKFLGSLSRHGDLVTI
                     RLGPRQAHVPCHPEIVRHMLVEYRTFDKGGPLYERAREVFGESLGLCPHARHRHQRRML
                     QPAFSADNIAAYGAIMEQQITALTASWHSGHTFEAFPTFFRLSANTAMRMIFGAGCTDE
                     AATAVQQSIATLTRGLAVDLLLPKATQSLPLPVIRRQTKVRETFLTSIDRLVEEHRV"
ORIGIN
        1 ccgccctgat ggaagcccgc cccgccggct tgcagacccg gcagctcatc gccgccaccc
       61 gcctcacacg ctcgcaggtc gcacgcggca tccagcacct gtgcgacgtc ggcgcggccg
      121 aacacctgac tcccatcatc tggcgctgac gggacggcta cctgttctcc gacgacccgg
      181 gggactggat cgaatacgag aagcggcagt tcctggagat cctccaccgg ctcacccgga
      241 tgatcacggg cacgctcgac ccgcacctgg cccgccaccc ggacgacgaa tgggcccagc
      301 tggccatcgc ccagctcacc gccgtccgcg ccacactggc ccagctcacc cgataacccc
      361 gaaaccgagc cgagccggag atgcccgcac cccgccgacg ccgctacccc tccgacacca
      421 ccgccgcgga atgggccctg atcgagccgc tgctgcccgt cccagcctgc cagacgaaga
      481 ccggcggacg gccggagaag tggccgcggc gcaccgcgtg gacgccatcc gctacatcgt
      541 ggacaacggc gcgaagtggc gggccctgcc cgccgacttc ccgccctggg agaccgtcta
      601 cgcagtcttc gcccgctgga accgggccgg cgtggtggcc tggatacgcg accagctccg
      661 ccgccgcatc cgcaccggcg ccggccgctg cccctacccc gtcacgctga tcgtggactc
      721 gcagtcggtg aaaggcgcct tcaccgtcgg gcaggcaagc cgcggctacg atgcgggcaa
      781 gaaaatcaac ggccgcaagc gacatatcgc cgtcgacacc ctcggtctcc cggagatgat
      841 cacggtgacc ccggccgaac atgaccgacc gggaagccgc ccgcgaactc ctctggcgcc
      901 ttctcctcac tcaccccccc agctcaccca ggtttgggcc gactccgcct acgtcggcca
      961 actggtcacc tgggccggcg aacgccgctg cctcgccctg cgcaccgtct cccggcctcg
     1021 aggcacgaaa gggttcgtcg tcctcccccg ccgctggcgc gtcgagcgca ccatcggctg
     1081 gctgatgaac gcccgcggca acgtccgcga ctacgagcgc ctgcctcaac actcagaggc
     1141 tcatttgacc tgggcactca tcacgctgat gacccgcagg ctgacccgca aaggcacccg
     1201 gccgaactgg tcgaagaagc cctgactgca cgcgcctcgg gcccctactc gccagccgcc
     1261 atagcgatcg agcgcggccg gtggctgatg gggtcaggcg cgcgtgctcg gggcgcgatg
     1321 cagatgggcg cgcgtgaatc gtccgtcctc gaagtcgagc cgtacgccgt ccaggtgccc
     1381 gaaggcctta ccccacaatg agtgatccgc gtcgggaaga cagctgacca gtgttggttc
     1441 aatggagccc ccgtgcgaca cgatgagcgc accgttgcca tccggcacgg accggaccac
     1501 ctcagtccag atcctccggt gctccgctgc cacggcggcg agtcctccgc cgtttgcgat
     1561 caattcggcg tagcggacat acggtcgagg ccaggcccac tgatcgtggt gctcaatttc
     1621 acccgcaacg taaccagacg gcaggacgac ggtgtcatct acggcccacc ccagagcgac
     1681 tgccgtctca atcgccctgg gtgacgcact ggtcaccaca tgcgcgaagg gtcccagccc
     1741 gacgccaaca gcacgtgcaa gcgcgacccc gtgcgcggac aggtgcgaac cgcgaccgcg
     1801 ggccgctccc ttcttcgtcg gcgcatgccg ccgaacctct aaccactgca tttcctgagc
     1861 ctatgggcgc aacgagcgcg aactcggcga ctccgccaca agagtgggcc acccacatgc
     1921 cccgacctgc tacggcgagt caaacacggc ttcctactcg accaggtggc ggttggcccg
     1981 gctccaggcg actcgttggc ccagctcgtc gagatggcct tcggcgaccc agtggacgtg
     2041 aggctggttg ccccgctcgg cgagccggcg gacctgttcg attgtgtcct gctggacatc
     2101 aatgacagcg tcgaccagcc cggtggtgga ggtcagaccg taggccgtgg cgaacagctc
     2161 cagacggtgg cgtcgatcgg gcggctcgga gtactgaagc cagcgcaggc actcgtcatc
     2221 atcccggaac ggcgcgacgt actccaaggc gtaggcgacg ttatacaggc ggcgggccgg
     2281 ccgggcgtag tcccagtcca gaatccctac gggggccgcg ccccgccaga cgatgttcca
     2341 cgggccgaaa tcgccgtgac agaccacctc gccctcgccc ggcctgctct cgccggtgca
     2401 ccagctcagg ccctcgggca ggcgaaagcc cgcgaccgcg tcgtgatccc cacgcaggaa
     2461 gcgggcgaag gcaaccaggc cggcgtcgtc gaccaccctg gcccagccct gcggcccgga
     2521 ctcgccgtcc agatagctga gcacctcgcg tccttcgtca tcgatccctc tcacccgtgg
     2581 cgagtacgga aagtctacgt cttcccgata ccggagcagg gcgtgaacag ccggagtcca
     2641 cggatacacg ggccgccgga cggtatcgcc cacgcgcacc accctgcggt accgatcttc
     2701 ctgtaacaaa gattcatcga tcatgcctgg aaagcccccc ttgctcaaca ccacgacgtt
     2761 ctcaccaaaa cctgatcatg gccgacagct ccgcgcacag ccacatgttt tcgtcgcctc
     2821 ggttctcaaa cacccattaa gcttgttctt taacctttca accgttgcag ggcgatgagt
     2881 gtcttctcgc ggcgaacggt tttgcccacg tcgcagcggg gtgccaggcg cctgttcctg
     2941 gtgccgggtg gtcgcccggg gccgggtcgg tggggtttcg gtgctctggc ggggcagggc
     3001 atgtgctggc ggaggttccg aaacgtccgg cggacccggg ccggggtgag ccggccgtgt
     3061 gcagctggct tctcccacgg gtgccgcagg tcctgggcca gggggcgggc gagccggagc
     3121 tgggtgtagg cggcgatgat cagccacgtc caccggtcgg ccgcttccgg ctcgcgcagt
     3181 cggggtttgg tccagcccag cgtctgcttg aacagccgga acgtgtgctc caggtcgaag
     3241 cgccgcagga acgcctgcca ggcccggtcg atgtccgcat cggtggcacc ggtcttcgag
     3301 gaccacaacc acaccgccgg cgcctcccgg cctttcgaca ggtgcttgac ctccagccgg
     3361 atcaacgtcc cttcgatcaa cgggagtacg cccacatgat ccagccaggc ggcccggtgg
     3421 gtcagccgcg ggtggactcg gtcccacgcc tgggtgacgg ccttgccgta gttggcggtg
     3481 gcggtgcggg tggtgactgc cggttccggc caggtctcgg gcttggcaaa gcggaactcc
     3541 ggcccgtgct tgggcggccg gccgttcgtc ccaggcagcc gcggcggctt cggtaaccgc
     3601 attacgcggt cgccgcggac gcggccgacc agctcgaccg gaaggtcgcg caggacccag
     3661 gccaggcggg tgacgtcgta gccggcgtcg gtcacgacga ggatgtccgg ctcgccgggc
     3721 tgccactggc ccgcggtgat gagccggtcg acgacatcgc ggagctgggt ggcggtgacc
     3781 gcggtggcgt cgccgaccgg gccgagtcgg acggcgtcca ggatctgcgc ccaggacgtg
     3841 gcgcccatct ccagcaccgc gacgaacgag tacggccagc cgggaatgaa ctgcgaggcc
     3901 gtcttcgccc ggccgtagac gtggcagaac agccgctccg gtgagcacgg cgcatccgac
     3961 cgcagccacg gtgagacgtc caccgccagt accaggcgcc cgtcgggaaa ccggggcagg
     4021 ggtaggccgg ccagcaccga ccgcagcctg tcggtgtcga tccggccctg gttgaggccg
     4081 tcgtacatcg cgccgtgccc gcgacggtgc tcgggcagca aggtcagctc caccgccgag
     4141 tgcaccgcac ccggcgcaca caacaccgcg tccgccagct cgaacagctc gtcgccccgg
     4201 acggtcagac acgcgtacaa ctcgtcccgg aagcgtgacg cttccgcgaa cgcatcccct
     4261 ggaacagtct gaggcagcag actcaccctc acggccttcg tcgtggtcac gtgcaccttg
     4321 gtcggagcac atgatcaggc gaaggccgcc tcagcgtccg gcgaatgccc aggtgagtgg
     4381 cctagttcga agctcatttc gacgctggag gttaaagaac aagctaaggg cttccggtat
     4441 tcgtgcctgg ttgccacgcg ggcgggtgac gcgcagtggc cgggcttgtt gacgttcgcg
     4501 ggccccgcgt tcggtcagtc ggtgtgggtg atgcggacga cgaacacggt caggacgccg
     4561 gagctgaccc agtagaccgt gacggcgccg gctaccggcg cctgccgccg gtcgcggttc
     4621 tcgtcgagtg cctgtccgtg gacgtagggg gcggcggcga tgtcggccac ggcggcctcg
     4681 aacagccggc ggcgctggct gctcatcttc cgcagcgcat cccgtgcctg gtcgttgtac
     4741 tggaggcggt accggcggct cacgcgttca ggtccccggc cgcgctgaac ccggtgaagt
     4801 cccccgcctc ctcgcccgcg accgtagaac gacaccgatg cacacattgt tgtcatgctc
     4861 gctggatgag cccgcggagc ggaagtcggc cggcgctacc tggcccgggc gcggcgttcc
     4921 ccgcgcggcg cgcggggaac gcgttcgacg ccgatcggtg atgacatgtg tggtgaaagc
     4981 gcccccggtc tcgtgcagac cagcaacggg gggccgattg gaggcgttca tggcgccggg
     5041 gtgctgccgg cgtgttggag caggccgcgg gggagtggcg tccggccctg cggggtgtca
     5101 gctgttgagg tcgaacacgc tccaggtggt gaacggttcg gcctggacgt agatcctgct
     5161 tcctcgggcg gcgacccgcc ggcggccggg ggcatcaccg ttgggcaggg tgagcaggcc
     5221 gacgtctgtt ggctggacgg aagtttcgct gagttctccg tgggcgagcc ggttccgctc
     5281 ctcgccgtag ccgccgtaga aggcgacccg gtgtctgtgg acggccaccg cgcgggcgcc
     5341 ccgtatgcgg ttcgtccaca ccgtcacgcg ctggtcgggg cgtatttcga cgagcgggaa
     5401 gtccgtgtag gtgcaggccc aggcggaggt gcccgacacg ttcagggcgt agcagtcgac
     5461 aagaccgggg atgcgggcgc cgtcccacgt ccaggtgagc tggcctgtgg cgttccagcg
     5521 gcggattcct gccgggttct cgtcgaagtg cccgacccag atgtggccgg cctcatccgt
     5581 cagcaggtgc tcgatggcgt ccccgacgaa gaaggacgcg gcctggcggc cgagcgcgtc
     5641 gaagatctgg acctggtccc tgtcctcgtg cccgcgggca cgcgacgtgg caacgaggaa
     5701 cctgccgtcg ggcagacggc ccaggtacga cccgctggcc cgcacggcgc tcagctcggt
     5761 gagctcgacg ttgccgtccg gatggacgga gacgaccagg gcgtcgacga gcgggacatc
     5821 gccgccgggc tgcggagcac gttcggccag cagccagtgg gcgccaccga agacatcgac
     5881 cgtactggtc acgatatggc ggccgtggtg ggcgcgggga aggcgggcgt agggaatgag
     5941 ggcggtcttc tgcacgcgcg ggctctcctg agtgggcggt cacggccatc gggcgcttcg
     6001 gtgaggggcg ttcggcggcg cgcgagcggt ggagagcaga ctggggagcc tagacggcat
     6061 ggcccttcct gatcgtcacg cggtgatcat cgtcgacatc cgaccccgtg acaatccttt
     6121 tcgacgcgtc gcccacactg gagtcagccc gccggtagtg ggggagccca tggaactgcc
     6181 acaggccggt gaagaactgc tccagcggcg gtcgcgcggt gtggagtcga gacgattcgc
     6241 ccttgggagg gggccgtgtc ggattcttga acgttggagg gggatgtggc aaggccgcag
     6301 gaagtggtgt cggggctgct gcccgaggtc ctacgtgctg aagtcgcgcc ggagagctgt
     6361 ccggcctggc tgctgcgccc cgggcgcgcg gaatgcgtgc agatgtggga gaccgtggca
     6421 gcggtctacc gggcactgac cggtctggtg ctgcccgagc aggcgccgcc acgcgagcgc
     6481 cgccgcctgg acgcggtgct cagatacgcc gacgggcgcc agcagatcct cgagatcgac
     6541 gaacgccagc acttcaccgg cgcccgggcc acaaccctgg agtgctaccc tgccgacgcc
     6601 gcgctcgggt tcgacgccag ggtctggctg gcccgttccc ggacgctggc gggacgcgaa
     6661 cccgcaggag ggttcgctgc tcctcgcccg cccctcttcc ccggcgccgg tggccgccac
     6721 cgccagcgcg ccttccgaga cacgctggcc gatctcctgc cgcccgcgca cggctggctt
     6781 ccgaccttgc ggatcagcga catcgaggtc accgccgtgg ctgccgcagc ggacccggcg
     6841 gcagcactgc gcctgctgct ggccgcccgc ggtgttcccc agtcccgcct cctgccagga
     6901 tgacgcggtc ggcacgcgcc tcgccgcccc cacgccgtca gcggcgcagt cgccggcaga
     6961 cggcagacgg cagacgcgat gaggatgctg gcgtttgcgt tgcgtggacg tcgagggaga
     7021 tgagcggagc gacgctatcg aggggcgctc cgagggccac tgccgcggtg atgactctgg
     7081 ctacggcgtc gcccgtctct gcggcaccgg gcctacggga actgcccccg caacagcctt
     7141 cgccctctcc gctcacccct gccaagccgg cggctacgtg gacggccgcg ccgctgaccg
     7201 gtagagcgcg gcgatcacat gctcgatgtc tttgccgttg cgcagccggg agcggacggg
     7261 gacacccccg acccgggccg cctccagcac atccggggtg aagcggtgat accgcagctc
     7321 ccgtactgcc tcgggccgcc gcagcccgac caccgcgacc caggcaagga actcctcctg
     7381 gtcggtgact acctggcgcc atgcctgcgc cagggcccag gcttccggcc ggcggtacca
     7441 gtgcagggtg gccaagacca tgtcgaagac gaagacctga aagctcggcc cacccggccg
     7501 cgggcggcca ccgcgctgcc gcggacggcc gccgcgtggc tggtgcctgt gatccagacc
     7561 cagttcgagc ccgtacgact gggccatctg ggcgggtgag agcggcctgg tgcggcgctt
     7621 cggcatgttg gccggggtcg gcgccgcgcc ggagttggcg ggcacatggc cgcgcaggaa
     7681 ccgggcgatg gcggcggggt cgcggggccg gctgaacctg aggagcggca ccgcggccgg
     7741 gcggggcctg cccgcgtcgt cgttgtccgc cgcctcctgg tcctcctcgt cgtgcttcac
     7801 cagcgccgcg tcgatccccg cgcggccgtc gtcgttcagc ctctcgacca tcacgggatc
     7861 atgacgcgga cgggcggaac ggcgccaccg aattgacgcg gtcccggcgc cgcggcgcgg
     7921 gaccgagccg accgctcagg gcgcgctccc ctcgaccagc ggccgcagct cctcctccag
     7981 cgcatcgctc tccacgcgct gccaatacgt cgacggggga gcgtacgacg tctccgggca
     8041 actctcgtcc gggctggtcg taccgtccag gctgaactcg gcgacctgct cgcccgtctt
     8101 cgcctcgaac acccggtaga tgtaccgctc ggaaaacacc tccggatcgc gatccccgta
     8161 cggggcgccc cccaggtagc tgcaatcgcc gaccttctcg ccctcgaact cgtcgtccga
     8221 gtactcgcac accaccagct gggtgaagtc gtagggcgcc gaccccgacc actcctgcgg
     8281 tagctgaggc acctccacct cgggaaggga gcccggccgg aacagcacgg ccggatgcgg
     8341 ccctggcccg ctccacgccg ggccgtccgg ggagtaggcc accaccgccc cggcgtcgaa
     8401 cgggtcaccg ccacaggcgt cgtagccgtc cctggtctcc ggcggcccgg gcggcatcgg
     8461 gatctcgcgg ggcttcgggc tggtcggcac cgcgggcacc ccgtcggtcg gcggctcccc
     8521 ctcgccgccg cacccgcaca gcacggccac ggcgaccgct ccgggaacga ccccggccct
     8581 ccgacgacgc gtacgtttca caagacgccc ctgcccccga acgcccatcc ggaatccggc
     8641 ccgagacggg cgccccatcg tacagcgctg cggaacaccg cggtgccaac acctcgccac
     8701 ccctcgccct tgatacccga ggaccgccgc cgggcagcgg ccaccgggga cgcgcggccg
     8761 ctaccgcacg cccccggacg ccacccgcgc ctacgcgagc ttccggccaa tcccgcacag
     8821 ctcgtgtgtg atatccgtcg ccgcccccac ctcggcaaac tgaggacgcc actgcgggca
     8881 gcggaacaac cccgggctcg accagctcca aaccgtcgaa gaacgccacc atctggcccg
     8941 ggctgcgcag cgtatacggc accgcaccgc cctcgttgta ccggcgctgc gcctcggcga
     9001 actccaggtt cgtgtccgtc ccgtcggcca gcgccacata actgcccgcg ggcagcccct
     9061 cgaccaagcg gcgaacgatg gcgtgcggcc gctcctcatc gccgatgtgc cccagcacgc
     9121 cgagcatggt caacgcgacc gggcgggaga agtccagccg ctcggccgcg gcggccagga
     9181 tcgcgtcggg atcgcgcaca tcggcctcca cgtaatacgt gcggccctcc ggcgaactcg
     9241 tcagcagcgc ccccgcatgg gcgagcacca gcggatcgtt gtccacatac acgatgtgcg
     9301 cctccggcgc gacgcgctgc gcaagctcat gagtgttgtc ctgggtgggc agccccgtcc
     9361 cgatatcgag aaactgccgt atccccgcct caccggccag gaaccgcacc gcccggccca
     9421 ggaaataccg ctgcccacgg gcgatgtcca caataccggg gaacgcctcc cgataggcct
     9481 caccggccac ccggtcgacc tcgtagtagt ccttgcctcc caataagtag ttccaaatgc
     9541 gggccgaatg cggtaccgac gtgtcgatgg gccgcgacgc gctctcgctc atgctcacgc
     9601 tcctctgctc agcggatacg gccccatccc accatgcgga cgccccgcca gcccttccgg
     9661 ccccaccccg aacggccccg acaagcaagg cagttcggcc aagtccggca gcccccgcgc
     9721 ccccacccgc cgggcgcggc taccactccg caggcgtgac cggtcccgaa cggcctgcga
     9781 tacacctgtg agccgttgcc cgagacggca gacaagcaag ggatacctgg ccgcgcacgt
     9841 ggcggaaagc cgtccgtggc tcgttacccc ggtgcacaag tctgccccag cagaaggaag
     9901 cgatcttggc gctcattccg caaaggctct tggtaccgca acgagcacca caacagtgcg
     9961 tgcaccgatc ggcccaccgc gaagggggcc cggtcgcccc atgaacgaca tccacgccca
    10021 caacaccctc gcacgcggaa tcgacaacct cctggcgcgc caactcgacg acggacactg
    10081 gtacgaagga ccgcacacca acgtcagcgc cgaatcggcc gacatcatcg cccgacactg
    10141 cctgggcatc accgacacgg ccgccctcga acgcaccgcc ctgcgagtac gccgaggaca
    10201 gcacgacgac gggtcctggc ccatgttccc cggcgggcct gggcacctgt ccgtcaccgc
    10261 cgaggcatac ctcgcgctgc ggctggccgg cgacccgccc gacgagccgc acatgcggtc
    10321 cgccgcgcga ttctgccgcc gccacggcgg gctcggcgca gcacgcaccg aaacccactt
    10381 ctggctcgcg gtactcggca tccgcgcctg ggaccgcgtt ccgcccatcc tgcccgaaca
    10441 gatcctcttc ccggccggca ccccggtcgc agtccgctcg ctgggcgtat ggtcacgcca
    10501 cctgctcaca ccactatcgg tcatcgccgc ccagcgcccc atctggccgg ccggattcga
    10561 cctgccagaa ctgtacgacc ccacatcccc agccgagacc gcaccacccg gcaaagccga
    10621 acaagtcatg cgcgcctacc acaaacaccc gctgcgccca ctgcgaggcc gggcactggc
    10681 gcgggccgaa ctatggctac tgcgcaacca gcaggccaac ggctcctggt tccacgtctt
    10741 cctgttcacg gcactgggaa cactggccct caaagccctc ggctacacca ccgacaacaa
    10801 cgcctaccgc tccgcgctcg ccgcgctgga cagcttcggc gcacccctcg aaacccccga
    10861 cgggaccgca cgccgaatcg tcccctgccc cggacccgta tgggacacgg cctactcact
    10921 gctcgccctg ctcgacgcag gggtggagcc cacccacccg gcgatcgaac gcgcctgcac
    10981 ctggctcatc gcccagcagt ccaccagcgg cggcgactgg caacgcgacc ggccccgggt
    11041 acctcccggc ggctggccgt tctccccggg cctcaacaac tacccggacc tggacgacac
    11101 cgcgatcgcc atcaccgcgc tcacccggct ccgcgacagc aacgggcaac tgccgcccgc
    11161 cgtggcacca gcggtcgaac gcggccaagc ctggctcgcc ggcctccaat cccgcaaagg
    11221 aggctgggcc gcctacgaat ccggcgacct gtcaccgctc accgaactct cgcaacgcct
    11281 cccctacaac gaccacggcc cgatgctcga cgtacccacc gccgacgtca ccggccacgt
    11341 cctcgaagcc ctcaccgccg ccgcaccaga aggcggagca cgaaggccat cggccgcggc
    11401 cgaatggctc ctcgcccagc aagaaccgga cggctcctgg ttcggccgct ggggcgtcaa
    11461 ccacatctac ggaaccggaa gcgccgtccc cggcctcgtg gccgccggaa tcggccccgg
    11521 cgacccacac atccgacgcg cagcggactg gctgcgccaa caccagaacg cggacggcgg
    11581 ctggggcgag gactgccggt cctacgacga cccggcccac cgcggccgcg gccgaagcac
    11641 cccctcgcag accgcctggg ccctgctcgc cctgcacgcc gcaggcgtcg gcgccgacga
    11701 caaccaggta cgggccgcat tcacctggct ggccgaccac cagcgccccg acggctcatg
    11761 ggacgaagaa gtctttaccg cgaccggcca gccgggcgag atctacttcg cctatccggc
    11821 gatcgtccag gcaatgcccg tcatcgccct cggccgatac ctcgcaccca cacagccccc
    11881 cggccaaccc gacccaccgc acccccggct caccgcggag caggagagcg gccatggcac
    11941 cgcgtgacgg cgaaaccctg tccgaagccg agccgacgca ccgacaacca gcccagaact
    12001 ggacagcgct gccaccacac gaactggtga acctcgtccg ccgcagccca ggaaccgcag
    12061 gccccgcgcg gacagcacgc ctgctgatcg ccctgagcag accgcggaca tgcacgccca
    12121 gcctgaccat ttacgcgctc ggctacggca tcgtcgccgg cgaagtccac tggcagttct
    12181 ggctcggcgc cttcctgatg ctgacaaccg gaatgctggc caacctctac aacgtccaca
    12241 ccgacctgga cgaggacagc gtcaacatgc ccggccggct cggcctggtc ggcgagatcg
    12301 gctggcgccg ctaccgcacc accctggcca tctggagcgc ggcagtggcg ctgtcctcca
    12361 taccgctcgg acccggcccc ctcggcatct tcctgctcgt actggcaggc tcccaccagt
    12421 actcctaccg gccactgcga ctcaaagcca agcccgtcgc cggcctgctc ggcttcgccc
    12481 tcgccggcta cggccctctc atattcggct acaccgtggc ctgcaccgcc accggccaag
    12541 ccgacccgcc acccaacccg gacacgctcc tgtggctgct cgccctcatc accctgtggc
    12601 tcgtggcaaa aggcctggtg aaaaacgtgc ccgactacga cggcgacaag cgcaccggac
    12661 tgcgcacctc cgccaccgtg ttccccactc gacgagccgc cgcactcgca gccggtaccg
    12721 caacagtcgg cgtgcacctg gccgccccgc tgttcacctt cctcgcccac ggaaacgagg
    12781 gcgcgggcag cctcagatgg ctgctgctgg tacccgccgt gccgttcgcc gtactccagg
    12841 caatccgaat gacccgagcc gtcggcaccc acgccaacag cgtcctcaaa caggacatgt
    12901 ggttcacctt cctgttcatc gccctggtcc tcgcgctctc cgcacccgcc gcgatcaccg
    12961 caccagcgct cgccgccaca gcactgctca tggtcgccgt cgacgccctc cgagtcgact
    13021 cccgcgaaaa caacctcacc cgcacaacca cgggctgaac ccgcggcgcc cgcaccccgc
    13081 cccaccccca accgatggga gaatgccgtg acttcacacc tgtcagggcc ggtgaccgcg
    13141 cccggcggcc gacgcccgcg cctacccggc ccacggacgc cacggcaagt cgcgacggcg
    13201 ctcgacagct tccgggactc ggtggccgcc ggaatgagcc acctgcacca cacctacgga
    13261 cccgtcgcgg ccctcggcat cggaccactg cgctggacct tcctgttcgg caccgacgcc
    13321 aacgaactgg tactcggcaa caccgaaaac ttcgaattct cctacggcgg cctccaagcc
    13381 atcgccggcg acaccgccct cgtagccctg ccgaacgccg aaaaccggac catgcgacaa
    13441 ctgctgcgcc cactgttcga tcgcgaacac gtggacgcct acgccgaccg cgtcctcgac
    13501 cgggtacgcg accgcctcgc agcctggccg cggaacacga cagtggacgc ctacaccgaa
    13561 ctacggctcg cagtgcgcct ggcgtccgtc gactccttca tcggccccgg cgtcctcaac
    13621 cgcgaaggca acacgctcga caccaccctc gaacaactcc acaccgtact gaaccgctcc
    13681 tccatcctga ccctgctggt atggaacgcc ccccgcctgg gccgactacg gctgcgaaag
    13741 cccctcagcc gcatcgaccg ggtcgtgcac gccgaaatca cccgcaggcg ctccggggcc
    13801 acacccacac cggatccgat cgatcccatc ggcttcctgc tgcgccccgg catctacccc
    13861 gagctgccgg ccggagacca cacagtccgc gacacggtcg tcagcctcct catcgccagc
    13921 tacgacccca ccagctccgc gctcggctgg tcgctgtacg gcctgctggc caacccggaa
    13981 gtcctggccg aggcgaagcg ggaagtcgcc cgcgaactgg gcgacgaacc ggtgcgggcc
    14041 gccaccgcgc gccggctcaa atacctcggc cacgtagtcg cggaagccat ccgagtccac
    14101 ccaccagtag tggcgagcgc ccgccactgc gtcaaaggat tcgaagtcca cggccaccgc
    14161 atccccgccg gcagccgcct catgctcagc cagttcacct cccaccgctc gcccgactcc
    14221 tggcccgacc ccgaacgatt cgaccccgac cggtgggaca ggaccggcac cgtgaccgcc
    14281 gccgtcccgc ccgccgccta cttcccctac ggctccccac gccgcaggtg ccccggcagc
    14341 ggcatggccg cagtcatcgt gcccgcggta ctcgcggccg tgctacaggc aggggacatc
    14401 accctggccg acaacagccc accccggctc gacggattcg ccgcactgcg gcccaaagcc
    14461 ggactccccg tgcgcgtcca ccagtcgcac tgagccacac cagaacacga aacgccgacg
    14521 cgaaccggca ccaaacaacg aaacagacca aacaacgaaa cagagggaca cgacgatgac
    14581 aacgatcaac cagccgaagc cggccgtgga caacaacacc accgcgccca gaaccgcccc
    14641 gctggaactg tcgagcttcg accgctacct cctggcacac accaaagcca gcacgcggtg
    14701 gggccacgtc gtcgccatgg gcgccgccct cgcaaccccg gcaacagccc cgaaaggcaa
    14761 gcgcctgcgc cggacactgc tgggcgtgcc ggtattcttc tccatcgcct ggcccagcca
    14821 cttcatcttc gaacgcaaca tgccggtcgg attcaccgac tccaaagccg cattctccgg
    14881 cgacctccgc atgatctgga tgatggtcac cggacgcaac cacgaactcg ccgagcggat
    14941 cgaggaactc cagcgactgc tcgccgacca ggcgggcgac cgatgacggc tgaggacgtc
    15001 cgacgcctga tctacgggca gatcgtgtcc aaagccgtgc agacattcgt cctcctcggc
    15061 ctgcccaacc tcatgcggga cgccgaacac cccctcgaac aattgacgcg gtccgtcggc
    15121 gccaacccca cctcactgcg ccgcctgctg cgagcactgg ccgccttccg aatcgtccag
    15181 gaaaccgccc acgacacctt cgccctcgaa ccactcggcc accaactacg ctcggacacc
    15241 ccccgcacag cacacccgac cgcactgctg gccgccaacc tcgtaggcca ggcatgggac
    15301 ggaatggccc acgccgtccg caccggcaaa cccgcgttcg aggagatcac cggcaccccg
    15361 ttcttctcct acctgagcga caacccgccc ctcagatcga tattcgacgc ctcccaagcc
    15421 gccggactcc acgccgaact ccccggaatc ctcaccgccc tcggccccac cccgccccga
    15481 gtcgccgtgg acgtcggcgg cggtgacggc gcactgctcg aacacatact cacccaccac
    15541 cccggcaccc gcggagtcct cctggaccgc ccagaatccc gcgaacccgc caccgcacgg
    15601 atgaagcgcg ccggactcgc agaccgattc accttccacg ccggggactt cctcaccgac
    15661 gacgtgccga cgggagacct ggtactgctc cgccacatcg tgcacgacct cggggacaac
    15721 gacgcggcca ccgtcctccg cgcatgcgcg cacgccctgc cacccggcgg cagactcgcc
    15781 ctcatcgaaa tggccacacc ggaaacagac gcacaccaag acgaactagc ccgggacacg
    15841 gccgtaatgg acctctacat gatgtgcctg ttcgccgggg gacgcgaacg cagcacacag
    15901 gaaatgaccg agctgcttca ctccagcggc ctcgacgtag caaaccgcac ccccctgccc
    15961 ggcggcgccg tactgaccct cggccgacca cacaaaaccg aagaactcgt cacagaatgg
    16021 ttccgcacct acctgatgcg cgaccacccc gaactcggcc gccccggacc agtctgccca
    16081 ttcgtcgaac cagcgcaccg ggccggcacg atcgccatcg aacacgcaga acacatcgac
    16141 ggcgaaaacc ccaccgaact acgccgcctg atactcgaaa cagtcgccaa gttccacgac
    16201 agaacatggg accacggaaa caaagcgcta cactcactcg tcctcgtgct cccgcaactc
    16261 agccgcgccg gctgccaaca actcgaccag acacaggcag acctaaaacc cgaactcgcc
    16321 acgcgcggcc tgatgatggg ccaattccac aaacactgcg ccgaaaccgc agcacgaaac
    16381 cacaccttcc ccgtatctca gtcgccggta cccctcatcg cgatcagaaa catggcgctc
    16441 cacgacatcc tgttcctgca ccacgatgcc agatgcttcc acgcatacgc cgaacgattc
    16501 ggcaaccgct tcgccaaagg cggcgtcgcc gacccactgt tcgtacagca ctacgaacgc
    16561 gcggccgccc gcttccgacc ggaccagacc agcggacaag acgaaacagc gtgacacgcg
    16621 cccagcaaac cccgccggtg gcgcccccgg ccgccaagac gaccccgaaa accggcaccc
    16681 cagccctcca cttgatcagc ccaaaaacag gcaagacccg cgccccaacc gccgacagcg
    16741 cccgcaaaag acaggtcaca caatgagcac cagtaccgca ttcacccacg ccacagcccc
    16801 cggcgcccta cccatactgg gacacgcccc ccacctgatg cgcaaccccc tgaagttcct
    16861 cggctccctg tccaggcacg gcgacctagt caccatccgc ctcggccccc gacaagccca
    16921 cgtaccctgc caccccgaaa tcgtgcgcca catgctggtc gaataccgca ccttcgacaa
    16981 aggcggccca ctctacgagc gagcccgaga agtcttcgga gaaagcctgg gcctctgccc
    17041 ccacgcccga caccgccacc aacgccgcat gctgcaaccc gcattcagcg cagacaacat
    17101 cgcagcctac ggcgccatca tggaacagca aatcaccgca ctcaccgcct cctggcacag
    17161 cggacacacc ttcgaagcgt tcccgacctt cttccgcctg agcgcaaaca cagcgatgcg
    17221 catgatcttc ggcgccggct gcacagacga agcagccacc gccgtgcagc agtcgatcgc
    17281 caccctcacc cgcggcctgg ccgtagacct cctgctcccc aaagccaccc aaagcctccc
    17341 cctgcccgtc atacgccgac aaaccaaagt ccgcgaaaca ttcctcacct ccatagaccg
    17401 cctcgtcgaa gaacaccgcg ta
//
