LOCUS       NZ_CP084541            22571 bp    DNA     linear   CON 20-NOV-2024
DEFINITION  Streptomyces marincola strain SCSIO 64649 chromosome, complete
            genome.
ACCESSION   NZ_CP084541
VERSION     NZ_CP084541.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces marincola
  ORGANISM  Streptomyces marincola
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 6629020)
  AUTHORS   Shi,S.
  TITLE     Strepomyces indimicinicus sp. nov., an antibiotic producing
            actinomycetes isolated from the marine environment
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6629020)
  AUTHORS   Shi,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2021) Key Laboratory of Tropical Marine
            Bio-resources and Ecology, South China Sea Institute of Oceanology,
            Chinese Academy of Sciences, 164 Xingang West Road, guangzhou,
            Guangdong 510301, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. V6.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 444.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_020410765.1-RS_2024_11_18
            Annotation Date                   :: 11/18/2024 03:45:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,763
            CDSs (total)                      :: 5,689
            Genes (coding)                    :: 5,612
            CDSs (with protein)               :: 5,612
            Genes (RNA)                       :: 74
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 77
            CDSs (without protein)            :: 77
            Pseudo Genes (ambiguous residues) :: 0 of 77
            Pseudo Genes (frameshifted)       :: 21 of 77
            Pseudo Genes (incomplete)         :: 60 of 77
            Pseudo Genes (internal stop)      :: 2 of 77
            Pseudo Genes (multiple problems)  :: 6 of 77
            CRISPR Arrays                     :: 10
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:57:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6565361
            Orig. end                         :: 6587932
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP084541.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22571
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="guanidinotides"
                     /region_number="35"
                     /rules="(pgm1 and pgm_amidino)"
                     /tool="antismash"
     cand_cluster    1..22571
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(pgm1 and pgm_amidino)"
                     /kind="single"
                     /product="guanidinotides"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22571
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12571](+)"
                     /cutoff="20000"
                     /detection_rule="(pgm1 and pgm_amidino)"
                     /neighbourhood="10000"
                     /product="guanidinotides"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12571
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(pgm1 and pgm_amidino)"
                     /neighbourhood="10000"
                     /product="guanidinotides"
                     /protocluster_number="1"
     misc_feature    complement(349..363)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.6"
                     /tool="antismash"
     gene            680..910
                     /locus_tag="LC193_RS28610"
                     /old_locus_tag="LC193_28610"
     CDS             680..910
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1265: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058047.1"
                     /locus_tag="LC193_RS28610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_28610"
                     /product="ferredoxin"
                     /protein_id="WP_226078298.1"
                     /transl_table=11
                     /translation="MNVYLDQDKCVASGQCVLAAPGIFDQREEDGIAVLLDPAPPAGRA
                     RDLHDAEDLCPALAIRVDDAQGTPATGDRPA"
     gene            986..2836
                     /locus_tag="LC193_RS28615"
                     /old_locus_tag="LC193_28615"
     CDS             986..2836
                     /EC_number="1.14.13.-"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005484320.1"
                     /locus_tag="LC193_RS28615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_28615"
                     /product="flavin-containing monooxygenase"
                     /protein_id="WP_404819502.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.9e-09, bitscore:
                     35.0, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPHQDRPASPAPHDSVAPPPPGPLGFDPDALRERYRAERDRRIRP
                     DGKRQYRSTTGAFGYYVDDPYTTGTPDRTPLEDRMDAVIVGGGFGGLLAAARLRQAGLR
                     DIRVIDRAGDFGGTWYWNRYPGIQCDIESYIYLPLLEEVGSIPAWKYAPGEDIRQHARA
                     IGQHFGLYRHACFQTEVTGLRWDDTTEEWLVSTDRGDRVTARWVVLSGGPFSRPKLPGI
                     PGIEDYRGHTFHTSRWDYAYTGGHAGGGLDGLGDKRVGLIGTGATAIQCVPHLGRDARH
                     LFVFQRTPSSVDVRANRRTDPGWARSLTPGWQRRRRDNFLLHVAGRPGAGDLPEDLVND
                     GWTTSARLLRSLLPGDDTSPRDSEERRRAGELADFRKMNELRARVDAVVHDPHAAEALK
                     PWYRYMCKRPTFSDTYLQTFNRDNVTLVDTEGLGVERITGNAVVVAGRAYEVDCLIFAT
                     GFDIGAPPAERIGFPVRGRAGRRLAEHWQDGPRTLHGIHSHGFPNLFHLGSLHNAVSVN
                     FVHALDEQASHIARVVAEAVRRGVRRVEPSADAERKWGDTIRETAPDTHRFLAECTPGY
                     YNDEGMPGRRGDSYGRGPLAFHALLEEWRSGDGMGEVMVT"
     gene            3287..5029
                     /locus_tag="LC193_RS28620"
                     /old_locus_tag="LC193_28620"
     CDS             3287..5029
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014627134.1"
                     /locus_tag="LC193_RS28620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_28620"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_226078300.1"
                     /transl_table=11
                     /translation="MADRPNAPARTADGLGLGDALERAAVGVCAVDDAWRVLWANDRAL
                     GLLARSAEDTLGQDVHDLLHCDVPGLPLGRHPRERSRALLRHTSRTHPARSPHGGGTPL
                     SLQCFALPCEPNDHGVTALIAFQAAEPPEESFAPPTAPPRALSEKERLALLADTTAQLI
                     DNVDAHESLRRVVGLMLPRLAEWAVIDLITEANEVTRSLVVRARAGALEVHEELQGPMP
                     PVPETSTMPLSKALRGAASTLTGPETYEAPPDSRIAVEQRKLFRATGIETAAIAPIRGP
                     REVLGALTLGRTSRHEAFTTGDLGLLEDIARRIGIALENARHYQRQRQVAETMQRYLLP
                     QLPELPGVEMTTRYVSAPDASHVGGDWYDAFTLPGGDAALGIGDVVGHDLEAAAGMAQL
                     RNMLRAFAWSQDQRPHRIVECLDEAMAHISDVRMATLILARLTADADGHWRLRWASAGH
                     PPPLLVDHEGATRYLDEGNGLLLGSDISAPRLDAHVDLPPGSTLVFYTDGLIETRRQSL
                     DVGLERLRRHAASLARRPLDLFADQLLERTRPADNDDDVALLAIRIPHDTARTPRTVAP
                     GPGR"
     gene            complement(5174..6802)
                     /locus_tag="LC193_RS28625"
                     /old_locus_tag="LC193_28625"
     CDS             complement(5174..6802)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF044287.2"
                     /locus_tag="LC193_RS28625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_28625"
                     /product="hypothetical protein"
                     /protein_id="WP_226078302.1"
                     /transl_table=11
                     /translation="MPRQEQPLEQGDTPLLRFAADLRRLRDEAGGPTYRQLALRAHTSA
                     ASLSVAASGRRLPTLAVTLAYVGACGGDVGGWERRWRDVASALAAAGHPRPPEAVPGDR
                     HTVPYLGAAPFGPGDSPWFFGRDALVTELRERLRHRRVVTVTGASGAGKTSLLNAGLIA
                     RLRAEGHRGRVVTLTPGPCPMREAGRWLTRLGDGPFPDDEETVVVIDQFEELITACRSP
                     AERARFLGLLESAGTSRAGHHRIVVCTRTDLHDRCLGRLPAASALFVDPLVVGPIPPEE
                     LHRVIAEPAARAGCAPEHALVAVLTAATAGQPGALPMLSAVLKETWLHRGGHALTLTAL
                     RAAGGIEDWIDRSAEAAYAGLPDALHPRARDLLLRLATANAPTALGPRAVALSDLDEDA
                     ATRAVLERFARARVVTLDRDRAVWSHTAVPRSWTRLARWAETGSEDWRVHRRLAEAARA
                     WHDSGRLPGRLYQGADLAEARALCGREHHEPTRRERAFLQAAARAESARHRAAEATRAR
                     LRLQRRLIVGLAALVVALAAAWATA"
     misc_feature    7014..7031
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.47"
                     /tool="antismash"
     misc_feature    complement(7102..7117)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.81"
                     /tool="antismash"
     gene            7164..7997
                     /locus_tag="LC193_RS28630"
                     /old_locus_tag="LC193_28630"
     CDS             7164..7997
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004942076.1"
                     /locus_tag="LC193_RS28630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_28630"
                     /product="CoA ester lyase"
                     /protein_id="WP_226078304.1"
                     /transl_table=11
                     /translation="MKFSRYCRSLLSTPATAVSRYTPCHRSGADIAMVDLEDSVPPERK
                     EEARRLAARFFTGPGGPARPAIRINTVGEPDGLRDLLALRQYPVKPALVLIPKAESPRD
                     IEIVEHALAPTCPDTEFFAVVESPRGLANAPAIAAASPRLRAMVFGSADYSFAIGASLS
                     WEALAYARASLVNSARAAGIEVMDSPYFGALDTDGLRREAAAARDFGFSGKAAVHPRQI
                     SVINEAFSPGPALLDQARKVVAAGRETGRGVTMVDGVMVGVPFFEASQQLIEEFG"
     misc_feature    8095..8113
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.24"
                     /tool="antismash"
     gene            8104..9336
                     /locus_tag="LC193_RS28635"
                     /old_locus_tag="LC193_28635"
     CDS             8104..9336
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (177-398). E-value:
                     9.9e-12. Score: 36.6. Matches aSDomain:
                     nrpspksdomains_LC193_RS28635_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1109: 8-amino-7-oxononanoate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004942074.1"
                     /locus_tag="LC193_RS28635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_28635"
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="WP_226078306.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 9e-10, bitscore:
                     36.6, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQNSPPDITGPHRHRNNASMLRAADPAWQRAADAGLIGVHVDTP
                     DANNRLVVRETGHEFVNMCSVGYLGLNHHPAIIEGAIDALREAQATWLVVSTTRIRHNL
                     LVRMEEELGDLFGAHILPGTSCTALTAGILPLVASGHLTDGQPRVMVFDRYCHFCMAYV
                     KPVCAEETLVLTCDHNDLDYLEKICRQYPRVAYVADGAYSMGGAAALAGLRDLQERYGL
                     FLYIDDSHSLSILGENGEGFVRSQLEMNDLTVIVASLGKGFGTGGGVAMLGSRTMFEFL
                     HRHAGPVGWSQNMSLPLVGASLASAAIHRSPELGELQRRLRENIDHFDRTFPTAFAGNG
                     LPVRRITVGEPDDAVRLSEELFKRGFYSSAVFFPIVPRGEAGLRIMLRADLTTELIDDF
                     TGNVRDVLSTF"
     aSDomain        8635..9297
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_LC193_RS28635_Aminotran_1_2.1"
                     /evalue="9.90E-12"
                     /label="LC193_RS28635_Aminotran_1_2.1"
                     /locus_tag="LC193_RS28635"
                     /protein_end="398"
                     /protein_start="177"
                     /score="36.6"
                     /tool="antismash"
                     /translation="HNDLDYLEKICRQYPRVAYVADGAYSMGGAAALAGLRDLQERYGL
                     FLYIDDSHSLSILGENGEGFVRSQLEMNDLTVIVASLGKGFGTGGGVAMLGSRTMFEFL
                     HRHAGPVGWSQNMSLPLVGASLASAAIHRSPELGELQRRLRENIDHFDRTFPTAFAGNG
                     LPVRRITVGEPDDAVRLSEELFKRGFYSSAVFFPIVPRGEAGLRIMLRADLTTELIDD"
     gene            9390..10004
                     /locus_tag="LC193_RS28640"
                     /old_locus_tag="LC193_28640"
     CDS             9390..10004
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004942071.1"
                     /locus_tag="LC193_RS28640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_28640"
                     /product="MaoC family dehydratase"
                     /protein_id="WP_226078308.1"
                     /transl_table=11
                     /translation="MHEAGAEPADRGAVPPGQATAEPAPPTGFERIGRQRYRELVGFLY
                     EEFTVGDVIEHRPGRTVTEMDNVLMSMLSMNDAPLHIDAAYCETLPWGRPLVSSLVTLS
                     IVGGMTARSTSGRALANLGWDHIKLPAPVFAGDTLYAHSEILAKRRSRSRPGQGIVSCR
                     TTGTKSTGEVVLVFERSFLVPCRETAAAPPANAGAPAGEGE"
     gene            10001..11350
                     /locus_tag="LC193_RS28645"
                     /old_locus_tag="LC193_28645"
     CDS             10001..11350
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     guanidinotides: pgm1"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF037360.5"
                     /locus_tag="LC193_RS28645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_28645"
                     /product="peptide ligase PGM1-related protein"
                     /protein_id="WP_226078310.1"
                     /sec_met_domain="pgm1 (E-value: 7e-169, bitscore: 560.2,
                     seeds: 80, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTLLIGNSRTEDMVGDLSRLSARAREAAAHTAHRLLWWAREGDI
                     LVLPTAPDDAFADYVAGLTGTPRSTVTVRVPAPGALGEHLLTPDRLADTDLQRTLAEDL
                     GAPPSGGTPGLRVLPVYADQAVAQLAHRLGAARALPGHAFHAQGGSALVNSKAAFRSVA
                     AGAGVPTAPGTVVTDPNEAARAIGGLLGAGHCAMVKQEFSGGGLGNEVLAPVPGVEPAG
                     APRAVVLPDDTAVRAYVTERWPWLTEGGRHRLVVERYYTGAVPVYAEFDLTDTAVELTG
                     TGEMLMDPVVVGEIVPASATLPADAVAELVAVGRRLCEAYRALGYRGTISADAYRTPEG
                     EIRFCEANGRITGSTHLHTIMAARLVGPALRPRRVLLGGECPAPSFRAALSALTAANLG
                     FDPAAGAGVVLVNGSAPGAGTVTYCAVADDAAGVRDLRHALEAALARAQS"
     gene            11432..12571
                     /locus_tag="LC193_RS28650"
                     /old_locus_tag="LC193_28650"
     CDS             11432..12571
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     guanidinotides: pgm_amidino"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004942068.1"
                     /locus_tag="LC193_RS28650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_28650"
                     /product="glycine amidinotransferase"
                     /protein_id="WP_226078312.1"
                     /sec_met_domain="pgm_amidino (E-value: 4.6e-189, bitscore:
                     626.2, seeds: 95, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLNSYDGWSPLREVVLGSADNYTAHDRELSFDLFFHDETPYSRI
                     YYPRHVTSGAAPGRRTTIKKRYLEELREDVEGMAEIFAQLGVTVHRPLPLDASTGEVRT
                     PAFAAAVVPPLNVRDNSIVFGDEIIETPPLVRSRYFETQFLKPVYAEYFRRGARWTVMP
                     RPMMTDASFDLSYVADAAKPGSLIEPITDSRPSPYDTGFEMMIDGAQCLRLGRDVFVNV
                     SNANHALGCDWLERHLRGRFRVHRLHRLADSHIDSTVLALRPGLLLVRTPGVAERLPKA
                     LQSWDMIFPPEPEDNNFPDYEDDDLILTSRYIDLNVLSVSPDTVLVNAACPELARTLEG
                     HGFTVVPVRHRHRRLFGGGLHCFTLDTVREGSGPEDYLD"
     gene            12633..13598
                     /locus_tag="LC193_RS28655"
                     /old_locus_tag="LC193_28655"
     CDS             12633..13598
                     /NRPS_PKS="Domain: PKS_ER (23-317). E-value: 5.3e-39.
                     Score: 126.1. Matches aSDomain:
                     nrpspksdomains_LC193_RS28655_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004942066.1"
                     /locus_tag="LC193_RS28655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_28655"
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_226078314.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 5.8e-20, bitscore:
                     70.0, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGAGAGAGTMRAVVLRRFGGPGQLRTESVPQPAPREGESVIDVTL
                     AGLNFADLEIRQGAYAPPPLPAVLGVDVVGRRRSDGRRVAALLREGGGYAQAAVARDAY
                     TVDVPDHIDDAQALGLLEQGCTAYGALVTAGRLRPGESVAVAAAAGGVGHLAVQLALAL
                     GARTVAGIASTPAKRRFVRSLGARVAVGAPERLSAELPEGVDLYLDSVGGPALRAGLAA
                     LAPFGRLVTIGERGAGPGSSVPVEELTGRSVGVHGFWMRHVLADPALFARTADALFALA
                     GRGLVRARVDRVVPLDGVGAAHEAMAARATLGKVLVDVRA"
     aSDomain        12702..13583
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_LC193_RS28655_PKS_ER.1"
                     /evalue="5.30E-39"
                     /label="LC193_RS28655_PKS_ER.1"
                     /locus_tag="LC193_RS28655"
                     /protein_end="317"
                     /protein_start="23"
                     /score="126.1"
                     /tool="antismash"
                     /translation="LRTESVPQPAPREGESVIDVTLAGLNFADLEIRQGAYAPPPLPAV
                     LGVDVVGRRRSDGRRVAALLREGGGYAQAAVARDAYTVDVPDHIDDAQALGLLEQGCTA
                     YGALVTAGRLRPGESVAVAAAAGGVGHLAVQLALALGARTVAGIASTPAKRRFVRSLGA
                     RVAVGAPERLSAELPEGVDLYLDSVGGPALRAGLAALAPFGRLVTIGERGAGPGSSVPV
                     EELTGRSVGVHGFWMRHVLADPALFARTADALFALAGRGLVRARVDRVVPLDGVGAAHE
                     AMAARATLGKVLV"
     gene            complement(13613..14068)
                     /locus_tag="LC193_RS28660"
                     /old_locus_tag="LC193_28660"
     CDS             complement(13613..14068)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LC193_RS28660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LC193_28660"
                     /product="hypothetical protein"
                     /protein_id="WP_226078316.1"
                     /transl_table=11
                     /translation="MRKGIRAAVPTAVVALVLAGCGGDSDGGPFSGLPETPDSEGSEVR
                     LPEGGADGGAPANEQIQGAWVLVGEGADPPYTTNISFIMDEVHFVESTSVEGDVCQGTV
                     SEGVITVECVVSGEMRWPDTRATVALDGEQLVVTWESGIVQTYRASH"
     misc_feature    14052..14065
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.71"
                     /tool="antismash"
     misc_feature    complement(14212..14227)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 24.02"
                     /tool="antismash"
     gene            14389..16563
                     /locus_tag="LC193_RS28665"
                     /old_locus_tag="LC193_28665"
     CDS             14389..16563
                     /GO_process="GO:0008219 - cell death [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024872.5"
                     /locus_tag="LC193_RS28665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_28665"
                     /product="type II toxin-antitoxin system prevent-host-death
                     family antitoxin"
                     /protein_id="WP_226078318.1"
                     /transl_table=11
                     /translation="MLGLEAARARWSELIDSAAHGGVTHLRDAESGAVARLVPRDRSPV
                     PIEELPAWAVTAARPKLGNLVRQAAAGQPVALTRRGELAAVLAPAPGAAGPATSSGLDD
                     LLDTLTSAAPQAPTTTVPTGIASLDELLGGGLRPGQLALVTGPPGSGMSALALGAARAA
                     ALGAAAPGPVMVASAQMSRQDLAARMLAAEAGLPLAQITTQTVPEADRPRLEAAAARLR
                     GAPLHLVDRQTTLAQVRTAAAAVPGIALLVLDPVTHFDVGTAAPALALRRLATDLGAAV
                     LAVAAHGPGLPPVEAEADLAARLHRQDDGAAARLEIIRYRHGPTAILPLTADLQRARLL
                     PAPAPDHDEPPRPTAPVRSRLATAFQRPAAAPRAESTAARDARAGHRRHQAARRTKSAD
                     QAAQALREMVTAAVEDELDKAQGDAQAAMDRLAKRAIPDVMRLFEQSRAGARYEYTAYP
                     ALPDILHRPSKKDPDLVWEARPSWHHPAYRRHPDGELAVTPLDVNAAYLSALKCHLPIG
                     RLEHDPTGDYDPKRAGVHLITPAAWQHPDLPNPLGDREEPGPLWITTATLRLLLRLAGP
                     KHRLLDPPLIHESWTSSATENFLDALRQVLAAARTDALDQDDYVTLHYIKMMYAKIVST
                     MGESTENRDIMRPDWMHNIRSQAFSNLYGRALKAHRAGLTVISVMGTDELHVAGDWHQV
                     FTQGRGLADMKTKTDRDGRPVHYAVTRVGR"
     gene            16563..17141
                     /locus_tag="LC193_RS28670"
                     /old_locus_tag="LC193_28670"
     CDS             16563..17141
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014152169.1"
                     /locus_tag="LC193_RS28670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_28670"
                     /product="transcriptional regulator"
                     /protein_id="WP_226078320.1"
                     /transl_table=11
                     /translation="MAGRWMRFGFYNAQGVPGRDALGHGIERMVTGIASPPDSERGVAA
                     RLRYLTASPAGYQAMERAGIHVTARTLYAWLAEERLPTPANRARLDDAYWDLRRHNVAA
                     DLKRRLMSHGGTRIEIDPVDQSRVEVRHRRDIQIRHINVRPRVWDTAVDAWLADDEQTM
                     DAIWDDLIRGNLGSEWDAYSYVSSLGWNA"
     gene            complement(17394..18365)
                     /locus_tag="LC193_RS28675"
                     /old_locus_tag="LC193_28675"
     CDS             complement(17394..18365)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0030245 - cellulose catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018844801.1"
                     /locus_tag="LC193_RS28675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_28675"
                     /product="glycoside hydrolase family 6 protein"
                     /protein_id="WP_226078322.1"
                     /transl_table=11
                     /translation="MRTLIRGAVAALLALPLLLASSPSAQAAPDPRAMTSGFYVDPNSN
                     PALWAAGNPSDGRASAIRSSIANTPMARWFGAWSGDIGSATNAYTGAAQSADKLPILVA
                     YNIYGRDACGGHSGGGASSPAEYARWISAFAGGIGSRPAVVVLEPDALGDYSCMTPGQI
                     NERQTMLRNALAEFRSKAPNAWVYLDAGNPGWTDASTMADRLNAAGLGLARGFSLNVSN
                     YFTTSQNAAYAGSINQVLGQRYGYSRPFVVDTSRNGNGSNGQWCNPAGRRIGTPTQQGG
                     GGAEMLLWIKTPGESDGDCGVGSGSTAGQFLPEVAYRMIYGY"
     misc_feature    complement(18493..18507)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 28.15"
                     /tool="antismash"
     misc_feature    18494..18508
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 29.02"
                     /tool="antismash"
     misc_feature    complement(18629..18643)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 27.52"
                     /tool="antismash"
     misc_feature    18630..18644
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 24.69"
                     /tool="antismash"
     gene            18694..19704
                     /locus_tag="LC193_RS28680"
                     /old_locus_tag="LC193_28680"
     CDS             18694..19704
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018840441.1"
                     /locus_tag="LC193_RS28680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_28680"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_226078324.1"
                     /transl_table=11
                     /translation="MTEVPRRQPTLDEVAERAGVSRSAASRVLNNAPHVSRAKRDAVRR
                     AIRELGYVPNPTARALATRQRGVVALVISGESPSIFADPFFARVIVGASAALEEADLYP
                     MLCLAATDRGRQRLEELLRARGADGVIVMAVRENDPVLHIVRETVLPVVFGGRPVGYEP
                     PWYVDADNAGGARQATEHLLARGRRRVAVICGPLDTHVSRERHRGYREAMMLAGLEPCD
                     PVIGDFTEPGGAVAMAELLKRYPEADGVFAANDNMAAGALRTLRGAGRATPRDVAVVGF
                     DDLDIARITEPPLTTVHQPVQALGRESARMLVGLIRGEQPTSLVLPTRLVTRSST"
     gene            complement(20153..21085)
                     /gene="bla"
                     /locus_tag="LC193_RS28685"
                     /old_locus_tag="LC193_28685"
     CDS             complement(20153..21085)
                     /EC_number="3.5.2.6"
                     /GO_function="GO:0008800 - beta-lactamase activity
                     [Evidence IEA]"
                     /GO_process="GO:0030655 - beta-lactam antibiotic catabolic
                     process [Evidence IEA]"
                     /GO_process="GO:0046677 - response to antibiotic [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="bla"
                     /gene_functions="resistance (resist) ClassA"
                     /gene_kind="resistance"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009295990.1"
                     /locus_tag="LC193_RS28685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_28685"
                     /product="class A beta-lactamase"
                     /protein_id="WP_226078339.1"
                     /transl_table=11
                     /translation="MTYTFRMRRGAACAAGLLALVALPACGQEGVGSAPVAAADSARSV
                     PLAEDTAGGLRELEREFDARLGVYALDTGTGREVAYRADDRFAYASTFKALLAGAVLRE
                     HGLEGIDEVIAYSADELVPYSPVTENFVDTGMSLRDLCAATLWYSDNTAANLLLDTLGG
                     PDGLEAVLEEFGDDVTEMDRYETDLNEATPGDIRDTSTPRAMAGSLRAFLLGDALERQE
                     RALLRQWMETNTTGETLIKAGVPEEWTVADKSGSAGYGGRNNVAVVWPDDGGNPIVMAV
                     MSSRDEEDAEHRDALVAEAASVAVEGLGR"
     gene            21409..22338
                     /locus_tag="LC193_RS28690"
                     /old_locus_tag="LC193_28690"
     CDS             21409..22338
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009295998.1"
                     /locus_tag="LC193_RS28690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_28690"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_226078342.1"
                     /transl_table=11
                     /translation="MDLVGACRAFVNVSERGSFTIGAAAARMAQSVASRRIAALEQHLG
                     RRLLERSSRAATLTPFGRDMLPLATQLVRLADQLEHEAEAMRHQPLRIAVPATCPTAAL
                     AHLIADAHSHGIVLDAHPADPAERAELVRLQRVRAALLARPPHDASWTVPLGLAVAEPP
                     HRPSDPAGPEAGPLYLDTLRPGRTDREERPRRVWLQPEDDVPHIRDSLARLRDAVGLRP
                     AQLSVARSVASAVADVLSHGDALLSSPAQAGHLGLRWRPIGELAALARGYTLAVADAAD
                     TDATRLGERCADGIARCLGATADAGVAA"
ORIGIN
        1 aaactcgccc gccccaccga cgacctgctc tccggcctcg ccgcacgcgt cacccgcggc
       61 gaactctccc gccccgaagc ggcccgcatg ggcgtcctgc tgctcatcgc cgggcacgag
      121 accaccgcca acatgatcgc gctgggcacc ctggcgctgc tcaggcaccc ggaccagctc
      181 gcccgcctgc gcgaggcccg cgacccccgc gtcatcgccg gggccgtcga ggagcttctg
      241 cgctacctcc acatcaccca caacggccgc cgtcgcacag cgcttgagga catcgagatc
      301 gccgggtacc gcatccgcgc gggcgagggg ctgatcctgg ccaacgacat cgccaaccgc
      361 gatccgcgcg cgttccccga cgaccccgac cggctcgaca tccgccggga cgcacgccac
      421 cacgtggcct tcggcttcgg cgtccaccag tgcctcggac agccgctcgc gcgactggaa
      481 ctccagatcg tctacggcac cctctaccgc cgcgtcccca ccctgcgact ggcgaccgac
      541 ctcgacgcca tcgccttcaa gcacgacgcg tccgtctacg gcgtccacga actgcccgtc
      601 acctggtgaa ccggccaccc gcggcgggcc ggcagcgcga cggccgccac gcgaaccgcc
      661 ccgaccccgt aggagcgaca tgaacgtgta cctcgaccag gacaaatgcg tcgcctccgg
      721 gcagtgcgtc ctcgccgcgc ccggcatctt cgaccagcgg gaggaggacg gcatcgccgt
      781 gctcctcgac cccgccccac ccgccggccg cgcccgcgac ctccacgacg ccgaagacct
      841 gtgccccgcg ctcgcgatcc gcgtcgacga cgcccaggga acgcccgcca ccggcgaccg
      901 ccccgcctga acccggcagc cgagccgccc ccgccaggcg cccgacgccc ggcggcgcgg
      961 aggacatcac agagaggacc gcgcagtgcc gcaccaggac cggccggcga gccccgcgcc
     1021 ccacgactcc gtggccccgc cgccccccgg cccgctcggc ttcgaccccg acgccctccg
     1081 cgagcgctac cgggccgagc gcgaccggcg catccgcccg gacggcaagc gtcagtaccg
     1141 gagcaccacg ggcgcgttcg gctactacgt cgacgacccc tacaccacgg gcaccccgga
     1201 ccggacaccc cttgaggacc gtatggacgc cgtgatcgtc ggcggcggct tcggcggcct
     1261 gctggccgcc gcccggctgc ggcaggccgg cctgcgggac atccgcgtca tcgacagggc
     1321 cggcgacttc ggcggcacgt ggtactggaa ccgctacccc ggcatccagt gcgacatcga
     1381 gtcctacatc tacctcccgc tgctcgaaga ggtcggctcc atccccgcgt ggaaatacgc
     1441 gccgggggag gacatcaggc agcacgcccg cgcgatcggg cagcacttcg ggctctaccg
     1501 gcacgcctgc ttccagaccg aggtgaccgg cctgcgctgg gacgacacca cggaagaatg
     1561 gctcgtctcg accgaccgcg gcgaccgcgt caccgcccgc tgggtcgtgc tctccggcgg
     1621 gcccttcagc cggcccaagc tgcccggcat ccccggcatc gaggactacc ggggccacac
     1681 gttccacacc agccgctggg actacgccta caccggcggg cacgccggcg gcggcctgga
     1741 cggactcggc gacaagagag tcggcctcat cgggaccggc gccaccgcca tccagtgcgt
     1801 accgcacctc gggcgcgacg cgcggcacct gttcgtcttc cagcgcacgc cctcatcggt
     1861 ggacgtccgc gcgaaccggc gcaccgaccc gggctgggcc cgttccctca ccccggggtg
     1921 gcagcggcgg cggcgcgaca acttcctgct ccacgtcgct ggccggccgg gagccgggga
     1981 cctccccgag gacctggtga acgacgggtg gaccaccagc gcacgccttc tgcgcagcct
     2041 gctgcccggg gacgacacct ccccgcggga ttccgaggag cgccggcgcg cgggcgagct
     2101 cgccgacttc cgcaagatga acgagctccg tgcccgcgtc gacgccgtgg tccacgaccc
     2161 gcacgccgcg gaagcgctca aaccgtggta ccgctacatg tgcaagcgcc ccaccttcag
     2221 cgacacctac ctccagacct tcaaccgcga caacgtgacc ctcgtggaca ccgagggcct
     2281 cggcgtggaa cggatcaccg gcaacgccgt cgtcgtcgcc ggccgcgcct acgaggtcga
     2341 ctgcctgatc ttcgccaccg gcttcgacat cggcgcgcca ccggcggaac gcatcggctt
     2401 ccccgtgcgc ggccgggccg gcaggcgact cgccgagcac tggcaggacg ggccgcgcac
     2461 cctgcacggc atccacagcc acggtttccc gaacctcttc cacctcggat ccctgcacaa
     2521 cgccgtatcg gtcaacttcg tccacgcgct cgacgagcag gcgtcccaca tcgcgcgcgt
     2581 cgtcgccgaa gccgtccggc gcggcgtccg ccgggtcgag ccctcggccg acgcggagcg
     2641 gaagtggggc gacaccatca gggagaccgc gccggacacc caccggttcc tcgccgaatg
     2701 cacacccggg tactacaacg acgagggcat gcccggccgg cgcggcgact cctacggccg
     2761 cggcccgctc gcgttccacg cgctcctgga ggagtggcgc tccggcgacg gcatgggcga
     2821 ggtcatggtc acgtgacggc cgccgccccg cggtcccgcg gggcctgccc gtcccgacga
     2881 tgtcgacgga gcccgccgcg cgggcggcga cggcatcgcc tccctcaccc ggatgcccgc
     2941 ctcccgccgc cacagcacgt acgtacgccg tgccagctgg ccggtccggc gcgggccaag
     3001 ggggagcggg caacgccgcc gctggacgac cacccgcctg gcggtgcggg cgagccgctc
     3061 tcggcgggtg gtccgcccgt tccggttcgg ggcaccggtc aggggaaaga agcccctcac
     3121 cggtaactcc gggccgcgga gccggcacct cccgtgccat cggccgagag aagtcgccgc
     3181 cgcggctgac acaatgggtt cgccccggac gcccgcgcgt gctccgggtg cccgagcttc
     3241 gaccggagcg gagcgcgggc gcagtctgtg aggacgagga gccgccatgg cggacaggcc
     3301 gaatgcgccg gcgaggaccg ccgacgggct cgggctcggc gacgcattgg aacgcgcggc
     3361 cgtcggagtg tgcgccgtcg acgacgcctg gcgcgttctg tgggccaatg accgggcgtt
     3421 ggggcttctg gcccgctccg ccgaggacac cctcggccag gacgtccacg atctcctgca
     3481 ttgcgacgta ccagggcttc cgctcggccg gcacccccgc gagcggtccc gggccctgct
     3541 ccgtcacacc tccaggacgc acccggcccg gtccccgcac ggcggcggca ccccgctgtc
     3601 cctgcaatgc ttcgctctgc cctgcgagcc caacgaccac ggtgtgaccg cgctgatcgc
     3661 cttccaggcc gccgagcccc ccgaggagag cttcgcgccg cccaccgccc cgccgcgcgc
     3721 cctgtcggag aaggaacggc tggccctgct ggccgacacc acggcccagc tgatcgacaa
     3781 cgtcgacgcg cacgagtccc tgcgccgcgt cgtggggctg atgctgcccc ggctcgcgga
     3841 gtgggcggtc atcgacctga tcaccgaggc gaacgaggtc acacgctccc tcgtcgtccg
     3901 cgcccgggcc ggagccctgg aagtccacga ggagctccaa ggccccatgc cgccggtgcc
     3961 ggagacctcc accatgccgc tgtccaaggc cctgcgaggc gcggcgtcca cgctcaccgg
     4021 cccggagacc tacgaggccc cgcccgacag ccgcatcgcg gtggagcagc gcaagctgtt
     4081 ccgggccaca ggcatcgaga ccgccgccat cgcccccatc cgcggccccc gcgaggtgct
     4141 cggcgcactc accctggggc gcaccagccg ccacgaggcc ttcaccacgg gcgacctcgg
     4201 cctccttgag gacatagccc gccgcatcgg catcgccctg gagaacgcgc gccactacca
     4261 gcggcagcgc caggtcgcgg agaccatgca gcgctacctg ctgccccaac tccccgagct
     4321 gcccggcgtg gagatgacca cgcgctacgt atccgccccg gacgcctcgc acgtcggcgg
     4381 cgactggtac gacgccttca ccctccccgg cggcgacgcc gccctgggca tcggcgatgt
     4441 cgtcggccac gacctggaag cggcggcggg catggcccag ttgcgcaaca tgctgcgcgc
     4501 cttcgcgtgg tcccaggacc agcgtccgca ccgcatcgtg gaatgcctcg acgaggccat
     4561 ggcgcacatc tccgacgtgc gcatggcaac gctcatcctc gcccgcctga ccgccgacgc
     4621 cgacggccac tggagactgc ggtgggccag cgccggccac ccgcccccgc tgctcgtcga
     4681 ccacgagggc gccacccgct acctcgacga gggcaacggg cttctcctgg gctcggacat
     4741 ctccgcgccc cgcctcgacg cccacgtcga cctgccgccc ggatcgacgc tcgtgttcta
     4801 caccgacggc ctgatcgaaa cccgcaggca gtccctggac gtcgggctgg aacgcctgcg
     4861 ccggcacgcc gcctcgctgg cccgcaggcc cctggacctc ttcgccgacc agctgctgga
     4921 gcgcacccgc ccggcggaca acgacgacga cgtcgccctg ctcgccatcc gcataccgca
     4981 cgacaccgcg cggacaccgc gaacggtcgc gccgggcccc ggccggtgat gccggtcgcc
     5041 gccgcgtccc gcggccttcc cgcgccggcg cccgaaacac cgtccgctga gccggcgacc
     5101 gcgggggccg cgcccgtcgt cgccgcgggt gcccgggggc gggtccgcgg gctgccggtg
     5161 cccgggcgcc cgttcaggcc gtggcccatg ccgccgccag ggcgacgacg agggcggcca
     5221 ggcccacgat gagccgccgc tggaggcgca gtcgggcccg ggtggcttcc gcggcacggt
     5281 gccgcgcgct ctccgcccgg gcggcggcct gaaggaaggc ccgttcccgt cgcgtcggtt
     5341 cgtggtgctc ccgaccgcac agcgcccggg cctcggccag gtccgcgccc tggtagaggc
     5401 ggccgggcag ccggccgctg tcgtgccagg cacgagccgc ctccgccaac ctgcggtgga
     5461 cgcgccagtc ctccgagccc gtttccgccc accgggccag gcgggtccag gagcggggca
     5521 cggcggtgtg cgaccagacg gcgcggtcgc ggtccagggt gaccacccgg gcacgggcga
     5581 accgttccag cacggcccgg gtcgccgcgt cctcgtccag atccgacagc gcgacagcgc
     5641 gagggccgag tgcggtgggg gcgttcgcgg tggccaggcg cagcaggagg tcgcgggccc
     5701 gggggtgcag ggcgtcgggc aggccggcgt aggcggcctc ggcggaacgg tcgatccagt
     5761 cctcgattcc gcccgcggcg cgcagggcgg tcagggtcag cgcgtgccca ccgcggtgca
     5821 gccaggtctc cttgagcacg gccgacagca tcggaagggc acccggctgt ccggcggtgg
     5881 ccgcggtgag cacggcgaca agggcgtgtt ccggcgcgca gccggcgcgg gcggcgggct
     5941 cggcgatgac ccggtggagt tcctccggcg gtatcgggcc gacgacgagc gggtcgacga
     6001 acagcgcgga ggcggccggc agccggccga ggcagcggtc gtgcagatcg gtgcgcgtgc
     6061 acacgacgat gcggtggtgt ccggcacggg aggtgccggc cgactccagc aggccgagga
     6121 agcgggcacg ttccgcgggt gagcggcagg cggtgatcag ctcctcgaac tggtcgatca
     6181 ccacgaccgt ctcctcgtcg tcggggaagg gaccgtcgcc cagccgggtc agccagcggc
     6241 cggcctcccg catggggcag gggccgggag tgagggtcac cacccgcccc cgatggccct
     6301 cggcccgcag ccgggcgatc agtccggcgt tcagcaggga ggtcttgccg gcgcccgacg
     6361 caccggtgac ggtgaccacg cggcggtggc gcagccgttc ccgcaactcg gtgaccagcg
     6421 cgtcccggcc gaagaaccac ggggagtcgc cgggaccgaa gggcgccgca ccgaggtagg
     6481 gcaccgtgtg ccgatcgccg ggaacggctt ccggaggccg cgggtggccg gcggcggcga
     6541 gtgcggaggc cacgtcgcgc caacggcgtt cccacccgcc gacgtcaccc ccgcaggccc
     6601 cgacgtacgc gagggtcacc gcgagggtgg gcagcctgcg cccgctcgcg gccaccgaga
     6661 gactggcggc cgaggtgtgg gcccgcaggg cgagttgccg atacgtgggg ccgccggcct
     6721 cgtcgcgcag cctgcgcaga tcggcggcga atcgcaggag cggtgtgtcc ccctgctcca
     6781 ggggctgttc ctgacgtggc atcgggaccc ctttcccggc cgctcccgct cgggcggcgg
     6841 cgcgcaggac gtccgacgac gtttcccggg cggtcgcgga cggcatccgc ccgtcccgcg
     6901 gaagacgcag cgtccgcaca cattacgcac ggtgtcgacg caagaacagc gtgaaatccg
     6961 ccatttacgc acgtgttcga cctggtcggc tccgacggga cgatccggcg cgtttgttcc
     7021 gaggttgttc acgcttgttg ttcagccggt ccgacgtgtt cagaacaaca cgatgtccgg
     7081 tagcaatgaa acggcggggc gtcgaacaga acgtcgacca ccgtctgccc ccgagagcgt
     7141 gacctcttcg tcgggagacc cctatgaagt tttctcggta ctgccgctcc ctcctgtcca
     7201 cccccgccac cgcggtgagc cgttacacgc cctgccaccg gtccggcgcc gacatcgcca
     7261 tggtggacct ggaggactcc gtgcctcccg aacgcaagga agaggcccgg cgcctggcgg
     7321 cgcggttctt caccggcccc ggtggcccgg cccgtccggc gatccgcatc aacaccgtcg
     7381 gcgaaccgga cggcctgcgc gacctgctcg cgctgcggca gtaccccgtc aaaccggccc
     7441 tggtcctgat ccccaaggcc gaatcccccc gcgacatcga gatcgtcgaa cacgcactgg
     7501 caccgacctg cccggacacc gagttcttcg ccgtcgtgga gagcccgcgc gggctggcga
     7561 acgcgcccgc catcgccgcg gcctcgccgc gactgcgcgc catggtgttc ggctcggccg
     7621 actactcctt cgccatcggc gcgagcctga gctgggaggc gctcgcctac gccagggcga
     7681 gtctggtgaa cagcgcccgc gcggcgggga tcgaggtcat ggactccccg tacttcgggg
     7741 cgctggacac cgacggcctg cgccgcgagg ccgccgcagc ccgcgacttc ggattcagcg
     7801 ggaaggccgc ggtccatccg cggcagatct ccgtgatcaa cgaggcgttc tcccccgggc
     7861 ccgcgctgct cgaccaggcc aggaaggtgg tggcggcggg ccgggagacc ggcaggggag
     7921 tgacgatggt cgacggcgtc atggtcggtg tgcccttctt cgaggcatcc cagcagctga
     7981 tcgaggagtt cggctagacc ccgagggccc gcgcgccccc gcgcgctgcc cgcccgtgcc
     8041 atcgcaccac cccatgaacc cccaccggtg cactcgtgcg ccctcgacag ggagcttgcg
     8101 accatgcctc agaattcccc gcccgacatc acaggaccgc accgccaccg caacaacgcg
     8161 tcgatgctcc gcgcggcgga ccccgcgtgg caacgggccg ccgacgccgg cctcatcggc
     8221 gtccacgtcg acaccccgga cgcgaacaac cggctcgtcg tccgggagac cgggcacgag
     8281 ttcgtcaaca tgtgctccgt cgggtacctg gggctcaacc accaccccgc gatcatcgag
     8341 ggcgccatcg acgccctcag agaagcgcag gccacctggc tcgtggtgtc cacaacccgc
     8401 atccgccaca acctgctggt gcgcatggag gaggaactgg gcgacctgtt cggcgcgcac
     8461 atcctccccg gcacctcctg cacggcactc accgccggca tcctgcccct cgtggcctcg
     8521 ggccacctca cggacgggca gccccgggtc atggtcttcg accggtactg ccacttctgc
     8581 atggcctacg tcaaacccgt ctgcgccgaa gagaccctgg tcctgacctg cgaccacaac
     8641 gacctcgact acctggagaa gatctgccgc cagtacccga gggtggccta cgtcgccgac
     8701 ggcgcctact ccatgggcgg ggccgcggca ctcgccggcc tgcgcgacct ccaggagcgg
     8761 tacgggctgt tcctgtacat cgacgactcg cactcgctgt ccatcctggg cgagaacggc
     8821 gaggggttcg tccgctcgca actggagatg aacgacctca ccgtcatcgt cgccagcctc
     8881 ggcaaaggct tcggcacggg cggcggcgtg gcgatgctcg gcagccgcac catgttcgaa
     8941 ttcctccacc gccacgccgg gccggtcggc tggtcgcaga acatgtccct ccccctggtc
     9001 ggcgcctcgc tcgccagcgc cgcgatccac cgatccccgg aactgggcga actccagcgc
     9061 cgcctgcgcg agaacatcga ccacttcgac cgcaccttcc cgaccgcgtt cgccggcaat
     9121 gggctccccg tacgccgcat caccgtcgga gaacccgacg acgcggtgcg cctgtccgag
     9181 gaactgttca aacgcggctt ctacagctcc gccgtcttct tccccatcgt cccgcggggc
     9241 gaggcggggc tgcgcatcat gctgcgcgcc gacctcacca cagagctgat cgacgacttc
     9301 accggcaacg tcagggacgt gctgtccacc ttctgaaccg cccgcgcacc ggggcgagcc
     9361 ccctacggac cggccgagag gacacgcaca tgcacgaggc aggcgcagaa ccggcagacc
     9421 gcggcgcggt cccgcccggc caggcgaccg cggaaccggc cccgcccacc ggcttcgaac
     9481 ggatcggcag acagcggtac cgcgaactgg tcgggttcct ctacgaggag ttcacggtgg
     9541 gcgacgtgat cgagcacagg cccggccgca cggtcaccga gatggacaac gtgctgatga
     9601 gcatgctgtc catgaacgac gcccccctcc acatcgacgc cgcctactgc gagaccctgc
     9661 cctggggacg gcccctcgtc tccagcctgg tgacgctcag catcgtcggc gggatgaccg
     9721 cacgcagcac cagcgggcgg gcactggcca acctcggctg ggaccacatc aagctgcccg
     9781 ccccggtgtt cgcgggcgac accctgtacg cgcacagcga gatcctcgcg aaacgacgct
     9841 cccgcagccg ccccggccag ggcatcgtgt cctgccgcac cacggggacc aagtccaccg
     9901 gagaagtcgt gctggtcttc gagcgcagct tcctggtgcc ctgccgcgaa acggccgcgg
     9961 caccgcccgc gaacgccggc gcaccggcgg gggaggggga gtgagaaccc tgctgatcgg
    10021 caacagccgg accgaggaca tggtcggaga tctctcccgc ctgtccgcac gggcacgtga
    10081 ggccgccgca cacacggccc accgcctgct gtggtgggcc agggaggggg acatcctggt
    10141 gctgcccacc gcgccggacg acgcgttcgc ggactacgtg gccggcctca ccggcacccc
    10201 gcgctccacg gtcaccgtgc gcgtgcccgc ccccggcgcc ctcggcgagc acctcctgac
    10261 gccggaccgg ctggccgaca ccgaccttca gcggacgctg gcggaggacc tgggagcacc
    10321 gccgtccggc ggcacacccg gactgcgcgt cctgcccgtc tacgccgacc aggccgtggc
    10381 ccagctcgcg caccgcctgg gcgcggcgcg ggcgctgccc ggccacgcct tccacgccca
    10441 gggaggcagc gccctggtca acagcaaggc ggccttccgg tcggtggccg ccggagccgg
    10501 ggtgccgacc gccccgggca cggtggtcac cgatccaaac gaggcggccc gcgccatcgg
    10561 cgggctgctc ggcgcgggcc actgcgccat ggtcaagcag gagttcagcg gcggcggcct
    10621 ggggaacgag gtgctggcgc ccgtacccgg tgtcgagccg gccggcgccc cccgggccgt
    10681 cgtgctgccc gatgacaccg ccgtgcgcgc ctacgtgacc gagcgctggc cctggctgac
    10741 cgaaggcgga cggcaccggc tggtcgtgga gcgctactac accggcgccg tgccggtgta
    10801 cgcggagttc gacctcaccg acacggcggt cgaactcacc ggcaccggcg agatgctgat
    10861 ggatccggtg gtcgtcggtg agatcgtgcc ggcctccgcc acgctgccgg ccgacgccgt
    10921 ggccgagttg gtcgctgtcg gccggcgctt gtgcgaggcg taccgagcgc tgggctaccg
    10981 gggcacgatc agcgccgacg cgtaccgcac accggaaggc gagatccgct tctgcgaggc
    11041 caacggccgc atcaccggtt ccacccacct gcacaccatc atggccgccc gcctggtggg
    11101 cccggccctg cggccccggc gggtcctcct gggcggtgag tgccccgccc cctccttccg
    11161 cgccgccctc tccgcgctga ccgcagccaa cctgggcttc gacccggcgg ccggcgcggg
    11221 cgtcgtcctg gtcaacgggt ccgccccggg agccgggaca gtcacctact gcgccgtcgc
    11281 cgacgacgcc gcgggcgtcc gggacctgcg gcacgcgctg gaagcggcgc tcgcgagagc
    11341 gcagagctga cccacgcgga tccgcaccgc cggcttccca ccgtaccggg gccgctccgc
    11401 cccgcgaccc gagccgaaag aaggcagaac catgcgcctg aacagctatg acggttggtc
    11461 ccccctgcgc gaggtggtcc tcgggtccgc cgacaactac accgcccacg accgcgagtt
    11521 gtccttcgac ctcttcttcc acgacgaaac gccctacagc cgcatctact atccgcgcca
    11581 cgtgacatcc ggcgcggctc ccggccggcg caccaccatc aagaagcgct acctggagga
    11641 actgcgcgag gacgtcgagg ggatggccga gatcttcgcc caactgggcg tgaccgtcca
    11701 ccggccgctg ccgctcgacg cctcgaccgg cgaggtgcgc acgcccgcct tcgcggcagc
    11761 cgtcgtcccg ccgctcaacg tccgtgacaa cagcatcgtc ttcggggacg agatcatcga
    11821 gaccccgcca ctggtgcgct cgcgctactt cgagacgcag ttcctgaaac cggtctacgc
    11881 cgagtacttc cgccgcggcg cacgctggac ggtcatgccg cgcccgatga tgaccgacgc
    11941 ctcgttcgac ctctcctacg tggcggacgc ggccaagccc ggctccctca tcgaaccgat
    12001 caccgactcg cgaccctccc cgtacgacac cgggttcgag atgatgatcg acggtgccca
    12061 gtgcctgcgg ctgggccggg acgtgttcgt caacgtctcc aacgccaacc acgcgctggg
    12121 ctgcgactgg ctggaacgcc acctgcgcgg gcggttccgc gtgcaccggc tgcaccggct
    12181 ggccgacagc cacatcgaca gcaccgtcct ggcgctgcgg cccgggctgc tgctggtgcg
    12241 cacacccggc gtcgccgagc ggctgccgaa agccctccag agctgggaca tgatcttccc
    12301 gcccgaaccc gaggacaaca acttccccga ctacgaggac gacgacctca tcctcaccag
    12361 ccgctacatc gacctcaacg tgctgtccgt ctcgccggac accgtgctgg tgaacgcggc
    12421 ctgccccgag ctggcccgca cgctggaagg acacgggttc accgtggtcc cggtgcgcca
    12481 ccgccaccgg cggctgttcg gcggcggcct gcactgcttc acgctcgaca cggtgcggga
    12541 gggatccggg cccgaggact acctggactg agaccggccc gcgcggtttt gccgcgggcg
    12601 cgccgcgcga acacacggaa gggacaccgg gcatgggagc gggagcggga gcggggacga
    12661 tgcgggccgt ggtgctgcgg cgcttcggcg ggccgggaca gctgcgcacg gagtcggtgc
    12721 cgcaaccggc cccccgcgag ggggagtcgg tcatcgacgt caccctcgcc gggctcaact
    12781 tcgcggacct ggagatccgg cagggcgcgt acgccccgcc cccgctgccc gccgtcctgg
    12841 gcgtcgatgt ggtcgggcgg cgccgttccg acggacgccg tgtggccgcg ctgctgcggg
    12901 agggaggcgg ctacgcgcag gccgctgtcg cgcgcgacgc ctacacggtg gacgtgcccg
    12961 accacatcga cgacgcccag gcgctcggcc tgctcgaaca gggctgcacc gcgtacggcg
    13021 ccctcgtcac cgccggacgg ctgcggccgg gggagagcgt cgccgtcgcg gctgccgcgg
    13081 ggggcgtggg gcacctcgcg gtgcaactcg cgctcgcgct gggcgcccgt accgtcgccg
    13141 gcatcgcgtc gaccccggcg aaacggcggt tcgtccgctc gctgggcgcg cgggtggcgg
    13201 tcggcgcacc cgagcggctc agtgcggaat tgcccgaggg agtcgacctg tatctcgact
    13261 cggtcggcgg ccccgcgctg cgggcagggc tcgccgcgct ggccccgttc gggcggctgg
    13321 tgaccatcgg cgagcgcgga gcgggaccgg gcagcagcgt gcccgtcgag gagctgacgg
    13381 ggcgttccgt gggcgtgcac gggttctgga tgcggcacgt gctggcggat cccgcgctgt
    13441 tcgcgcgcac cgcggacgcc ctgttcgccc tggcagggcg cgggctggtg cgggcccgcg
    13501 tcgaccgcgt ggtgccgttg gacggagtgg gcgcggccca cgaggcgatg gccgcgcggg
    13561 ccacgctggg caaggtactg gtcgacgtgc gggcatgacg agccgcggat cgtcagtggg
    13621 acgcacggta ggtctggacg atgcccgact cccaggtgac gacgagctgt tcgccatcca
    13681 gggcgacggt ggcccgggta tccggccacc gcatctcacc cgacacgacg cactcgaccg
    13741 tgataacacc ctcgctcacg gtgccctggc agacgtcgcc ctcgacgctc gtgctctcga
    13801 cgaagtggac ctcgtccatg atgaagctga tgttcgtggt gtagggggga tcggcgccct
    13861 ccccgacgag cacccatgcc ccctggatct gctcgttggc cggtgcgccg ccgtccgccc
    13921 cgccctccgg aagccggacc tcgctgccct ccgagtccgg cgtctccggc aggccggaga
    13981 acggaccacc gtcactgtca ccgccacagc ccgccagcac caacgcgacc acagccgtcg
    14041 gcacggccgc ccgtatgccc ttgcgcatgt ctccccctca tcgatcagtc gccgtaggct
    14101 accgccacgg tcgcgggggc gcccgcggca gcacgtacga cgggtccacc cggggcactc
    14161 ggccctcgcc ggcaccggcc gtgcgaagcc tcccaccgcc ggcgcctgta ccgttcgcca
    14221 ccggcgtgcg gacctcgacg gcgggtcggc tgctcacctc ggtttctggc cgccgctcgc
    14281 acgccaagtc ccccgtgcgt ggaacgccag ggcttacgca aggccactag tatgggctga
    14341 cggctcttca ttcatggagg tagggagatg ggcggcggga aggaggatgt gctggggctc
    14401 gaggccgcgc gggcccgctg gtccgaactc atcgactccg cggcgcacgg tggagtgacg
    14461 cacctgcgtg acgcggaatc cggtgccgtc gcgcggttgg taccccggga ccgcagtccc
    14521 gtccccatcg aggaactgcc tgcctgggcg gtgaccgcgg cccgcccgaa actgggcaac
    14581 ctggtccggc aggcggcggc cggccagccg gtcgcactga cccggcgcgg tgaactggcg
    14641 gcggtgctcg cccccgcccc cggggcggcg ggcccggcga cgagcagcgg cctggacgac
    14701 ctgctcgaca ccctcacctc cgccgccccc caggccccca cgacgacggt gccgaccggc
    14761 atcgcatcgc tggacgaact gctcggcggc ggactgcgcc ccggtcaact ggcgctcgtc
    14821 accggcccgc ccggctccgg catgtccgcc ctggccctgg gggcggcgcg cgccgccgcc
    14881 ctgggcgccg cagcacccgg accggtgatg gtcgcctccg cgcagatgtc gcgccaggac
    14941 ctcgccgccc gcatgctcgc cgccgaagcc ggcctgcccc tcgcgcagat caccacccag
    15001 accgttcccg aggccgaccg gccacgcctg gaggccgcgg cggcccgcct gcgaggcgcg
    15061 cccctgcacc tggtcgaccg gcagaccacc ctcgcccagg tccgcaccgc ggccgccgcg
    15121 gtccccggca tcgcgctgct ggtcctcgac cccgtgaccc acttcgatgt cggcacggcc
    15181 gctccggccc tcgccctgcg caggctggcc accgacctgg gggcggcggt cctggcggtg
    15241 gccgcccacg gccccggcct gccccccgtg gaggccgagg ccgacctcgc cgcccgcctg
    15301 caccgccagg acgacggggc cgccgcgcgg ttggagatca tccggtaccg gcacggcccc
    15361 accgccatcc tgccgctcac cgccgacctc caacgcgccc gactcctgcc cgcaccggcc
    15421 cccgaccacg acgagccacc ccgccccacc gcacccgtcc gatcgcgcct cgccaccgcc
    15481 ttccagcggc cggccgccgc gccacgcgcc gaaagcaccg cggcgcgcga cgcccgcgcc
    15541 gggcaccggc gccaccaggc cgcccgccgc accaagtcgg ccgaccaagc cgcccaagcg
    15601 ctgcgggaga tggtcaccgc cgcggtcgag gacgaactcg acaaggccca gggtgacgcc
    15661 caggcggcaa tggacagact ggccaagaga gcgatccccg atgtgatgcg cctcttcgag
    15721 cagagccgcg ccggcgcccg gtacgagtac accgcctacc cggccctccc cgacatcctg
    15781 caccggccca gcaaaaagga ccccgacctc gtctgggaag cccgcccgtc ctggcaccac
    15841 cccgcctacc gccgccaccc cgacggcgaa ctcgccgtca ccccgctcga cgtgaacgcc
    15901 gcctacctct cggcgctcaa atgccacctc ccgatcggcc gcctggaaca cgaccccacc
    15961 ggcgactacg accccaagcg cgcgggagtc cacctcatca ccccggccgc gtggcagcac
    16021 ccggacctgc ccaaccccct cggcgaccgc gaggaacccg gcccgctgtg gatcaccacc
    16081 gccaccctgc gcctcctgct gcgcctggcc ggacccaagc accgactcct cgaccccccg
    16141 ctcatccacg agtcctggac cagctccgcg acggagaact tcctcgacgc cctgcgccag
    16201 gtcctcgccg ccgcacgcac cgacgccctc gaccaggacg actacgtcac actccactac
    16261 atcaagatga tgtacgcgaa gatcgtctcc accatgggcg aatccaccga gaaccgcgac
    16321 atcatgcgcc cggactggat gcacaacatc cgcagccagg cgttctccaa cctctacggc
    16381 cgcgcactga aggcccaccg ggccggcctg accgtgatct ccgtgatggg caccgacgaa
    16441 ctccacgtcg ccggcgactg gcaccaggtg ttcacgcagg ggcgcggcct ggccgacatg
    16501 aagaccaaga ccgaccggga cggccgcccc gtccactacg ccgtcacccg ggtcggccgc
    16561 tgatggccgg ccgctggatg cgtttcggct tctacaacgc ccagggcgtg cccggccgcg
    16621 acgccctggg ccacggcatc gaacgcatgg tgaccggcat cgcctccccg cccgacagcg
    16681 aacgcggcgt cgccgcccgc ctgcgctacc tcaccgcctc acccgccggc taccaggcca
    16741 tggaacgggc cgggatccac gtcaccgccc gcaccctgta cgcctggctc gccgaggaac
    16801 gcctgcccac ccccgccaac cgcgccagac tcgacgacgc ctactgggac ctgcgccgcc
    16861 acaacgtcgc cgcggacctc aaacgccgcc tgatgtcgca cggcgggacc cgcatcgaga
    16921 tcgaccccgt cgaccagtcc cgcgtcgagg tccggcaccg ccgcgacatc cagatccgcc
    16981 acatcaacgt ccgcccccgc gtctgggaca ccgcggtcga cgcctggctc gccgacgacg
    17041 aacagaccat ggacgccatc tgggacgacc tgatccgcgg caacctcgga agcgagtggg
    17101 acgcctactc ctacgtctcc tccctcggct ggaacgcctg aacagcagac cgcacccctg
    17161 cacggctgcc cggccgcggc cggacgtgcg gaccccgaag cgcggtaccg ggcccgggga
    17221 tgcccggacg cgccgacgac gcggcgcacg agggaggtcc ggtggcccag aacgcgcggc
    17281 gccgtgttct gggtgcttcg cgtgctccga ccgcccggct tccggtggac tgccctccac
    17341 cggaagccgg ttcccgtcgg tgacggaggc agtggccggt cggagacgag gcgtcagtag
    17401 ccgtagatca tccggtaggc gacctccggc aggaactgcc ctgccgtgga gcccgagccg
    17461 acgccgcagt ccccgtcgga ctcgcccggc gtcttgatcc acaggagcat ctcggcgcct
    17521 ccgccccctt gctgggtcgg cgtcccgatc ctgcgaccgg cggggttgca ccactggccg
    17581 ttggagccgt tgccgttgcg gctggtgtcc acgacgaacg gccggctgta gccgtaacgc
    17641 tggcccagca cctggttgat gctgccggcg taggccgcgt tctgcgaggt ggtgaagtag
    17701 ttcgagacgt tgagggagaa gcccctggcg aggccgagtc ccgcggcgtt gaggcggtcg
    17761 gccatggtcg aggcgtcggt ccacccgggg ttgcccgcgt cgaggtagac ccaggcgttc
    17821 ggcgccttgg acctgaactc cgccagggcg ttgcggagca tggtctggcg ctcgttgatc
    17881 tggcccggcg tcatgcagct gtagtcgccg agcgcgtcgg gttcgagaac caccacggcc
    17941 ggccggctgc cgatgccacc ggcgaaggcg gagatccacc gcgcgtactc ggccggggac
    18001 gaggctccgc cccctgagtg gccaccgcag gcgtcgcggc cgtagatgtt gtaggcgacg
    18061 aggatcggca gcttgtcggc cgactgcgcc gcgccggtgt aagcgttcgt ggcggagccg
    18121 atgtcgccgc tccaggcacc gaaccagcgg gccatggggg tgttcgcgat ggaggagcgg
    18181 atggcggatg cccgtccgtc actcgggttg ccggccgccc agagggcggg attggagttc
    18241 gggtcgacgt agaagccgct ggtcatggcg cgggggtcgg gtgccgcctg tgcggacggc
    18301 gaggatgcca ggagcagggg cagtgcgagg agcgccgcca ctgctccgcg gatgagtgtg
    18361 cgcatggagg tacctcgtct gtggggatgg aagcgccgcg cggcgttcgt cctgagcccg
    18421 cggcgcaggg gtgcgatgcc accgggccgc ggccttccga gcacgagcgg cgcagggcga
    18481 tcggctgcac ttttgggagc gctcccagat ctgggaggga acgtcccgag gtatcctccg
    18541 tatggtgtgt gagctgatga gggctgtcaa gagaggccgc acacccgtcc acctcccgcc
    18601 ggtgaggcgc tccgtgatcg ccaggaaact ggaagcgctc ccaacgatcg ggagtagcat
    18661 ctcggcaacc ggagcgagaa ggggtgcgca gccatgaccg aggtgccgcg ccggcagccc
    18721 acactcgacg aggtggccga gcgggccggc gtctcccgtt ccgcggcctc ccgggtgctc
    18781 aacaacgcgc cgcacgtcag ccgcgccaaa cgcgacgcgg tccggcgggc catcagggaa
    18841 ctcggctacg tcccgaaccc gacggcgcga gcactggcga cgcgccaaag aggcgtggtc
    18901 gctctcgtca tctcggggga gagcccgtcg atcttcgcgg acccgttctt cgccagggtg
    18961 atcgtcggcg cgtccgccgc cctggaggag gcggacctgt atccgatgct gtgcctcgcg
    19021 gccaccgacc gcggacggca gcgcctggag gaactcctcc gcgcccgggg cgcggacggc
    19081 gtcatcgtca tggcggtgcg ggagaacgac cccgtgctcc acatcgtccg ggagaccgta
    19141 ctgcccgtgg tcttcggcgg gcgcccggtg ggatacgagc cgccgtggta cgtggacgcg
    19201 gacaacgcgg ggggcgcgcg ccaggccacg gagcacctgc tcgcccgcgg aagaaggcga
    19261 gtggccgtga tctgcggccc gctggacacc cacgtgagcc gggagcgcca ccgcggatac
    19321 cgggaggcca tgatgctggc cggccttgag ccctgcgacc cggtcatcgg ggacttcacc
    19381 gagccgggcg gcgccgtggc catggccgag ttgctgaagc ggtacccgga ggcggacggg
    19441 gtgttcgccg ccaacgacaa catggcggcg ggcgcgctgc gcacgctgcg cggcgcgggc
    19501 cgggcgactc cccgcgacgt cgcggtcgtg ggcttcgacg acctggacat cgcgcggatc
    19561 accgaaccgc cgctgacaac ggtccaccag cccgtccaag ccctgggacg cgagtcggcc
    19621 cgcatgctcg tcggactcat ccgcggtgag cagcccacct ccctggtcct gcccacccgc
    19681 ttggtcacgc gctccagcac ctgaccggtc gacgacgtgg agtgccccga gtgcggtcgg
    19741 agaccggtgc ctcaggacgc gggatcaccc gggcgagcgg ccggcccccg gcacgtgtcg
    19801 gcgattgcga acctcaggcc cggctccgcc cgctccctcg gccacgcgcc ggaggcgacc
    19861 ctgccgcgcc cggacctgga tgcccgggaa cgggaacgtg atacgccggc tcgaacgcgt
    19921 tcaccgcttc cgaaccatgg cctcagccgt gacggaacgc gaacgggcca cgctggcccg
    19981 aagtccgctg gggctcggcc cccggtcgga gaaggagtgg cgactggcgg agtcgtcgtt
    20041 caagccaccc ggggcagccc ctcggcaacg cggcccccgc atcaggactc ggaccgcatg
    20101 cgttggctgc cgcgcggaac cgcccccgca cacgatcgcg gcacgaagag acctagcgcc
    20161 ccagcccctc cacggccacg gacgcggcct cggcgacgag cgcgtcgcgg tgttccgcgt
    20221 cctcctcgtc gcggctggac atgaccgcca tgacgatggg gttgcccccg tcgtccggcc
    20281 acaccacggc cacgttgttg cgtccgccgt acccggccga tccgctcttg tcggccacgg
    20341 tccactcctc gggcacgccg gccttgatga gggtctcgcc ggtggtgttg gtctccatcc
    20401 actgccgcag cagtgcgcgt tcctgccgtt ccagcgcatc gcccagcagg aacgcgcgca
    20461 gactgccggc catcgcgcgc ggtgtgctgg tgtcgcggat gtcgccgggg gtggcctcgt
    20521 tcagatccgt ctcgtaacgg tccatctcgg tgacgtcgtc gccgaactcc tccagcaccg
    20581 cctccagccc atcgggcccg ccgagcgtgt cgaggagcag gttggccgct gtgttgtcgc
    20641 tgtaccacag ggtcgccgcg cacaggtcgc gcaggctcat cccggtgtcg acgaagttct
    20701 cggtcacggg ggagtagggg accagctcgt cggcggagta ggcgatcacc tcgtcgatcc
    20761 cctcaagacc gtgctcccgg agcacggcac ccgccagcag cgccttgaaa gtggacgcgt
    20821 acgcgaagcg gtcgtccgcc cggtaggcga cttcccggcc cgtgcccgtg tccagggcgt
    20881 agacaccgag ccgcgcgtcg aactcacgct caagttcccg gaggccgccg gccgtgtcct
    20941 ccgcgagggg cacggaccgc gcggagtccg cggccgcaac gggcgcggac ccgacgccct
    21001 cctggccgca cgccggcagc gcgacgagcg cgagcagacc ggccgcgcac gcggcgcctc
    21061 ggcgcatgcg aaacgtgtac gtcatggtgg tgaacctccg agccgtcgag ggaccgttcc
    21121 gccttccgga tcaaagggat ccggggcgac cccaccaccc tccggcccgc gcgtacctcc
    21181 cgtccaagac acgagcgcgc ggttccatgc cgcttctgca taacggcccc ggagtcgcgg
    21241 gcatcacgcc atccccgaac cgacgcgccc cggccgctcc gcgacgtacg gcaaccgcgg
    21301 aggaccggca tgaagacatc cgcccaagcg gacccggaca ccaccgcccg atgagccggg
    21361 cccgggcgcc gacagacggt ccatgccgct ttggcatact cccctaccgt ggaccttgtc
    21421 ggagcctgcc gcgcgttcgt caacgtgagc gaacgcggca gtttcaccat cggcgccgcg
    21481 gcggcccgga tggcccagtc cgtcgcgagc cgccgcatcg ccgcacttga gcagcatctc
    21541 ggccgacggc tgctcgaacg atcctcgcgc gccgccacgc tcaccccctt cggacgggac
    21601 atgctgcccc tggcgacgca actcgtccgg ctggccgacc aactggaaca cgaggcggag
    21661 gccatgcggc accagccgct gcgcatcgcc gtacccgcca cctgccccac cgccgcgctc
    21721 gctcacctca tcgccgacgc gcacagccac ggcatcgtcc tcgacgccca ccccgccgac
    21781 cccgccgaac gggccgagct ggtccggctc cagcgggtgc gggccgccct gctggcgagg
    21841 ccgccccacg acgcctcctg gaccgttccc ctcggcctgg ccgtcgccga gcctccgcac
    21901 cggccgtcgg acccggccgg acccgaagcc ggcccgctct acctggacac gctgcgcccc
    21961 ggccggaccg accgcgagga acggccgcgc cgcgtctggt tgcagcccga ggacgacgtg
    22021 ccgcacatcc gggacagcct cgcccgcctg cgcgacgccg tcgggttgcg tcctgcccag
    22081 ctgtccgtcg cccgctccgt ggcgtccgcg gtggccgacg tgctcagcca cggcgacgcg
    22141 ttgctctcct cacccgccca ggccgggcac ctcggactgc ggtggcggcc catcggggaa
    22201 ctcgccgccc tcgcccgcgg ttacaccctg gccgtggcgg acgccgcgga caccgacgcc
    22261 acgcgcctcg gcgagcggtg cgcggacgga atcgcccggt gcctcggcgc cacggcggac
    22321 gccggagtgg ccgcgtgaac gacgacaggc tgctgaggga actgcgccac cggctgcgcg
    22381 acggcgggct ccagggctcg gtgctcgtcc gcgacctgaa caccggcgac gagctcggca
    22441 tcgaccccga cgtcgcgttc cccgccgcct cactggtgaa agtgcccctc gcgctcgcca
    22501 cgctggaacg catcaggcgg ggcgaactcg acggcgcggc cgtactcgac gtggccccgg
    22561 gacgggtcac c
//
