LOCUS       NZ_CP084541            22661 bp    DNA     linear   CON 20-NOV-2024
DEFINITION  Streptomyces marincola strain SCSIO 64649 chromosome, complete
            genome.
ACCESSION   NZ_CP084541
VERSION     NZ_CP084541.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces marincola
  ORGANISM  Streptomyces marincola
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 6629020)
  AUTHORS   Shi,S.
  TITLE     Strepomyces indimicinicus sp. nov., an antibiotic producing
            actinomycetes isolated from the marine environment
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6629020)
  AUTHORS   Shi,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2021) Key Laboratory of Tropical Marine
            Bio-resources and Ecology, South China Sea Institute of Oceanology,
            Chinese Academy of Sciences, 164 Xingang West Road, guangzhou,
            Guangdong 510301, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. V6.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 444.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_020410765.1-RS_2024_11_18
            Annotation Date                   :: 11/18/2024 03:45:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,763
            CDSs (total)                      :: 5,689
            Genes (coding)                    :: 5,612
            CDSs (with protein)               :: 5,612
            Genes (RNA)                       :: 74
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 77
            CDSs (without protein)            :: 77
            Pseudo Genes (ambiguous residues) :: 0 of 77
            Pseudo Genes (frameshifted)       :: 21 of 77
            Pseudo Genes (incomplete)         :: 60 of 77
            Pseudo Genes (internal stop)      :: 2 of 77
            Pseudo Genes (multiple problems)  :: 6 of 77
            CRISPR Arrays                     :: 10
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:57:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6278560
            Orig. end                         :: 6301221
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP084541.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22661
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /product="butyrolactone"
                     /region_number="33"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /rules="AfsA"
                     /tool="antismash"
     cand_cluster    1..22661
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /detection_rules="AfsA"
                     /kind="neighbouring"
                     /product="RiPP-like"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..11953
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11953
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6953](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6953)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    326..339
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 17.81"
                     /tool="antismash"
     gene            complement(823..1011)
                     /locus_tag="LC193_RS27765"
                     /old_locus_tag="LC193_27765"
     CDS             complement(823..1011)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LC193_RS27765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LC193_27765"
                     /product="hypothetical protein"
                     /protein_id="WP_226078123.1"
                     /transl_table=11
                     /translation="MAGAIRERRARIGVAVCTGSGLVSMIAYTVSSEPTWVMGALWAWW
                     AALVGATAWYVAMRRDH"
     gene            1140..1400
                     /locus_tag="LC193_RS27770"
                     /old_locus_tag="LC193_27770"
     CDS             1140..1400
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024776.5"
                     /locus_tag="LC193_RS27770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27770"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_226078124.1"
                     /transl_table=11
                     /translation="MSIEEALSRLSEVPESPELTGQEPLPRVLAVAKILQAMAEVDERL
                     RDVRREAILELRRQGMTIRQVAEAVGLSPGRVDQISRNSRV"
     gene            1499..2698
                     /locus_tag="LC193_RS27775"
                     /old_locus_tag="LC193_27775"
     CDS             1499..2698
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016471683.1"
                     /locus_tag="LC193_RS27775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27775"
                     /product="AAA family ATPase"
                     /protein_id="WP_226078125.1"
                     /transl_table=11
                     /translation="MDAQDTRDTAARLRAICDELSERFLERADVVRTLVVTLLAGQHSL
                     LLGPPGTAKSELARELTGRIDGAAYWEILLSKFTAPTRMFGPIDVAALARGEYRQIYEG
                     RATTAHVAFIDEIFKCSTAALNETLGFLNERIYHPESGGEPIRCPLIGAITASNELPAG
                     EDTAAIYDRLLVRIEVGYLADPSNFAALVRSAVDRPVARKRTTVGLAALRHAVTEAVPA
                     VDVPDPVVDAVCTLRAALRRRELVASDRRWRQAVGLLQASAHLDGRRAVAVTDLSVLTH
                     VLWNAPAERPAVEREVLLVVNPDAGEALDLADGIDEVEAQLDAMAGQSREALSEWVIKK
                     AHNKLATAGRRLEELRAEAASAGRSTAAIDRITGRQRAVRARVLTEALGVDASMVQDRL
                     "
     gene            2716..4230
                     /locus_tag="LC193_RS27780"
                     /old_locus_tag="LC193_27780"
     CDS             2716..4230
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010046891.1"
                     /locus_tag="LC193_RS27780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27780"
                     /product="VWA domain-containing protein"
                     /protein_id="WP_226078126.1"
                     /transl_table=11
                     /translation="MSGAPNGPGEPPGMAGPPGAARERHTAAVVADRFDRITWRDTCEQ
                     SAALRELAAELGARHAGAADLMADVFLAAYQARPRLRDFREMAPTRLVNHRIVGSLVAA
                     PHFADLHRETAGDPYAAAMAVLAQAAALRGMLERARTAQEQAAEAAQAAEAAHAAGPTA
                     DAPADRGARQAAEAAARAVAAAAPGLDAAARNAAARAARAVRHEAALMRAWGVGPGDLE
                     RMPFDRRARLAERLGTGRFAQWAELIGRFRQMAVGEHARAVESTAGELVGVTLGDDLSR
                     VIPSELAHLGLPATRAVFAARYAAGELMLYDTTAERPAGRGAVIACVDTSHSMYAAGPG
                     GVTREAWAKACALALLDQARRAGRDFVGILFSSADRTRVFRFPAGAPAGIDGVLDFAET
                     FLGGGTSYQTPLTAARDLLADEFDAAARTRGDIVMITDDECDVTQEWLRDWREAKRRLA
                     FRVFGVSVGAPGATAAGSVLDVLCDNVRSIEDLTDVHAAADLFRVI"
     gene            complement(4337..4987)
                     /locus_tag="LC193_RS27785"
                     /old_locus_tag="LC193_27785"
     CDS             complement(4337..4987)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003958122.1"
                     /locus_tag="LC193_RS27785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27785"
                     /product="DUF5825 family protein"
                     /protein_id="WP_226078127.1"
                     /transl_table=11
                     /translation="MTVSTSPPAVRAWRDYDAHTLDTPGMFLGEVPLSGPTDTLVDRLW
                     DLGARRVELPGRVDLADPGDPEGTVRALGLVRDLTAQAVYTQWRLRLPASAPDWVPFCH
                     LQPPAVLDGVPDAEAALARWRETHYLGKCQWRRGPGFFQLRDRRWGDLRRFTLTDDAYL
                     AAVETLVPGARADDVPAPVLAAFEAEKLAWRVGDRVAWLPYAKRRWTQSAMLI"
     gene            complement(5001..6953)
                     /locus_tag="LC193_RS27790"
                     /old_locus_tag="LC193_27790"
     CDS             complement(5001..6953)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03975"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003958123.1"
                     /locus_tag="LC193_RS27790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27790"
                     /product="RiPP maturation radical SAM C-methyltransferase"
                     /protein_id="WP_226078128.1"
                     /sec_met_domain="TIGR03975 (E-value: 4.8e-174, bitscore:
                     578.4, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLLINMPWSPIDLPSLALGILTRSVNEKVPGARAEVLHGNLDY
                     FDWLTARPGFADFAADDYDYYALSSYFLGCGDWVFSSALYDDPEWRVTEFSEAMRRPVG
                     ARRLAQAVELHRSAPEFVRELAMRVVAQKPDVVGFTSTFQQNTAALAAARMIKELAPGT
                     ITVMGGANCDSAQGEATHRNFPFVDYVVRGEGEVAFPALLNALREGTGLAGITGLCWRD
                     GDVSRANPMATAPLPPAAIVSPDYRGYLDRLAASAARHMIEPKLVIEGARGCWWGEKHH
                     CTFCGLNGSFMQFRSKSPDAFFDEIVGMAREHRVLDMYIVDNILDMGYVTTLLPRLIET
                     GYDLRMHVEIKANMRREQLKTLADAGLVFVQPGIESLNTRVLGLMDKGVSGCQNVRMLR
                     DGASTGLSVSWNYLYGFPEERESDYEPVIAQIPALEHLTPPTGLSARIAIERFSPYFNR
                     PELGFSELRAAKPYWLTYDLPEQELYDLAYIFDAPQRGIGAATAKRLNEALSAWMDANP
                     TSRLVGHDLGERLVLLNRRRAFPWTTLVVDDPLELAAFRLLEQPRSQRTLVRKLGELFP
                     GADAGALVPPLLERWSELGLLFTDAGQYVHVVPAPVNDEMLRLGFMRGVVADAAAPRPD
                     DAARDTDRTPAALPA"
     gene            complement(7018..7140)
                     /locus_tag="LC193_RS29040"
     CDS             complement(7018..7140)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LC193_RS29040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_264086285.1"
                     /transl_table=11
                     /translation="MEKDVIQNDPLEHESEGRSPTVTVSIKVPLMAPEDEDLDV"
     gene            complement(7146..8990)
                     /locus_tag="LC193_RS27795"
                     /old_locus_tag="LC193_27795"
     CDS             complement(7146..8990)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088741.1"
                     /locus_tag="LC193_RS27795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27795"
                     /product="prolyl oligopeptidase family serine peptidase"
                     /protein_id="WP_318842195.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 5.3e-32, bitscore:
                     109.4, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTARAAQPAGERRAYAVSRPVLPAVCRDAPELMAFAGDAEGRCEI
                     FAWHAGTGERRQVTDRPEGTARCAIDPDGVIWWFAERADGTGTWLTQDFAGGADVPAFG
                     GEPARGRPAGLALPGGTAAAGLLDGDRLTVRVGRRGEGPLRTLRFDGQARLAGYAPAAG
                     LLAVARAPGHERAVTLHTVDGGAVAVLSGRGGRIWPLGFAPERGGATAGGAPEPAAGGA
                     ELLLVREDEDGYRLATWTPEGGLRAHAWCAFDTEITAQWVPGGREVLVRQERHGRSLLV
                     LCDLTARTRRAVPVPGGTVLDAAADEGGAVHCLWTDTRTPARVLSTGTAARRLPPPPPE
                     PPPLDAELRDLWTPGEDGPVHTLLALPPGRTGPGPVVFLIHGGPARHDKDAYDPAVHSL
                     VASGLAVARVNYRGSTGYGPRWRAAWGRGVGLTQIEDLAAVRTDLVDRGIADPGATGLW
                     GTSWGGYLVLLALGRQPGLWRAGVAVKPVADYAAAWALGTPELRALDTALFGGTPDEVP
                     GRYARSSPVTYVAGVRAPLLVIAATRDAKCPPEQVRGYLAALRAAGGTCRELWLDSGHD
                     GHDGAGHVRVLRHSLYFLARELRASRAGVSAPRDREGR"
     gene            complement(8987..10267)
                     /locus_tag="LC193_RS27800"
                     /old_locus_tag="LC193_27800"
     CDS             complement(8987..10267)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018569708.1"
                     /locus_tag="LC193_RS27800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27800"
                     /product="MFS transporter"
                     /protein_id="WP_226078129.1"
                     /transl_table=11
                     /translation="MTRAHTEDTNLSRDFRLLWTASAADSLGTQTSGVVLPLLLLAAGH
                     SATVAGAVVSVSLLAGLLAGPFAAVLADRGGRRTVMTWSALTAGAAMAVVALLAVSARP
                     PLGALLAAVTAERVATSAFAAAAQGCVAALVPPAAYPRAVSRLQAGEQGALVAGPVLGG
                     LLFQAARWLPFLADALTYLVAVLCVRSIRGDLSPGAAREPGRRGVGAVFADLRDGLRFV
                     RGESFLRGVLWWMTGVNGVLAALYYGAVFALERQGAGTAAIGTVLAVSGAAGVVGALLA
                     PRLAARIPAARLAVLVSWAVVLVALGLTAATGPWSYGLLFAVVSLLVPTLAVLLAAQAI
                     AVTPAAFQSRVGTVLNTVSGVAATAAPLAAGALVALAGTTGLALAGAGMMALVAVYASR
                     VVAPGLRAAAARPPGAAASPAGREAAP"
     gene            complement(10751..11449)
                     /locus_tag="LC193_RS27805"
                     /old_locus_tag="LC193_27805"
     CDS             complement(10751..11449)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024880.5"
                     /locus_tag="LC193_RS27805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27805"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_226078130.1"
                     /transl_table=11
                     /translation="MPEAAYDEIADWYETEFTAGQRYGAARADPLGLDALARDLLGAGS
                     GPCLEIGCGTGIHAGRVRDLGWTPVGVDLSGGMLRHARGRLPVARADAARLPVRDASVS
                     AVLSVMAHTDMPDYPAVVREAARVLRPGAALTHIGVHPCFCGAFADRRDAEAVVIRPGY
                     GESHWSRESWTDQGVRDKVGASHLPLPALLGAFTAAGLVLERFAEGGGPTPVVFGLRAV
                     RPDDGAVSRP"
     gene            complement(11578..12588)
                     /locus_tag="LC193_RS27810"
                     /old_locus_tag="LC193_27810"
     CDS             complement(11578..12588)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018844045.1"
                     /locus_tag="LC193_RS27810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27810"
                     /product="transcriptional regulator"
                     /protein_id="WP_226078131.1"
                     /transl_table=11
                     /translation="MLRTGLYSVALTVPGRSEIVDRVQAFRGGRLSRIGMGEVAVVTAM
                     TRRIQELDDQFGTRHARPLAANFLVNTAVPYLRADADASVRAALLSATARLCHLAGYMA
                     VDEGLHGLAQRYYVKALEFADAADDRFAYNGTLRGMSVQATDLGHAATALRLADTAAEG
                     AHGAPPPRRAFFAGQQAHAAAQTGDRRTALRHLATAERAMHRADLGGAAFASYDPAALD
                     YHVSQVRWELGDIAGAVASLRASNRGLHVGYQRTTVRRRFMLAERYLRLGHLDVACATW
                     ARALDDYPGIDSGRVDERVAVMKALLRPHRDNGAARAVLARADAPAKAGGAAGVP"
     cand_cluster    11720..22661
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    11720..22661
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[16719:17661](-)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(16720..17661)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="2"
     misc_feature    13132..13145
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.7"
                     /tool="antismash"
     gene            complement(13337..13651)
                     /locus_tag="LC193_RS27815"
                     /old_locus_tag="LC193_27815"
     CDS             complement(13337..13651)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014143049.1"
                     /locus_tag="LC193_RS27815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27815"
                     /product="putative quinol monooxygenase"
                     /protein_id="WP_226078132.1"
                     /transl_table=11
                     /translation="MFGLMVRFTCKDEEAAAAFDELVAQTGAQIRANEPGTVIYTVHRV
                     DGQPLQRIFYELYRDVDAFETHESQDYVRRFLDERNQYLSATEVDRLDLMSGKGVDVEH
                     "
     gene            13877..14503
                     /locus_tag="LC193_RS27820"
                     /old_locus_tag="LC193_27820"
     CDS             13877..14503
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1116:
                     Homoserine/threonine efflux protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018838877.1"
                     /locus_tag="LC193_RS27820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27820"
                     /product="LysE family translocator"
                     /protein_id="WP_226078133.1"
                     /transl_table=11
                     /translation="MVDSSLYAAFLVAALALCVTPGPDMMFIVAMGGRGGPAVGVMAAL
                     GVAGAMCVHAVAATLGLSALFTALPALYHVLRWAGAAYLLYLAVKAFRDRGPLGSGEGS
                     AGPGYRRAFWQGAVINLLNPKVILFNVAFLPQFVDPGRGQVPAQLLTLGITIVVIGLCV
                     DGTVGLLSGRLALLLRRSRRVARGLNIFSGTVFTGLAIRLVASPR"
     gene            14753..16642
                     /locus_tag="LC193_RS27825"
                     /old_locus_tag="LC193_27825"
     CDS             14753..16642
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF027688.5"
                     /locus_tag="LC193_RS27825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27825"
                     /product="calcineurin-like phosphoesterase family protein"
                     /protein_id="WP_226078134.1"
                     /transl_table=11
                     /translation="MVSFPAREHSSLRIALTALTTLAVAGGLVAIPTASTATPGPAPAS
                     WDENAYRGQVEVVRTPEGPADPEHLTGRVFVDRDRDSVGDRGERGLPGVVVSNGRDVVT
                     TDRHGRYRLPVYDNMTVFITQPSGYQVPVDESNVAQFHWNHLPEGSPELRYGGIAPTGP
                     LPDAVNFPLVRSQLTRAQEQHCVIAGDLQTYDRTEVEYARRGAINDLAGRRDYQGCGTL
                     FIGDVVGDDLSLYPDVKELTSRINGPARFLPGNHDLDFDSTTAEHAFDTFRAQLAPAYY
                     SYDVGDVHVVALNTVRYPCTPDVDNADGLRPQCDDPENSPRYNGRLDEHQLAWLERDLA
                     AVDEDKLVVLAGHIPLLTFADEGSPIHQVDQVREIYALLEGREAVSVAGHTHSIENMRT
                     GDLMRGWQDLFGVEGLPFPHITAGAISGDWYSGELTEHGYPAAVGRDGGRPGLLTLDIR
                     GDSFRERYTVTGESDRVQTQLGINSPTYRDWYAERQAWNDDPQGPAPELGDPHVVTRAD
                     LAGQTWLTTNFWMGSTGSTVEVRIDGGRSREAVRTQPMRGEDQLIGPEWSDPHAVAQQL
                     VHGGSVADRTMHLWRLELPADLDAGRHRAEVTATDVHGREYTDVLHFRVVEQP"
     gene            complement(16720..17661)
                     /locus_tag="LC193_RS27830"
                     /old_locus_tag="LC193_27830"
     CDS             complement(16720..17661)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014047021.1"
                     /locus_tag="LC193_RS27830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27830"
                     /product="ScbA/BarX family gamma-butyrolactone biosynthesis
                     protein"
                     /protein_id="WP_226078135.1"
                     /sec_met_domain="AfsA (E-value: 5.4e-16, bitscore: 56.8,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHLHLTREDNVLVTGYARLGPHTFLLSGRWPRDDAVAADDPRVL
                     THAVRQSGLAVAHAEYGVPLHHQTLLHSLDFSFAPAPRAAGRPAAPLLIEADVLGAPRP
                     GRTLRSLAMAVRLVRDGAAVVEARARFGWVSPAVYRRLRGDRVTPAGTWGAGPVPAPAA
                     PGAVGRARRENVVLAPGPGPRVWRLRADVTDTLLFDHPVDHVPGLVLVEAALQAAHAHA
                     PGLGIRTVACDYERFAELDAPCWIVSRAERPPRPDGRTVIEVDGTQGGRPVFRVAVGGT
                     LPVAGAAAPPPATRNGAPVPLAARDVAACALP"
     misc_feature    complement(17618..17633)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.53"
                     /tool="antismash"
     gene            17869..18516
                     /locus_tag="LC193_RS27835"
                     /old_locus_tag="LC193_27835"
     CDS             17869..18516
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003991562.1"
                     /locus_tag="LC193_RS27835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27835"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_226078136.1"
                     /transl_table=11
                     /translation="MARQDRAIRTRRICLEAAAEIFDECGYEGASIAAILERAGLTRGA
                     LYFHFSSKEELARGVLAEAVTAEGVMPQPLKLQEWVDTALLLAHRLPREPVLSASIRLS
                     ADPRARGLLGTRWPDWIALGRDLIAEAKARGEVMPHVDPLVASRVTVASWTGVQLVSGS
                     QPDAPALVDDIVALFALLLPGIAVPAVLARLEVSADRPARLLAQVRAAVPAD"
     gene            18643..18990
                     /locus_tag="LC193_RS27840"
                     /old_locus_tag="LC193_27840"
     CDS             18643..18990
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007389900.1"
                     /locus_tag="LC193_RS27840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27840"
                     /product="plasmid stabilization protein"
                     /protein_id="WP_226078137.1"
                     /transl_table=11
                     /translation="MPKGSTSKQERQYEHIKEGAKKRGASAGRAKEIAARTVNKERARS
                     GQAASASRSSTRGDSPSRRGGKASGGGRAQGSGAKGGTATRDELYEQAKRRDIKGRSSM
                     TKQQLAKALGR"
     misc_feature    complement(19042..19057)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.69"
                     /tool="antismash"
     misc_feature    complement(19056..19071)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.23"
                     /tool="antismash"
     gene            19086..19649
                     /locus_tag="LC193_RS27845"
                     /old_locus_tag="LC193_27845"
     CDS             19086..19649
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004992911.1"
                     /locus_tag="LC193_RS27845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27845"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_226078138.1"
                     /transl_table=11
                     /translation="MPRSPAALRGQIRASALRLFAEHGFRATSLQDIASDAGCSKASLL
                     YHFANKDAILSELLAPVGERTAALLAGLDALTGERKARAAVSGLVDLALGHSAEFRLLF
                     EDLPRLVADPGMHPVPDAAERLLGALAAGSPGPRARAAAGLVLGGIVMSAFGDGADRGE
                     DMRAGLVEAALRALGLAPDPPPGT"
     gene            19706..21880
                     /locus_tag="LC193_RS27850"
                     /old_locus_tag="LC193_27850"
     CDS             19706..21880
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035: MMPL domain-containing transport protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009074929.1"
                     /locus_tag="LC193_RS27850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27850"
                     /product="MMPL family transporter"
                     /protein_id="WP_226078139.1"
                     /transl_table=11
                     /translation="MATLLYRLGRISFRRRGRVLALWLLMLALLGGAAASFSGTMSDDF
                     TMPGTEAQEAMDLLERDFPQASGAGGTVVVAAPEGETLDQAALAPLVREAAEVPGVAAA
                     MDPFTTGAVSPDGRYALIQVQFDAAAQDLSEAQTEAFEQVGADAEGLRVEHGGEAVTAH
                     AGPHASAAEVVGVLVAAVVLVITFGSLVAAGMTLLNALIGVGVGMAGLYALSGAVELSA
                     TAPILALMLGLAVGIDYSLFITSRYRQYLSEGVPAEEAAGRATGTAGSAVVFAGATVVI
                     ALCGLSVVGIPFLTVMGLAAAATVAVAVLVALTLLPAILGFAGPRVLSRKERSGRSTGQ
                     PGREGAGFAWGRLVTRLRVPVLLAGVVGLGALTLPAQDMRLALPDASTAAEDTPQRQAY
                     DLTAEGFGPGFNGRLVAVVTAGSPEGTASAAQEAEALISGTDGVVAVTPPQPNEQGTTA
                     LLNVTPATGPSDAATEDLVHDIRERVAGIDGADVALTGTTAVGIDVSEKLSDALPVYLL
                     LVVGLSVLLLMLVFRSVLVPLKAAAGFLLTVGATFGITVAVFQQGHLADLVGLDTTGPL
                     VSFLPILLIGILFGLAMDYEVFLVSRMREDYVHGDTPSQATINGLGHNGRVVAAAAVIM
                     TAVFAGFVLTDDPIIKSIGFALALGVVIDAFIVRMTLVPAAMSLLGRAAWWLPRPLDRA
                     LPNLDIEGERLRHRLAGEHEEQERREHAGT"
     gene            complement(21943..>22107)
                     /locus_tag="LC193_RS27855"
                     /old_locus_tag="LC193_27855"
                     /pseudo=""
     CDS             complement(21943..>22107)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003959911.1"
                     /locus_tag="LC193_RS27855"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27855"
                     /product="two-component system response regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="PGDLSAAECAAASGLSRVSARRYLEYWASTGRARVSLRYGATGRP
                     ERRFHWSGG"
ORIGIN
        1 tggccggcgc cctgctcgcg ccgctcaacc cggccgcgcg cgaccggctg gtcgccgcca
       61 tggccgaggt cgaacggctg ctgaccgccg cgaccgtccg cgtcgaggcc gtcgaccccg
      121 gtcaccccga cgccgcgcac tgcctgcgtt cctatgccgc cgagctggcg gaacgcttcg
      181 acaccggctt cgacccggcc ctgagcctgc tgcccgacgc gggagaactc aagccgccgc
      241 gcggcctgtt cctcgtcgcc aggctgaacg gggaacccgt gggctgcgcc ggtctcaggc
      301 tgccggccgg ggctccggcc gagatcaaac gcatgtgggt cgcaccgggc agccggggcc
      361 tcggcctggc gcgccgcctc gtcgccgagc ttgaggcggc ggccgtccgc cacggtcacg
      421 acctgctgcg cctcgacacg aacagggccc tggacgcggc cgtcgccctc taccgcgcct
      481 gcggcttccg cgaggtgccc gcgttcaacg acgagcgcta cgcccaccac tggttcgaga
      541 agcggatcgg gccgaaggcc gcggaatgac gtgccgaagt cgggtcgagg cgcggtggaa
      601 acggaaagcg gcctgcctcg ccgggcggcc cgaaagggat actcgggtac cggggaacaa
      661 cggggaaaag cagggaatgc gagggaatgc gagggaatgc gaggaagagg ggaaagcgat
      721 gggaggcgag agagtgccga acgcggcggc cgagtcgcgt atccgggaaa tcctgccgtg
      781 cctcccggcg acctcgtcgc gataaacgcg aaagagcccg gttcagtggt cacgtcgcat
      841 ggcgacgtac cacgcggtgg cgccgaccag cgccgcccac caggcccaca gcgcccccat
      901 gacccaggtc ggttctgagg agaccgtgta ggcgatcatg ctcaccaggc cggaacccgt
      961 gcacacggcc acaccgattc tcgcgcgccg ctcccgtatc gctccggcca tgcccccact
     1021 ccttttctgt tgccggtccc ttcggctccg gaagggggac gagctgagac ggtagggaac
     1081 acgagccggg cgcgtcaagc gagttggaca ggcttatggc gcgtggctag ggtgggccca
     1141 tgagcattga ggaagcgctg tcccgtctga gcgaggtccc ggaatccccc gagctgaccg
     1201 gacaggagcc gcttccgcga gtgctcgccg tcgcgaagat cctccaggcc atggccgagg
     1261 tcgacgaacg cctgcgggac gtgcgacgcg aggccatcct ggaattgcgc cgccagggca
     1321 tgacgatccg ccaggtcgcc gaggcggtcg gcctcagccc tggccgagtc gaccagatct
     1381 ccaggaactc acgcgtctag gctcttcgtt cggatcttcg tggatacggc cgctccccca
     1441 ggcccctggg ggcctgggag gcgtcccagg atgcggtgcg tcgcgaggcg gagggatcat
     1501 ggacgcacag gacacgcggg acacggcggc gcgactgcgg gcgatctgcg acgagttgtc
     1561 ggaacgcttc cttgagcgtg ccgacgtcgt gcggaccctc gtggtgacgc tgctcgcggg
     1621 gcagcactcg ctgctgctcg gcccgccggg caccgcgaag tcggagctgg ccagggagct
     1681 gaccggccgg atcgacggcg cggcctactg ggagatactg ctgtccaagt tcaccgcgcc
     1741 gacccgcatg ttcgggccca tcgacgtcgc cgcgctggcc cggggcgagt accgccagat
     1801 ctacgagggc cgcgccacga ccgcgcacgt cgcgttcatc gacgagatct tcaagtgctc
     1861 gacggcggcg ctgaacgaga ccctcggctt cctcaacgag cggatctacc acccggagag
     1921 cggcggcgag ccgatccgct gccccttgat cggcgccatc acggcgagca acgagctgcc
     1981 ggccggcgag gacacggccg cgatctacga ccgcctgctg gtacggatcg aggtcggcta
     2041 cctcgcggac ccgtcgaact tcgcggcgct ggtgcgctcc gcggtcgacc gcccggtggc
     2101 gcggaagcgg accacggtcg gactggccgc gctgcgacac gccgtgaccg aagccgttcc
     2161 cgccgttgac gtccccgacc cggtcgtgga cgcggtgtgc accctgcgcg ccgccctgcg
     2221 ccgcagggaa ctcgtcgcct ccgaccgccg ctggcggcag gcggtcggcc tgctccaggc
     2281 gtccgcccat ctcgacggcc gccgggccgt cgccgtgacc gacctgtccg tgctgacgca
     2341 cgtgctgtgg aacgcgccgg ccgaacggcc ggccgtggag cgcgaggtgc tgctcgtggt
     2401 gaaccccgac gcgggggagg cgctcgacct ggccgacggc atcgatgagg tggaggccca
     2461 gctcgacgcg atggcagggc agtcccgcga ggcgctgagc gagtgggtca tcaagaaggc
     2521 gcacaacaag ctggccaccg cgggccggcg gcttgaggaa ctgcgcgcgg aggcggcgag
     2581 cgccggccgt tccaccgccg ccatcgaccg gatcaccggc cgccagcggg ccgtccgggc
     2641 ccgcgtgctc accgaagcgc tgggcgtgga cgcgagcatg gtgcaggacc ggctctgagg
     2701 cggcgggagc cggagatgag cggggcaccg aacggacctg gcgagccgcc gggcatggcc
     2761 ggcccgcccg gcgccgcccg cgagcggcac accgcggccg tggtcgcgga ccggttcgac
     2821 cggatcacct ggcgcgacac gtgcgagcag tcggccgcgc tgcgcgaact cgccgcggaa
     2881 ctcggcgcgc gccacgccgg ggcggccgat ctgatggccg acgtgttcct cgccgcctac
     2941 caggcccgcc cgcggctgcg cgactttcgg gagatggctc ccacccggct ggtcaaccac
     3001 cggatcgtcg gctcgctcgt ggcggcgccg cacttcgcgg acctgcaccg ggagacggcg
     3061 ggtgacccgt acgccgccgc catggccgtg ctcgcccagg ccgccgcgct gcgcggcatg
     3121 ctggagcgtg ccaggaccgc ccaggaacag gccgccgagg ccgcccaagc agccgaggcc
     3181 gcccacgccg ccgggcccac ggcggacgct cccgccgacc ggggcgcccg acaggccgcc
     3241 gaggccgccg cgcgcgccgt cgccgccgcg gcccccggcc ttgacgccgc cgcgcggaac
     3301 gcggcggcgc gggccgcccg ggccgtgcgc cacgaggccg cgctgatgcg ggcgtggggg
     3361 gtcggccccg gcgacctcga acggatgccg ttcgaccggc gggccaggct cgccgagcgg
     3421 ctgggcacgg gccggttcgc gcagtgggcc gaactcatcg gccgcttccg gcagatggcc
     3481 gtcggcgagc acgcccgcgc ggtggagagc accgcgggtg aactggtcgg cgtcacgctc
     3541 ggcgacgacc tctcccgcgt catcccttcc gagctggccc acctcggact gcccgcgacg
     3601 cgcgcggtgt tcgccgcgcg ctacgccgcc ggggagctga tgctctacga caccacggcg
     3661 gaacggcccg ccggccgggg ggccgtcatc gcctgcgtgg acacctcgca ctccatgtac
     3721 gcggccgggc ccggcggtgt cacccgggag gcgtgggcga aggcgtgcgc gctggcgctg
     3781 ctcgaccagg cccgccgtgc cgggcgtgac ttcgtcggca tcctgttctc ctccgccgac
     3841 cggacgcggg tcttccgttt cccggccggc gcgcccgccg gcatcgacgg ggtcctcgac
     3901 ttcgccgaga ccttcctcgg cgggggcacc agctaccaga ccccgctgac ggcggcccgc
     3961 gacctgctgg cggacgagtt cgatgccgcc gcccgcacgc gcggcgacat cgtgatgatc
     4021 accgacgacg agtgcgacgt cacccaggag tggctgcgcg actggcggga ggccaagcgc
     4081 cggctggcgt tccgggtctt cggcgtgtcc gtcggcgccc ccggcgccac cgcggcgggg
     4141 tcggtcctcg acgtcctgtg cgacaacgtg cgttccatcg aggacctcac cgacgtgcac
     4201 gccgccgccg acctgttccg cgtgatctga cccggcggga ggaccgcgcc tcccgtggcg
     4261 tccggccggg tccggcggcc ccccgtcgcc gtcggacccg gccggcccgc cggccctcac
     4321 gccaccgccg ccgccctcag atgagcatgg cggactgcgt ccagcggcgc ttggcgtagg
     4381 gcagccaggc gacccggtcg ccgacgcgcc aggccagctt ctcggcctcg aacgccgcca
     4441 gcaccggcgc gggtacatcg tccgcccgcg cgccgggcac gagcgtttcg acggccgcga
     4501 ggtacgcgtc gtccgtcagg gtgaaccgtc gcaggtcgcc ccacctgcgg tcgcgcagct
     4561 ggaagaagcc gggccctcgc ctccactggc acttgcccag gtagtgggtc tcgcgccacc
     4621 gggcgagcgc cgcttcggca tccggtacgc cgtcgagcac ggcgggtggc tggaggtggc
     4681 agaacggcac ccagtccggc gccgaggcgg gcagccgcag ccgccactgc gtgtagacgg
     4741 cctgcgcggt caggtccctg accagtccga gggcgcgcac cgtgccctcc gggtcgcccg
     4801 ggtcggcgag atcgacgcgt cccggcagct cgacccggcg ggcgcccaga tcccacagcc
     4861 ggtcgacgag cgtgtccgtc ggcccggaca gcggtacctc gcccaggaac atgccgggcg
     4921 tgtccagcgt gtgggcgtcg tagtcgcgcc aggccctgac ggccggaggc gaagtgctca
     4981 cggtcatcac tcctcgaagg tcaggccgga agcgcggcgg gcgtccggtc ggtgtcccgg
     5041 gcggcgtcgt ccggccgcgg ggcggcggcg tcggccacca cgccgcgcat gaagcccagg
     5101 cgcagcatct cgtcgttgac gggcgcgggc accacgtgca cgtactgacc ggcgtcggtg
     5161 aacagcagcc cgagttccga ccagcgctca aggagcggcg gcaccagcgc cccggcgtcc
     5221 gcgccgggga acagctcacc gagcttgcgg accagcgtcc gctgcgaccg aggctgttcg
     5281 agcagccgga acgcggccag ctccagcgga tcgtcgacga ccagggtcgt ccaggggaag
     5341 gcgcggcggc ggttcaggag caccaggcgc tccccgaggt cgtgtcccac caggcggctg
     5401 gtggggttgg cgtccatcca cgcgctcagc gcctcgttca gccgcttcgc cgtcgccgcg
     5461 ccgatgccgc gctggggtgc gtcgaagatg taggccaggt cgtacagctc ctgctccggc
     5521 aggtcgtagg tcagccagta cggcttggcg gcgcgcagct cgctgaaacc gagctccggc
     5581 cggttgaagt aggggctgaa cctctcgatc gcgatgcgcg cggacagccc ggtcggcggg
     5641 gtgaggtgtt cgagcgcggg gatctgggcg atcaccggct cgtagtccga ttcgcgttcc
     5701 tccgggaagc cgtagaggta gttccacgac accgagaggc ccgtgctggc cccgtcgcgc
     5761 agcatgcgca cgttctggca gccgctgacg cccttgtcca tcaggccgag cacacgggtg
     5821 ttgaggctct cgatgcccgg ctgcacgaag accaggcccg cgtccgcgag cgtcttcagc
     5881 tgttcgcggc gcatgttcgc cttgatctcc acgtgcatcc gcaggtcgta gccggtctcg
     5941 atgagccggg gcagcaacgt ggtcacgtag cccatgtcga ggatgttgtc gacgatgtac
     6001 atgtccagta cccggtgctc gcgggccatg ccgacgatct cgtcgaagaa cgcgtccggc
     6061 gacttgctgc ggaactgcat gaacgagccg ttgaggccgc agaacgtgca gtggtgcttc
     6121 tcgccccacc agcagccgcg ggcgccctcg atcaccagct tcggctcgat catgtgccgg
     6181 gccgccgagg cggccagccg gtccaggtag ccgcggtagt cgggcgagac gatcgccgcc
     6241 ggcggcaggg gagccgtcgc catcgggttg gcccgggaga catcgccgtc gcgccagcac
     6301 agaccggtga tcccggcgag gccggtgccc tcgcgcagtg cgttcaggag ggcggggaac
     6361 gccacttcgc cctcgccgcg gacgacgtag tcgacgaacg ggaagttgcg gtgcgtggcc
     6421 tcgccctgcg cgctgtcgca gttcgcgccg cccatgacgg tgatcgtccc gggtgccagc
     6481 tccttgatca tgcgggcggc ggcgagcgcg gcggtgttct gctggaacgt cgaggtgaac
     6541 ccgaccacgt cgggcttctg cgcgaccacg cgcatcgcca actcgcgcac gaactccggc
     6601 gcgctccggt gcagttcgac ggcctgggcc agccgtcgcg caccgacggg ccggcgcatc
     6661 gcctcgctga actcggtgac ccgccactcg gggtcgtcgt acagcgccga ggagaaaacc
     6721 cagtcgccgc agccgaggaa gtaggaggac agggcgtagt agtcgtagtc gtccgcggcg
     6781 aagtcggcga agccgggcct ggccgtcagc cagtcgaagt agtcgagatt gccgtgcagc
     6841 acctcggccc gcgcgccggg caccttctcg ttcacgctgc gcgtgaggat gccaagggcc
     6901 agggacggca ggtcgatcgg ggaccacggc atgttgatca gaagcacccg cacggctgct
     6961 ccctcctggt atccgtaagg ggcggccggc ccgggggccg ggccggccgc gggtgggtca
     7021 gacgtcgagg tcctcgtcct ccggcgccat cagcggcacc ttgatggaca cggtgacggt
     7081 cggcgaacgg ccttcggact cgtgctccaa cgggtcgttc tgaatcacgt ccttctccac
     7141 gggaatcacc tcccttctcg gtctcgtggt gcggaaaccc cggcccggga ggcgcgcaac
     7201 tcccgggcca ggaagtacag gctgtgccgc agcacgcgca cgtgcccggc accgtcgtgg
     7261 ccgtcgtgcc cggagtccag ccacagctcg cggcacgtgc cgccggccgc gcgcagcgcc
     7321 gcgaggtagc cgcgcacctg ctcgggcggg cacttggcgt cccgcgtcgc ggcgatcacc
     7381 agcaggggcg cccggacacc ggccacgtac gtcacgggcg aggaacgcgc gtaacggccg
     7441 ggcacctcgt cgggcgtgcc gccgaacaac gcggtgtcca gcgcgcgcag ttcgggcgtg
     7501 ccgagcgccc acgcggcggc gtagtcggcc accggcttga ccgcgacgcc cgcgcgccac
     7561 aggccgggct ggcgcccgag ggcgagaagc accagatatc cgccccagga cgtgccccac
     7621 aggccggtcg cgccgggatc ggcgatgccc cggtccacca ggtcggtgcg gacggcggcc
     7681 aggtcctcga tctgcgtcag cccgacgccc cggccccacg cggcgcgcca gcggggcccg
     7741 tagccggtgg agccgcggta gttgacccgg gccaccgcga gccccgaggc cacgagcgag
     7801 tgcacggccg ggtcgtaggc gtccttgtcg tgccgcgccg ggcccccgtg gatgaggaac
     7861 accacgggcc cggggccggt gcggccgggc ggcagcgcga gcagcgtgtg cacggggccg
     7921 tcctcgcccg gggtccacag gtcgcgcagc tcggcatcga gcggcggcgg ctcggggggc
     7981 ggcgggggga gccggcgggc cgccgttccg gtggacagca cccgcgcggg cgtgcgggtg
     8041 tcggtccaca ggcagtgcac cgcgcccccc tcgtcggccg ccgcgtcgag caccgtcccc
     8101 ccgggcacag gcaccgcgcg gcgggtgcgc gcggtgaggt cgcacaggac cagcaggctg
     8161 cgcccgtgcc gctcctggcg caccagcacc tcgcgcccgc ccggcaccca ctgggcggtg
     8221 atctcggtgt cgaacgcgca ccacgcgtgc gcccgcagcc cgccctccgg ggtccaggtc
     8281 gccagccggt agccgtcctc gtcctcgcgc accagcagca actccgcgcc gccggcagcc
     8341 ggttccggcg cgccgccggc cgttgccccg ccgcgttccg gcgcgaaacc gagcggccag
     8401 atccggccgc cgcgtcccga cagcaccgcg accgcgccgc cgtccaccgt gtgcagggtg
     8461 accgcccgtt cgtgcccggg cgcgcgggcc accgcgagga gcccggcggc cggagcgtag
     8521 ccggccagcc gcgcctggcc gtcgaaccgc agcgtgcgca gcggcccttc gccgcgccgg
     8581 ccgacgcgca cggtgagccg gtcgccgtcg aggaggccgg cggcggccgt accgccgggc
     8641 agcgcgagcc ccgcgggccg accccgagcc ggttccccgc cgaacgccgg gacgtccgcg
     8701 cccccggcga agtcctgggt cagccacgtc ccggtgccgt cggcccgctc ggcgaaccac
     8761 cagatcacgc cgtccggatc gatcgcgcac cgcgcggtgc cctcgggccg gtcggtgacc
     8821 tgcctgcgct cgccggtgcc cgcgtgccac gcgaagatct cgcaccgacc ttccgcgtcc
     8881 ccggcgaacg ccatcagctc gggcgcgtcc cggcagacgg cgggcagcac gggccgcgac
     8941 acggcgtacg cgcgccgttc cccggcgggc tgtgccgcgc gggccgtcac ggcgcggcct
     9001 cccgtcccgc gggggaggcc gccgcgccgg gcggacgggc cgccgccgcg cgcagtcctg
     9061 gcgccaccac gcgggaggcg tacaccgcga ccagggccat catgcccgcg cccgcgaggg
     9121 cgagccccgt ggtcccggcc agcgccacca gggcgccggc cgccagggga gcggccgtcg
     9181 cggcgacgcc ggagacggtg ttcagcaccg tgccgacccg ggactggaac gcggccgggg
     9241 tgacggcgat ggcctgcgcg gccagcagca ccgcgagggt cgggacgagc agggagacga
     9301 ccgcgaacag caggccgtag gaccagggcc cggtggcggc cgtcaggccc agggccacga
     9361 gaacgacggc ccaggacacc agtaccgcca gccgcgcggc gggaatccgc gccgcgagcc
     9421 gcggggcgag cagcgcgccg accacgccgg ccgcccctga gacggcgagc accgtgccga
     9481 tggccgcggt gccggcgccc tgccgctcca gcgcgaacac ggcaccgtag tacagagcgg
     9541 ccagcacccc gttgacgccc gtcatccacc acagcacgcc ccgcaggaac gattccccgc
     9601 ggacgaagcg cagcccgtcg cgcaggtcgg cgaacaccgc gccgacgccg cgccgccccg
     9661 gttccctcgc cgcgccgggc gagaggtcgc cacgtatcga acgcacgcac aggacggcga
     9721 ccaggtaggt cagggcgtcg gcgaggaacg gcagccagcg cgccgcctgg aacagcagcc
     9781 cgccgagcac gggccccgcc accagcgccc cctgctcgcc ggcctggagc cgggacaccg
     9841 cccgcgggta ggcggcgggc ggcaccaggg ccgccacgca gccctgggcg gcggcggcaa
     9901 aggcggaggt ggcgacccgt tcggccgtga ccgccgcgag cagcgccccg agcggcggac
     9961 gcgcggagac ggcgaggagc gcgaccacgg ccatggcggc cccggccgtc agcgcggacc
    10021 aggtcatcac ggtgcgccgt ccgccgcgat cggccagcac cgcggcgaag gggccggcga
    10081 gcagcccggc caggagcgac accgagacga cggcgccggc gacggtcgcc gaatgccccg
    10141 cggcgagcag cagcagcggc aggacgacac cggaggtctg ggtgccgagg gagtcggcgg
    10201 cggaggcggt ccacagcagc ctgaagtcac gtgaaagatt cgtgtcctcg gtgtgtgcgc
    10261 gggtcatgcc acctccctcg ctctccctgg tgccgggggg acggacgata ggagggcgcg
    10321 gggagtgcca caagaacgcg cgtagagccg ccaccgggcc gccgcggggt gtgtgcggaa
    10381 gtgagggagg atttgcgaac gggcctccca ccgggggatg acgccaggtg cgcggcggcg
    10441 ggccggcggc ccgggccgtt tgccgtgacg gaacagcggc gcgcggcccg cgcgttggcg
    10501 cgttctccca gcttcgttca ctgctccggt ggcgcgcggg gcgcgtgtgg cgccccggga
    10561 cgggtgggtg ggcgggggcg cgggggtgtc cgtttcgtac ccgcccggtg aagaaccgat
    10621 tgttcgccgc ggcgaaaagg cccccgaatg ccgaaccggc ggccgattcc gtcgccttga
    10681 ccgaaaaccg ccgccggaac gctgtgttcc ggccgcgcgg ccgactaccc agccgcggcc
    10741 ggtggccgcg tcaggggcgc gaaaccgccc cgtcgtccgg ccggaccgcg cgcagcccga
    10801 acaccacggg cgtcggaccg ccgccctccg cgaaccgttc gaggaccaga ccggccgcgg
    10861 tgaacgcgcc gagcagggcg ggcagcggca ggtgcgaggc gccgaccttg tcgcgcacgc
    10921 cctggtccgt ccaggactcg cgactccagt ggctctcgcc gtagccgggc ctgatcacga
    10981 cggcctccgc gtcgcgccgg tcggcgaacg cgccgcagaa gcacgggtgc acgccgatgt
    11041 gcgtcagggc ggcccccggc cgcaggacac gcgccgcctc ccgcaccacg gccgggtagt
    11101 cgggcatgtc ggtgtgcgcc atcaccgaga gcaccgcgga cacggaggcg tcccgcaccg
    11161 gcagccgcgc cgcgtccgcg cgcgcgacgg gcagccggcc gcgcgcgtgg cgcagcatac
    11221 cgccggacag atcgacacca acgggcgtcc agcccaggtc gcgcacgcgc ccggcgtgga
    11281 ttccggtgcc gcagccgatc tccaggcaag gacccgagcc cgcgccgagg aggtcgcgtg
    11341 ccaaggcgtc cagaccgagc gggtccgcgc gcgcggcgcc gtaccgctgt cctgcggtga
    11401 actccgtctc gtaccagtcg gcgatctcgt cataggccgc ttccggcatc gtgccccgcc
    11461 tcccgtagcc gtcgtccccg aaccgtcgct acccgcacgc gcgaggcggc tcccgccgtt
    11521 ccgccccggg cgaaccattc ccggcggcac gccgacccga agggcccgcg acgcgggtca
    11581 gggaacgccg gccgccccac ctgccttggc gggcgcgtcg gctcgtgcga ggacggcacg
    11641 agcggcaccg ttgtcccggt gcggccggag cagcgccttc atgacggcga cccgttcgtc
    11701 cacgcggccc gagtcgatcc ccgggtaatc gtccagcgcg cgtgcccagg tggcgcaggc
    11761 gacgtccaga tgccccagcc gcaggtaccg ttccgccagc atgaaccggc ggcggaccgt
    11821 ggtgcgctgg tatccgacat gcagtcccct gttcgacgcg cgcaacgacg ccaccgcacc
    11881 cgcgatgtca ccgagttccc acctcacctg gctgacgtgg tagtccaggg ccgccgggtc
    11941 gtaggacgcg aacgccgcgc cccccaggtc ggcgcgatgc atggcgcgtt ctgccgtggc
    12001 caggtgcctc agcgccgtcc gccggtcgcc cgtctgcgcg gcggcgtgcg cctgctgccc
    12061 cgcgaagaac gcccgcctgg gcggcggggc gccgtgggcc ccttccgctg ccgtgtcggc
    12121 gagccgcagg gccgtggcgg cgtgcccgag atcggtcgcc tgcacgctca tcccgcgcag
    12181 ggttccgttg taggcgaagc ggtcgtccgc cgcgtcggcg aactccagcg ccttcacgta
    12241 gtagcgctga gcgagtccgt gcaacccctc gtcgacggcc atgtagccgg ccaggtggca
    12301 caggcgggcc gttgcggaga gcagcgcggc gcgcacgctc gcgtcggcgt ccgcccgcag
    12361 gtagggaacg gcggtgttca ccaggaagtt ggccgccagc gggcgtgcgt ggcgggtgcc
    12421 gaactgatcg tcgagttcct gaatccgccg ggtcatggcg gtgaccacgg cgacctcgcc
    12481 catgccgatc ctcgacaggc gtccgccgcg gaacgcctgc acgcggtcga cgatctccga
    12541 ccgtcctggc acggtcagcg cgacggagta gaggccggta cgcagcaccc cacggcgggc
    12601 gggtccatgt cgctcctcgc tagttcctcc aactcttcga cggtattgcc cgcttgattg
    12661 ttcggatgcc cggaaagcgg cgggagaccg gcttcgccgg gtgcaacagg acgctgcccg
    12721 gggatcttcg atgccaggtg tccgcgagtc cccgcccggc ggatgtcgcg caactccggg
    12781 ccgtacaccg gtaccacatg gaggagtgtg agacgtgcgg ccttggtgcg ccgtgtgaga
    12841 tgggcaacct gcttcatctc gcatgcgagg aggctgcacg ccgctgcgcg tccccatcac
    12901 aggccggggt gccgtgaccg gcgttgtcgc ggagtccgac acgcgcggtc ggtcggcgtt
    12961 gtacggccat gtcaacgggc ccggcgtact cccacaggag tcgctcgccg gatgtccggc
    13021 gcggcggcgg ccacatcatc gtccaagtgt tctcgtcccc ggagtgcaat cgtcatgaga
    13081 cctcaccccg cgcatcgccc aaccacctcg ccaggtgctt ccgtgctggt gtcgatcgag
    13141 atcgatgtcc gtaccgtgcg gcgcggcgac caattgctga tgggggccaa gcattcacgg
    13201 tcggcgacat gaccgcgctg ggcgccgggc gcaagcggct cgtgttcacc agcggtgaga
    13261 tcttcacgat gaaccccgcc accgtgttgt gggccgcgcg tctcgtggac ccccggatac
    13321 gccgctgaac tcgtactcag tgctcaacgt ccacgccctt gccggacatg aggtccaggc
    13381 ggtcgacttc ggtcgcggac aggtactggt tccgctcgtc gaggaagcgg cgcacgtagt
    13441 cctgcgactc gtgcgtctcg aacgcgtcga cgtcccggta cagctcgtag aagatccgct
    13501 ggagcggctg gccgtcaaca cggtggaccg tgtagatcac cgtgcccggt tcgttcgcac
    13561 ggatctgtgc tccggtctgc gccaccagct cgtcgaacgc ggcagccgcc tcctcgtcct
    13621 tgcaggtgaa gcgcaccatc agtccgaaca tggcaattcc tctctcctcg gcggtctcgg
    13681 gctggcactc ccacggcgca cgctatgcgg ccatcgagcc gcaccaaaag tgcgttgccg
    13741 tactctcgac gctggccgac atgggctgcc atgtccacgg gcccgccgct ccgcgcggga
    13801 gggtccgcca ccccgcccgt cccacgcagc ggaaatccgg tcgccgcgcg ggggcagggc
    13861 ggcgaggatg ccccgcatgg tggattcatc gttgtacgcg gcttttctcg tggccgccct
    13921 cgcgctctgc gtcacgccgg gccccgacat gatgttcatc gtggcgatgg gcgggcgggg
    13981 cggccccgcg gtgggcgtga tggccgcgct cggcgtggcc ggcgccatgt gcgtgcacgc
    14041 ggtggccgcg accctggggc tctccgccct gttcacggcc ctgccggcgc tctaccacgt
    14101 gctgcgctgg gccggcgcgg cctacctgct gtacctggcg gtcaaggcgt tccgcgaccg
    14161 cggacccctc gggagcgggg aggggagcgc cgggcccggg taccggcgcg ccttctggca
    14221 gggggccgtc atcaacctgc tcaacccgaa ggtgatcctc ttcaacgtcg ccttcctgcc
    14281 gcagttcgtc gacccgggcc gggggcaggt gccggcgcag ctgctgacgc tggggatcac
    14341 gatcgtggtc atcggactgt gcgtcgacgg aacggtcggc ctgctctcgg ggcggctcgc
    14401 cctgctgctg cgccgcagcc gccgtgtcgc gcgcgggctc aacatcttca gcggaacggt
    14461 gttcacgggg ctggcgatac ggctggtggc ctccccgcgg tagccggccg tgagccctcg
    14521 gctggccggc cgcaagccct cggcggtgag gcgtgtcgtc ggccgcggcg gacgggacgt
    14581 cacgggagcg cgggacatca cacgttcgcc acacgttcgc gcgcggggtg gcgccggtac
    14641 ggctgctgtt cttccgttga gcgtgccgcg ttcaggctcg tgacgaagga tcgtcgccgc
    14701 ggccggccga ccgcgccggt accgcgcccc cacgacaacc ggagaaccgc acatggtgag
    14761 tttccccgcg cgagaacaca gcagcctccg tatcgccctg accgcgctca cgaccctggc
    14821 ggtcgcgggc gggctcgtgg cgatccccac cgcctccacc gcgacgccgg gcccggcacc
    14881 cgcgtcctgg gacgagaacg cctaccgcgg ccaggtcgag gtcgtgcgca cccccgaggg
    14941 ccccgccgac cccgagcacc tgaccggcag ggtcttcgtc gatcgggacc gcgacagcgt
    15001 cggcgaccgc ggggagcgcg gcctgccggg cgtcgtcgtg tcgaacgggc gcgacgtcgt
    15061 gacgaccgac cgccacggcc gctaccggct gcccgtgtac gacaacatga cggtcttcat
    15121 cacccagccg tccggctacc aggtgccggt ggacgagtcg aacgtcgccc agttccactg
    15181 gaaccacctg cccgagggct cgcccgagct gcgctacggc ggcatcgcgc cgaccgggcc
    15241 cctgccggac gcggtcaact ttccgctcgt gcgcagccag ttgacccggg cgcaggagca
    15301 gcactgcgtc atcgccggcg acttgcagac ctacgaccgc accgaggtcg agtacgcgcg
    15361 ccggggcgcg atcaacgacc tcgcgggccg tcgcgactac cagggctgcg gcacgctgtt
    15421 catcggcgat gtcgtcgggg acgacctgtc gctctacccg gacgtcaagg aactcaccag
    15481 ccgcatcaac ggcccggcca ggttcctccc gggcaaccac gacctcgact tcgactccac
    15541 caccgccgag cacgcgttcg acaccttccg cgcgcagctc gcgcccgcct actactccta
    15601 cgacgtcggt gacgtgcacg tcgtcgcgct gaacaccgtg cgctacccct gcaccccgga
    15661 cgtcgacaac gccgacggcc tgcgcccgca gtgcgacgac ccggagaaca gtccgcgcta
    15721 caacggccgg ctcgacgagc accagctcgc ctggctcgaa cgggacctgg ccgcggtcga
    15781 cgaggacaag ctcgtcgtgc tcgccggcca catcccgctg ctgaccttcg ccgacgaggg
    15841 cagccccatc caccaggtcg accaggtccg cgagatctac gcgctgctcg aaggccgcga
    15901 ggccgtctcc gtcgccgggc acacccactc gatcgagaac atgcgcaccg gcgacctcat
    15961 gcgcggctgg caggacctct tcggcgtcga ggggctgccg ttcccgcaca tcacggcggg
    16021 cgcgatctcc ggtgactggt actcgggcga gctgaccgag cacggctacc ccgcggcggt
    16081 cgggcgcgac ggcggccggc ccggcctgct cacgctcgac atcaggggcg actcgttccg
    16141 ggagcggtac acggtgaccg gcgagagcga ccgggtgcag acgcagctcg gcatcaacag
    16201 tcccacctac cgcgactggt acgccgagcg ccaggcgtgg aacgacgacc cccagggccc
    16261 cgcgcccgaa ctgggcgacc cgcacgtggt gacgcgcgcg gacctggccg ggcagacctg
    16321 gctgaccacc aacttctgga tgggctcgac cggttcgacg gtcgaggtgc ggatcgacgg
    16381 cggtcgttcc cgcgaggccg tccgcaccca gccgatgcgc ggcgaggacc agttgatcgg
    16441 ccccgagtgg tccgatccgc acgccgtcgc ccagcagctg gtgcacggcg gcagcgtcgc
    16501 cgaccggacc atgcacctgt ggcgcctcga actgcccgcc gacctcgacg cgggacggca
    16561 ccgcgccgag gtgaccgcga cggacgtcca cggccgcgag tacaccgacg tgctgcactt
    16621 ccgcgtcgtc gaacagccgt agcgccaccg cgccttcggg ccgccgccgc gaacgggtgg
    16681 cggcccgggg ccgcacggtt caggcggccc cggcgcggtt cagggcagcg cgcacgcggc
    16741 gacgtcgcgc gccgcgaggg gcaccggcgc gccgttccgg gtggcgggcg gcggcgccgc
    16801 ggcccccgcg accggcagcg tgccgcccac cgcgacgcgg aacaccggac gaccgccctg
    16861 cgttccgtcg acctcgatca ccgtccgccc gtcggggcgg ggcgggcgct cggcccggct
    16921 cacgatccag cagggcgcgt cgagttcggc gaaccgctcg tagtcgcagg cgacggtgcg
    16981 gataccgagc ccgggtgcgt gcgcgtgcgc ggcctggagc gcggcctcca cgaggacgag
    17041 cccaggaacg tggtccacgg ggtggtcgaa cagcagcgtg tcggtcacgt cggcccgcaa
    17101 ccgccagacg cgcgggccgg gtcccggggc gagcacgacg ttctcgcggc gcgcgcggcc
    17161 gacggcccct ggggcggccg gcgcgggcac cggcccggcg ccccaggtcc cggccggggt
    17221 cacgcggtca ccgcgcaggc gccggtagac ggcgggggag acccagccga agcgggcccg
    17281 cgcctccacc acggccgcgc cgtcccgcac gagcctgacc gccatggcca gcgacctcag
    17341 cgtccggccg ggccgcggcg ccccgagcac gtccgcctcg atcagcaggg gggcggccgg
    17401 gcggccggcc gcgcgcggcg ccggggcgaa ggagaagtcg agcgagtgca gcagggtctg
    17461 gtggtgcagg ggaacgccgt actcggcgtg ggcgacggcg agcccgctct gccggaccgc
    17521 atgcgtgagg accctcggat cgtcggccgc gaccgcgtcg tcacgcggcc accgcccgga
    17581 cagcaggaac gtgtggggcc cgaggcgcgc gtacccggtg acaagaacgt tgtcctcgcg
    17641 cgtgagatgc aggtgctcca tcggcaccgc cctcgtcacc ggggcggggc cgtgcggctc
    17701 gggtcttcgc cggggcgccg gtggagagga cgacgcgcgc agggctaacg gggcctgatc
    17761 cacgacgagt tccccccagg acaatccgga cggcgaagcg gcactgataa gataccggtt
    17821 ctccggtatt gtgcaaggag caggtaaaac gggccagggg ggacccagtt ggcgagacag
    17881 gacagggcca tccgcacgcg gcggatctgc ctggaggcag ccgccgagat cttcgacgag
    17941 tgcggttacg agggcgcgtc catcgccgcg atcctggagc gggcggggct gacgcgcggc
    18001 gccctgtact tccacttctc ctccaaggag gagctggcgc gcggcgtgct cgccgaggcc
    18061 gtgaccgccg agggggtcat gccgcagccg ctgaagttgc aggagtgggt ggacaccgcg
    18121 ctgctgctcg cgcaccgcct gcccagggag cccgtgctca gcgcctccat ccggctgtcc
    18181 gccgatccga gggcgcgcgg cctgctcggc acccggtggc ccgactggat agcgctgggg
    18241 cgcgacctga tcgccgaggc gaaggccagg ggcgaggtca tgccgcatgt cgacccgctg
    18301 gtcgcctccc gggtgacggt cgcctcctgg accggtgtcc agctggtcag cggctcgcag
    18361 cccgacgcgc ccgcgctggt cgacgacatc gtcgcgctgt tcgcgctgct cctgcccggt
    18421 atcgcggtgc ccgcggtcct cgccaggctt gaggtgtcgg ccgaccggcc ggcgcggctg
    18481 ctcgcgcagg tcagggcggc cgttcccgcc gactgaccgg tcgcgccgcc ttccggcctg
    18541 ccgggccgtt tcccgccccc ggtcgccggg cacccggccg gaacgcgccg tccgcgggcg
    18601 gccggaacga caaggcgcag gaccagcgag ggagtcgtgg cgatgcccaa gggatcgacc
    18661 tccaagcagg agcgtcagta cgaacacatc aaggagggcg ccaagaagcg cggcgcctcc
    18721 gcggggcgcg ccaaggagat cgccgcccgg acggtgaaca aggagcgcgc gcgctcggga
    18781 caggcggcct cggccagccg ctcatccacc cgcggcgact cgccctcccg gcgcggcggc
    18841 aaggcgtcgg gcggcgggcg cgcgcagggc agcggcgcga aggggggaac ggcgacgcgc
    18901 gacgagctgt acgagcaggc caagcggcgc gacatcaagg gccgctcctc catgaccaaa
    18961 cagcagctgg ccaaggcgct cggccgctga cgcgcgtcca cgggtcgcgc cgcccggcga
    19021 ccggtgtcgc cgggcggcgg gcgtgagcca gttcactgac cgatcggtca gttacggtgg
    19081 ggggcatgcc ccgctctccc gccgcgctgc gcggccagat ccgagcctcc gcgctgcggc
    19141 tgttcgccga gcacggcttc cgggccacct cgctccagga catcgcgtcc gacgcgggct
    19201 gctcgaaggc gtcgctgctc taccacttcg cgaacaagga cgcgatcctc tccgagctgc
    19261 tcgcccccgt cggggagcgc acggccgcgc tcctggccgg tctcgacgcg ctgacgggcg
    19321 agcgcaaggc gcgggcggcc gtgtccggcc tggtggatct cgcactgggc cacagcgccg
    19381 agttccggct gctgttcgag gacctgccgc ggctggtcgc cgacccgggc atgcacccgg
    19441 tgcccgacgc ggcggaacgc ctgctcggcg ccctggccgc cggttccccc gggccgcgcg
    19501 cacgggccgc ggccgggctc gtcctcggcg gcatcgtcat gtccgcgttc ggcgacggag
    19561 ccgaccgcgg cgaggacatg agggcgggcc tggtcgaggc cgcgctgcgc gcgctcggcc
    19621 tcgcgcccga cccgcccccc ggcacctgac cgcgggcgcc acggccccca ccccccagcg
    19681 cactaccgaa ggacgacccc acaccatggc taccctgctg taccggctcg gccggatatc
    19741 cttccgccgc cgcgggcgcg tgctcgccct gtggctgctc atgctcgccc tgctcggcgg
    19801 cgcggcggcg agcttcagcg gcacgatgtc ggacgacttc acgatgccgg gcaccgaggc
    19861 ccaggaggcc atggacctgc tggaacgcga cttcccgcag gcgtcgggag ccgggggcac
    19921 ggtcgtcgtc gcggcgcctg agggcgagac gctcgaccag gccgcgctcg ccccgctcgt
    19981 ccgggaggcg gccgaggtgc ccggggtcgc cgccgccatg gacccgttca ccaccggcgc
    20041 cgtctcgccc gacggcaggt acgccctgat ccaggtgcag ttcgacgccg cggcgcagga
    20101 cctgtcggag gcgcagacgg aggccttcga gcaggtcggc gcggacgccg aggggctgcg
    20161 cgtcgagcac ggcggcgagg ccgtgaccgc gcacgcgggg ccgcacgcct ctgccgccga
    20221 agtggtcggc gtcctcgtgg cggcggtcgt gctggtcatc acgttcggct cgctggtcgc
    20281 ggccggcatg accctgctca acgcgctcat cggcgtcggc gtcggcatgg ccggtctcta
    20341 cgcgctcagc ggtgcggtgg aactgagcgc caccgcgccc atcctggccc tgatgctggg
    20401 cctggccgtc ggtatcgact actccctgtt catcacctcc cgctaccgcc agtacctctc
    20461 cgagggcgtg ccggccgagg aggccgcggg gcgggccacc ggcaccgcgg gctccgccgt
    20521 cgtgttcgcc ggcgccaccg tggtgatcgc cctgtgcggt ctgtcggtgg tcggtatccc
    20581 gttcctcacc gtgatgggcc tggccgccgc cgcgaccgtc gccgtcgcgg tgctcgtggc
    20641 cctgacgctg ctgcccgcca tcctcggctt cgccgggccg cgggtcctct cccgcaagga
    20701 gcggtccggc cggtccaccg ggcagccggg acgcgagggc gccggcttcg cgtggggccg
    20761 gctggtcacg cggctgcgcg tgccggtgct gctggccggc gtcgtcgggc tcggggcgct
    20821 caccctgccc gcgcaggaca tgcggctggc cctgcccgac gcctcgaccg cggccgagga
    20881 caccccgcag cggcaggcgt acgacctgac cgccgagggc ttcgggcccg ggttcaacgg
    20941 gcgcctggtc gccgtcgtca ccgccggttc accggagggg acggcatcgg cggcgcagga
    21001 ggccgaggcg ctgatctccg gcaccgacgg cgtcgtggcc gtgacgccgc cgcagcccaa
    21061 cgagcagggc accacggccc tgctgaacgt cacgcccgcc accggcccgt cggacgccgc
    21121 gaccgaggac ctggtccacg acatccgcga acgcgtcgcc ggcatcgacg gcgccgacgt
    21181 ggccctgacc ggcaccacgg ctgtgggcat cgacgtctcg gagaagctgt ccgacgccct
    21241 gcccgtctac ctcctcctgg tcgtcggcct ctcggtcctg ctgctgatgc tcgtcttccg
    21301 ttccgtcctg gtgcctctca aggcggcggc cggcttcctg ctgaccgtcg gcgcgacgtt
    21361 cggcatcacc gtcgccgtgt tccagcaggg ccacctggcc gacctcgtgg gcctcgacac
    21421 cacggggccg ctggtgagct tcctgccgat cctcctgatc ggcatcctct tcggcctggc
    21481 catggactac gaggtcttcc tcgtctcccg catgcgcgag gactacgtgc acggcgacac
    21541 gccgagccag gccacgatca acggcctcgg ccacaacggc cgggtggtgg ccgccgccgc
    21601 ggtcatcatg acggcggtct tcgccgggtt cgtcctgacc gacgacccca tcatcaagtc
    21661 catcggcttc gcgctcgcgc tcggcgtggt catcgacgcg ttcatcgtcc gcatgaccct
    21721 ggtgccggcc gcgatgtccc tgctcggccg ggccgcctgg tggctgcccc gccccctgga
    21781 ccgcgcgctg cccaacctgg acatcgaggg cgaacggctg cggcaccggc tcgccggcga
    21841 gcacgaggag caggaacgcc gggagcacgc cggcacctga gccgccgcgc ccggggcggg
    21901 cccgcccggc cccgggcgcg cgaacggtcc gcgcgcccct gctcagccgc ccgaccagtg
    21961 gaagcggcgc tcgggccggc cggtcgcgcc gtagcgcagc gacaccctgg cccggcccgt
    22021 cgaggcccag tactccaggt acctgcgggc gctgacccgg gacagcccgc tggccgccgc
    22081 gcactcggcg gcggacaggt cgcccggcag cgctgaaaag gacccgacgg acgcccgtcg
    22141 ggtccttttc agcggaagac agctgaactg gccgaccagc gcgcctggtc atgccgtggt
    22201 cgcgtgcgcg agccgggtga gcgcggcctt gatgcggtcg gtcgtcaccc cctgggcgcg
    22261 ctggtggagg aagagctcgg gcgcgagggg cgcgagcacg acatccgcga gggcttcggg
    22321 atcaggggcg ccggcctggc gaagaagcgc gagaacgtga gcgcgccaga agccgtaggc
    22381 gccgaccgtg tagcgcttgg ctccgacctc ggctccgagg gcgaggtggc tgtgccggtc
    22441 cagcaggtcg accatggccg agaggaaggc ggcgagtcgc tcgtggggcg gcgctccggg
    22501 gcccagcggc ggggcgccgc gcaacagctc gccctggagc agtcgttcat gttcgtcgag
    22561 cagcgccgcc gcgatggatg acacgtccgg gtagcggcgg tagagggtgc cccgtccgac
    22621 gccggcggcg cgggcgatgt cctccatcgt gaccatgcgg g
//
