LOCUS       NZ_CP084541            22511 bp    DNA     linear   CON 20-NOV-2024
DEFINITION  Streptomyces marincola strain SCSIO 64649 chromosome, complete
            genome.
ACCESSION   NZ_CP084541
VERSION     NZ_CP084541.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces marincola
  ORGANISM  Streptomyces marincola
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 6629020)
  AUTHORS   Shi,S.
  TITLE     Strepomyces indimicinicus sp. nov., an antibiotic producing
            actinomycetes isolated from the marine environment
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6629020)
  AUTHORS   Shi,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2021) Key Laboratory of Tropical Marine
            Bio-resources and Ecology, South China Sea Institute of Oceanology,
            Chinese Academy of Sciences, 164 Xingang West Road, guangzhou,
            Guangdong 510301, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. V6.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 444.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_020410765.1-RS_2024_11_18
            Annotation Date                   :: 11/18/2024 03:45:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,763
            CDSs (total)                      :: 5,689
            Genes (coding)                    :: 5,612
            CDSs (with protein)               :: 5,612
            Genes (RNA)                       :: 74
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 77
            CDSs (without protein)            :: 77
            Pseudo Genes (ambiguous residues) :: 0 of 77
            Pseudo Genes (frameshifted)       :: 21 of 77
            Pseudo Genes (incomplete)         :: 60 of 77
            Pseudo Genes (internal stop)      :: 2 of 77
            Pseudo Genes (multiple problems)  :: 6 of 77
            CRISPR Arrays                     :: 10
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:57:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6240091
            Orig. end                         :: 6262602
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP084541.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22511
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="32"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22511
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22511
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12511](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12511)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            complement(598..1602)
                     /locus_tag="LC193_RS27565"
                     /old_locus_tag="LC193_27565"
     CDS             complement(598..1602)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014181368.1"
                     /locus_tag="LC193_RS27565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27565"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_226078086.1"
                     /transl_table=11
                     /translation="MRRHRPRPAARRRLPALASWLAVALALTACAGPGADGGGGPAPAG
                     AAGEGTGVHLGPDQDRIGTERVDAVAALLPEEIRDRGTLEVAHSPGSAPPLTFYATDDE
                     TVIGVETDIASLVGDVLGLEVRYHTVDWANLFVGLDSGRYDVGFSNITVTEERKDKYDF
                     ATYRLDNVAFEARAGGDWRVEGARDVAGRTIGVSSGTNQEELLVSWSEQNVADGLDATD
                     IKYFQNATDYYLALSSGRIDAYFGPNPVAAYHAAVTGETEIIGSFSGAGAEIQGEIAAT
                     TKKDNGLVRALNEALNTVIDNGTYGQVLDRWGLADEAVEVSEVNPPGLPRAEE"
     gene            complement(1721..2494)
                     /locus_tag="LC193_RS27570"
                     /old_locus_tag="LC193_27570"
     CDS             complement(1721..2494)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006382195.1"
                     /locus_tag="LC193_RS27570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27570"
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="WP_318842194.1"
                     /transl_table=11
                     /translation="MSGGRRTMVDVRGLHKSFGARHVLRGIDLAVRAGEVAAVLGPSGS
                     GKSTLLRGINHLERPDRGFVRIDGELIGYRRAGDRLRELREREVLRQRARIGFVFQDFH
                     LFPHLTVLGNLVEAPVSALRLPRAEAAALAGRLLDRVGLADRADAYPRQLSGGQQQRVA
                     IARALALRPKVLLFDEPTSALDPELVGEVLDVIRDLARAGTTMIVVTHEVAFAREVADT
                     VVFMDEGLIVERGSPRQVLDRPANPRTRAFLSKVL"
     gene            complement(2491..3501)
                     /locus_tag="LC193_RS27575"
                     /old_locus_tag="LC193_27575"
     CDS             complement(2491..3501)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1096: polar amino
                     acid ABC transporter, inner membrane"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006131956.1"
                     /locus_tag="LC193_RS27575"
                     /note="The N-terminal region of this protein, as described
                     by TIGR01726, is a three transmembrane segment that
                     identifies a subfamily of ABC transporter permease
                     subunits, which specificities that include histidine,
                     arginine, glutamine, glutamate, L-cystine (sic), the opines
                     (in Agrobacterium) octopine and nopaline, etc.; The
                     N-terminal region of this protein, as described by
                     TIGR01726, is a three transmembrane segment that identifies
                     a subfamily of ABC transporter permease subunits, which
                     specificities that include histidine, arginine, glutamine,
                     glutamate, L-cystine (sic), the opines (in Agrobacterium)
                     octopine and nopaline, etc; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="LC193_27575"
                     /product="amino acid ABC transporter permease"
                     /protein_id="WP_226078087.1"
                     /transl_table=11
                     /translation="MDIASAPGEALRHPPDPPATGTPGEADELAGLRIVPARHYGRWVA
                     GAAVLVLLGQFAHGLATNPGWDWDTFFAYLTAETVLKAVWLTVQLTLYGTVLGFALGVV
                     LACMRLSRSPVLRTVAWTYVWAFRSIPLIVQLLFWFNLAYLYREIGFGIPFGPVFWEFE
                     TLHLIGAMTAAVIGLALHQAAYAAEIVRGGVLSVDRGQTEAAAALGIPRLRQLRRIVLP
                     QAMRGILPNAANEIISLFKGTSIVSVMAIGELFYQVQVIYGRNGRVVPLLMVATVWYIV
                     LTTVLSVAQYYVERHFARGAERTAPPTPLQRLRARLRSARPLTAARAGAATGGRT"
     gene            complement(3530..4114)
                     /locus_tag="LC193_RS27580"
                     /old_locus_tag="LC193_27580"
     CDS             complement(3530..4114)
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018087921.1"
                     /locus_tag="LC193_RS27580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27580"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_226078088.1"
                     /transl_table=11
                     /translation="MTAPTPPTPPPAAPPAPGGVRVVRARVSDPVAAPLLRELGREYVS
                     RYGSAALREMTRYPDAEFAPPHGVLLLLVLDGAAVAGGAYRRYDEDTAELKRIWTHSAH
                     RRRGLARRVVAELERDAAARGYRRVRLTTGPRQPEAAGLYLAAGYTPLFDTAADPAGID
                     LLPFEKHLTPPTPRATAPATAGASPGGRGRR"
     gene            complement(4483..5655)
                     /locus_tag="LC193_RS27585"
                     /old_locus_tag="LC193_27585"
     CDS             complement(4483..5655)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018843007.1"
                     /locus_tag="LC193_RS27585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27585"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_226078089.1"
                     /transl_table=11
                     /translation="MPHGSGQGAGRPGLMAVAERAAVSPMTVTRVLRDDPRVLPGTRER
                     VLAAVAELAYLSDPEPPAAAGADPAARSGAADRGTGLVGVVVTDVTDPFASRLASGVDA
                     AVRRHGLRILIGDSRRDRERERGLVADLAGRADGIVVMPAGPRQEHLSAVAARGVPVVC
                     AGGPPAGFEADHVVIDDYGGAKEATERLLALGHRRIGFLGPRPDVWSGAERLRGHRTAL
                     RSAGLPLSDELVRREGAGAAERAAAELLALPEPPSALFCCGERYTVGAFRAVRAVGART
                     VLAGFDDFELADTLGLPLTVQICDSGELGRQAGRLLLDRMGGAPGRRQPPRRRVVSTRA
                     VRYGEGHSRGPLAPAPAGADGAAGDGAEGRHGAGTAGKGQRRNAAPGRTR"
     misc_feature    6013..6028
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.86"
                     /tool="antismash"
     gene            6052..6915
                     /locus_tag="LC193_RS27590"
                     /old_locus_tag="LC193_27590"
     CDS             6052..6915
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040183.4"
                     /locus_tag="LC193_RS27590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27590"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_226078090.1"
                     /transl_table=11
                     /translation="MPVSRSGRPTAAQLLIGARLRQLRTEAGLSTRQAAAELGTSASAL
                     HRMEGHGVGLEPGRVRRLLSAYGREGEAGAVLADVERASRPGWWDAYRDVLPRSPADLI
                     GLEEHAYVIRLYAPAVVPDLLQTPAYAEALQRVRHPEEDDRRIARRVELVVRRQALLER
                     ADPAPPVVWALLEEAALRRRVGDAEVMRGQLAHLRLLAARPGVTIRVVPMYTVHTALLC
                     GPVQLLRYRPATLPDRVLLHTLDGIEVEDRRDVVAQYLIALDSAASVPDSVPISAWRTD
                     WEDARA"
     gene            6902..7723
                     /locus_tag="LC193_RS27595"
                     /old_locus_tag="LC193_27595"
     CDS             6902..7723
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003989505.1"
                     /locus_tag="LC193_RS27595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27595"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_404819499.1"
                     /transl_table=11
                     /translation="MPVLEEQIDANRPDPARVYDWFLGGKSFFPADEAAGRQVQAMWPG
                     VRVAARANRAFLHRAVRWLAAEAGIRQFVDIGTGVPTEPNLHQIAQAEAPDTRVVYTDN
                     RLIVLRYAEALMTGTPEGRTAYLHADFCEPASILDSAELRDVLDLSRPVALCLNALLHY
                     IADDPVTGVTAHDLVARYVAALPSGSYLLITHVTPDFDAPTWERITSGDRGHTGQTGQI
                     RTREQILSFFEGMELVEPGLVPPQDWRPDGPVPAGATHAAVSMWAGIARRP"
     gene            8046..9503
                     /locus_tag="LC193_RS27600"
                     /old_locus_tag="LC193_27600"
     CDS             8046..9503
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031600.1"
                     /locus_tag="LC193_RS27600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27600"
                     /product="MFS transporter"
                     /protein_id="WP_226078092.1"
                     /transl_table=11
                     /translation="MSPTSSPPRSGTVVGVLAGAGIVTSLMQALVIPLIPELPALLGTS
                     AANASWVVTVTLLTGAVATPVVGRLGDLYGKRRMLLTCLALLVAGSLVCALADSLAPMI
                     LGRAFQGMSMGIIPLGISIMRDLMPPERLGSAIALMSSSLGIGGALGLPAAAAVAQNAD
                     WHMLFWGAAALGTVVAVLVLRAVPESRVRAGGPFDVTGALLLSCGLVALLLPISKGGDW
                     GWDAPVTLGLFGAAALVLALWCGWELRTPAPLVNLRSSVKRQVLVTNLASVLVGLAMFV
                     MMLVPVQILQLPEATGYGLGQSMLAAGLWMAPSGLVIVLVSPLGARLSAARGPRTSLLT
                     GALVIAFGYVIALGLSGSAWGVLAFTSVISVGIALAYAAMPALIMAAVPPSETAVANGL
                     NTLMRSIGTSTSSAVVGALLASMTIRFEGAELPSEQGLRTVLAFGACAALLATAVILAI
                     PRHAPADASAAPPAAARPPAGARHPAP"
     gene            9677..9973
                     /locus_tag="LC193_RS27605"
                     /old_locus_tag="LC193_27605"
     CDS             9677..9973
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LC193_RS27605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LC193_27605"
                     /product="hypothetical protein"
                     /protein_id="WP_226078093.1"
                     /transl_table=11
                     /translation="MRQNFNWDIITARSVVHITAGEVLPGTTEATPVTPGQNFHYHLGA
                     APVWVSNVSPHRNEFSGQAGGVEYLLHVDWSSPLDVAVTITVEDAVPVEIQGY"
     gene            complement(10001..10414)
                     /locus_tag="LC193_RS27610"
                     /old_locus_tag="LC193_27610"
     CDS             complement(10001..10414)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033537.1"
                     /locus_tag="LC193_RS27610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27610"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_226078094.1"
                     /sec_met_domain="PF13471 (E-value: 6.7e-26, bitscore: 89.0,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVPVALEHQPRLPVHRRLVPLLAVGAARLLSRLSPRRLRAVLLF
                     IRRGARAATADQALAARSAVVSVSLRCAGQGCLQRSIAAALVCRTRNVWPTWCTGVRTH
                     PFAAHAWIEVDGEPVGELYLGKHYRTLISIPPA"
     gene            complement(10411..10671)
                     /locus_tag="LC193_RS27615"
                     /old_locus_tag="LC193_27615"
     CDS             complement(10411..10671)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lasso_Fused_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604203.1"
                     /locus_tag="LC193_RS27615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27615"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_226078095.1"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 1.9e-06,
                     bitscore: 26.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 3.1e-24,
                     bitscore: 83.2, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.5e-13, bitscore: 49.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLRLRSDIATTSTEHGTVLLDERTGRYWQLNNTGSSVLHALLAG
                     QSQERIAAGLAERHDLDPRQARSDVTAIIDRLRAAKLLVTS"
     aSDomain        complement(10420..10668)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_LC193_RS27615_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="1.50E-26"
                     /identifier="RREFam002.1"
                     /label="LC193_RS27615"
                     /locus_tag="LC193_RS27615"
                     /protein_end="84"
                     /protein_start="1"
                     /score="83.2"
                     /tool="antismash"
                     /translation="SLRLRSDIATTSTEHGTVLLDERTGRYWQLNNTGSSVLHALLAGQ
                     SQERIAAGLAERHDLDPRQARSDVTAIIDRLRAAKLLV"
     aSDomain        complement(10501..10671)
                     /aSDomain="Lasso_Fused_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing fused peptidase in a lasso
                     peptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_LC193_RS27615_Lasso_Fused_RRE.1"
                     /evalue="9.50E-09"
                     /identifier="RREFam003.1"
                     /label="LC193_RS27615"
                     /locus_tag="LC193_RS27615"
                     /protein_end="57"
                     /protein_start="0"
                     /score="26.2"
                     /tool="antismash"
                     /translation="MSLRLRSDIATTSTEHGTVLLDERTGRYWQLNNTGSSVLHALLAG
                     QSQERIAAGLAE"
     gene            complement(10649..12511)
                     /locus_tag="LC193_RS27620"
                     /old_locus_tag="LC193_27620"
     CDS             complement(10649..12511)
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604202.1"
                     /locus_tag="LC193_RS27620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27620"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_226078096.1"
                     /sec_met_domain="Asn_synthase (E-value: 6e-35, bitscore:
                     119.9, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSDGFLVLPDAPFPRAFLDPVIRLGSVPYPSGRPWLLGRWAPGE
                     LIVAGTDSIQAAVIGTCPLTADRLTELISRVRRVEDLDMVTRALPGSFHLVASVAGVLR
                     VQGSLAGVRRVFHTSRDGVALAGDRSDVLATLIGAEIDEQTLAARVACGIRAPAPLAER
                     SMWQGVSPVPPDSYLRVDGRGTTATTVRWWEPPAPERSLAEGAELVREALRTAVSARSS
                     SAGRVSADLSGGMDSTSLCFLSAEAGVPDLLTFRWSEADEANADAGFAARAARELPAAE
                     HRELAQEAMPSVFADPGRITDTEAPYPFTRTAERTRQTARTLAECGSRTHLAGHGSDEL
                     FHELPYYLRDLLYRHPLTALTHLRGHRAMSRWPLTATIAALTDRRDLRAWWRQQADHLT
                     GPPRARRTPDLGWGYAPLRAQEWVTPSAIEVTRGLLHSIAEQARPLAAQRAQHATLMAL
                     RIAGPGYRQLARPFARAGVRLELPYLDDRVIEAALSVRFAERRTPWRYKPLLSEAMHGI
                     LPAAVAGRSTKGEAGEDVRIGLRRNMPALLELFADSALADHGLIDPDVLRTRLLAPQVD
                     NATTMALEELLGCETWLRAVKKTSTESWTPKADQGRVDESATTI"
     gene            complement(12637..12777)
                     /locus_tag="LC193_RS27625"
                     /old_locus_tag="LC193_27625"
     CDS             complement(12637..12777)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF033521.1"
                     /locus_tag="LC193_RS27625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27625"
                     /product="lasso RiPP family leader peptide-containing
                     protein"
                     /protein_id="WP_226078097.1"
                     /transl_table=11
                     /translation="MMSERVENSTMTPYEPPELVELGEFSEDTLGNNGIWWEPFNPQYD
                     Y"
     CDS_motif       complement(12688..12777)
                     /prepeptide="leader"
                     /note="peptide class: lassopeptide"
                     /note="predicted sequence: MMSERVENSTMTPYEPPELVELGEFSEDTL"
                     /locus_tag="LC193_RS27625_lassopeptide"
                     /aSTool="lassopeptides"
                     /tool="antismash"
     CDS_motif       complement(12637..12687)
                     /prepeptide="core"
                     /locus_tag="LC193_RS27625_lassopeptide"
                     /peptide="lassopeptide"
                     /predicted_class="Class II"
                     /score="7.40"
                     /molecular_weight="1982.1"
                     /monoisotopic_mass="1980.8"
                     /core_sequence="GNNGIWWEPFNPQYDY"
                     /aSTool="lassopeptides"
                     /tool="antismash"
                     /leader_sequence="MMSERVENSTMTPYEPPELVELGEFSEDTL"
                     /leader_location="[12687:12777](-)"
     misc_feature    complement(12957..12969)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.33"
                     /tool="antismash"
     misc_feature    complement(13033..13047)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.61"
                     /tool="antismash"
     gene            13153..13899
                     /locus_tag="LC193_RS27630"
                     /old_locus_tag="LC193_27630"
     CDS             13153..13899
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019890559.1"
                     /locus_tag="LC193_RS27630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27630"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_226078098.1"
                     /transl_table=11
                     /translation="MFTTRGPAFHELAVQALSSVERGYDLLAPKFDHTPFRTPDAVLAA
                     VRDALTPLGPFRRGLDLCCGTGAGLGVLTGLCQERVTGVDFSSGMLRVAGAAHRAVPGG
                     PALDLVRADARALPFLDAFDLVVSFGAAGHFLPAERPALFAGVRAALRPGGLLAFPVAA
                     PPRVGSAPYWALAGFDAAMRLRNALWRPPFVMYYRTFPLPRVRAELAAAGFSVGTVPLT
                     ALGTLPDGSPRCRLVLARRPGGKPAS"
     gene            complement(13907..14725)
                     /locus_tag="LC193_RS27635"
                     /old_locus_tag="LC193_27635"
     CDS             complement(13907..14725)
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018836143.1"
                     /locus_tag="LC193_RS27635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27635"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_226078099.1"
                     /transl_table=11
                     /translation="MANENGAATAGQAQDIDLSRPSIARVYDAVLGGKDNYEVDRVVAD
                     EVRRTMPHISDVGWYNRAVLGRAVRHLAVEAGIQQFLDLGAGLPTLENTHQVAQRHTPH
                     ARVAYVDNDPIVLAHGRALLEENEYTGVVTADLRDPEAVLAHPGVRRLIDFSQPVGVML
                     VGMLHHLHDDEDPQGIVDAYMGAVPPGSHLLLTHFCDTGPEARTVEETMLEFLGTGRFR
                     TMEEIEAYFRGLELLEPGVVSLPLWRPDSPVPLPLTVAQRLMAGGVARKP"
     misc_feature    complement(14793..14808)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 18.42"
                     /tool="antismash"
     gene            14934..15656
                     /locus_tag="LC193_RS27640"
                     /old_locus_tag="LC193_27640"
     CDS             14934..15656
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025054.5"
                     /locus_tag="LC193_RS27640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27640"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_226078100.1"
                     /transl_table=11
                     /translation="MREQKGTTGKVMVVRGFGTVRRAGGEDIEAAARALAAASVDEAVA
                     AWITPDEETRARRGAEAGQDIAAWLDTTRRSAEVLLVSGDDGIAGLAMWHFVDGAGDGD
                     GDEHADGPGDGGADAAGTDALIRVYGTDGLARMAQVREAVGRRHPSGVPHWHLSQTVIV
                     PELRGRGLGGALLRHHLDRVDEERAAAYLEASTPRSQALYERYGFLALGAPVELPDGGP
                     RLQPMWREGRSGLRPPGA"
     misc_feature    15863..15877
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     gene            16005..16595
                     /locus_tag="LC193_RS27645"
                     /old_locus_tag="LC193_27645"
     CDS             16005..16595
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006128686.1"
                     /locus_tag="LC193_RS27645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27645"
                     /product="TMEM165/GDT1 family protein"
                     /protein_id="WP_226078101.1"
                     /transl_table=11
                     /translation="MSLDLLAVLTAFGLIFLAELPDKTMFASLAMGTRMRPLYVWFGTS
                     TAFAVHVAIAVGAGSLIGLLPDWSVRLVSAVLFGLGAFLLLRGGGDDEEDGNAGGAGTV
                     TGFLPVWTTAFTAVFISEWGDLTQITTANLAATNGALPTAIGAAAALMSVSALALLVGR
                     FIARRVPLRTVQRIGGVCMLGLAVWSLIEVFAG"
     gene            16701..17462
                     /locus_tag="LC193_RS27650"
                     /old_locus_tag="LC193_27650"
     CDS             16701..17462
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018386656.1"
                     /locus_tag="LC193_RS27650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27650"
                     /product="ThuA domain-containing protein"
                     /protein_id="WP_226078102.1"
                     /transl_table=11
                     /translation="MTASTTQRPLSVTVWNENVHETTEPEVRARYPQGIHGEIAAAVRE
                     HVPDADVRTATLADPEHGLTEEVLAATDVLTWWGHRAHGEVADEVVARVRRHVLAGMGL
                     VVLHSGHLSKIFTTLLGTTCNLDWRSGEDRELVWTVDPTHPIAEGIPSPLIIPEQEMYG
                     EFFDIPAPDELVFISSFSGGEVFRSGCTFRRGHGRIFYFSPGDQAYPVYHHPGVRRVIA
                     NGVRWARGHAEQRRLPELHRREAGWFEGTGR"
     gene            17459..18586
                     /locus_tag="LC193_RS27655"
                     /old_locus_tag="LC193_27655"
     CDS             17459..18586
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018835094.1"
                     /locus_tag="LC193_RS27655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27655"
                     /product="Gfo/Idh/MocA family protein"
                     /protein_id="WP_226078103.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 1e-14, bitscore:
                     53.6, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 2.8e-10,
                     bitscore: 38.7, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAPPSFATVPGEGPLRVLVVGAGGMGRAWLRTVAADDRVALAGV
                     VDLDPATARRAVTEELGDVAVPVGASLSEVAARGGAQAVIDVTVPEAHLPVTLEAFGLG
                     LPVLGEKPLAADLAQATALVKAAADSGLLFMVSQSRRYDRGLWALRDRAASLGDLGVLT
                     QEFFRAPRFGGFREAMDHPLVLDMAVHNFDAARFVLGRDPVSVYCEEFNPSWSWYRGAA
                     GATAVFEMSGGVRFVYTGSWCAPGLETSWNSRWRLSGARGSATWDGEDEPVTQLADDAP
                     GAAVDHGPAPLPPGAGTAGALAEFVTALRTGRVPMGECHDNLLSLAMVHAAIASSAAGA
                     RVRVADVLASARAEAGIPAQSPYPAPEKTGSGFPG"
     gene            18802..19134
                     /locus_tag="LC193_RS27660"
                     /old_locus_tag="LC193_27660"
     CDS             18802..19134
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020124739.1"
                     /locus_tag="LC193_RS27660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27660"
                     /product="Lsr2 family protein"
                     /protein_id="WP_226078104.1"
                     /transl_table=11
                     /translation="MARKVVTIYTDDLTGEDTDEVSTHTFSIDGVNYEIDLAPDSFDQF
                     LSALGPFVNKARKTGRTQRSGSAPKRDRQTVDTARIRQWAKENGFDVNERGRVPASVRE
                     AYEQAH"
     gene            19329..20000
                     /locus_tag="LC193_RS27665"
                     /old_locus_tag="LC193_27665"
     CDS             19329..20000
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091938.1"
                     /locus_tag="LC193_RS27665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27665"
                     /product="AIM24 family protein"
                     /protein_id="WP_226078105.1"
                     /transl_table=11
                     /translation="MRSDLFSAEYQAQPPAAVGMSLQHSRSIKYVVDGECHARQGAMVA
                     FRGNLQFEVKSQGVGNFLKRAVTGEGLPLMVAKGQGEVWFAHNAQDCFIIDLEQGDGLT
                     INGRNVLCFDSSLGYRIKMVSGAGMAGGGLFNCEFEGQGRIGLISDGAPIVIPVSSQAP
                     VYVDTDAVVGWSSGLSSSINRSQSLKSMFRGGSGEAFQLVLQGEGFVIVQPSEAQPAVE
                     K"
     gene            complement(20127..20570)
                     /locus_tag="LC193_RS27670"
                     /old_locus_tag="LC193_27670"
     CDS             complement(20127..20570)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676632.1"
                     /locus_tag="LC193_RS27670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27670"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_226078106.1"
                     /transl_table=11
                     /translation="MSPQPEADATRAVVQDLLVRLGEGPPERIAELYAEQVDWRLDWPE
                     SAHGRAATPWIRHRTTRADVADHYRELAGHHVRGEADTQVERVLVDGEDAVVLGEIRQT
                     AESTKRAYRARFALHLTVTDGLITRQHTYEDSLAVAEAFDESA"
     misc_feature    complement(20649..20658)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 16.35"
                     /tool="antismash"
     gene            20791..21018
                     /locus_tag="LC193_RS27675"
                     /old_locus_tag="LC193_27675"
     CDS             20791..21018
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LC193_RS27675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LC193_27675"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_226078107.1"
                     /transl_table=11
                     /translation="MDSRRSVPCVVATGRHDAFFPPRVLAPAVRDRLGAGLRVVDGAGH
                     LVLDEKPATVAEMVNELHAAVNGPSRPPGQ"
     gene            complement(21111..22196)
                     /locus_tag="LC193_RS27680"
                     /old_locus_tag="LC193_27680"
     CDS             complement(21111..22196)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018560296.1"
                     /locus_tag="LC193_RS27680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_27680"
                     /product="Gfo/Idh/MocA family protein"
                     /protein_id="WP_226078108.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 2.6e-11, bitscore:
                     42.6, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEDPVRFGIVGSGWRAEFFLRLARALPDRLAVTGVVTRTAARGA
                     EVTAAWGVPAFRSAAELVAADRAPEFVVPSVPWSRTGPVTAELVALGVPVLAETPPAAD
                     LPGLREVWRAAGGSGLVQVAEQYPLMPGHVARRAVVEAGAVGEVTSVQLSSTHSYHAVS
                     LIRHLLGTGFEPATVTARSFTAPLADPLTKDGWSDDLAPRQAATTLALLDFGGRTALYD
                     FTDNQWWNPLRARRMVVRGSLGEIVDDTVVRMADPRTPMTSSLTRRTTGTDLNLEGREL
                     HHISFDGRVVYRNAYVGASFSEDDLAVVDLLCRTGAWARGQGPEPYPLAEGCQDHLIGL
                     AISESARTGTPVTTTREPWAS"
     misc_feature    22338..22358
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 21.07"
                     /tool="antismash"
     misc_feature    22342..22360
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: medium, score: 30.19"
                     /tool="antismash"
     misc_feature    complement(22347..22365)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 23.56"
                     /tool="antismash"
ORIGIN
        1 cacgccgttc gcggctctcg cgctgctcgt cgtgctcttc atcaaggaga agccgctgaa
       61 gaccaccagc ggctcggagc ggctcgccga ggaggccgcg gccggggagg tcgcggaacg
      121 tgcggacggc accggcccgg acgcccaggc tcccggctcg gcgcagaccc tgtccaaggg
      181 cgccgcgccc ggggacgcgg ggggcgccca ggacgagacg cccgtcaccc cggcacgctg
      241 acgccggccc ggccggccgc cgcgcccgcc gcccggcctc ccaggcccgg gcggcgggcg
      301 cggtcgcgcg tggtcgcggc gcgcggcgcg ggccgcgctc cggtgccgcc cccctggcgc
      361 ccccacgggg ccgcagggta gcgtccgact cggccgcggc ccgcgttccg cccgccgagg
      421 ccgtcgggtg ccgccgctcc ctccggctgc ccgtcccccc gtcccgcccg tgtgcgcctc
      481 cgaggccgcg gcgccgccgg ccatgtgccg ggtgcccgcg cgggtgccgg gccggcgtcc
      541 cggccggccc ggcacccttg gggcaggcgc gtcccgcctc ggcaggcgag cccgcgctca
      601 ctcctcggcg cgcggcagcc ccggcgggtt gacctccgac acctcgacgg cctcgtccgc
      661 caggccccac cggtcgagca cctgcccgta ggtgccgttg tcgatgacgg tgttcagcgc
      721 ttcgttcagg gcccgcacga gcccgttgtc cttcttcgtc gtcgcggcga tctcgccctg
      781 gatctccgcc cccgcgccgg agaagctgcc gatgatctcg gtctcaccgg tgaccgccgc
      841 gtggtacgcg gccaccggat tgggaccgaa gtaggcgtcg atgcgcccgg aggacagggc
      901 caggtagtag tccgtcgcgt tctggaagta cttgatgtcg gtggcgtcga ggccgtccgc
      961 cacgttctgc tcgctccacg acaccagcag ctcctcctgg ttcgtgccgg agctgacccc
     1021 gatcgtgcgg cccgccacgt cccgggcgcc ctcgacgcgc cagtcgccgc ccgccctggc
     1081 ctcgaaggcg acgttgtcca gccggtacgt cgcgaaatcg tacttgtcct tgcgctcctc
     1141 ggtgaccgtg atgttgctga atccgacgtc gtagcgcccg ctgtccagcc cgacgaacaa
     1201 gttggcccag tcgacggtgt ggtagcggac ctcaagtccc agcacgtcac cgaccagcga
     1261 cgcgatgtcc gtctccacgc cgatgacggt ctcgtcgtcc gtggcgtaga acgtcagcgg
     1321 cggcgcggag ccgggggagt gggccacttc cagcgtgccg cggtcacgga tctcctcggg
     1381 cagcagcgcg gcgacggcgt ccacgcgttc ggtgccgatc cggtcctggt cgggcccgag
     1441 gtggacgccc gtcccctcgc ccgcggcgcc cgcgggggcc gggccgccgc ccccgtccgc
     1501 cccgggaccg gcgcacgcgg tgagggcgag cgcgacggcc agccaggacg cgagggcggg
     1561 caagcggcgg cgggcggcgg gacgggggcg atggcggcgc acgcgaggtc ctttccttcc
     1621 ggccgggtga ccggcacggg tgaacgggag gatgggcgaa cgggggagcg ggaacgacgg
     1681 gtgaccgccg tgggcggagc gcgcgggggc ggcggcccgc tcagagcacc ttggacagga
     1741 acgcccgggt gcgcgggttg gcgggccggt cgagcacctg ccgcggggag ccgcgttcga
     1801 cgatcaggcc ctcgtccatg aacacgacgg tgtcggcgac ctcgcgcgcg aaggcgacct
     1861 cgtgggtgac gacgatcatc gtcgtgccgg cgcgggccag gtccctgatg acgtcgagca
     1921 cttcaccgac cagttcgggg tcgagcgccg acgtgggctc gtcgaacagc agcaccttgg
     1981 gccgcagcgc cagcgccctg gcgatcgcga cccgctgctg ctggccgccg gacagctgcc
     2041 tcgggtaggc gtccgcccgg tccgccaggc ccacccggtc gagcagccgg ccggcgagcg
     2101 cggcggcttc ggcgcgcggg agccgcagcg cggagacggg agcctcgacg agattgccga
     2161 gaacggtcag gtgcgggaag aggtggaaat cctggaacac gaagccgatc cgcgcccgct
     2221 gccgcagcac ctcgcgctcc cgcagctccc gcagccggtc gccggcgcgc cggtacccga
     2281 tcagctcgcc gtcgatccgc acgaagccgc ggtcgggccg ctccaggtgg ttgatgccgc
     2341 gcagcagggt cgacttccca gaaccggacg gcccgagcac cgcggccacc tccccggcgc
     2401 gcacggcgag gtcgatgccc cgcagcacgt gccgcgcgcc gaacgacttg tgcagccccc
     2461 ggacgtcgac catcgtccgc cgcccgccgc tcatgtccgc cccccggtgg ccgccccggc
     2521 ccgcgcggcc gtcagcggcc gggcggaccg caaccgggcc cgcagccgtt gcagaggggt
     2581 gggcggcgcg gtgcgctcgg cgccgcgcgc gaagtgccgt tcgacgtagt actgggcgac
     2641 ggacagcacc gtggtgagca cgatgtacca gacggtcgcg accatcagca gcggcacgac
     2701 gcggccgttg cgcccgtaga tcacctgcac ctggtagaac agctcgccga tcgccatgac
     2761 cgagacgatc gacgtgccct tgaacaggga gatgatctcg ttcgccgcgt tcggcaggat
     2821 gccgcgcatg gcctgcggca gcacgatccg gcgcagttgg cgcagccgcg gtatgccgag
     2881 ggccgcggcg gcctccgtct gcccccggtc caccgacagc acgccgccgc gcacgatctc
     2941 ggcggcgtag gcggcctggt gcagcgcgag cccgatgacc gccgcggtca tggcgccgat
     3001 caggtgcagc gtctcgaact cccagaacac agggccgaag gggatgccga agccgatctc
     3061 ccggtacagg taggccaggt tgaaccagaa cagcagctgc acgatcagcg ggatcgaccg
     3121 gaacgcccac acgtaggtcc aggccaccgt gcgcagcacc gggctgcggg agagccgcat
     3181 gcaggcgagg accacgccga gggcgaagcc gaggaccgtg ccgtacagcg tgagctggac
     3241 cgtcagccac acggccttga ggaccgtctc cgccgtcagg taggcgaaga acgtgtccca
     3301 gtcccagccc gggttggtgg ccaggccgtg cgcgaactgg ccgagcagca ccaggacggc
     3361 ggcgccggcc acccaccgcc cgtagtgccg ggccggcacg atccgcagcc cggccagttc
     3421 gtcggcctcg cccggcgttc cggtcgccgg cggatcgggt gggtggcgca gggcctcgcc
     3481 cggcgctgac gcgatgtcca tggtctcggg cctttcggtc gcgtcctggt caccggcgcc
     3541 cgcgaccgcc ggggctcgcc ccggcggtcg cgggcgcggt ggcgcggggc gtgggcgggg
     3601 tgaggtgctt ctcgaagggc agcaggtcga tgcccgccgg gtcggccgcg gtgtcgaaca
     3661 gcggtgtgta gccggccgcc aggtacagcc ccgcggcctc cggctgccgc ggcccggtgg
     3721 tcagccgcac gcgccggtag ccgcgtgcgg cggcgtcccg ctccagctcg gccaccacgc
     3781 gccgggcgag tccgcggcgg cggtgcgcgg agtgggtcca gatccgcttc agctcggcgg
     3841 tgtcctcgtc gtacctgcgg taggcgccgc cggcgacggc cgcgccgtcc aggacgagga
     3901 gcagcaggac gccgtgcggc ggcgcgaact cggcgtcggg atagcgggtc atctcgcgca
     3961 gcgcggcgct gccgtagcgg gagacgtact ccctgccgag ttcgcgcagc agcggggccg
     4021 cgacggggtc ggagacgcgg gcccgcacga cccgcacgcc accgggggcg gggggtgcgg
     4081 cgggcggggg agtgggaggt gtcggcgcgg tcatacctgg tcgtacccgg cctttcctgc
     4141 gggggaggtg gaaggtgtcg gggcagggga acgcggcgtc cggcgcgcgt cgcgggacgg
     4201 ccggggcgcg ggtgggcgtg cgcgggcgtg cgaagggcgt ggacggcgcg ttccgcgcgg
     4261 ggaagcgggg agcgggcggc gccggcatac gccgggcgtg cgcacgcgcg caccggaagg
     4321 ggcgcggcgg ctcggaaagc gcggggaggc gcgggccgcg gtgctaccgg gtcagacgcg
     4381 acacgaggcc gaccacaccc gaccgaagtc gatgtggccg cgcgtgacca aaggcaactc
     4441 gacgctcacg tcgaacagtt gagcatcacg tgtgcgcccg cgtcaacggg tgcgaccggg
     4501 cgcggcgttg cgccgctgcc ccttccccgc ggttcccgcc ccgtgccgcc cttccgcccc
     4561 gtccccggcg gcgccgtccg cgcccgcggg tgccggagcc agcgggccgc ggctgtgtcc
     4621 ttcgccgtac cgcacggccc tggtggacac caccctccgg cgcggcggct gccgccggcc
     4681 cggcgccccg cccatccggt cgagcagcaa ccggcccgcc tggcggccga gttcgccgct
     4741 gtcgcagatc tggacggtca gcggcagccc gagcgtgtcc gccagctcga agtcgtcgaa
     4801 cccggccagc accgtgcggg cgcccaccgc ccgcaccgcg cggaacgccc cgacggtgta
     4861 ccgctcgccg cagcagaaca gggcgctcgg cggctcgggg agggccagca gctccgccgc
     4921 ggcccgttcc gccgccccgg ccccctcccg ccgcaccagc tcatcggaga gcggcagccc
     4981 cgcggaacgg agcgcggtcc tgtggccgcg caggcgttcc gcgccgctcc acacatccgg
     5041 ccggggaccc aggaagccga tccgccggtg cccgagcgcc agcagccgct cggtggcctc
     5101 cttggccccg ccgtagtcgt cgatcaccac gtggtccgcc tcgaaacccg cgggcgggcc
     5161 gcccgcgcac accacgggaa cgccccgcgc ggcgacggcg gacaggtgct cctggcgcgg
     5221 ccccgcgggc atcacgacga tgccgtccgc gcggcccgcg aggtcggcca cgagcccgcg
     5281 ttcgcgctcc cggtcccgtc ggctgtcacc gatgaggatg cgcagcccgt gccggcgcac
     5341 ggccgcgtcc acgccggagg cgaggcgcga ggcgaacgga tcggtcacgt cggtgacgac
     5401 cacgcccacg agacccgtgc cgcggtccgc cgccccggag cgggcggcag ggtccgcccc
     5461 ggccgcggcg ggcggctcgg ggtcggacag gtaggccagt tccgcgaccg cggcgagtac
     5521 ccgttccctg gtgccaggca ggacccgcgg gtcgtcgcgc aggacccggg tgacggtcat
     5581 cgggctcacc gcggcgcgtt ccgcgaccgc catgaggccc ggccggccgg ccccctgtcc
     5641 tgacccgtgc ggcatcgtgc ccggcggtcc cttctgtggt cgcggcgccg gcccggcggc
     5701 gcgccgcgat ccggcctcca ccggagcgga gccgaccgcc gtccgccgat cggacggcct
     5761 gtgatgacgg accctaggcc gacggacggg gacctgccaa ggccgcgcgc gatcacgttc
     5821 gcgcccgcgg ccggcccggg gcgaacgggc gaacggcggg tgtcctcgcg gtgcccggtc
     5881 ggtgacgtcg gggcgaacgg cccggctccc gcggcggtcc cgcccggttc gcggtgtacg
     5941 cgccgtggcc cgcgcgggac ggacagccac cgttgtggtg gctctgccat tctgcaactg
     6001 gcagaatggc gcggcacatt gtcgtcactc ctccggggaa gggggcgcgg tatgccggtg
     6061 tcgcgctccg gccgtcccac ggccgcccag ctgctgatcg gtgcccgcct gcggcaactt
     6121 cgcaccgagg ccggtctctc cacccgccag gccgcggccg aactcggcac gtcggcctcg
     6181 gcccttcacc ggatggaggg ccacggcgtg gggctcgaac cgggacgcgt acgaagactc
     6241 ctgagcgcct acggccggga gggcgaggcc ggcgcggtgc tcgccgacgt cgagcgggcg
     6301 agccggcccg gctggtggga cgcctaccgc gacgtgctgc cgcgttcgcc cgccgacctg
     6361 atcggccttg aggagcacgc gtacgtgatc cggctctacg cccccgcggt cgtgcccgac
     6421 ctgctccaga ccccggccta cgccgaggcg ttgcagcggg tgcggcaccc ggaggaggac
     6481 gaccggcgca tcgcccggcg ggtggaactc gtcgtgcggc ggcaggcgtt gctcgaacgc
     6541 gccgacccgg cgccccccgt ggtgtgggcg ctgctcgaag aggcggcgct gcgccgccgg
     6601 gtgggcgacg cggaggtgat gcgcggtcaa ctggcgcacc tgcggctgct ggccgcgcgc
     6661 cccggcgtca cgatccgcgt cgtcccgatg tacaccgtgc acaccgccct gctctgcggc
     6721 ccggtccagt tgctccgcta ccggccggcc acgctgcccg accgggtgct gctgcacacc
     6781 ctggacggca tcgaggtcga ggacaggcgc gacgtggtgg cgcagtacct gatcgcgctg
     6841 gactccgcgg cctccgtgcc ggacagcgtg ccgatctccg catggcggac cgactgggag
     6901 gatgcccgtg cttgaggaac agatagacgc caaccgcccc gacccggccc gggtgtacga
     6961 ctggttcctc ggggggaaga gcttcttccc cgccgacgag gccgcggggc gccaggtgca
     7021 ggcgatgtgg cccggcgtgc gggtcgcggc ccgcgccaac cgcgcgttcc tccaccgggc
     7081 ggtgcggtgg ctggcggccg aggccggcat ccggcagttc gtcgacatcg gcaccggcgt
     7141 gcccaccgag ccgaacctgc accagatcgc ccaggccgag gcgcccgaca cacgcgtggt
     7201 ctacaccgac aaccggctga tcgtcctgcg gtacgccgag gcgctgatga cgggcacgcc
     7261 cgagggccgc acggcctacc tgcacgccga cttctgcgaa cccgcgtcca ttctggacag
     7321 cgccgaactg cgggacgtgc tcgacctgtc ccggcccgtc gccctgtgcc tgaacgccct
     7381 gctgcactac atcgcggacg atccggtcac gggggtgacg gcgcacgacc tggtcgcgcg
     7441 atacgtcgcc gcgctcccct cgggcagtta cctgctgatc acgcacgtca ccccggactt
     7501 cgacgccccg acctgggagc ggatcacctc gggcgaccgg gggcacaccg ggcagacggg
     7561 gcagatccgc acccgcgagc agatcctgtc cttcttcgag ggcatggagc tggtcgagcc
     7621 ggggctcgtc ccgccccagg actggcgtcc cgacggcccg gtgcccgcgg gggccaccca
     7681 cgccgccgtg tccatgtggg cggggatcgc gcgccggccg tgaccccggg ccgcccgcgc
     7741 gccgggtcct ggacctggcg cgcggtgcgc cgatgcggcg cgggtggcgg cctcaacggc
     7801 ggggtgggcg gcggaggaac gcggcgtcgg cgtgacggac gggaaacgtc acgttgtgtc
     7861 cgtcgtcatc cggcgaaagg ccggatcagc tcgtgcttcg acacatcctg tacggaacac
     7921 gttcaactgg tcatccgatt gaatgtataa cgcatctttt gtgtaccgta cggaggttgc
     7981 gcacgccacg gtccgccgcc gcggcgcacg agccctcccg cccccacccc cgagcggaga
     8041 cccgcatgag tccgacctcg tccccgccgc gcagcggcac cgtcgtgggc gtgctggccg
     8101 gcgccggaat cgtgacgtcc ctgatgcagg ccctcgtcat ccccctgata cccgaactgc
     8161 ccgcgctgct cggcacctcg gcggcgaacg cctcctgggt ggtgaccgtg accctgctca
     8221 cgggagccgt cgccacaccg gtggtcgggc ggctcggcga cctgtacggc aagcggcgca
     8281 tgctcctgac ctgtctcgcc ctgctggtcg cgggctccct ggtctgcgcg ctcgccgact
     8341 cgttggcccc catgatcctc ggccgcgcgt tccagggcat gagcatgggc atcatccccc
     8401 tcggcatcag catcatgcgc gacctcatgc cgccggaacg actcgggtcc gcgatcgccc
     8461 tgatgagttc ctcgctcggc atcggcggcg cgctcggcct gccggccgcc gccgcggtcg
     8521 cccagaacgc cgactggcac atgctgttct ggggcgcggc ggcgctgggc accgtcgtgg
     8581 ccgtgctggt gctgcgcgcg gtgcccgagt cgcgggtccg ggccggcggc ccgttcgacg
     8641 tgaccggcgc cctgctgctc tcctgcggcc tcgtcgccct gctgctgccc atctccaagg
     8701 gcggcgactg gggctgggac gcgcccgtca ccctcggcct gttcggcgcg gcggccctcg
     8761 tgctggcgct gtggtgcggg tgggaactgc gcacccccgc gcccctggtc aacctcaggt
     8821 cgagcgtcaa acggcaggtg ctggtcacca acctggcgtc cgtgctggtc ggcctcgcca
     8881 tgttcgtcat gatgctcgtc cccgtgcaga tcctccaact gcccgaggcc accgggtacg
     8941 gcctcggcca gtccatgctg gcggccggcc tgtggatggc gccgtccggc ctggtcatcg
     9001 tgctcgtctc gccgctgggc gcccggctgt ccgccgcccg cggccccagg acctccctgc
     9061 tcaccggcgc cctcgtcatc gcgttcggct acgtcatcgc gctcggcctc tccggatccg
     9121 cgtggggcgt gctggccttc acctcggtga tcagcgtggg catcgccctc gcctacgcgg
     9181 cgatgcccgc cctcatcatg gccgccgtgc cgccctcgga gacggcggtc gccaacggcc
     9241 tcaacaccct gatgcgctcc atcggcacct ccacgtcgag cgcggtggtc ggtgcgctgc
     9301 tcgccagcat gaccatccgc ttcgagggcg cggagctgcc ctcggagcag ggcctgcgca
     9361 ccgtgcttgc cttcggcgcg tgcgccgcgc tgctcgcgac ggccgtgatc ctggccattc
     9421 cgcggcacgc gcccgcggac gcctccgcgg cgccgcccgc cgcggcccgc ccgccggccg
     9481 gcgcccgcca cccggctcct tgaccccgcg cgccaccgca cggcgcagct gccacgccgc
     9541 cgcggaatgg agaaagcccg ggatgcggag cccgtattcc ggaggtaaat tcaacggagg
     9601 gggtgttccg gaatccgcag ggagcatgac gatgggtcaa tccatacgct acgtgaggcg
     9661 gggcgtccaa ggggttgtgc gtcagaactt caattgggac atcatcacgg ctcgctccgt
     9721 ggtgcacatc accgcaggtg aagttctgcc cggcacgacc gaggcgactc ccgtcacgcc
     9781 gggccagaac ttccactacc acctgggtgc ggcgcccgta tgggtctcca acgtctcgcc
     9841 tcaccgcaat gagttcagcg gccaggccgg tggagtggaa tacctcctcc acgtcgactg
     9901 gtcgtcgccc ctggacgtcg ccgtcacgat cacggtcgag gacgctgtcc cggtggagat
     9961 ccagggttac tgagaccgct gagccttttt tcggcctctt tcaggcgggg ggaatggaaa
    10021 tgagcgtccg gtaatgttta ccgaggtata gctctccgac gggttcgccg tcgacttcga
    10081 tccacgcatg tgccgcgaat ggatgcgtac ggacaccggt acaccaggtg ggccagacat
    10141 tgcgggttcg gcagaccagg gccgcggcga tggaccgttg cagacagccc tgacctgcgc
    10201 agcgaagact gaccgagacg accgcgctac gtgccgcgag tgcctggtcg gcggtggcgg
    10261 ctcgggcacc gcggcggatg aagagcagaa cggctcgtag cctgcgcggt gacagtcggc
    10321 tgagcaggcg cgccgcaccg accgcgagca gcggcaccaa ccgcctgtgg accggaagcc
    10381 ggggctggtg ttcgagtgcg acgggaacgg tcacgaggtc accagcagct tcgccgcgcg
    10441 aagacgatcg atgatcgccg tcacgtcgga ccgtgcctgc ctgggatcga ggtcgtgccg
    10501 ctcggcgagg cccgccgcga tccgctcctg gctctgaccg gccagcagcg cgtgcagaac
    10561 gctgctgccg gtgttgttga gctgccagta gcgtccggtg cgctcatcga gcagaacggt
    10621 gccgtgttcg gtgctggtgg tggcgatgtc agatcgtagt cgcagactca tcgaccctcc
    10681 cttggtcggc tttcggggtc cagctttccg tcgaggtctt cttgacggcg cgcagccagg
    10741 tctcacaccc gagcagttct tccaacgcca tggtggtggc gttgtcgacc tgcggggcca
    10801 gcagccgggt acgcagcacg tcaggatcga tcagcccgtg gtcggccagc gccgaatcgg
    10861 cgaacagttc gagtagggca ggcatgttgc gccgcaaccc gatgcgcacg tcctcgcctg
    10921 cctcaccctt ggtggatcgg cccgcgacgg cggcgggcag gatgccgtgc atcgcctcgg
    10981 acagcagcgg tttgtagcgc cacggcgttc gacgctcggc gaatcgaacg gacagcgcgg
    11041 cctcgatcac ccgatcgtcg aggtacggca gctccaaccg cacaccggcc cgcgcgaacg
    11101 gcctggcgag ctggcggtag ccgggtcccg cgatgcgcag cgccatcagc gtcgcgtgct
    11161 gcgctcgttg cgcggccaac ggtcgcgcct gctcggcgat gctgtgcaac agcccgcgcg
    11221 tcacctcgat cgcggacggc gtgacccatt cctgtgctcg cagcggcgcg taaccccatc
    11281 cgagatcggg cgtacggcgg gcgcgaggcg gaccggtgag atggtcggcc tgctgccgcc
    11341 accacgcgcg gaggtcgcga cgatcagtga gcgcggcgat ggtggcggtc aacggccaac
    11401 gggacatcgc ccggtgacca cgcaggtgag tgagtgcggt cagcggatgg cggtacagca
    11461 ggtcccgcag gtagtagggc agctcatgga acaactcgtc ggagccgtgc ccggccaggt
    11521 gtgtccgcga cccgcactcg gccagggtcc gggcggtttg cctggtccgc tcggcggtac
    11581 gtgtgaaggg atacggcgcc tcggtatcgg tgatgcgtcc gggatcggcg aagaccgatg
    11641 gcatggcttc ttgcgccagt tcccgatgtt cggcagcggg caattccctg gccgcccgcg
    11701 ccgcgaaccc cgcatcggcg ttcgcctcgt cggcctcgct ccagcggaag gtcagcaggt
    11761 cgggaacccc ggcttcggct gacaggaagc acaacgaggt ggagtccatc ccaccggaca
    11821 gatccgcact gacccggccc gccgaggaag agcgcgcgga caccgctgtc cgcagcgcct
    11881 cacggaccag ttccgcacct tctgccagcg acctctccgg cgcgggtggc tcccaccagc
    11941 gcaccgtggt cgccgttgtc cctcggccgt cgacccgcag gtaggagtcc ggcggcaccg
    12001 gactcacgcc ctgccacatc gagcgttcgg ccaacggcgc gggcgcccgg atcccgcacg
    12061 ccacgcgggc cgccagggtc tgctcgtcga tctccgctcc gatcagcgtg gccaggacat
    12121 cggatcggtc acctgcgagc gccacgccgt cccggctggt gtggaacacg cggcgaacgc
    12181 ccgccaggct gccctgcacc cgcagcacgc ccgcgaccga cgccaccaag tggaaactgc
    12241 ccggcaacgc gcgggtcacc atgtccaggt cttcgacccg gcgcacccgg gagatcagtt
    12301 cagtcaatcg atcggcggtg agcggacagg tgccgatcac cgctgcctgt atcgagtccg
    12361 tcccggcgac gatcagttca ccgggagccc atcgtcccag cagccatggc cgaccggagg
    12421 ggtagggcac tgacccgagc cgaatcaccg gatcgaggaa cgcgcgaggg aacggggcat
    12481 ccggcagcac caggaaaccg tcggacagca ccgtcgatca acccctaact tccctactga
    12541 ccgtggagga gactcgttat ttatggtggg gattcacatt cgggtcggcg gaatgggtgg
    12601 tgatcggacg tggcccgatc accaccgggt cgagtgtcag tagtcgtact gggggttgaa
    12661 gggctcccac cagatgccgt tgttgccgag ggtgtcttcg ctgaactcgc ccagctccac
    12721 gagttcgggc ggctcgtacg gcgtcatcgt cgaattctcg acccgttcgc tcatcatgtt
    12781 tcctctctcg tcctacgcgt caggacaacg gaagtgtcac gctcaccggc gggcaggaag
    12841 acgcgacagc ccaggccacg cgaccactcg cggaatggta aggctgaccg ttcgggaggg
    12901 gtccccggaa ccctcccgca taatgagcta ttttcgtgcg cccaggagga caggaggtga
    12961 caccgtgacg cagcggtgtt cttgctgtcc ggaaagctcg ccgtcgcctg ctggtggcag
    13021 tccggtccgg gcagctgcct gaaaaaaggg cggcgcaggt tggcaaccac cgggccccga
    13081 agcgaccggc cgatcccccc tcgccccggg agcagtgctc gggcgcccag gccgattcgc
    13141 taccgtgggc ccgtgttcac cacccggggc cccgcgttcc acgaactggc cgtgcaggcg
    13201 ctgtcgtcgg tcgaacgcgg ctacgacctg ctggcgccga agttcgacca cacaccgttc
    13261 cggaccccgg acgcggtgct cgccgccgtc cgcgacgccc tgactccgct cgggccgttc
    13321 cgccgcggcc tcgacctgtg ctgcggcacc ggcgccggcc tcggcgtgct caccggactg
    13381 tgccaggagc gcgtcaccgg cgtcgacttc agctccggca tgctccgggt ggccggggcc
    13441 gcccaccggg ccgtgcccgg cgggcccgcc ctcgacctgg tcagggccga tgccagggcg
    13501 ctgccgttcc tcgacgcgtt cgacctggtc gtcagcttcg gcgcggccgg ccacttcctg
    13561 ccggcggaac ggcccgccct gttcgcgggc gtgcgcgccg cgctcaggcc cggcggcctg
    13621 ctggccttcc ccgtggccgc gccgccgcgc gtcgggtccg cgccctactg ggcgctcgcc
    13681 gggttcgacg cggcgatgcg gctgcgcaac gcgctgtggc gcccgccgtt cgtcatgtac
    13741 taccgcacgt tcccgctgcc ccgggtgcgc gcagaactgg ccgccgccgg cttctccgtg
    13801 ggcaccgtgc cgctcaccgc gctcggcacc ctgcccgacg ggagcccgcg ctgccgcctg
    13861 gtgctggcgc ggcgcccggg cgggaagccc gcgtcctgac ggggcgtcag ggcttgcgtg
    13921 ccacgccccc ggccatcagc cgctgggcca cggtcagcgg cagcgggacc ggggagtccg
    13981 gccgccacag cggcagcgac accacgccgg gttcgagcag ttcgaggccg cggaagtacg
    14041 cctcgatctc ctccatcgtg cggaaccgcc cggtgccgag gaactccagc atcgtctcct
    14101 cgaccgtgcg ggcctcgggt cccgtgtcgc agaagtgcgt cagcagcagg tggctccccg
    14161 ggggtacggc ccccatgtag gcgtcgacga tgccctgcgg gtcctcgtcg tcgtgcaggt
    14221 ggtgcagcat gccgacgagc atcacgccga ccggctggga gaagtcgatc agacgccgca
    14281 cgccggggtg cgcgaggacg gcctccggat cgcgcagatc ggccgtgacc acgcccgtgt
    14341 actcgttctc ctccagcagg gcccggccgt gggccagcac gatcgggtcg ttgtcgacgt
    14401 aggccacccg tgcgtgcggc gtgtgccgct gggccacctg gtgggtgttc tccaacgtcg
    14461 gcaggccggc cccgagatcg aggaactgct ggatcccggc ctcgacggcc aggtggcgca
    14521 ccgcgcggcc gagcaccgcg cggttgtacc acccgacgtc gctgatgtgc ggcatcgtgc
    14581 ggcgcacttc gtcggcgacc acgcggtcga cctcgtaatt gtccttgccg cccaggaccg
    14641 cgtcgtacac ccgcgcgata ctcggcctgc tgaggtcgat gtcctgggcc tgaccggccg
    14701 tggccgcgcc gttctcgttc gccattgaag aggtcccaac ttccgtctcg cggcccgtcg
    14761 ttggcgggcc cgcccgtgcc gtggcgcaca gggtaacctc cgggtgaccg gttcgcgcac
    14821 ccgttcccct ctcaacctcg ctcaccgccg cggaagttga cgcggggccc ggccgccgtc
    14881 ggagcacagc cggttcccgg caaccttccg ggccgtgccc ggggtcttgt tgggtgagag
    14941 agcaaaaggg aacgacgggc aaggtgatgg tggtgcgcgg tttcggcacg gtccggcggg
    15001 ccgggggaga ggacatcgag gcggcggcgc gggcgctcgc ggcggcctcc gtggacgagg
    15061 ccgtggcggc gtggatcacg ccggacgagg agacgcgcgc acggcggggc gccgaggcgg
    15121 ggcaggacat cgccgcctgg ctcgacacga cccgccggag cgccgaggtc ctgctcgtga
    15181 gcggtgacga cggcatcgcg gggctcgcca tgtggcactt cgtcgacggt gccggcgacg
    15241 gcgacggcga cgagcacgcg gacgggccgg gcgacggcgg cgcggacgcg gccggcaccg
    15301 acgcgctgat acgcgtctac ggaacggacg gcctggcccg catggcccag gtgcgggagg
    15361 cggtgggccg ccggcacccg agcggcgtcc cgcactggca cctgtcgcag accgtgatcg
    15421 tgcccgagct gcgtgggcgc ggcctcggcg gtgcgctgct gcgccaccac ctggaccgcg
    15481 tggacgagga gcgggcggcg gcctacctgg aggccagcac tccgcgcagc caggcgctgt
    15541 acgagcggta cggcttcctc gcgctcgggg cgccggtcga gctgccggac ggcgggccgc
    15601 gactccagcc catgtggcgg gaggggcgtt ccggactcag gcccccgggg gcgtgagccg
    15661 gcgggccacc gggccccggc cgcgcgcgcc cgggaccggc gcgtacgccc ccgggggccg
    15721 cccgggccgc gccggtcccg cgcccggtag catgggcggc agcgaagggg agtagtcccg
    15781 caacaccggc cggtcgacat actggccatc cgcacgcgga tggcccggcc gccgggccgc
    15841 ggcccgccag ggccccggtg gacgagacct tcggccaggc acgactctgc ccgcaccttc
    15901 cggtgcgggc cggacgacat gccgggccga gtggtcctcc ccgctcccgc tgggacattc
    15961 cgtgaggtgc cacgcgaccc ggcccgcaca gaaagctcac cggcatgtcc ctcgacctcc
    16021 tggcggtgct caccgccttc ggcctcatct tcctcgcgga gctgcccgac aagacgatgt
    16081 tcgcgtcgct ggccatgggc acccgcatgc gaccgctgta cgtctggttc ggcacctcga
    16141 ccgcgttcgc ggtgcacgtg gcgatcgcgg tcggcgcggg cagcctcatc ggcctgctgc
    16201 ccgactggtc ggtgcggctg gtgtccgcgg tcctcttcgg cctcggcgcg ttcctcctgc
    16261 tgcgcggcgg gggcgacgac gaggaggacg ggaacgcggg gggcgccggg acggtgaccg
    16321 gcttcctgcc ggtctggacg accgcgttca ccgccgtgtt catcagcgag tggggcgacc
    16381 tgacccagat caccaccgcg aacctcgccg ccaccaacgg cgccctgccc accgccatcg
    16441 gcgccgccgc ggccctgatg agcgtgtccg cgctcgccct gctggtcggc cggttcatcg
    16501 cccggcgcgt gcccctgcgg accgtgcagc gcatcggcgg ggtgtgcatg ctcggcctcg
    16561 ccgtctggtc cctgatcgag gtcttcgccg gctgaggcgg ccgtcgcggc ccggcccccc
    16621 gcgggcgcgt ccggccgggt gggggcacgc tgtcgcgggt agggtcccgc ggaagcacga
    16681 acacggaggt gaggaccacc atgaccgcct cgacgacgca gcgccccctc agcgtcacgg
    16741 tctggaacga gaacgtccac gagaccacgg aacccgaggt ccgcgcccgc tacccccagg
    16801 gcatccacgg cgagatcgcg gcggccgtcc gggagcacgt gccggacgcc gacgtccgca
    16861 ccgcgaccct ggccgacccg gagcacggcc tgaccgagga ggtcctggcc gccaccgacg
    16921 tcctcacctg gtggggccac cgcgcgcacg gcgaggtggc ggacgaggtc gtggcccgcg
    16981 tgcgccggca cgtcctggcg ggcatgggcc tggtcgtgct gcactcgggc cacctgtcga
    17041 agatcttcac cacgctgctc ggtaccacct gcaacctcga ctggcgctcg ggcgaggacc
    17101 gcgaactggt gtggaccgtc gaccccacgc accccatcgc cgagggcata cccagcccgc
    17161 tgatcattcc cgaacaggag atgtacgggg agttcttcga catccccgcg cccgacgagc
    17221 tggtgttcat cagctccttc agcggcggcg aggtcttccg ctccggctgc accttccggc
    17281 gcggccacgg gcggatcttc tacttcagcc cgggcgacca ggcgtacccc gtgtaccacc
    17341 acccgggcgt ccgccgcgtg atcgcgaacg gggtccgctg ggcgaggggg cacgccgagc
    17401 agcggcggct gccggagctg caccggcgcg aggcgggctg gttcgaggga acgggccggt
    17461 gagcgcgccg ccctcgttcg ccacggtgcc gggggaagga cccctgcgcg tgctcgtggt
    17521 cggggccggc ggcatgggcc gcgcctggct gcgcacggtc gcggccgacg accgggtggc
    17581 gctcgccggt gtggtcgatc tcgacccggc gaccgcccgc cgtgccgtca cggaggaact
    17641 cggggacgtc gccgtcccgg tgggcgcctc actctccgaa gtggccgccc ggggcggtgc
    17701 ccaggccgtc atcgacgtca ccgttcccga ggcccatttg ccggtcacgc tggaagcctt
    17761 cgggctcggc ctgccggtcc tcggcgagaa gccgctggcc gccgatctcg cgcaggcgac
    17821 cgccctggtg aaggcggcgg cggacagcgg cctgctgttc atggtcagcc agtcccgccg
    17881 ctacgaccgc ggcctgtggg cgctgcggga ccgcgccgcg agcctcgggg acctcggcgt
    17941 gctgacccag gagttcttcc gggcgccgag gttcggcggt ttccgggagg cgatggacca
    18001 ccccctggtc ctcgacatgg ccgtgcacaa cttcgacgcg gcccgcttcg tgctgggccg
    18061 cgatccggtc agcgtctact gcgaggagtt caacccctcc tggagctggt accggggcgc
    18121 cgcgggcgcc accgccgtgt tcgagatgag cggcggcgtc cggttcgtct acacgggaag
    18181 ctggtgcgcg ccgggccttg agacctcgtg gaacagccgg tggcggctgt ccggggcccg
    18241 gggcagcgcc acgtgggacg gcgaggacga gcccgtgacg cagctggcgg acgacgcgcc
    18301 gggcgcggcg gtggaccacg gccctgcgcc cctgccgccg ggagcgggaa cggcgggcgc
    18361 gctcgccgag ttcgtgaccg cgctgcggac cgggcgggtg cccatggggg agtgccacga
    18421 caacctgctc agcctggcga tggtgcacgc cgccatcgcc tcctcggcgg caggcgcccg
    18481 cgtccgggtg gccgacgtgc tcgcttccgc gcgcgccgaa gcgggcatcc cggcccagtc
    18541 gccctatccg gccccggaga aaacggggag cggatttccc ggataaccgc gggccggggg
    18601 aattccgcgg gcgccgccgc acttccccgc cgcggtgagg gggcgccggg ccgtacggcc
    18661 cggcgccccc tcatggggtt cgcggttgaa cggcaggacg cggaccggcc gaccgcggaa
    18721 cgggcgggcc gagtacatcg cgatgcgcac gtgttcggcg cctatggggg ccgccactcc
    18781 attggccgta tactcccggc catggctagg aaagttgtca ctatctacac cgatgacctc
    18841 acgggcgaag acacggatga ggtcagtacc cacaccttct cgatcgatgg tgtgaactac
    18901 gagatcgacc tcgcaccgga ctccttcgac cagttcctct cggctctcgg cccgttcgtg
    18961 aacaaggcca ggaagaccgg caggacccag cgttctggga gcgctcccaa gcgcgatcgg
    19021 caaacggtcg acacggctcg tattcgccag tgggccaagg agaacggctt cgatgtgaac
    19081 gaacgcgggc gggtgccggc cagcgtccgg gaggcgtacg agcaggcgca ctgaaggcgg
    19141 gccggcccct gccgggggag aggggccggc ggcgaaaagg gcagctcgct cctgccgggg
    19201 agtgaccggg aaaacaccgc gggatacgcc gggcggcacc cgtgaacggc cgcgtcggcc
    19261 aggggagttg ccggggacct ggccggtcgg ggcccgcccg cggggtgcca ggacgtacca
    19321 ttcgcgccat gcgaagcgat ctcttctcag cggaatatca ggcccagccc ccggccgcgg
    19381 tcggcatgag tctgcaacac agccggtcca tcaagtacgt cgtcgacggt gagtgccacg
    19441 cgcgccaggg ggccatggtg gcctttcgcg gcaatctgca attcgaggtg aagtcccagg
    19501 gggtgggcaa cttcctgaag cgggccgtca ccggcgaggg gctgcccctc atggtggcca
    19561 aggggcaggg ggaggtgtgg ttcgcccaca acgcccagga ttgtttcatc atcgacctgg
    19621 agcagggcga cggcctgacc atcaacggcc gcaacgtcct gtgcttcgac tcctcactcg
    19681 ggtaccggat caagatggtc agcggtgccg gaatggccgg tggcggcttg ttcaactgcg
    19741 agttcgaggg acagggccgg atcggcctga tatcggacgg cgcgccgatc gtcatacccg
    19801 tgtcgtccca agcgcccgtc tacgtggaca ccgatgccgt cgtcggctgg tcgagcggac
    19861 tgagcagctc gatcaaccgg tcgcagagcc tgaagtccat gttccgcggc ggctccggcg
    19921 aggcgttcca actcgtgctg caaggcgagg gattcgtcat cgtccagccc agcgaggccc
    19981 agccggccgt cgagaagtga gacggacttc cgccgggcgc cggccgcgtt ccccgcgcta
    20041 gctcctgggc actccgcgcc cggcgcggtg cacgccgtgg ccgccgcggg acgggtgctc
    20101 ccgcggcggc cacggtgtgc cggtggctac gcgctctcgt cgaacgcctc ggcgacggcg
    20161 aggctgtcct cgtaggtgtg ctggcgcgtg atgagaccgt cggtcaccgt gaggtgcagg
    20221 gcgaaacggg cccggtaggc acgcttcgtc gactccgcgg tctgccggat ctcaccgagc
    20281 acgaccgcgt cctcgccgtc cacgagcacg cgttcgacct gggtgtccgc ctcgccgcgg
    20341 acgtggtgcc ccgccagctc gcggtagtgg tccgcgacgt ccgcacgcgt ggtgcggtgg
    20401 cggatccagg gcgtggcggc gcggccgtgc gcggactccg gccagtcgag cctccagtcg
    20461 acctgctccg cgtacaactc ggcgatgcgc tcgggcgggc cctcgcccag ccggacgagg
    20521 agatcctgca ccacggcgcg cgtcgcgtcc gcttcgggtt ggggggacat gggcgtcctc
    20581 tcgctgtact cgctgatcgg gctttcgtct tcggcaaccg tgcgacggtc accggagatc
    20641 gcagtctgtc aaataacaag cggcgacggg gacttcatga cacaccagcc cgctttcgac
    20701 cggacgggac cgcttgttgc tttgccgaga tcgatcaagt gcgatcatcg accggtagcg
    20761 caccagggac cagactgccg cgatgcgccg atggactcgc ggcgctcggt gccgtgcgtg
    20821 gtggcgacgg ggcgccacga cgccttcttc ccgccacgcg ttctcgcgcc ggcggtacgc
    20881 gaccggctgg gcgccgggct cagggtcgtc gacggcgcgg ggcacctggt actggacgag
    20941 aagcccgcga cggtcgccga gatggtgaac gagttgcacg ccgccgtgaa cgggccgtcc
    21001 cgtcccccgg gccagtgacc ggcggccgtg cgcgtcaccg cgagcgaccg cgcctcggca
    21061 cggcccttag cgtccgccgc cccacccgtc ggaagccgtg acctggacgg tcaggaggcc
    21121 cagggctccc tggtggtggt gacgggcgtg ccggtgcgcg cggactcgct gatcgccagc
    21181 ccgatcaggt ggtcctggca gccctccgcg agcgggtagg gctccgggcc ctgcccgcgc
    21241 gcccacgcgc ccgtgcggca cagcaggtcg acgacggcga ggtcgtcctc ggagaaggac
    21301 gcccccacgt aggcgttgcg gtacaccacc cgcccgtcga aggatatgtg gtgcagttcg
    21361 cggccctcca ggttgaggtc cgtgcccgtg gtccgcctgg tcagggagga cgtcatgggc
    21421 gtgcgcggat ccgccatgcg caccacggtg tcgtcgacga tctccccgag ggagccgcgc
    21481 accaccatgc ggcgcgcgcg caacgggttc caccactggt tgtcggtgaa gtcgtacagg
    21541 gcggtgcggc ccccgaagtc gagcagggcg agcgtcgtgg cggcctggcg cggcgccagg
    21601 tcgtccgacc agccgtcctt ggtcagcggg tcggccagcg gcgcggtgaa ggaccgcgcg
    21661 gtcaccgtgg ccggttcgaa gccggtgccg agcaggtgcc tgatcaggga caccgcgtgg
    21721 taggagtgcg tggaggacag ctgaacggac gtcacctcgc cgacggcgcc ggcctcgacg
    21781 acggcgcgcc gcgcgacgtg ccccggcatc agcgggtact gctcggcgac ttggaccagt
    21841 ccagagccgc cggccgcgcg ccacacctcg cgcagtcccg gcaggtcggc cgcgggcggc
    21901 gtctcggcga gcaccggtac gccgagcgcg acgagttccg ccgtgaccgg gccggtccgc
    21961 gaccacggca cgctcggcac cacgaactcc ggtgcgcggt cggccgcgac gagttccgcg
    22021 gcgctccgga acgcgggcac gccccaggcg gccgtcacct ccgcgccgcg cgcggccgtt
    22081 cgcgtcacca cgccggtcac cgcgagccgg tcggggagcg cccgcgccag ccgcaggaag
    22141 aactccgcgc gccagccgct gcccacgatg ccgaaacgta cggggtcctc gctcatgggc
    22201 ctcgctcctc gcgtccggcc gcgcggcggt gtccgcgcgg gcacagcggg cagggtaccg
    22261 accggccgcg ccgttcaacc gctcccgggc ggcggcccgg tgggatccgc gcgcggcggg
    22321 ccgtttgaaa gcggaggaga gtgagcttag gctaacctaa gctcgcgcga tccgcgctgc
    22381 ggccgtgcag tcaccggaac ccataaggaa tacccatgcc gtccagctcc acccgcatac
    22441 gccgtcaggc gctcgccctc ccggccgccc tcgccgcgct ggctctcgcc gtcaccgcct
    22501 gctcgggcga g
//
