LOCUS       NZ_CP084541            21194 bp    DNA     linear   CON 20-NOV-2024
DEFINITION  Streptomyces marincola strain SCSIO 64649 chromosome, complete
            genome.
ACCESSION   NZ_CP084541
VERSION     NZ_CP084541.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces marincola
  ORGANISM  Streptomyces marincola
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 6629020)
  AUTHORS   Shi,S.
  TITLE     Strepomyces indimicinicus sp. nov., an antibiotic producing
            actinomycetes isolated from the marine environment
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6629020)
  AUTHORS   Shi,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2021) Key Laboratory of Tropical Marine
            Bio-resources and Ecology, South China Sea Institute of Oceanology,
            Chinese Academy of Sciences, 164 Xingang West Road, guangzhou,
            Guangdong 510301, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. V6.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 444.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_020410765.1-RS_2024_11_18
            Annotation Date                   :: 11/18/2024 03:45:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,763
            CDSs (total)                      :: 5,689
            Genes (coding)                    :: 5,612
            CDSs (with protein)               :: 5,612
            Genes (RNA)                       :: 74
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 77
            CDSs (without protein)            :: 77
            Pseudo Genes (ambiguous residues) :: 0 of 77
            Pseudo Genes (frameshifted)       :: 21 of 77
            Pseudo Genes (incomplete)         :: 60 of 77
            Pseudo Genes (internal stop)      :: 2 of 77
            Pseudo Genes (multiple problems)  :: 6 of 77
            CRISPR Arrays                     :: 10
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:57:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4812959
            Orig. end                         :: 4834153
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP084541.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21194
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="26"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..21194
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21194
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11194](-)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11194)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     gene            complement(304..786)
                     /locus_tag="LC193_RS21250"
                     /old_locus_tag="LC193_21250"
     CDS             complement(304..786)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016469098.1"
                     /locus_tag="LC193_RS21250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_21250"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_318842176.1"
                     /transl_table=11
                     /translation="MTESAPPLASGPLGMRLLAFDRVPEDTRFDDGVPVGYSLVALWRA
                     GLLLLVHVRGRDCWELPGGGLDPDETPRQAAARELAEESGQHVAPRLLRFAGFALTSLP
                     GRDVLRGAVYRAETDAAEPFAPTAEISGIHWWDGAGPLPHGRLQTVDARLAELVGR"
     gene            complement(905..3037)
                     /locus_tag="LC193_RS21255"
                     /old_locus_tag="LC193_21255"
     CDS             complement(905..3037)
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014181003.1"
                     /locus_tag="LC193_RS21255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_21255"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_226076540.1"
                     /transl_table=11
                     /translation="MTSLRRGGKGGVFALLLVYLALLTALQIWSGHNNLTGWSGFSVLA
                     PMAAGALLSLRDTFLVGLLTVASIVIAYGGSIPGLSPGTRVVIVSAAICASALGLVICR
                     IRLNREARVSRLTIARERLTLLRVASRHVGSTLDVRRTAREVTEVAVPGFADLVTVDLF
                     DSVLRGDEPGGPDGVARRLRRVAHRSATGTGPREDVRDRGEGARPQRQDWPARGEATAL
                     ADAADPVEATAPDARARILDDAEVAAWLEANPACAAPHTRGNGRSGIAVPLRARGTTLG
                     IAMFVRHLRADPFDADDLLLAEEIGAQAAVCVDNARRYTHEHRASLTLQQSLLPRRLPE
                     VAAVEVATRYLPADSTAGVGGDWFDVIQLSGARVALVVGDVVGHGLYASATMGRLRSAV
                     RTLADIDLAPDELLTHLDDVVIRLRSETEGNDPEQTGEGTAESPAGAVGATCLYAVYDP
                     ASRICSMARAGHPAPALVRPDGRAEFVDAPAGQPLGLGGLPFEAHEVLLPEGSYLALYT
                     NGLIAREHDMERGQATLRQALSRPAPSADAVCETVLGAMLDDGQTDDIALLVARTRALD
                     AAHVATWNIPDDPTAVAHARELAERQLTVWGLPDAAFTTELVVSELVTNAIRHADGPIQ
                     LRLIREPSALICEVSDNSSTSPHLRRARAFDESGRGLFIVAHLTARWGTRHGREGKTIW
                     AELSPTPSPEALLAAG"
     gene            complement(3130..3684)
                     /locus_tag="LC193_RS21260"
                     /old_locus_tag="LC193_21260"
     CDS             complement(3130..3684)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016407 - acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Mac"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156: Chloramphenicol acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003946611.1"
                     /locus_tag="LC193_RS21260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_21260"
                     /product="sugar O-acetyltransferase"
                     /protein_id="WP_226076542.1"
                     /sec_met_domain="Mac (E-value: 1.4e-13, bitscore: 49.2,
                     seeds: 568, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGTQKERMLAGELYIADDPELAADAARAIRLTEEFNATAAADAAT
                     RRAALVALLGEVGEGTEVRPPLRVDYGTYISIGPRTFVNTGAVFLDVARITIGADVQIG
                     PNVQLLTPTHPVEPGPRREKWEAAAPITIGDNVWLGGGVIVCPGVTIGENTVVGAGAVV
                     VKDLPANVVAVGNPARVVRSV"
     misc_feature    3657..3670
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.03"
                     /tool="antismash"
     gene            3951..4544
                     /locus_tag="LC193_RS21265"
                     /old_locus_tag="LC193_21265"
     CDS             3951..4544
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431309.1"
                     /locus_tag="LC193_RS21265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_21265"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_226076543.1"
                     /transl_table=11
                     /translation="MGDVSEGLAGPPAGSVEARLAGRLAELRSERGWSLEELADRSGVS
                     RSTLSRVERAEMSPTAAMLGKLCTVYERTMSRLLSEVEREPPGPVPAGSQAVWTDAATG
                     FVRRSVSPPHAGLRGEVMEGRLREGAVITYEAPPVPGLEHHVWVLDGAVEVTVGEETHA
                     LGEGDCLRFRLWGPSGYRCPGPGDARYVLVAVLP"
     gene            4541..5266
                     /locus_tag="LC193_RS21270"
                     /old_locus_tag="LC193_21270"
     CDS             4541..5266
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025054.5"
                     /locus_tag="LC193_RS21270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_21270"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_318842177.1"
                     /transl_table=11
                     /translation="MSTEITRLDSPEDLLAHARELGALLADVVADGASIGFVAPFGAEE
                     AAAWWAARAPACGDGLTVWTARVGRLLVGTAGLVRAPQANGRHRAEVVKLMVHPGARGR
                     GVAAALLATAEQAAWESGVKLLLLDTETGSAAERLYRSAGWTKFGEVPAYAADATGTLR
                     ASSFFHKSAEAAAPSGGLRRGAGAARPGGPGDASVAAGGAGPGPLPPGAERLPSGAGPG
                     RSVPGTAGGPRDGGEALGA"
     gene            complement(5513..6559)
                     /locus_tag="LC193_RS21275"
                     /old_locus_tag="LC193_21275"
     CDS             complement(5513..6559)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019435701.1"
                     /locus_tag="LC193_RS21275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_21275"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_226076546.1"
                     /transl_table=11
                     /translation="MSVTLADVAARAGVSAATVSRVLNGNYPVAGATRTRVLRAVEELE
                     YVVNGPASALAAATSDLIGVLVNDIADPFFGIMAGAVQSEIGQATRKLAIVCNTGGSPE
                     RELTYLTLLQRQRASAVVLTGGAVEDAAHGAALATRLRRLDAAGSRVVLCGRPPLATAE
                     DGPQPLALTFDNRGGARRLTEHLLSLGHRRLGYLAGPAARTTTRHRLEGHRAAMAAAGL
                     AADAERLTTHGGYDRASGYDGTLELLRRDPDLTAILAANDTVALGVCAALRDRGLRIPQ
                     DVSVTGFDDLPFAVDAVPALTTVRLPLHDAGARAGRLALGREDAPPGGVATFHGDLMVR
                     DSTAPPRP"
     misc_feature    6614..6625
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.34"
                     /tool="antismash"
     gene            6648..7811
                     /locus_tag="LC193_RS21280"
                     /old_locus_tag="LC193_21280"
     CDS             6648..7811
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015660258.1"
                     /locus_tag="LC193_RS21280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_21280"
                     /product="Gfo/Idh/MocA family protein"
                     /protein_id="WP_226076549.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 1.5e-08, bitscore:
                     33.7, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 1.8e-25,
                     bitscore: 87.7, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTKKTVRIAMNGVTGRMGYRQHLVRSILAIREQGGVDLGDGSVI
                     WPEPVLVGRREHALREIARQHGLDPDTDVTTDLDAVLADDSIDIYFDSQITLTREAAIK
                     RAIAAGKHIYTEKPTATSLDGALALARLARDAGVKHGVVQDKLFLPGLRKLKRLIDGGF
                     FGRILSVRGEFGYWVFEGDWQPAQRPSWNYRSEDGGGIVVDMFPHWEYVLHELFGRVET
                     VQALTATHVPQRWDEQGKPYQATADDAAYGIFQLEGGIVAQINSSWSVRVNRDELVEFQ
                     VDGTEGSAVAGLRNCRVQHRSATPKPVWNPDLPATEVFREQWQEVPDNGEFDNGFKAQW
                     ELFLRHVVLDEPYTWDLLAGARGVQLAELGLASSADGRRLTVPELSL"
     gene            7825..8988
                     /locus_tag="LC193_RS21285"
                     /old_locus_tag="LC193_21285"
     CDS             7825..8988
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020131743.1"
                     /locus_tag="LC193_RS21285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_21285"
                     /product="dihydrodipicolinate synthase family protein"
                     /protein_id="WP_226076552.1"
                     /transl_table=11
                     /translation="MTNAIRLPEPGGTLRAYQPRAEPLDLAPHGAPLTSRIVFSAAHVV
                     ADPFADTTPDGPAAVDWDSTLAFRRHLWAHGLGVAEAMDTAQRGMGLDWQGAAELIRRA
                     GAEARATGGRIACGVGTDQLTGPADTAAVRAAYEEQLAVVEETGAQAILMASRALAASA
                     RGPEDYAEVYGHLLRQAAEPVVLHWLGPMFDPALTGYWGSEDLDAATDTFLGIIEAHQD
                     KVDGVKVSLLDAEREVRLRRRLPAGVRCYTGDDFNYPELIAGDEQGFSHALLGIFDPLG
                     PLAADAVRTLDTGDVAGFRKRLDPTVELSRHLFRAPTRYYKTGVVLLAWLAGHQDHFTM
                     VGGLQSARSLPHLARAYELADGLGLFPDPALARDRMAGLLATHGVTP"
     gene            9018..9827
                     /locus_tag="LC193_RS21290"
                     /old_locus_tag="LC193_21290"
     CDS             9018..9827
                     /GO_function="GO:0016853 - isomerase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009717778.1"
                     /locus_tag="LC193_RS21290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_21290"
                     /product="sugar phosphate isomerase/epimerase"
                     /protein_id="WP_226078838.1"
                     /transl_table=11
                     /translation="MTAKQLPLPELVKGLVGLGVPGVGLWREPVAEYGLAESAALVADA
                     GLTVTSLCRGGFFTAVEPAERAAALADNRAAVDEAAALGTDTLVLVSGGLPPGSRDLPG
                     ARERIADALAELGPYAAERGVRLAIEPLHPMYAADRCVVSTLAQALDLAERFPAEQVGV
                     VVDTYHLWWDDRVAEQIERAGQGGRIHCFQLADWVTPLPAGVLTGRGQLGDGAVDMRWF
                     RDAVAAAGYRGPVEVEIFNDGLWARDGQQVLAETVDRYREHVLDPAA"
     gene            complement(10001..11194)
                     /locus_tag="LC193_RS21295"
                     /old_locus_tag="LC193_21295"
     CDS             complement(10001..11194)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Pantocin_Microcin_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006132035.1"
                     /locus_tag="LC193_RS21295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_21295"
                     /product="ThiF family adenylyltransferase"
                     /protein_id="WP_226076554.1"
                     /sec_met_domain="Pantocin_Microcin_RRE (E-value: 4.1e-17,
                     bitscore: 60.5, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="ThiF (E-value: 2.1e-42, bitscore: 143.6,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVERLWKPRIKPEHTAYRTIEGDIRIGSVVFGIGAEIKDPAGWL
                     WTLTCGADGSRTEEALIGHVLAGHPELTELTADDVGDALRQLNAAGFVEDAAAARPALF
                     SDREAERYSRGLPLLRWMDLSPRTNTWEAQARLKKAAVLLIGLGGVGGVAAQALVASGV
                     GRLHCVDSDRVELSNLNRQTLYREADIGAGKVAAGVARLRALNSDVTVTGEEASVGTPG
                     DLAALLARAPGEAGAWDALLLCADRPQDIRRWTNRTCLAARLPWVDGGYRGPLVSVGVY
                     RPGRGGCWECLRAAEFERRDLRLAPGQDESLASPRMAWNPVNAVTAGLAGSLMAHAALT
                     LLTGVPPTEPGFRFGVNLMALHDTTYSRAPAREDCPACGAPGAPGARGAAGAPGAPA"
     aSDomain        complement(10889..11173)
                     /aSDomain="Pantocin_Microcin_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing E1-like protein in a
                     pantocin/microcin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_LC193_RS21295_Pantocin_Microcin_RRE.1
                     "
                     /evalue="2.00E-19"
                     /identifier="RREFam017.1"
                     /label="LC193_RS21295"
                     /locus_tag="LC193_RS21295"
                     /protein_end="102"
                     /protein_start="7"
                     /score="60.5"
                     /tool="antismash"
                     /translation="KPRIKPEHTAYRTIEGDIRIGSVVFGIGAEIKDPAGWLWTLTCGA
                     DGSRTEEALIGHVLAGHPELTELTADDVGDALRQLNAAGFVEDAAAARPA"
     misc_feature    complement(11177..11179)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            11406..12743
                     /locus_tag="LC193_RS21300"
                     /old_locus_tag="LC193_21300"
     CDS             11406..12743
                     /GO_function="GO:0004181 - metallocarboxypeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136116.1"
                     /locus_tag="LC193_RS21300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_21300"
                     /product="M14 family zinc carboxypeptidase"
                     /protein_id="WP_226076557.1"
                     /transl_table=11
                     /translation="MKSSTGYPSVDTLGRIARGMVRRHPRAMRLRTVGRSRGGDPLLLL
                     TVGHGARNVLLVAGAHANEPVGGATSLRLAHKLATGATGAGGTTGTGGRVADGRGLFDL
                     SRASWHFLLCLDPDGARLNESWLHGPPDLHRYFRGFYRPLFASQPEFLPMPDDGRPRLP
                     ESETLLALLDELRPEIQFSLHGSEMGGAFVQSTRGIPGLSGALRDVSGSLSIPVDIRPF
                     DGIDWHAAGPGVLVLPEPGDGRERDPSGLTTGTTWLYPARHGTATVILEVPAWAVAAVA
                     DPAPHPDPEKAVALAAESLLERIGRVAALVGEPGTLRGGEPDPFLRAVAELVAVAPGVV
                     DTWLRPDFRYADGTRPAATRGSAAALLIAARRVALRAAAMLARSPHAAPAERRARAGRA
                     AGPGELVAEWCGELAAEFGPRPVPVAVQAEFQARLALRCARLSAGG"
     gene            12819..13328
                     /locus_tag="LC193_RS21305"
                     /old_locus_tag="LC193_21305"
     CDS             12819..13328
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060960.1"
                     /locus_tag="LC193_RS21305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_21305"
                     /product="DUF3830 family protein"
                     /protein_id="WP_226076560.1"
                     /transl_table=11
                     /translation="MTNADDRFITVSLDKRGVSCTARLLSDRAPITCDAVWNALPLGGD
                     VYHAKYARNEIYALVPPFAPQEPPLENPTVTPIPGDLCYFTFSDTQLGTSSYGYENDAK
                     HQGRTTVVDLALFYERNNLLINGDAGWVPGIVWGTVVDGLDRMADACQDLWRAGALGES
                     LNFRRA"
     gene            complement(13377..14816)
                     /locus_tag="LC193_RS21310"
                     /old_locus_tag="LC193_21310"
     CDS             complement(13377..14816)
                     /EC_number="3.5.1.4"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1105: amidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020138904.1"
                     /locus_tag="LC193_RS21310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_21310"
                     /product="amidase"
                     /protein_id="WP_226076561.1"
                     /transl_table=11
                     /translation="MTDLCSLTALELTARYAAGGLSPVEVTEAALARAEAVQPVVNAFV
                     FTDPEGALAQARAAEERWARGAPAGPVDGVPVTVKDILLQRGHPTRRGSAALPAGSGPW
                     EEDAPAVARLRESGAVFLGKTTTPEFGWKGVTDAPLSGATGNPYAPERTSGGSSGGSAA
                     AVALGAGPLSLGTDGGGSVRIPAAFCGVFALKPTYGRVPLYPASAFGTLAHVGPMTRDA
                     ADAALLLDVIAHPDARDWSHLAPGGVPFTEALVPGAEGLAGLRVAWSPTMGGVVVAPDV
                     AAVTREAVERLAALGAEVTETDPPLPPLPEVRAAFQTLWFSGAARVTQHFDEAQRAAMD
                     PGLREVVSAGARFGALDYLEAVDLRMAMGRRMGAFHEEFDLLVTPTLPITAFGRGVEVP
                     DGSGLTRWTEWTPFTYPFNMTQQPAASVPCGTGADGLPVGLHLIGARHADALVLRAAHA
                     LYETGVAGVPAPALAASAPGA"
     gene            complement(14816..15784)
                     /locus_tag="LC193_RS21315"
                     /old_locus_tag="LC193_21315"
     CDS             complement(14816..15784)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091369.1"
                     /locus_tag="LC193_RS21315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_21315"
                     /product="D-2-hydroxyacid dehydrogenase"
                     /protein_id="WP_226076562.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 1.2e-47, bitscore:
                     159.9, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEARVLVLDAQPPPRLDRLAGRAHVLHSDESSLHGLLPEADVLL
                     VWDFTSDAVRAAWPGPGPRPRWVHTASAGVDRLLFPELLESEAVVTNARGVFDRPIAEY
                     VAGLVLAMAKDFRRSLEFQREHRWQHRETDKVFGSRAVVVGSGPIGRRIGTTLGALGVT
                     VRLVGRTARPADPDFGRVHAGEELPALLPDADWVVCAAPLTPRTTGMFDAAAFALMKPT
                     ARFINVGRGAHVVQDDLVAALRAGRIAGAALDVFATEPLPATSPLWDLPDLIISPHMCG
                     DTHGWRDDLADQFLDNFDRWVAGEPLANVVDKHLGYVPAEG"
     gene            15940..16767
                     /locus_tag="LC193_RS21320"
                     /old_locus_tag="LC193_21320"
     CDS             15940..16767
                     /GO_function="GO:0036361 - racemase activity, acting on
                     amino acids and derivatives [Evidence IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019357060.1"
                     /locus_tag="LC193_RS21320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_21320"
                     /product="aspartate/glutamate racemase family protein"
                     /protein_id="WP_226076563.1"
                     /transl_table=11
                     /translation="MDVSFLGGPLPQRGIGVVAPFDFALDRELWRWVPDDVSLHLTRTP
                     FVPVEVSLDLARLVSEHETLREAVRALSAVSPEVVAYACTSGSFVGGVAGERAMSAAMR
                     QAGELPALTTSGALLGALNELGARRVAVVTPYTKSVTDSLEDYLKEAGIQVCGRSYLGL
                     TREIWRVAYRDVVAMAREAVAEGPEALFISCTNLPTYDVIPQLEAELRMPVISANQVTM
                     WSALRSIGKEAVGPYQALLDPVARRGPASMTSEAGGQEVAPAVPPPAFPDEEV"
     gene            16775..17536
                     /locus_tag="LC193_RS21325"
                     /old_locus_tag="LC193_21325"
     CDS             16775..17536
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003986905.1"
                     /locus_tag="LC193_RS21325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_21325"
                     /product="decarboxylase"
                     /protein_id="WP_226076564.1"
                     /transl_table=11
                     /translation="MTATVGFLYPGHSAEDDFPRMERLLNDAGAGVLLPLVHTDIGTDA
                     HRVDALLEMGSVDRLTAGLDEVAARGAQAVVWACTSASFVFGWDGAADQVRRLAAHAGL
                     PASSTSFAFARAARAMGVTRVAVAATYPDDVAGLFGDFLKAAGVEVTGVRGSGIITAAE
                     VGTWGREEVLRLLREGDDPAADAVLLPDTALHTAAWLPELEAVAGKPVLTANQVTAWEG
                     LRLLGHTPVCPALGGLFAAPRPVGTVGAEGS"
     gene            complement(17726..18079)
                     /locus_tag="LC193_RS21330"
                     /old_locus_tag="LC193_21330"
     CDS             complement(17726..18079)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LC193_RS21330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LC193_21330"
                     /product="hypothetical protein"
                     /protein_id="WP_226076565.1"
                     /transl_table=11
                     /translation="MAESIPLDRFLRLLADESVPVVHRALWALLWESDVRVLDLLALEV
                     SDESRIRPRAGGELGGQAEALLARLVAGRASGPLFAVGGRTLSWDEAVRTAGAAGVPIH
                     AFRTSGRQHRGAL"
     gene            complement(18217..19971)
                     /locus_tag="LC193_RS21335"
                     /old_locus_tag="LC193_21335"
     CDS             complement(18217..19971)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025: diguanylate cyclase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003990467.1"
                     /locus_tag="LC193_RS21335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_21335"
                     /product="bifunctional diguanylate
                     cyclase/phosphodiesterase"
                     /protein_id="WP_226076566.1"
                     /transl_table=11
                     /translation="MNGPHETPGHDPGSAHQANPPSLTESDLLRDYRAAFQIAQFPMAL
                     VGAAGQILAANAAFGLLLGVEPERLAGVRADAVAGLGLDGRTRGSYHAVLRGHSDHMRC
                     TRRLKHADGHSLWAEVTVLPTPTESSAALLTVLDISERRALQERLRHIQMHDPVTRLPN
                     RALFFERLTAALSDSATGRIGLCQVGIDGFKAVNDTLGHRVGDELLGAAGQRLAECATG
                     AGGHLVARLGGDEFAVLVEGSTGTEQLTELAETMLAALQRPFDLAGQRLAVSASIGVVE
                     RESATTTATGLMQAADTTLYWAKADGKARWTLFDPERNAHRMTRQSLSSTLRRGVDRGE
                     FTLEYQPIVGLADDIVRGAEALVRWRHPQFGTLGPDRFIGLAEENGAIVPLGRWILGEA
                     CRQARRWQVEHPGPPLFVSVNVAVRQVWDSDLVSDVAKALDDSGLPSGLLQLELTESAV
                     MGSAGRPLQALQALADMGVRIAIDDFGTGYSNLAYLSRLPVRALKLDGMFVRGFRTARH
                     LNPADETIVSSLVQLAHKLGLTVTAECVEGPAQAERLRRIGCDTGQGWHYARPMSPDHL
                     ADLLAGRD"
     misc_feature    complement(20113..20128)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.35"
                     /tool="antismash"
     misc_feature    complement(20980..20995)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.83"
                     /tool="antismash"
ORIGIN
        1 cggcggcggc cgtgatcacc gtgatcgcgg acgtcgccgc gttcatcctc ggtctgtgga
       61 tcgtcatgta cctcctcgac gccaacgagc agaacggact ggtcgagttc gtccacgacg
      121 tgtcccgctg gctggccacc tggtcgcacg acctgttcac gttcgacgag gagtgggcgc
      181 gcgtcgtctg cggttacggg ctcgcggccg tggtgtacct cgtcgtcggc cacgccgtgg
      241 ccaaccgcgt ccggcgcctg tgagggaacg cggcgacggc aggacgcgag ccggtgccac
      301 cggtcagcgg ccgaccagct ccgcgaggcg ggcgtcgacc gtctggaggc ggccgtgcgg
      361 caacgggccg gccccgtccc accagtggat acccgatatc tccgccgtcg gggcgaacgg
      421 ctccgccgcg tccgtctccg cgcggtagac cgcgccgcgc agcacgtcgc ggccgggcag
      481 cgaggtcagc gcgaacccgg cgaagcgcag cagccgcggc gccacgtgct gccccgactc
      541 ctccgccagc tcgcgcgccg cggcctgacg cggcgtctcg tccgggtcga gcccgccgcc
      601 gggcagctcc cagcagtccc ggccgcgcac gtgcaccagg agcagcagcc cggcgcgcca
      661 cagggccacc aggctgtagc ccacggggac gccgtcgtcg aagcgcgtgt cctcgggcac
      721 gcggtcgaac gcgagcagcc gcatgccgag cggtcccgag gcgagcggtg gggcggattc
      781 ggtcatggcg gcagcctagg cgccgcctcc gacaacgcgc cccgcccggg ttcgtcccgg
      841 ccggtccggt ccgttcctgc gtgccgtcgc gccgtcgtgc cgttccgccg ggccggggcg
      901 ccgttcagcc ggcggcgagc agcgcctcgg gggagggggt cggtgacagc tcggcccaga
      961 tggtcttccc ctcccgcccg tgcctggtgc cccaccgtgc ggtcaggtgc gcgacgatga
     1021 acagcccgcg cccgctctcg tcgaaggccc gggcccggcg caggtggggc gaggtgctgc
     1081 tgttgtccga gacctcgcag atcagcgcgg agggctcccg gatgaggcgc agctggatcg
     1141 gcccgtcggc atgcctgatg gcgttggtga ccagctcgct gacgacgagc tccgtggtga
     1201 aggccgcgtc cgggagtccc cagacggtca actgccgttc ggcgagttca cgcgcatgag
     1261 cgacggcggt ggggtcgtcg gggatgttcc acgtggcgac gtgcgccgcg tcgagggcac
     1321 gggtacgggc cacgaggagc gcgatgtcgt ccgtctgccc gtcgtccagc atcgccccga
     1381 gcaccgtctc gcagaccgcg tcggcggagg gggcgggccg ggacagggcc tgtctgagcg
     1441 tcgcctggcc gcgttccatg tcgtgctcgc gggcgatgag cccgttggtg tagagcgcga
     1501 ggtagctgcc ttcgggaagc aggacctcgt gcgcctcgaa cggcagcccg ccgaggccga
     1561 gcggctgccc ggcgggcgcg tccacgaact ccgcccgccc gtcaggacgc accagcgcgg
     1621 gcgcggggtg cccggcgcgc gccatgctgc aaatgcggga cgccgggtcg tagacggcgt
     1681 acaggcaggt ggcgccgacc gcgccggccg ggctctccgc ggtgccctcg cccgtctgct
     1741 ccgggtcgtt cccctcggtc tcggaacgca gccggatgac gacgtcgtcg aggtgggtga
     1801 gcagttcgtc gggcgccagg tcgatgtccg cgagcgtgcg caccgcggac cgcagccgtc
     1861 ccatggtcgc cgaggcgtac aggccgtgcc cgaccacgtc gccgacgacg agggccaccc
     1921 gcgcgccgga gagctggatg acgtcgaacc agtcgccgcc cacgcccgcg gtcgagtccg
     1981 ccggcaggta gcgggtggcc acctcgacgg ccgcgacctc gggcagccgc cggggcagca
     2041 ggctctgctg gagggtgagc gaggcgcggt gctcgtgggt gtagcggcgc gcgttgtcga
     2101 cgcacaccgc cgcctgcgcg ccgatctcct cggccagcag gaggtcgtcg gcgtcgaagg
     2161 ggtcggcgcg caggtgccgg acgaacatcg cgatccccag cgtggtgccc cgggcgcgca
     2221 gcggaacggc gatgccggaa cggccgttgc cgcgcgtgtg cggggccgcg cacgcggggt
     2281 tcgcctccag ccacgcggcc acttcggcgt cgtcgaggat gcgggcgcgc gcgtcgggcg
     2341 cggtcgcctc gaccgggtcc gcggcgtcgg cgagggcggt cgcctccccg cgcgcgggcc
     2401 agtcctggcg ttggggccgc gcgccctcgc cccggtcccg cacgtcctcg cgcgggccgg
     2461 tgccggtggc cgagcggtgc gccacgcgcc gcaggcgccg tgcgacgccg tcgggcccgc
     2521 cgggctcgtc cccgcgcagg accgagtcga acaagtcgac cgtgaccagg tcggcgaagc
     2581 ccggtaccgc gacctcggtg acctcgcgcg ccgtgcgtcg cacgtcgagc gtgctgccga
     2641 cgtgccggct cgccacgcgc agcagcgtca gccgctccct cgcgatggtc aggcggctca
     2701 cgcgggcctc gcggttcagc cggatgcggc agatcacgag gccgagggcg gacgcgcaga
     2761 tcgcggccga gacgatgacg acgcgggtgc cgggggagag gccggggatg ctgccgccgt
     2821 acgcgatgac gatggaggcc accgtcagca ggccgacgag gaacgtgtcg cgcagggaca
     2881 gcagcgcgcc cgccgccatc ggggccagca ccgagaaccc cgaccatccg gtgaggttgt
     2941 tgtgtcccga ccagatctgg agggcggtga gcagcgccag gtagacgagc agcagcgcga
     3001 acacgccgcc tttgcccccg cggcgcaggg aagtcacgtg gcgcacctcc cgccttctgt
     3061 ggccctctcg gtcaaccgta gccgcggggg ttgccccccg cgaccggcgg ccgtaccgtg
     3121 cccggccgcc tacacgctcc ggacgacgcg ggccggattg cccacggcga cgacgttcgc
     3181 gggcaggtcc ttgacgacca cggcacccgc tcccaccacg gtgttctcgc cgatggtcac
     3241 accggggcag acgatgacgc cgccgccgag ccacacgttg tcgccgatgg tgatgggcgc
     3301 cgcggcctcc cacttctcac ggcgcggtcc tggctcgacc ggatgggtgg gggtgagcag
     3361 ctggacgttc gggccgatct gcacgtcggc gccgatggtg atgcgggcga catcgaggaa
     3421 gacggcaccg gtgttgacga acgtgcgggg gccgatgctg atgtaggtgc cgtagtcgac
     3481 gcgcagcggg gggcgtacct cggtgccctc gccgacctcg ccgagcagcg cgacgagggc
     3541 ggccctgcgg gtggcggcgt cagccgcggc cgtggcgttg aactcctccg tcaggcggat
     3601 cgcccgggcg gcgtccgcgg cgagttcggg gtcgtcggcg atgtacagct cgcccgcgag
     3661 catgcgttcc ttctgggtgc ccatggcgcg accctagtgc tgtcggcccg gatgccaccg
     3721 gccggggcgg gggcgcggcg gcgctctgcg ccggtgcgcc cgcgcgggcc gcgcgcggcc
     3781 ctctcgtcct cgtccggctc tggcggactc gacgggctcg cggcgggttc cttcggctcg
     3841 cgcggtctcg cccggtgctg tcgccgaccc gtgcactcgt tcgggggata tccgggggcg
     3901 accgccggaa aaaccgcccg ttctcccgga tcagggatag tatcccggat atgggagatg
     3961 tgagtgaggg gctggccggt ccgccggcgg gctcggtgga ggccaggctc gcgggccggc
     4021 tcgcggagct gcggagcgag cggggctggt cgctggagga gctggccgat cgcagcggag
     4081 tcagccgttc gacgctgtcg cgcgtggagc gggccgagat gagcccgacc gccgccatgc
     4141 tcggcaagct gtgcacggtc tacgagcgga cgatgtcgcg gctgctgagc gaggtggagc
     4201 gggagccgcc gggaccggtg ccggccggca gccaggcggt gtggacggac gcggccaccg
     4261 gtttcgtgcg ccgttcggtg tcgccgccgc acgcggggct gcgcggcgag gtgatggagg
     4321 ggcggctgcg ggagggagcc gtcatcacct atgaggcgcc gcccgtcccc ggcctcgaac
     4381 accatgtgtg ggtcctcgac ggcgccgtcg aggtcacggt gggggaggag acgcacgccc
     4441 tgggggaggg cgactgcctg cggttccggc tgtgggggcc gtccgggtac cgctgccccg
     4501 ggccagggga cgcccggtac gttctggtgg cggtgctgcc gtgagcaccg agatcacccg
     4561 gctcgacagc ccggaggacc tgctggcgca cgcccgggag ctgggcgccc tgctggccga
     4621 cgtggtggcc gacggcgcct ccatcggttt cgtcgcgccg ttcggcgccg aggaggcggc
     4681 ggcctggtgg gcggcccgcg cccccgcctg cggcgacggc ctgacggtgt ggacggcgcg
     4741 ggtggggcgc ctcctggtcg gcaccgcggg gctggtccgg gcccctcagg cgaacggacg
     4801 gcaccgcgcc gaggtcgtga agctcatggt ccaccccggg gcgcgcggtc ggggcgtcgc
     4861 cgcggcactc ctcgccacgg ccgagcaggc ggcatgggag tccggggtga agctgctgct
     4921 gctcgacacg gagaccggca gcgccgccga gcgcctgtac cggtcggcgg gctggacgaa
     4981 gttcggcgag gtccccgcct acgcggccga tgcgacgggc accctgcggg cgagcagctt
     5041 cttccacaag tccgcggagg ccgccgcgcc ctcaggcggc ctccgccggg gcgcgggcgc
     5101 cgcacgcccc ggcggccccg gggacgcctc ggtcgcggcg ggcggcgccg ggccggggcc
     5161 gctcccgccc ggggcagaac ggctcccgtc cggggccggt cccggacgtt ccgtcccggg
     5221 gacagcgggc gggccgcggg acgggggtga ggccctgggc gcatgagagg acgcgggggt
     5281 gcgcgggcgg gtgacgcggg cacggtgcgt gtgcgtcccg gggcgcggcg gcggaccgtg
     5341 ccgtgcggtg gcggggagcc gttggaggtg ccgggtgccg ggtgccgggt gccgggtgcc
     5401 gggtgcggtg gcccgggtgc ggtcgcgggt cgtggtgggg cgcggtcggt gtgcccggtg
     5461 cggtcgcggt ggccggtgtg cggtggcggg cgtggggggc ccctgaggcg gttcaggggc
     5521 gcggcggcgc cgtggagtcg cgcaccatga ggtcgccgtg gaaggtggcg acgcccccgg
     5581 gcggcgcgtc ctcgcggccg agggcgagcc gtccggcccg ggcgcccgcg tcgtgcagcg
     5641 ggaggcggac cgtggtcagg gccggcacgg cgtccaccgc gaacggcagg tcgtcgaagc
     5701 cggtcacgga cacgtcctgc ggaatgcgca gcccgcggtc gcgcagggcc gcgcacacgc
     5761 cgagggccac cgtgtcgttg gcggccagga tcgccgtcag atccgggtcg cgccgcagga
     5821 gttcgagtgt gccgtcgtag ccggaggcgc ggtcgtaccc gccgtgcgtg gtgagccgtt
     5881 cggcgtccgc ggcgaggccc gccgcggcca tggccgcccg gtgcccctcc agccggtgac
     5941 gtgtcgtggt gcgggcggcc ggcccggcga ggtagccgag gcggcggtgg ccgagggaca
     6001 gcaggtgctc ggtcaggcgc cgggcgccgc cgcggttgtc gaacgtcagg gccagcggct
     6061 gcggtccgtc ctccgcggtg gccagcggcg gccggccgca cagcacgacc cgcgatccgg
     6121 ccgcgtccag ccggcgcagg cgcgtggcga gcgccgcgcc gtgcgcggcg tcctccaccg
     6181 ccccgccggt gagcacgacg gcggaggccc gctggcgctg gaggagggtg agataggtca
     6241 gctcgcgctc gggggagccg ccggtgttgc acacgatggc cagcttgcgc gtcgcctgcc
     6301 cgatctccga ctgcaccgcc cccgccatga tcccgaagaa cgggtcggcg atgtcgttga
     6361 ccaggacgcc gatcagatcg gaggtggcgg cggccagcgc gctggccggc ccgttcacca
     6421 cgtactccag ctcctcgacg gcccgcagca ccctggtcct ggtggcgccg gccacggggt
     6481 agttgccgtt gagaacgcgg gaaaccgttg ccgcggacac ccccgcgcgg gcggccacgt
     6541 ccgccagcgt gactgacatg ctctgctccc acttgtccta gccggtggag agaggttagc
     6601 ttctctccgg gtagaaagcg cttactgcgc tctctgggag ggaaggcatg accaccaaga
     6661 aaactgtccg gatcgcgatg aacggcgtca ccgggcgcat gggctaccgg cagcacctgg
     6721 ttcgttcgat cctggcgatc cgtgagcagg gcggtgtgga cctcggcgac ggctcggtca
     6781 tctggcccga gccggtgctg gtcggacgcc gcgagcacgc gctgcgggag atcgcgcggc
     6841 agcacggcct cgaccccgac accgacgtga cgaccgacct cgacgcggtg ctcgccgacg
     6901 acagcatcga catttacttc gactcgcaga tcacgctcac ccgtgaggcc gccatcaagc
     6961 gggccatcgc cgcgggcaag cacatctaca ccgagaagcc gaccgccacc tcgctcgacg
     7021 gcgcgctcgc gctggcgcgg ctggcgaggg acgcgggcgt caagcacggc gtggtgcagg
     7081 acaagctgtt cctgccgggc ctgcgcaagc tcaagcggct catcgacggc ggcttcttcg
     7141 ggcgcatcct gtcggtgcgc ggcgagttcg gctactgggt gttcgagggc gactggcagc
     7201 ccgcgcagcg cccctcctgg aactaccgct ccgaggacgg cggcgggatc gtcgtcgaca
     7261 tgttcccgca ctgggagtac gtgctgcacg agctgttcgg ccgggtggag accgtgcagg
     7321 cgctgaccgc gacgcacgtg ccccagcgct gggacgagca gggcaagccc taccaggcga
     7381 cggcggacga cgccgcctac ggcatcttcc agctcgaagg cggcatcgtc gcccagatca
     7441 actcctcgtg gtcggtgcgc gtcaaccgcg acgagctggt ggagttccag gtggacggca
     7501 ccgagggctc cgcggtcgcg ggcctgcgca actgccgggt ccagcaccgt tccgccacgc
     7561 cgaagccggt gtggaacccg gacctgcccg ccaccgaggt gttccgcgag cagtggcagg
     7621 aggtgccgga caacggcgag ttcgacaacg ggttcaaggc gcagtgggag ctgttcctgc
     7681 ggcacgtggt gctcgacgag ccgtacacct gggacctgct ggccggggcg cgcggcgtgc
     7741 agctggccga gctggggctc gcctcctcgg cggacggccg gcggctgacc gttcccgagc
     7801 tgagcctgtg aaggaggacc gaccgtgacg aacgccatcc ggcttccgga gcccggcggc
     7861 acactgcgcg cgtaccagcc gcgcgccgaa cccctcgacc tcgcaccgca cggtgccccg
     7921 ctcacctcgc gcatcgtgtt ctcggccgcg cacgtggtcg ccgacccgtt cgccgacacc
     7981 acgcctgacg gcccggcggc ggtggactgg gacagcacgc tggccttccg ccgccacctg
     8041 tgggcgcacg gcctcggcgt cgccgaggcc atggacaccg cccagcgcgg catgggtctg
     8101 gactggcagg gggcggccga gctgatccgc cgcgcgggcg ccgaggcgcg cgcgaccggc
     8161 gggcgcatcg cgtgcggcgt cggcaccgac cagctgaccg gcccggcgga caccgcggcg
     8221 gtgcgggcgg cctacgagga gcagctcgcg gtcgtcgagg agacgggtgc ccaggcgatc
     8281 ctgatggcct cgcgggcgct ggccgcgtcg gcgcgcggcc ccgaggacta cgcggaggtc
     8341 tacgggcacc tgctgcggca ggcggcggag ccggtggtgc tgcactggct cggccccatg
     8401 ttcgacccgg ccctcacggg ctactggggc agcgaggacc tcgacgcggc caccgacacg
     8461 ttcctcggca tcatcgaggc ccaccaggac aaggtggacg gggtcaaggt gtcgctcctc
     8521 gacgcggaac gcgaggtgcg gctgcggcgg cggctgccgg cgggcgtgcg ctgctacacc
     8581 ggtgacgact tcaactaccc ggagctgatc gccggcgacg agcagggctt cagccacgcg
     8641 ctgctcggga tcttcgaccc gctcggcccg ctggccgccg acgcggtgcg gacgctggac
     8701 accggcgatg tcgcgggctt ccgcaagcgg ctcgacccca cggtggagct gtcgcggcac
     8761 ctgttccggg cgccgacccg ctactacaag acgggcgtgg tcctcctggc ctggctggcc
     8821 gggcaccagg accacttcac gatggtcggc gggctccagt ccgcgcggtc gctgccgcac
     8881 ctcgcgcgtg cctacgaact ggccgacgga ctgggcctgt tccccgaccc cgccctggcg
     8941 agggaccgca tggcggggct cctggcgacg cacggggtga cgccgtgagc gatctgaccg
     9001 ggttctccat caaccagatg acggccaagc agctgccgct gcccgagctg gtcaagggcc
     9061 tcgtcggcct cggcgtgccg ggcgtcggcc tgtggcgcga gccggtcgca gagtacgggc
     9121 tcgcggagtc ggccgcgctg gtcgccgacg ccgggctgac cgtcacctcg ctgtgccgcg
     9181 gcggattctt cacggccgtc gagccggcgg agcgggcggc ggcgctggcc gacaaccggg
     9241 ccgccgtgga cgaggccgcc gcgctcggca cggacaccct cgtactggtc tccggcgggc
     9301 tgccgcccgg cagccgtgac ctgccgggcg cgcgcgagcg gatcgcggac gcgctggccg
     9361 agctggggcc gtacgcggcc gagcgcggcg tgcggctggc gatcgagccg ctgcacccga
     9421 tgtacgcggc ggaccggtgc gtcgtctcga cgctcgcaca ggcgctcgac ctcgcggaac
     9481 gcttccccgc cgagcaggtg ggcgtcgtcg tggacaccta ccacctgtgg tgggacgacc
     9541 gggtcgccga gcagatcgaa cgggccgggc agggcggtcg catccactgc ttccagctcg
     9601 ccgactgggt cacacccctg cccgccgggg tcctcaccgg gcgcgggcag ctcggggacg
     9661 gcgcggtgga catgcgctgg ttccgcgacg ccgtcgccgc cgcggggtac cgcggtcccg
     9721 tggaggtgga gatcttcaac gacggcctgt gggcgcggga cgggcagcag gtgctcgccg
     9781 agaccgtgga ccgctaccgg gagcacgtgc tggacccggc cgcctgacga acggcccgcc
     9841 gccgcgccgc accaccgcgg cggcggcccg ttcggacacc gggcaccgga tgccgcacgc
     9901 ggcacgcggt ggccgcgccg ggcgtcgtcg acgcgacgga gcggcccgcg gccgggccgg
     9961 gacgcggttc ggcccggcgg aggcgttcgg gccgaggggg tcaggccggg gcgcccggtg
    10021 ccccggcggc gccccgggcc ccgggggcgc cgggcgcccc gcaggcgggg cagtcctccc
    10081 gggccggggc ccgggagtac gtcgtgtcgt gcagcgccat caggttgacg ccgaagcgga
    10141 acccgggctc ggtcggcggg accccggtca gcagggtcag cgccgcgtgc gccatcagac
    10201 tgccggcgag gcccgcggtg acggcgttca ccgggttcca cgccatgcgc ggggaggcca
    10261 gcgactcgtc ctgtcccggc gcgaggcgca ggtcccgccg ctcgaactcg gccgcccgca
    10321 ggcactccca gcatccgccg cggcccggcc ggtacacgcc gacgctgacc agcgggccgc
    10381 ggtagccgcc gtcgacccag ggcaggcgcg cggccaggca cgtgcggttc gtccaccgcc
    10441 tgatgtcctg cggccggtcg gcgcacagca ggagcgcgtc ccaggccccg gcttccccgg
    10501 gcgcccgggc cagcagcgcc gccaggtcgc ccggcgtgcc cacgctggcc tcctcaccgg
    10561 tcaccgtgac gtcggagttc agcgcccgca ggcgcgcgac gcccgccgcg accttgccgg
    10621 cgccgatgtc cgcctcgcgg tacagcgtct gccggttgag gttggacagc tcgacccggt
    10681 cggagtcgac gcagtgcagg cgcccgacgc cggaggcgac cagcgcctgg gccgccaccc
    10741 cgccgacccc gccgaggccg atcagcagca ccgcggcctt tttgagccgg gcctgggcct
    10801 cccaggtgtt cgtacggggc gacaggtcca tccagcgcag cagcggaagg ccgcggctgt
    10861 accgttccgc ctcgcggtcg gagaagaggg cggggcgcgc cgccgcggcg tcctcgacga
    10921 agccggcggc gttcagctgc cgcagcgcgt cgccgacgtc gtccgccgtc agctccgtca
    10981 gctccgggtg gccggccagg acgtggccga tcagcgcctc ctcggtgcgg ctgccgtccg
    11041 cgccgcaggt gagggtccac agccagcccg cggggtcctt gatctcggcg ccgattccga
    11101 agacgacgct gccgatacgg atgtctccct cgatggtgcg ataagcggtg tgctcgggct
    11161 tgatccgcgg cttccataac cgttcaacgg ccatatgttc ctgcccaatt gactggtccg
    11221 acccttgaca ctctgccccg accggcgaac acttgcaagc agacgtcagg ccatagaagg
    11281 gggcggcatg acccgtatcg agatacgacc gctggaaaag aaggagacca cgggggagag
    11341 caactccatc ggtacgtaat cgcgtccggc gccgcgccgc ccacagactt ggaatccagg
    11401 tgtcgttgaa gagcagcacg ggttacccat cggtcgacac cctgggccgg atcgcgcgcg
    11461 gcatggtgcg gcgccatccg cgggccatgc ggctgaggac ggtgggacgc tcgcgcgggg
    11521 gcgacccgtt gctgctcctc acggtcggcc atggcgcgcg caacgttctc cttgtcgccg
    11581 gagcacacgc caacgagcct gtgggcgggg cgacttcact acgactggcg cacaagttgg
    11641 ccaccggtgc gaccggtgcc ggagggacga ccggtacggg cgggcgggtg gccgacgggc
    11701 gggggctgtt cgatctgtcg cgcgcctcct ggcatttcct gctgtgtctc gacccggacg
    11761 gcgcccggct gaacgagagc tggctgcacg gaccgcccga cctccatcga tatttccgtg
    11821 gattctaccg gccgctgttc gcgagccagc cggaattcct gcccatgccg gatgacgggc
    11881 gcccgcggct gcccgaatcg gaaaccctgc tcgctttgct cgacgagctg cgcccggaga
    11941 tccaattctc cctgcacgga agtgaaatgg gcggcgcatt cgtgcagagt acgcgcggta
    12001 ttcccgggct cagcggcgcg ctgcgcgatg tgtccgggtc cctgtccatt cccgtggaca
    12061 tccgcccgtt cgacggaatc gactggcacg cggcgggccc tggcgtcctc gtcctgcccg
    12121 agccggggga cggccgcgaa cgcgacccct cggggctgac caccgggacc acgtggctgt
    12181 acccggcgcg ccacggcacg gcgaccgtga tccttgaggt cccggcctgg gccgtcgccg
    12241 ccgtcgccga ccccgcgccc caccccgacc cggagaaggc cgtcgcgctg gccgcggaga
    12301 gcctgctcga acgcatcggc cgcgttgccg ccctggtcgg ggagccgggg acgctgcgcg
    12361 gcggggagcc cgacccgttc ctgcgggccg tggccgaact ggtcgccgtc gcgcccggcg
    12421 tcgtcgacac ctggctgcgc cccgacttca ggtacgccga cggaacgcgg cccgcggcca
    12481 cgcgcggcag cgccgccgcc ctgctgatcg ccgcccgccg cgtcgcgctg cgcgcggcgg
    12541 cgatgctcgc caggtcgccg cacgccgccc cggcggaacg gcgggcgcgc gcggggcgtg
    12601 ccgcgggccc cggggagctg gtggcggagt ggtgcgggga actggcggcc gagttcgggc
    12661 cgcgccccgt gcccgtcgcc gtgcaggccg agttccaggc ccgcctcgcg ctgcgctgcg
    12721 cccgcctgtc cgccggcggg tgacgaacgc gccgccgcgc cgcggccctt cggcgtggca
    12781 tggtgggttc ggcccgcccc accaccagga gggaacccat gacgaacgcc gacgaccggt
    12841 tcatcaccgt ctcgctcgac aagcgcgggg tcagctgcac cgcccggctg ctgagcgacc
    12901 gcgcgccgat cacgtgcgac gccgtgtgga acgcgctgcc gctgggcggc gacgtctacc
    12961 acgcgaagta cgcgcgcaac gagatctacg cgctggtgcc gccgttcgcg ccgcaggaac
    13021 cgccgctgga gaacccgacg gtcacgccga tccccggcga cctgtgctac ttcacgttct
    13081 ccgacaccca gctcggcacc agctcctacg ggtacgagaa cgacgcgaag caccagggcc
    13141 gcacgacggt ggtggacctg gcgctgttct acgagcgcaa caacctgctg atcaacggcg
    13201 acgcgggctg ggtgcccggc atcgtctggg gcaccgtggt ggacggcctc gaccgcatgg
    13261 cggacgcctg ccaggacctg tggcgggccg gcgccctcgg cgagagcctg aacttccgcc
    13321 gcgcgtgagt ccttcacccg ggcgcgcccc gcgcgcccgg gcggaaggac ctgcggtcag
    13381 gcgcccggcg cgctcgccgc gagcgccggc gccggaacgc ctgccacgcc cgtctcgtac
    13441 agggcgtgcg cggcgcgcag gaccagcgcg tccgcgtgcc gcgcgccgat cagatgcagc
    13501 ccgaccggca gcccgtccgc gccggtgccg cacggcaccg aggccgcggg ctgctgcgtc
    13561 atgttgaacg gataggtgaa cggcgtccat tccgtccacc gggtcagtcc cgagccgtcc
    13621 ggcacctcga cgccccgccc gaacgccgtg atcggcagcg tcggcgtcac cagcaggtcg
    13681 aactcctcgt ggaacgcgcc catccgccgc cccatggcca tccgcaggtc gaccgcctcc
    13741 aggtagtcga gcgccccgaa ccgcgccccg gcgctcacga cctcgcgcag ccccgggtcc
    13801 atcgcggccc gctgcgcctc gtcgaagtgc tgggtcacgc gggccgctcc ggagaaccac
    13861 agcgtctgga acgcggcgcg cacctccggc agcggcggca gcggcggatc ggtctcggtg
    13921 acctcggcac cgagcgcggc cagccgttcc accgcctccc gcgtcaccgc ggccacgtcg
    13981 ggtgccacga cgaccccgcc catggtgggg gaccaggcga cgcgcagccc cgcgagaccc
    14041 tcggcgcccg gcaccagcgc ctcggtgaac ggcacgcccc cgggggcgag gtgggaccag
    14101 tcgcgcgcgt ccgggtgggc gatcacgtcg agcagcaggg ccgcgtcggc cgcgtcccgc
    14161 gtcatcggtc cgacgtgcgc gagggtgccg aaggcgctcg ccgggtacag cggcacccgg
    14221 ccgtaggtgg gcttcagcgc gaagacgccg cagaacgcgg ccgggatccg caccgacccg
    14281 ccgccgtccg tccccaggct caacgggccg gcgcccagcg cgaccgcggc ggcgcttccg
    14341 ccgctcgacc cgccggaggt gcgctccggc gcgtacgggt tgccggtcgc gccggacagc
    14401 ggcgcgtcgg tcacgccctt ccagccgaac tcgggcgtgg tggtcttgcc gaggaacacg
    14461 gcgcccgact cccgcagccg cgcgaccgcg ggcgcgtcct cctcccacgg tcctgagccg
    14521 gcgggcaggg ccgcggagcc gcggcgcgtg ggatggccgc gctggagcag gatgtccttc
    14581 accgtcacgg gaacgccgtc cacgggaccg gcgggcgcgc cgcgcgccca gcgttcctcg
    14641 gcggcgcgcg cctgcgcgag cgccccctcg gggtcggtga acacaaaggc gttcaccacc
    14701 ggctggaccg cctcggcccg ggcgagggcc gcctcggtca cctcgacggg ggagaggccg
    14761 ccggccgcgt agcgcgcggt cagttcgagc gcggtcaggg aacacagatc ggtcatcagc
    14821 cctccgcggg gacgtagccc agatgtttgt cgacgacgtt ggccagcggt tcgcccgcca
    14881 cccagcgatc gaagttgtcg aggaactgat ccgcgaggtc gtcgcgccag ccgtgggtgt
    14941 cgccgcacat gtgcggcgaa atgatcagat ccggaaggtc ccacagcgga ctcgtggccg
    15001 gcagcggctc ggtcgcgaac acgtccaggg cggctcccgc gatccggccg gcgcgcagcg
    15061 cggccacgag gtcgtcctgc acgacgtgcg cgccgcgacc gacgttgatg aagcgcgcgg
    15121 tgggcttcat gagcgcgaag gccgccgcat cgaacatgcc cgtggtccgc ggggtcaggg
    15181 gcgcggcgca gaccacccag tcggcgtccg gcagcagcgc gggcagctcc tcgcccgcgt
    15241 gcacccggcc gaagtcgggg tcggccggcc tcgcggtccg gccgaccagg cgcaccgtca
    15301 cccccagcgc gcccagcgtc gtcccgatgc gccggccgat gggtcctgaa ccgacgacaa
    15361 cggcccggct gccgaacact ttgtccgttt cccggtgctg ccagcggtgt tcgcgctgga
    15421 actcaaggct gcgccggaaa tccttggcca tggccaggac gagtccggcc acgtattcgg
    15481 cgatcggccg gtcgaacaca ccgcgggcgt tcgtcaccac cgcttcggat tcgagcagtt
    15541 cgggaaagag cagccggtcc acaccggcgc tcgcggtgtg gacccagcgc ggtcgcggcc
    15601 cgggacccgg ccacgccgcg cgcaccgcgt cggacgtgaa gtcccacacg agcaggacgt
    15661 ccgcctcagg caacaggccg tgcagcgaac tctcatcact gtgcagcacg tgcgcccggc
    15721 ccgcaagccg gtcgagtcgg ggcgggggtt gtgcgtcgag gacgagcaca cgggcttctg
    15781 acatgagggg gaaaccgttc cgcaacgagg ctttgtttgg ctggaagtca tggattgacc
    15841 acggtaggaa ctcgtatcta ccttcgtcaa tgaaggcatc tgctctttct gctcttacat
    15901 ccctcccggt attcccggcc cgttgaagcg gggttcgaca tggatgtctc ctttttgggt
    15961 ggcccgctcc cgcagcgggg catcggagtc gtcgcaccat tcgatttcgc gctcgaccgc
    16021 gaactgtggc ggtgggtgcc cgatgacgtc tcgctgcacc tgacgcggac gccgttcgtc
    16081 ccggtcgagg tcagtctcga cctggcgcgg ctggtcagcg agcacgagac gctgcgcgag
    16141 gcggtccgcg cgctgtcggc ggtcagtccc gaggtggtgg cctacgcgtg cacctcgggc
    16201 agtttcgtcg gcggcgtcgc cggcgaacgc gccatgtccg ccgccatgcg gcaggccggc
    16261 gagctgccgg cgctcaccac gtcgggcgcc ctgctcggcg ccctgaacga gctgggcgcg
    16321 cgccgggtcg ccgtggtcac gccgtacacg aagtcggtga cggactcgct tgaggactac
    16381 ctcaaggagg cgggcatcca ggtctgcggg cgcagttacc tgggcctgac cagggagatc
    16441 tggcgggtgg cgtaccggga cgtggtcgcc atggccaggg aggcggtggc cgaggggccc
    16501 gaggcgctgt tcatcagctg caccaacctg cccacctacg acgtcatccc gcagctggag
    16561 gccgagttgc ggatgccggt gatctcggcg aaccaggtga cgatgtggtc cgcgctgcgg
    16621 tccatcggca aggaggccgt cggcccctac caggcgctgc tcgacccggt ggcccggcgg
    16681 ggccccgcgt cgatgacgtc cgaggccggc ggccaggaag tggcaccggc ggtaccgccg
    16741 ccggcattcc ccgacgagga agtgtgagac ccgtatgacc gcgacggttg gattcctgta
    16801 cccgggacac tcggcggagg acgacttccc ccgcatggaa cgcctgctga acgacgcggg
    16861 cgccggtgtc ctgctgcccc tggtgcacac cgacatcggc acggacgccc accgggtgga
    16921 cgcgctgctt gagatgggct cggtcgaccg gctcacggcg ggactcgacg aggtggccgc
    16981 gcggggcgcg caggccgtgg tgtgggcgtg caccagcgcg agtttcgtct tcggctggga
    17041 cggcgcggcc gaccaggtgc ggcgcctcgc cgcgcacgcg ggcctgccgg cgtcgagcac
    17101 gtcgttcgcg ttcgcccgtg ccgcgcgcgc catgggcgtc acccgggtgg ccgtcgcggc
    17161 gacgtacccc gacgacgtcg cgggcctgtt cggcgacttc ctcaaggcgg cgggcgtgga
    17221 ggtcaccggg gtgcggggca gcggcatcat cacggccgcc gaggtgggca cgtggggccg
    17281 cgaggaggtg ctgcggctgc tgcgcgaggg cgacgacccg gcggcggacg cggtgctgct
    17341 gcccgacacc gcgctgcaca ccgccgcctg gctgccggaa cttgaggccg tggcgggcaa
    17401 gccggtcctc acggccaatc aggtgaccgc gtgggaaggg ctccggctgc tggggcacac
    17461 gcccgtctgc ccggccctgg gcggcctctt cgccgcgccg cggccggtcg ggaccgtcgg
    17521 ggccgagggg agctgaggag aaccggggcg ggcgcaggcg ggccgggacg gcccggcagc
    17581 gcccggcgcg tccgaacggc cccgcgccca ccgcacgccc cggcgcgccc gaacgcaccc
    17641 cggcgcgccc gccgcgcggg accggcccgc cggtcccgcg ccgcgtgcgc cgcgcacgcg
    17701 gcacggaacc gggccgccgg ccgcctcaga gcgcgccgcg gtgctgccgg ccgctggtgc
    17761 ggaacgcgtg gatgggcacg cccgcggccc cggcggtccg caccgcctcg tcccaggaca
    17821 gggtccgccc cccgaccgcg aacagcgggc cgctcgcccg gccggcgacc agccgggcca
    17881 gcagcgcttc cgcctgcccg ccgagttcgc cgccggcccg gggtcttatc cgggactcgt
    17941 ccgacacctc aagggcgagg aggtcgagca cgcgcacgtc gctctcccac agaagcgccc
    18001 acagggcgcg gtgcaccacc gggaccgact cgtcggccag cagccgcagg aagcggtcga
    18061 gggggatgga ttcagccatg atcgtcatgg tccgggagta ttccgtcagc gccgccgcgc
    18121 gtacagggcc gcagccgccc ggttcccccg ggaacggcgg aacggcccgc gcaccggcgg
    18181 ccgtcgggcg ggcgcgcggc cggtcgccgc gggcgttcag tcgcggccgg cgagcaggtc
    18241 ggcgaggtgg tcgggcgaca tggggcgggc gtagtgccag ccctgcccgg tgtcgcagcc
    18301 gatgcggcgc agccgctccg cctgggccgg gccctccacg cactcggcgg tcacggtgag
    18361 gccgagcttg tgcgcgagct ggacgagcga gctgacgatg gtctcgtcgg ccgggttgag
    18421 gtggcgcgcg gtgcggaagc cccgcacgaa catgccgtcc agcttcaggg cgcgcaccgg
    18481 gagccggctg aggtaggcca ggttggagta cccggtgccg aaatcgtcga tcgcgatccg
    18541 cacgcccatg tcggccaggg cctggagggc ctgcaacggg cgcccggccg agcccatgac
    18601 ggcggactcg gtgagttcga gctggagcag ccctgagggc aggcccgagt cgtcgagcgc
    18661 cttggccacg tcgctgacca ggtcggagtc ccacacctgc cggacggcga cgttgacgct
    18721 gacgaacagg ggcggtcccg ggtgctccac ctgccagcgg cgggcctgcc ggcacgcctc
    18781 gccgaggatc cagcggccca gcggcacgat cgcgccgttc tcctcggcga ggccgatgaa
    18841 ccggtcgggg ccgagcgttc cgaactgcgg gtgccgccag cgcaccagcg cctcggcgcc
    18901 gcgcacgatg tcgtcggcca gtccgacgat cggctggtac tccagcgtga actcgccgcg
    18961 gtccacaccg cgccgcagcg tcgaggacag cgactgccgc gtcatccggt gcgcgttgcg
    19021 ctcggggtcg aacagcgtcc agcgggcctt gccgtcggcc ttcgcccagt acagcgtcgt
    19081 gtcggccgcc tgcatcagcc cggtggccgt ggtcgtggcg gactcgcgct cgaccacgcc
    19141 gatgctggcc gagacggcga gccgctgccc cgccaggtcg aacgggcgtt gcagcgcggc
    19201 gagcatggtc tcggccagct cggtcagctg ctcggtgccg gtcgacccct ccacgagcac
    19261 ggcgaactcg tcgcccccga gccgtgccac gaggtgcccg cccgcgcccg tcgcacactc
    19321 ggcgagacgc tggccggcgg cgccgagcaa ctcgtcgccc acgcggtggc cgagggtgtc
    19381 gttgaccgcc ttgaagccgt cgatgcccac ctggcacagc ccgatccgcc cggtggcgga
    19441 gtcggagagc gcggccgtca gccgctcgaa gaacagggcc cggttcggca gccgggtgac
    19501 cgggtcgtgc atctggatgt gccgcagccg ctcctggagc gcgcgccgct cgctgatgtc
    19561 gagcacggtc agcagggccg cggagctctc cgtcggggtg ggcaggaccg tcacctcggc
    19621 ccacaggctg tgcccgtcgg cgtgcttgag ccgccgcgtg cagcgcatgt ggtcgctgtg
    19681 gccgcgcagc accgcgtggt aggagccccg ggtgcgcccg tcgaggccga gcccggcgac
    19741 ggcgtcggcg cgcacaccgg cgaggcgttc cggctcgact ccgaggagga gcccgaacgc
    19801 ggcgttggcg gcgaggatct ggcccgcggc gccgacgagc gccatgggga actgggcgat
    19861 ctggaacgcg gcccggtagt ccctgagcag gtcactttcc gtaagggacg gtgggttcgc
    19921 ctggtgggcg ctgccggggt cgtggcccgg tgtttcgtgg ggtccgttca ccgatcgctc
    19981 ccgatggtgc tgtcgggcgc tccccggctg cccgcttggc gtatccgcgc tggaaatgtg
    20041 gcgatcatag aggctgcggc gcgggtggag ccagtgcccg tcgcgtccgt ttcgtaaccc
    20101 gaaacctgtg cttccgacag actttcgagt agctgatcgt ttctgctcgt cgggtgtgct
    20161 ctcgggatcg ttcccgacag aagtgcacgc agggtaatcg tattgccatg acccggccgg
    20221 gctatcgaaa cagggcaaaa acggggaatc cggaacaggg tggtgagcgt gctcccgccg
    20281 tccgccccgt ccctcctccg ttcccccggt tcccgcccgc cggcctcgcc ctccccaccc
    20341 gtccgctccc gctcctccag cccctcccgt cccacccgca cctgacgttc tgcccgtttc
    20401 ccgctccccg tgtcccgccc gaggcccgat cggaggtcgc cgtgcgccgt gcccgccgcc
    20461 gccccgccgc cgtgctggcc gtactggccg ccctgctcgg cgccaccctc accgaggggc
    20521 ccggcatctc cgccctcgcc gacgagccgt gcagcctgcc gcgttccgcc gtccaccact
    20581 ccgagggcgt ggacagctgg aacgacgcct acccgcgccc cgtgggcacc gtgcgcggcg
    20641 tcatgctgtt cctctccttc accgacgccg cgccgcggct gagtccggag cggatcgcgg
    20701 aggactactt ccccgccacc accgactact tccgcgccgc ctcctacgga aagctcgacc
    20761 tgcggaccga ggtggtgccc gagtggctgc gcatgccggg cacgtcccag gagtacggga
    20821 tacggcgcga ctgggagccg gaccggcgct ccgcctatct caaggacgcc ttgaagaccg
    20881 tctcgggacg ggtggacctc gccgcctacg acatcgtcta cctggtcgcc gacccggacg
    20941 cgcccggcgt ggacccggac gcgaccaagg tggtgaactt cgacaagccg gtcaccgtcg
    21001 gcgacgccga gatccgccgc ctcgtcacgg tcttcgagca gcgccgcccc gatcgcaacg
    21061 tgctcgccca cgagaccggt cacgtcttcg acctgcccga tctctacgac cggccggagg
    21121 acggctgggg ggactgggac acgcacgtcg gggactggga cctcatgggc agccagttcg
    21181 gcctgtcgcc cgag
//
