LOCUS       NZ_CP084541            24058 bp    DNA     linear   CON 20-NOV-2024
DEFINITION  Streptomyces marincola strain SCSIO 64649 chromosome, complete
            genome.
ACCESSION   NZ_CP084541
VERSION     NZ_CP084541.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces marincola
  ORGANISM  Streptomyces marincola
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 6629020)
  AUTHORS   Shi,S.
  TITLE     Strepomyces indimicinicus sp. nov., an antibiotic producing
            actinomycetes isolated from the marine environment
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6629020)
  AUTHORS   Shi,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2021) Key Laboratory of Tropical Marine
            Bio-resources and Ecology, South China Sea Institute of Oceanology,
            Chinese Academy of Sciences, 164 Xingang West Road, guangzhou,
            Guangdong 510301, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. V6.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 444.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_020410765.1-RS_2024_11_18
            Annotation Date                   :: 11/18/2024 03:45:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,763
            CDSs (total)                      :: 5,689
            Genes (coding)                    :: 5,612
            CDSs (with protein)               :: 5,612
            Genes (RNA)                       :: 74
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 77
            CDSs (without protein)            :: 77
            Pseudo Genes (ambiguous residues) :: 0 of 77
            Pseudo Genes (frameshifted)       :: 21 of 77
            Pseudo Genes (incomplete)         :: 60 of 77
            Pseudo Genes (internal stop)      :: 2 of 77
            Pseudo Genes (multiple problems)  :: 6 of 77
            CRISPR Arrays                     :: 10
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:57:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3288427
            Orig. end                         :: 3312485
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP084541.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24058
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="20"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24058
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24058
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14058](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14058
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            30..308
                     /locus_tag="LC193_RS14095"
                     /old_locus_tag="LC193_14095"
     CDS             30..308
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018892260.1"
                     /locus_tag="LC193_RS14095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_14095"
                     /product="DUF2277 domain-containing protein"
                     /protein_id="WP_226074458.1"
                     /transl_table=11
                     /translation="MCRSIKTLRPPATPEVTDDDIRAAALQYVRKVSGFRSPAAHNREV
                     FDAAVAEVAEATRHLLGHLQVRGTTRTAPNGTAPNSERDTGSGPLPG"
     gene            329..3481
                     /locus_tag="LC193_RS14100"
                     /old_locus_tag="LC193_14100"
     CDS             329..3481
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003961052.1"
                     /locus_tag="LC193_RS14100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_14100"
                     /product="AAA family ATPase"
                     /protein_id="WP_226074460.1"
                     /transl_table=11
                     /translation="MFDTMIGRQHAAGVLRAEIARTTTSHGGLVLVTGEAGIGKTTLVT
                     GAAEEARARGALVLGGSCWHAENAPGHWPWTQVVRGLRRAATAEEWAAAEDAAGADLAG
                     WTTGGDGGGAESFALHDAVTTALVTVSQRRPVALVLEDLHWADTGSLRLLDFAARHTWF
                     ERLLLICTYRDTDVAAEDHPLHALLMPLVSRATTLALTGLAPHEVGALMARTTGAAPDA
                     ALAARVHRHTGGNPFFVEQTARLWHGGEGTGVPPGVREAVRRRLGLLPEQVVALLTRAA
                     VLGRAFHRRVLAATAPGTGTEVDRLLAHAEAARLVARDGPDRFAFAHDLVRETLHESLD
                     GGERRRRHAAVVRALADEPALSDLVPPADLARHARLAGDELDPAHAVELLRSAAEDAKG
                     RMAFDESLGHMRDAFRLAEALGPRRHVLVGLDLAAELRHTGDAAGAAAAFARCAEAARA
                     LDDAELLARVALSLHDSHGVTSRGGIDRPHADLLHDAHRRLVGTPAGRPLPTGDDPATL
                     ERVVRELSIRCAVLARRTGDDDALAFSLWSLHDAIWGPGTAAEREALITELAGLARRGG
                     NRDLQHFSTALGWVTLLERGDPAYLHQLDAFLKSAEHTGRPRYRLSAAVDRAIVAALHG
                     RFTEAEDLHAELVELTRHAGNAQHMGAFRDHMRRGLLLAQGRFPELAEANAAGAAKPQA
                     HPELVAGIAAAEQGDAAAALRQYETSLPVPRPRYAEALWLRFQAQTAALSGDADLIARA
                     RAELAPLTGQWAVGLFGFDIGGPWALWSALLDQAEERWDAAVAGFTEAATSADRLLARP
                     WAVRARLGLGRSLLGRGRPGDADTARALLREAEEEAARLGLRHIEEQAATALAAPHEPR
                     RTDEFRFDGSVWTLRYAGRTVHLPDAKGLRDLWRLIGQPGQDIAAGRLLDPAGEAPLYG
                     GDPVLDDEAKARYRRHLEQLDDEVDRAAARGDAARAAELDRERAALLTELRTAAGLGGR
                     TRRLGDEAERARKTVTARIRDTLRRLDTRHPELAAHLRASVSTGTMCAYRPPPDEAPRF
                     RL"
     gene            complement(3498..4172)
                     /locus_tag="LC193_RS14105"
                     /old_locus_tag="LC193_14105"
     CDS             complement(3498..4172)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LC193_RS14105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LC193_14105"
                     /product="hypothetical protein"
                     /protein_id="WP_226074461.1"
                     /transl_table=11
                     /translation="MDCYVCSLCPKVRAALDLGPHQLPVPHAAAWSAERTAVAGALTVR
                     ADGAGLAYRDERPGDRDGQGVLWARIGQAQGQGRPNFRALHSGRQRGAMLDKLCQVCGG
                     QASRTGRGWLFLLQRPAPPPEGRDWPEGLLCTKPPVCRPCAALAMRHCPHLTDPVVVRS
                     RKPRTWGVFGGFFTPAPDGGLTPHADSALPYGDARAPWFLASQLVVELTRCTVESAPRP
                     VR"
     misc_feature    4168..4183
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.37"
                     /tool="antismash"
     gene            complement(4180..4461)
                     /locus_tag="LC193_RS14110"
                     /old_locus_tag="LC193_14110"
     CDS             complement(4180..4461)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LC193_RS14110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LC193_14110"
                     /product="hypothetical protein"
                     /protein_id="WP_086159728.1"
                     /transl_table=11
                     /translation="MTTICRTFPPTPPPAWLVPGIRVRDAASRGLGVVLLLQDARREVS
                     TRWISRPVRALLRADCWGGPLWWAPAAGLSPADECVRCLGHCPLPALA"
     misc_feature    complement(4477..4492)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.75"
                     /tool="antismash"
     misc_feature    4648..4661
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 17.97"
                     /tool="antismash"
     gene            4690..5565
                     /locus_tag="LC193_RS14115"
                     /old_locus_tag="LC193_14115"
     CDS             4690..5565
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138945.1"
                     /locus_tag="LC193_RS14115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_14115"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_226074462.1"
                     /transl_table=11
                     /translation="MPNVRAIPTLRRRRLGGTLRRYRHEAGVTLVTAATAMGWDDSKLS
                     RIETAVARLLPQDVAKLLSQYGVTDPQVIAALEGLAKDAGKQGWWQAYGDVVALNYKDY
                     LTLETDAESVHIYTPGLVPGLLQTGPYAREIIAGISTTHTSEEVAALAEIRKMRQAILT
                     TRPEGRPLKLWAVVHEAGLHQRFAGQPFLMRQQLKHLLDMTELPNVTIQVMPLIATPNP
                     GMLGLFEIVRFPHPWATVVNLENIQGGYFVEGTEDVKVFESAFERVVAAALSVDDSRQL
                     IRTLIERNRQ"
     gene            5562..5783
                     /locus_tag="LC193_RS14120"
                     /old_locus_tag="LC193_14120"
     CDS             5562..5783
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138944.1"
                     /locus_tag="LC193_RS14120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_14120"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_226074463.1"
                     /transl_table=11
                     /translation="MNARTDDLHTVDLTNATWRKSSRSNGAAQCVEATDLPGGGIAIRD
                     SKNPHRTPLRWAAAQWNAFRQGIVDGTL"
     gene            complement(5852..6730)
                     /locus_tag="LC193_RS14125"
                     /old_locus_tag="LC193_14125"
     CDS             complement(5852..6730)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677110.1"
                     /locus_tag="LC193_RS14125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_14125"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_226074464.1"
                     /transl_table=11
                     /translation="MAEPHPADSVAEAFEAQRDRLRAIAHRVLGSHADAEDVIQETWLR
                     LSRQDPATIRNLPGWLTTVVGRISLDVLRSRRAHPEASLDARLPDLVVTVDDGPGPEDD
                     VALADTVGLALLVVVQSLGPSERMAFVLHDLFAVPFHDIAQILGKSTDATKMLASRARR
                     KVRATEQPTSSGRERREVVDAFLAAAREGDFDGLLRVLDPDVRLTAETPGGTVVSLGAT
                     EVATGARLAAGAAARGRAVLVNGLPGWLAWHADGSPLSVLAFSVTDGRITAIVAVSDPA
                     RLAAMDLPEPR"
     misc_feature    6715..6729
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.25"
                     /tool="antismash"
     gene            6825..7274
                     /locus_tag="LC193_RS14130"
                     /old_locus_tag="LC193_14130"
     CDS             6825..7274
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1298: putative carboxymuconolactone decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014180292.1"
                     /locus_tag="LC193_RS14130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_14130"
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="WP_226074465.1"
                     /transl_table=11
                     /translation="MAVRMETPVGPDVMTAVQHLIKAVHAGGVDPLVLELVHLRASQIN
                     GCSACVHTGVASAKRRGETEERLHQVAAWRETPFFSEPERAALALAEAVTRIQDGAPGV
                     TDAVWEAATAHFDEKQLASLTLHIAMTNFFNRVNHTIREQAGKTW"
     gene            7438..7731
                     /locus_tag="LC193_RS14135"
                     /old_locus_tag="LC193_14135"
     CDS             7438..7731
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LC193_RS14135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LC193_14135"
                     /product="hypothetical protein"
                     /protein_id="WP_226074466.1"
                     /transl_table=11
                     /translation="MGETTGDPVGPVWRTWLDGEEIELPASINGIRAALPPERREQFDE
                     AVGAAAAGDLELLLGHWAQETRPDLRAAQEAVFRRLEAGDSTGFVAAEDLDA"
     gene            8409..9632
                     /gene="fxlM"
                     /locus_tag="LC193_RS14140"
                     /old_locus_tag="LC193_14140"
     CDS             8409..9632
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04364.1"
                     /locus_tag="LC193_RS14140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_14140"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_226074468.1"
                     /sec_met_domain="PCMT (E-value: 4.4e-34, bitscore: 116.4,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNEHRMTAEASAGAGELRERMVHELVRSGAIVHPAVEAAFRAVPR
                     HRFAPHVPAAEVYGAPEAIFTKRTDDGRVVSSVSAPWLHARMLEAARLAPGMRVLEIGS
                     GGCNAALLAELVGPAGVVTSLDIDPDITGRARRLLDDAGYQRVQVRTGDGALPVPDTPA
                     GGWDRIIVTAGSADLPETWLDQLSGSGRLVVPLRFRGLSRTFAFAWRGDQLRSDTTIVS
                     GFLAMRGKSADAPRIVRLADEDVRLTVDERQPCDEAALRAAFSSVGHEVWTGVRLTGSE
                     GVLPHLDVWLAGVVAPYGRLRASRAAAERGLVGWVLGTGAAAIWTDSSLAYLALRSAPE
                     HADQFELGVVAHGPDREDLGLALADEVIRWNTTARHQGEPEVRVHRLDDLAPPGVVIEK
                     PSIRLTIS"
     misc_feature    9698..9715
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.29"
                     /tool="antismash"
     gene            9721..9906
                     /locus_tag="LC193_RS14145"
                     /old_locus_tag="LC193_14145"
     CDS             9721..9906
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018840603.1"
                     /locus_tag="LC193_RS14145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_14145"
                     /product="hypothetical protein"
                     /protein_id="WP_086159721.1"
                     /transl_table=11
                     /translation="MTPSSAPSPAPAPELADAFDLDLRQQPVSGLHVWLSGGEEEGDTT
                     GDGCGESPPQGPTTGC"
     gene            10001..12856
                     /locus_tag="LC193_RS14150"
                     /old_locus_tag="LC193_14150"
     CDS             10001..12856
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.5"
                     /locus_tag="LC193_RS14150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_14150"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_226074470.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.8e-121,
                     bitscore: 404.1, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.4e-07,
                     bitscore: 30.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1e-27, bitscore:
                     95.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRRLFAAHPVAMARVPLRPDQGVGDEADGLLIEGVLLAGSIDLS
                     KARRDARTRATLRAYDLRSRSRTTPHGVFAAVAPAALTARATTLRLGRAHRAITMPSAR
                     WLTALADQLLDEHPELLPTLTLTTSNLVASRGDRFVAERPTERGAETGSVRNTEVSRWL
                     LRACADGAPAADLLADLSKRHPDVAPATIARAVLNMVKAGALLDDLLPDDLRADPLQHL
                     LGRLPAQSPSAHTLRRLAAVLREADAHTPGSPRRRPLLSAARDLANSLRPTPRPLTADT
                     LADAQISLPWSVGDSAALAASVLWRIGHRTPPLGDYHRRFLARYGRHRLVPLLEALDPV
                     AGLGPPTAHDALGTDEGLSPSRMTALASLLAGALSTGTPEIALQDHHLAQLANPSPLPP
                     PRTAEIHIQLLNSESEAPDIAVVPGTGSQDAGAAPGRWTRWLPELAPDEHAGNGTGPMV
                     AEIACRTRTAATGTLNAETGTAPWRIPLGVPRRPEDLIPEELALVVSGTHLALWSTRHD
                     RPVTPVLRSRVAPRLLPPAARALHLLGHANTRPWHPWSWGPLSAFPFTPRVRYHGILLC
                     PARWQVPAELATAAGNRAAFTSTLEVWQRTVHPALPGTVVVAENDRRLPLDLHDPDDRE
                     LLRRSVHRGTRSLHEPLGSPEALRVLPGPDRERHHLELVVALTRRDSPPSSRPSPRRAI
                     RGAHAGRHLPGGSWLSAALPGPSDLHDTTLTELSPLLERLTTAPDIDRWFWLRYTTPAL
                     GPHLRLRVHGDPTALNSRVQPQLATATARLRRQGLCSGLHLEPYEQEIERYGGEQAMAS
                     AECFFHADSALALRALRLTDSQRLLLAAASSAEIAGALAPEQPRRALAPGRLTRDQRRH
                     RDTLRAITRRGAAALIPPFLATVHAQRRKALLAYRDVLAPAFAAPCASDLIHMHNNRLL
                     STDPSHERLARTLAADLLHRS"
     aSDomain        10379..10633
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_LC193_RS14150_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="6.90E-10"
                     /identifier="RREFam001.1"
                     /label="LC193_RS14150"
                     /locus_tag="LC193_RS14150"
                     /protein_end="211"
                     /protein_start="126"
                     /score="30.5"
                     /tool="antismash"
                     /translation="TTSNLVASRGDRFVAERPTERGAETGSVRNTEVSRWLLRACADGA
                     PAADLLADLSKRHPDVAPATIARAVLNMVKAGALLDDLLP"
     gene            12853..14058
                     /locus_tag="LC193_RS14155"
                     /old_locus_tag="LC193_14155"
     CDS             12853..14058
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.5"
                     /locus_tag="LC193_RS14155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_14155"
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="WP_226074472.1"
                     /sec_met_domain="LANC_like (E-value: 9.9e-29, bitscore:
                     98.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDEHRALSATKSQELALALGPTRAVAAAVSARAAHTLCYGLAGT
                     ALLHACLGDATTAVRHWNAASQVLGDAPADGIHTGPGALAASLIIGTAHLPERGPHHAL
                     APRATSWLSARAQALAQLQRTSPGSWAPWAVYDAIKGLSGIGRILLVSHATGHRAEATP
                     GLHAALTTLIRMILTDQGTRPGWWLPAHAHPPSVPVPPSGAATTGMAHGIAGPLAFLAL
                     AHLAGHIAPGQHDAIAGAAHWLLTWADPGPSWPPHVSGADLDAGPTPPPGVIPGRRTAW
                     CYGTPGIATALTHAGHALGEPAFLRTATAALDHLATDISTWDTEGPGLCHGAAGVLAGA
                     RHGGSRLAARARDTVLSLLSPPSAAPGLLGGRAGTALALAADAGLFARQRAAPWESVLL
                     IS"
     gene            complement(14173..14964)
                     /locus_tag="LC193_RS14160"
                     /old_locus_tag="LC193_14160"
     CDS             complement(14173..14964)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014142082.1"
                     /locus_tag="LC193_RS14160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_14160"
                     /product="oxidoreductase"
                     /protein_id="WP_226074474.1"
                     /transl_table=11
                     /translation="MDLHLAGKAAVVTGASRGIGLAVVAALVNEGMRVVAGARTTTPEL
                     VATGAICVPVDLSTAEGPARLIERAEAELGGLDLLVNNVGGGDSGEGQTGGLLTFTDEQ
                     WQQAYDLNFLSAVRATRAALPRLVEDGGGAVVNVSSDAARSPHSSPMPYTTAKAALTAF
                     GKAIAEEFGPQGVRVNTVSPGAVRTSLWDGPGRYGVALAEKMGMEHAQLLDQIPAATGM
                     LTGRFIRPDEVADLVAYLASPAAASIVGVDYVIDGGATKTT"
     gene            15095..15700
                     /locus_tag="LC193_RS14165"
                     /old_locus_tag="LC193_14165"
     CDS             15095..15700
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009075249.1"
                     /locus_tag="LC193_RS14165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_14165"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_226074476.1"
                     /transl_table=11
                     /translation="MDQRSGRPLRADAERTVRAILEAAERVLSADPAATMEQIAEAAGV
                     ARTTVHRRFTSREALVEALAAWATRQFHEAVTSARTDSVPPLVALYQVTANVLRVKTSW
                     GFAMSRGTPEDPEVARVHADVLAQCDRLFLRAAEAGVLRREVDLEWARRVYYALIHEAA
                     HDRGEAADDEGGDVEALATRVVDTLLRGVGGRGAELGA"
     gene            complement(15771..16655)
                     /locus_tag="LC193_RS14170"
                     /old_locus_tag="LC193_14170"
     CDS             complement(15771..16655)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018957211.1"
                     /locus_tag="LC193_RS14170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_14170"
                     /product="ABC transporter permease"
                     /protein_id="WP_226074478.1"
                     /transl_table=11
                     /translation="MTTATSADAAPKQSGKDGDEAEDTYTPTAETLGAVLAGVERPQRP
                     SPLSASLTFGWRAMLKIKHVPEQLFDVTVFPIMMTLMFTYLFGGALAGSTSEYLQFLLP
                     GIMVMSVVMTTMYTGVAVNTDIQKGVFDRFRTLPVWRPAAMVGYLFGDMLRYAMASVVI
                     LIVGLILGYRPEGGVLGVAGAILLLIVFSFAFSWIWTMFGLMLRSEKSVMGISMLVLMP
                     MTFLSNILVDPGTMPGWLQAFVDVSPVAHLVEAARGLMDGNVDTGEITWVLVASAVLIA
                     VFGTLTMRLYNRK"
     gene            complement(16652..17683)
                     /locus_tag="LC193_RS14175"
                     /old_locus_tag="LC193_14175"
     CDS             complement(16652..17683)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019525923.1"
                     /locus_tag="LC193_RS14175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_14175"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_226074480.1"
                     /transl_table=11
                     /translation="MGNGTGEPAIETRGLVKIFGDNRAVDGVDLTVPAGTVYGVLGPNG
                     AGKTTTVRMLATLLRPDAGEARIFGLDVFTQADAVRSRVSLTGQYASVDEDLTGTENLV
                     LLARLLGHRKPAARERAAALLDAFGLTEAADRQAKNYSGGMRRRLDIAASILNTPDLLF
                     LDEPTTGLDPRSRNQVWDIVRAVVAQGTTVLLTTQYLEEADRLAGRIAVIDKGRVIAEG
                     TPGQLKSSVGSGSIHLRLRDADRRPEARELLERVLGTTVSADADPLALTARLMQDGNAS
                     GPAELASHALAQLAAGGIVVDDFSLGQPSLDEVFLALTDGKADRSATDTTATTRETKQE
                     AVA"
     misc_feature    17700..17715
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.59"
                     /tool="antismash"
     misc_feature    17709..17724
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.59"
                     /tool="antismash"
     misc_feature    17718..17733
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.59"
                     /tool="antismash"
     misc_feature    complement(17791..17804)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.86"
                     /tool="antismash"
     gene            complement(18091..18864)
                     /locus_tag="LC193_RS14180"
                     /old_locus_tag="LC193_14180"
     CDS             complement(18091..18864)
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018559323.1"
                     /locus_tag="LC193_RS14180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_14180"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_226078597.1"
                     /transl_table=11
                     /translation="MKNAALLVNRASLSHKIRYAARNPARIAPHARRVARDTWLRLRHR
                     DHVSYYRAVMASDTARDPDKAVGSASRARWRALGEMQFTYLTAHGLRPEHRMLDIGCGN
                     LRAGRWFIDYLGPGAYYGIDISPDILVSAKHTLVAYGLQDKVPHLTPTRDLTLDFLPDA
                     YFDVVHAHSVFSHSPLSVIDECLAHVGRVMAPGAFFDFTFDRTEGREHHVLREDFYYRT
                     ETLVALAERHGLRARFEEDWEKLPHGQSRIRVTAS"
     misc_feature    18933..18948
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: strong, score: 30.57"
                     /tool="antismash"
     misc_feature    18933..18949
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 25.37"
                     /tool="antismash"
     misc_feature    complement(18934..18949)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 23.11"
                     /tool="antismash"
     misc_feature    18959..18974
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: strong, score: 28.92"
                     /tool="antismash"
     misc_feature    18959..18975
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: strong, score: 30.13"
                     /tool="antismash"
     misc_feature    complement(18960..18975)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 24.53"
                     /tool="antismash"
     misc_feature    complement(18992..19008)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 23.5"
                     /tool="antismash"
     misc_feature    complement(18993..19008)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: medium, score: 25.7"
                     /tool="antismash"
     gene            19033..21291
                     /locus_tag="LC193_RS14185"
                     /old_locus_tag="LC193_14185"
     CDS             19033..21291
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1037: heavy metal
                     translocating P-type ATPase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017944524.1"
                     /locus_tag="LC193_RS14185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_14185"
                     /product="cation-translocating P-type ATPase"
                     /protein_id="WP_226074482.1"
                     /transl_table=11
                     /translation="MTATASDSAEVELAIGGMTCASCAARIEKKLNRMDGVTASVNYAT
                     EKAKVSYADGVTVADLVATVEATGYTAEEPRPAAAPAPEGGAEPPDDLAALRHRTAVTW
                     ALAVPVIVLAMVPAWQFEYWQWLSLTLAAPAVVWGGWQFHRAAWTNARHGAATMDTLVS
                     LGTLAALAWSVWALFFGHAGMPGMTHPFELTIERTDGAGAIYLEAAAGVTAFLLAGRYL
                     EARAKRRAGAALRALLDLGAKEVTVLRGGAERRVPVADLRPGDRFVVRPGEKIATDGVV
                     VEGSSAVDASMLTGESVPVEVAEGAQVTGATINAGGRLVVEATRVGADTRLARMAKLVE
                     DAQNGKAAAQRLADRISAVFVPAVIAIAVATLGVWLAAGGGPTAAFTAAVAVLIIACPC
                     ALGLATPTALLVGTGRGAQLGILIKGPEVLENTRRADVVLLDKTGTVTTGRMALTGVTA
                     AAGEDEAEALRLAGALEHASEHPIARAVAAGAAEAAGTTAEQLPPVREFTNVPGLGVRG
                     LVEGRAVLAGRAGLLTGAGVTLPAELAEAAAGAEAAGRTAVLVAWDGRARAVLAVADAV
                     KDSSAEAVRRLRALGLTPVLLTGDNETVARAVAAEVGIDEVIAGVLPEEKVAVVRRLRD
                     EGRTVAMVGDGVNDAAALAAADLGLAMGTGTDAAIEAGDLTLVRGDLRAAADAIRLSRR
                     TLRTIKGNLWWAFGYNVAALPLAAAGLLNPMLAGAAMAFSSVSVVANSLRLRTFRAAS"
     gene            21486..22013
                     /locus_tag="LC193_RS14190"
                     /old_locus_tag="LC193_14190"
     CDS             21486..22013
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010032404.1"
                     /locus_tag="LC193_RS14190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_14190"
                     /product="tellurite resistance TerB family protein"
                     /protein_id="WP_226074484.1"
                     /transl_table=11
                     /translation="MAIWDRIKDSAKGRTGSGGSGGSGSGGSGGGQQLVSMFKNQLSSM
                     KTELKSGAYRDASMAMCALVAAADGSVDHNERQHVESLIVSNDVLQNFPADSLRQRFNK
                     HVDQLVGNFQAGRAAALQEIAKVQKKPMEARAVVQTGIVIAGADGYFAQAEQQVIREVC
                     GALGLSPSEFNM"
     gene            22188..22628
                     /locus_tag="LC193_RS14195"
                     /old_locus_tag="LC193_14195"
     CDS             22188..22628
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020129231.1"
                     /locus_tag="LC193_RS14195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_14195"
                     /product="SgcJ/EcaC family oxidoreductase"
                     /protein_id="WP_226074486.1"
                     /transl_table=11
                     /translation="MRTSPEPQTAAGGHRPPTEAEIRALFARWNDALATGDAEVVADRY
                     AADAVLEPTQSNRIRTDRAGIVDYFEHFLTQRPTGEIDESYVEILGRDAAVDGGAYTFH
                     LTDPATGEPRDVRARYTFVYERDRRTGTWLIVNHHSSVMPEG"
     misc_feature    23214..23223
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.29"
                     /tool="antismash"
     misc_feature    complement(23907..23921)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
ORIGIN
        1 ggcgttcggg acgggtgcac actggtggca tgtgccgaag catcaagacg ttgcgcccgc
       61 cggccacgcc cgaggtcacc gacgacgaca tccgcgccgc ggccctccag tacgtgcgca
      121 aggtgtccgg attcaggtcg cccgcggcgc acaaccgcga ggtgttcgac gccgcggtgg
      181 ccgaggtggc ggaggcgacg cggcacctgc tcggccacct ccaggtgcgc ggcaccaccc
      241 gcaccgcgcc gaacggcacg gcgcccaaca gcgaacggga caccggttcc ggcccgctgc
      301 ccggctgacg cgagcacgac gggaccacgt gttcgacacc atgatcgggc ggcagcacgc
      361 cgccggagtg ctgcgcgccg agatcgcccg caccacgacc agccacggcg gcctcgtcct
      421 ggtcacgggc gaggcgggca tcggcaagac cacgctggtc acgggcgccg ccgaggaggc
      481 gagggcgcgc ggtgccctcg tgctcggcgg ctcctgctgg cacgcggaga acgccccggg
      541 ccactggccg tggacccagg tggtccgcgg gctgcggcgg gccgcgacgg ccgaggagtg
      601 ggcggcggcg gaagacgcgg cgggcgccga cctggcgggc tggacgaccg gcggggacgg
      661 cggcggggcc gagagcttcg ccctgcacga cgcggtgacg acggcgctgg tcaccgtgtc
      721 gcagcggcgg cccgtcgcgc tcgtgctcga agacctgcac tgggcggaca ccggatcgct
      781 gcggctgctc gacttcgccg cccggcacac gtggttcgaa cgcctcctgc tgatctgcac
      841 ctaccgcgac acggacgtcg ccgccgagga ccacccgctg cacgcgctgc tgatgcccct
      901 ggtgtccagg gccaccaccc tcgcgctcac cggcctcgcc ccgcacgagg tcggcgcgct
      961 catggcccgc accacgggcg ccgccccgga cgcggccctg gccgcccggg tgcaccggca
     1021 caccggcggc aacccgttct tcgtcgagca gaccgcacgc ctgtggcacg gcggcgaggg
     1081 caccggcgtg ccgcccggcg tgcgcgaggc ggtgcggcgg cggctcgggc tgctgcccga
     1141 gcaggtcgtg gcgctgctga cccgggccgc cgtgctcggc cgcgcgttcc accgccgggt
     1201 gctcgcggcc accgcgccgg ggaccggcac ggaggtggac cggctgctcg cgcacgcgga
     1261 ggcggcccgg ctcgtcgcgc gggacggccc cgaccggttc gcgttcgccc acgacctggt
     1321 gcgcgaaacg ctgcacgagt cgctggacgg cggggagcgg cggcgccggc acgccgccgt
     1381 cgtccgcgcg ctggccgacg agcccgcgct ctccgacctc gtgccgcccg ccgacctggc
     1441 gcggcacgcg cgcctcgcgg gcgacgagtt ggaccccgcg cacgcggtgg aactcctgcg
     1501 gtccgccgcc gaggacgcca aggggcggat ggcgttcgac gaatcgctcg ggcacatgcg
     1561 cgacgccttc cgcctggccg aggcactcgg cccgcgccgc cacgtcctgg tcggcctcga
     1621 cctcgccgcc gaactgcgcc acaccgggga cgcggcgggg gcagccgccg ccttcgcgcg
     1681 ctgcgccgag gcggcccgcg cgctcgacga cgcggaactg ctggcccgcg tcgcgctgtc
     1741 cctgcacgac tcgcacggcg tgacgtcgcg cggcggcatc gaccgaccgc acgccgacct
     1801 cctgcacgac gcgcaccggc ggctcgtcgg cacccccgcc ggcaggccgc tgccgaccgg
     1861 cgacgacccg gcgacgctgg aacgcgtcgt gcgcgagctg agcatccgct gcgccgtgct
     1921 ggcgcggcgc accggtgacg acgacgcgct cgcgttcagc ctgtggtccc tgcacgacgc
     1981 catctggggc ccgggcacag cggccgaacg cgaggctctg atcaccgagt tggccggtct
     2041 ggcccgccgc gggggcaacc gggacctgca acacttctcg acggcgctcg gctgggtgac
     2101 gctcctcgaa cgcggcgatc ccgcctatct gcaccaactg gacgcgttcc tgaagtcggc
     2161 ggaacacacc ggccgaccgc gctaccggct gtcggccgcc gtggaccgcg ccatcgtcgc
     2221 cgcgctccac ggacgcttca ccgaggccga ggacctgcac gcggaactcg tcgagctgac
     2281 ccgccacgcc gggaacgccc agcacatggg ggcgttccgc gaccacatgc gccgcggcct
     2341 cctgctggcg caaggccgct tccccgaact ggccgaggcg aacgcggccg gggccgccaa
     2401 gccccaggcg caccccgagc tggtcgcggg catcgccgcc gcagaacagg gcgacgcggc
     2461 agcggcgttg cggcagtacg aaacgtccct gccggtgccg aggccccggt acgccgaggc
     2521 gctgtggctg cgcttccagg cgcagaccgc ggccctgtcg ggcgacgcgg acctgatcgc
     2581 gcgggcccgc gcggagctgg cgccgctgac cgggcagtgg gcggtgggcc tgttcggctt
     2641 cgacatcggc ggcccctggg ccctgtggtc ggcgctgctc gaccaggccg aggaacggtg
     2701 ggacgcggcg gtggccgggt tcaccgaggc ggccacgtcg gccgaccggc tgctggcccg
     2761 gccgtgggcg gtcagggcgc gcctgggcct gggccgttcg ctgctcggcc gggggcggcc
     2821 gggcgacgcg gacacggcgc gggcgctgct gcgcgaggcg gaggaggagg ccgcgcgcct
     2881 gggcctgcgg cacatcgagg agcaggcggc gaccgccctg gccgcaccgc acgagccgcg
     2941 ccgcaccgac gagttccgct tcgacggctc ggtgtggacc ctgcggtacg cggggcgcac
     3001 cgttcacctg ccggacgcca aggggctgcg cgacctgtgg cggctcatcg ggcagccggg
     3061 ccaggacatc gccgccgggc ggctgctcga cccggcgggc gaggcgccgc tgtacggcgg
     3121 cgaccccgtg ctcgacgacg aggcgaaggc acgctaccgg cgccacctcg aacaactgga
     3181 cgacgaagtc gaccgcgcgg cggcgcgcgg cgacgcggca cgcgccgcgg aactcgaccg
     3241 cgaacgcgcc gcgctgctca ccgagttgcg cacggccgcc ggcctcggcg ggcgcaccag
     3301 gcgcctgggt gacgaggcgg aacgcgcccg caaaacggtc accgcgcgca tccgcgacac
     3361 gctgcgccgc ctcgacaccc gccaccccga actcgccgcc cacctgcgcg cgtccgtctc
     3421 caccggcacg atgtgcgcct accgcccccc accggacgag gccccccgct tccgcctgtg
     3481 accgcgcggg cgcccgttca ccgcacgggc cggggcgcgg actcgaccgt gcagcgggtg
     3541 agttcgacga cgagctggga ggcgaggaac cacggcgccc gcgcgtcgcc gtagggcagg
     3601 gccgagtcgg cgtgcggggt gaggccgccg tccggcgcgg gcgtgaagaa gccgccgaac
     3661 accccccacg tcctcggctt gcgcgaccgc acgaccaccg ggtcggtcag gtgcgggcag
     3721 tggcgcatgg ccagcgcggc gcacgggcgg cagaccgggg gcttcgtgca gagcagcccc
     3781 tcgggccagt cccggccctc cggcggcggg gccgggcgtt gcagaaggaa cagccagccc
     3841 cggccggtcc tgctcgcctg cccgccgcac acctggcaca gcttgtccag catggcgccg
     3901 cgctgccgac ccgagtgcag cgcgcggaag ttgggccgtc cctggccctg cgcctggccg
     3961 atccgggccc acagcacgcc ctgcccgtcc cggtcgcccg gcctctcgtc ccggtaggcc
     4021 agcccggccc cgtcggccct gacggtcaac gcgcccgcga cggcggtccg ttccgcgctc
     4081 cacgcggcgg catggggaac gggcagctgg tgcggcccca ggtcaagggc ggcgcggacc
     4141 tttgggcaca gcgaacagac atagcaatcc acgtccttct cacgcgaggg cgggcaacgg
     4201 gcagtgaccg aggcagcgga cgcactcgtc ggccggggac agtccggcgg ccggggccca
     4261 ccacagcggg ccgccccagc agtcggcgcg gagcaacgcc cgcacgggac ggcttatcca
     4321 ccgggtgctg acctcgcgcc gcgcgtcctg gagcagcaga acgacgccca gcccccggga
     4381 ggcggcgtcg cggacgcgga tccccggcac gagccaggcg ggcggcgggg tgggcgggaa
     4441 cgtgcggcag atcgtggtca tggtgacccc tcgtcgccgg aaaggcgttc gactccgggt
     4501 aatcgcgcgg gaacggcctg cgatcacgcg ttgggaaagg aagaatgcgg caccaggaag
     4561 tcaacaggca agcttggcag cgcctttgac aggggaaagg gcacctcgca ccgcgtctgc
     4621 cgcacccgcg cggtacctcc gcgcacccaa accttctttt ccagcaccgg aggggtgtga
     4681 aatagcacca tgccgaatgt tcgggccatc ccaacattgc gcaggcgtcg gctcggcggg
     4741 accctgcgga ggtaccggca cgaggccggg gtcaccttgg tgacggcggc caccgccatg
     4801 ggctgggacg acagcaagct gtcccgcatc gagacggccg tcgcccgcct gctgccgcag
     4861 gacgtcgcca agctcctgtc ccagtacggc gtcaccgacc cccaggtgat cgcggcactg
     4921 gagggcctgg ccaaggacgc gggcaaacag ggctggtggc aggcgtacgg ggatgtcgtc
     4981 gccctgaact acaaggatta cctgacgctg gagacggacg cggagagcgt ccacatctac
     5041 acaccgggcc tggtgccagg gctgctccag accggcccgt acgcacgcga aatcatcgcc
     5101 gggatctcga ccacgcatac ctctgaggag gtcgccgccc tcgctgagat ccggaagatg
     5161 cgccaggcca ttctcacgac caggccggag gggcgcccat tgaagctgtg ggcagtggtc
     5221 cacgaggccg ggctgcacca gcggttcgcc ggccagccgt tcctcatgcg ccagcagctg
     5281 aagcacctgc tggacatgac cgagctgccg aacgtcacca tccaggtcat gccgctgatc
     5341 gctaccccga atcccggcat gctcggtctc ttcgagatcg tacgctttcc acatccatgg
     5401 gccaccgtgg tcaacctgga gaatattcag ggcggttact tcgtggaggg aacggaagac
     5461 gtgaaggttt tcgagtccgc cttcgaacgt gtcgtcgccg ctgccctgtc cgtggacgac
     5521 tcgcggcagc tcatcaggac ccttatcgaa aggaaccggc agtgaacgcc cgcacggacg
     5581 acctccacac cgtcgacctc accaacgcca cttggcgcaa atcgtcccgc agcaacggcg
     5641 cggcgcagtg cgtggaggcc accgacctcc ctggcggcgg catcgccatc cgcgactcca
     5701 aaaaccccca ccgcacccca ctccgctggg ccgccgcaca gtggaacgcc ttccgccaag
     5761 gcatcgtcga cggcaccctg taaccccccg gaccacggcc cgttcccccc acacgccccg
     5821 gcgggaacgg gccgacggcc cggtgggtgg ctcatcgcgg ttccggcagg tccatggccg
     5881 cgagccgggc ggggtcgctg acggcgacga tggcggtgat ccggccgtcg gtgacgctga
     5941 acgcgaggac cgagagcggg ctgccgtccg cgtgccaggc cagccacccc ggaaggccgt
     6001 tcaccagcac ggcccgcccc cgtgccgccg cgcctgcggc cagccgcgca ccggtggcga
     6061 cctcggtggc gccgaggctg acgaccgtcc cgcccggcgt ctccgcggtc agccgcacgt
     6121 cggggtcgag cacgcgcagc aggccgtcga agtcgccctc cctggctgcc gccaggaagg
     6181 cgtcgacgac ctcgcgccgc tcccgccccg aggacgtcgg ctgctcggtc gcccgcacct
     6241 tcctgcgcgc gcggctcgcc agcatcttcg tggcatcggt cgacttgccg aggatctgcg
     6301 cgatgtcgtg gaacggcacc gcgaacaggt cgtgcagcac gaacgccatg cgttcgctcg
     6361 gcccgaggga ctggacgacg acgaggagcg cgagcccgac cgtgtccgcg agcgccacgt
     6421 cgtcctctgg ccccggtccg tcgtcgacgg tcaccacgag atcgggcagc cgggcgtcga
     6481 gggacgcctc ggggtgggcc cgccgcgacc tgaggacgtc gaggctgatc cggccgacca
     6541 ccgtggtcag ccagccgggc aggttgcgga tggtcgccgg gtcctggcgg gacagccgca
     6601 accaggtctc ctggatcacg tcctcggcgt ccgcgtgcga cccgagcacg cggtgggcga
     6661 tcgcgcgcag ccggtcgcgt tgggcctcga acgcctcggc cacagagtcg gcggggtggg
     6721 gttcggccat ggtgtcacct ttcttcggcg cgttccgtca tgggtgatga cgggccggga
     6781 gcgtcccggg taaccgacga acgaacgccg aaggagcagg accgatggca gtgcgcatgg
     6841 agactccggt gggtcccgac gtgatgacgg ctgtgcagca tctcatcaag gcggtgcacg
     6901 ccggtggtgt ggacccgctc gtgctcgaac tggtccatct gcgggccagc cagatcaacg
     6961 ggtgcagcgc gtgcgtccac accggggttg cgtcggcgaa gcggcgcggg gagacggagg
     7021 aacggctgca ccaggtggcc gcgtggcgcg agacgccgtt cttctccgag ccggagcgcg
     7081 cggcgctcgc gctcgcggag gcggtcacgc gcatccagga cggcgcgccg ggggtgaccg
     7141 acgcggtctg ggaggcggcg accgcccact tcgacgagaa gcaactcgcc tcccttactc
     7201 tgcacatcgc gatgaccaac ttcttcaacc gggtcaacca caccatccgg gagcaggccg
     7261 ggaagacctg gtagccgtac ggctcaaggg gcggccgagg caccaccggc ggtcccaccg
     7321 gcccacggcc cgttcccccg cagaccccgg cgggaggaac gggccgacgg cgtgcgcctg
     7381 gtcatgctgc gggcccgccg cgcttaccgt ggcggcgagc acttcgggag gcacggaatg
     7441 ggcgagacga ccggcgatcc tgtcgggccg gtgtggcgaa cgtggctgga cggtgaggag
     7501 atcgaactgc ccgccagcat caacggcatc agggccgctc tgccgcccga gcggcgcgag
     7561 cagttcgacg aggcggtcgg cgcggctgcg gccggggatc tggagctgct gctcggccac
     7621 tgggcgcagg agacccgccc ggacctccgg gccgcccagg aagcggtgtt ccgacggctg
     7681 gaggccgggg actccacagg tttcgtcgct gccgaggact tggacgcgtg agccgccggt
     7741 accgcctcca gtacagcaac gaggcgcgcg acgccctgcg gaagatgagc agcccgcgcc
     7801 gtcggcggtt cgaggccgcc gtggccgaga tcgctgtcga ttcctacgcc cacggacagg
     7861 cactcggcgg aaaccgcgac cggcggcagg cgaccctggc cggcgccatc accgtctact
     7921 gggtcagcac aggcgtcctg accatgtacg tggtcgtacg tggtcaccgt catccactcc
     7981 gactgaccga gcccggtggc ggcgcgtcaa cgtctcgcct cgcgaaccat cgctcacacg
     8041 ggtggacgtc cgacatccac agcttgggaa cgctgacgac tcccgactca gcgacaccgc
     8101 cccacggcct gctaccggcc gagacgggcg acggccgtgc cgccatacgc gccaagtgct
     8161 ccgcccatgc gccctcgcgc cgaacgcgac acatccccga gctttgaggt gatgccagtt
     8221 gtccgccacg gcagtgatcc gccggtcgga ttctgaggtg tccttggaac gtggccgagt
     8281 tctcggggca cacggccacg gctttccacg tcggcgtcgt cccatcggtc ctgtcaggcg
     8341 gctcacttcg gagggctcgg gcagcggcgg gagacaggcc agggtccagt gaggattcac
     8401 gtagcgcgat gaacgaacac cgcatgacag cagaggcgtc ggcaggcgcc ggggagctgc
     8461 gcgagcgcat ggtgcacgag ttggtgcgaa gcggcgccat cgtgcatccg gcggtggaag
     8521 cggcgttccg tgccgtcccg cgtcaccgct tcgcaccgca cgtacctgcg gcggaggtct
     8581 atggagcgcc cgaagcgatc ttcaccaagc gcaccgacga cgggcgcgtc gtcagctcgg
     8641 tctcggcgcc ctggctgcac gcgcgcatgc tggaggcggc acggttggct ccggggatgc
     8701 gtgtgctgga gatcggctcg gggggctgca acgccgcgtt gttggccgag ctcgtcggac
     8761 ctgccggcgt cgtcacgagc ctcgacatcg atccggacat caccggccgc gcacgccggc
     8821 tcctggacga tgccgggtac cagcgggtac aggtgcgaac gggcgacggg gcgttgccgg
     8881 ttcccgatac tcctgccggc ggttgggacc gcatcatcgt gaccgccggg tcggccgatc
     8941 taccggaaac gtggctcgac cagctgtccg gcagcggacg gctggtcgtc ccgctacgct
     9001 tccgtggcct gtcccgcacg ttcgctttcg cgtggcgcgg agaccagctg aggagcgaca
     9061 ccacgatcgt ctccggcttt ctcgccatgc gagggaaaag cgcggacgcg ccgcgcatcg
     9121 tccggctggc cgacgaggat gtcaggctga ccgtcgacga gcgacagccc tgtgacgaag
     9181 ccgcgctccg tgcggcgttc tcctcagtcg gccacgaggt gtggacaggg gtacggctga
     9241 ccggttctga gggggtcctt cctcacctcg atgtgtggct cgccggggtg gtcgccccgt
     9301 acggccggct gcgcgcgagc cgggccgccg cggaacgggg gctggtcggt tgggtcctgg
     9361 gcaccggcgc ggcggcgatc tggaccgaca gctccctggc ctacctcgcg ttgcgctccg
     9421 caccggaaca cgccgaccag ttcgaactcg gcgtcgtcgc gcacggcccc gaccgggaag
     9481 acctcggcct cgcactcgcc gacgaggtca tccgctggaa caccactgca cgccaccagg
     9541 gcgagcccga ggtccgtgtc caccggctcg acgacctcgc acccccaggc gtcgtcatcg
     9601 agaagcccag catccggctg accatcagct gaccatcagc tgaccgcgct gcccacgccc
     9661 catcggcagc acaccgttct cccggcataa cgccagtgat cccatcagga ggagagcccc
     9721 atgacaccat cctcggcacc gtccccggca ccggcacctg aacttgccga tgccttcgac
     9781 ctggacctga ggcagcagcc cgtgagcggg ctccacgtgt ggctgagcgg tggggaggag
     9841 gagggcgaca ccaccggcga cggctgtggc gagtccccgc cccagggccc gaccaccggc
     9901 tgctgagcgc tcatcggcat ggcgggcggc cgagcgctcg tccacccggc cgtctccccg
     9961 gtccgttccc acatccacgc ttccgacgaa tggtggtgcg atgccccgca ggctgttcgc
    10021 cgctcatccg gtggccatgg cccgcgttcc gctccgcccc gaccagggag tcggcgatga
    10081 ggctgacggc ctcctgatcg agggggtcct tctcgccggg agcatcgacc tgtcgaaggc
    10141 ccggagggac gcccgcacca gggccaccct gcgcgcctac gaccttcgtt cacgcagccg
    10201 caccactccg cacggtgtct tcgccgcggt cgcaccggca gccctgaccg cccgtgccac
    10261 cacactgcgg ctgggccggg cgcaccgtgc catcaccatg ccgagcgcac gttggctgac
    10321 cgccctcgcc gaccagcttt tggacgaaca tccggaactg ctgcccaccc tcaccctgac
    10381 cacgagcaat ctggtcgcct cgcgcggcga ccgctttgtg gccgaacgcc cgacagagcg
    10441 cggcgcggag accggcagcg tgcggaacac cgaagtctcc cgctggttgc tccgtgcctg
    10501 cgcggacggc gccccggccg ccgacctgct cgccgacctc tccaaacgtc atcccgacgt
    10561 cgcccccgcc accatcgcgc gtgctgtact gaacatggtc aaggccgggg ccctgctcga
    10621 cgacctgctc cctgacgacc tccgtgccga cccgctccag cacctgctgg gtcgtctccc
    10681 ggcgcagtcg ccgtccgccc acacgctgag gcgcctggcc gcagttctcc gggaagccga
    10741 tgcgcacact cccgggtcac ctcgccgacg accactcctg tcagcggcca gggacctcgc
    10801 gaactcgctc cgccccactc cccgcccact gaccgcggac acccttgccg acgcccagat
    10861 ctccctgccg tggtcggtgg gcgacagcgc ggcgctcgcc gcctccgtcc tctggcgcat
    10921 cggtcaccgc accccaccgc tcggcgacta ccaccgccgc ttcctggccc gctacggacg
    10981 ccaccgattg gtaccactgc tcgaagcact cgaccccgta gcaggcctgg gcccgcccac
    11041 ggctcacgac gcactcggca ccgacgaggg cctcagcccg tcccgtatga ccgcactggc
    11101 ctctctgctc gccggtgccc tcagcaccgg tacgcccgaa atcgctcttc aggaccacca
    11161 cctcgcccag ctcgccaacc cgtccccgct gccgccgccc cgtaccgctg aaatccacat
    11221 ccagctgctc aacagcgaga gcgaagcccc ggacatcgcg gtcgtgcccg ggacggggtc
    11281 ccaggacgcg ggtgccgcac cgggccgctg gacccgctgg ctccccgaac tcgcccccga
    11341 cgaacacgcc ggcaacggca ccggaccgat ggtcgcggag atcgcctgcc gcacccgcac
    11401 cgctgccacc ggaacgctca acgccgagac gggcaccgcg ccttggcgca tccccctcgg
    11461 cgttccccgg cgaccggagg atctgatccc cgaggaattg gcgctggtcg tctccggcac
    11521 tcatctcgcg ctgtggtcga cccgtcacga ccgccccgtc actccggtcc tccggagccg
    11581 cgtcgcgccc cgtctgctac cgccggccgc ccgcgccctg catcttctcg gccatgccaa
    11641 cacacgcccc tggcacccct ggagctgggg cccgctgtcc gccttcccct tcacgccgcg
    11701 tgtgcgctat cacggcatcc ttctgtgccc ggcccgctgg caggtgcccg cggaactggc
    11761 caccgcggca ggcaaccgtg ctgccttcac cagcacgctg gaagtttggc agcgcactgt
    11821 tcaccccgcc ctgcccggca ccgtggtcgt ggcggagaac gaccgccgtc tcccgctcga
    11881 cctccatgac cccgacgacc gcgaactgct acgccgcagc gttcaccgag gcacccgatc
    11941 gctccacgaa cccctcgggt cgcccgaagc cctccgtgtc cttcccggcc ctgaccgtga
    12001 acgccaccac ctcgaactcg ttgtcgcact cacccgccgc gacagcccgc cctcgtcccg
    12061 gcccagcccg cgccgagcca tccgcggtgc gcacgcagga cgccaccttc ccggcggtag
    12121 ctggctgtcc gctgctcttc ccgggccgag cgacctccac gacaccacgc tcaccgaact
    12181 cagcccactg cttgagcggc tgaccaccgc gcccgacatc gaccgctggt tctggctccg
    12241 ctacaccacc ccggcgctcg gtccccacct gcgcctccgc gtccacggcg atcccaccgc
    12301 cctgaacagc cgcgtgcaac cccaactcgc caccgctacc gctcggctgc gtcggcaagg
    12361 actgtgcagc ggcctccact tggagccgta cgagcaggaa atcgagcgct acggcggcga
    12421 gcaggccatg gcctccgctg agtgcttctt ccacgcggac agcgcccttg ctctccgcgc
    12481 cctccgcctc accgacagcc aacgtctcct tctcgccgcc gcctcatccg ccgagatcgc
    12541 cggagctctc gcccccgagc agccccgacg ggccctcgcc cctggccgcc tgactcggga
    12601 ccagcgtcgc cacagagaca ccctccgcgc catcacccgc aggggtgccg cagctctcat
    12661 cccgcccttt ctggccaccg tccacgccca acggcggaaa gccctcctcg cctaccgaga
    12721 cgtcctcgcc cccgctttcg ccgccccctg cgcatccgac ctgatccaca tgcacaacaa
    12781 ccggcttctg agcaccgacc cgagccacga acgcctcgcc cgcaccctcg ccgccgatct
    12841 gcttcatcgc tcatgaccga cgagcaccgc gccctctcag ccaccaagtc ccaggagctg
    12901 gccctcgccc tcgggcctac ccgggctgtc gccgccgccg tctccgcacg cgccgcccac
    12961 acgctttgct acggactcgc cggcactgcg ctgctgcacg cctgcctcgg cgacgcgacc
    13021 accgccgtcc gccactggaa cgcagcctcc caagtcctcg gtgacgcacc ggccgacggc
    13081 atccacaccg gcccgggcgc cctcgccgct tccctgatca tcggcaccgc ccacctgccc
    13141 gagcgcggcc cccaccacgc cctcgccccg cgtgcgacga gctggctctc ggctcgtgcc
    13201 caggccctcg cccagcttca gcggacgagt ccgggatcgt gggcgccctg ggccgtctac
    13261 gacgccatca agggcttgag cggcatcggt cgcatcctcc tcgtctccca tgccaccggc
    13321 caccgcgccg aggcaacccc tggtctgcac gccgcattga ccaccctgat cagaatgatc
    13381 ctcaccgacc agggaactcg tcccggctgg tggctcccgg cccacgctca tccgccgagc
    13441 gtccctgtcc ccccatcggg cgccgccacc accggcatgg cccacggaat cgccggtccc
    13501 ctcgccttcc tcgccctcgc ccacctcgcg ggccatatcg ctcccggtca acatgacgcc
    13561 atcgccgggg ccgcgcactg gctcctcacc tgggcagacc ccggcccctc ctggccgccc
    13621 cacgtcagcg gtgccgacct cgacgccggg cccaccccgc ctcccggcgt catccccggc
    13681 cgcagaaccg cctggtgcta tggcaccccg gggatcgcca ccgccctcac gcacgccggc
    13741 cacgctctcg gtgaacccgc tttcctccgc accgccacag cggccctcga ccacctcgcg
    13801 accgacatct ccacctggga caccgaaggc cctggtcttt gccatggcgc ggcaggcgta
    13861 ctcgccggcg cccggcacgg cggttcccgg ctcgccgccc gtgcccgcga caccgtcctg
    13921 tctctgttgt ctccgccctc cgccgcgccg ggcctcctcg gcggccgtgc cggtaccgcc
    13981 ctcgccctgg ccgctgacgc cggactattc gcccgccaac gggccgcccc gtgggaaagc
    14041 gtcctgctca tctcctgacc tctccgccga ggaagatggc gcgtcactcg gcggcccacg
    14101 gcccgttccc ccgcagaccc cggcgggagg aacgggccgg tcggggcggg gggttggggg
    14161 ttggcgggtg ggtcaggtgg tcttcgtcgc gccgccgtcg atgacgtagt cgacgccgac
    14221 gatgctggcg gcggccgggg aggcgaggta ggcgacgagg tcggcgacct cgtcggggcg
    14281 tatgaaccgg ccggtgagca tgccggtggc ggccgggatc tggtcgagca gctgcgcgtg
    14341 ctccatgccc atcttctcgg ccagcgccac gccgtaccgg ccgggcccgt cccacaggga
    14401 ggtgcggacc gcgccgggcg acacggtgtt gacccgcacg ccctgggggc cgaactcctc
    14461 cgcgatcgcc ttgccgaacg cggtcagcgc ggccttggcg gtggtgtagg gcatgggact
    14521 gctgtgcggg ctcctggcgg cgtcggagga gacgttgacg acggccccgc ccccgtcctc
    14581 gacgagacgg ggcagcgcgg cccgggtggc gcggacggcg gagaggaagt tcaggtcgta
    14641 cgcctgctgc cactgctcgt cggtgaaggt gagcaggccg cccgtctgcc cttcgcccga
    14701 gtcgccgccg ccgacgttgt tgaccaggag gtcgaggccg ccgagttcgg cttctgcccg
    14761 ctcgatgagc cgggcgggtc cctcggccgt cgagaggtcg acgggcacgc agatcgcgcc
    14821 ggtggccacc agttccggcg tggtcgtgcg cgccccggcc accacccgca ttccttcgtt
    14881 caccagcgcg gcaacgacgg ccaggccgat cccccggctc gcgccggtca cgacggcggc
    14941 cttgcctgcc aggtgcagat ccatggagca ctcctcgcac aattgcgtca ggttcgacgc
    15001 gagaaccata gaagctgcaa catcgatgtt gcaagtatgg ggtgcagcgc gaccgtggcg
    15061 tagtgtttcc ggtgcctcag agggagggag cctcatggac cagagaagcg ggcggccgtt
    15121 gcgcgcggac gcggaacgga ccgtgcgggc catcctcgaa gccgcggaac gcgtgctcag
    15181 cgccgatccg gcggccacca tggagcagat cgcggaggcg gcaggtgtcg cgcggacgac
    15241 cgtgcaccgc cggttcacca gccgcgaggc gctggtcgag gcgctggcgg cctgggccac
    15301 gcggcagttc cacgaggcgg tgaccagcgc ccgcaccgac agcgttccgc cgctcgtggc
    15361 tctctaccag gtgaccgcca acgtgcttcg cgtgaagacc agttggggct tcgcgatgag
    15421 caggggaacg ccggaggacc cggaggtggc acgggtgcac gccgacgtgc tcgcccagtg
    15481 cgaccgcctg ttcctgcgcg ccgccgaggc cggcgtgctg cgccgggagg tcgacctgga
    15541 gtgggcccgc cgcgtctact acgcgctcat ccacgaggcc gcccacgacc gcggggaagc
    15601 ggccgatgac gagggcgggg acgtggaggc gctggcgacc cgcgtggtcg acacgctgct
    15661 gcgcggggtc ggcgggcgcg gcgccgaact cggcgcctga ccgggtcgcg gacagcggaa
    15721 cggcccgtca ccctcgcgcg acgcgcgggg caacgggccg tcgtccgccc tcacttgcgg
    15781 ttgtacagcc gcatcgtcag ggtgccgaac acggcgatca gcaccgcgct cgccaccagc
    15841 acccaggtga tctcgccggt gtcgacgttg ccgtccatca ggccgcgcgc ggcctcgacg
    15901 aggtgggcga cggggctgac gtcgacgaac gcctggagcc agccgggcat cgtgcccggg
    15961 tcgaccagga tgttgctgag gaaggtcatc ggcatcagca ccagcatgct gatgcccatc
    16021 acggacttct cggagcgcag catgagcccg aacatcgtcc agatccacga gaacgcgaac
    16081 gagaagacga tgagcagcag gatcgcgccc gccacgccga gcacgccgcc ctcgggccgg
    16141 tagccgagga tcaggccgac gatcaggatc accacggacg ccatggcgta cctgagcatg
    16201 tcgccgaaga ggtagccgac catcgcggcg gggcgccaga cgggaagggt cctgaagcgg
    16261 tcgaagacgc ccttctggat gtcggtgttg accgcgacgc cggtgtacat ggtggtcatc
    16321 acgacgctca tgaccatgat cccgggcagc aggaactgaa ggtactcgct cgtggacccg
    16381 gcgagcgcgc ccccgaacag gtacgtgaac atgagcgtca tcatgatcgg gaagacggtc
    16441 acgtcgaaca gctgctcggg cacgtgcttg atcttcagca tcgcgcgcca gccgaacgtg
    16501 agcgacgccg acagcgggct gggccgctgc gggcgttcca cgccggcgag caccgcgccc
    16561 agcgtctcgg cggtgggcgt gtaggtgtcc tccgcctcgt cgccgtcctt gccgctctgc
    16621 ttgggtgccg cgtcggcact ggtcgcggtg gtcatgccac ggcctcctgc ttcgtttccc
    16681 tcgtcgtggc ggtggtgtcg gtggcggacc ggtcggcctt gccgtcggtc agggcgagga
    16741 agacctcgtc gaggctcggc tggccgagcg agaagtcgtc gacgacgatg ccgcccgcgg
    16801 cgagctgggc cagggcgtgc gaggccagtt ccgcggggcc cgacgcgttg ccgtcctgca
    16861 tgagccgcgc ggtgagggcc agcgggtcgg cgtcggcgga gacggtggtg ccgaggacgc
    16921 gttccagcag ctcgcgcgcc tcggggcggc ggtcggcgtc gcgcagcctg aggtggatcg
    16981 agccggagcc gacggacgac ttcagctggc ccggggtgcc ctcggcgatc acgcggccct
    17041 tgtcgatgac ggcgatccgg ccggcgagcc ggtcggcctc ctccaggtac tgggtggtga
    17101 gcagcacggt ggtgccctgg gcgacgacgg cgcgcacgat gtcccagacc tggttgcggc
    17161 tgcgcgggtc gaggcccgtg gtgggctcgt cgaggaagag caggtcgggg gtgttgagga
    17221 tgctcgcggc gatgtcgagg cggcgccgca tgccgcccga gtagttcttc gcctgccggt
    17281 cggcggcctc ggtcagcccg aacgcgtcga gcagcgcggc ggcccgttcc cgcgcggccg
    17341 gcttgcggtg gccgaggagg cgcgcgagga gcaccaggtt ctccgtgccg gtcaggtcct
    17401 cgtcgaccga ggcgtactgc ccggtgaggc tgacgcggct gcggacggcg tcggcctggg
    17461 tgaagacgtc gagaccgaag atcctggcct cgcccgcgtc cggccgcagg agggtcgcca
    17521 gcatgcggac ggtggtggtc ttgcccgcgc cgttggggcc gaggacgccg tagacggtgc
    17581 ccgcgggcac cgtgagatcg acgccgtcga ccgcccggtt gtcgccgaat atcttgacga
    17641 gtccgcgggt ctcgatcgcg ggctcgcccg tgccgttgcc catcactgtc ctttccgtgt
    17701 ggtccgtgtg gtccgtgtgg tccgtgtggt ccgtgtggtt ttgccggcct tcgtggccgc
    17761 acgagccgca ggcgtgagcc acgtggcatt cgttcgtatg ttcgtaagac tcgggcggag
    17821 ccgcttcctc atcgccgccg gcgtgacttt tctcatcggg ttctcccgaa tccgttccct
    17881 gcgggcggcc gggctccgtc gcgcggacgg cccgcgcccc cgggcacggg cgggcggccc
    17941 ccggcgggag gcggaagcgc ccatggtaaa cggccgcctc ccgcgacgcc gctccttttc
    18001 tccgcacacc gggagggcgc gagacgccgc cgggccgccg cgagaggaga tctcgcggcg
    18061 gcccggcggg ggagcgcggg ggcggccgga tcaggaagcg gtgacgcgga ttctggactg
    18121 gccgtgcggc agcttctccc agtcctcctc gaacctggcg cgcagtccgt gccgctccgc
    18181 gagcgcgacg agcgtttccg tccggtagta gaaatcctcg cgcagcacgt ggtgctcgcg
    18241 gccctcggtg cggtcgaagg tgaagtcgaa gaacgcgccc ggcgccatga cgcggccgac
    18301 gtgcgcgagg cattcgtcga tcacggacag gggcgagtgc gagaacacgc tgtgcgcgtg
    18361 cacgacgtcg aaatacgcgt cgggcaggaa gtcgagggtg aggtcgcggg tcggcgtcag
    18421 gtgcggcacc ttgtcctgga ggccgtaggc gaccagggtg tgcttggcgc tgacgaggat
    18481 gtccggcgag atgtcgatcc cgtagtaggc gccgggcccc aggtagtcga tgaaccaccg
    18541 gcccgcgcgc aggttgccgc agccgatgtc gagcatgcgg tgctccggcc tgagaccgtg
    18601 cgcggtcagg taggtgaact gcatctcacc cagcgcccgc cagcgcgccc ggctcgcgct
    18661 gcccacggcc ttgtcggggt cgcgggcggt gtcggaggcc atcaccgcgc ggtagtagga
    18721 gacgtggtcg cggtgccgca gccgcagcca ggtgtcacgg gccacgcgcc gcgcgtgcgg
    18781 cgcgatgcgc gccggattgc gcgccgcgta acggatcttg tgggagaggc tggcccggtt
    18841 cacgagcagg gcggcgttct tcattcgcat acggggcagc ttggcgcaga tggcgctttc
    18901 cccccggaag gcgcgcgaca cgggcgcgac acttacccct ggggggtatt tgcccaacat
    18961 acccctgtgg ggtatacagg aggtcgaacg catacctccc acgggtatcc tgggcaaccg
    19021 aggagccacc ccatgacagc caccgcatcc gacagcgccg aggtcgaact ggccatcggc
    19081 ggcatgacct gcgcgtcctg cgccgcccgg atcgagaaga agctcaaccg gatggacggc
    19141 gtcaccgcct ccgtcaacta cgccaccgag aaggcgaagg tctcctacgc cgacggcgtc
    19201 accgtcgccg acctcgtcgc caccgtcgag gccaccggct acaccgccga ggagccgcgc
    19261 ccggccgccg cgcccgcgcc cgagggcggc gcggagccgc cggacgacct ggcggccctg
    19321 cgccaccgca cggcggtgac ctgggccctg gccgttccgg tgatcgtcct ggcgatggtg
    19381 cccgcctggc agttcgagta ctggcagtgg ctgtcgctga ccctggccgc gcccgccgtg
    19441 gtgtggggcg gctggcagtt ccaccgcgcc gcgtggacga acgcgcggca cggcgccgcg
    19501 accatggaca cgctcgtgtc cctcggcacg ctggccgcgc tcgcctggtc ggtgtgggcg
    19561 ctgttcttcg ggcacgcggg catgcccggc atgacccacc cgttcgagct gaccatcgaa
    19621 cgcacggacg gcgcgggcgc gatctacctg gaggccgccg cgggcgtcac cgcgttcctg
    19681 ctcgcgggcc gctacctgga ggcgcgcgcc aagcgccgcg cgggcgccgc gctgcgcgcc
    19741 ctgctcgacc tcggcgccaa ggaggtcacc gtgctgcgcg gcggcgccga gcggcgcgtg
    19801 ccggtcgcgg acctgcgccc gggcgaccgg ttcgtggtgc ggccgggcga gaagatcgcg
    19861 accgacggcg tcgtcgtcga gggcagctcg gccgtcgacg cctccatgct gaccggcgag
    19921 tccgtgcccg tcgaggtcgc ggagggcgcc caggtcaccg gcgccacgat caacgcgggc
    19981 ggccggctgg tcgtcgaggc cacgcgggtc ggcgcggaca cgcggctggc gcggatggcg
    20041 aagctcgtgg aggacgcgca gaacgggaag gccgcggcgc agcgcctcgc ggaccggatc
    20101 tcggccgtgt tcgtgccggc cgtcatcgcc atcgccgtgg ccacgctcgg cgtgtggctg
    20161 gcggcggggg gcgggccgac cgccgcgttc accgcggccg tggccgtgct gatcatcgcg
    20221 tgcccctgcg ccctcgggct cgccacgccc acggcgctgc tggtgggcac cgggcgcggc
    20281 gcgcagctcg gcatcctgat caaggggccc gaggtgctgg agaacacgcg gcgcgccgat
    20341 gtcgtgctgc tcgacaagac cggcaccgtc accacgggcc ggatggcgct gaccggcgtg
    20401 accgcggcgg cgggcgagga cgaggcggag gcgctgcggc tggccggcgc gctcgaacac
    20461 gcttcggagc acccgatcgc gcgggccgtc gccgcgggcg cggccgaggc cgcgggcacg
    20521 acggcggagc agctgccccc ggtgcgggag ttcacgaacg tgcccgggct cggggtgcgg
    20581 ggcctcgtcg aggggcgcgc cgtgctcgcg ggccgggccg ggctgctgac cggggccggc
    20641 gtcacgctgc ccgccgagct ggccgaggcg gcggccgggg cggaggccgc gggccgcacg
    20701 gccgtgctcg tcgcgtggga cgggcgggcg cgcgccgtgc tcgccgtggc cgacgcggtc
    20761 aaggacagca gcgccgaggc ggtgcggcgg ctgcgggcgc tcggcctgac gccggtcctg
    20821 ctgaccgggg acaacgagac ggtggcgcgc gccgtcgccg ccgaggtcgg catcgacgag
    20881 gtgatcgccg gggtgctgcc cgaggagaag gtggccgtcg tgcggcggct gcgggacgag
    20941 ggccgcaccg tggccatggt gggcgacggc gtcaacgacg cggcggcgct cgccgccgcc
    21001 gacctcggcc tcgcgatggg cacggggacg gacgcggcga tcgaggcggg cgacctgacc
    21061 ctggtgcgcg gcgacctgcg ggccgcggcc gacgcgatcc ggctctcgcg ccggacgctg
    21121 cggacgatca agggcaacct gtggtgggcg ttcggctaca acgtcgccgc gctgccgctc
    21181 gcggcggccg gtctgctcaa ccccatgctg gcgggcgcgg cgatggcgtt ctcctcggtg
    21241 tccgtggtcg ccaacagcct gcggctgcgc acgttccgcg ccgcgtcctg agcgcccgcc
    21301 gggcccgggc cgaggcgccg gaacgcgggg cggggcacac gccgggacac gcgcgtgaac
    21361 cgtggggtga acggggcgtg aatcccggcg ggcgcccccc atttcccccg gtgatcgggt
    21421 ggaaccgggc cgccgaccgg atacgttgac ggggtactga ctgacgacaa ccgaggtgac
    21481 aggcaatggc catctgggac cggatcaagg actcggcgaa ggggcggacc ggctccggcg
    21541 gcagcggggg gagcgggagc ggcggaagcg gcggcggcca gcagctggtg agcatgttca
    21601 agaaccagct gtcctcgatg aagacggagc tcaagagcgg cgcctaccgc gacgccagca
    21661 tggcgatgtg cgcgctggtc gccgccgccg acggctcggt cgaccacaac gagcggcagc
    21721 acgtggagtc gctgatcgtc agcaacgacg tcctccagaa cttcccggcc gactccttgc
    21781 ggcagcggtt caacaagcac gtggaccagc tcgtgggcaa cttccaggcc gggcgggccg
    21841 cggcgctcca ggagatcgcc aaggtgcaga agaagccgat ggaggcgcgg gccgtcgtcc
    21901 agaccggcat cgtgatcgcg ggcgccgacg gctacttcgc gcaggccgag cagcaggtca
    21961 tccgggaggt gtgcggcgcg ctcgggctct cccccagcga gttcaacatg tgatgacgcc
    22021 cgcgtgcgcc cgcgcacgca ctcccttacg cgccgggctc gcacgacgtg cgacacggag
    22081 ctgacggcag ccccggacaa cggaggtaag ggttccgttg ccggagtccg gggctgcctt
    22141 tgccgtttcc gatggagcgc ttgaccatcg ggggcgaggc ttgccgcatg cgcacctcac
    22201 ctgagcccca gaccgcggcg ggcgggcacc gcccgccgac cgaagccgag atccgcgcgc
    22261 tgttcgcgcg gtggaacgac gcgctcgcca ccggcgacgc ggaggtcgtg gccgaccgct
    22321 acgcggccga cgccgtcctc gaacccaccc agtccaaccg gatacgcacc gaccgcgccg
    22381 gcatagtcga ctacttcgag cacttcctca cgcagcggcc gaccggcgag atcgacgagt
    22441 cctacgtcga gatcctgggc cgcgacgcgg ccgtcgacgg cggcgcctac accttccacc
    22501 tgaccgaccc ggccacgggc gagccccgcg acgtgcgcgc ccgctacacg ttcgtctacg
    22561 aacgcgaccg gcgcaccggc acgtggctga tcgtcaacca ccactcctcg gtgatgccgg
    22621 agggctgacg ccccccggcc gcgcggcgcg gacgtgcggc ggtcaggacg gccgccgcac
    22681 gttcaggtgc aactcccgca gccgcgactc gtccaccggg ctcggcgcgc ccatcagcag
    22741 gtcctgcgcg ttgccgttga gcgggaaggc gatcgtctcg cggatgttcg gctcgtcggc
    22801 gagcagcatc acgatgcggt cgatgcccgg ggcgatcccg ccgtgcggcg gggcgccgaa
    22861 gcggaacgcg cgcagcatgc cgccgaactc gcgctcgacc tcctcggcgc tgtacccggc
    22921 gatgccgaac gccttgatca tcacgtcggg ctcgtggttc ctgatggcgc cggaggacag
    22981 ctcgatgccg ttgcacacga tgtcgtactg ccaggccagg atgtccagcg ggtccttggt
    23041 ctccagcgct tcgaggccgc cctgcggcat ggagaacggg ttgtgcgaga actcgatcgc
    23101 gccggtgtcc tcgttccgct cgtacatggg gaagtccacg atccagcaga agcggaagac
    23161 gttctcctcg aagtggccgg cgcgcctggc ggcctcgacc cgcaccgcgc ccatgatttt
    23221 ggagacctcg tcgaacgcgc ccgcgccgaa gaacacggcc gtgccgggac cggcgtccag
    23281 ccgctcgcgc agcgccgcca cgttctcctc ggtgaggaac ttggcgatgg ggccggtcag
    23341 ctgcccgtcg tcaccgaccc gcacccaggc caggcccttg gcgccctgct ccacggcgaa
    23401 ctcgccgagc tggtcgaaga agcggcgcgg ctgcttcgcg gtgtcgggca cggcgagcgc
    23461 gcgcacgtgc tggtccgcga acgccttgaa gcccgagccg gcgaagacgt cggagacgtc
    23521 cgtcagctca aggcgcgcgc gcaggtcggg cttgtccgag ccgtacttca gcatcgcctc
    23581 gcggtagggg atgcgcggga acggcgaggt gacgtgccgt ccgccgccga actccgtgaa
    23641 cagctcggtc atcacgcgct cgatgacgcc gaacacgtcc tcctgctcga cgaagctcat
    23701 ctccatgtcg agctggtaga actcgccggg cgagcggtcg gcgcgcgcgt cctcgtcgcg
    23761 gaagcacggc gcgatctgga agtaccggtc gaagcccgcg accatcagca gctgcttgaa
    23821 ctgctggggc gcctggggca gcgcgtagaa ggtgccgggg tgcagccgcg agggcaccag
    23881 gaagtcgcgc gcgccctcgg gcgaggtggc cgacaggatc ggcgtggcca gctcgttgaa
    23941 gccctgggcg gtcatcttct gccggatcgc ggagatcacg gcggagcgca gcatgatgtt
    24001 gcggtgcatg cgctcgcggc gcaggtcgag gaagcggtat tcgagccggc gttcctcg
//
