LOCUS       NZ_CP084541            22793 bp    DNA     linear   CON 20-NOV-2024
DEFINITION  Streptomyces marincola strain SCSIO 64649 chromosome, complete
            genome.
ACCESSION   NZ_CP084541
VERSION     NZ_CP084541.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces marincola
  ORGANISM  Streptomyces marincola
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 6629020)
  AUTHORS   Shi,S.
  TITLE     Strepomyces indimicinicus sp. nov., an antibiotic producing
            actinomycetes isolated from the marine environment
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6629020)
  AUTHORS   Shi,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2021) Key Laboratory of Tropical Marine
            Bio-resources and Ecology, South China Sea Institute of Oceanology,
            Chinese Academy of Sciences, 164 Xingang West Road, guangzhou,
            Guangdong 510301, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. V6.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 444.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_020410765.1-RS_2024_11_18
            Annotation Date                   :: 11/18/2024 03:45:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,763
            CDSs (total)                      :: 5,689
            Genes (coding)                    :: 5,612
            CDSs (with protein)               :: 5,612
            Genes (RNA)                       :: 74
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 77
            CDSs (without protein)            :: 77
            Pseudo Genes (ambiguous residues) :: 0 of 77
            Pseudo Genes (frameshifted)       :: 21 of 77
            Pseudo Genes (incomplete)         :: 60 of 77
            Pseudo Genes (internal stop)      :: 2 of 77
            Pseudo Genes (multiple problems)  :: 6 of 77
            CRISPR Arrays                     :: 10
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:57:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2222144
            Orig. end                         :: 2244937
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP084541.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22793
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iv"
                     /region_number="15"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /tool="antismash"
     cand_cluster    1..22793
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22793
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12793](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12793
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
     misc_feature    20..34
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.68"
                     /tool="antismash"
     misc_feature    262..277
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.79"
                     /tool="antismash"
     misc_feature    677..695
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 18.34"
                     /tool="antismash"
     misc_feature    893..908
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.79"
                     /tool="antismash"
     gene            complement(932..2368)
                     /locus_tag="LC193_RS09285"
                     /old_locus_tag="LC193_09285"
     CDS             complement(932..2368)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018538930.1"
                     /locus_tag="LC193_RS09285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_09285"
                     /product="Cys-Gln thioester bond-forming surface protein"
                     /protein_id="WP_226073237.1"
                     /transl_table=11
                     /translation="MISARRRVAPRLAATAVATGLFAAGAAATTGTAVAEENPRSGGAT
                     ATLDGLEVSDRVDVTHNGETDTYGAGLFHLTGDDGSRLMTYCIDFATRAENGARYKEAG
                     WESSTLHGNPDAGKIHWILQNSYPVVEDLGALAGQAGAESLTAEQAAAGTQAAIWEFSD
                     GVDAVPQNENARVLAEWLLESASDVAEPGASLELNPPQVSGQPGQIIGPVTVSTTADAV
                     TVAPDDAAAQQGVTIVDANGAAINGPVTDGTELYFSVPEGAEDGVAGLTATATSQVPVG
                     RAFTGIDVRTQTMILTGSDEASVSASASVNWAAPGQPSVAVNAVEKCVDGGVEVTATNT
                     GDVPFTFELEGQQYEVAPGESTPVVVPVENGQQYEITIANPIEGEEPWVFTGVLDCETG
                     EGEGQTPIDEGGEGNEENEPAPASTGGGDAADDGPDLAETGSSTNPGMIAGIAIGLLLI
                     GGAAIFFMRRRSATPSGAKD"
     gene            complement(2558..4216)
                     /locus_tag="LC193_RS09290"
                     /old_locus_tag="LC193_09290"
     CDS             complement(2558..4216)
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019432791.1"
                     /locus_tag="LC193_RS09290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_09290"
                     /product="GTPase"
                     /protein_id="WP_226073239.1"
                     /transl_table=11
                     /translation="MTETPTGDDGTLRVRLGALRELVGLSRTRLDGEVLAEAGCVLDEA
                     AARERLPTAYTAVAIAGATGSGKSTLFNALAGAQLSEAGVRRPTTATAVSCTWDAGREQ
                     GPDGLLERLGIPARARRRAHVVDTTLRGLILLDLPDHDSVDTAHRDQVDRLLSLVDAVI
                     WVVDPEKYADAVLHERYLRAFAGHAEVSLIVLNQADRLPGEAVEAVLDDLRRLLDERGL
                     ALGEHGEPGAGVLAVSALTGDGVAELRRQVGELVAARTAAGRRLAADVDGVARRLGPVY
                     IADGADAPAGLTARAREEFEDGLAAAVGAPAGGQAAERAWLRRADRACGTPWAQVARRL
                     AAHQAERRGEPPALAAKRLRAAGPPVVARAAVDQAVRQVAADAADGLPRPWARAVRDAA
                     RRGGEGLPRALETALERNPAAPPPRPRWWSVAGAGQAVLLAAQFLGLCWLVTAFVGQPV
                     VGRWLPLALLVGGSVGGPLLAWGCRAAARGPARAWGQQEEWRLRRLAADRGHTQVLEPV
                     AAELMRYREVRERYVIAASADGGQDGGAGVSVPIR"
     gene            complement(4252..5820)
                     /locus_tag="LC193_RS09295"
                     /old_locus_tag="LC193_09295"
     CDS             complement(4252..5820)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019886402.1"
                     /locus_tag="LC193_RS09295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_09295"
                     /product="dynamin family protein"
                     /protein_id="WP_226078527.1"
                     /transl_table=11
                     /translation="MDARPELLDALTVLRERLAAVRFPLDLPGAERARRSAAELLAQLD
                     GYLLPRLRQPEAPLLAVVGGSTGAGKSTLVNSLVGRRVTEAGVLRPTTRTPVLVCHPDD
                     ERWFTGRRVLPQLGRVCGPRQESDRPDALAVVTTRALPAGLALLDAPDIDSIVAGNRDL
                     AADLICAADIWVLVTTAARYADAVPWHLLRSAKEYDVTLATVLDRVPHQIAAEVSRHYG
                     ALLERAGLGEVPRFTVPELPESAANSGLLPATAVAGLREWLGRRAQDPQARSLAATRTA
                     AGALAALRARVADLAGACAAQYATAVRLDQRLADAYAEADRRVRACLAGGGLLTGQAGA
                     HWLAFPEDAGADELSDALAQALAGLLVEAVSAADEHTDAAWQREPGAPEGGADGQDAVA
                     ERVGVLVRRLRRCLDELAEEAAQAAGGTRGEPGDEGETAALLAASLLGGKAGGVAQQAL
                     AGILGSRNASRLRDRGAAELRRCVERALTAERLRRGAPLHRLNITAEPQVELVAALSSV
                     RAHQG"
     tRNA            6130..6202
                     /anticodon=(pos:2228307..2228309,aa:Arg,seq:tct)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="LC193_RS09300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="LC193_09300"
                     /product="tRNA-Arg"
     gene            6130..6202
                     /locus_tag="LC193_RS09300"
                     /old_locus_tag="LC193_09300"
     misc_feature    complement(6439..6455)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 14.84"
                     /tool="antismash"
     gene            6936..7817
                     /locus_tag="LC193_RS09305"
                     /old_locus_tag="LC193_09305"
     CDS             6936..7817
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (39-205). E-value: 6.8e-10.
                     Score: 31.1. Matches aSDomain:
                     nrpspksdomains_LC193_RS09305_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018835102.1"
                     /locus_tag="LC193_RS09305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_09305"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_226073241.1"
                     /transl_table=11
                     /translation="MSRRAAVGAAAGLAFGAAATTGTAHAAGRDRGGDRFRGQSVLITG
                     ATSGIGRAAAVAFAREGAKVAFCGRRERAGRAVEREIRQNGGEATYFRADVRRAEDVRS
                     FVTRAVRTYGGPDIALNNAGIQLPFTDLHEVSVAEWDEVASTNIRGVFLAMKYQIPFMR
                     EAGGGVILVTGSSNQFATRTGLASYTAAKNGVTGLVQAAALENAAHGIRVVAISPGMTD
                     TEMLDAHRPAGISDEEWRATKAAFAEQGVDAMKRMAEPEEIAAAALALASDAFSFQTGT
                     SIPVDGGQLAAL"
     CDS_motif       6954..7016
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_LC193_RS09305_0001"
                     /evalue="9.90E+01"
                     /label="PKSI-ER_m5"
                     /locus_tag="LC193_RS09305"
                     /protein_end="27"
                     /protein_start="6"
                     /score="-4.1"
                     /tool="antismash"
                     /translation="VGAAAGLAFGAAATTGTAHAA"
     CDS_motif       7053..7148
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_LC193_RS09305_0002"
                     /evalue="4.60E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="LC193_RS09305"
                     /protein_end="71"
                     /protein_start="39"
                     /score="22.5"
                     /tool="antismash"
                     /translation="SVLITGATSGIGRAAAVAFAREGAKVAFCGRR"
     aSDomain        7053..7550
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_LC193_RS09305_PKS_KR.1"
                     /evalue="6.80E-10"
                     /label="LC193_RS09305_PKS_KR.1"
                     /locus_tag="LC193_RS09305"
                     /protein_end="205"
                     /protein_start="39"
                     /score="31.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="SVLITGATSGIGRAAAVAFAREGAKVAFCGRRERAGRAVEREIRQ
                     NGGEATYFRADVRRAEDVRSFVTRAVRTYGGPDIALNNAGIQLPFTDLHEVSVAEWDEV
                     ASTNIRGVFLAMKYQIPFMREAGGGVILVTGSSNQFATRTGLASYTAAKNGVTGLVQAA
                     ALE"
     gene            complement(7862..9541)
                     /locus_tag="LC193_RS09310"
                     /old_locus_tag="LC193_09310"
     CDS             complement(7862..9541)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015649.5"
                     /locus_tag="LC193_RS09310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_09310"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_226073243.1"
                     /transl_table=11
                     /translation="MAFRVLGPVELLSSEGMELPLSGRLRDTAALLTVRPNTFVATETL
                     ADGLWGGSPPRGAATTVRTYIHGLRKTFDRYAPGQVIETRAGGYLLPVTPEALDASRLR
                     DLLRRGLRARGDGRLRMAESLLDEAVSLWRGRPYTGVAPDVLLHETTAELECHYRAAVL
                     ARAAIRLASGRAADAVTDLRGLAVSFPTDEQVAEELIRALRSDGRDPEAAEAYRTFAAR
                     LAAEHGAVPARGLRSAALDGAHFSAPTSSAAPPPVTPLIGRDGALRRVLDSTSARAEGR
                     EHRVTVICGPPGIGKSALALHAAHRRGAWSGANGGTVAYVDLHQCTSPGEAWQRVDGLG
                     ERPDLLLLDGVRDPEVGRAALAAGSARTVLVTSRRPLAALRAHSLVRLSGLGRSSAIRF
                     LRDCVGAERVDAEPEAAEAIAVACDGHPLALHIAAVKLALCPTRPLSRLAGRLADPRHL
                     LNELQVDGLAMRPLAEAAIARCTKSQRLWLRRLARHGRHRLTAADAAGLAAVTVAEAEA
                     ALDGLTEHGLLCADPGGGGGYRVSSLVRAALTEPRRGPQPAK"
     gene            10001..12793
                     /gene="lanL"
                     /locus_tag="LC193_RS09315"
                     /old_locus_tag="LC193_09315"
     CDS             10001..12793
                     /codon_start=1
                     /gene="lanL"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038150.1"
                     /locus_tag="LC193_RS09315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_09315"
                     /product="class IV lanthionine synthetase LanL"
                     /protein_id="WP_226073245.1"
                     /sec_met_domain="Pkinase (E-value: 4.5e-14, bitscore: 50.8,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.3e-40, bitscore:
                     137.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSHHHEAAGHGDEHDYVDDFLAVRDAVAPLRGWRHLPEEMWCYV
                     TPPDSEFRAQGWKIHVSATPRSAVPVLRAASRVLLEHKAAFKFAKSLSRLRMLLSIRMD
                     RGAGGKFITVYPSSDEQFTDLLQALHRATEGLEGPAILSDRRYLPDSLVHYRYGGFSAG
                     QQVLDVDGAYVPMLVAPDGSWSKDERTAWFSPPPWASAPRLPEGVEQPGPVRRQRSKGQ
                     VLLNDRFVVFEAIRHSNRGGVYRALDRHDGDRRVIIKEARPFVAAETCGTDARDYLRNE
                     YRTLSLLEPLGIAVKPVDLFEYQGHSFMAEEEVPGVPLRDWVAERIRNEPSRALPLDAV
                     LPVARRVVALAGAAHDKGLVLRDFTPNNIMVTPGGELVLIDTEFAAIPGETTTRIQTPS
                     YTAPEEIGGPTRYPAPSHEADLYSVGATLFYLCTGVNPVVANDGFAAEPGRKPPVRPHD
                     ERVERMVAGVAADVPSLAALAPAVLGLMREDPTRRTGLVQVLDLLDTPRVPVPAAAPHR
                     LSAADRDRLLADGTAQLVAAMTPESRRSLWPAPPMEGRQFDTLAVQAGSGGTLEVLRRA
                     ALRAEGAEGGERLAGGELTEALRTALTWLDRHADDERRQLPGLYFGRAGTYWAMYEAAA
                     ALGEEEIGRRSVDRAKRLSVNWTNPDMTHGMAGNGLAQLRLWRRTGDEEFRVRAELCVE
                     AVLGARSEDGTTWPVPAAMGQVSGLTHYGFAHGVAGVGAFLVVAARELGRPDLLDIATS
                     SGDLLLSLARRQGESLAWPTAQHEPEDAEKFDGVCWWCSGAPGIGTFLIRLWRATGEDR
                     FLEAAHGAAVATRRERWLLLASHCHGVAGNGEFLLDMAAATGERRYRDWAAEHAASLYR
                     LSALHEGRLVVLDETNSALTYSYGVGMAGAIGFLHRHRHGGERWWMVDDFTLEPEGESR
                     "
     gene            12790..14709
                     /locus_tag="LC193_RS09320"
                     /old_locus_tag="LC193_09320"
     CDS             12790..14709
                     /EC_number="3.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.5"
                     /locus_tag="LC193_RS09320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_09320"
                     /product="S9 family peptidase"
                     /protein_id="WP_226073247.1"
                     /sec_met_domain="PF00561 (E-value: 1.1e-06, bitscore: 26.8,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_S9 (E-value: 1.3e-29, bitscore:
                     101.6, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAVTAAAATSAPGTGAVPGAAPGAAMPRLWPLLTSLRSRFSFRF
                     STTGRAAAALVADGRGVLFCEFWDLADEAGTAPTCRVVPGFSRPARAEDDPASLPSDAL
                     PFDDGSVLVVARTGLELVTAAGARTAAGRLPFRPVVTAPAPGGRPGALFLGRDDAGAWS
                     AWWWDPSAAGARRVGGVPPLTLPRGGGWLDEGATRFALNAPSPAGPGPTAPAVLTVPEG
                     RLEPLPVGDPSEHDMVWHTVPRTGESLLVGTDGSAHALRLSGPGGTRRLTAADALTGSV
                     TPLALDASGTLLALHERVGQRDRLTVLDTVRDALLDLPERGDTLYAHATWTETGSGTPG
                     LLAFVADAGRPARVAGTAPGAEGWTHVTDGTEAGDHDAYAPGHLERLPGAAGDIEAVVC
                     GHQDWRTARGVVLCLHGGPADHWALKFSLLFQFLADLGLTVIAPNPRGSTGYGDAFHRT
                     VVGAWGGPDLDDVLAIARHLRAERRTPEGLALYGASYGAFLALLAAATEPELWSRTLAV
                     APMLGGRRLHPEADASVRALIDRLDGHAVVDDHLGPRDPLARLSRITAPLAVIHGADDP
                     TIPPGQSRRLVAELRRLGRRPGTDFHHVEVPGAGHSPLDGSAELHHTAALFLAEGVWTG
                     PATT"
     gene            14770..14910
                     /locus_tag="LC193_RS09325"
                     /old_locus_tag="LC193_09325"
     CDS             14770..14910
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LC193_RS09325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LC193_09325"
                     /product="hypothetical protein"
                     /protein_id="WP_226073248.1"
                     /transl_table=11
                     /translation="MTIAIEALQELEETESGLADCPIGSCCGAWLPVPTAFTCFGNTFG
                     S"
     CDS_motif       14770..14829
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTIAIEALQELEETESGLAD"
                     /locus_tag="LC193_RS09325_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       14830..14910
                     /prepeptide="core"
                     /locus_tag="LC193_RS09325_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="-2.10"
                     /molecular_weight="2546.9"
                     /monoisotopic_mass="2545.1"
                     /core_sequence="CPIGSCCGAWLPVPTAFTCFGNTFGS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTIAIEALQELEETESGLAD"
                     /leader_location="[14769:14829](+)"
                     /alternative_weights="2565.0"
     gene            14966..15121
                     /locus_tag="LC193_RS09330"
                     /old_locus_tag="LC193_09330"
     CDS             14966..15121
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LC193_RS09330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LC193_09330"
                     /product="hypothetical protein"
                     /protein_id="WP_226073249.1"
                     /transl_table=11
                     /translation="MSLAIEELQELEATEEAALAANNCCWNSIINGCQWQSFAILSTCH
                     GCTNSN"
     CDS_motif       14966..15031
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSLAIEELQELEATEEAALAAN"
                     /locus_tag="LC193_RS09330_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       15032..15121
                     /prepeptide="core"
                     /locus_tag="LC193_RS09330_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="1.00"
                     /molecular_weight="3097.4"
                     /monoisotopic_mass="3095.3"
                     /core_sequence="NCCWNSIINGCQWQSFAILSTCHGCTNSN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSLAIEELQELEATEEAALAAN"
                     /leader_location="[14965:15031](+)"
                     /alternative_weights="3115.5"
     gene            15175..15300
                     /locus_tag="LC193_RS28955"
     CDS             15175..15300
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LC193_RS28955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_264086262.1"
                     /transl_table=11
                     /translation="MTTLILDLQELEATENPAFDEVQGCCGLGTLLTCPTRTFDW"
     CDS_motif       15175..15243
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTTLILDLQELEATENPAFDEVQ"
                     /locus_tag="LC193_RS28955_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       15244..15300
                     /prepeptide="core"
                     /locus_tag="LC193_RS28955_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="7.10"
                     /molecular_weight="1872.2"
                     /monoisotopic_mass="1870.9"
                     /core_sequence="GCCGLGTLLTCPTRTFDW"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTTLILDLQELEATENPAFDEVQ"
                     /leader_location="[15174:15243](+)"
                     /alternative_weights="1890.2"
     gene            15392..17155
                     /locus_tag="LC193_RS09335"
                     /old_locus_tag="LC193_09335"
     CDS             15392..17155
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.5"
                     /locus_tag="LC193_RS09335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_09335"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_226073250.1"
                     /transl_table=11
                     /translation="MPTASPAQPAPPTRAAPSGDRLLARLLRGTRALTALYLVAAAASA
                     ATALLLPAALAAAVNAAVGRTSATTPVVLTVLLLAIAALAEVAAELAQVRTSTRGAAWL
                     RHDLLRHMVRLDLRGQRRFPAGDVLSRLLQSTSQTANLVPTVVGGLMSGLVSVGAIAAL
                     FLIDPGSGLIFLLGAPVVWLVAKGFFHRTTALTEGYQRAHGELAGRFLEAVRGIRTIRA
                     AGTADRETERVLEPLPRLRLHGERFWLAQRDAGWRISLVVPVLQIGVLATAGHGVASGR
                     LAPGDLLAVTGYLGQAFGVFAQIGVIASLGQVRGSANRIREVLAAPPAPSGSRAFPPGG
                     GALRLSGVRVLADGKPLLDGVDAELPAGSEVAVVGESGTGKSTLAALAGGLLHPDAGTV
                     TLDGVDLAAADPAALRREIACAFERPVLLGATVRDAIGYGDEPVDGTALARGLRDSGAR
                     EFVSKLPRQLDTPLGDLRASGGEYQRLGLARAFCRNARLLVLDDATSSVDVITERRIAR
                     ALRNHPATRLVVTHRVSTAARADLVLWLHEGSVAAVGPHSELLALPGYAALFGEAVGSA
                     GQARETTGARP"
     gene            17152..18879
                     /locus_tag="LC193_RS09340"
                     /old_locus_tag="LC193_09340"
     CDS             17152..18879
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.5"
                     /locus_tag="LC193_RS09340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_09340"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_226073251.1"
                     /transl_table=11
                     /translation="MSERTTRRAGTRAGLALIRPALRAERRSIAALALWSVVEAAPTLL
                     SGWIIGRAVDDFLAGEVTAALVLLAVYGVAMLAAAVSTRQVMGPLARIVEAVRDRLVGT
                     VVESALLSAVRHGTTPDAGTVARTTRQTESVRGLMAGLLMSARGVAFSVPAVVVGLFTI
                     APVIAALTLASLAVSCALLVLVSRVLRRRLVVSLTAEEELAENAGRLLDGLRDVAACGA
                     PRRAAGETGRAVEAQAAASMATAWAEAGRIGVIVTGARLPLVGTLLLAPGLISSGHLTP
                     GEVVGVATYLVTGLEPAVRTIVQNLAGLGLHLGVVLRRLAERTALPASPATASAAPPAG
                     PAELTLHGVTFAYGPHSAPVLDNLDLRIPVGDHLAVVGPSGAGKSTFSSLLCGLLPPDA
                     GEVRLGGRPLSGIDPRRLREAVVLVPQESYVFTGTVRENLGYLCPTEPDDGPLNEAIDL
                     FALRAAVERLGGPDAVIDEPGALSEGERQLIVLARAYLAPAGTVVLDEATCHLDPVREA
                     RAEEAFMARPGTTLVVIAHRTSSARRAKRVLVLESGTAVVGARGALAGVSPLLDDLMR"
     gene            complement(18924..19661)
                     /locus_tag="LC193_RS09345"
                     /old_locus_tag="LC193_09345"
     CDS             complement(18924..19661)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015649.5"
                     /locus_tag="LC193_RS09345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_09345"
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_226073252.1"
                     /transl_table=11
                     /translation="MRFQILGPLRVRCGQRWQPVSAAKQRHLLAVLVVRRDTALPVTEL
                     VGELWPNQPPETAPALIRNYVMRLRRLLGDEDGPVIERQSCGYRLIAPPGAADTDADAF
                     GAALERAGERLEHGEQNAARAQLRGALALWRGEVLADVPATGMLAPVRASLTEAREVAR
                     DRLIESELARDAAAVVPELRSLVGDGCLREHRWAQLMRALWLTGRRAEALSCYRQIRSV
                     LREQHGIEPGPELSDLHVRLLRA"
     gene            19921..22773
                     /locus_tag="LC193_RS09350"
                     /old_locus_tag="LC193_09350"
     CDS             19921..22773
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013124.5"
                     /locus_tag="LC193_RS09350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_09350"
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_226073253.1"
                     /transl_table=11
                     /translation="MDIRLLGPVELHREDRPVVVGAPMLRTLLAVFAVRPGQLRSAASL
                     CDQLWGTTPPSSRATLRTYVMRLRRLLPDGRLRRVPSGGYVLDAAPEETDLGRFRTRLA
                     LARGLAETRPDEALRAYEAACLLWRGEPLAGLGDGPFAAAEAPRLAALRLDAQEERFAV
                     HLRLGRHAEILDELAAEARAHHLREGLTRHLMLALHRSGRTSEALDAYRSLRRRLVEDL
                     GIEPGHELRAVEQAILRADPALLLPGPGAPPNLAAGPRSKAAAPALPGAIAPAFPAAVG
                     TFVARAGELALLGEWLDPAATAPGVCLLDGPGGVGKSALAVLAARKSAARFPDGLLHVD
                     LRGADPDDAPLDVAVAAQLLLSQLGVPMREVPQEAEEAAARFRVRLRGRRCLVLLDNAR
                     DAAQVRPLLPDDAPAVVLVTSRMALTGLAGGRHLHLGLLDRADSVRLLRTIAGPRTVCA
                     TPAQWAELAGLCGDLPLALRIVAARMAARPGWEVAEWIALLRDERGRMDQLRTADLDLR
                     AGLMVGIDRLAGSEDPADRQAAALFPLLGVPALHTYRPASAAALAGCTPAEAEDSLERL
                     TDARIADSPRSGVYVLHDLLRAAARWQADRLPPEHARERLGALARWYLGTLHRAGTRLS
                     SAGWLRSRVRQGIARFPDGDDFPDSESALAWADTAVPQALTLAEQCAAPEYRDGTELAG
                     RPLSTFGLSAARALTGYFALRMNLRDQRRLATLVLRTAERDGDAFARGFALGQLGKVLG
                     QSGDVEGGLPLLSESWDVLTRMGEVREAIASASNLVGCLGQARRPEEAIRAGRRALAAA
                     ESADLVEARITIGTNMGHAHYLAGDLVSARRVLIEVCSAAPEPTAVLSSTLASLAACEL
                     AAGDHAEAARWARTGLALVERHPVDPLSRAELHSLLASALRVSGDERAARAESAVALRL
                     VDELNARENLHLRIPDPGPA"
ORIGIN
        1 cggccccggt cgagttcgag gatccactcg gcgacgttgt ccaggaagta ccggtcgtgg
       61 gtgatggcca cgacggtgcc cgggtacttg gccaggtgct gctcaagcca ctgcacggac
      121 tcggcgtcga ggtggttggt cggctcgtcg agcagcagca ggtccggctg ttcgagcagc
      181 agcttgcaca gcgcgacgcg gcgcttctcg ccgccggaca ggttggtgac gggccagtcg
      241 ccgggcgggc agcccagggc gtccatggcc tgttcgagct gggcgtccag gtcccacgcc
      301 ccggcgtggt cgagctgctc ctggagcgcg cccatctcct ccatcagcgc gtcggtgtac
      361 tcggtcgcca tctgctcggc gatctcgttg aaccggtcga gcttggcctt ggtctcggcc
      421 acgccctgct gcacgttctc caggaccgtc ttcgactcgt cgagcggcgg ctcctggagc
      481 aggatgccga cggtgtggcc cggcgtcagg aaggcgtcgc cgttcgacgg ctgttcgagg
      541 cccgccatga tcttcagcac cgtcgacttg ccggcgccgt tcgggccgac gacaccgatc
      601 ttcgccccgg gcaggaagct cagggtgacg tcgtcgagga tcaccttgtc gccgtgcgcc
      661 ttccgcgcct tgcgcatggt gtagatgtac tcagccaaga gaaaccgtcc ggcagatcag
      721 tgtggcatca ggcaggtgtg cctccatcct gccgcatgcc cgggccgcgg cggaaaccgg
      781 cggtgcgcgc ggggcccgcg ggcccgcggg gcggtcccgg tgcggaacgg gcccgcggcg
      841 ggacggcaca cgaagggggc gggcccgtgc gggcccgccc ccggtgtccg gcgtcacgcc
      901 ccgctcacgg gggtgcgcac ggtggtgtcg ctcagtcctt cgcgccggaa ggggtcgcgg
      961 acctgcggcg catgaagaag atcgccgcgc cgccgatgag caggaggccg atcgcgatgc
     1021 ccgcgatcat gcccgggttg gtgctgctgc cggtctcggc caggtcaggg ccgtcgtccg
     1081 cggcgtcgcc gccaccggtg ctggccgggg cgggctcgtt ctcctcgttg ccctcgccgc
     1141 cctcgtcgat cggcgtctgg ccctcgccct caccggtctc gcagtcgagg acaccggtga
     1201 acacccaggg ctcctcgccc tcgatcgggt tggcgatcgt gatctcgtac tgctggccgt
     1261 tctcgaccgg gacgacgacc ggggtcgact cgcccggggc cacctcgtac tgctggcctt
     1321 cgagctcgaa ggtgaacggg acgtcgccgg tgttggtcgc ggtgacctcg acgccgccgt
     1381 cgacgcactt ctcgaccgcg ttcaccgcga cggacggctg gccgggagcg gcccagttga
     1441 ccgaggcgga ggcgctgacg gacgcctcgt ccgagccggt caggatcatg gtctgggtgc
     1501 ggacgtcgat gccggtgaag gcacgtccga ccggcacctg ggaggtggcg gtggcggtga
     1561 ggccggccac gccgtcctcg gcgccctcgg gcacggagaa gtacagctcg gtgccgtcgg
     1621 tgacgggccc gttgatcgcg gcgccgttgg cgtccacgat cgtcacgccc tgctgggccg
     1681 ccgcgtcgtc cggggcgacg gtgacggcgt cggcggtcgt gctgacggtc accgggccga
     1741 tgatctgacc gggctggccg gagacctgcg gcgggttgag ttcgagcgag gcgcccggct
     1801 cggccacgtc ggaggcgctc tccagcagcc actcggccag gacgcgggcg ttctcgttct
     1861 gcggaacggc gtccacgccg tcggagaact cccagatcgc ggcctgggta ccggccgccg
     1921 cctgctcggc cgtgagcgac tcggcgccgg cctggccggc cagcgcgccg aggtcctcga
     1981 cgaccgggta ggagttctgg agtatccagt ggatcttgcc ggcgtcaggg ttgccgtgca
     2041 gggtggagga ctcccagccc gcctccttgt acctggcgcc gttctcggcc ctggtggcga
     2101 agtcgatgca gtaggtcatc agccggctgc cgtcgtcgcc ggtcaggtgg aacaggccgg
     2161 cgccgtaggt gtccgtctcg ccgttgtgcg tgacgtcgac ccggtcgctg acctcaaggc
     2221 cgtcgagcgt cgcggtggcg ccaccgctgc gcgggttctc ctccgcgacg gccgtgccgg
     2281 tggtcgccgc cgcgccggcg gcgaacagac ccgtggcgac agcggtggcc gcaaggcggg
     2341 gggcgacccg cctgcgcgca gaaatcatgt gtaagtcccc tccacggaat cacagggcgc
     2401 agcggtcgtg aacacgaccg cacgctcaac aacatccccg tgcgtggggg atcgtagaga
     2461 ggcaaggtgt caatttctcc accggggcgt ggacttacac attccgaggg cgaatcgtta
     2521 ccttgcggcg ccgaactgcg ccgattatgg ccggatttca tctgatgggt accgacactc
     2581 cggctccccc gtcctgcccg ccgtccgccg acgcggcgat cacgtagcgt tccctgacct
     2641 cgcggtagcg catgagttcc gcggccaccg gttcgaggac ctgggtgtgg ccgcggtcgg
     2701 ccgccagccg ccgcagccgc cactcctcct gctggcccca cgcgcgcgcc gggccgcggg
     2761 ccgcggcgcg gcagccccag gcgagcagcg gaccgcccac cgagccgccc accagcagcg
     2821 cgagcggcag ccagcggccc acgacgggct gcccgacgaa cgccgtgacc agccagcaca
     2881 ggccgaggaa ctgcgcggcg agcagcaccg cctgccccgc ccccgccacc gaccaccagc
     2941 gggggcgggg cggcggggcg gcgggattgc gttccagcgc ggtctccagg gcccgcggca
     3001 gcccctcacc gccgcgccgc gccgcgtccc gcaccgccct ggcccacggc cgcggcagcc
     3061 cgtcggccgc gtcggccgcc acctgccgca ccgcctggtc caccgcggcc ctggccacca
     3121 caggcggccc ggccgcgcgc agccgcttgg cggccagcgc gggcggctcg ccgcggcgct
     3181 cggcctggtg cgcggcgagc cgccgcgcga cctgcgccca cggcgtgccg caggcgcggt
     3241 cggcgcggcg cagccaggcg cgttccgcgg cctgcccgcc ggccggcgcg ccgaccgccg
     3301 cggccaggcc gtcctcgaac tcctccctgg cccgcgcggt cagcccggcc ggcgcgtcgg
     3361 cgccgtcggc gatgtacacg ggcccgaggc ggcgggccac gccgtccacg tcggccgcga
     3421 ggcggcgccc ggccgccgtc cgcgcggcga ccagctcgcc cacctggcgg cgcagctccg
     3481 cgacgccgtc cccggtgagc gcggagacgg cgagcacccc ggcgcccggc tcgccgtgct
     3541 cgccgagcgc gaggccgcgt tcgtccagca gccgccgcag gtcgtcgagc acggcctcga
     3601 cggcctcgcc cggcagccgg tcggcctggt tgagcacgat cagcgacacc tccgcgtgcc
     3661 cggcgaacgc gcgcaggtag cgttcgtgca gcaccgcgtc cgcgtacttc tccgggtcca
     3721 ccacccagat cacggcgtcc accagggaca gcagccggtc cacctggtcg cggtgcgcgg
     3781 tgtccaccga gtcgtggtcg ggcaggtcga gcaggatcag gccgcgcagc gtggtgtcga
     3841 cgacgtgcgc cctgcggcgc gcccgcgcgg ggatgccgag gcgttcgagc agcccgtcgg
     3901 ggccctgctc ccggcccgcg tcccacgtgc aggacacggc ggtcgccgtg gtcggccggc
     3961 gcacgcccgc ctcggacagc tgcgccccgg ccagcgcgtt gaacagcgtc gacttgccgc
     4021 ttcccgtggc gcccgcgatg gccaccgccg tgtacgccgt gggcagccgc tccctggccg
     4081 cggcctcgtc gagcacgcat cccgcctcgg ccagcacctc gccgtcgagc cgggtgcggg
     4141 agagccccac cagctcgcgc agcgcgccga gcctgacccg gagggtgccg tcgtccccgg
     4201 tcggcgtctc cgtcatgtcc tgtcctctcc acggtggtgt gcgggtgccg ctcagccctg
     4261 gtgcgcgcgc acggacgaca gcgcggccac cagctcgacc tgcggctccg cggtgatgtt
     4321 cagccggtgc agcggggcgc cgcggcgcag ccgttccgcc gtcagcgccc gttcgacgca
     4381 gcgccgcagc tcggccgcgc cccggtcgcg cagccgggag gcgttgcggg agccgaggat
     4441 gccggccagc gcctgctgcg cgacgccgcc cgccttgccg ccgagcaggg aggcggcgag
     4501 cagcgcggcg gtctcgccct cgtcgcccgg ctcgccgcgc gttccgccgg ccgcctgcgc
     4561 cgcctcctct gccagctcgt cgaggcagcg ccgcagccgc ctgaccagca cgccgacgcg
     4621 ttcggccacg gcgtcctggc cgtccgcgcc gccctcgggc gcgccgggtt cgcgctgcca
     4681 ggccgcgtcg gtgtgctcgt cggccgcgga aacggcctcg accagcagcc cggcgagcgc
     4741 ctgggcgagc gcgtcggaca gctcgtccgc gccggcgtcc tcggggaacg cgagccagtg
     4801 cgcgcccgcc tgcccggtca gcaggccgcc gccggcgagg cacgcgcgca ccctgcggtc
     4861 cgcctctgcg taggcgtccg cgagccgctg gtcgagccgc acggcggtgg cgtactgcgc
     4921 cgcgcaggcc ccggcgaggt cggcgacccg ggcgcgcagc gcggccagcg ctccggccgc
     4981 cgtgcgcgtc gcggcgagcg agcgcgcctg ggggtcctgc gcgcggcggc cgagccattc
     5041 ccgcagcccg gcgacggcgg tcgcgggcag cagccccgag ttggccgcgg actcggggag
     5101 ttcgggaacg gtgaaccggg gcacctcgcc gagcccggcg cgttcgagca gggcgccgta
     5161 gtgccgggag acctcggcgg cgatctggtg cggcacccgg tcgagcacgg tcgcgagggt
     5221 cacgtcgtac tccttggcgc tgcgcagcag gtgccaggga acggcgtcgg cgtaacgggc
     5281 cgccgtggtg accagcaccc agatgtcggc ggcgcagatc aggtcggcgg ccaggtcgcg
     5341 gttgcccgcg acgatggagt cgatgtcggg ggcgtcgagc agggcgagcc ccgcgggcag
     5401 ggcgcgggtg gtgacgacgg cgagcgcgtc cgggcggtcg ctctcctggc ggggcccgca
     5461 gacccgcccg agctgcggca gcacgcggcg gccggtgaac cagcgctcgt cgtcggggtg
     5521 gcacacgagc acgggcgtcc tggtcgtggg gcgcagcacc ccggcctcgg tgacgcggcg
     5581 cccgacgagc gaattgacga gcgtggactt gcccgccccg gtcgacccgc cgaccacggc
     5641 gagcagcggc gcctccggct ggcgcagccg gggcagcagg tacccgtcga gctgggcgag
     5701 cagttcggcg gcggaacgcc gggcccgttc cgcccccggc agatcgagcg ggaagcgcac
     5761 agccgcgagg cgctcccgca gtacggtcag cgcgtcgagc agctcgggcc gtgcgtccaa
     5821 gatcgccaca tgcgcagaat gcctaatttc gagcggtttc aaaagcatat tccgccgaac
     5881 gcgccccaaa ccgggcagcc ggcggcccgc cccggccgcg gctctggcat aacgagtgcg
     5941 caacaccgca cgcggacgcc accaaaatcg ctgcgcttgt cgcactcgcc tgcgattatc
     6001 ggggctgctt caccggatct ccacacgagg gggccgccgt gaagcaaccg ggacgaaccc
     6061 ctcgaagctc tatcctgtgc gcggcgaggt cacttcaggg gccaccgtcc cacgccatga
     6121 ccaagaccgg cccccgtagc tcagtggata gagcaggtgc cttctaagca cttggccgca
     6181 ggttcgagtc ctgccggggg cgcaccgaag agggctggtc aacggcccgg ggagcggccg
     6241 aggggtgcgc tgcggcggtg atgtccgcca catcggcggc cagggcttca ctgatcgtca
     6301 cctgtaggtg aaggctccgg tcccggctgt cgtagcgggc ccggagccgg aaggcgccgt
     6361 agatctcgcg ctggaggcgg accgggcagc cgagtggtga gctgggctgt ccgcggttcc
     6421 tgccgttcgg ggccgaggat gtgctcttcg aagacaccgt gcgcggcctc cagcacgcgg
     6481 cgcaccgatc cacaccgcct cgggtgagcg ccgtgccagt cggcggcgtg gtggtgggca
     6541 tgggagatcc gcccttcggg gtgctgccga acatgcggcg cgcagcatgc agagaacgtg
     6601 tgagtgcagc gtgcgggtgt gcgccgcccg gcgggcgggc gtgcgctgat gccggcctcc
     6661 gcgcgacggg gaacgggcgg tgcgtgcctg cgcgggtcct tcttcaaccg gtcggctccg
     6721 ctgagggtga gtgccgttcc cccgccgttc ccccaccggt accgaaccag gccgctgctg
     6781 acaccgggcc ggtccgtgcg ggccgagggc ccgtcgccgt tccaggtggg cttccagcag
     6841 gtggtcagcg gcgacgcgca ccctgctggt gaacctttcc agccgaacac gaggtgaaga
     6901 tcgcgatggg accaagcgag cagaccgacg gtcggatgag tcgacgcgca gcggtgggcg
     6961 cggcggcggg actcgccttc ggcgccgccg ccacgaccgg caccgctcac gcggccggcc
     7021 gggaccgcgg cggggaccgg ttccgcggcc agtcggtcct catcaccggg gcgacctcag
     7081 gcatcggcag ggccgccgcc gtcgccttcg cccgcgaggg cgccaaggtc gccttctgcg
     7141 gacgccgcga gcgggccggg cgcgcggtgg agcgtgagat ccgccagaac ggcggcgaag
     7201 ccacctactt cagggccgac gtgcggcgcg cggaggacgt tcggtcattc gtgacacggg
     7261 cggtccgcac ctacggcggc ccggacatcg ccctcaacaa cgccgggata cagctgccgt
     7321 tcaccgacct gcacgaggtg tcggtcgcgg agtgggacga ggtcgcgagc accaacatcc
     7381 gcggcgtgtt cctcgccatg aagtaccaga tcccgttcat gagggaggcg ggcggcgggg
     7441 tcatcctcgt caccggctcc tccaaccagt tcgccaccag gaccggcctc gcctcctaca
     7501 cggcggccaa gaacggcgtg accggactcg tccaggccgc cgccctggag aacgccgccc
     7561 acggcatccg ggtcgtcgcc atctcccccg gcatgaccga caccgagatg ctcgacgccc
     7621 accgccccgc aggcatctcg gacgaggaat ggcgggccac gaaggccgcc ttcgccgaac
     7681 agggcgtcga cgcgatgaag cggatggccg agcccgagga gatcgccgcc gccgcgctcg
     7741 ccctggcctc cgacgccttc tccttccaga ccggcacctc gataccggtc gacggcggcc
     7801 aactcgccgc cctctagcga ccgggcggcg cggctgtccc acgaacggca aggcacgcgt
     7861 gtcacttcgc gggctgcggg ccgcgccgcg gttcggtgag ggcggcgcgg accagggacg
     7921 agacgcggta accgcctccg cccccggggt ccgcgcacag cagcccgtgt tccgtcaggc
     7981 cgtcgagagc cgcctccgcc tccgcgaccg tgaccgcggc caggcccgcc gcgtccgccg
     8041 cggtcagccg gtggcggccg tgccgggcca ggcgccgcag ccacagccgc tggcttttcg
     8101 tgcacctggc gatggcggcc tcggccaagg ggcgcatcgc gaggccgtcc acctggagtt
     8161 cgttcagcag gtgcctgggg tcggcgagcc gaccggccag ccgggacagc ggccgggtgg
     8221 ggcacagcgc gagtttgacg gcggcgatgt gcagggccag cggatgaccg tcgcaggcca
     8281 cggcgatcgc ctcggccgcc tccggttccg cgtcgacgcg ttcggcgccc acgcagtccc
     8341 ggaggaaccg gatcgcggac gaccggccga ggccgctcaa tctgaccagg gagtgggccc
     8401 gcagggcggc gagcgggcgc ctggacgtga ccaggaccgt gcgggcggac ccggcggcca
     8461 gggccgcacg gccgacctcc gggtcccgca ccccgtcgag caggagcagg tcgggacgtt
     8521 cccccagccc gtcgacccgc tgccacgcct caccgggtga cgtgcactgg tgcaggtcga
     8581 cgtaggcgac ggtgccgccg ttcgctcccg accaagcgcc ccggcgatgg gcggcgtgca
     8641 gggccagcgc cgacttgccg ataccggggg gcccgcagat gaccgtcacc cggtgctccc
     8701 gcccctccgc ccgcgccgac gtgctgtcca gcacccgccg gagtgccccg tcccgcccga
     8761 tgagcggagt caccggtggg ggcgcggccg aggatgtggg cgccgagaag tgcgcgccgt
     8821 cgagtgccgc gctccgcagg ccccgcgccg gcaccgcgcc gtgctcggcg gccagacgcg
     8881 cggcgaaggt ccggtacgcc tcggccgcct ccggatcacg cccgtcgctg cgcagggcac
     8941 ggatcagctc ctcggcgacc tgctcgtcgg tggggaacga gaccgcgaga ccgcgcaggt
     9001 ccgtcacggc gtcggcggcc ctgcccgagg cgagccggat cgcggcgcgc gccaggaccg
     9061 ccgcgcggta gtggcactcc agctcggccg tcgtctcgtg cagcagaacg tcgggggcca
     9121 cgccggtgta gggccgtccc cgccacagtg agacggcctc gtcgagcagc gactccgcca
     9181 tccgcagccg gccgtctccg cgagcccgca gccctcggcg gagcaggtcg cgcagccggc
     9241 tcgcgtccag cgcctccggc gtgacgggaa ggaggtagcc gcccgcgcgg gtctcgatga
     9301 cctgcccggg ggcgtagcgg tcgaacgtct tccgcaggcc gtggatgtag gtgcggaccg
     9361 tggtcgcggc cccgcggggc gggctgccgc cccacaggcc gtcggccagg gtctcggtgg
     9421 cgacgaacgt gttgggccgc accgtcagca gggccgcggt gtcccgcagt cggccgctga
     9481 gcggcagctc catgccctcg ctgctgagca gttcgacggg accgaggaca cggaaggcca
     9541 ccgcgcctcc ggaacgtccg ctcgcactca ctccgaccgc cacctctcca cccgtgtcca
     9601 cccgcgtaga ccgctgttgc cacccccctg gccggttgac taccccgacg cgccgaccgg
     9661 tgcgttgagt gcgcgtttac cgaacgtccc ggacccggcc gcgcgccaac aaatcacgtc
     9721 acctggcgtg acgaggtgat cgcgcgccgg accgctccag ccggacaccg cggcccgtat
     9781 cgccgtgaaa cgccaccgcg cggcgcgggc ggtgttgcgg cgaccgccct gccaggccgg
     9841 ccgcccaaca cgtcgccaac acggcgccaa caccgcgttt ctaggctccc tgagcgaatc
     9901 ggtgttcagg gccgggacgc cccgccgcac cgactcgcca gcccgggcgg cctccgcccg
     9961 gccatcgacc aagcaccgac cgacgcggcc gggaggctcc atgaccagtc accatcacga
    10021 agcggccggg cacggcgacg agcacgatta cgtggacgac ttcctcgcgg tccgcgacgc
    10081 cgtggccccc ctgcgcggct ggcggcacct gccggaggag atgtggtgct acgtcacccc
    10141 gccggactcg gagttccgcg cgcagggctg gaagatccac gtctcggcca cgccgcgctc
    10201 cgcggtgccc gtgctccggg ccgcgtcccg cgtgctgctg gagcacaagg ccgccttcaa
    10261 gttcgccaag agcctgagcc ggctgcggat gctgctgtcg atccggatgg accggggcgc
    10321 cggcggcaag ttcatcaccg tctacccctc atccgacgag cagttcaccg acctgctcca
    10381 ggccctgcac cgggcgaccg agggacttga ggggccggcc atcctctccg atcgccggta
    10441 cctccccgac agcctggtgc actaccggta cggcggcttc agcgcgggtc agcaggtgct
    10501 cgacgtggac ggggcctacg tcccgatgct ggtcgcaccg gacggctcgt ggagcaagga
    10561 cgagcgcacc gcctggttct ccccgccacc gtgggcctcc gccccccggc tgcccgaggg
    10621 ggtggagcag cccgggccgg tgaggcggca gcggagcaag ggtcaggtgc tgctcaacga
    10681 ccggttcgtg gtcttcgagg cgatccgcca ctccaaccgc ggcggcgtct accgcgcgct
    10741 cgaccggcac gacggcgacc ggcgggtgat catcaaggag gccaggccgt tcgtcgccgc
    10801 cgagacctgc ggcacggacg ccagggacta cctgcgcaac gagtaccgca cgctgagcct
    10861 gctcgaaccg ctcggcatcg cggtcaagcc ggtcgacctc ttcgagtacc aggggcactc
    10921 cttcatggcg gaggaggagg tgccgggcgt tccgctgcgc gactgggtgg ccgaacgcat
    10981 caggaacgag ccgtcgcggg cgctcccgct cgacgcggtg ctgcccgtgg cccggcgggt
    11041 cgtcgcgctc gccggagcgg cgcacgacaa ggggctcgtc ctgcgcgact tcacgcccaa
    11101 caacatcatg gtcacccctg gcggtgaact ggtgctgatc gacaccgagt tcgccgcgat
    11161 tccgggtgag acgaccaccc gcatccagac cccgtcctac acggcgcccg aggagatcgg
    11221 cggcccgacc cgctatcccg cgccttccca cgaggcggac ctctacagcg tcggcgcgac
    11281 cctgttctac ctgtgcacgg gggtcaaccc ggtcgtcgcc aacgacggct tcgcggcgga
    11341 accgggccgg aagccgccgg tgcgccccca cgacgagcgg gtcgagcgca tggtggccgg
    11401 ggtcgccgcg gacgttccgt cgctcgcggc gctcgccccg gcggtgctcg gcctgatgcg
    11461 ggaggacccc acccggcgca ccggtctcgt ccaggtcctc gaccttctcg acacgccccg
    11521 ggtccccgtg cccgccgccg cgccgcaccg cctgtccgcg gccgaccgcg accgcctgct
    11581 cgccgacgga acggcgcagc tcgtcgccgc catgacgccg gaatcccgcc ggagcctgtg
    11641 gccggcgccg cccatggagg gccgccagtt cgacacgctc gccgtccagg ccggcagcgg
    11701 cgggaccctg gaggtcctgc ggcgcgccgc gctccgcgcc gagggcgccg agggcgggga
    11761 gcgcctcgcc ggcggcgagc tgaccgaggc gctgcgcacc gcgctgacgt ggctcgaccg
    11821 gcacgccgac gacgaacgcc gccagctccc cggcctctac ttcggccgtg cgggcaccta
    11881 ctgggccatg tacgaggccg ccgccgcact cggcgaggag gagatcgggc ggcgcagcgt
    11941 cgaccgcgcc aagcgcctgt ccgtgaactg gaccaacccg gacatgaccc acggcatggc
    12001 gggcaacggg ctcgcgcagc tgcggctgtg gcggcgcacc ggggacgagg agttccgcgt
    12061 tcgcgccgag ctgtgcgtgg aggcggtgct cggggcccgt tccgaggacg gcaccacgtg
    12121 gcctgtgccc gccgcgatgg gccaggtctc cgggctcacg cactacggct tcgcccacgg
    12181 ggtggccggc gtcggcgcgt tcctcgtggt cgccgcgcgc gaactcgggc ggcccgacct
    12241 gctcgacatc gcgacgtcca gcggcgacct cctgctgtcg ctggccaggc ggcagggcga
    12301 gtcgctggcc tggcccaccg cccagcacga gccggaggac gccgagaagt tcgacggtgt
    12361 ctgctggtgg tgcagcgggg ctcccggcat cgggacgttc ctgatccggc tgtggcgggc
    12421 caccggggag gaccgtttcc tcgaagccgc gcacggcgcc gcggtcgcca cccgcaggga
    12481 gaggtggctc ctgctcgcct cgcactgcca cggtgtcgcg ggcaacggcg agttcctgct
    12541 cgacatggcg gcggccacgg gtgaacggcg ctaccgggac tgggccgccg agcacgcggc
    12601 ctcgctgtac cggctgagcg ccctgcacga gggccgtctc gtggtcctgg acgagaccaa
    12661 ctcggccctg acctacagct acggggtggg catggcgggg gcgatcggct tcctgcaccg
    12721 ccaccgccac ggcggtgaac gctggtggat ggtggacgac ttcaccctgg agcccgaggg
    12781 ggagtcccgg tgacggccgt gaccgccgcc gcggcaacga gcgcgcccgg cacgggcgcc
    12841 gtgcccggag ccgcgcccgg ggccgccatg ccccggctgt ggccgctgct cacctcgctg
    12901 cgctcccggt tctccttccg gttctccacc acgggacgcg ccgccgccgc gctggtggcg
    12961 gacgggcgcg gagtcctgtt ctgcgagttc tgggacctgg cggacgaggc gggaacggcg
    13021 ccgacctgcc gcgttgtccc cggcttcagc agaccggcgc gcgcggagga cgacccggcc
    13081 tcgctgccga gcgacgcgct gcccttcgac gacggctcgg tcctcgtcgt cgccaggacg
    13141 ggactcgaac tggtcaccgc ggccggtgcg cggaccgccg ccgggcggct gccgttcagg
    13201 ccggtcgtga ccgcccccgc gcccggcggg cggccgggcg cgctgttcct ggggcgcgac
    13261 gacgcgggcg cctggtccgc ctggtggtgg gacccgtccg ccgccggggc gcggcgggtc
    13321 ggcggcgtgc cgccgctcac gctgcccagg ggcgggggct ggctggacga gggggcgacc
    13381 cgtttcgcgc tcaacgcccc ctcccccgcc ggtcccgggc ccacggcccc cgcggtcctc
    13441 acggtccccg agggccggct cgaaccactg cccgtcgggg acccgagcga gcacgacatg
    13501 gtctggcaca ccgtcccgcg caccggcgag tccctgctgg tcggcaccga cggctccgcc
    13561 cacgcgctgc ggctctcggg tcccggcggc acccggcggc tgaccgccgc ggacgcgctg
    13621 acgggttcgg tgaccccgct cgccctcgac gcctccggca ccctgctcgc cctccatgaa
    13681 cgcgtcgggc agcgcgaccg cctgaccgtt ctcgacaccg tgcgggacgc gcttctcgac
    13741 ctgccggagc ggggcgacac cctgtacgcc cacgccacgt ggaccgagac cggctcggga
    13801 acgcccgggc tcctggcgtt cgtggccgac gcggggcgcc ccgcccgcgt ggcgggcacg
    13861 gcaccgggag ccgagggctg gacccacgtc acggacggca ccgaggcggg cgaccacgac
    13921 gcctacgcgc ccgggcacct ggagcgactg ccgggagcgg ccggcgacat cgaggccgtc
    13981 gtctgcggtc accaggactg gcgcaccgcc cgcggggtgg tgctctgcct gcacggcggg
    14041 ccggccgacc actgggcgct gaagttctcc ctgctgttcc agttcctcgc cgacctgggc
    14101 ctgaccgtga tcgcgcccaa tccgcgcggc agcacgggtt acggcgacgc gttccaccgg
    14161 acggtcgtgg gcgcgtgggg cggccccgac ctcgacgacg tgctcgccat cgcccggcac
    14221 ctcagggccg aacgccggac gccggagggc ctggccctgt acggcgcgag ctacggcgcg
    14281 ttcctcgccc tgctggcggc ggccaccgag ccggagttgt ggtccagaac gctcgccgtc
    14341 gcccccatgc tcggcggccg gcgcctgcac ccggaggccg acgcgtcggt acgcgccctc
    14401 atcgaccggc tcgacgggca cgccgtcgtc gacgatcacc tcggcccgcg cgacccgctg
    14461 gcccgcctct cgcgcatcac cgccccgctc gccgtgatcc acggcgcgga cgacccgacc
    14521 atcccgccgg gtcagtcccg ccggctcgtg gcggaactca gacgtctcgg ccgccggccc
    14581 ggcaccgact tccaccacgt ggaggtgccg ggagccggcc acagcccgct cgacggctcg
    14641 gccgagctgc accacacggc ggccctgttc ctcgccgaag gcgtgtggac ggggccggcc
    14701 accacctgac cgctccggcg acgctcgcgc ccggagtccg caccagtggg aggagaggag
    14761 gtgaaccaca tgacgatcgc catcgaggcc ctccaggagc tggaggagac cgagagcggc
    14821 ctggccgact gccccatcgg ctcgtgctgc ggagcgtggc tgcccgtgcc cacggccttc
    14881 acctgcttcg gcaacacgtt cggaagctga cggggcgcgg cgcgccacgt cacaccacga
    14941 cgacgtaggg aaggaggtga accgcatgtc cctcgccatc gaggagctcc aggaactgga
    15001 ggccacggag gaggcggccc tggccgcgaa caactgctgc tggaactcga tcatcaacgg
    15061 ctgccagtgg cagagctttg ccatcctgtc gacctgccac ggctgcacca actcgaactg
    15121 accctccggg tcgcacggct tggaagccga agcgcgtgcc tccgaggagg tgaaatgacc
    15181 acgctgattc tcgaccttca ggaactcgag gccaccgaga acccggcctt cgacgaggtg
    15241 cagggatgtt gcgggctggg aacgctcctg acctgcccca cccgcacctt cgactggtag
    15301 gcggcagtcc gccctcctgc cgccgccccg tccggctcgc atccgggcgg ggcggcccgc
    15361 acccggcgcc ccgacgcgag gagtagtgcc cgtgccgacc gcttccccgg cgcagcccgc
    15421 gccgcccacg cgggccgcgc cgtcaggaga ccggctgctg gcccggctcc tgcgcggcac
    15481 ccgtgccctg accgccctgt acctggtcgc cgccgccgcc tcggccgcca ccgcgctgct
    15541 gctgcccgcc gccctggccg ccgccgtcaa cgccgccgtc gggcggacct cggccaccac
    15601 ccccgtggtc ctcacggtcc tgctgctcgc gatcgccgcg ctggccgagg tcgccgccga
    15661 gctggcgcag gtgaggacct cgacccgggg cgccgcctgg ctgcggcacg acctgctgcg
    15721 ccacatggtc cgcctcgacc tgcgcgggca acgccgtttc cccgccggtg acgtgctgag
    15781 caggctgctc cagagcacct cgcagaccgc gaacctggtg cccaccgtcg tcggcgggct
    15841 gatgtcgggc ctggtgtccg tcggcgccat cgcggcgctg ttcctcatcg accccggctc
    15901 cggcctgatc ttcctgctcg gggcgcccgt cgtctggctg gtcgcgaagg gcttcttcca
    15961 ccggaccacc gcgctcaccg agggctacca gcgcgcccac ggcgaactcg ccgggcgttt
    16021 cctcgaagcc gtccgcggca tccgcaccat cagggcggcc ggcaccgccg accgggagac
    16081 cgagcgggtg ctcgaacccc tcccccggct gcgcctgcac ggtgaacgct tctggctggc
    16141 ccagcgcgac gcgggctggc gcatctccct ggtcgtgccc gtgctccaga tcggtgtcct
    16201 ggccaccgcg ggacacgggg tggcctccgg tcgcctcgcc cccggcgacc tgctcgccgt
    16261 caccggctac ctcggccagg cgttcggcgt cttcgcccag atcggcgtga tcgcgagcct
    16321 cggccaggtc cgcggctcgg ccaaccggat cagggaggtg ctggccgcgc cccccgcccc
    16381 ctcggggagc cgcgcgttcc cgccgggcgg cggcgccctg cggctgtccg gcgtccgggt
    16441 cctggcggac gggaagcccc tcctcgacgg cgtggacgcc gaactgccag cgggcagcga
    16501 ggtggccgtg gtcggcgagt ccggcacggg caagtcgacc ctcgccgccc tcgcgggcgg
    16561 gctgctccac cccgacgccg ggaccgtcac cctggacggc gtcgacctcg cggcggccga
    16621 cccggccgcg ctgcgccggg agatcgcctg cgccttcgaa cgtcccgtgc tgctcggcgc
    16681 caccgtccgc gacgccatcg gctacggcga cgagcccgtg gacggcaccg cactcgcccg
    16741 gggcctgcgg gacagcggcg cgcgggagtt cgtcagcaag ctcccccggc agctcgacac
    16801 cccgctcggc gacctgcgcg cctcgggagg cgagtaccaa cgcctgggcc tggcccgcgc
    16861 gttctgccgg aacgccaggc tgctcgtgct cgacgacgcc acgtcgagcg tcgacgtcat
    16921 cacggaacgg cgcatcgccc gcgcgctgcg gaaccacccg gccacccggc tcgtggtgac
    16981 gcaccgcgtc tccaccgccg cccgcgccga cctggtcctg tggctccacg agggctcggt
    17041 cgccgccgtc gggccgcaca gcgaactgct cgccctgccc ggctacgcgg ccctgttcgg
    17101 cgaggccgtg ggctccgcgg gccaggcgcg ggagaccacg ggggcgcggc catgagcgaa
    17161 cggacgaccc gcagggcggg cacgcgcgcc gggctggcgc tgatccgccc cgcgctgcgc
    17221 gccgaacgcc gttcgatcgc cgcgctggcg ctgtggtcgg tcgtcgaggc cgccccgaca
    17281 ctgctgtccg gctggatcat cgggcgcgcg gtggacgact tcctcgcggg ggaggtgacc
    17341 gccgcgctgg tactgctcgc ggtgtacggc gtggcgatgc tggcggcggc cgtgagcacc
    17401 cgccaggtga tgggcccgct cgcccggatc gtggaggccg tgcgcgaccg gctggtcggt
    17461 accgtggtcg agtccgcgct gctcagtgcc gtgcgccacg gcacgacgcc ggacgcgggc
    17521 acggtggccc gcaccacgcg gcagacggag tcggtgcgcg gcctgatggc cgggctgctg
    17581 atgagcgccc gcggggtcgc gttctccgtc cccgccgtgg tcgtgggcct gttcaccatc
    17641 gcccccgtga tcgccgcgct gacgctggcc tcactggccg tgtcctgcgc gctgctcgtg
    17701 ctggtctccc gggtgctgcg gcgccggctc gtggtgtcct tgacggccga ggaggaactg
    17761 gccgagaacg cgggacgcct gcttgacggg ctgcgcgacg tggccgcgtg cggcgccccg
    17821 cgccgggccg ccggggagac cgggcgggcc gtcgaggcgc aggccgccgc ctcgatggcg
    17881 accgcgtggg cggaggcggg acgcatcggg gtgatcgtga ccggcgcccg tttgccgctc
    17941 gtcgggacgc tgctgctggc ccccgggctg atcagctcgg gccacctcac gccgggggag
    18001 gtcgtggggg tggccaccta cctggtcaca gggctcgaac cggcggtgcg caccatcgtg
    18061 cagaacctcg cggggctcgg gctccacctc ggggtcgtcc tgcggcggct ggccgagcgg
    18121 accgcgctcc ccgcgtcccc ggcgacggcc tcggccgccc cgcccgcagg tccggccgaa
    18181 ctcacgctgc acggcgttac gttcgcctac gggccgcact cggcgcccgt tctcgacaac
    18241 ctcgacctcc gcataccggt cggcgaccac ctggcggtgg tcggcccgag cggtgcgggc
    18301 aagtccacct tctcctcgct gctgtgcggg ctgctgccgc cggacgcggg agaggtgcgc
    18361 ctcgggggcc ggccgctgtc cggcatcgac ccgcgccgac tgcgcgaggc cgtcgtgctg
    18421 gtcccgcagg agtcctacgt cttcaccgga acggtccgcg agaacctcgg ctacctgtgc
    18481 ccgaccgaac ccgacgacgg accgctcaac gaggcgatcg acctgttcgc cctgcgggcc
    18541 gcagttgaac ggctcggcgg ccccgacgcg gtgatcgacg agccaggtgc gctctccgag
    18601 ggcgagcgtc agctcatcgt gctggcccgg gcctacctcg cgcccgcggg gaccgtcgtc
    18661 ctcgacgagg cgacctgtca cctcgatccg gtgcgtgagg cgcgggccga ggaggcgttc
    18721 atggcccgcc ccgggacgac cctcgtggtc atcgcccacc gcaccagttc cgcccgcagg
    18781 gccaagcgtg tcctggtgct cgaatcgggg acggcggtcg tcggggcgcg cggggccctg
    18841 gccggcgtct cgccgctcct cgacgacctg atgcggtgac ggcgcgcgcc accccccgcg
    18901 gcggaacgtg cgccgaggcc cggtcaggcg cgcaggagcc gcacgtgcag atcggacagc
    18961 tcggggcccg gctcgatacc gtgctgctcg cgcagcaccg atctgatctg ccgatagcag
    19021 ctcaacgcct cggcccggcg gccggtgagc cacagggcgc gcatgagctg cgcccagcgg
    19081 tgctcgcgca ggcagccgtc gcctaccagg gagcgcagct cgggcacaac ggccgccgcg
    19141 tccctggcca gctcggactc gatgagccgg tcgcgggcga cctccctggc ctccgtcaag
    19201 gaggcgcgga ccggcgccag catccccgtg gcgggcacgt cggccagcac ctctccgcgc
    19261 cacagcgcca gcgcgccgcg cagctgtgcg cgcgccgcgt tctgctcgcc gtgctccagt
    19321 ctctcccccg cgcgctccag cgccgcgccg aaggcatccg cgtcggtgtc ggcggcgccc
    19381 ggtggggcga tcaggcggta gccgcacgac tggcgctcga tcaccggccc gtcctcgtca
    19441 ccgaggaggc ggcgcagccg catcacgtag ttgcggatca gggcgggcgc tgtctcgggc
    19501 ggctggttcg gccacagttc cccgacgagc tcggtgacgg ggagcgcggt gtcgcgccgg
    19561 acgaccagaa cggccagcag gtgccgctgc ttggccgcgc tgaccggctg ccaccgctgg
    19621 ccgcatcgga cccgaagcgg accgaggatc tgaaaacgca tgggtgccgg tccctcccgt
    19681 cgcggcgatg atcgttcgtc ggacactgtg cgccccggcg cgtagcagcc gcgtagcgcc
    19741 tgcgtggacc accgcgcccg aggggtcgtc cgcgccgtgc ggaccgagag gccggtcatt
    19801 ccgccctcgc tccgcgccag ttgatggcga acgagtcttt gagccgactt ccgggccgga
    19861 gttatcgtga cgcgcggccg gcgcagccac gccggcttcc tgtgctcgga ggctgttgac
    19921 gtggacatcc gattgctcgg cccggtggaa ctgcaccggg aggaccggcc ggtcgtcgtc
    19981 ggggcaccga tgctgcgcac gctgctggcc gtgttcgccg tgcggcccgg gcagctgcgc
    20041 agcgccgcga gcctgtgcga ccagctgtgg ggcacgacac cgccttcctc gcgtgccacg
    20101 ttgcggacgt acgtgatgcg cctgcggagg ctgctgcccg acggccgcct gcggagggtc
    20161 ccctcgggcg gctacgtgct ggacgcggcc ccggaggaga ccgacctcgg ccgcttccgg
    20221 acgcgactcg cccttgcgcg cggcctcgcc gagacacggc ccgacgaggc gttgcgcgcc
    20281 tacgaggccg cgtgcctgct gtggcgcggg gagccgctgg cggggctcgg tgacggcccg
    20341 ttcgccgccg ccgaggctcc ccgtctcgct gcgctgcggc tcgacgccca ggaggagcgc
    20401 ttcgccgttc acctgaggct cggccggcac gcggagatcc tggacgagct ggccgccgag
    20461 gcccgggcgc accacctcag ggaagggctg acgcgccacc tcatgctggc cctgcaccgc
    20521 tccggccgca catcggaggc gctggacgcc taccgatcgc tgcgccggcg actggtcgag
    20581 gatctcggca tcgagccggg gcacgagctg cgggcggttg agcaggcgat ccttcgcgcg
    20641 gacccggcgc tgctgctccc tggtcccggc gcaccgccga acctggccgc gggcccgcgt
    20701 tccaaggccg ccgccccggc gctcccgggg gccatcgccc cggcgttccc cgcggccgtc
    20761 ggcacgttcg tggcccgtgc gggggagttg gcactgctgg gtgagtggct ggacccggcg
    20821 gcgacggcgc ccggggtctg cctgctggac gggcccggcg gggtgggcaa gtcggccctg
    20881 gcggtcctgg ccgcgcggaa gtcggcggcg cggtttcccg acgggttgct ccacgtggac
    20941 ctgcgtgggg ccgacccgga cgacgcaccg ctcgacgtcg ctgtcgccgc acagctgctg
    21001 ctctcgcaac tgggcgtgcc gatgcgggaa gttccccagg aggcggaaga ggccgccgcc
    21061 cgcttccgcg tgcgcctgcg cgggcgccgt tgcctcgtgc tcctcgacaa tgccagggac
    21121 gccgcccagg tgcgcccgct gctgccggac gacgcgcccg ccgtcgtgct ggtcaccagc
    21181 aggatggcgc tgaccggcct cgccggcgga cgccacctcc acctcgggct gctcgaccgc
    21241 gcggactcgg tcaggctgct gcggaccatc gcgggaccgc gcacggtgtg cgccactccg
    21301 gcgcaatggg ccgaactggc aggactgtgc ggagacctgc cgctcgcgct gcggatcgtc
    21361 gccgcccgga tggcggccag gccgggttgg gaggtggccg agtggatcgc gctgctgcgc
    21421 gacgaacgcg ggcgcatgga ccagttgcgc accgccgacc tggacctgcg ggccggtctg
    21481 atggtcggca tcgaccgcct cgccgggagc gaggacccgg ccgaccggca ggcggcggcc
    21541 ctcttcccgc tgctcggcgt cccggcgctg cacacctacc ggcccgcctc ggccgcggcg
    21601 ctggccggct gcacccccgc cgaggccgag gactcacttg aacgcctgac cgacgcgcgg
    21661 atcgcggaca gcccgcgcag cggggtctac gtactccacg atctgctgcg tgcggcggcc
    21721 aggtggcagg ctgaccgcct gccgcccgag cacgccaggg agcggctcgg cgcgctggcc
    21781 cgctggtacc ttggcaccct tcaccgggcg ggcacgcggc tgagttcggc cggctggctc
    21841 aggtcccggg tgcgtcaggg catcgcccgg ttccccgacg gcgacgactt ccccgactcc
    21901 gagtcggcgc tggcctgggc cgacacggcg gtgccccagg cgctgacgct cgcggagcag
    21961 tgcgcggcac cggagtaccg ggatgggacc gagctggccg gccgcccgct gagcaccttc
    22021 ggcctctcgg ccgcacgtgc cctgaccggc tacttcgcgt tgcggatgaa cctgcgcgac
    22081 cagcggcggc tggccacgct ggtgctgcgc accgccgaac gggacggcga cgcgttcgcc
    22141 cgcggcttcg cgctcggtca gctcggaaag gtactcggcc agagcggcga cgtggagggc
    22201 gggctgccgt tgctctccga gtcctgggac gtgctcacca ggatgggcga ggtgcgcgag
    22261 gcgatcgcgt ccgcctccaa cctggtgggc tgcctggggc aggccaggag gccggaggag
    22321 gcgatacgcg ccggtaggcg ggccctggcc gcggcggagt cggccgatct ggtggaggcc
    22381 agaatcacca tcgggaccaa tatggggcac gcgcactacc tggcgggcga cctggtgagc
    22441 gcccggcggg tactgatcga ggtgtgcagt gcggcgccgg agccgaccgc ggtgctttcc
    22501 tccacgctgg ccagcctggc ggcgtgcgaa ctcgcggccg gggaccacgc ggaggcggcg
    22561 cgctgggcgc ggaccggcct cgcgctcgtg gaaaggcacc cggtcgaccc gctgtcgcgg
    22621 gcggagttgc acagcctgct ggccagcgcg ctcagagtgt cgggggacga acgggccgcg
    22681 cgggcggaaa gcgccgtcgc tctgcgtctc gtggacgagc tgaacgcccg ggaaaacctg
    22741 cacctgcgca tcccggaccc gggaccggcc tagccgaaac gcgtcggaag gcc
//
