LOCUS       NZ_CP084541            10408 bp    DNA     linear   CON 20-NOV-2024
DEFINITION  Streptomyces marincola strain SCSIO 64649 chromosome, complete
            genome.
ACCESSION   NZ_CP084541
VERSION     NZ_CP084541.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces marincola
  ORGANISM  Streptomyces marincola
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 6629020)
  AUTHORS   Shi,S.
  TITLE     Strepomyces indimicinicus sp. nov., an antibiotic producing
            actinomycetes isolated from the marine environment
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6629020)
  AUTHORS   Shi,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2021) Key Laboratory of Tropical Marine
            Bio-resources and Ecology, South China Sea Institute of Oceanology,
            Chinese Academy of Sciences, 164 Xingang West Road, guangzhou,
            Guangdong 510301, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. V6.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 444.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_020410765.1-RS_2024_11_18
            Annotation Date                   :: 11/18/2024 03:45:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,763
            CDSs (total)                      :: 5,689
            Genes (coding)                    :: 5,612
            CDSs (with protein)               :: 5,612
            Genes (RNA)                       :: 74
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 77
            CDSs (without protein)            :: 77
            Pseudo Genes (ambiguous residues) :: 0 of 77
            Pseudo Genes (frameshifted)       :: 21 of 77
            Pseudo Genes (incomplete)         :: 60 of 77
            Pseudo Genes (internal stop)      :: 2 of 77
            Pseudo Genes (multiple problems)  :: 6 of 77
            CRISPR Arrays                     :: 10
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:57:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1634725
            Orig. end                         :: 1645133
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP084541.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10408
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="12"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10408
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10408
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5408](+)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5408
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     gene            27..2558
                     /locus_tag="LC193_RS06985"
                     /old_locus_tag="LC193_06985"
     CDS             27..2558
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138: FAD linked oxidase domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015649.5"
                     /locus_tag="LC193_RS06985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_06985"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_226072600.1"
                     /transl_table=11
                     /translation="MVQQFSFRILGPLIAHGTGGQIKLSGDRQRILLTMLLIDANRIIE
                     ADRLLRAIWDDAPPATARSQLRICVSSLRRQFTGGGVAATIETHKSGYEIKVAESEVDL
                     HVFLSLVARARAAADAGPSEETVRAFQHALGLWRGPIGAGLDSALLETVALKFHEDRYA
                     ALEDRFELELQLGRHRRILGDLTHHVAENPFRETLAAQLMIALFRSGRTAEALSLYRQT
                     RRRFSDELGIEPGERLRTIEQRILGGEVDCDLSSRPVGAVPGHGAGQRPEAGPARQPHG
                     AGAPAAQDRIASLEAEIAVLREAYTRLADGAGGRRPSPFAASGLHALVPAPWRPVRLSP
                     SVEGEGAGHLPRLRGVGPGARPQQTPDQRRTRVTRGSSGPGRKERTMAEQPQAPAASRE
                     TLDRLITQVRGEVFTPGDAEYEAELSGFNLIARHRPDVVVQAVTEADVQAAVRFAAALD
                     LPVGVQATGHGIAAPADGGVLISTRRMNAVRVDARNRTARVEAGARWHQVIAAAAKHGL
                     APLNGSSHLVGVVGYTLGGGLGPLGRQYGYAADHVVRIRLVTADGALRDVTAEQHGDLF
                     WGLRGGKGSLGVVTAMEFGLMPVARLYGGGIYFPGDLSGPLLRTWRRWTAGVPEAMTSS
                     VALLRLPDLPAIPAFLRDRLVAHLRVAYTGSDAEGEELLRPLRAVGPALLDAVGPMPYT
                     AVADIHRDPTEPLPYHERNIVLRELDESAVAGLLALAGPESEGDDLVVELRHLGGALSR
                     PAAVPNAVGSRDGAFVLSTLSLPGSPDLVLRGMAPWGTGLRYLNFLAGPDTADAARECF
                     PEATRARLAALKAAYDPHDMFRLGHAIRRDG"
     misc_feature    471..473
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    1083..1085
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            2629..3999
                     /locus_tag="LC193_RS06990"
                     /old_locus_tag="LC193_06990"
     CDS             2629..3999
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515809.1"
                     /locus_tag="LC193_RS06990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_06990"
                     /product="MFS transporter"
                     /protein_id="WP_226072602.1"
                     /transl_table=11
                     /translation="MSTRETLPPTAAAPPGARPISPRSAGLRYGALFGPAVFGVTAAGV
                     ALPDVASALDATPSAVAWVLTAHALALGVGTALFGRLADSRGLRTSLLLGSLVLAVGAA
                     VCLLAPNLPVLVAGRFVLAAGSGAMTSVAVTLSASVAPADRPKVLAGFGATMAVFSASA
                     TLAGGVFTEWVTWRVALILPALSLLAVPLCLRPAAARAASGRPLDLPGAVLLTVAASSF
                     LLLIQASALDLSTALVVGLAVVLPASIAALVVRVRAVPASFVPRWLVTDSLFLRAAGTG
                     IGVYAGLFAAMYTVPQILVDDHGLSVLAVGLWLLPGAVVGAVLSRLAGRLPVTSGGPVL
                     IAAIALVMAVTLAVSLGSENAVLPVVGASLGFAAFAATQVVSTGLMGAHVEPALRGGAT
                     GLLNLAFFVGGGVGSATAGALAKSASLYTTLGIVAGFPLIAAALALTLTRRGARAGG"
     gene            4289..4498
                     /locus_tag="LC193_RS06995"
                     /old_locus_tag="LC193_06995"
     CDS             4289..4498
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="LC193_RS06995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="LC193_06995"
                     /product="hypothetical protein"
                     /protein_id="WP_226072604.1"
                     /transl_table=11
                     /translation="MPHPAARPGRTALFVGPGADVRGTVAPSGRVNGDDGDDTLMLAVN
                     NGVVCGGPGMDACVVASGTPAVNR"
     gene            5001..5408
                     /locus_tag="LC193_RS07000"
                     /old_locus_tag="LC193_07000"
     CDS             5001..5408
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012380458.1"
                     /locus_tag="LC193_RS07000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_07000"
                     /product="tyrosinase cofactor"
                     /protein_id="WP_226072606.1"
                     /sec_met_domain="melC (E-value: 7.6e-30, bitscore: 102.2,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLNRREMVAGVAGTALVAAAAATPLVTGSGGGADAHAAHGGEGG
                     AGAGDAGEYVETYQGRTIRVLPEAAGGGVLIDDRPLHLMKFGDDAYLSSMCHYEMAPSP
                     LHAARRAVEELRGAALLPAAHGSHGTHVTVV"
     gene            5469..6389
                     /gene="griF"
                     /locus_tag="LC193_RS07005"
                     /old_locus_tag="LC193_07005"
     CDS             5469..6389
                     /EC_number="1.10.3.15"
                     /codon_start=1
                     /gene="griF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515805.1"
                     /locus_tag="LC193_RS07005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_07005"
                     /product="grixazone synthase"
                     /protein_id="WP_226072607.1"
                     /transl_table=11
                     /translation="MVHIRKNHLDMTREEKRRFVHAVREIKRRGIYDRFVDLHIRINSR
                     DYLDKETGKRLGHINPGFLPWHRQYLMRFERELQRVDPRVTLPYWDWTVDHGEDSPLWD
                     EEFMGGNGRPGDRRVMTGPFARDNGWVLNISVVPVGEENPALNGNYTHDDRDFLVRDMA
                     TLTDSLPSPQELEDTLALPVYDCPPWNHTSGGEPPYESFRNHLEGYTKFPWETKFGKLH
                     GAGHLWVGGHMMYIGSPNDPVFFLNHCMIDRCWALWQQRHPDVPHYLPLHDTPDVPDLH
                     TPLGPWHTLTPADLIDHTRWYRYDS"
     misc_feature    6423..6437
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: strong, score: 27.49"
                     /tool="antismash"
     gene            6525..7499
                     /locus_tag="LC193_RS07010"
                     /old_locus_tag="LC193_07010"
     CDS             6525..7499
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018840847.1"
                     /locus_tag="LC193_RS07010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_07010"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_226072608.1"
                     /transl_table=11
                     /translation="MPFARRARAVAAQAAVTAFLLSVTAACGPGGGGDGSGPDDLDLGV
                     IPIIDVAPVRLGVEQGFFAEQGLDLTMTESQGGAAIVPAVTSGSLQIGYSNIVSLLVAR
                     SQGVPVRMVSVGARASADALDDGSGQLMAADEGITDVADLRGRTVAVNTLLGINEVAVR
                     TGLERHGLSADDVSLVELPIPNMPAALAAGDVDAAMLSEPFTTIAEADGAHAVPVSYAA
                     MGEGLPIAGWFTSESFAREHPDVLERFTTALERSLRYAEEHPDEARAVLDSYLDLADGV
                     SAEVTLPGWDPATEPAEIEDVARLTAEAGLIEDLGPLDGLIAP"
     gene            7543..8343
                     /locus_tag="LC193_RS07015"
                     /old_locus_tag="LC193_07015"
     CDS             7543..8343
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018844655.1"
                     /locus_tag="LC193_RS07015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_07015"
                     /product="ABC transporter permease"
                     /protein_id="WP_226072609.1"
                     /transl_table=11
                     /translation="MAWYQHRRTRAVPESLLGPAGLLLAAALVEVLPRAGLVPAEYLPP
                     LSAMAGALAGEAGDAAFWRALRDTLTGWGAGLALATAAGVLLGLVIGRAEPLRRATAST
                     IEFLRPIPSVALVPLAVLLHGTGPRATLLLVVYAAVWPVLLQVLAGVRDVDPVARDTAA
                     VFRLPTLTRLRHLLWPTLLPYLMTGLRLAASVALILAVTAQLVIGSPGLGREIALAQAA
                     NAVERMYALVIVTGLLGVCVNAGARALERRVLFWHTSERTEAAA"
     gene            8340..9293
                     /locus_tag="LC193_RS07020"
                     /old_locus_tag="LC193_07020"
     CDS             8340..9293
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019521886.1"
                     /locus_tag="LC193_RS07020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_07020"
                     /product="ABC transporter permease"
                     /protein_id="WP_226072610.1"
                     /transl_table=11
                     /translation="MSRNAPVRTRERGRSRVRGGARTALRAAASGAVRLAYALGLPAAL
                     LALWWALTARGGSFYYPPLGDIAAAFTDTWLTGGRLARDVAPSLARLAAGWAGAVLLGV
                     GLGLLLGLRPRLRALAEPLLAFCRAVPPPVLIPVLMLVAGIGNGMKVAVIVTGAVWPVL
                     LNTIQGVRSLDEVLSDTARCYGVTGAARLRRLVLPAAAPAIVTGMRQALSLAIILMVIG
                     EMFASSSGLGFAIVQFQRGFAIPEMWSGIFLLGLVGFGLSLLFGLFEARALGWYHGQRG
                     LARGAGGARRAARPRERAGGDTRAGDAGTASARDEE"
     gene            9295..10137
                     /locus_tag="LC193_RS07025"
                     /old_locus_tag="LC193_07025"
     CDS             9295..10137
                     /EC_number="7.6.2.14"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018840850.1"
                     /locus_tag="LC193_RS07025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_07025"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_226072611.1"
                     /transl_table=11
                     /translation="MTTRTPGARAADAVAPGRLDVVGLAKTYRDRRRTVEAVRDLTFTV
                     EAGRLACVVGPSGAGKTTLLRCVAGLLAPTSGTVRIGGEPVQAPPPGMAVVFQEYARSL
                     LPWLTVARNVELPLRHKKLPRAERERLVARSLAAVGLADASAAHPWQLSGGMQQRVAIA
                     RALAYEPDVLLMDEPFAAVDAQTRADLEDLTRALWRERGMTVLFVTHDIDEAVYLGERV
                     LVLSAAPTVVLRVIEIDLPEEREQLATRALPRFAELRAEVFGLVRQAKTYHDAPGART"
ORIGIN
        1 attcatgctc gacccgaggg gacttcatgg ttcagcagtt ctccttccgg attctcggtc
       61 cgctcatcgc gcacggcacg ggcggacaga taaaattgag cggcgaccgg cagcgaatac
      121 tgctgacgat gctgctgatc gacgccaacc gcatcatcga ggcggaccgc ctgctgcgtg
      181 cgatctggga cgatgcgccg cccgcgaccg cgcgcagcca gctgcggatc tgcgtgtcct
      241 cgttgcggag gcaattcacc ggaggtggcg tcgccgccac catagaaacg cacaagtccg
      301 gctatgagat caaggtcgcg gaaagcgagg tggacctgca tgtgttcctg tccctggtcg
      361 cccgggcgcg cgcggcggcc gacgccggcc cgagtgagga gacggtgcgc gccttccagc
      421 acgcgctggg tctgtggcgc ggcccgatcg gcgccgggct cgacagtgcg ttactggaaa
      481 cggtggcgct gaagttccac gaggaccgct acgccgccct tgaggaccgc ttcgaactgg
      541 aactgcaact cggcaggcac cggcggatcc tgggggacct cacccaccac gtggcggaga
      601 acccgttccg cgagacgctg gcggcgcagc tgatgatcgc cctgttccgc tccggccgca
      661 ccgccgaggc cctgtcgctg taccggcaga cccgccggcg tttctccgac gagctgggca
      721 tcgagccggg cgagcggctg cgcaccatag aacagcgcat actcggcggc gaggtggact
      781 gcgacctgtc gtcccggccg gtgggcgccg tgccggggca cggcgccggg cagcggcctg
      841 aggccgggcc cgcgcggcag ccgcacggcg ccggcgcccc ggccgcccag gaccggatcg
      901 cgtcgctcga agcggagatc gcggtcctgc gcgaggcgta cacgcggctc gccgacggcg
      961 ccggcggccg aagaccgtcg ccgttcgccg cctcggggct ccacgcgctc gtacccgctc
     1021 cctggcgccc ggtccgcctc tccccctcgg ttgaggggga gggggcgggc cacctacctc
     1081 gattacgggg ggtgggtcct ggcgcccgcc cgcagcagac tcctgaccag cgccggacgc
     1141 gtgtgacaag gggctcgtcc ggccccggca ggaaggaacg aacgatggcg gagcagcccc
     1201 aggcacccgc cgcgtcgcgc gagacgctcg accggctcat cactcaggtg cgcggcgagg
     1261 tcttcacccc gggcgacgcc gagtacgagg ccgagctgtc cggcttcaac ctcatcgccc
     1321 ggcacaggcc cgacgtggtg gtgcaggccg tgacggaggc cgacgtgcag gcggccgtgc
     1381 ggttcgcggc ggcgctcgac ctgcccgtcg gagtgcaggc gaccgggcac ggcatcgccg
     1441 ccccggccga cggcggtgtg ctgatcagca cgcggcgcat gaacgcggtg cgtgtcgacg
     1501 cgcgtaaccg caccgcgcgg gtggaggccg gtgcgcgctg gcaccaggtc atcgccgccg
     1561 cggccaagca cgggctcgcg ccgctcaacg gctcgtcgca cctggtgggc gtcgtcgggt
     1621 acacgctggg cggcggcctc ggccccctgg gccgccagta cggctacgcg gccgaccacg
     1681 tcgtccgcat acgcctggtc accgccgacg gagcgctcag ggacgtcacc gctgagcagc
     1741 acggcgacct gttctgggga ctgcgcggcg gcaaggggag cctcggcgtc gtcaccgcca
     1801 tggagttcgg gctcatgccc gtcgcccggc tctacggcgg cggcatctac ttccccggcg
     1861 acctgtcggg gccgctgctg cgcacctggc gccgctggac ggccggcgtg cccgaggcca
     1921 tgacgtcgtc ggtggcgctg ctgcgactgc ccgacctgcc cgccataccc gcgttcctgc
     1981 gcgaccgcct cgtggcgcac ctgcgcgtcg cgtacaccgg ctcggacgcg gagggggagg
     2041 agctgctgcg cccgctgcgc gccgtggggc ccgcgctgct cgacgccgtc gggcccatgc
     2101 cctacacggc cgtcgccgac atacaccgcg acccgaccga gccgctgccg taccacgaac
     2161 gcaacatcgt cctgcgggag ttggacgaga gcgcggtggc gggcctgctg gcgctcgcgg
     2221 ggccggaatc cgagggggac gacctggtcg tggagctgcg ccacctcggc ggcgccctgt
     2281 cccgcccggc cgcggtgccc aacgccgtgg gcagccgcga cggcgcgttc gtcctctcca
     2341 cgctctccct gcccggctcc cccgacctgg tcctgcgcgg gatggcgccc tggggcaccg
     2401 gcctgaggta cctcaacttc ctcgcgggcc ccgacacggc cgacgccgcg cgcgaatgct
     2461 tccccgaggc cacccgcgcc cggctcgcgg ccctcaaggc cgcctacgac ccgcacgaca
     2521 tgttccgcct gggccacgcc atccgccgcg acggctgacc acgacgccgc acccctgccc
     2581 cccgtcgacg agccaccgga ggaccaaccg gtggcggaag gactacccgt gtccacacgt
     2641 gagaccctgc cccccaccgc cgccgccccg cccggcgcgc ggccgatcag cccccggtcg
     2701 gccgggctgc gctacggcgc gctgttcggc cccgccgtct tcggcgtcac cgccgccggc
     2761 gtcgccctgc ccgacgtggc cagcgccctg gacgccaccc cgtcggccgt cgcgtgggtg
     2821 ctgaccgcgc acgccctcgc gctcggggtc ggcaccgccc tgttcgggcg cctcgccgac
     2881 tcccgcggcc tgcgcacctc gctcctgctc ggctcgctgg tcctggcggt gggcgcggcg
     2941 gtgtgcctgc tcgcgccgaa cctcccggtg ctggtggccg gccgtttcgt cctggccgcc
     3001 gggtccggcg cgatgacctc ggtcgccgtc acgctctccg cgtccgtcgc ccccgcagac
     3061 cggccgaaag tgctcgccgg gttcggcgcc accatggcgg tcttctccgc gagcgcgacc
     3121 ctggcaggcg gcgtgttcac cgagtgggtg acctggcggg tcgccctgat cctgccggcg
     3181 ctctccctgc tcgccgtccc gctgtgcctg cggcccgccg cggcgcgcgc ggcctcgggc
     3241 cggccgctcg acctgccggg cgccgtcctg ctcacggtcg cggcctcctc gttcctgctg
     3301 ctcatccagg cgtccgcgct cgacctgtcg accgcgctcg tcgtggggct cgccgtcgtc
     3361 ctgccggcct cgatcgccgc gctggtcgtg cgggtgcgcg cggtgcccgc gtcgttcgtc
     3421 ccccggtggc tggtcaccga cagcctgttc ctgcgcgcgg cgggcaccgg catcggtgtg
     3481 tacgcggggc tgttcgccgc gatgtacacc gtgccgcaga tcctcgtcga cgaccacggg
     3541 ctgagcgtgc tcgccgtcgg cctgtggctg ctgccgggcg ccgtggtggg cgcggtgctc
     3601 tcccggctcg ccgggcggct gcccgtgacg agcggcggcc cggtgctgat cgccgccatc
     3661 gccctggtga tggccgtgac cctggccgtc tcgctcggtt ccgagaacgc cgtcctgccc
     3721 gtcgtcggcg cctcgctcgg cttcgcggcc ttcgccgcca cgcaggtggt gtccacgggg
     3781 ctgatgggcg cgcacgtcga acccgccctg cgcggcgggg cgacgggcct gctcaacctc
     3841 gcgttcttcg tcggcggcgg cgtgggcagc gccaccgcgg gcgccctggc gaagtcggcc
     3901 tccctgtaca ccacgctggg catcgtcgcg ggcttcccgc tgatcgccgc cgcgctcgcg
     3961 ctgaccctga cccggcgcgg cgcccgggcc ggcgggtagc acacccgcgg tctccggcgc
     4021 ggtcccgcgc ccccggcggc cggccgtcgg gggcgccggg cggcgccgga ggccgcggtg
     4081 cgccggccgc cccgcacgcc acgtcgcggg gcggccggcg caccgccgcg cgagccgccc
     4141 gacggtccgc gccgcgcgcg ccgggcaggc ccgccccggc gcgcttccgc acgcccgcac
     4201 gcccgcgcgc cctgaggcgt ccgcgtttcc tcgccccgcc tgtccggaca tccggtatca
     4261 gcccgaaccg tccgtgcgaa gaatcgcgat gccccacccc gccgcccgcc ccgggcgcac
     4321 cgccctgttc gtcggcccgg gcgccgacgt ccgcggcacc gtggccccga gcggccgggt
     4381 caacggcgac gacggcgacg acacgctcat gctcgccgtg aacaacggcg tcgtctgcgg
     4441 cggccccggc atggacgcgt gcgtggtggc gagcggcacc cccgccgtca accgctgaac
     4501 ggcccgccgc ggaggcgcgg ggcgggcggg ccccgccgcg cgcctccgca gcgggtgcgc
     4561 ggggtgcccc ggcgctcccc gacccaccga cccgccgaca cccggatccc ccggtcgcga
     4621 cccgcgccgg gggatccggc gcgtccaccg ccgcgtgcgc cgaaacggcc gcgatacggc
     4681 ggcgatagcc gacggcccga cgatgggcgc aagcgccgcg tccgggccgg gaacggcgtc
     4741 gtggcactgc tcgaaggccc gtcgccgccg cgccccgcgc ggctgccggc cgaccgcgcc
     4801 gcccgccccg ggccgccgtt cccgggccgc cgtggcggct cccccgaccc cggcccccgc
     4861 ggcgcgcacg acgacaactg cacgcagttc ctgcgagaaa acagggcctc gtggccgccg
     4921 gcctgacccg gccgccgcgt cccgctccgc ccgggcgctg ccgcgcccgg gcgtccacca
     4981 cgtcagaagg gttgtccggc atgcgtttga acaggcgaga gatggtggcc ggcgtcgccg
     5041 gcacggcgct ggtggccgcc gcggcggcca ccccgctggt gacaggttct ggcggcgggg
     5101 cggacgcgca cgccgcgcac ggcggcgagg gcggcgcggg cgccggggac gccggggagt
     5161 acgtcgagac gtaccagggc cgcaccattc gggtgctgcc cgaggccgcg ggcggcggcg
     5221 tgctcatcga cgaccggccg ctgcacctga tgaagttcgg cgacgacgcg tacctcagct
     5281 ccatgtgcca ctacgagatg gcgccctccc cgctgcacgc cgcccgccgg gccgtggagg
     5341 agctgcgcgg agcggccctc ctgccggccg cgcacggctc gcacggcacg cacgtgacgg
     5401 tcgtctgacg ccaccaccgc tcaccagccg cacggaccca gccgccacag gaaccgaggg
     5461 gaccccccat ggtgcacatc cgcaagaacc acctggacat gacccgcgag gagaagcgcc
     5521 gcttcgtgca cgcggtacgc gagatcaagc ggcgcggcat ctacgacaga ttcgtcgacc
     5581 tgcacatacg catcaactcg cgcgactacc tcgacaagga gacggggaag cggctcggcc
     5641 acatcaaccc cggcttcctg ccctggcacc ggcagtacct gatgcgcttc gagcgggagc
     5701 tccagcgcgt cgacccgcgc gtcaccctcc cctactggga ctggacggtc gaccacggcg
     5761 aggactcccc gctatgggac gaggagttca tgggcggcaa cgggcgtccg ggcgaccggc
     5821 gggtgatgac ggggccgttc gcccgggaca acggctgggt gctcaacatc agcgtggtcc
     5881 cggtcggcga ggagaacccc gcgctcaacg gcaactacac gcacgacgac cgcgacttcc
     5941 tggtgcgcga catggccacc ctgacggact cgctgccgag cccgcaggag cttgaggaca
     6001 cgctcgcgct gccggtctac gactgcccgc cgtggaacca cacctcgggc ggcgagccgc
     6061 cctacgagag cttccgcaac cacctggagg ggtacaccaa gttcccctgg gagacgaagt
     6121 tcggcaagct gcacggggcc gggcacctgt gggtgggcgg ccacatgatg tacatcggct
     6181 cgcccaacga cccggtgttc ttcctcaacc actgcatgat cgaccgctgc tgggcgctgt
     6241 ggcagcagcg gcaccccgac gtgccccact acctgccgct gcacgacacc ccggacgtgc
     6301 ccgacctgca caccccgctc gggccctggc acacgctgac gcccgccgac ctgatcgacc
     6361 acacccggtg gtaccgctac gacagctgac caccgccgcg gcgggccgcg acggctcccc
     6421 ccgggccgtc cggcccccgc ccggcgggcg gccgggaccc cggccgcccg ccgccccccg
     6481 ccccgccgtt cgccgccgcc gaccggagtc cctggagccg ccccatgccg ttcgcccgcc
     6541 gcgcccgcgc ggtcgccgcc caggcggccg tcacggcctt cctgctgagc gtcaccgccg
     6601 cctgcgggcc cggcgggggc ggggacggtt cagggcccga cgacctcgac ctcggggtga
     6661 tccccatcat cgacgtggcc cccgtgcggc tcggcgtcga gcaggggttc ttcgccgagc
     6721 agggcctcga cctcaccatg accgagtcgc agggcggcgc cgcgatcgtg cccgcggtga
     6781 ccagcggcag cctccagatc ggctactcca acatcgtcag cctgctcgtc gccaggagcc
     6841 agggcgttcc ggtgcgcatg gtgtcggtcg gcgcccgggc ctcggccgac gcgctcgacg
     6901 acggctccgg gcagctgatg gcggccgacg agggcatcac cgacgtcgcg gacctgcgcg
     6961 gccggacggt ggccgtcaac acgctgctgg ggatcaacga ggtcgccgtc cgcaccggcc
     7021 tcgaacgcca cggcctgtcg gccgacgacg tctccctggt cgaactgccc atcccgaaca
     7081 tgcccgccgc cctcgccgcc ggcgacgtgg acgcggccat gctcagcgag ccgttcacca
     7141 cgatcgccga ggcggacggc gcccacgcgg tcccggtcag ctacgccgcc atgggcgagg
     7201 gcctgccgat cgcgggctgg ttcacctccg agtccttcgc ccgggagcac cccgatgtgc
     7261 tggaacggtt caccacggcg ctcgaacggt ccctgcggta cgccgaggag cacccggacg
     7321 aggcgcgggc cgtgctggac agctacctcg acctggcgga cggcgtgagc gccgaggtga
     7381 ccctgcccgg ctgggacccg gccaccgagc cggccgagat cgaggacgtg gcccggctga
     7441 cggccgaggc cgggctgatc gaggacctgg gcccgctgga cgggctcatc gcgccgtagg
     7501 cgccctcgcg cgtgggccgc cgcaccgacc cgaagggctg ccatggcctg gtaccagcac
     7561 cgccgcacgc gcgcggtgcc cgagtcactg ctcggccccg cgggcctgct gctggccgcc
     7621 gcgctggtcg aggtgctgcc gagagccggc ctcgtgccgg ccgagtacct gccgccgttg
     7681 agcgcgatgg ccggcgcgct cgccggcgag gcgggtgacg cggcgttctg gcgggcgctg
     7741 cgcgacaccc tgacgggctg gggcgcgggc ctggccctcg ccacggcggc cggggtgctg
     7801 ctcggcctcg tgatcggccg ggcggagccg ctgcgccggg cgaccgcgtc caccatcgag
     7861 ttcctgcggc cgatcccctc ggtcgcgctg gtgccgctcg cggtcctgct gcacggcacg
     7921 ggcccgcgcg ccacgctgct gctcgtggtc tacgcggcgg tgtggcccgt cctgctccaa
     7981 gtgctcgcgg gcgtgcggga cgtggacccc gtggcgcgcg acacggcggc cgtcttccgg
     8041 ctcccgaccc tgaccaggct gcgccacctg ctgtggccga cgctgctgcc gtacctgatg
     8101 accgggctgc gcctggccgc gtccgtggcc ctgatcctgg cggtgaccgc gcagctggtc
     8161 atcggctccc ccgggctcgg ccgcgagatc gcgctggccc aggcggcgaa cgcggtggag
     8221 cgcatgtacg cgctggtgat cgtgacgggc ctgctcggcg tgtgcgtcaa cgcgggggcg
     8281 cgggcgctgg agcggcgggt gctgttctgg cacacctcgg agcggacgga ggcggcggca
     8341 tgagccggaa cgcgcccgtg cgcacgcggg agcgcgggcg ctcccgcgtg cggggcgggg
     8401 cgcgcacggc gctgcgggcg gcggcatcgg gcgcggtgcg cctggcgtac gccctcggcc
     8461 tccctgccgc gctgctcgcg ctgtggtggg cgctcaccgc gcgcggcggc agtttctact
     8521 acccgccgct cggcgacatc gccgccgcgt tcaccgacac ctggctgacc ggcgggcggc
     8581 tcgcgcggga cgtggcgccg agcctggcca ggctcgcggc cggctgggcc ggcgcggtgc
     8641 tcctcggcgt gggcctgggc ctgctgcttg ggctgcgacc gaggctgcgg gcgctggccg
     8701 agccgctgct cgccttctgc cgggccgttc cgccgccggt gctgatcccc gtcctcatgc
     8761 tggtggccgg catcggcaac gggatgaagg tcgcggtcat cgtcaccggc gcggtctggc
     8821 cggtgctgct caacacgatc cagggcgtca ggtcgctcga cgaggtgctg tccgacaccg
     8881 cgcgctgcta cggggtgacc ggggcggcgc ggctgcggcg cctggtgctg cccgccgccg
     8941 cgcccgcgat cgtcaccggc atgcggcagg cgctctccct cgcgatcatc ctcatggtga
     9001 tcggcgagat gttcgccagt tcgagcggac tcggcttcgc catcgtccag ttccagcgcg
     9061 gcttcgccat ccccgagatg tggagcggca tcttcctgct gggtctggtc ggcttcggcc
     9121 tctcgctgct gttcgggctg ttcgaggcgc gcgccctcgg ctggtaccac gggcagcgcg
     9181 gcctcgcccg cggcgcgggg ggcgcgcggc gggcggcacg gccgcgggag cgggcgggcg
     9241 gggacacgcg ggccggggac gccggcaccg cttcggcgag ggacgaggag tgacatgacc
     9301 acgcgtacac ccggggcgcg ggccgccgat gccgtggcgc ccggccgcct cgacgtggtg
     9361 ggcctggcca agacctaccg ggaccggcgg cggacggtcg aggccgtccg cgacctgacg
     9421 ttcaccgtcg aggcgggccg gctggcctgc gtcgtcgggc cctcgggggc ggggaagacc
     9481 acgctgctgc ggtgcgtcgc cgggctgctg gcgccgacct cggggaccgt ccgcatcggc
     9541 ggcgagcccg tgcaggcgcc gccgcccggc atggccgtcg tcttccagga gtacgcgcgc
     9601 agcctcctgc cgtggctgac ggtcgcgcgc aacgtcgaac tcccgctgcg ccacaagaag
     9661 ctgccgaggg ccgagcggga gcgcctggtg gcgcgttcgc tcgcggccgt cgggctcgcg
     9721 gacgcgtcgg cggcccaccc ctggcagctc tccggcggca tgcagcagcg ggtcgccatc
     9781 gcccgcgcgc tcgcgtacga gcccgacgtg ctgctgatgg acgagccgtt cgccgccgtc
     9841 gacgcgcaga cccgcgccga ccttgaggac ctgacccgcg ccctgtggcg ggagcgcggc
     9901 atgacggtgc tgttcgtgac gcacgacatc gacgaggccg tctacctcgg ggagcgggtg
     9961 ctggtgctgt ccgcggcgcc gaccgtcgtc ctgcgcgtga tcgagatcga tctgcccgag
    10021 gagcgcgagc agttggccac gcgcgccctg ccgcggttcg ccgaactgcg ggccgaggtg
    10081 ttcggcctgg tcaggcaggc caagacgtac cacgacgcgc cgggcgcgcg gacgtgaaca
    10141 gcggcgccgg tgacgacatc ctgcgcggca cgctcgcgga gctgacctgg ccggaggtgg
    10201 cgcgggccgc ccgcgagggg gcggtactgc tgtgggcgtt cggcgtgatc gagcagcacg
    10261 gcccgcacct gccgacgggc accgacgtct acctgccgag cgcctggctg cgcgcggtgc
    10321 ggcggcacct ggcggacctg ggcgtgcccg cgctgatcgt gccgccctac tactggggcg
    10381 tcaacgtcgt gtcggccggc ttccccgc
//
