LOCUS       NZ_CP084541            21083 bp    DNA     linear   CON 20-NOV-2024
DEFINITION  Streptomyces marincola strain SCSIO 64649 chromosome, complete
            genome.
ACCESSION   NZ_CP084541
VERSION     NZ_CP084541.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces marincola
  ORGANISM  Streptomyces marincola
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 6629020)
  AUTHORS   Shi,S.
  TITLE     Strepomyces indimicinicus sp. nov., an antibiotic producing
            actinomycetes isolated from the marine environment
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6629020)
  AUTHORS   Shi,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2021) Key Laboratory of Tropical Marine
            Bio-resources and Ecology, South China Sea Institute of Oceanology,
            Chinese Academy of Sciences, 164 Xingang West Road, guangzhou,
            Guangdong 510301, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. V6.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 444.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_020410765.1-RS_2024_11_18
            Annotation Date                   :: 11/18/2024 03:45:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,763
            CDSs (total)                      :: 5,689
            Genes (coding)                    :: 5,612
            CDSs (with protein)               :: 5,612
            Genes (RNA)                       :: 74
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 77
            CDSs (without protein)            :: 77
            Pseudo Genes (ambiguous residues) :: 0 of 77
            Pseudo Genes (frameshifted)       :: 21 of 77
            Pseudo Genes (incomplete)         :: 60 of 77
            Pseudo Genes (internal stop)      :: 2 of 77
            Pseudo Genes (multiple problems)  :: 6 of 77
            CRISPR Arrays                     :: 10
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:57:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 554618
            Orig. end                         :: 575701
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP084541.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21083
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="4"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21083
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21083
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11083](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11083
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            complement(491..1657)
                     /locus_tag="LC193_RS02275"
                     /old_locus_tag="LC193_02275"
     CDS             complement(491..1657)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006141668.1"
                     /locus_tag="LC193_RS02275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_02275"
                     /product="glycerophosphodiester phosphodiesterase"
                     /protein_id="WP_226070876.1"
                     /transl_table=11
                     /translation="MAAHQTAGADAGHPGRRALLGMTAGAAGAAALLGTAAPAVAGSRP
                     GARDLSRELPVPTVVAHRGASGYRPEHTIGAYQLGLDMGADIIEQDLVPTKDGHLVCRH
                     ENDISGTTDVADHPEFADRRTTKTVDGQELTGWFTEDFTLRELKTLRAVERIPEQRPNN
                     TLYDGRWAVPTFEEVLDWAAEQGRERGRPVWLYTETKHPTYFRSLGLGLEEPLARLLRR
                     HRLHRANSRLILQSFEPSSMERMARLVDTPRVVLLSSAGSRPWDFVESGDPRTVADLVT
                     RRGLREIARYAQGIGPTLDLVIPRAADGSLGRPTSLVEDAHRAGLLVHPYTLRNENRYL
                     PAEFRRGEDPHAYGDVFGALDAYFATGIDGVFADHPDTALLAAADFRD"
     gene            1892..2572
                     /locus_tag="LC193_RS02280"
                     /old_locus_tag="LC193_02280"
     CDS             1892..2572
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1141: acyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016905432.1"
                     /locus_tag="LC193_RS02280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_02280"
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase"
                     /protein_id="WP_086161530.1"
                     /transl_table=11
                     /translation="MSRFVLLKVLLGPLLKLFFRPRVEGIRQIPADGPVILAGNHLTFI
                     DSIILPLVMERQVFFIGKDEYVKGRSLRGRLMAWFFTAVGMIPVDRDGGHGGVAALMTG
                     RRVLEEGKVFGIYPEGTRSPDGRLYRGRTGIARLTLMTGAPVVPFAMIGTDRVQPGGRG
                     LPRVGRGRRITVRFGQPLDFSRYEGMDRDRYVLRAVTDEVMTEVMRLSGQEYVDMYATK
                     AKAA"
     misc_feature    1934..1950
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 15.95"
                     /tool="antismash"
     gene            complement(2600..3571)
                     /locus_tag="LC193_RS02285"
                     /old_locus_tag="LC193_02285"
     CDS             complement(2600..3571)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018103826.1"
                     /locus_tag="LC193_RS02285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_02285"
                     /product="aldo/keto reductase"
                     /protein_id="WP_226070878.1"
                     /transl_table=11
                     /translation="MAFSRFTPAATGTARIGLGLAAVGRPGYINLGRARDLPAPRTPEA
                     LRARTHQLLDAAHAAGVRYLDTARSYGRAEEFLADWLTGRPEATDVVVGSKWGYTYTAD
                     WRADADVHEVKDHGAATFDRQWAESRALLGGRLDLYQIHSATQDSRVLADPAVLDRLAG
                     LADTGVDVGLSTSGPRQAETIRAALEIERGGRPLFRTVQATYNVLEQSAAPALAEAHAA
                     GRTVIVKEALANGRLAGAEAPGELREVADATGTGPDAVALAAVLAQPWTGIVLSGAATE
                     EQLADNLAAARLRLDAAHLDAFTRLAEPPDAYWRSRSALPWT"
     gene            complement(3657..4466)
                     /locus_tag="LC193_RS02290"
                     /old_locus_tag="LC193_02290"
     CDS             complement(3657..4466)
                     /NRPS_PKS="Domain: Abhydrolase_1 (29-123). E-value:
                     6.2e-20. Score: 63.8. Matches aSDomain:
                     nrpspksdomains_LC193_RS02290_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005317055.1"
                     /locus_tag="LC193_RS02290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_02290"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_226070880.1"
                     /sec_met_domain="Thioesterase (E-value: 1.1e-06, bitscore:
                     27.4, seeds: 16, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 9.3e-14, bitscore: 50.0,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.9e-21, bitscore:
                     76.0, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENEPSVPLRYADVRGLRLAYADFGGTGRPLLALHGHFGRARMFA
                     PLAAALGSGHRVIALEQRAHGRSGRDGDVHPDAYLEDAATFLRDLGAGPAVVLGHSAGG
                     VTAFRLAARHPELVAALIVEDHGALNRQPDVANPVLDISGWPRRTGSLAGLRRAVEAHG
                     IPDAGYFLESATEYEDGWGFLFDHDQLMESQRLLMGDWWPDWLASTCPALLIHGTESFV
                     LPTAMAHAMAERRPRTTLREFPGRGHWVHDEDPEGFARAVADFLATL"
     aSDomain        complement(4098..4379)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_LC193_RS02290_Abhydrolase_1.1"
                     /evalue="6.20E-20"
                     /label="LC193_RS02290_Abhydrolase_1.1"
                     /locus_tag="LC193_RS02290"
                     /protein_end="123"
                     /protein_start="29"
                     /score="63.8"
                     /tool="antismash"
                     /translation="PLLALHGHFGRARMFAPLAAALGSGHRVIALEQRAHGRSGRDGDV
                     HPDAYLEDAATFLRDLGAGPAVVLGHSAGGVTAFRLAARHPELVAALIV"
     CDS_motif       complement(4128..4193)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_LC193_RS02290_0001"
                     /evalue="2.90E-06"
                     /label="NRPS-te1"
                     /locus_tag="LC193_RS02290"
                     /protein_end="113"
                     /protein_start="91"
                     /score="19.8"
                     /tool="antismash"
                     /translation="AGPAVVLGHSAGGVTAFRLAAR"
     misc_feature    4625..4634
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.45"
                     /tool="antismash"
     gene            4679..5692
                     /locus_tag="LC193_RS02295"
                     /old_locus_tag="LC193_02295"
     CDS             4679..5692
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009326279.1"
                     /locus_tag="LC193_RS02295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_02295"
                     /product="Gfo/Idh/MocA family protein"
                     /protein_id="WP_226070882.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 2.1e-24, bitscore:
                     84.9, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 3.3e-26,
                     bitscore: 90.1, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADGGKGGAVAADRPVRWGILATGGIAAKLAGDLADLPDAEVAAV
                     ASRAPGPAAEFARRFDIPRSHGSWADLAADPDVDVVYVATPHSAHHAATRLCLDAGKPV
                     LCEKPFTLTAAEAKDLVGLARSRGVFLMEAMWMNCNPVIRRMADLVRDGAIGEIRTIHA
                     DFGIGGPLDPGHRLLDPALGGGALLDLGVYPVSFAHLLLGEPSEVAAWARLRDGVDENT
                     GMLLGHASGAVAALTCSLVADTARTASVTGTGGRIEFPRGFFHPERFVLHRDGREPEEF
                     SGPGPAGSFAHQAAEVMRCLRAGETESPLVPLDDSLAVMRTLDAVRDRIGLRYPGE"
     gene            complement(5741..7183)
                     /gene="argH"
                     /locus_tag="LC193_RS02300"
                     /old_locus_tag="LC193_02300"
     CDS             complement(5741..7183)
                     /EC_number="4.3.2.1"
                     /GO_function="GO:0004056 - argininosuccinate lyase activity
                     [Evidence IEA]"
                     /GO_process="GO:0042450 - arginine biosynthetic process via
                     ornithine [Evidence IEA]"
                     /codon_start=1
                     /gene="argH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014145959.1"
                     /locus_tag="LC193_RS02300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_02300"
                     /product="argininosuccinate lyase"
                     /protein_id="WP_226070884.1"
                     /transl_table=11
                     /translation="MSADQPEVRLWGGRFAHGPAEALERLSASVHFDWRLAPYDIAGSR
                     AHARVLHRAGLLTAEELDRMLAGLDRLAADVESGAFTGTVADEDVHTALERGLIERLGP
                     ELGGKLRAGRSRNDQVATLFRMYLRDHARIVAGLLAELQGALIGLAEAHPDVPMPGRTH
                     FQHAQPVLFSHHVLAHVQALSRNAERLRQWDARTAVSPYGSGALAGSSLGLDPEAVARD
                     LGFEGGSAANSIDGTSSRDFVAEFAFITAMAGVDISRIAEEVIVWNTKEFSFVTLHDSF
                     STGSSIMPQKKNPDIAELARGKSGRLIGNLTGLLATLKALPLAYNRDLQEDKEPVFDSC
                     DQLEILLPAFTGMIATLKVNRERMAELAPAGFSLATDVAEWLVKRGVPFRVAHEVAGEC
                     VRVCEAEGIELDALTDEQFAKISPHLTPEVRTVLTVEGALAARDARGGTAPAAVAVQLR
                     EAKEDLARQLEWARRPAGPVAG"
     gene            complement(7180..8376)
                     /locus_tag="LC193_RS02305"
                     /old_locus_tag="LC193_02305"
     CDS             complement(7180..8376)
                     /EC_number="6.3.4.5"
                     /GO_function="GO:0004055 - argininosuccinate synthase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006526 - L-arginine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1291: argininosuccinate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018836804.1"
                     /locus_tag="LC193_RS02305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_02305"
                     /product="argininosuccinate synthase"
                     /protein_id="WP_226070894.1"
                     /transl_table=11
                     /translation="MTQRVVLAYSGGLDTSVCIGWIAEATGAEVVAVAVDVGQGGESLD
                     VIRKRALACGAVEAEVVDAKDEFAQEYCLPAIKANGLYMDRYPLVSALSRPVIVKHLVA
                     AARKHGADTVAHGCTGKGNDQVRFEAGISSLAPDLTCIAPVRDYAMTRDKAIAFAESKG
                     LPIATSKKSPYSIDANVFGRAIETGFLEDIWNGPIEDIYEYTQNPATPREADEVVITFE
                     RGVPVAVDGRAVSVLQAVQELNERAGAQGVGRIDIVEDRLVGIKSREVYEAPGAIALIT
                     AHQELENVTVERELARYKRQVEQRWSELVYDGLWYSPLKRALDGFVEEANEHVSGDIRM
                     TLHGGRAVVTGRRSGESLYDFSLATYDTGDTFDQSQAKGFIDIFGLSTKIAARRDLAQ"
     misc_feature    8401..8419
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.21"
                     /tool="antismash"
     gene            8766..9332
                     /locus_tag="LC193_RS02310"
                     /old_locus_tag="LC193_02310"
     CDS             8766..9332
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018843118.1"
                     /locus_tag="LC193_RS02310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_02310"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_226070896.1"
                     /transl_table=11
                     /translation="MLSHPLGPEARLGPLEPWQAEELAAYTDRARDHLAPWLPWTRSVT
                     DADSARRFLRRFAESQAADGPRLYGIWLSGELVGGMMYRLFDARQGSCELGAWLSPGAE
                     GRGLVTGAATAMIDWAVRTRGLARVEWLVSPDNVRSIAVARRLGMTHEGTLRSVFEMDG
                     KRHDLEVWAVLGEEWRQRAAPHSIG"
     misc_feature    9728..9739
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     gene            10001..11083
                     /locus_tag="LC193_RS02315"
                     /old_locus_tag="LC193_02315"
     CDS             10001..11083
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019435052.1"
                     /locus_tag="LC193_RS02315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_02315"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_226070898.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.1e-54, bitscore:
                     183.8, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTVPHTADEHHTALDSLRRARELLDPALRTWVHRLPAPVARVAS
                     YHFGWTDAAGRPDSAPAGKALRPALVFGCAEAVGAAPEDAVGPAVAVELVHNFSLLHDD
                     ILDGDTTRRHRTTAWAVFGSSAALLAGDALLIHAGRVLTEQPAGLASLTGIRWLSEATT
                     QLIEGEQTDISFEERTQVTLAECLAMTERKTAALLACSCALGALWGGGSPEAIEAMRRF
                     GTHLGMAFQLTDDLLGIWGDPAVTGKPAGADLVSRKKSLPVVAALDSGTPAARRLAELY
                     LPGGGASGADGGRGREAPDPELTARLAGLVEEAGGRAWAEQAAQEELRLALQCLDAARP
                     EPAAGERLAALARLACRRDR"
     gene            complement(11156..11740)
                     /locus_tag="LC193_RS02320"
                     /old_locus_tag="LC193_02320"
     CDS             complement(11156..11740)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0006525 - arginine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003958363.1"
                     /locus_tag="LC193_RS02320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_02320"
                     /product="arginine repressor"
                     /protein_id="WP_226070900.1"
                     /transl_table=11
                     /translation="MTEESGAAPASPRARAAASAAGPAVPQTRAARHRRIVDILNRQPV
                     RSQSQLAKLLADDGLTVTQATLSRDLDELGAVKIRNTGGELIYAVPSEGGYRTPRVPLG
                     ESAKEERMARLAGELLISAEASANLVVLRTPPGAAQFLASAIDQAEVHDILGTIAGDDT
                     LLLISRDPAGGQSLADHLLRLAQKGKEEPEG"
     gene            complement(11757..12980)
                     /locus_tag="LC193_RS02325"
                     /old_locus_tag="LC193_02325"
     CDS             complement(11757..12980)
                     /EC_number="2.6.1.11"
                     /GO_function="GO:0008483 - transaminase activity [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0006525 - arginine metabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (35-347). E-value: 2.7e-98.
                     Score: 321.0. Matches aSDomain:
                     nrpspksdomains_LC193_RS02325_Aminotran_3.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009713773.1"
                     /locus_tag="LC193_RS02325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_02325"
                     /product="acetylornithine transaminase"
                     /protein_id="WP_226070902.1"
                     /sec_met_domain="Aminotran_3 (E-value: 5.2e-108, bitscore:
                     359.7, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNAPAHPAPAAGNASFAARWRGALMDNYGTPRLALTHGEGARLW
                     DADGNAYLDFVGGIAVSSLGTGHPAVVRAVSEQIARLGHVSNLYIAEPPVALAERLLGL
                     AGRPGRVFFSNSGAEAVEAAFKIGRLTGRPHMVATEGGFHGRTMGALALTGQPKKQQGF
                     GPLPGEVTHVPYGDADALRAAVTERTALVIIEPVQGENGVVVPPEGYLTAAREITGATG
                     TLLVLDEVQTGVGRTGHWFAGQAEGVEPDLVTLAKGLGGGLPIGATLAFGAAAELLAPG
                     GHGSTFGGNPVACAAALAVLDTIESEHLLQRVKEAGERLRDGIWRLGHPLVDRVRGAGL
                     LLGIVLTEPRAPQAQQAAQDAGLLVNAVAPDVLRLAPPLIIGDAEIDAFLTALPGVLDI
                     VDTASGER"
     aSDomain        complement(11940..12875)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_LC193_RS02325_Aminotran_3.1"
                     /evalue="2.70E-98"
                     /label="LC193_RS02325_Aminotran_3.1"
                     /locus_tag="LC193_RS02325"
                     /protein_end="347"
                     /protein_start="35"
                     /score="321.0"
                     /tool="antismash"
                     /translation="LTHGEGARLWDADGNAYLDFVGGIAVSSLGTGHPAVVRAVSEQIA
                     RLGHVSNLYIAEPPVALAERLLGLAGRPGRVFFSNSGAEAVEAAFKIGRLTGRPHMVAT
                     EGGFHGRTMGALALTGQPKKQQGFGPLPGEVTHVPYGDADALRAAVTERTALVIIEPVQ
                     GENGVVVPPEGYLTAAREITGATGTLLVLDEVQTGVGRTGHWFAGQAEGVEPDLVTLAK
                     GLGGGLPIGATLAFGAAAELLAPGGHGSTFGGNPVACAAALAVLDTIESEHLLQRVKEA
                     GERLRDGIWRLGHPLVDRVRGAGLLLGIVLT"
     gene            complement(12977..13894)
                     /gene="argB"
                     /locus_tag="LC193_RS02330"
                     /old_locus_tag="LC193_02330"
     CDS             complement(12977..13894)
                     /EC_number="2.7.2.8"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0003991 - acetylglutamate kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006592 - ornithine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="argB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1174: acetylglutamate kinase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014175086.1"
                     /locus_tag="LC193_RS02330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_02330"
                     /product="acetylglutamate kinase"
                     /protein_id="WP_086161519.1"
                     /transl_table=11
                     /translation="MTHAPARKHTALPKARILIEALPWLTRHHGKTVVIKFGGNAMVDD
                     DLKAAFAQDVAFLRHAGLRPVVVHGGGPQITAQLERLGLTSEFRAGLRVTTPETMDVVR
                     MVLAGQVQRELVGLLNRHGPLAVGMTGEDARLMSAVRRYADVDGERVDIGRVGDVTEVD
                     TGAVRALLDDGRVPVISSIARSADDESVYNVNADTAAAALAAALGAETLMVLTDVEGLY
                     ADWPASDEVISRLTESQLEKLLPDLASGMVPKMEGCLFAVRNGVRTARVIDGRVQHSIL
                     LEIFTDEGIGTMVVPDAAAKGEPT"
     gene            complement(13891..15039)
                     /gene="argJ"
                     /locus_tag="LC193_RS02335"
                     /old_locus_tag="LC193_02335"
     CDS             complement(13891..15039)
                     /EC_number="2.3.1.1"
                     /EC_number="2.3.1.35"
                     /GO_function="GO:0004358 - glutamate N-acetyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006526 - L-arginine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="argJ"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1220: bifunctional ornithine"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325166.1"
                     /locus_tag="LC193_RS02335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_02335"
                     /product="bifunctional glutamate
                     N-acetyltransferase/amino-acid acetyltransferase ArgJ"
                     /protein_id="WP_226070904.1"
                     /transl_table=11
                     /translation="MSVTAAQGFTAAGVAAGIKDSGLDLALVVNQGPRSAAAGVFTSNR
                     VKAAPVLWSEQVLKGGSVTAVVLNSGGANACTGPLGFQDTHATAERAADVLGLNAAEVA
                     VASTGLIGTRLPTEKLLAGVGTAAAELTAHGGERAALAIMTTDTVHKTAVVEGEGWRVG
                     GMAKGAGMLAPGLATMLVVLTTDADVEAPALDRALRAATRTTFDRVDSDGCMSTNDTVL
                     LLASGAAGVTPDEAEFAEAVRAVCADLALQLVKDAEGASKDIRVEVVGAATEDDALEAA
                     RSIARNNLLKCAVHGEDPNWGRVLAAVGTTSAAFEPDRLAVAINGVWVCRDGSIGEDRS
                     LVDMRYREVTITADLGAGDASVVVWTNDLTADYVHENSAYSS"
     gene            complement(15036..16064)
                     /gene="argC"
                     /locus_tag="LC193_RS02340"
                     /old_locus_tag="LC193_02340"
     CDS             complement(15036..16064)
                     /EC_number="1.2.1.38"
                     /GO_function="GO:0003942 -
                     N-acetyl-gamma-glutamyl-phosphate reductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070401 - NADP+ binding [Evidence IEA]"
                     /GO_process="GO:0006526 - L-arginine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0006592 - ornithine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="argC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1219: N-acetyl-gamma-glutamyl-phosphate reductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016639241.1"
                     /locus_tag="LC193_RS02340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_02340"
                     /product="N-acetyl-gamma-glutamyl-phosphate reductase"
                     /protein_id="WP_226078450.1"
                     /transl_table=11
                     /translation="MVVRAAVAGASGYAGGELLRLLLGHPEVEIGALTGHANAGQPLGA
                     LQPQLGPLADRVLAPTSAESLAGHDVVFLALPHGQSGALAAQLGDETLVIDCGADFRLS
                     DAADWERFYGSPHAGTWPYGLPELPGARDALKGARRVAVPGCYPTAVTLALFPAYAARL
                     VEPEAVVVAASGTSGAGRSLKTHLLGSEVMGSMSPYGVGGTHRHTPEMIQNLSGVAGER
                     VSVSFTPMLAPMPRGILATCSAAARPGVTAARLRETYERALAAEPFVRLLPEGQWPSTA
                     AVAGSNAVAVQVALDEAAGRVIAISAVDNLTKGTAGGAVQSMNLALGLPEELGLSTIGV
                     AP"
     misc_feature    16083..16096
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.22"
                     /tool="antismash"
     misc_feature    complement(16084..16097)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.39"
                     /tool="antismash"
     gene            complement(16200..16784)
                     /locus_tag="LC193_RS02345"
                     /old_locus_tag="LC193_02345"
     CDS             complement(16200..16784)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006140213.1"
                     /locus_tag="LC193_RS02345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_02345"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_226070906.1"
                     /transl_table=11
                     /translation="MAEPARRRPMRADARRNRDRIVAAAQEVFAADGARASLEEIARRA
                     GVGSATLHRHFPTRRSLLDVVFHDRVEALCAKAGEHADRREPGDALVAWLGDLNVYAAA
                     SHGLVSSLLRDGPDADLLKRNDDCQAMITAAAGELLDRAQRAGAARPGVRVEDLLALVS
                     ALSLAAEQRDDDEGRANRLLDIAVNGVLLPR"
     gene            16888..17850
                     /locus_tag="LC193_RS02350"
                     /old_locus_tag="LC193_02350"
     CDS             16888..17850
                     /NRPS_PKS="Domain: PKS_ER (14-313). E-value: 1.8e-40.
                     Score: 130.9. Matches aSDomain:
                     nrpspksdomains_LC193_RS02350_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003983099.1"
                     /locus_tag="LC193_RS02350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_02350"
                     /product="NAD(P)-dependent alcohol dehydrogenase"
                     /protein_id="WP_226070908.1"
                     /sec_met_domain="ADH_N (E-value: 2.2e-05, bitscore: 22.7,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 4.1e-09, bitscore:
                     34.9, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAVQYDRFGPPEVLRVDEVPVPRPGRGEVLVEVRAASVDAGEIA
                     FRSGRLRRVSRAGFPRRTGGDFTGRVSAVGPGVRTWRAGDAVWGLMPHFAFGSMADYVS
                     VPQERLARAPENLSLLEAAALPVSGTTALTALTDKARLASGERLLVRGATGGVGSIAVQ
                     LGKAIGAHVTALASAGNLAWVTALGADEARDYRTTRPEDLERFDVILDVVGTDLRAYRA
                     RLTRRGRMVALAFDPDRLLTSILASGARAAVAPRRFKLFSNNPSADRIAELTRLAEAGS
                     VRPVVDSVFPATGVAEAHRRLEAGGVRGKYLIDMERGRP"
     aSDomain        16930..17826
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_LC193_RS02350_PKS_ER.1"
                     /evalue="1.80E-40"
                     /label="LC193_RS02350_PKS_ER.1"
                     /locus_tag="LC193_RS02350"
                     /protein_end="313"
                     /protein_start="14"
                     /score="130.9"
                     /tool="antismash"
                     /translation="LRVDEVPVPRPGRGEVLVEVRAASVDAGEIAFRSGRLRRVSRAGF
                     PRRTGGDFTGRVSAVGPGVRTWRAGDAVWGLMPHFAFGSMADYVSVPQERLARAPENLS
                     LLEAAALPVSGTTALTALTDKARLASGERLLVRGATGGVGSIAVQLGKAIGAHVTALAS
                     AGNLAWVTALGADEARDYRTTRPEDLERFDVILDVVGTDLRAYRARLTRRGRMVALAFD
                     PDRLLTSILASGARAAVAPRRFKLFSNNPSADRIAELTRLAEAGSVRPVVDSVFPATGV
                     AEAHRRLEAGGVRGKYLI"
     CDS_motif       17320..17379
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_LC193_RS02350_0001"
                     /evalue="2.60E-05"
                     /label="PKSI-ER_m5"
                     /locus_tag="LC193_RS02350"
                     /protein_end="164"
                     /protein_start="144"
                     /score="16.8"
                     /tool="antismash"
                     /translation="GERLLVRGATGGVGSIAVQL"
     gene            complement(17890..18435)
                     /locus_tag="LC193_RS02355"
                     /old_locus_tag="LC193_02355"
     CDS             complement(17890..18435)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003985011.1"
                     /locus_tag="LC193_RS02355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_02355"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_226070910.1"
                     /transl_table=11
                     /translation="MFTWRRIGERDFPLLRSWLEQAHVRRWWNHETSAAAVARDFGPAA
                     RGEEPSEDLLAFLDGRPVGLVQRSRLCDYPEYLAELAAVVPVPDGAMTIDYLIGAPEDT
                     GRGVGTAMLRSVVERTWTEHPAAPCVLVPVVAANRASWRALERAGLRRVGAGELEPDNP
                     VDDRAHYLYRVDRPGSGG"
     gene            18603..19043
                     /locus_tag="LC193_RS02360"
                     /old_locus_tag="LC193_02360"
     CDS             18603..19043
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988368.1"
                     /locus_tag="LC193_RS02360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_02360"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_226070912.1"
                     /transl_table=11
                     /translation="MTSRPTEARLRDLAALRRVRDRIDREYAQPLDVEALARGAHMSAG
                     HLSRAFRRAYGESPYGYLMTRRIERAMALLRRGDLSVTEVCFTVGCSSLGTFSTRFTEL
                     VGMPPSAYRRRAARATAGIPSCVAKQVTRPVRNREAQVAGRA"
     gene            19054..19476
                     /locus_tag="LC193_RS02365"
                     /old_locus_tag="LC193_02365"
     CDS             19054..19476
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009327339.1"
                     /locus_tag="LC193_RS02365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="LC193_02365"
                     /product="VOC family protein"
                     /protein_id="WP_226070914.1"
                     /transl_table=11
                     /translation="MDVTIHASFLPHDDPDASLAFYRDLLGFEVRDDVGYDGMRWITVG
                     PPGRPGTSIVLQPPAADPGITEEERRTIVEMMAKGTYAGILLAATDLDGVFERLRAGGA
                     EIVQEPAEQPYGVRDCAVRDPAGNLVRLQEPRRDAR"
     misc_feature    complement(19564..19579)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.89"
                     /tool="antismash"
ORIGIN
        1 ccgtgccgct gcatcctcgg gtggacgatg aggcgtccga tgcaggcggt gccgtcggcg
       61 tccacgcgtc ccctgaccgc gccgacgacc tcggggccga gcctggccac caggacgcag
      121 gtctcgctga tctcggcgcg cgcggcggcc agcgtctcgg tcaggggctc gatggaatag
      181 tcgccgtaga gttcggcctc cgactggtag cagaggtact gcaacttcag gatctgctcc
      241 gcgtcctggt ggtcggccag gccgatggtg acgctcatac ccatgtgcac acgcctccgg
      301 tgaggtccgg gccggccgcg cgcaggggtg agggtcgcgc accggccggc gattgccctg
      361 acggcgcagg gtgtgacctg cgccgtcagc attgtgctgg gccgcgggcc gccgggggaa
      421 tgcgccggcg ccaactggct tgtgagattt ccgactcacc ggtacccgga cgggtgaacg
      481 ggccgggcgt tcagtcgcgg aagtcggcgg cggccagcag cgcggtgtcg gggtggtcgg
      541 cgaacacgcc gtcgatcccg gtcgcgaagt aggcgtccag cgcgccgaac acgtccccgt
      601 acgcgtgcgg gtcctcgccg cggcggaact cggcgggcag gtaccggttc tcgttgcgca
      661 gcgtgtaggg gtgcacgagc agtccggcgc ggtgcgcgtc ctcgacgagg gaggtggggc
      721 ggccgagcga gccgtcggcc gcgcgcggga tgacgaggtc gagggtgggg ccgatgccct
      781 gcgcgtaccg ggcgatctct cgcagcccgc ggcgcgtgac gaggtcggcg acggtgcgcg
      841 ggtcgccgga ctccacgaag tcccacgggc gggagccagc cgaggagagc agcacgacgc
      901 gcggggtgtc cacgagcctg gccatgcgct ccatgctgga gggctcgaag gactggagga
      961 tcaggcggga gttggcgcgg tgcagccggt gccggcgcag caggcgggcg agcggttcct
     1021 ccaggcccag gcccagggag cggaagtagg tggggtgctt ggtctcggtg tacagccaca
     1081 ccggacggcc ccgctcgcgc ccctgctcgg cggcccagtc gaggacttcc tcgaaggtcg
     1141 ggacggccca acgtccgtcg tacagggtgt tgttggggcg ctgctcgggt atccgctcga
     1201 cggcgcgcag ggtcttcagc tcccggagcg tgaagtcctc ggtgaaccag ccggtcagct
     1261 cctgcccgtc gacggtcttg gtggtgcggc ggtcggcgaa ctccgggtgg tccgcgacgt
     1321 cggtggtgcc ggagatgtcg ttctcgtgcc ggcagaccag gtggccgtcc ttggtgggca
     1381 ccaggtcctg ctcgatgatg tcggccccca tgtcgagccc gagctggtag gcgccgatgg
     1441 tgtgttccgg ccggtagccg gaggcgccgc ggtgggcgac gaccgtgggg acgggcagtt
     1501 cgcgggagag gtcgcgcgcg cccgggcgcg agcccgcgac cgcgggtgcc gcggtgccga
     1561 gcagggcggc ggcgccggcc gcgccggccg tcatgccgag cagggcccga cgtccggggt
     1621 gccccgcgtc cgcgcctgcc gtctggtgag ctgccatcgt cactccgtag ggctcgtccg
     1681 tcgtcgggcc gcgcgctccg gcggcccgtg atcgcgcccg atcgtaggga agcggcgctg
     1741 tccgcacggg tacatgcggg ggaacggccg gggaatgcgc gtcaaacccg agtatcgggg
     1801 gcgagcaccc ggtgcgcgcg gcgtgccccg gcgcgggtat cgtccctagg catgctgaaa
     1861 cacgcatgcc catgaccgac cggaggggaa gttgtcccgt ttcgtgctgc tgaaggtgct
     1921 gctcggcccg ctgctgaagc ttttcttccg gccccgggtc gagggaatcc ggcagatccc
     1981 cgccgacggg ccggtgatcc tggccgggaa ccacctcacg ttcatcgatt cgatcattct
     2041 gccgctggtc atggagcggc aggtcttctt catcggcaag gacgagtacg tcaagggccg
     2101 ttccctgcgg ggtcgcctga tggcgtggtt cttcacggcc gtcggcatga tcccggtcga
     2161 ccgggacggc gggcacggcg gggtggccgc gctcatgacc gggcggcgtg tcctggagga
     2221 gggcaaggtc ttcggcatct acccggaggg cacccggtca cccgacggac gtctgtaccg
     2281 ggggcgcacc gggatcgcgc ggctcacgct gatgacgggc gcgccggtgg tgccgttcgc
     2341 gatgatcggc accgaccggg tccagccggg ggggcgcggc ctgccgcggg tcggccgggg
     2401 gcgcaggatc acggtgcggt tcggccagcc gctcgacttc tcgcggtacg agggcatgga
     2461 ccgggaccgc tacgtgctgc gtgccgtcac cgacgaggtg atgaccgagg tgatgcgcct
     2521 ctccgggcag gagtacgtgg acatgtacgc caccaaggcg aaggccgcct gagggcgcgc
     2581 cccgcccccg cgccccgcgt caggtccagg gcagcgcgga gcggctgcgc cagtacgcgt
     2641 ccggcggttc ggccagccgg gtgaacgcgt ccaggtgcgc ggcgtccagg cgcagccggg
     2701 cggcggcgag gttgtccgcg agctgctcct cggtggccgc ccccgacagg acgatcccgg
     2761 tccacggctg ggccagcacg gcggcgaggg caacggcgtc gggcccggtg ccggtcgcat
     2821 ccgcgacctc ccgcagctcg cccggcgcct cggccccggc gaggcggccg ttggccagcg
     2881 cctccttgac gatgacggtg cggcccgccg cgtgcgcctc cgcgagcgcg ggggcggcgg
     2941 actgctccag cacgttgtac gtggcctgca ccgtccggaa caggggccgc ccgccccgtt
     3001 cgatctccag cgccgcccgg atcgtctccg cctggcgcgg gccgctggtg gacaggccca
     3061 cgtcgacgcc ggtgtcggcc aggccggcca gccggtcgag cacggccggg tcggccagca
     3121 cccggctgtc ctgggtggcc gagtggatct ggtacaggtc gagccggccg ccgagcagcg
     3181 cccggctctc ggcccactgc cggtcgaacg tggcggcccc gtggtccttg acctcgtgga
     3241 cgtccgcgtc ggcacgccag tccgccgtgt aggtgtagcc ccacttgctg ccgaccacga
     3301 cgtcggtcgc ctccggccgc ccggtgagcc agtcggcgag gaactcctcg gccctgccgt
     3361 aggaacgcgc cgtgtcgagg tagcggacgc cggccgcgtg ggccgcgtcg agcagctggt
     3421 gggtgcgggc ccgcagcgcc tcgggcgtgc gcggcgcggg caggtcgcgg gcccgcccga
     3481 ggttgatgta cccggggcgg ccgacggcgg cgaggccgag cccgatgcgg gcggtgccgg
     3541 tcgcggccgg ggtgaagcgg gagaacgcca tgcggtgacc ttcggaacgt gtgccgccct
     3601 cgcggcggcc tcgggtgcgt gccctcaccg tatccacccc gggcgccgcg gccggctcag
     3661 agggtggcga ggaagtccgc gacggcgcgg gcgaagccct cgggatcctc gtcgtggacc
     3721 cagtgcccgc ggccggggaa ctcccgcagc gtggtgcgcg gccggcgttc ggccatcgcg
     3781 tgggccatcg cggtgggcag cacgaagctc tccgtgccgt ggatcagcag cgcggggcag
     3841 gtcgaggcga gccagtcggg ccaccagtcg cccatgagga ggcgctggga ctccatcagc
     3901 tggtcgtggt cgaacaggaa gccccagccg tcctcgtact cggtcgcgct ctccaggaag
     3961 tacccggcgt ccgggatgcc gtgcgcctcg acggcccggc gcagtccggc gagcgagccc
     4021 gtgcgccgcg gccagccgct gatgtcgagg acagggttcg cgacgtccgg ctgccggttg
     4081 agcgccccgt ggtcctcgac gatcagggcg gcgaccagct cggggtgacg ggccgcgagg
     4141 cggaacgcgg tgaccccgcc cgcggagtgc ccgagcacga cggcggggcc ggcgccgagg
     4201 tcgcgcagaa acgttgccgc gtcctcaagg taggcgtcgg ggtgcacgtc gccgtcccgt
     4261 ccgctgcggc cgtgcgcgcg ctgttcgagg gcgatcaccc ggtggccgga gccgagcgcg
     4321 gcggccaggg gcgcgaacat ccgggcgcgg ccgaagtgcc cgtgcagggc gagcaggggc
     4381 cggcccgtgc cgccgaagtc ggcgtacgcc aggcgcaggc cgcgcacgtc ggcgtaccgc
     4441 agcggtacgg atggctcgtt ctccatggtg cttcccttca tcccccgcac ggacggtgtc
     4501 ccggccggga cggccggaac gcggcagccg acaatagccg gtggccggtg cggacttggg
     4561 ggcgggggcg gctccggcga tcttgctcac gcggcccgac cgggactgtc acatacgatg
     4621 atcctgattt ctgacgcagc cggggcgtgg accgcgcggc acgaacgagg agttgggcat
     4681 ggcggacggc gggaagggcg gggccgtcgc ggcggaccgc cccgtgcggt ggggcatcct
     4741 ggcgaccggc ggcatcgccg ccaaactggc cggggacctc gcggacctgc cggacgccga
     4801 ggtggccgcg gtggcctccc gcgcgccagg accggccgcg gagttcgccc ggcggttcga
     4861 catcccgcgc tcccacggca gttgggccga cctcgcggcc gaccccgacg tggacgtggt
     4921 gtacgtggcc acgccgcact cggcgcacca cgccgcgacg cgcctgtgcc tcgatgcggg
     4981 caagccggtc ctgtgcgaga agccgttcac cctcaccgcg gccgaggcga aggacctggt
     5041 cggcctggcc aggtcccgcg gcgtcttcct gatggaggcc atgtggatga actgcaaccc
     5101 ggtgatccgg cgcatggccg acctggtgcg ggacggagcg atcggcgaaa tccgcacgat
     5161 tcacgcggac ttcggcatcg gcgggccgct cgacccgggc caccggctgc tcgaccccgc
     5221 cctcggcggc ggcgcgctgc tcgacctggg cgtgtacccc gtgtccttcg cgcacctgct
     5281 gctcggtgag ccgtcggagg tcgcggcgtg ggcccggctg cgcgacgggg tcgacgagaa
     5341 caccgggatg ctgctcggcc acgcctcggg cgcggtggcc gcgctgacct gctcgctggt
     5401 cgcggacacc gcgcgcacgg cgtccgtgac gggcaccggc ggccggatcg agttcccccg
     5461 cggcttcttc caccccgagc ggttcgtgct gcaccgggac ggccgcgagc ccgaggagtt
     5521 ctcggggccc ggccccgccg gttcgttcgc gcaccaggcg gccgaggtca tgcgctgcct
     5581 gcgggccggt gagaccgagt cgccgctggt gccgctggac gacagcctgg ccgtgatgcg
     5641 caccttggac gcggtcaggg accgcatcgg cctgcgctac ccgggcgagt agcgcgcggt
     5701 gccgcggcgg ccggccggcc gccgcggcat ccccgtggct tcagcccgcg accggccccg
     5761 cgggccgccg cgcccactcc agctggcgcg ccaggtcctc cttggcctcg cgcagctgca
     5821 cggccacggc cgcgggcgcg gtgccgcccc tggcgtcgcg cgcggccagg gcgccctcca
     5881 cggtcagcac ggtgcggacc tcgggcgtga ggtgcgggga gatcttcgcg aactgctcgt
     5941 cggtcagcgc gtcgagctcg atgccctccg cctcgcagac cctgacgcac tcccccgcga
     6001 cctcgtgggc cacccggaac ggcacgccgc gcttgacgag ccactcggcg acgtccgtgg
     6061 cgagcgagaa gccggccggc gccagttccg ccatgcgctc ccggttgacc ttcagggtgg
     6121 cgatcatgcc ggtgaacgcc gggagcagga tctccagctg gtcgcaggag tcgaagaccg
     6181 gctccttgtc ctcctggagg tcccggttgt acgcgagcgg cagcgccttg agcgtggcga
     6241 gcagacccgt caggttgccg atgaggcgtc ccgacttgcc cctggccagc tccgcgatgt
     6301 ccgggttctt cttctgcggc atgatcgaac tgccggtgga gaacgagtcg tgcagggtga
     6361 cgaaggagaa ctccttcgtg ttccacacga tgacctcctc cgcgatccgg gagatgtcca
     6421 cgccggccat cgccgtgatg aacgcgaact cggcgacgaa gtcgcgggat gaggtgccgt
     6481 cgatggagtt cgccgcggag ccgccctcga aaccgaggtc gcgggccacg gcctccgggt
     6541 cgaggccgag cgaggagccg gccagcgccc ccgagccgta gggcgagacg gccgtgcggg
     6601 cgtcccactg ccgcaggcgc tcggcgttcc tgctcagggc ctggacgtgc gccaggacgt
     6661 ggtgcgagaa cagcacgggc tgcgcgtgct ggaagtgcgt gcgcccgggc atgggcacgt
     6721 cggggtgcgc ctcggcgagg ccgatcaggg cgccctggag ctcggccagc agaccggcga
     6781 cgatccgcgc gtggtcccgc aggtacatcc ggaagagcgt ggcgacctgg tcgttgcgcg
     6841 accgcccggc gcgcagcttg ccgccgagct cagggccgag ccgctcgatc agcccgcgtt
     6901 cgagcgcggt gtgcacgtcc tcgtcggcca cggtgccggt gaacgcgccg ctctccacgt
     6961 cggcggcgag ccggtcgagg ccggccagca tccgatcgag ctcctcggcg gtcagcagcc
     7021 ccgcccggtg caggaccctg gcgtgggccc gcgagcccgc gatgtcgtag ggcgcgaggc
     7081 gccagtcgaa gtggacggag gcgctcagcc gttcgagggc ctcggccggt ccgtgcgcga
     7141 accggccgcc ccacagccgc acctcgggct ggtcggcact cactgggcga ggtcccgccg
     7201 cgccgcgatc ttggtggaca ggccgaagat gtcgatgaag cccttggcct gcgactggtc
     7261 gaaggtgtcg ccggtgtcgt acgtcgccag gctgaagtcg tacagcgact cgccggagcg
     7321 ccgcccggtg accacggcgc gcccgccgtg cagcgtcatc cggatgtcac cgctgacgtg
     7381 ctcgttcgcc tcttccacga agccgtcgag cgcccgcttc agcggcgagt accacaggcc
     7441 gtcgtagacc agctcggacc agcgctgctc gacctgccgc ttgtagcggg ccagctcgcg
     7501 ctcgaccgtg acgttctcca gctcctggtg cgcggtgatc agcgcgatgg cgccgggtgc
     7561 ctcgtagacc tcgcgggact tgatgcccac caggcggtcc tcgacgatgt cgatgcggcc
     7621 cacgccctgc gcgccggccc gctcgttcag ctcctgcacg gcctggagga cgctgacggc
     7681 ccggccgtcg acggccacgg gaacgccccg ctcgaaggtg atgaccacct cgtcggcttc
     7741 cctgggggtc gccgggttct gcgtgtactc gtagatgtcc tcgatcggcc cgttccagat
     7801 gtcctcaagg aagccggtct cgatggcgcg gccgaagacg ttggcgtcga tggagtaggg
     7861 cgacttcttg ctggtggcga tcggcaggcc cttgctctcg gcgaacgcga tggccttgtc
     7921 ccgggtcatg gcgtagtccc ggacgggcgc gatgcacgtg aggtcggggg ccagggagga
     7981 gatgccggcc tcgaacctga cctggtcgtt ccccttgccg gtgcagccgt gcgccacggt
     8041 gtcggcgccg tgcttgcggg ccgcggcgac gaggtgcttg acgatcacgg gccgcgagag
     8101 ggcggagacg agcgggtagc ggtccatgta gaggccgttg gccttgatcg ccggcaggca
     8161 gtactcctgc gcgaactcgt ccttcgcgtc gacgacctcc gcctcgacgg caccgcaggc
     8221 gagcgcgcgc ttgcggatga catccaggct ctcgccgccc tggccgacgt cgacggcgac
     8281 ggcgacgacc tcggcgccgg tcgcctcggc gatccagccg atgcagacag atgtgtccag
     8341 gccgccggag taggcgagca cgacgcgctg ggtcacggtg tctccttagg atgcatacgc
     8401 tgactggaat aagtatgcag ggtgtcgcat ggttcgtcaa ttcgccaggt cggcggcccg
     8461 agaacgcggc ctcgccgcgg agagaccgcg gaaaagcggt cgcgcggcgg gagccgcccg
     8521 ggcgagcatg gacgcgcgac gacgcctggg ggacgcatgg gggaatcgcc gcgggccgcg
     8581 gcggccggga cgggagggac cgccggggac gggggtacct cccgggtgtc cgccgcgctc
     8641 ggcccgcgcg ggggcgcacc ggcccggacg gcctctccca ggcgatcgcg cccttcacca
     8701 gccgaaccga cgccagggcc gcggatcccg gggacgggcg cccgcggccg gagaggacac
     8761 accacgtgct cagtcatccc ctcggccccg aggcccgcct cggcccgctc gaaccctggc
     8821 aggccgagga gctcgcggcc tacaccgacc gcgcgcggga ccacctggcg ccgtggctgc
     8881 cctggacccg gtcggtgacg gacgccgatt cggcgcggcg cttcctgcgg cggttcgccg
     8941 agagccaggc ggcggacggg ccgcgcctgt acggcatctg gctgtcgggc gaactggtcg
     9001 gcggcatgat gtaccggttg ttcgacgccc ggcagggatc gtgcgagctc ggcgcctggc
     9061 tgtcgcccgg ggctgagggc cgcgggctgg tgaccggggc ggccacggcc atgatcgact
     9121 gggccgtgcg gacgcgggga ctggcgcggg tcgagtggct ggtgagtccg gacaacgtgc
     9181 ggagcatcgc cgtggcccgg cgcctcggca tgacgcacga gggcacgctg cgcagcgttt
     9241 tcgaaatgga cggaaagcgg catgacctgg aggtttgggc ggtgctcggc gaggaatggc
     9301 ggcagcgtgc ggcccctcac tcgatcgggt gattagcgga cggccggcgc ggcagcgcgg
     9361 agcctttggc ctgagaagaa ctccaggtca gctcggctgg ctccccgcct gagggcgcga
     9421 ggttgccccc gtggggcgca cggcgattcc cgaacgcgcc ttccagcgct cccctcgccc
     9481 ggtcaagctg gccgcatgat cagcgatcgg tatgaggggg tgcggggatg accgcggctc
     9541 ccggcccgcc cgcgccgacc gggcggttcc ggcgccccgc acggcggccc gcgcccccgc
     9601 gccctggggg agccgcggtg gggccgccgc cgcggggaac ggtcacgtcc gctgtcacgt
     9661 tggggcaggt gccgggccag ggcgccggcg gcacgacccg ttccccgtgg tacgccccgc
     9721 ccgtcgagga ggtgaacgcc gccatccgga gcctcccgtt gcccggcccc cgcccacgcg
     9781 gcaccggccc cgcgccgcgg tcgggccgcg cgcgggtccg gcccgacggc cccgcggggg
     9841 cgtgccccga ggcgtcgtgg ggcgcggatg gggggcgcgt ccgcgtgcgg ggcgaggccg
     9901 tccgcacggt tcccgggagc cgcgccgccg aagcgccgcg agaggccgcc ctggccctca
     9961 ccgagcaagc ccacgaagcg gaggaaccgg aggccctgcc atgaccaccg tcccccacac
    10021 agcggacgag caccacacag ctctcgactc gttgcgccgg gcgcgcgagt tgctcgaccc
    10081 ggcactgcgc acctgggtgc accgcctgcc cgctcccgtc gcacgggtcg cctcgtacca
    10141 cttcggctgg accgacgccg cgggtcggcc cgacagcgcg cccgcgggca aggccctgcg
    10201 gcccgcgctc gtgttcggct gcgccgaggc cgtcggcgca gcccccgagg acgcggtggg
    10261 gccggccgtc gccgtggagc tcgtgcacaa cttctcgctg ctgcacgacg acatcctcga
    10321 cggcgacacc acccggaggc accggaccac cgcctgggcg gtgttcggct cctcggccgc
    10381 gctgctcgcg ggggacgcgc tgctgatcca cgcgggacgc gtgctcaccg agcagcccgc
    10441 cgggctcgcg agcctcaccg gcatccgctg gctcagcgag gccaccaccc agttgatcga
    10501 gggcgagcag accgacatct cgttcgagga acgcacgcag gtgacgctgg ccgagtgcct
    10561 ggcgatgacc gagcgcaaga cggcggcgct gctggcctgt tcgtgcgccc tcggggcgct
    10621 gtggggcggc gggtcgcccg aggccatcga ggcgatgcgc cgcttcggca cccacctcgg
    10681 catggcgttc cagctcaccg acgacctgct cggcatctgg ggcgacccgg ccgtcaccgg
    10741 caaaccggcg ggtgccgacc tggtcagccg caagaagtcg ctgcccgtgg tcgccgccct
    10801 cgattccggc acgcccgccg cccggcggct cgccgagctg tacctgccgg gcggcggggc
    10861 ctccggggcg gacggcgggc gggggcggga ggcgccggat cccgagctga cggcccgcct
    10921 cgcgggcctg gtcgaggagg cgggcggcag ggcctgggcg gagcaggcgg cgcaggagga
    10981 gctgcggttg gcgctccagt gcctggacgc ggcccgtccc gaacccgccg cgggcgaacg
    11041 gctcgccgcg ctcgcccggc tcgcctgccg cagggaccgc tgagcggacg ggccgcccgg
    11101 agggcacggt gcgactgggg ggcgcccggg aggggagggc gaggccgggg ggcggtcagc
    11161 cctccggctc ctccttcccc ttctgggcca gccgcagaag gtggtcggcc agggactggc
    11221 cgcccgccgg gtcgcggctg atcagcagca gcgtgtcgtc gcccgcgatg gtgcccagga
    11281 tgtcgtggac ctccgcctgg tcgatggcgg aggccaggaa ctgggcggcg cccggcgggg
    11341 tgcgcagcac gaccaggttc gccgacgcct cggccgagat cagcagttcc ccggcgagcc
    11401 tggccatccg ctcctccttg gccgactccc cgagcggcac ccggggcgtg cggtagccgc
    11461 cctcgctcgg cacggcgtag atcagctcac cgccggtgtt gcggatcttc accgcgccga
    11521 gttcgtcgag gtcccggctg agtgtcgcct gggtgacggt cagcccgtcg tcggcgagga
    11581 gcttcgccaa ctggctctgc gaccgcaccg gctggcggtt gaggatgtcg acgatgcggc
    11641 ggtgccgtgc cgcgcgggtc tgcggcacgg cggggcccgc cgcggacgcg gcggctctgg
    11701 cgcgcggcga cgccggtgcg gcacccgact cctcggtcac gttctctctc ccgtgctcat
    11761 cgctctccgc tcgccgtgtc cacgatgtcg agaacgccgg gcagggccgt gaggaacgcg
    11821 tcgatctccg cgtcgccgat gatcagcggc ggggcgagcc gcagcacgtc gggggcgacg
    11881 gcgttcacca gaagtccggc gtcctgagcc gcctgctgcg cctggggggc gcggggctcg
    11941 gtgagcacga taccgagcag cagcccggcg cccctgaccc ggtcgaccaa ggggtggccc
    12001 aggcgccaga tcccgtcgcg cagccgctcc ccggcctcct tgacccgctg gagcaggtgc
    12061 tcggactcga tggtgtcgag cacggccagg gcggcggcgc acgcgaccgg gttgccgccg
    12121 aaggtggagc cgtgcccgcc gggcgccagc agttctgcgg cggcgccgaa cgccagcgtg
    12181 gcgccgatcg gcaggccgcc cccgaggccc ttggcgagcg tgaccaggtc gggttccacg
    12241 ccctccgcct gcccggcgaa ccagtgcccg gtccggccga cgccggtctg cacctcgtcg
    12301 aggacgagca gggtcccggt ggccccggtg atctcgcgcg cggcggtcag gtagccctcg
    12361 ggcggcacca ccacgccgtt ctcgccctgg acgggctcga tgatcaccag cgccgtgcgt
    12421 tcggtgaccg ccgcgcgcag ggcgtcggcg tcaccgtagg ggacgtgcgt gacctcgccg
    12481 ggcagcggcc cgaacccctg ctgcttcttc ggctgcccgg tgagcgcgag cgcgcccatg
    12541 gtgcggccgt ggaagccccc ctcggtggcc accatgtgcg ggcgaccggt gagccggccg
    12601 atcttgaacg cggcctcgac cgcctcggcg cccgagttgg agaagaacac gcggcccggc
    12661 cggcccgcga gcccgagcag gcgttccgcc agggcgaccg ggggctcggc gatgtagagg
    12721 ttcgacacgt ggccgaggcg cgcgatctgc tccgagacgg cccgcacgac ggccgggtgg
    12781 ccggtgccga gcgagctgac ggcgatgccg ccgacgaagt ccaggtaggc gttgccgtcc
    12841 gcgtcccaca gccgggcgcc ctcgccgtgg gtgagggcca gccggggggt gccgtagttg
    12901 tccatcagcg cgccgcgcca gcgggcggcg aacgacgcgt tgccggcggc cggcgcgggg
    12961 tgggcgggtg cgttgctcat gtcggctctc ccttggctgc cgcgtcgggc accaccatcg
    13021 ttccgatgcc ctcgtccgtg aagatctcca gcaggatgga gtgctggacc cggccgtcga
    13081 tgacgcgcgc ggtccgcacg ccgttgcgga ccgcgaagag gcagccctcc atcttcggca
    13141 ccatgccgct ggccaggtcg ggcagcagct tctccagctg gctctcggtg agccggctga
    13201 tcacctcgtc gctcgccggc cagtcggcgt acaggccctc gacgtccgtc agcaccatca
    13261 gggtctccgc gccgagggcg gcggccagcg cggcggcggc ggtgtcggcg ttgacgttgt
    13321 agacgctctc gtcgtcggcg ctgcgggcga tggaggagat gaccgggacg cggccgtcgt
    13381 cgagcagcgc gcggacggct cctgtgtcca cctcggtgac gtcgccgacg cggccgatgt
    13441 cgacccgctc cccgtcgacg tcggcgtagc ggcgcaccgc ggacatcagc cgggcgtcct
    13501 cgcccgtcat gccgacggcc agcggtccgt gccggttgag cagcccgacc agttcgcgct
    13561 ggacctggcc ggccagcacc atgcgcacca cgtccatggt ctcgggggtc gtcaccctca
    13621 gaccggcgcg gaactcggag gtcaggccca gccgttccag ctgcgccgtg atctgcggtc
    13681 cgccgccgtg cacgacgacg gggcgcagtc ccgcgtgcct gaggaacgcg acgtcctggg
    13741 cgaacgcggc cttcaggtcg tcgtcgacca tggcgttgcc gccgaacttg atgacgacgg
    13801 tcttgccgtg gtgacgggtc agccagggca gggcctcgat gaggatgcgc gccttgggca
    13861 gcgcggtgtg tttgcgggcg ggggcgtggg tcatgaggag taggcgctgt tctcgtggac
    13921 gtagtcggcg gtgaggtcgt tggtccagac gacgaccgac gcgtcgcccg cgccgaggtc
    13981 ggcggtgatc gtgacctcgc ggtagcgcat gtcgaccagg gagcggtcct cgccgatgga
    14041 gccgtcacgg cagacccaga ccccgttgat cgcgacggcg agccggtcgg gctcgaacgc
    14101 ggccgaggtg gtgccgacgg ccgcgagcac ccggccccag ttggggtcct cgccgtggac
    14161 cgcgcacttc aggaggttgt tgcgggcgat ggagcgggcc gcctccaggg cgtcgtcctc
    14221 ggtggccgcg ccgacgacct cgacgcggat gtccttggac gcgccttccg cgtccttgac
    14281 gagctggagc gcgaggtccg cgcagacggc gcgcacggcc tcggcgaact cggcctcgtc
    14341 cggcgtgacg ccggcggcgc ccgaggccag cagcagcacc gtgtcgttgg tggacatgca
    14401 gccgtcggag tcgacgcggt cgaaggtggt gcgggtggcg gcgcgcagcg cgcggtcgag
    14461 cgcgggcgcc tccacgtcgg cgtcggtggt gagcacgacc agcatggtcg ccaggccggg
    14521 ggcgagcatg cccgcgccct tggccatgcc gccgacgcgc cagccctcgc cctcgacgac
    14581 ggcggtcttg tgcacggtgt cggtcgtcat gatggcgagc gcggcgcgct caccgccgtg
    14641 cgcggtcagc tcggcggcgg cggtgccgac cccggcgagc agcttctcgg tcggcagcct
    14701 ggtgccgatc aggccggtgg aggccacggc cacctcggcc gcgttcagtc cgagcacgtc
    14761 ggcggcgcgt tccgcggtgg cgtgggtgtc ctggaagccg agcgggcccg tgcaggcgtt
    14821 ggcgccgcct gagttgagca cgacggccgt cacgctgccg cccttgagca cctgctccga
    14881 ccacaggacg ggggcggcct tgacacggtt gctggtgaac acgccggccg ccgcggagcg
    14941 cggcccctgg ttgacgacga gggccaggtc gaggccgctg tccttgatgc ctgcggcgac
    15001 accggccgcg gtgaatccct gtgctgcggt cacgctcacg gcgccactcc gatcgtcgag
    15061 aggcccagtt cctccgggag gcccagggcg aggttcatgc tctgcaccgc gccgcccgcg
    15121 gtgcccttgg tgaggttgtc gacggcgctg atcgcgatga cgcgcccggc ggcctcgtcg
    15181 agggcgacct ggaccgcgac cgcgttggag ccggcgacgg cggccgtgct gggccactgc
    15241 ccctcgggca gcagccggac gaacggctcg gcggccagcg cccgttcgta ggtctcccgc
    15301 agccgggccg cggtgacgcc ggggcgcgcc gcggccgagc aggtggcgag gatgccgcgg
    15361 ggcatggggg cgagcatcgg ggtgaacgag acggacaccc gctcccccgc gacgccggag
    15421 aggttctgga tcatctcggg cgtgtggcgg tgcgtgccgc cgacgccgta ggggctcatg
    15481 gaccccatga cctcgctgcc gagcaggtgg gtcttgaggg agcgccccgc gcccgaggtg
    15541 ccgctcgcgg cgacgacgac ggcctcgggc tcgacgaggc gggcggcgta ggcggggaac
    15601 agggccaggg tcacggccgt cgggtagcag ccggggaccg cgacgcgccg ggcgcccttg
    15661 agcgcgtccc gcgcgccggg cagctcgggc agcccgtagg gccaggtccc cgcgtgcggg
    15721 gaaccgtaga accgttccca gtcggccgcg tcggacagcc tgaagtcggc gccgcagtcg
    15781 atgaccagcg tctcgtcccc gagctgcgcc gcgagggccc cggactgccc gtgcggcagg
    15841 gcgaggaaca cgacgtcgtg tccggccagg gactcggccg aggtcggcgc cagcacccgg
    15901 tcggccaacg gccccagctg cggctggagc gccccgaggg gctgtcccgc gttggcatga
    15961 ccggtcagcg ccccgatctc gacctcgggg tgtcccagga gcagccgcag gagttcccct
    16021 cccgcgtagc cactcgctcc cgccaccgca gctcgcacga ccatcgcctc ctcaagagtg
    16081 agtagcatga ctatacgcag cacggcagtt ttatgcaatg gtgcccgggt gggagacgcc
    16141 cggcgcggcc ggccggtcag gcgcgagcgc gccccgggga acgccccggg gcgggtgcgt
    16201 caccggggca ggaggacgcc gttgacggcg atgtccagca gcctgttcgc ccggccttcg
    16261 tcgtcatcgc gctgctcggc ggcgagcgac agcgcgctga ccagcgcgag caggtcctcg
    16321 acgcgcacac cggggcgcgc cgcgcccgcc cgctgcgcgc ggtccaggag ttctccggcc
    16381 gcggccgtga tcatcgcctg gcagtcgtcg ttccgcttca ggaggtcggc gtcaggaccg
    16441 tcgcggagca gcgaggacac gagtccgtgg ctggccgccg cgtagacgtt gaggtcgccg
    16501 agccaggcga cgagcgcgtc acccggctcc ctccggtcgg cgtgctcccc ggccttggcg
    16561 cagagcgcct cgacgcggtc gtggaagacc acgtcgagca gggagcgccg ggtggggaag
    16621 tgccggtgca gcgtcgcgga ccccaccccg gcacggcggg cgatctcctc cagcgaggcg
    16681 cgggcgccgt ccgcggcgaa cacctcctgg gccgcggcga cgatgcggtc gcggttgcgc
    16741 cgggcgtccg cgcgcatggg gcgccgccgg gcgggctcgg ccacgctggc ctcctgcggt
    16801 gtgcgaaatg gggcgcctct ccggttactg tagccgaagg aaagtggggt gccaccccac
    16861 ttttgccgag agtgagggga gcacgccatg cgtgccgtgc agtacgaccg tttcggcccg
    16921 cccgaggtgc tacgcgtcga cgaggtgccc gtcccgcggc cgggccgtgg agaggtgctc
    16981 gtcgaggtcc gcgccgccag cgtggacgcg ggggagatcg ccttccgctc gggccggctg
    17041 cggagggtca gccgggcggg attccctcgc cgcacgggcg gcgacttcac cggccgcgtc
    17101 tcggcggtcg ggcccggtgt ccggacctgg cgggccgggg acgcggtgtg gggactcatg
    17161 ccccacttcg ccttcggctc catggccgac tacgtctccg ttccccagga gcggctggcc
    17221 cgggcaccgg agaacctgag cctcctcgaa gccgccgcgc ttcccgtctc gggcaccacc
    17281 gcgctgaccg cgctgaccga caaggcgcgg ctcgcctccg gggaacggct cctggtccgc
    17341 ggtgcgaccg gaggcgtcgg cagcatcgcg gtccagttgg ggaaggccat cggcgcccac
    17401 gtcaccgccc tcgcctcggc cggcaacctg gcctgggtca ccgcgctcgg agccgacgag
    17461 gcacgcgact accgcaccac gcggcccgag gacctggagc ggttcgacgt gatcctcgat
    17521 gtcgtgggca ccgatctgcg cgcctatcgg gcgcggctga cgcgcagggg gcgcatggtg
    17581 gccctcgcct tcgaccccga ccgcttgctc acctccatcc tcgcgtccgg agcgcgggca
    17641 gccgtcgcac cgcggcggtt caagctcttc agcaacaacc cttcggcgga ccggatagcg
    17701 gaactgaccc gcctcgccga ggcggggagc gtccggccgg tggtcgactc ggtcttcccc
    17761 gcgaccggtg tcgcggaggc gcacagaaga ctcgaagccg gcggcgtccg ggggaagtac
    17821 ctgatcgaca tggaacgcgg acgcccgtag ccgcaccgga cgccggagcg cggcggcgcc
    17881 gccgccccgt cagcctccgc ttcccggccg gtccacgcgg tagaggtagt gggcccggtc
    17941 gtcgaccggg ttgtccggct ccagttcccc ggcgccgacc cggcgcagcc ccgcgcgctc
    18001 caaggcgcgc cacgaagcgc gattggccgc caccacggga acgaggacgc acggggcggc
    18061 cgggtgctcg gtccacgtcc gctcgacgac ggagcggagc atcgccgttc cgacgccccg
    18121 gccggtgtcc tcgggcgcgc cgatcaggta gtcgatggtc atcgcgccgt cgggcaccgg
    18181 gacgacggcc gccaactcgg ccaggtactc ggggtagtcg cacaggcgtg aacgctgcac
    18241 caggccgacc gggcggccgt cgaggaacgc gaggaggtcc tcggagggct cctccccccg
    18301 cgccgcgggg ccgaagtcgc gcgccaccgc cgccgccgag gtctcgtggt tccaccagcg
    18361 ccgcacgtgg gcctgctcca gccatgaccg cagcagcggg aagtcccgtt ccccgatccg
    18421 acgccacgtg aacaccacaa gcccccttct gcaacggccg cgcgcctgcg cacgccccct
    18481 ggcggaggtt acgcgcctgg gccggtcccg ggcgcacgcg ggtcccggcc gcaccgccgc
    18541 agcgggccgc accgcagcgg gccgccttgg gcacgcgcgg cgcgccgtgg cacgatcgcc
    18601 gggtgaccag cagaccgacc gaggcgcggc tgcgcgacct cgccgcactg cggcgcgtcc
    18661 gcgaccgcat cgaccgggag tacgcgcagc cgctggacgt ggaggccctc gcccgcggcg
    18721 cgcacatgtc ggccgggcac ctcagccgcg cgttccggcg cgcctacggc gagtcgccgt
    18781 acggctacct gatgacgcgg cgcatcgagc gcgcgatggc gctgctgcgg cgcggcgacc
    18841 tcagcgtcac cgaggtctgc ttcaccgtcg gctgctcctc gctcggcacc ttcagcaccc
    18901 ggttcaccga gctggtcggg atgccgccga gcgcctaccg gcgccgggcg gcccgggcga
    18961 cggcaggcat cccgtcgtgc gtggcgaagc aggtgacccg accggtcagg aatcgagaag
    19021 cgcaggtggc gggccgcgcc taacgtggcc gccatggacg tcaccattca cgccagtttc
    19081 ctcccgcacg acgacccgga cgcctcgctc gccttctacc gcgacctcct cggtttcgag
    19141 gtgcgcgacg acgtcggcta cgacggcatg cgctggatca ccgtcggtcc ccccggccgg
    19201 cccggcacct cgatcgtcct gcaaccgccc gcggccgacc cgggcatcac cgaggaggaa
    19261 cggcgcacca tcgtcgagat gatggccaag ggcacctacg ccggcatcct cctggcggcc
    19321 accgacctcg acggcgtctt cgaacgcctg cgggccgggg gcgccgagat cgtgcaggag
    19381 cccgccgagc agccgtacgg cgtgcgcgac tgcgccgtcc gcgaccccgc gggcaacctg
    19441 gtccgcctcc aggagccgcg ccgggacgcc cggtgacagc gaccgggccg cgcgcggacg
    19501 gcgaacggac ggccgcgccg cacgccgccg acagccacga cctgatccgg gtgcggggcg
    19561 cgcgcgagaa caacctgaag gacgtccgcg tcgacctccc caagcgccgg ctgaccgtgt
    19621 tcaccggtgt ctcggggtcg ggcaagagct cgctggtctt cggcacgatc gccgcggagt
    19681 cgcagcggat gatcaacgag acgtacagcg ccttcgtcca gggcttcatg ccggcgctcg
    19741 cgcgacccga cgccgacctg ctcgaagggc tgaccaccgc gatcatcgtc gaccaggagc
    19801 cgatgggagc caacgcccgc tccacggtcg gcacggccac cgacgccaac gccctgctcc
    19861 gcatcctgtt cagccggttc gggcagccgc acgtcggctc gcccaacgcg ttctccttca
    19921 acgtcgcctc gctgcgggcg agcggcgcga tcaccgtcga gcgcggtgac cgcgcgaccg
    19981 tgcgccggac gtacacggtc accgggggca tgtgcccggc ctgcgagggc atgggccggg
    20041 tgagcgacat cgacccggcc cagctctacg acgaggacaa gtccctcgcc gagggcgcca
    20101 tcaccgttcc cggctacaag gcggacggct ggtcggtgcg cgtcttcacc gcctcggggt
    20161 tcctcgacgc ggacaagccg atccgtgact actcggagac cgagctgcac gacttcctcc
    20221 accgcgagcc gaccaaggtg aggatcgaga acaccaacct gacctacgaa gggctcatcc
    20281 cccgggtcga gaagtcgttc ctcaccaaga gccgggaggc gttgcagccg cacatccggg
    20341 cgttcgtgga ccgcgccgtc acgttcaccg actgccccga ctgcggcggc acgcggctca
    20401 acgaggccgc ccgttcctcc cggatcgccg ggatcagcat cgccgacgcc tgcgcgatgc
    20461 agatcagcga cctggccgcg tgggtgcgcg gtctcgacga gccgtccgcc gctccgctgc
    20521 tcggcgcgct gcgcgacctg ctcggctcgc tggtggagat cgggctcggc tacctctcgc
    20581 tcgaccggcc ctccggcacg ctgtcgggcg gcgagtcgca gcgcgtgaag atggtccgcc
    20641 acctcggctc cagcctcacg gacgtgacct acgtgttcga cgagcccacc accggcctgc
    20701 acccgcacga catccagcgg atgaacgacc tgctgctgcg gctgcgcgac aagggcaaca
    20761 cggtgctggt cgtcgagcac aagcccgagg tcgtcgccat cgccgaccac gtcgtcgacc
    20821 tcggccccgg cgccggcacc tccggcggcg agatctgctt cgagggcacc ccggcgggac
    20881 tgcgggccag cggcaccctc accggccgcc acctcgacga ccggacggcg ctcaagaaga
    20941 cggtgcggac gcccaccggc gccctggaga tccggggcgc cgccgcgcac aacctgcgcg
    21001 acgtcgacgt ggacatcccg ctcggggtgc tcgtggtggt caccggcatc gcgggctcgg
    21061 gcaagagttc gctcgtgcgc gag
//
