LOCUS       NZ_CP071043            20825 bp    DNA     linear   CON 13-NOV-2023
DEFINITION  Bacillus subtilis isolate ELA2001105 chromosome.
ACCESSION   NZ_CP071043
VERSION     NZ_CP071043.1
KEYWORDS    RefSeq.
SOURCE      Bacillus subtilis
  ORGANISM  Bacillus subtilis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 4089676)
  AUTHORS   Tawari,N.R., Mane,S.P., Susanti,D., Volland,A. and Kumar,A.
  TITLE     Multi-omic analyses and microbiological characterizations of
            animal-origin Bacillus spp. as an alternative to antibiotic growth
            promoter to improve growth performance in broiler chicken
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4089676)
  AUTHORS   Tawari,N.R., Mane,S.P., Susanti,D., Volland,A. and Kumar,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-FEB-2021) Global Computational Sciences, Elanco Animal
            Health, 3rd Cross, Murugeshpallya, Bangalore, Karnataka 560017,
            India
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 28-JAN-2020
            Assembly Method                   :: HGAP v. 3
            Genome Coverage                   :: 126.45X
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/13/2023 05:04:14
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,241
            CDSs (total)                      :: 4,120
            Genes (coding)                    :: 4,006
            CDSs (with protein)               :: 4,006
            Genes (RNA)                       :: 121
            rRNAs                             :: 10, 10, 10 (5S, 16S, 23S)
            complete rRNAs                    :: 10, 10, 10 (5S, 16S, 23S)
            tRNAs                             :: 86
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 114
            CDSs (without protein)            :: 114
            Pseudo Genes (ambiguous residues) :: 0 of 114
            Pseudo Genes (frameshifted)       :: 79 of 114
            Pseudo Genes (incomplete)         :: 48 of 114
            Pseudo Genes (internal stop)      :: 19 of 114
            Pseudo Genes (multiple problems)  :: 26 of 114
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:27:42
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1115360
            Orig. end                         :: 1136185
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP071043.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotated at Elanco.
FEATURES             Location/Qualifiers
     region          1..20825
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20825
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20825
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10825](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10825
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(43..276)
                     /gene="gerPB"
                     /locus_tag="JS609_RS05725"
                     /old_locus_tag="JS609_01124"
     CDS             complement(43..276)
                     /codon_start=1
                     /gene="gerPB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388952.2"
                     /locus_tag="JS609_RS05725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JS609_01124"
                     /product="spore germination protein GerPB"
                     /protein_id="WP_003233090.1"
                     /transl_table=11
                     /translation="MNFYINQTIQINYLRLESISNSSILQIGSAGSIKSLSNLYNTGSY
                     VEPAPEVSGSGQPLQLQEPDTGSLVPLQPPGR"
     gene            complement(291..512)
                     /gene="gerPA"
                     /locus_tag="JS609_RS05730"
                     /old_locus_tag="JS609_01125"
     CDS             complement(291..512)
                     /codon_start=1
                     /gene="gerPA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388953.1"
                     /locus_tag="JS609_RS05730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JS609_01125"
                     /product="spore germination protein"
                     /protein_id="WP_003233088.1"
                     /transl_table=11
                     /translation="MPAIVGAFKINAIGTSGVVHIGDCITISPQAQVRTFAGAGSFNTG
                     DSLKVMNYQNATNVYDNDAVDQPIVANA"
     misc_feature    complement(526..542)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 23.92"
                     /tool="antismash"
     misc_feature    complement(925..939)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 23.18"
                     /tool="antismash"
     misc_feature    complement(926..941)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 21.96"
                     /tool="antismash"
     gene            complement(935..1105)
                     /gene="yisI"
                     /gene_synonym="pchI"
                     /locus_tag="JS609_RS05735"
                     /old_locus_tag="JS609_01126"
     CDS             complement(935..1105)
                     /codon_start=1
                     /gene="yisI"
                     /gene_synonym="pchI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388954.1"
                     /locus_tag="JS609_RS05735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JS609_01126"
                     /product="aspartyl-phosphate phosphatase YisI"
                     /protein_id="WP_003233086.1"
                     /transl_table=11
                     /translation="MNSKIEEMRITLIETAQKYGMNSKETIQCSQELDILLNTRIKEEM
                     IFGRYLENSRM"
     misc_feature    complement(1188..1208)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 24.84"
                     /tool="antismash"
     gene            complement(1251..2174)
                     /gene="yisJ"
                     /locus_tag="JS609_RS05740"
                     /old_locus_tag="JS609_01127"
     CDS             complement(1251..2174)
                     /codon_start=1
                     /gene="yisJ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388955.1"
                     /locus_tag="JS609_RS05740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JS609_01127"
                     /product="CotH kinase family protein"
                     /protein_id="WP_029726290.1"
                     /transl_table=11
                     /translation="MERVHLFFHREQLKRKGTAKGLFVTDRSVSPILLTQRDRAEKASY
                     EISWEKSLLGERTLFLNAEQDDPSLMRRRLAYCFFDQIGVPAPVASYSFLTINGQPEGI
                     YLNIKNHQPAGKRSYGVKTADPRVPLSLFNNDFSAFLHEFFILIRTAGDDELAERIKLY
                     LDVKLFFLWLIGNACTNQGFYYTFCLNESGRLYVSPMETRSLAVQEWYEEDPLLTKGKT
                     LSSRLLSIPAFRSQYHTLMKNVLKRSFTIERLSPLINEWHLDICQSAADDPFIKKSPFQ
                     IEKEQTNILREIEERQDFLQAHLARL"
     gene            2329..3234
                     /gene="mblK"
                     /locus_tag="JS609_RS05745"
                     /old_locus_tag="JS609_01128"
     CDS             2329..3234
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="mblK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388956.1"
                     /locus_tag="JS609_RS05745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JS609_01128"
                     /product="fumarylacetoacetate hydrolase family protein"
                     /protein_id="WP_003245441.1"
                     /transl_table=11
                     /translation="MKFATGELYNRMFVGLIIDDEKIMDLQKAEKKLFELETIPGSLIE
                     CIAEGDKFVAHARQLAEWAKKPNDELGSFMYSLSEVKLHAPIPKPSKNIICIGKNYRDH
                     AIEMGSEADIPEHPMVFTKSPVTVTGHGDIVKSHEEVTSQLDYEGELAVVIGKSGTRIS
                     KEDAYDHVFGYTIVNDITARDLQKRHKQFFIGKSLDTTCPMGPVLVHKSSIQEPERLKV
                     ETRVNGELRQSGSASDMIFSIPELIETLSKGMTLEAGDIIATGTPSGVGKGFTPPKFLR
                     SGDKIDITIDPIGTLSNQIG"
     misc_feature    3267..3281
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.4"
                     /tool="antismash"
     gene            3350..3706
                     /gene="yisL"
                     /locus_tag="JS609_RS05750"
                     /old_locus_tag="JS609_01129"
     CDS             3350..3706
                     /codon_start=1
                     /gene="yisL"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388957.1"
                     /locus_tag="JS609_RS05750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JS609_01129"
                     /product="YisL family protein"
                     /protein_id="WP_003244937.1"
                     /transl_table=11
                     /translation="MTHLHITTWVVALILLFVSYSLYSSGSAKGAKITHMILRLFYILI
                     ILTGAELFVRFANWNGEYAGKMILGIITIGLMEMLLIRKKKEKSTGGLWVGFVIVLLLT
                     VLLGLHLPIGFQLF"
     gene            3874..6558
                     /gene="wprA"
                     /locus_tag="JS609_RS05755"
                     /old_locus_tag="JS609_01130"
     CDS             3874..6558
                     /codon_start=1
                     /gene="wprA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388958.1"
                     /locus_tag="JS609_RS05755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JS609_01130"
                     /product="cell wall-associated protease WprA"
                     /protein_id="WP_038428763.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 5.2e-47, bitscore:
                     158.5, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRRKFSSVVAAVLIFALIFSLFSPGTKAAAAGAIDQAAALENGK
                     EQTGAMKEPEQVKWYKVTPGATDIQKNSHMALTVKSDSVLNVSVYPSKEKALKDETFEM
                     YRSFTAEDGKSEVIFPYAWSGPYYVKVEYLGEEEPEDGGTAEAAAEAKYTIGYKGTKKQ
                     PSDLEEEEACPVEMSVDQKKSGKGILDKLRAIRDEQLSQTAEGKELTSLYYKAAPFIVA
                     KLALNKTARNEIYQDLVTLKPLFDDVSENGASSSHKVTEKDQKAINRLYDKALQSVPSF
                     LKEEIKKQADRLNMKQLQGKTAGAILTENHIAAKSEVQTTKVIFKVKDNKSLSSVHNEM
                     KGFSASAQSKKDISNVKKAKKLFDNLYSFELPKDEKQNGAYTASAKRVKSAAATLSKMS
                     NVEFAEPVQEYKSLANDIQYPYQWPLKNNGENGGVKNADVKYEPANTLLSKRKLNDTLI
                     AVVDTGVDSTLADLKGKVRTDLGHNFVGRNNNAMDDQGHGTHVAGIIAAQSDNGYSMTG
                     LNAKAKIIPVKVLDSAGSGDTEQIALGIKYAADKGAKVINLSLGGGYSRVLEFALKYAA
                     DKNVLIAAASGNDGENALSYPASSKYVMSVGATNRMDMTADFSNYGKGLDISAPGSDIP
                     SLVPNGNVTYMSGTSMATPYAAAAAGLLFAQNPKLKRTEVEDMLKKTADDISFESVDGG
                     EEELYDDYGDPIEIPKTPGVDWHSGYGRLNVMKAVSAADLQLKVNKLESTQTAVRGNAK
                     EGTLIEVMNGKKKLGSAKAGKDNAFKVNIATQKQDQVLYVKATKGDAKTSYKVVVVKGK
                     PSGTPKVNAVKTKDTAVKGKANSKAMIRVKNKSKKVIASAKADAKGTFSVKIKKQKAGT
                     VLYVTAADTDKKESKEAKVVVEK"
     gene            complement(6589..7170)
                     /gene="yisN"
                     /locus_tag="JS609_RS05760"
                     /old_locus_tag="JS609_01131"
     CDS             complement(6589..7170)
                     /codon_start=1
                     /gene="yisN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388959.1"
                     /locus_tag="JS609_RS05760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JS609_01131"
                     /product="DUF2777 domain-containing protein"
                     /protein_id="WP_082201000.1"
                     /transl_table=11
                     /translation="MKKKETAWMKRKQLLYTEERKWEYGTILIEDGICLIENGEGDILL
                     ADSLQHSPIWVHHKGKWEQAGFQDKLVLACGAENISLSGGERIRYEKSVKRPLMALLDS
                     LDDETFLAFLQHLHSFGLSVFDCVFSYNKGVFSDTSAGQGVSFYHFSNDTAQCAMQHHY
                     SSEGTGDRFEWTASNGKRSIMYSAVQRGRK"
     misc_feature    complement(7153..7169)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 21.16"
                     /tool="antismash"
     gene            7316..9160
                     /gene="asnB"
                     /locus_tag="JS609_RS05765"
                     /old_locus_tag="JS609_01132"
     CDS             7316..9160
                     /EC_number="6.3.5.4"
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="asnB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388960.2"
                     /locus_tag="JS609_RS05765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JS609_01132"
                     /product="asparagine synthase (glutamine-hydrolyzing)"
                     /protein_id="WP_029726288.1"
                     /sec_met_domain="GATase_7 (E-value: 1.4e-46, bitscore:
                     155.4, seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 2e-99, bitscore:
                     331.5, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCGITGWVDFKKQLVQEKQTMDRMTDTLSKRGPDDSNVWGEHHVL
                     FGHKRLAVVDIEGGRQPMACTYKGDTYTIIYNGELYNTEDLRKELRARGHQFERTSDTE
                     VLLHSYIEWQEDCVDHLNGIFAFAVWDEKRNLLFAARDRLGVKPFFYTKEGSSFLFGSE
                     IKAILAHPDIKARVDRTGLSEIFGLGPSRTPGTGIFKGIKEIRPAHALTFSKDGLNIWR
                     YWNVESEKHTDSFDDTVANVRSLFQDAVTRQLVSDVPVCTFLSGGLDSSAITAIAAGHF
                     EKEGKAPLHTYSIDYEENDKFFQASAFQPNDDGPWIEKMTEAFGTTHHKCVISQKDLVD
                     HLEEAVLVKDLPGMADVDSSLLWFCREIKKDFVVSLSGECADEIFGGYPWFHTADVESG
                     FPWMRSTEERIKLLSDSWQKKLNLKEYVNAKYEETLAETPLLDGETGVDKARRQLFYLN
                     MLWFMTNLLDRKDRMSMGASLEVRVPFADHRLVEYVWNIPWEMKMHDNREKGILRKALE
                     GILPDDILYRKKSPYPKTHHPEYTKGVSEWLKTIRSQKDSVLHTLLDRKQLDQLLETEG
                     SSFKVPWFGQLMKGPQLIAHLAQIHTWFEAYRIDIDER"
     gene            complement(9290..9769)
                     /gene="yizA"
                     /locus_tag="JS609_RS05770"
                     /old_locus_tag="JS609_01133"
     CDS             complement(9290..9769)
                     /codon_start=1
                     /gene="yizA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_054576.1"
                     /locus_tag="JS609_RS05770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JS609_01133"
                     /product="DinB family protein"
                     /protein_id="WP_080479538.1"
                     /transl_table=11
                     /translation="MIKFFEYNWQVRDQWFTWCHQLTTEELLKNRLGGVENILYTLFHI
                     IDVEYSWIRAIQGKEDIAVQFADYQTLNKVKSLSNTFRTEIIDVLQTHSDQIKDELVSV
                     PWETSVLYTRDEILHHIIAHEIHHIGQLSVWARELKLSPVSASFIGRTLKPIHSY"
     misc_feature    9748..9762
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.73"
                     /tool="antismash"
     gene            10001..10825
                     /gene="farP"
                     /locus_tag="JS609_RS05775"
                     /old_locus_tag="JS609_01134"
     CDS             10001..10825
                     /codon_start=1
                     /gene="farP"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388961.1"
                     /locus_tag="JS609_RS05775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JS609_01134"
                     /product="farnesyl diphosphate phosphatase"
                     /protein_id="WP_010886471.1"
                     /sec_met_domain="phytoene_synt (E-value: 1.3e-30, bitscore:
                     104.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 2e-34,
                     bitscore: 117.1, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIHRSEKMKEIKEAYQQCGQIVGEYAPACFKALSYLPLKQRQASW
                     AVLSFCHTAASADEKVLPAFEAKADHVYQRTNNGKQHLWKAFDHAYRTFTLESEPFREF
                     IAAQKEDAKPYDDLDELLMYAYRTGGAAGLMLLPILTRRKQDQLKQAAVSLGLAIQLVR
                     FLSDLGTDQQKNRIPRQVMQQFGYTEADLQKGTVNKAFTMTWEYIAFEAEAYLEECQDA
                     LPLFPQYSQKTVKAALHLHRAVLEKIRAKQHDVFQYHFALTETEVKQILSDI"
     gene            complement(10855..12222)
                     /gene="yisQ"
                     /locus_tag="JS609_RS05780"
                     /old_locus_tag="JS609_01135"
     CDS             complement(10855..12222)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0042910 - xenobiotic transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006855 - xenobiotic transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /gene="yisQ"
                     /gene_functions="transport (smcogs) SMCOG1086: MATE efflux
                     family protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388962.1"
                     /locus_tag="JS609_RS05780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JS609_01135"
                     /product="MATE family efflux transporter"
                     /protein_id="WP_225721946.1"
                     /transl_table=11
                     /translation="MKQAVFKSTALKKPADKTFSLFSLTWPIFIEVSLYMFMGNADTLM
                     LSQYSDNSVAAVGVSNQILNLIIVMFSFIATGTTVIISQFLGSRQKKEAMEVAYVSIGA
                     NFFISLAISAVVFFAAVPLLHMMGLSDALMPDAKVFLQVVGGLSFIQALIMTFSAILKS
                     YGYTKDTMFVTIGMNILNIAGNFVVIFGLFGFPVLGVTGVAMSTSIARVIGLIAMIVIV
                     NKRIQLKMSLKKVFHMHKEHLRKLLKIGIPSAGEQLSYNLSQMIVTYFIAIMGAQALTT
                     KVYTQNITMFILLFGTAISQGTQILIGRYIGGKQFDAAYERCMKSLYWALGIAAATSVL
                     MTIFSKDLIGLFTQSPDIIATASLLIAMTIILEPGRSFNVIIINSLRAAGDAKFPVYMA
                     MISMWGIGLPLAYLFGIHLGFGLAGIWISFIADEWVRGILMYRRWRSRIWIQKGMA"
     gene            12346..13209
                     /gene="yisR"
                     /locus_tag="JS609_RS05785"
                     /old_locus_tag="JS609_01136"
     CDS             12346..13209
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="yisR"
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388963.1"
                     /locus_tag="JS609_RS05785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JS609_01136"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_003245539.1"
                     /transl_table=11
                     /translation="MPRILFTVPPFPVFIAAGEGVFKKGETHVKRVFSVFDLIYVKQGT
                     LYITENETSFSVEGGEYILLSPGLEHYGTKGSDEATSYYWLHFDEHRYEFTAKGGSNWS
                     ELQQEKGSFEEPARYGLALPRKGKVQRPQFMAQQFEKLIDYSAENSDLPLRKQILFEEL
                     MLHLQKEAFQIPSAKERVAWEAARYLQEHYKEKTTIKDLSLALHYHQDYVSRCMQQVLG
                     VTPAQYTNRVRMTEAKRLLSSTNDKMGVIAETVGMEDPTYFSKLFKQIEGISPIEYRKI
                     VSRKVQ"
     gene            13227..14240
                     /gene="degA"
                     /gene_synonym="iolQ"
                     /locus_tag="JS609_RS05790"
                     /old_locus_tag="JS609_01137"
     CDS             13227..14240
                     /codon_start=1
                     /gene="degA"
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /gene_synonym="iolQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388964.1"
                     /locus_tag="JS609_RS05790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JS609_01137"
                     /product="transcriptional regulator DegA"
                     /protein_id="WP_003245813.1"
                     /transl_table=11
                     /translation="MKTTIYDVAKAAGVSITTVSRVINNTGRISDKTRQKVMNVMNEMA
                     YTPNVHAAALTGKRTNMIALVAPDISNPFYGELAKSIEERADELGFQMLICSTDYDPKK
                     ETKYFSVLKQKKVDGIIFATGIESHDSMSALEEIASEQIPIAMISQDKPLLPMDIVVID
                     DVRGGYEAAKHLLSLGHTNIACIIGDGSTTGEKNRIKGFRQAMEEAGVPIDESLIIQTR
                     FSLESGKEEAGKLLDRNAPTAIFAFNDVLACAAIQAARIRGIKVPDDLSIIGFDNTILA
                     EMAAPPLTTVAQPIKEMGRSVIELLAEAIEGKRKAKQKIVLPPELVVRHSTSPLNT"
     misc_feature    14377..14386
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.31"
                     /tool="antismash"
     misc_feature    complement(14397..14408)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.99"
                     /tool="antismash"
     gene            14449..15477
                     /gene="iolX"
                     /gene_synonym="yisS"
                     /locus_tag="JS609_RS05795"
                     /old_locus_tag="JS609_01138"
     CDS             14449..15477
                     /codon_start=1
                     /gene="iolX"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="yisS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388965.1"
                     /locus_tag="JS609_RS05795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JS609_01138"
                     /product="scyllo-inositol 2-dehydrogenase"
                     /protein_id="WP_225721947.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 7.5e-33, bitscore:
                     111.7, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 1.7e-27,
                     bitscore: 93.8, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHQVRCAVLGLGRLGYYHAKNLVTSVPGAKLVCVGDPLKGRAEQ
                     VARELGIEKWSEDPYEVLEDTGIDAVIIVTPTSTHGDMIIKAAENGKQIFVEKPLTLSL
                     EESRAVSEKVQETGVICQVGFMRRFDPAYADAKRRIDAGEIGKPIYYKGFTRDQGAPPA
                     EFIKHSGGIFIDCSIHDYDIARYLLGAEITSVSGHGRILNNPFMEQYGDVDQALTYIEF
                     DSGAAGDVEASRTSPYGHDIRAEVIGTEGSIFIGTLRHQHVTILSAKGSSFDIIPDFQT
                     RFHEAYCLELQHFAECVRNGKTPIVTDIDATINLEVGIAATNSFRIGRPVQLDVKHAYT
                     GM"
     gene            complement(15530..16039)
                     /gene="yisT"
                     /locus_tag="JS609_RS05800"
                     /old_locus_tag="JS609_01139"
     CDS             complement(15530..16039)
                     /codon_start=1
                     /gene="yisT"
                     /gene_functions="other (smcogs) SMCOG1250: DinB"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388966.2"
                     /locus_tag="JS609_RS05800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JS609_01139"
                     /product="DinB family protein"
                     /protein_id="WP_038428145.1"
                     /transl_table=11
                     /translation="MTDAKQFYDYHSWANKKIFTHIENLPEETAYQEVKSVFPSVSDVL
                     LHMCRADYIWLNVLSGVAYQEIIDSAGKLESAQGNMAAIKQHAAELESQYHDFFSRQTD
                     LEQTFTMQHPKLGTLESTYADTILHVVNHGTYHRGNVTAMLRQLGHSGIPTDYMYYLYE
                     KRESKG"
     gene            complement(16089..16750)
                     /gene="yisU"
                     /locus_tag="JS609_RS05805"
                     /old_locus_tag="JS609_01140"
                     /pseudo=""
     CDS             complement(16089..16750)
                     /codon_start=1
                     /gene="yisU"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388967.1"
                     /locus_tag="JS609_RS05805"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="JS609_01140"
                     /product="LysE/ArgO family amino acid transporter"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTISLMIEKNVKGAFSA"
     misc_feature    16716..16731
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 25.99"
                     /tool="antismash"
     gene            16817..18271
                     /gene="yisV"
                     /locus_tag="JS609_RS05810"
                     /old_locus_tag="JS609_01141"
     CDS             16817..18271
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (121-462). E-value:
                     8.5e-36. Score: 115.7. Matches aSDomain:
                     nrpspksdomains_JS609_RS05810_Aminotran_1_2.1"
                     /codon_start=1
                     /gene="yisV"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388968.2"
                     /locus_tag="JS609_RS05810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JS609_01141"
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="WP_225721948.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 5.6e-34, bitscore:
                     115.8, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLSQWQPSRKSDVPLHRQIEQYMKDKILHGEWAVGTKIPSQRTL
                     AGMFQVNRSTVTAAIDELTSQGLLEGRRGGGTKVVNSTWSVLAAEPPLDWSDYVRSGIH
                     RANSSIIQAINQNEPRADIIRLGTGELSPDLVPADTIGRMFQQINPGALSLGYEQPKGN
                     RQLREAVADHLKGKKIHVSPSAILIVSGALQALQLISIGLLKRDSVILTEKPSYLQSLH
                     VFQSAGMRLRGLPMDDEGVKAGLVSSNRKQYGGQLLYTIPSFHNPTGTVMSEQRRKEII
                     SLSKKEQLPIIEDDAYGDLWFEEKPPQPLKAMDHEGNILYLGTFSKTVSPGLRIGWLAG
                     PEPVIERLADIKMQTDYGSSGLSQWAAAEWLSQGYYEEHLTWVRRKLKERRDAAVHFLE
                     RYAGDIATWRIPAGGFYIWVTFHKNLPVSRFFYGLLKRQVLVNPGYIYDGEDRNSIRLS
                     YSYASLGDLETGIKAAAETARCLMMS"
     aSDomain        17180..18202
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JS609_RS05810_Aminotran_1_2.1"
                     /evalue="8.50E-36"
                     /label="JS609_RS05810_Aminotran_1_2.1"
                     /locus_tag="JS609_RS05810"
                     /protein_end="462"
                     /protein_start="121"
                     /score="115.7"
                     /tool="antismash"
                     /translation="DIIRLGTGELSPDLVPADTIGRMFQQINPGALSLGYEQPKGNRQL
                     REAVADHLKGKKIHVSPSAILIVSGALQALQLISIGLLKRDSVILTEKPSYLQSLHVFQ
                     SAGMRLRGLPMDDEGVKAGLVSSNRKQYGGQLLYTIPSFHNPTGTVMSEQRRKEIISLS
                     KKEQLPIIEDDAYGDLWFEEKPPQPLKAMDHEGNILYLGTFSKTVSPGLRIGWLAGPEP
                     VIERLADIKMQTDYGSSGLSQWAAAEWLSQGYYEEHLTWVRRKLKERRDAAVHFLERYA
                     GDIATWRIPAGGFYIWVTFHKNLPVSRFFYGLLKRQVLVNPGYIYDGEDRNSIRLSYSY
                     A"
     gene            complement(18279..18917)
                     /gene="yisX"
                     /locus_tag="JS609_RS05815"
                     /old_locus_tag="JS609_01142"
     CDS             complement(18279..18917)
                     /codon_start=1
                     /gene="yisX"
                     /gene_functions="other (smcogs) SMCOG1286: Pentapeptide
                     repeat protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388970.1"
                     /locus_tag="JS609_RS05815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JS609_01142"
                     /product="pentapeptide repeat-containing protein"
                     /protein_id="WP_014479410.1"
                     /transl_table=11
                     /translation="MNKIAIQKPNIPENLQTADFHDAVTQDDVISMHLFEDCTICGEDI
                     ERLCVEKTVFRNVVFIDVSFRHIELTDVIFEKCDLSNADFSGAVIHRTSVKQSKMVGMN
                     VAEATLRNVSFEECHGHFSSFSYSNMKQVRFDHCALMQSECSNTVLQQTHFDGCELEGA
                     SFTGTSLQNMDISTCRFEQLHVSLDKLKGCKIAPEHAIAFARALGAVIV"
     gene            19123..19929
                     /gene="yisY"
                     /locus_tag="JS609_RS05820"
                     /old_locus_tag="JS609_01143"
     CDS             19123..19929
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (22-254). E-value:
                     5.5e-35. Score: 113.1. Matches aSDomain:
                     nrpspksdomains_JS609_RS05820_Abhydrolase_1.1"
                     /codon_start=1
                     /gene="yisY"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388971.1"
                     /locus_tag="JS609_RS05820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JS609_01143"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_003245141.1"
                     /sec_met_domain="PF00561 (E-value: 2.2e-27, bitscore: 94.2,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 5.6e-18, bitscore:
                     64.3, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGHYIKTEEHVTLFVEDIGHGRPIIFLHGWPLNHKMFEYQMNELP
                     KRGFRFIGVDLRGYGQSDRPWEGYDYDTMADDVKAVIYTLQLENAILAGFSMGGAIAIR
                     YMARHEGADVDKLILLSAAAPAFTKRPGYPYGMRKQDIDDMIELFKADRPKTLADLGKQ
                     FFEKKVSPELRQWFLNLMLEASSYGTIHSGIALRDEDLRKELAAIKVPTLILHGRKDRI
                     APFDFAKELKRGIKQSELVPFANSGHGAFYEEKEKINSLIAQFSNS"
     aSDomain        19189..19884
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JS609_RS05820_Abhydrolase_1.1"
                     /evalue="5.50E-35"
                     /label="JS609_RS05820_Abhydrolase_1.1"
                     /locus_tag="JS609_RS05820"
                     /protein_end="254"
                     /protein_start="22"
                     /score="113.1"
                     /tool="antismash"
                     /translation="PIIFLHGWPLNHKMFEYQMNELPKRGFRFIGVDLRGYGQSDRPWE
                     GYDYDTMADDVKAVIYTLQLENAILAGFSMGGAIAIRYMARHEGADVDKLILLSAAAPA
                     FTKRPGYPYGMRKQDIDDMIELFKADRPKTLADLGKQFFEKKVSPELRQWFLNLMLEAS
                     SYGTIHSGIALRDEDLRKELAAIKVPTLILHGRKDRIAPFDFAKELKRGIKQSELVPFA
                     NSGHGAFYEE"
     gene            complement(19957..20556)
                     /gene="cysC"
                     /locus_tag="JS609_RS05825"
                     /old_locus_tag="JS609_01144"
     CDS             complement(19957..20556)
                     /EC_number="2.7.1.25"
                     /GO_function="GO:0004020 - adenylylsulfate kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006790 - sulfur compound metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cysC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388972.1"
                     /locus_tag="JS609_RS05825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JS609_01144"
                     /product="adenylyl-sulfate kinase"
                     /protein_id="WP_003245829.1"
                     /transl_table=11
                     /translation="MTHNPNIIWHPAAISKSDRQSLNGHKSCVLWFTGLSGSGKSVLAN
                     AVDEKLYRKGIQSYVLDGDNIRHGLNKDLGFQTGDRIENIRRIGEVAKLFVDSGQMILT
                     AFISPFREDRDMVRALFPKGEFFEIYVKCPLHVCEQRDPKGLYKKARNGEIKHFTGIDS
                     PYEAPLSPDFIIESDQTSISDGADLIINALQNRGII"
     misc_feature    complement(20550..20560)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     misc_feature    complement(20779..20788)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
ORIGIN
        1 gaaacagatt gatcatacat gttcttcacc tctttcatat gattaacggc caggaggctg
       61 gagcgggacc aatgaacctg tgtcgggctc ctgcagctgg agcggttgcc ctgagccaga
      121 aacttctggt gccggttcta catagcttcc tgtattatac aaatttgaca gtgacttgat
      181 tgatccggcg ctcccgattt gcagaatgga ggagttgctg attgattcca gccggagata
      241 gttgatttga atggtttgat taatatagaa gttcatgagc ctcactcctt ttacgcattg
      301 gccacgatcg gctgatcaac cgcatcattg tcatacacat tcgtcgcgtt ttgataattc
      361 atcaccttga ggctgtcgcc ggtattaaag ctgccagcac cggcaaacgt tctgacctga
      421 gcctgaggag aaatcgtaat gcagtccccg atgtgaacga ctccgctcgt accaatcgca
      481 ttaattttaa acgctccgac aatggccggc atacgagcac atcctttgtt gaaaaattaa
      541 aaaaagacag gtaaagtgaa atgacaattc tgatttcaat tgggctattc acgatagctt
      601 atgacaaacg cacatatgtg tgagagaaat ttaaagggga catatcggct ctttatgaaa
      661 gcgctttatt ttttcgggcc gttatgttta aacatggcaa aagaggatgt tgggtataaa
      721 ttgagcggaa atgcggcgaa ggatgccgct atccgcctat ggtgattttt gtttatttct
      781 ttggtgtttt tgcgtgtaga atgctttttg gagtatgtcg tgctgcggta ttcgattttt
      841 gggcgggcac attctcgccc tgaggtatat cccagaagtg ctgagcaaaa agcggagtta
      901 catgtggtgt attctaattg ttatagaaaa tgatttacat acgggagttt tcaagatatc
      961 tcccaaaaat catttcttct ttaatccggg tattcagcag gatatccagc tcttggctgc
     1021 attgaatcgt ttcttttgaa ttcatgccat atttttgtgc ggtttcaatt agtgtgatcc
     1081 tcatttcttc aattttactg ttcattacgc tatctccaat tctagatttt attttgatat
     1141 aaatacagga tatcgttagt ataacctatt ttggctcaaa aggttgcctt tcgtcaattt
     1201 gactaaaaaa gcgacaattt ttgctgcggc cttttttaat ggagaaagga ctaaagtctt
     1261 gctaagtgtg cttgcaaaaa gtcctgccgt tcctcaattt ctctaagtat gttggtctgc
     1321 tccttttcga tttgaaaggg gctttttttg ataaaaggat catcagcagc actttgacaa
     1381 atgtcaaggt gccattcgtt gatgagagga gataatcgtt caatagtaaa cgaccgcttc
     1441 agcacgtttt tcattaaggt gtgatattgc gacctgaagg cgggaatgga tagaagcctt
     1501 gacgaaagcg tctttccttt tgtcagaagc gggtcttctt cataccattc ttgtacggca
     1561 agcgatcttg tctccatcgg ggaaacgtaa agccgaccgg attcgtttaa acaaaatgtg
     1621 tagtaaaagc cttgattggt gcaggcgttg ccgatcagcc acaaaaaaaa cagcttgaca
     1681 tccagataca atttaatcct ttcagccaat tcgtcatctc cggctgtgcg gatcagtatg
     1741 aaaaattcat gtaagaatgc cgagaaatca ttgttaaaaa gggacaatgg aacccttgga
     1801 tcggccgtct tcactccgta actcctttta ccggctggct gatggttctt gatgttcaaa
     1861 taaatgcctt caggctggcc attgatggtc agaaagctgt acgaggcaac gggagcaggt
     1921 acgccgatct ggtcaaaaaa acaataggcg agtctgcgcc gcatcaggga cggatcatcc
     1981 tgttctgcat tcaaaaaaag tgtcctttca ccaagcagag acttttccca gctgatttca
     2041 taggatgcct tttccgctct gtcacgctgt gtgagaagaa tgggagaaac agatcgatct
     2101 gttacgaaaa gccccttggc tgtacctttc cttttcagct gctcccgatg aaaaaataaa
     2161 tgcacgcgct ccatattctt tcctccttct caaaacgaca tttgtatgat atgtagagca
     2221 agcccgtcct gaaacgaaat gaaaacggaa aggagaaaaa gggatttcag cattcgacag
     2281 agaatacatg aaggagcatt ctgatttaaa agatgatgga ggaataacat gaaatttgcg
     2341 acaggggaac tttacaaccg aatgtttgtc ggcctgatca ttgacgatga gaaaattatg
     2401 gatttgcaaa aggctgaaaa aaaactgttt gaacttgaga cgattccggg atcgctgatt
     2461 gaatgtatcg cagaagggga taaattcgtt gcgcatgcaa ggcagctggc cgagtgggca
     2521 aagaaaccga atgatgagct gggatcattt atgtattcat tatctgaggt gaagctccat
     2581 gcacccattc cgaagccatc aaaaaatatc atctgcatcg gcaaaaacta ccgggatcac
     2641 gcgattgaaa tggggagcga ggctgatatt ccggagcatc cgatggtatt tacaaaatcg
     2701 ccggtaacgg ttacggggca tggtgatatc gtaaagagcc atgaagaggt tacctcccag
     2761 cttgattatg agggagaact tgctgtcgtg atcggaaaaa gcgggacccg catttcaaaa
     2821 gaagatgcat atgaccatgt tttcggatat acgattgtga atgatatcac ggcgcgtgat
     2881 ctgcaaaaaa ggcataagca gttttttatc ggaaaaagct tggatacgac atgtccgatg
     2941 gggcccgtgc ttgtacataa atcatctatt caggagccag agcgcctcaa ggttgaaaca
     3001 agagtcaacg gcgagctgcg tcaatccggt tcggcaagcg atatgatctt ttccattccg
     3061 gaattaattg aaaccctctc aaaggggatg acgcttgaag cgggcgacat tattgccacc
     3121 ggtacgccat ctggtgtcgg caaggggttt actcctccaa aattcttgcg gtcaggtgac
     3181 aaaattgata ttacaattga tccgatcgga acgctgtcaa accaaattgg ctgaataaaa
     3241 ctggagggcg gacccggacc cgcccgtttt ttctgataat catctttgtg gcagaggaca
     3301 agttcatggt actataagtg gggtaattta tctgataggg ggaacatata tgacacacct
     3361 acatattacg acatgggtgg tagcgctgat tctgcttttc gtcagctact cgctgtattc
     3421 gtcaggaagt gcaaagggcg caaaaatcac tcatatgatt ctgcggttat tctatatcct
     3481 tattattttg acaggagctg agctgtttgt ccgtttcgcc aactggaacg gagaatacgc
     3541 cggcaaaatg attctgggca ttatcaccat cggcctgatg gaaatgctgc tcatccgcaa
     3601 gaaaaaagaa aaatcaacag gaggcctgtg ggtcggcttc gtcattgtcc ttttgctgac
     3661 agtgctgctc ggtctgcatt tgccaattgg ttttcaattg ttttaataga aaaacctatg
     3721 aacccggctc tttgatagag ttgggttttt ttatatttat cccctcatat tccaaatcat
     3781 ttaaaataac cttaaaattc cctgtaagcg gtatctcgtc ctatgaaatt atgatacctt
     3841 caaggagatt cattattttg caggagggat aacatgaaac gcagaaaatt cagctcggtt
     3901 gtggcggcag tgcttatttt tgcactgatt ttcagccttt tttctccggg aaccaaagct
     3961 gcagcggccg gcgcgatcga tcaggcggct gctctggaaa acggcaaaga gcagacaggc
     4021 gccatgaagg agccggaaca ggtgaaatgg tacaaagtga ccccgggagc aacggatatt
     4081 cagaaaaact cacatatggc actgaccgta aagagtgatt cagtactgaa tgtatctgta
     4141 tatccaagta aggaaaaagc gcttaaagat gagacgtttg agatgtaccg ttctttcaca
     4201 gcggaggatg gaaaaagcga agtcattttt ccatacgcgt ggagcggccc ttactatgta
     4261 aaagttgaat acctcggaga agaagagcca gaggacggcg gaacggcaga agcagctgca
     4321 gaagccaagt atacgattgg gtataaaggc accaaaaaac agccgtcaga tttagaagag
     4381 gaagaagctt gtccggttga aatgagtgtc gatcagaaga aatcaggaaa aggcatcctg
     4441 gataagctga gagcgattcg tgatgagcag ctgagccaaa cagcagaagg caaagaactg
     4501 acaagccttt attacaaagc agcaccgttt atcgttgcaa agctcgcact caataaaaca
     4561 gcaagaaatg aaatctatca ggatcttgtg acattaaagc cgttatttga cgatgtgtca
     4621 gaaaacggag catcatcttc gcataaggtc actgaaaagg atcaaaaagc aatcaaccgg
     4681 ctatatgata aagctttaca atcagtcccg tcattcctta aagaggagat aaagaaacaa
     4741 gcggaccgac taaatatgaa gcagctgcaa ggcaaaacag ccggagccat tttaacagaa
     4801 aaccatattg cagcaaaaag tgaagttcag acaacaaagg ttattttcaa ggtgaaggac
     4861 aataaaagcc tctcatccgt acataatgaa atgaagggct tttctgcaag cgcgcaatcg
     4921 aaaaaagaca tatccaatgt gaaaaaggca aagaaactgt ttgacaatct gtattcattt
     4981 gaacttccga aagatgagaa acagaacggc gcatatacgg caagcgccaa aagggtcaaa
     5041 agcgctgctg cgacactatc caagatgtcc aatgtagagt ttgcggaacc cgtgcaggaa
     5101 tacaaaagcc tggcaaacga cattcagtac ccttatcaat ggccgcttaa aaacaacggt
     5161 gaaaacgggg gtgtcaaaaa tgcggatgtg aaatatgagc ctgccaacac attgctgtcc
     5221 aaacgcaagc ttaacgatac actcattgca gtagtagaca caggcgtaga cagcacgctt
     5281 gctgatttaa aaggaaaagt aagaacagat ctcggacaca attttgtcgg acggaataac
     5341 aatgcaatgg atgatcaggg gcatgggacg catgtcgcag gcattattgc ggcccaaagc
     5401 gataacggct attcaatgac tggattgaat gccaaagcaa aaatcatccc ggtaaaagtg
     5461 cttgattccg caggttccgg agatactgaa caaattgctc tcggcatcaa atatgctgct
     5521 gacaaaggag caaaggtgat taatttaagt ttaggcggag gctacagccg cgtgcttgaa
     5581 tttgctttga agtacgcagc tgacaaaaat gtcttgattg ccgcagccag cgggaatgat
     5641 ggagaaaatg ccttatctta tccagcatct tctaaatatg tgatgtcagt cggcgcaacg
     5701 aaccgcatgg atatgaccgc tgatttctct aactatggaa aaggtctgga catctctgct
     5761 ccagggtctg atatcccgag cttagtaccg aacggaaatg tcacgtacat gagcggaacg
     5821 tctatggcga cgccgtatgc tgccgctgct gcaggattgc tgtttgctca aaatcctaag
     5881 ctgaaaagaa cagaagttga ggatatgttg aaaaagacgg cagatgacat ttcctttgaa
     5941 agtgtcgatg gcggagaaga agagttgtat gacgattatg gcgatccgat tgaaattccg
     6001 aagacacctg gtgtagactg gcattcaggc tacgggcggc tgaatgtcat gaaggctgtc
     6061 agcgcagctg atttacagct taaggtcaac aagctggaaa gcactcaaac agctgtcaga
     6121 ggaaacgcga aggaaggcac acttatcgag gtgatgaacg gcaaaaagaa actcggcagc
     6181 gccaaagccg gaaaagacaa tgcgttcaag gtcaatatcg cgactcaaaa acaggatcaa
     6241 gtactgtatg tgaaagcaac aaaaggcgat gcgaaaacat cgtataaagt tgtcgtcgtc
     6301 aaaggaaaac cttccggcac accgaaagta aacgcggtga aaacgaagga tacggcagta
     6361 aaagggaagg caaacagcaa agcgatgatc agagtgaaaa acaaatcaaa gaaagtcatt
     6421 gcttctgcca aagctgacgc aaaaggaacg ttttcggtga aaatcaaaaa acaaaaagcc
     6481 ggaacggtgc tgtacgtcac ggctgcggat acagataaaa aagaaagcaa ggaagcaaaa
     6541 gtggttgttg aaaagtaacc aaaaagcggt gctcgatgca ccgctttttt atttgcgccc
     6601 ccgttggact gctgaataca taatggatcg ctttccgttt gaagccgtcc attcaaaacg
     6661 gtctcctgtc ccttcgctgc tgtagtgatg ctgcatcgcg cattgtgcgg tgtcatttga
     6721 aaagtgataa aaggacacac cctgccccgc cgaagtatcc gaaaagactc ctttattata
     6781 agaaaagacg caatcgaata ccgataagcc gaagctgtgc aagtgctgca gaaatgcgag
     6841 aaaggtttcg tcgtcaagcg aatccaaaag cgccatgaga ggccgcttga ctgatttctc
     6901 atagcggatg cgttctccgc cggaaaggga gatgttttct gcaccgcatg ccaaaaccaa
     6961 cttgtcctga aagccggctt gctcccactt tcctttatga tggacccaga ttgggctgtg
     7021 ttggagactg tccgccagca gtatatcgcc ttcaccgttt tcgattaagc agatgccgtc
     7081 ttcaatgagg atggtgccgt attcccactt tcgttcctct gtatataaca attgtttccg
     7141 tttcatccat gctgtctcct ttttcttcat tcctctcttt tctttccaat tcaagcctgt
     7201 cccatacaac tcttttatgg acaaatcaac tatctgccta tagatgcata aacttactaa
     7261 ggtgctgaaa gaaacgaaat tgttacgaaa gaaacgggat tggagctgat gtcacatgtg
     7321 tggaattacg ggttgggtcg attttaaaaa gcagctcgtc caggaaaaac aaacgatgga
     7381 cagaatgaca gacactcttt ccaaacgagg gcctgatgat tcaaacgttt ggggggagca
     7441 ccatgtttta ttcggacata aaagacttgc ggttgttgat attgaaggcg gacgccagcc
     7501 gatggcgtgt acctataaag gggatacgta caccattatt tacaatggcg agctttataa
     7561 cacggaagat ttgcgcaaag aattgcgggc gcggggccat caattcgagc gtacgtcaga
     7621 taccgaggtg cttctgcaca gctacatcga gtggcaggaa gactgtgtcg accatctcaa
     7681 tggcatattc gctttcgctg tgtgggatga aaagcgtaat ctgctgtttg ccgcgagaga
     7741 ccgtctcggc gtaaagccgt ttttttacac gaaggaaggc tcttcatttc tcttcggttc
     7801 ggaaatcaaa gcaatcctcg cgcaccctga tataaaagcg agagtggaca gaacgggact
     7861 ttctgaaatt ttcggtcttg gaccgtccag aaccccgggc actggcatat ttaaaggcat
     7921 aaaagaaatc cgcccggctc acgcgctgac attttccaaa gacggactta atatttggcg
     7981 ttattggaat gttgaaagcg aaaaacatac ggacagtttt gatgacacgg ttgccaatgt
     8041 cagatcgtta tttcaggacg cggtgacgcg gcagcttgtg tcggatgtgc cggtttgcac
     8101 attcctatca ggcggtctgg actcaagcgc aattacagcg attgcggcgg gccattttga
     8161 aaaggaagga aaagcaccgc ttcatactta ttcgattgat tacgaagaga acgataaatt
     8221 ttttcaagca agcgcttttc agccgaatga tgacggacca tggattgaaa aaatgacaga
     8281 ggctttcggc acaacgcacc acaaatgcgt catcagccaa aaagatctcg ttgatcattt
     8341 ggaggaagct gtactggtca aagacttgcc gggaatggcg gatgtcgact catccctgct
     8401 gtggttttgc cgggaaatca aaaaggactt tgtcgtcagc ctatcgggag agtgcgcgga
     8461 tgagattttc ggcgggtacc cgtggttcca tacggcagat gttgagtctg gctttccatg
     8521 gatgagatca acggaggagc ggatcaagct gctttctgac tcatggcaga aaaaattgaa
     8581 tctgaaagaa tacgtaaatg ccaaatatga agaaaccttg gcagaaacgc cattattaga
     8641 cggagaaacg ggtgtggata aagcaagaag acagctgttc tatttaaata tgctttggtt
     8701 tatgacgaac cttttggatc ggaaggatcg catgagcatg ggggcgagcc tggaagtgcg
     8761 ggtgccgttc gccgatcacc ggcttgtgga atatgtttgg aatattccgt gggaaatgaa
     8821 aatgcatgat aatcgggaaa aaggcatttt acgcaaagcg cttgaaggta ttttgcctga
     8881 tgacattctg tatcgcaaaa aaagcccgta tccgaaaaca catcatccgg aatatacaaa
     8941 aggcgtcagc gaatggctga aaacgatcag aagccaaaag gactccgtgc tccatacctt
     9001 gctggacaga aaacaattag atcagctttt agaaacggaa ggctcctctt tcaaggtgcc
     9061 gtggttcggg cagctcatga aggggcctca gctgatcgcc catcttgctc aaattcatac
     9121 atggtttgaa gcgtatcgca ttgatattga cgagaggtag gttcaatgca aatgtgatta
     9181 aaagccagag atgtatagat ttaaataaga aggatagatg agcagggaaa tatatgctct
     9241 atctatcctt ttttgtacaa cagcactatc gaattgcccc cgcattcctt caataagaat
     9301 gaataggttt taatgttctg ccgataaaac tagctgatac cgggcttaac tttaattccc
     9361 tagcccatac agaaagttga ccaatatggt gaatttcgtg agcgatgata tggtgtaata
     9421 tttcatctcg cgtatataaa acacttgtct cccaaggaac gcttacaagt tcatctttta
     9481 tttgatctga atgtgtttgt aaaacatcaa ttatttcagt tcggaatgta tttgagagag
     9541 atttcacttt attgagtgtt tgataatcag cgaactgaac agcgatatct tcttttcctt
     9601 ggatagcacg aatccaacta tattccacat caataatatg aaaaagggta tataaaatat
     9661 tctctactcc gccaagacgg tttttaagta attcttcagt ggttagttga tgacaccaag
     9721 taaaccattg atctctaacc tgccagttat attcaaaaaa ttttatcact gaactcactc
     9781 caatactatc atgtatcata acaattagcc cttttttccg tgattcctct attattgaag
     9841 tgatgattga gaaatgttta cattctacct gttgtatggc attaaaaata ataatgcata
     9901 tctcgtcgat gatgctgtgc gtcttgttac ttttacaaag taagaatcgg cattttcttc
     9961 atatacaatt aggaaaaaac atactagact tgaagaagca gtgatacata ggagtgagaa
    10021 aatgaaagag ataaaagaag cttaccagca atgcggacag attgttggcg aatacgcgcc
    10081 agcctgtttc aaagcattat catatctccc gctaaagcaa agacaagcct cttgggcagt
    10141 attgtcgttt tgccacacgg cggccagtgc agacgaaaag gtattgcccg catttgaagc
    10201 taaagctgat catgtttacc aaaggacaaa taacggtaaa caacatctat ggaaggcttt
    10261 tgatcatgcg tatcggacct ttacattgga aagcgaacct tttcgggagt ttattgccgc
    10321 acaaaaagaa gacgccaagc cgtatgatga ccttgatgaa ctgctcatgt acgcatatcg
    10381 gacgggcggt gctgccggat tgatgctgct gccgatactg acacgccgaa aacaagatca
    10441 gctcaaacaa gcagccgtct ctctcggctt ggccatacag ctggttcgct tcttaagtga
    10501 tcttggcaca gatcagcaaa aaaaccgcat tccccgtcag gtaatgcagc aattcggcta
    10561 tacagaggct gatctccaaa aaggcaccgt aaataaagcg ttcacaatga cgtgggagta
    10621 tatcgctttt gaagcagaag cctaccttga agagtgtcag gatgccttgc cgctatttcc
    10681 gcagtattct caaaaaacgg tgaaagccgc tcttcatttg caccgggctg ttttagaaaa
    10741 aatccgggcg aagcagcacg atgtatttca atatcacttc gctctcacag agaccgaagt
    10801 gaagcagatt ctgtctgata tctaaaaaac acccggcctt gattgagccg ggtgttacgc
    10861 catacctttt tgaatccaga tacgtgagcg ccatcttctg tacattaaga ttccccggac
    10921 ccattcatcc gcgataaaag aaatccaaat gccggcaaga ccgaaaccga ggtggatgcc
    10981 gaaaagataa gcaagcggga ggccgatgcc ccacattgaa atcattgcca tgtaaaccgg
    11041 gaatttcgca tcccccgcag cccgcagaga gttaatgata atgacattaa acgagcggcc
    11101 tggttcaaga ataatggtca tggcaatcaa taggcttgca gttgctataa tgtcagggct
    11161 ttgtgtgaag agtccgatca ggtcttttga aaagatcgtc atcaaaacag aggtagccgc
    11221 agcaattccg agtgcccaat ataagctctt catgcagcgc tcataagcgg catcaaattg
    11281 tttgccgccg atataacggc cgattaagat ttgtgtaccc tggctgatcg cagtgccgaa
    11341 cagcaaaata aacatcgtaa tattttgcgt atacactttt gttgtcaacg cctgcgcgcc
    11401 catgatggcg ataaaatacg tgacaatcat ttgcgaaagg ttgtatgaaa gctgctctcc
    11461 cgcagaagga atgccgattt tcagcagctt gcgcaaatgc tctttatgca tatgaaagac
    11521 ttttttcagc gacatcttca gctggatgcg tttgttgaca atcacaatca tcgcgattaa
    11581 tccgatgacg cgggcgatag atgtggacat ggccacaccg gtaacgccga gaacaggaaa
    11641 gccgaacaaa ccgaaaatca caacaaagtt tccggcaatg tttaaaatgt tcatgccgat
    11701 agtgacaaac attgtatctt ttgtgtagcc gtagcttttt aagatcgcgc tgaatgtcat
    11761 gattaaagcc tgaataaagg acagacctcc gacaacttgt aaaaagactt tcgcatcagg
    11821 catcagtgcg tctgataatc ccatcatatg aagcagaggg acagccgcga aaaagacgac
    11881 ggcgctgatg gccaggctga tgaagaagtt ggcgccgatt gacacataag cgacttccat
    11941 ggcttctttc ttttgccgtg agcctagaaa ttgtgaaatg ataacggtcg ttcctgttgc
    12001 gataaagctg aacatcacga taattaaatt taaaatctgg ttgctgacgc cgactgctgc
    12061 cacgctgtta tccgagtatt ggctgagcat cagtgtatcg gcattaccca taaacatata
    12121 taatgagacc tcaataaaga tcggccaagt aagcgaaaat aatgagaacg ttttgtcagc
    12181 gggttttttc aaagcagttg atttgaagac agcttgtttc atagtgtcta acccctttcg
    12241 taaataaaat caacgtttta aagtgtacct ccatttcctt ataataaaaa gggatagaaa
    12301 cgatacttct tgtaaaaatc cgacttaaaa aggaggatga ttcaaatgcc ccgcatcctg
    12361 tttacagtcc cgccttttcc ggtatttatt gcagctgggg aaggggtttt taaaaaagga
    12421 gaaacccatg tgaaacgtgt attctccgtg tttgatctga tatatgtcaa acagggaacg
    12481 ttatatataa cggaaaatga aacatcgttt tctgttgaag gcggcgagta catcttgctt
    12541 tctcccggtc ttgaacacta cgggacgaag ggcagtgatg aagcaacctc ctactattgg
    12601 cttcacttcg atgaacatcg atatgaattt acggcaaagg gaggcagcaa ctggtctgag
    12661 cttcagcagg aaaaagggag cttcgaagag ccggcccgct acggattggc tttgccgaga
    12721 aaaggcaagg tgcagcgccc gcagtttatg gcgcagcagt ttgaaaagct gatcgattac
    12781 tccgcggaaa actctgattt gcccctcaga aagcaaatct tatttgagga gctgatgctg
    12841 catcttcaaa aagaagcgtt ccaaataccg tctgcgaaag agcgggtagc ctgggaggcg
    12901 gcccggtact tacaggagca ctataaggaa aagacgacaa tcaaggatct gtcgctcgcc
    12961 cttcactatc atcaggatta tgtgagccgc tgcatgcagc aggtgctcgg cgtaactccg
    13021 gcacaataca cgaaccgggt gagaatgacg gaagcgaagc gtcttttatc ctctacaaat
    13081 gataaaatgg gcgttattgc ggaaacggtc ggaatggaag atccgacata cttttcaaaa
    13141 ctctttaagc agatagaagg catttcacca attgaatacc ggaaaattgt cagccggaaa
    13201 gttcaataac cagacgaggg atgaacatga aaacaacaat ttacgatgtg gcaaaggcgg
    13261 cgggtgtctc gatcacaact gtgtcccgtg tgataaacaa tacggggaga atcagcgata
    13321 aaacacggca gaaggtcatg aatgtcatga atgaaatggc atacacgccc aatgttcacg
    13381 ccgcggcgtt aacgggaaaa cgaacgaata tgattgctct cgtggcgcct gatatttcaa
    13441 atccgtttta cggcgaactg gccaaaagca ttgaggaaag agcggatgag ctcggttttc
    13501 aaatgttgat ttgcagcacc gattacgatc cgaaaaaaga aacaaagtat ttttctgtgc
    13561 tgaaacagaa aaaggtggat ggcattattt ttgcaacagg gattgaaagc catgacagta
    13621 tgtctgcttt ggaggaaatc gccagtgaac aaattccgat tgccatgatt tctcaggata
    13681 agccgcttct tccgatggat attgttgtga tagatgacgt tcgtggcgga tatgaggctg
    13741 ccaagcatct tctgtcactc ggccacacga acatcgcctg cattattgga gacgggtcaa
    13801 cgacaggcga aaaaaataga atcaaaggct tccgtcaggc gatggaggaa gcgggcgtgc
    13861 ccattgatga atcacttatc atccagacgc ggttttcctt ggaaagcggc aaggaagaag
    13921 cgggaaaatt gctcgacaga aacgctccga ctgctatttt tgccttcaac gacgtattgg
    13981 cttgtgccgc catacaagct gcgagaataa gaggcataaa agtgccggat gatctttcta
    14041 tcattggttt tgataatacg atactcgcag aaatggcggc tccgcccctg acaaccgtag
    14101 cccagccgat aaaagagatg gggcggagcg tcatcgaact gctggcagaa gcaatagagg
    14161 gaaaacgaaa ggcgaaacaa aaaatagtgc tcccgcctga gcttgtagtc agacattcta
    14221 catcaccgct caacacatga gcccgctaat gagcgggttt tttcattatg acagttgaag
    14281 ccaaaaaaac atattgcgtg taaaccaaag gcagtgtaaa atgaaaccat cttttgagaa
    14341 agcgcttgcg caaaatggca gagcggatag aaccgctgtt tttttagctg ttaagagaaa
    14401 gcgctttccc aaagcgagcc cgaaatgaga taaaggagag gatgggacgt ggaacatcaa
    14461 gtaaggtgcg cagtattggg attaggaagg ctcggttatt atcatgcgaa aaatctcgtc
    14521 accagtgtgc cgggggcaaa gctggtttgt gtcggtgatc cgttaaaagg gagagcggag
    14581 caggttgcca gagaactcgg tatcgaaaaa tggtcagagg acccgtatga agtgttagaa
    14641 gataccggca ttgacgctgt cattatcgta acgccgacaa gcacacatgg tgatatgatc
    14701 atcaaagctg ccgagaacgg caaacagatc tttgttgaaa aaccgctgac attaagcctt
    14761 gaggaatcta gagcagtttc tgaaaaagtg caggagacag gtgtcatctg ccaagtcggc
    14821 tttatgagac ggttcgatcc agcatacgca gatgccaaac ggcggatcga cgctggagaa
    14881 atcggcaaac ctatctatta taaaggcttt acgcgcgacc aaggcgcgcc tcccgcagaa
    14941 tttatcaaac acagcggtgg gatttttatc gactgttcca tccatgacta tgatattgcc
    15001 cgttatttgc taggggcgga aattacttct gtttcaggac acggcaggat tctgaacaat
    15061 ccgtttatgg agcagtacgg cgatgtggat caggcgctga cgtatattga atttgactcc
    15121 ggcgcagcgg gggacgtcga ggcaagcaga acctctccat atggacatga cattcgggcg
    15181 gaggtgatcg ggacagaggg cagtattttc atagggacat tgagacatca acatgtgacc
    15241 atcctatcgg ctaaagggag cagttttgat atcattccag actttcaaac tcgttttcat
    15301 gaagcctact gcttggagct tcagcatttc gccgagtgtg tccggaatgg aaaaacaccg
    15361 attgtgacag atattgatgc gacgatcaat ttagaagtgg gtatcgccgc aaccaattcc
    15421 tttcgaatcg gcaggccggt acagctagat gtgaagcacg cttatacagg tatgtaaaag
    15481 ctaaatatgt tgcattttag gctttccgca aaaaaaagca aggacatttt tagcccttgc
    15541 tttctctttt ctcatataaa tagtacatat aatcagtagg tatgcctgaa tggcccagct
    15601 gtctcagcat ggcggttacg ttacctctat ggtaagtccc gtgattgacg acatgcagga
    15661 tggtgtctgc ataggttgat tccagtgtac ctagtttcgg atgctgcatt gtgaaggtct
    15721 gttctaagtc cgtctggcgg ctgaagaaat catgatactg tgactccagc tcggcagcgt
    15781 gctgtttaat cgctgccata ttaccttgcg cggactctaa tttgcctgcg ctgtctataa
    15841 tctcttggta ggccactccc gaaagaacat tcagccaaat gtagtcagcc ctgcacatat
    15901 gaagcagcac gtcgctgaca gaaggaaata cgctctttac ttcttgatag gcagtttcct
    15961 ccggcaggtt ttcgatatgg gtaaatattt tcttgtttgc ccaagaatga tagtcataaa
    16021 actgttttgc atcagtcatc agcatgcccc cttttctaag aaattcgttt ttttcatctg
    16081 tttctccttc aattgcaaaa gagtgacacc ccaaaatatc ctgccgctgc ccacataacc
    16141 gctgcagagc atttgtttac gatcagcata agcctgccgc tcgtatctat cgtctgaaac
    16201 aaccggcccg ctattgcaag gctgataaac caaatccaag acacagcgat gcaggcggcc
    16261 ataaagagcc atttctcaag ccccgaatat tgaagagagc tcgtgccgat gacgccgatc
    16321 gtgtccagaa tggcatgcgg gtttaaaaga gaaacagcgg ccgcaaacgc agcttgcttt
    16381 tttggtgtga acgtatgttt ctcattttgg cttgtgttcg gacggctgtt ccaagtcacc
    16441 cagcccatat aaagcaaaaa taaaaatccg ccggccatca tgactgtctc aaacacaggc
    16501 agctcctgca caatgacaga cacgcccgca acggctaata cgattaacag ggtatcgcag
    16561 actgaagcac tgatgacagc tgggagagcc cgccaaatat gcttttgcca cgcgccttgc
    16621 tgaaaaataa acacattctg cactcccagc ggcaaaatta agccaaacgc gagcacaatt
    16681 ccgtgaatga ttgcattcat gctgaaaaag ctcccttcac atttttttca atcataagag
    16741 agattgtcac taaagtctcc agccatttgg ttgggttaga aaccagccaa atgtataatg
    16801 tgtaaaaaag gggggcatga ccttgtcgca atggcagcca agccgaaagt cggatgttcc
    16861 gctgcatcgg cagatcgaac aatatatgaa agacaagatt cttcacggag agtgggctgt
    16921 agggacgaaa atcccctcac agagaacgct ggccggcatg tttcaagtca accgcagcac
    16981 agtcacagca gccatagatg aactcacgtc tcaaggcttg ttagagggaa gaagaggcgg
    17041 cggtacgaag gttgtaaaca gtacttggag cgtgctggcg gctgagcctc cgcttgattg
    17101 gagcgattac gtccgttcgg gcattcatcg cgccaattct tccatcattc aagctattaa
    17161 tcagaacgaa ccaagagcgg atatcatcag attaggaact ggagaacttt caccggatct
    17221 tgtgcctgct gacacaattg gacggatgtt tcagcaaatc aatccgggcg ccctgtcttt
    17281 aggatatgag cagccgaaag gaaaccgtca gctgcgggag gcagtagccg accatttaaa
    17341 aggaaagaag atccatgtgt caccgtctgc aattttaatt gtgtccggtg cacttcaggc
    17401 acttcagctc atctcaattg gacttttaaa acgagattct gtcattttga cggagaagcc
    17461 gtcctacctt caatccttgc atgtatttca atcagctggg atgcggcttc gcggcttgcc
    17521 gatggatgat gaaggggtca aagcggggct tgtttcttct aatcgaaaac aatatggagg
    17581 acagctgctt tacacgattc cgtcgtttca taatccgaca ggcacagtca tgtcagagca
    17641 gcgaaggaaa gagatcatca gcctgtcaaa aaaagagcag ctgcccatca ttgaggatga
    17701 tgcgtacggt gatttatggt ttgaagaaaa accgccgcag ccgttgaaag caatggatca
    17761 tgagggcaat attctgtatc tgggcacgtt ttcaaaaacg gttagccccg gtctgcgaat
    17821 cggctggctt gccggtccgg agccggttat tgaaaggctg gcggacatta aaatgcagac
    17881 agactacgga tcaagcggcc tgtcccagtg ggcggctgcc gagtggctgt cacaggggta
    17941 ttatgaagag catctgactt gggtacgcag gaagcttaaa gaaaggagag acgcagccgt
    18001 tcattttctc gagcggtatg ccggggacat tgccacgtgg cggattcccg caggcggctt
    18061 ttatatttgg gtgacatttc acaaaaacct gcctgtcagc cgtttctttt atggattgct
    18121 gaaacggcag gtgcttgtga atcccggcta catttatgac ggtgaagacc gaaacagcat
    18181 caggctgtca tattcctatg catctcttgg agatttggaa actggcatta aagcggcagc
    18241 tgaaacagca cgctgcctga tgatgtccta agctttggtt atacgatgac agctcccagt
    18301 gccctggcga aggcaatcgc gtgctcaggt gcgattttgc agcctttcaa tttgtcgagg
    18361 gagacatgaa gctgttcaaa acggcacgtg ctgatgtcca tgttttgaag ggatgtgccg
    18421 gtaaagctgg cgccttccaa ttcgcatccg tcaaagtgtg tctgctggag caccgtattg
    18481 ctgcattcac tttgcataag agcacagtga tcaaatcgaa cttgtttcat atttgagtac
    18541 gaaaatgagc tgaaatgtcc gtggcattcc tcgaatgaaa catttcgcag cgttgcttcc
    18601 gccacattca ttccaaccat ttttgactgc ttaacagaag ttctgtgaat gacagccccg
    18661 ctgaaatcgg cgtttgataa atcacatttt tcaaagatca catcggtcag ttcaatatgc
    18721 cgaaaagaca catcgataaa gacgacattt ctgaataccg ttttttcaac acagagtctt
    18781 tcgatatctt cgccgcagat tgtacaatct tcaaacaaat gcatgctgat tacatcatcc
    18841 tgcgtcacgg catcatgaaa atctgcggtt tgcaggtttt ccggtatgtt cggtttttga
    18901 attgcgattt tattcatgtg atgacatcct ttgctgcccg aaaaacagag gcttccgggt
    18961 tcaatttaat agatcgttaa ggaaattgat acatatagta aatcgtgaag agccttttct
    19021 tggtacagca gccagcttgt tttgtaagca taaatggaaa gcttcctata cgtcaaggcg
    19081 tttacaggcc gggaaagcca aagggaacag gaggaatgcg gaatggggca ttacatcaaa
    19141 accgaggagc atgtgacact gtttgtagag gatatcggac atggaaggcc gatcatcttt
    19201 ttgcacgggt ggccgttgaa tcataagatg tttgaatatc aaatgaatga gcttccgaaa
    19261 aggggatttc gttttatcgg cgttgattta cggggatatg ggcaatctga ccgcccttgg
    19321 gaaggctacg attatgacac gatggccgat gatgtgaaag cagtcattta tacgctgcag
    19381 cttgagaatg cgattcttgc cggtttttca atgggcggcg ccattgcaat ccgttatatg
    19441 gcaaggcatg aaggagccga tgttgataag ctgattttac tgtctgcggc ggcccccgcg
    19501 tttacaaaac gcccgggtta tccgtacggg atgaggaagc aggatattga cgatatgatt
    19561 gaattgttca aagctgatcg gcccaaaaca ctggctgatt tagggaaaca gttttttgag
    19621 aaaaaagtgt ctccagagct tagacagtgg tttctcaatc tgatgctgga ggcctcctcc
    19681 tacgggacga tccactcggg catcgcatta agagacgaag atctcagaaa ggaacttgct
    19741 gcaatcaagg tgccgacgct gatcctgcac gggagaaagg atagaattgc gccgtttgat
    19801 tttgcgaaag aattgaagcg cggcatcaaa cagtcggaat tggttccgtt tgcaaacagc
    19861 gggcacggag cattttatga ggaaaaagag aagatcaaca gtttgattgc gcagttctcc
    19921 aactcataag aaaaaacccg acattgatcg ggttttttat ataattcctc tgttttgcag
    19981 tgcgttaatg atgagatcag ctccatcgga aatagaggtc tggtctgact caatgatgaa
    20041 atcgggtgaa agcggcgctt catacggaga atcgatcccg gtgaaatgtt tgatctctcc
    20101 gtttcgcgct tttttataaa gcccttttgg atcgcgctgt tcacaaacat gcagcgggca
    20161 cttcacataa atttcgaaga actcaccttt aggaaagagc gctctaacca tgtcccgatc
    20221 ctctctgaat ggagaaataa aagccgttaa aatcatttgc ccgctgtcga caaacagctt
    20281 cgccacttct ccgatccggc ggatgttttc aatcctgtca ccagtctgaa atccaagatc
    20341 tttgtttaag ccgtggcgga tattatcacc gtcaagcacg tagctctgaa tgcccttgcg
    20401 gtaaagcttt tcatcgacag cattggccag caccgatttt ccggagccgg acaaacctgt
    20461 aaaccaaagg acgcagcttt tgtgtccgtt taaggactgt ctgtcagact ttgagatggc
    20521 agcgggatgc caaatgatgt tcggattgtg tgtcattgca attccccgct gttttgcttg
    20581 atggcaacag gctgttggtg aagtcccttg atcagcacgg ctgcgacctc aggccggctg
    20641 aattctttag gcggcttttt gccttggcgg agaagctctc tcacttttgt gcctgataag
    20701 tggatgtggt ctctcgggct gtgcggacat gttttggagg tgcccatgtt tccgcatttt
    20761 cggcaataaa agctgtgctc aaaaaacagc ggcttgatgc ccagctcttc ctctgtgaat
    20821 gattg
//
