GCF_020179775.1 - 18 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_JAIONG010000001.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	terpene-precursor,NRP-metallophore,NRPS,RiPP-like	19,291	84,629	High	bacillibactin	NRPS:Type I
Region 1.2	lanthipeptide-class-ii	250,917	277,270

NZ_JAIONG010000002.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	transAT-PKS,T3PKS,NRPS	162,050	272,134	High	bacillaene	NRPS:Type I+PKS:Type I

NZ_JAIONG010000003.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 3.1	T3PKS	91,741	132,841
Region 3.2	terpene	212,554	234,437

NZ_JAIONG010000004.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 4.1	betalactone,transAT-PKS,NRPS	1	80,319	High	mycosubtilin	NRPS:Type I+PKS

NZ_JAIONG010000007.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 7.1	terpene-precursor	182,464	203,354

NZ_JAIONG010000008.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 8.1	PKS-like	66,462	107,706

NZ_JAIONG010000009.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 9.1	transAT-PKS	13,034	101,264	High	macrolactin H	PKS

NZ_JAIONG010000010.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 10.1	RiPP-like	44,606	57,684

NZ_JAIONG010000011.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 11.1	other	90,742	118,379	High	bacilysin	other:other

NZ_JAIONG010000020.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 20.1	transAT-PKS-like	23,137	69,738	Medium	difficidin	PKS

NZ_JAIONG010000021.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 21.1	NRPS	1	55,299	High	surfactin	NRPS:Type I

NZ_JAIONG010000027.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 27.1	transAT-PKS	1	34,356	Low	difficidin	PKS

NZ_JAIONG010000033.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 33.1	terpene	13,862	29,395

NZ_JAIONG010000036.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 36.1	transAT-PKS-like	1	22,998	Low	difficidin	PKS

NZ_JAIONG010000039.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 39.1	NRPS	1	18,628	Low	plipastatin	NRPS:Type I

NZ_JAIONG010000040.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 40.1	RiPP-like	8,147	18,478

No secondary metabolite regions were found in these records:: NZ_JAIONG010000005.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000006.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000012.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000013.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000014.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000015.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000016.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000017.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000018.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000019.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000022.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000023.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000024.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000025.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000026.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000028.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000029.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000030.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000031.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000032.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000034.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000035.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000037.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000038.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000041.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000042.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000043.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000044.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000045.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000046.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000047.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000048.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000049.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000050.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000051.1 (Bacillus amyloliquefaciens); NZ_JAIONG010000052.1 (Bacillus amyloliquefaciens)

Compact view

NZ_JAIONG010000001.1 - Region 1 - NRP-metallophore,NRPS,RiPP-like,terpene-precursor

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Location: 19,291 - 84,629 nt. (total: 65,339 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase reductase

K8B35_RS00220: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

K8B35_RS00295: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

K8B35_RS00345: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

K8B35_RS00350: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

K8B35_RS00400: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: esterase hydrolase

K8B35_RS00140: thioesterase superfamily protein

smcogs: SMCOG1144: thioesterase superfamily protein

K8B35_RS00185: isochorismatase

smcogs: SMCOG1027: isochorismatase

K8B35_RS00280: isochorismatase

smcogs: SMCOG1027: isochorismatase

Isomerases: isomerase

K8B35_RS00290: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase synthetase

K8B35_RS00160: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

K8B35_RS00275: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

K8B35_RS00285: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000616.4	2.44	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0001185.5	1.65	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000309.5	1.07	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5	1.04	NRPS	paenibactin	Paenibacillus elgii B69
BGC0002075.3	0.87	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000343.5	0.86	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001132.4	0.77	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.76	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.75	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.75	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000616.4	0.95	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0001185.5	0.94	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000309.5	0.81	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5	0.80	NRPS	paenibactin	Paenibacillus elgii B69
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000343.5	0.74	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

K8B35_RS00160: PT_FPPS_like

Domain 1 (58 - 284): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.61 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.15 out of 29.38

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.49 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.87 out of 27.78

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.49 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.91 out of 29.38

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.52 out of 27.78

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.23 out of 21.55

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.11 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.89 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19

Confidence: medium

Additional weak hits (17):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.88 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.45 out of 26.06

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.44 out of 31.73

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.84 out of 29.25

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.61 out of 32.74

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.52 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.31 out of 29.38

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.58 out of 26.06

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.44 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.15 out of 26.06

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.10 out of 29.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.86 out of 26.06

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.11 out of 33.14

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 21.63 out of 30.12

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Terpene

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 19290 - 84629:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 32837 - 84574:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

K8B35_RS00275: Gly - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (456..855): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FSMTFDISGLELQALVGGETNLYGPTETTIWSAA
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1513..1929): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LSTHFDFSVWEGNQIFGGEVNMYGITETTVHVSY
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

K8B35_RS00285: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (31..435): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: SISLYPLSSPGGALQVGGAQQVFGMAEGLVNYTR
Nearest Stachelhaus code(s):: diOH-Bz PLPAQGVVNK (100% 8Å match); diOH-Bz or Sal PLPAQGVVNK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_JAIONG010000001.1 - Region 2 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 250,917 - 277,270 nt. (total: 26,354 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

K8B35_RS01360: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

K8B35_RS01370: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.57	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000517.4	0.57	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001210.5	0.55	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0001311.5	0.54	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0000623.3	0.54	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000525.5	0.54	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0001229.4	0.53	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0001391.3	0.52	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000500.5	0.51	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.57	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000517.4	0.57	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001210.5	0.55	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0001311.5	0.54	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0000623.3	0.54	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000525.5	0.54	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0001229.4	0.53	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0001391.3	0.52	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000500.5	0.51	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for K8B35_RS01360

K8B35_RS01365

Leader:

MKKDMVKKASGFIEEDELISLANGDNATGG

Core:

ATPATVVLTATIGLTGTTFTVTLSAASCPTSACTKQCNK

Core with dehydrations:

ADhbPADhbVVLDhbADhbIGLDhbGDhbDhbFDhbVDhbLDhaAADhaCysPDhbDhaACysDhbKQCysNK

antiSMASH-DB 4.0 matches for K8B35_RS01365

100.0%

NZ_CP033054.1and 11 others:

NZ_CP033054.1 Lanthipeptides: D9777_RS18840_lanthipeptideNZ_CP047268.1 Lanthipeptides: GKS41_RS18605_lanthipeptideNZ_CP047268.1 Lanthipeptides: GKS41_RS18605_lanthipeptideNZ_CP072563.1 Lanthipeptides: J6600_RS15935_lanthipeptideNZ_CP072563.1 Lanthipeptides: J6600_RS15935_lanthipeptideNZ_CP116014.1 Lanthipeptides: PF996_RS17885_lanthipeptideNZ_CP116014.1 Lanthipeptides: PF996_RS17885_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12560_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12560_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01365_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01365_lanthipeptide

Lanthipeptides: D9777_RS18840_lanthipeptide

1

ATPATVVLTATIGLTGTTFTVTLSAASCPTSACTKQCNK

39

ATPATVVLTATIGLTGTTFTVTLSAASCPTSACTKQCNK

1

ATPATVVLTATIGLTGTTFTVTLSAASCPTSACTKQCNK

39

97.4%

NZ_CP017953.1and 15 others:

NZ_CP017953.1 Lanthipeptides: BAMY_RS16390_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptide

Lanthipeptides: BAMY_RS16390_lanthipeptide

1

ATPATVVLTATIGLTGTTFTVTLSAASCPTSACTKQCNK

39

ATP TVVLTATIGLTGTTFTVTLSAASCPTSACTKQCNK

1

ATP-TVVLTATIGLTGTTFTVTLSAASCPTSACTKQCNK

38

76.9%

NZ_JALAUA010000003.1and 1 other:

NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04870_lanthipeptide

Lanthipeptides: MOD32_RS04870_lanthipeptide

1

ATPATVVLTATIGLTGTTFTVTLSAASCPTSACTKQCNK

39

TP T +LTA LTGTTFTVTLSAASCPTSACT CNK

1

GTPVTAILTA---LTGTTFTVTLSAASCPTSACTNLCNK

36

with 112 more sequence matches

Only the first 10 are displayed here.

74.4%

NZ_CP047645.1and 5 others:

NZ_CP047645.1 Lanthipeptides: GSN02_RS17435_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptide

Lanthipeptides: GSN02_RS17435_lanthipeptide

1

ATPATVVLTATIGLTGTTFTVTLSAASCPTSACTKQCNK

39

TP T ++TA LTGTTFTVTLSAASCPTSACT CNK

1

GTPVTAIITA---LTGTTFTVTLSAASCPTSACTNLCNK

36

53.8%

NZ_CKMQ01000043.1and 8 others:

NZ_CKMQ01000043.1 Lanthipeptides: AE832_RS09950_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS02065_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS02065_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS01730_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS01730_lanthipeptideNZ_LR216041.1 Lanthipeptides: E0F00_RS05470_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05985_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05985_lanthipeptide

Lanthipeptides: AE832_RS09950_lanthipeptide

7

VLTATIGLTGTTFTVTLSAASCPTSACTKQCNK

39

++ ATI G TFTVTL+A +CPTS CTK CNK

5

IIPATISFVGVTFTVTLNAGACPTSGCTKSCNK

37

53.8%

NZ_PNGD01000001.1and 1 other:

NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00165_lanthipeptide

Lanthipeptides: CJ239_RS00165_lanthipeptide

7

VLTATIGLTGTTFTVTLSAASCPTSACTKQCNK

39

++ ATI G TFTVTL+A +CPTS CTK CNK

5

IIAATISFAGVTFTVTLNAGACPTSGCTKSCNK

37

46.2%

NZ_BLIS01000009.1and 1 other:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptide

Lanthipeptides: GVO03_RS04825_lanthipeptide

1

ATPATVVLTATIGLTGTTFTVTLSAASCPTSACTKQC

37

A+PAT T IG T +SA +CPTSACT+ C

4

ASPATP-YTPAIGKGVIAVTAFVSANTCPTSACTRAC

39

46.2%

NZ_CP009288.1and 3 others:

NZ_CP009288.1 Lanthipeptides: PDUR_RS29295_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptide

Lanthipeptides: PDUR_RS29295_lanthipeptide

3

PATVVLTATIGLTGTTFTVTLSAASCPTSACTKQC

37

P T +LT T T T VT+SA+ CPT+ CT QC

6

PETTILT-TSSWTCITAGVTVSASLCPTTKCTSQC

39

46.2%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09625_lanthipeptide

Lanthipeptides: CQS04_RS09625_lanthipeptide

1

ATPATVVLTATIGLTGTTFTVTLSAASCPTSACTKQC

37

ATP T+V+TA G +SA SCPT+ACT+ C

1

ATP-TIVITAITGY--------ISANSCPTTACTRAC

28

46.2%

NZ_QRWZ01000002.1and 3 others:

NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide

Lanthipeptides: DWX18_RS02625_lanthipeptide

2

TPATVVLTATIGLTGTTFTVTLSAASCPTSACTKQC

37

TPAT T IG T +SA +CPTSACT+ C

2

TPATP-YTPAIGKGVIAVTAFVSANTCPTSACTRAC

36

43.6%

NZ_WHOM01000078.1and 1 other:

NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29290_lanthipeptide

Lanthipeptides: GCN81_RS29290_lanthipeptide

8

LTATIGLTGTTFTVTLSAA---SCPTSACTKQC

37

+T TI L T V SAA CPTS CTK+C

8

ITPTI-LPATGVIVGASAALQGGCPTSGCTKRC

39

41.0%

NZ_CP102975.1and 1 other:

NZ_FMOE01000002.1 Lanthipeptides: BJT27_RS07810_lanthipeptide

Lanthipeptides: NW953_RS00175_lanthipeptide

1

ATPATVVLTATIGLTGTTFTVTLSAASCPTSACTKQCNK

39

ATPA V+ T V S A CPT AC+ +C K

1

ATPAVVI---------TGILVAASTAQCPTLACSSRCGK

30

41.0%

NZ_JAENHN010000066.1and 1 other:

NZ_JAENHN010000066.1 Lanthipeptides: JHL18_RS24400_lanthipeptide

Lanthipeptides: JHL18_RS24400_lanthipeptide

1

ATPATVVLTATIGLTGTTFTVTLSAASCPTSACTKQCN

38

TP V+ AT+GLT T A C T ACT C+

2

GTPCAVI--ATVGLTIKVAT----AVVCETGACTGYCH

33

MIBiG 4.0 matches for K8B35_RS01365

25.6%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

21

VTLSAASCPTSACTKQC

37

V +SAA CPT+ CT +C

21

VGVSAAFCPTTKCTSRC

37

15.4%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

28

CPTSACTKQC

37

CPT+ CT +C

17

CPTTKCTSKC

26

12.8%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

15

TGTTFTVTLSAASCPTS

31

TG + A+C S

13

TGALMGCNMKTATCHCS

29

K8B35_RS01375

Leader:

MKKTKILKTPELKVTKDLNLIDPCGDVLEEIKEHEVSGA

Core:

FNTWNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

Core with dehydrations:

FNDhbWNDhbDhbDhbDhbDhaLGGILVDhaEVLGNKGKVCysDhbGDhbKECysQGDhbCys

antiSMASH-DB 4.0 matches for K8B35_RS01375

100.0%

NZ_CP017953.1and 27 others:

NZ_CP017953.1 Lanthipeptides: BAMY_RS16400_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptideNZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptideNZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptideNZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptideNZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptideNZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptideNZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptideNZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptideNZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptide

Lanthipeptides: BAMY_RS16400_lanthipeptide

1

FNTWNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

FNTWNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

1

FNTWNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

91.9%

NZ_CP047645.1and 7 others:

NZ_CP047645.1 Lanthipeptides: GSN02_RS17445_lanthipeptideNZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04860_lanthipeptideNZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04860_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18560_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18560_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03725_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03725_lanthipeptide

Lanthipeptides: GSN02_RS17445_lanthipeptide

1

FNTWNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

FNTWNTTTTS+G ILVSEV GNKGKVCTGTKECQGTC

1

FNTWNTTTTSVGTILVSEVFGNKGKVCTGTKECQGTC

37

60.5%

NZ_CM000756.1and 7 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS34475_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide

Lanthipeptides: BTHUR0011_RS34475_lanthipeptide

1

FNTWNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

NTWNTT TS I++SE GNKGKVCT T EC C

1

INTWNTTATSTS-IIISETFGNKGKVCTYTVECVNNC

36

with 110 more sequence matches

Only the first 10 are displayed here.

56.8%

NZ_JAGKQT010000007.1and 3 others:

NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09860_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide

Lanthipeptides: J2M30_RS09860_lanthipeptide

2

NTWNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

NTWNT +TS I VS +GN GKVCT T EC C

1

NTWNTISTSTC-IAVSHFVGNDGKVCTYTVECVNNC

35

54.1%

NZ_CP009288.1and 3 others:

NZ_CP009288.1 Lanthipeptides: PDUR_RS25150_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide

Lanthipeptides: PDUR_RS25150_lanthipeptide

5

NTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

NT TTS IL+S LGN G VCT TKEC +C

4

NTLTTS-TSILISMTLGNNGWVCTATKECMPSC

35

51.3%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide

Lanthipeptides: MT347_RS12955_lanthipeptide

4

WNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

W TT TSL VS V GN G+VCT T ECQ C

5

WTTTITSLTCYGVSWVAGNNGQVCTATVECQNNC

38

48.6%

NZ_CP009280.1and 1 other:

NZ_CP009280.1 Lanthipeptides: P40081_RS01820_lanthipeptide

Lanthipeptides: P40081_RS01820_lanthipeptide

5

NTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

NT TTS I +S LGN G VCT +KEC +C

4

NTLTTSTS-IFISRGLGNDGWVCTWSKECMPSC

35

48.6%

NZ_GG657757.1and 1 other:

NZ_GG657757.1 Lanthipeptides: SSQG_RS20730_lanthipeptide

Lanthipeptides: SSQG_RS20730_lanthipeptide

3

TWNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

+ N TT SL GI GN G CT TKECQ +C

3

SANFTTFSLSGIF-----GNDGDCCTLTKECQASC

32

48.6%

NZ_KL997439.1and 1 other:

NZ_KL997439.1 Lanthipeptides: IQ62_RS47105_lanthipeptide

Lanthipeptides: IQ62_RS47105_lanthipeptide

3

TWNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

+ NTTT +L S LG+KG CT TKECQ +C

3

SLNTTTFTL-----SAQLGDKGDCCTATKECQPSC

32

47.4%

NZ_WHOM01000078.1and 1 other:

NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptide

Lanthipeptides: GCN81_RS29300_lanthipeptide

4

WNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

W TT +SL S VLGN G CT T ECQ C

4

WGTTLSSLSCYGASYVLGNNGNFCTATAECQSNC

37

45.9%

NZ_QKTG01000020.1and 1 other:

NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide

Lanthipeptides: DEI99_RS16920_lanthipeptide

6

TTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

TT T+L VS LGN G CT T ECQ C

5

TTVTTLSCYGVSWALGNDGNFCTATVECQSNC

36

45.9%

NZ_WITJ01000001.1and 1 other:

NZ_WITJ01000001.1 Lanthipeptides: GHI93_RS00065_lanthipeptide

Lanthipeptides: GHI93_RS00065_lanthipeptide

3

TWNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

TWN +S+ V+ LGN G VCT T ECQ C

3

TWNLVFSSV----VTLALGNNGYVCTWTHECQANC

33

44.7%

NZ_BMRY01000003.1and 24 others:

NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide

Lanthipeptides: IE140_RS12370_lanthipeptide

4

WNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

W T +SL S VLGN G CT T ECQ C

4

WGTIVSSLSCYGASYVLGNNGNFCTATAECQNNC

37

MIBiG 4.0 matches for K8B35_RS01375

35.1%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

16

VSEVLGNKGKVCTGTKECQGTC

37

+S LGN G CT TKECQ C

8

LSNALGNNGGWCTLTKECQPNC

29

32.4%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

16

VSEVLGNKGKVCTGTKECQGTC

37

+S LGNKG CT T EC +C

6

ISCRLGNKGAYCTLTVECMPSC

27

17.9%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

27

CTGTKECQGTC

37

CT +KECQ C

28

CTLSKECQPNC

38

allorf_252303_252449

Leader:

MLKLYTIYVFFHVIPLTMRMFLQSLPIA

Core:

RISCRIIFFINCKKYDILSA

Core with dehydrations:

RIDhaCysRIIFFINCysKKYDILDhaA

antiSMASH-DB 4.0 matches for allorf_252303_252449

100.0%

NZ_CP017953.1and 11 others:

NZ_CP021011.1 Lanthipeptides: allorf_1217915_1218061_lanthipeptideNZ_CP033054.1 Lanthipeptides: allorf_3701381_3701527_lanthipeptideNZ_CP041784.1 Lanthipeptides: allorf_3241959_3242105_lanthipeptideNZ_CP047268.1 Lanthipeptides: allorf_3722701_3722847_lanthipeptideNZ_CP072563.1 Lanthipeptides: allorf_3252899_3253045_lanthipeptideNZ_CP097784.1 Lanthipeptides: allorf_3200225_3200371_lanthipeptideNZ_CP116014.1 Lanthipeptides: allorf_3458073_3458219_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: allorf_294511_294657_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: allorf_145128_145274_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: allorf_252303_252449_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: allorf_294859_295005_lanthipeptide

Lanthipeptides: allorf_3266320_3266466_lanthipeptide

1

RISCRIIFFINCKKYDILSA

20

RISCRIIFFINCKKYDILSA

1

RISCRIIFFINCKKYDILSA

20

95.0%

NZ_CP048002.1:

Lanthipeptides: allorf_1109061_1109207_lanthipeptide

2

ISCRIIFFINCKKYDILSA

20

ISCRIIFFINCKKYDILSA

2

ISCRIIFFINCKKYDILSA

20

23.1%

NC_023073.1and 9 others:

NZ_CP016395.1 Lanthipeptides: BBJ33_RS20395_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21475_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19560_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19590_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20475_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06455_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06170_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06305_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19360_lanthipeptide

Lanthipeptides: U722_RS20000_lanthipeptide

9

FINCKKYDILSA

20

F+ C+ DIL A

13

FLRCQNDDILPA

24

allorf_252335_252418

Leader:

MMKKMMRQDMRAIGS

Core:

DCKNIRIVSGIT

Core with dehydrations:

DCysKNIRIVDhaGIDhb

antiSMASH-DB 4.0 matches for allorf_252335_252418

100.0%

NZ_CP017953.1and 12 others:

NZ_CP021011.1 Lanthipeptides: allorf_1217947_1218030_lanthipeptideNZ_CP033054.1 Lanthipeptides: allorf_3701413_3701496_lanthipeptideNZ_CP041784.1 Lanthipeptides: allorf_3241991_3242074_lanthipeptideNZ_CP047268.1 Lanthipeptides: allorf_3722733_3722816_lanthipeptideNZ_CP048002.1 Lanthipeptides: allorf_1109093_1109176_lanthipeptideNZ_CP072563.1 Lanthipeptides: allorf_3252931_3253014_lanthipeptideNZ_CP097784.1 Lanthipeptides: allorf_3200257_3200340_lanthipeptideNZ_CP116014.1 Lanthipeptides: allorf_3458105_3458188_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: allorf_294543_294626_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: allorf_145159_145242_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: allorf_252335_252418_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: allorf_294891_294974_lanthipeptide

Lanthipeptides: allorf_3266352_3266435_lanthipeptide

1

DCKNIRIVSGIT

12

DCKNIRIVSGIT

1

DCKNIRIVSGIT

12

allorf_273844_274074

Leader:

MVLSDRNAIMKADKGRGRTPFPFFHENRLSESAGL

Core:

LQNVRVLKFPRHFRFLSRLPWLRRRSAPCPEAAICPAAEAS

Core with dehydrations:

LQNVRVLKFPRHFRFLDhaRLPWLRRRDhaAPCysPEAAICysPAAEADha

antiSMASH-DB 4.0 matches for allorf_273844_274074

100.0%

NZ_CP017953.1and 12 others:

NZ_CP021011.1 Lanthipeptides: allorf_1239450_1239680_lanthipeptideNZ_CP033054.1 Lanthipeptides: allorf_3724234_3724464_lanthipeptideNZ_CP041784.1 Lanthipeptides: allorf_3263499_3263729_lanthipeptideNZ_CP047268.1 Lanthipeptides: allorf_3744242_3744472_lanthipeptideNZ_CP048002.1 Lanthipeptides: allorf_1130609_1130839_lanthipeptideNZ_CP072563.1 Lanthipeptides: allorf_3274357_3274587_lanthipeptideNZ_CP097784.1 Lanthipeptides: allorf_3221763_3221993_lanthipeptideNZ_CP116014.1 Lanthipeptides: allorf_3479615_3479845_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: allorf_316050_316280_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: allorf_123482_123712_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: allorf_273844_274074_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: allorf_316397_316627_lanthipeptide

Lanthipeptides: allorf_3287857_3288087_lanthipeptide

1

LQNVRVLKFPRHFRFLSRLPWLRRRSAPCPEAAICPAAEAS

41

LQNVRVLKFPRHFRFLSRLPWLRRRSAPCPEAAICPAAEAS

1

LQNVRVLKFPRHFRFLSRLPWLRRRSAPCPEAAICPAAEAS

41

31.7%

NZ_CP011020.1:

Lanthipeptides: allorf_1818981_1819088_lanthipeptide

16

LSRLPWLRRRSAPC-----PEAAICPA

37

L+RL + RRS P AAICPA

1

LARLCFGLRRSLPVRHGQRQNAAICPA

27

19.5%

NZ_FOYL01000002.1:

Lanthipeptides: allorf_0629623_0629850_lanthipeptide

17

SRLPWLRRRSAPC

29

SR W+R RS PC

14

SRATWVRMRSGPC

26

with 2 more sequence matches

14.3%

NZ_BNCA01000011.1:

Lanthipeptides: allorf_160997_161218_lanthipeptide

20

PWLRRRSAPCPEAAICP

36

P R+ PCP A CP

37

PPDRQPPGPCPPAGSCP

53

13.5%

NZ_JAHTIK010000001.1:

Lanthipeptides: allorf_2154999_2155214_lanthipeptide

19

LPWLRRRSAPCP

30

LPW R PCP

2

LPWRMRDGGPCP

13

Lanthipeptide(s) for K8B35_RS01370

K8B35_RS01365

Leader:

MKKDMVKKASGFIEEDELISLANGDNATGG

Core:

ATPATVVLTATIGLTGTTFTVTLSAASCPTSACTKQCNK

Core with dehydrations:

ADhbPADhbVVLDhbADhbIGLDhbGDhbDhbFDhbVDhbLDhaAADhaCysPDhbDhaACysDhbKQCysNK

antiSMASH-DB 4.0 matches for K8B35_RS01365

100.0%

NZ_CP033054.1and 11 others:

NZ_CP033054.1 Lanthipeptides: D9777_RS18840_lanthipeptideNZ_CP047268.1 Lanthipeptides: GKS41_RS18605_lanthipeptideNZ_CP047268.1 Lanthipeptides: GKS41_RS18605_lanthipeptideNZ_CP072563.1 Lanthipeptides: J6600_RS15935_lanthipeptideNZ_CP072563.1 Lanthipeptides: J6600_RS15935_lanthipeptideNZ_CP116014.1 Lanthipeptides: PF996_RS17885_lanthipeptideNZ_CP116014.1 Lanthipeptides: PF996_RS17885_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12560_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12560_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01365_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01365_lanthipeptide

Lanthipeptides: D9777_RS18840_lanthipeptide

1

ATPATVVLTATIGLTGTTFTVTLSAASCPTSACTKQCNK

39

ATPATVVLTATIGLTGTTFTVTLSAASCPTSACTKQCNK

1

ATPATVVLTATIGLTGTTFTVTLSAASCPTSACTKQCNK

39

97.4%

NZ_CP017953.1and 15 others:

NZ_CP017953.1 Lanthipeptides: BAMY_RS16390_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptide

Lanthipeptides: BAMY_RS16390_lanthipeptide

1

ATPATVVLTATIGLTGTTFTVTLSAASCPTSACTKQCNK

39

ATP TVVLTATIGLTGTTFTVTLSAASCPTSACTKQCNK

1

ATP-TVVLTATIGLTGTTFTVTLSAASCPTSACTKQCNK

38

76.9%

NZ_JALAUA010000003.1and 1 other:

NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04870_lanthipeptide

Lanthipeptides: MOD32_RS04870_lanthipeptide

1

ATPATVVLTATIGLTGTTFTVTLSAASCPTSACTKQCNK

39

TP T +LTA LTGTTFTVTLSAASCPTSACT CNK

1

GTPVTAILTA---LTGTTFTVTLSAASCPTSACTNLCNK

36

with 112 more sequence matches

Only the first 10 are displayed here.

74.4%

NZ_CP047645.1and 5 others:

NZ_CP047645.1 Lanthipeptides: GSN02_RS17435_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptide

Lanthipeptides: GSN02_RS17435_lanthipeptide

1

ATPATVVLTATIGLTGTTFTVTLSAASCPTSACTKQCNK

39

TP T ++TA LTGTTFTVTLSAASCPTSACT CNK

1

GTPVTAIITA---LTGTTFTVTLSAASCPTSACTNLCNK

36

53.8%

NZ_CKMQ01000043.1and 8 others:

NZ_CKMQ01000043.1 Lanthipeptides: AE832_RS09950_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS02065_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS02065_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS01730_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS01730_lanthipeptideNZ_LR216041.1 Lanthipeptides: E0F00_RS05470_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05985_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05985_lanthipeptide

Lanthipeptides: AE832_RS09950_lanthipeptide

7

VLTATIGLTGTTFTVTLSAASCPTSACTKQCNK

39

++ ATI G TFTVTL+A +CPTS CTK CNK

5

IIPATISFVGVTFTVTLNAGACPTSGCTKSCNK

37

53.8%

NZ_PNGD01000001.1and 1 other:

NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00165_lanthipeptide

Lanthipeptides: CJ239_RS00165_lanthipeptide

7

VLTATIGLTGTTFTVTLSAASCPTSACTKQCNK

39

++ ATI G TFTVTL+A +CPTS CTK CNK

5

IIAATISFAGVTFTVTLNAGACPTSGCTKSCNK

37

46.2%

NZ_BLIS01000009.1and 1 other:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptide

Lanthipeptides: GVO03_RS04825_lanthipeptide

1

ATPATVVLTATIGLTGTTFTVTLSAASCPTSACTKQC

37

A+PAT T IG T +SA +CPTSACT+ C

4

ASPATP-YTPAIGKGVIAVTAFVSANTCPTSACTRAC

39

46.2%

NZ_CP009288.1and 3 others:

NZ_CP009288.1 Lanthipeptides: PDUR_RS29295_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptide

Lanthipeptides: PDUR_RS29295_lanthipeptide

3

PATVVLTATIGLTGTTFTVTLSAASCPTSACTKQC

37

P T +LT T T T VT+SA+ CPT+ CT QC

6

PETTILT-TSSWTCITAGVTVSASLCPTTKCTSQC

39

46.2%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09625_lanthipeptide

Lanthipeptides: CQS04_RS09625_lanthipeptide

1

ATPATVVLTATIGLTGTTFTVTLSAASCPTSACTKQC

37

ATP T+V+TA G +SA SCPT+ACT+ C

1

ATP-TIVITAITGY--------ISANSCPTTACTRAC

28

46.2%

NZ_QRWZ01000002.1and 3 others:

NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide

Lanthipeptides: DWX18_RS02625_lanthipeptide

2

TPATVVLTATIGLTGTTFTVTLSAASCPTSACTKQC

37

TPAT T IG T +SA +CPTSACT+ C

2

TPATP-YTPAIGKGVIAVTAFVSANTCPTSACTRAC

36

43.6%

NZ_WHOM01000078.1and 1 other:

NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29290_lanthipeptide

Lanthipeptides: GCN81_RS29290_lanthipeptide

8

LTATIGLTGTTFTVTLSAA---SCPTSACTKQC

37

+T TI L T V SAA CPTS CTK+C

8

ITPTI-LPATGVIVGASAALQGGCPTSGCTKRC

39

41.0%

NZ_CP102975.1and 1 other:

NZ_FMOE01000002.1 Lanthipeptides: BJT27_RS07810_lanthipeptide

Lanthipeptides: NW953_RS00175_lanthipeptide

1

ATPATVVLTATIGLTGTTFTVTLSAASCPTSACTKQCNK

39

ATPA V+ T V S A CPT AC+ +C K

1

ATPAVVI---------TGILVAASTAQCPTLACSSRCGK

30

41.0%

NZ_JAENHN010000066.1and 1 other:

NZ_JAENHN010000066.1 Lanthipeptides: JHL18_RS24400_lanthipeptide

Lanthipeptides: JHL18_RS24400_lanthipeptide

1

ATPATVVLTATIGLTGTTFTVTLSAASCPTSACTKQCN

38

TP V+ AT+GLT T A C T ACT C+

2

GTPCAVI--ATVGLTIKVAT----AVVCETGACTGYCH

33

MIBiG 4.0 matches for K8B35_RS01365

25.6%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

21

VTLSAASCPTSACTKQC

37

V +SAA CPT+ CT +C

21

VGVSAAFCPTTKCTSRC

37

15.4%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

28

CPTSACTKQC

37

CPT+ CT +C

17

CPTTKCTSKC

26

12.8%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

15

TGTTFTVTLSAASCPTS

31

TG + A+C S

13

TGALMGCNMKTATCHCS

29

K8B35_RS01375

Leader:

MKKTKILKTPELKVTKDLNLIDPCGDVLEEIKEHEVSGA

Core:

FNTWNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

Core with dehydrations:

FNDhbWNDhbDhbDhbDhbDhaLGGILVDhaEVLGNKGKVCysDhbGDhbKECysQGDhbCys

antiSMASH-DB 4.0 matches for K8B35_RS01375

100.0%

NZ_CP017953.1and 27 others:

NZ_CP017953.1 Lanthipeptides: BAMY_RS16400_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptideNZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptideNZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptideNZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptideNZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptideNZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptideNZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptideNZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptideNZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptide

Lanthipeptides: BAMY_RS16400_lanthipeptide

1

FNTWNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

FNTWNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

1

FNTWNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

91.9%

NZ_CP047645.1and 7 others:

NZ_CP047645.1 Lanthipeptides: GSN02_RS17445_lanthipeptideNZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04860_lanthipeptideNZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04860_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18560_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18560_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03725_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03725_lanthipeptide

Lanthipeptides: GSN02_RS17445_lanthipeptide

1

FNTWNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

FNTWNTTTTS+G ILVSEV GNKGKVCTGTKECQGTC

1

FNTWNTTTTSVGTILVSEVFGNKGKVCTGTKECQGTC

37

60.5%

NZ_CM000756.1and 7 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS34475_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide

Lanthipeptides: BTHUR0011_RS34475_lanthipeptide

1

FNTWNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

NTWNTT TS I++SE GNKGKVCT T EC C

1

INTWNTTATSTS-IIISETFGNKGKVCTYTVECVNNC

36

with 110 more sequence matches

Only the first 10 are displayed here.

56.8%

NZ_JAGKQT010000007.1and 3 others:

NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09860_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide

Lanthipeptides: J2M30_RS09860_lanthipeptide

2

NTWNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

NTWNT +TS I VS +GN GKVCT T EC C

1

NTWNTISTSTC-IAVSHFVGNDGKVCTYTVECVNNC

35

54.1%

NZ_CP009288.1and 3 others:

NZ_CP009288.1 Lanthipeptides: PDUR_RS25150_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide

Lanthipeptides: PDUR_RS25150_lanthipeptide

5

NTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

NT TTS IL+S LGN G VCT TKEC +C

4

NTLTTS-TSILISMTLGNNGWVCTATKECMPSC

35

51.3%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide

Lanthipeptides: MT347_RS12955_lanthipeptide

4

WNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

W TT TSL VS V GN G+VCT T ECQ C

5

WTTTITSLTCYGVSWVAGNNGQVCTATVECQNNC

38

48.6%

NZ_CP009280.1and 1 other:

NZ_CP009280.1 Lanthipeptides: P40081_RS01820_lanthipeptide

Lanthipeptides: P40081_RS01820_lanthipeptide

5

NTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

NT TTS I +S LGN G VCT +KEC +C

4

NTLTTSTS-IFISRGLGNDGWVCTWSKECMPSC

35

48.6%

NZ_GG657757.1and 1 other:

NZ_GG657757.1 Lanthipeptides: SSQG_RS20730_lanthipeptide

Lanthipeptides: SSQG_RS20730_lanthipeptide

3

TWNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

+ N TT SL GI GN G CT TKECQ +C

3

SANFTTFSLSGIF-----GNDGDCCTLTKECQASC

32

48.6%

NZ_KL997439.1and 1 other:

NZ_KL997439.1 Lanthipeptides: IQ62_RS47105_lanthipeptide

Lanthipeptides: IQ62_RS47105_lanthipeptide

3

TWNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

+ NTTT +L S LG+KG CT TKECQ +C

3

SLNTTTFTL-----SAQLGDKGDCCTATKECQPSC

32

47.4%

NZ_WHOM01000078.1and 1 other:

NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptide

Lanthipeptides: GCN81_RS29300_lanthipeptide

4

WNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

W TT +SL S VLGN G CT T ECQ C

4

WGTTLSSLSCYGASYVLGNNGNFCTATAECQSNC

37

45.9%

NZ_QKTG01000020.1and 1 other:

NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide

Lanthipeptides: DEI99_RS16920_lanthipeptide

6

TTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

TT T+L VS LGN G CT T ECQ C

5

TTVTTLSCYGVSWALGNDGNFCTATVECQSNC

36

45.9%

NZ_WITJ01000001.1and 1 other:

NZ_WITJ01000001.1 Lanthipeptides: GHI93_RS00065_lanthipeptide

Lanthipeptides: GHI93_RS00065_lanthipeptide

3

TWNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

TWN +S+ V+ LGN G VCT T ECQ C

3

TWNLVFSSV----VTLALGNNGYVCTWTHECQANC

33

44.7%

NZ_BMRY01000003.1and 24 others:

NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide

Lanthipeptides: IE140_RS12370_lanthipeptide

4

WNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

W T +SL S VLGN G CT T ECQ C

4

WGTIVSSLSCYGASYVLGNNGNFCTATAECQNNC

37

MIBiG 4.0 matches for K8B35_RS01375

35.1%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

16

VSEVLGNKGKVCTGTKECQGTC

37

+S LGN G CT TKECQ C

8

LSNALGNNGGWCTLTKECQPNC

29

32.4%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

16

VSEVLGNKGKVCTGTKECQGTC

37

+S LGNKG CT T EC +C

6

ISCRLGNKGAYCTLTVECMPSC

27

17.9%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

27

CTGTKECQGTC

37

CT +KECQ C

28

CTLSKECQPNC

38

allorf_273844_274074

Leader:

MVLSDRNAIMKADKGRGRTPFPFFHENRLSESAGL

Core:

LQNVRVLKFPRHFRFLSRLPWLRRRSAPCPEAAICPAAEAS

Core with dehydrations:

LQNVRVLKFPRHFRFLDhaRLPWLRRRDhaAPCysPEAAICysPAAEADha

antiSMASH-DB 4.0 matches for allorf_273844_274074

100.0%

NZ_CP017953.1and 12 others:

NZ_CP021011.1 Lanthipeptides: allorf_1239450_1239680_lanthipeptideNZ_CP033054.1 Lanthipeptides: allorf_3724234_3724464_lanthipeptideNZ_CP041784.1 Lanthipeptides: allorf_3263499_3263729_lanthipeptideNZ_CP047268.1 Lanthipeptides: allorf_3744242_3744472_lanthipeptideNZ_CP048002.1 Lanthipeptides: allorf_1130609_1130839_lanthipeptideNZ_CP072563.1 Lanthipeptides: allorf_3274357_3274587_lanthipeptideNZ_CP097784.1 Lanthipeptides: allorf_3221763_3221993_lanthipeptideNZ_CP116014.1 Lanthipeptides: allorf_3479615_3479845_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: allorf_316050_316280_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: allorf_123482_123712_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: allorf_273844_274074_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: allorf_316397_316627_lanthipeptide

Lanthipeptides: allorf_3287857_3288087_lanthipeptide

1

LQNVRVLKFPRHFRFLSRLPWLRRRSAPCPEAAICPAAEAS

41

LQNVRVLKFPRHFRFLSRLPWLRRRSAPCPEAAICPAAEAS

1

LQNVRVLKFPRHFRFLSRLPWLRRRSAPCPEAAICPAAEAS

41

31.7%

NZ_CP011020.1:

Lanthipeptides: allorf_1818981_1819088_lanthipeptide

16

LSRLPWLRRRSAPC-----PEAAICPA

37

L+RL + RRS P AAICPA

1

LARLCFGLRRSLPVRHGQRQNAAICPA

27

19.5%

NZ_FOYL01000002.1:

Lanthipeptides: allorf_0629623_0629850_lanthipeptide

17

SRLPWLRRRSAPC

29

SR W+R RS PC

14

SRATWVRMRSGPC

26

with 2 more sequence matches

14.3%

NZ_BNCA01000011.1:

Lanthipeptides: allorf_160997_161218_lanthipeptide

20

PWLRRRSAPCPEAAICP

36

P R+ PCP A CP

37

PPDRQPPGPCPPAGSCP

53

13.5%

NZ_JAHTIK010000001.1:

Lanthipeptides: allorf_2154999_2155214_lanthipeptide

19

LPWLRRRSAPCP

30

LPW R PCP

2

LPWRMRDGGPCP

13

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.53 out of 26.06

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.56 out of 27.78

Confidence: medium

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 29.41 out of 36.54

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.20 out of 26.06

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.71 out of 20.97

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.98 out of 18.16

Confidence: strong

Additional weak hits (8):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.22 out of 28.14

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.83 out of 26.12

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.01 out of 28.14

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.87 out of 27.55

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.14 out of 30.22

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.73 out of 29.65

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.66 out of 32.93

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 19.59 out of 30.12

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

K8B35_RS01365 - Class II

Cleavage pHMM score: -5.10

RODEO score: 0

Monoisotopic mass: 3576.9 Da

Molecular weight: 3579.1 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3597.1 Da N = 1; 3615.2 Da N = 2; 3633.2 Da N = 3; 3651.2 Da N = 4; 3669.2 Da N = 5; 3687.2 Da N = 6; 3705.3 Da N = 7; 3723.3 Da N = 8; 3741.3 Da N = 9; 3759.3 Da N = 10; 3777.3 Da N = 11

K8B35_RS01375 - Class II

Cleavage pHMM score: -3.20

RODEO score: 0

Monoisotopic mass: 3666.9 Da

Molecular weight: 3669.1 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3687.1 Da N = 1; 3705.2 Da N = 2; 3723.2 Da N = 3; 3741.2 Da N = 4; 3759.2 Da N = 5; 3777.2 Da N = 6; 3795.3 Da N = 7

allorf_273844_274074 - Class II

Cleavage pHMM score: -5.70

RODEO score: 0

Monoisotopic mass: 4704.6 Da

Molecular weight: 4707.5 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4725.5 Da N = 1

K8B35_RS01365 - Class II

Cleavage pHMM score: -5.10

RODEO score: 0

Monoisotopic mass: 3576.9 Da

Molecular weight: 3579.1 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3597.1 Da N = 1; 3615.2 Da N = 2; 3633.2 Da N = 3; 3651.2 Da N = 4; 3669.2 Da N = 5; 3687.2 Da N = 6; 3705.3 Da N = 7; 3723.3 Da N = 8; 3741.3 Da N = 9; 3759.3 Da N = 10; 3777.3 Da N = 11

K8B35_RS01375 - Class II

Cleavage pHMM score: -3.20

RODEO score: 0

Monoisotopic mass: 3666.9 Da

Molecular weight: 3669.1 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3687.1 Da N = 1; 3705.2 Da N = 2; 3723.2 Da N = 3; 3741.2 Da N = 4; 3759.2 Da N = 5; 3777.2 Da N = 6; 3795.3 Da N = 7

allorf_252303_252449 - Class II

Cleavage pHMM score: -6.60

RODEO score: 0

Monoisotopic mass: 2366.3 Da

Molecular weight: 2367.9 Da

Number of bridges: 2

allorf_252335_252418 - Class II

Cleavage pHMM score: -6.80

RODEO score: 0

Monoisotopic mass: 1281.7 Da

Molecular weight: 1282.5 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1300.5 Da N = 1

allorf_273844_274074 - Class II

Cleavage pHMM score: -5.70

RODEO score: 0

Monoisotopic mass: 4704.6 Da

Molecular weight: 4707.5 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4725.5 Da N = 1

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
HgtR	Hydrogen-dependent regulator
MogR	Repressor of flagellar motility genes

NZ_JAIONG010000002.1 - Region 1 - NRPS,T3PKS,transAT-PKS

Download region GenBank file

Download region SVG

Location: 162,050 - 272,134 nt. (total: 110,085 nt) Show pHMM detection rules used

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

K8B35_RS02765: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

K8B35_RS02865: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

K8B35_RS02885: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: acylase

K8B35_RS02825: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

K8B35_RS02830: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

K8B35_RS02835: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: hydrolase protease

K8B35_RS02745: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

K8B35_RS02820: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

K8B35_RS02905: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: hydratase

K8B35_RS02850: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

K8B35_RS02855: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

K8B35_RS02770: 8-amino-7-oxononanoate synthase

smcogs: SMCOG1109: 8-amino-7-oxononanoate synthase

K8B35_RS02845: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

K8B35_RS02860: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

K8B35_RS02870: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

K8B35_RS02875: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

K8B35_RS02880: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001089.5	1.66	NRPS, PKS	bacillaene	Bacillus velezensis FZB42
BGC0001160.5	1.03	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0002135.2	1.03	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001132.4	0.97	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001135.5	0.97	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.4	0.96	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.96	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.95	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.94	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.91	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001089.5	0.91	NRPS, PKS	bacillaene	Bacillus velezensis FZB42
BGC0002135.2	0.70	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001132.4	0.69	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.69	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.68	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.68	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.67	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001758.4	0.66	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.65	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.50 out of 27.78

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.78 out of 20.97

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.62 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.79 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.14 out of 27.78

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.47 out of 21.55

Confidence: strong

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.57 out of 25.31

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.14 out of 18.16

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.60 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.29 out of 27.78

Confidence: medium

Additional weak hits (19):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.51 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.96 out of 26.06

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.16 out of 32.74

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.90 out of 29.25

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.22 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.08 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.45 out of 26.06

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.59 out of 39.62

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.06 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.67 out of 26.06

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.04 out of 30.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.39 out of 30.25

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.54 out of 36.54

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.38 out of 28.14

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.53 out of 30.25

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.62 out of 32.93

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.08 out of 39.62

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.11 out of 33.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 162049 - 272134:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (fatty_acid - Gly - ccmal - ohmal - mal) + (ccmal - mal - ohmal - mal) + (Me-ccmal - ohmal) + (Ala - ccmal - ccmal - Me-ccmal) + (mal - mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

K8B35_RS02825: mal

PKS_AT (4..285): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 100.0
inactive: 46.8
Methoxymalonyl-CoA: 38.9
Methylmalonyl-CoA: 25.3
Propionyl-CoA: 23.1
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

K8B35_RS02830: mal

PKS_AT (7..293): mal

ATSignature: (unknown)

No matches above 50%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 36.5
inactive: 26.2
Methoxymalonyl-CoA: 14.3
Benzoyl-CoA: 13.9
Methylmalonyl-CoA: 9.2
Isobutyryl-CoA: 8.8
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

K8B35_RS02835: mal

PKS_AT (4..282): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 88.0
inactive: 28.1
Methoxymalonyl-CoA: 24.5
Methylmalonyl-CoA: 12.2
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

K8B35_RS02860: fatty_acid - Gly

Search NORINE for peptide: strict or relaxed

CAL_domain (74..476): fatty_acid

minowa: fatty_acid

Prediction, score:

fatty_acid: 26.0
NH2: 9.4
shikimic_acid: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

AMP-binding (1145..1540): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FSMTFDIAALELQALCGGEWNMFGPTETTIWSAV
Nearest Stachelhaus code(s):: Gly DILQLGMIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

K8B35_RS02875: Ala

Search NORINE for peptide: strict or relaxed

AMP-binding (492..896): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: TFLTFDVSISEGNFMVAGEENIYGPTETSIYAAY
Nearest Stachelhaus code(s):: Ala DVSNMAIIYK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
ArcA	Repressor of carbon oxidation
CatR	H2O2-responsive repressor
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis

NZ_JAIONG010000003.1 - Region 1 - T3PKS

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Location: 91,741 - 132,841 nt. (total: 41,101 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

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MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acetyltransferase methyltransferase

K8B35_RS03745: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

K8B35_RS03755: isoprenylcysteine carboxyl methyltransferase

smcogs: SMCOG1150: isoprenylcysteine carboxyl methyltransferase

Hydrolases: hydrolase

K8B35_RS03725: isochorismatase

smcogs: SMCOG1027: isochorismatase

Ligases: synthase

K8B35_RS03750: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.55	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3	0.54	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0002332.2	0.44	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0001475.4	0.43	terpene	aspterric acid	Aspergillus terreus NIH2624
BGC0001289.5	0.35	ribosomal	penisin	Paenibacillus ehimensis
BGC0001647.3	0.34	PKS	lagunapyrone A, lagunapyrone B, lagunapyrone C	Streptomyces sp. MP131-18
BGC0002254.3	0.33	PKS	notoamide F, (+)-semivioxanthin, waikikiamide B, waikikiamide C, notoamide A, waikikiamide A	Aspergillus sp. FM242
BGC0001964.2	0.33	PKS	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium
BGC0001663.3	0.32	PKS	merocyclophane C, merocyclophane D	Nostoc sp. UIC 10110
BGC0001928.2	0.32	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.55	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3	0.54	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0002332.2	0.44	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0001475.4	0.43	terpene	aspterric acid	Aspergillus terreus NIH2624
BGC0001289.5	0.35	ribosomal	penisin	Paenibacillus ehimensis
BGC0001647.3	0.34	PKS	lagunapyrone A, lagunapyrone B, lagunapyrone C	Streptomyces sp. MP131-18
BGC0002254.3	0.33	PKS	notoamide F, (+)-semivioxanthin, waikikiamide B, waikikiamide C, notoamide A, waikikiamide A	Aspergillus sp. FM242
BGC0001964.2	0.33	PKS	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium
BGC0001663.3	0.32	PKS	merocyclophane C, merocyclophane D	Nostoc sp. UIC 10110
BGC0001928.2	0.32	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.75 out of 18.57

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.60 out of 26.06

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.26 out of 29.38

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.98 out of 20.97

Confidence: strong

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.80 out of 26.33

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.39 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.06 out of 26.06

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.67 out of 21.55

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.26 out of 27.78

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.84 out of 29.38

Confidence: medium

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.15 out of 18.46

Confidence: medium

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.73 out of 29.25

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 25.16 out of 28.19

Confidence: strong

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.10 out of 32.93

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.27 out of 28.19

Confidence: medium

Additional weak hits (10):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.18 out of 25.75

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.65 out of 30.25

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.01 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.58 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.23 out of 29.38

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 23.07 out of 30.22

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.01 out of 24.78

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.96 out of 29.65

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.45 out of 29.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.45 out of 26.06

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
ArcA	Repressor of carbon oxidation
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
RpoN	Regulator of nitrogen assimilation and virulence
SypG	Regulator of biofilm formation and host colonization
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_JAIONG010000003.1 - Region 2 - terpene

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Location: 212,554 - 234,437 nt. (total: 21,884 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

K8B35_RS04450: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Hydrolases: hydrolase

K8B35_RS04425: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002173.2	0.46	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0001535.3	0.42	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0000313.4	0.36	NRPS	beauvericin	Beauveria bassiana
BGC0002255.3	0.33	PKS	lijiquinone	Ascomycota sp. F53
BGC0000663.5	0.30	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000686.3	0.30	terpene	helvolic acid	Aspergillus fumigatus Af293
BGC0001575.4	0.29	NRPS	PZN5, PZN6, PZN7, PZN9, PZN10, PZN11	Ruminococcus sp. 5_1_39BFAA
BGC0001338.4	0.28	PKS	citrinin	Monascus ruber
BGC0000154.4	0.28	PKS	stipitatic acid	Talaromyces stipitatus ATCC 10500
BGC0001739.3	0.28	other (other)	phosphonoacetic Acid	Streptomyces sp. NRRL F-525

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002173.2	0.46	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0001535.3	0.42	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0000313.4	0.36	NRPS	beauvericin	Beauveria bassiana
BGC0002255.3	0.33	PKS	lijiquinone	Ascomycota sp. F53
BGC0000663.5	0.30	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000686.3	0.30	terpene	helvolic acid	Aspergillus fumigatus Af293
BGC0001575.4	0.29	NRPS	PZN5, PZN6, PZN7, PZN9, PZN10, PZN11	Ruminococcus sp. 5_1_39BFAA
BGC0001338.4	0.28	PKS	citrinin	Monascus ruber
BGC0000154.4	0.28	PKS	stipitatic acid	Talaromyces stipitatus ATCC 10500
BGC0001739.3	0.28	other (other)	phosphonoacetic Acid	Streptomyces sp. NRRL F-525

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

K8B35_RS04445: T2TS

Domain 1 (5 - 625): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.53 out of 26.06

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 26.30 out of 27.78

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.86 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19

Confidence: medium

Additional weak hits (5):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.63 out of 25.75

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.14 out of 39.62

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.54 out of 26.06

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.10 out of 29.25

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.62 out of 21.55

Confidence: weak

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_JAIONG010000004.1 - Region 1 - NRPS,betalactone,transAT-PKS

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Location: 1 - 80,319 nt. (total: 80,319 nt) Show pHMM detection rules used

Region on contig edge.

betalactone: (HMGL-like and AMP-binding)
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

K8B35_RS04725: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

K8B35_RS04800: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

K8B35_RS04820: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

K8B35_RS04925: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acylase aminotransferase carboxylase transferase

K8B35_RS04735: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

K8B35_RS04755: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

K8B35_RS04765: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

K8B35_RS04780: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

K8B35_RS04825: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Lyases: hydratase

K8B35_RS04750: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

K8B35_RS04730: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

K8B35_RS04745: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

K8B35_RS04785: 8-amino-7-oxononanoate synthase

smcogs: SMCOG1109: 8-amino-7-oxononanoate synthase

K8B35_RS04830: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

K8B35_RS04835: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

K8B35_RS04840: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001090.5	1.20	NRPS, PKS	bacillomycin D	Bacillus velezensis FZB42
BGC0001098.5	1.19	NRPS, PKS	iturin	Bacillus subtilis
BGC0000402.4	0.99	NRPS	paenilarvin A, paenilarvin B, paenilarvin C	Paenibacillus larvae subsp. larvae DSM 25430
BGC0002135.2	0.86	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001833.4	0.81	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001133.4	0.76	NRPS	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.76	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.75	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002286.3	0.75	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.75	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001090.5	0.85	NRPS, PKS	bacillomycin D	Bacillus velezensis FZB42
BGC0001098.5	0.84	NRPS, PKS	iturin	Bacillus subtilis
BGC0000402.4	0.80	NRPS	paenilarvin A, paenilarvin B, paenilarvin C	Paenibacillus larvae subsp. larvae DSM 25430
BGC0001103.5	0.77	NRPS, PKS	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001833.4	0.74	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.72	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.72	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132.4	0.72	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 20.32 out of 20.97

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.55 out of 18.46

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.29 out of 27.55

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.83 out of 28.19

Confidence: medium

Additional weak hits (5):

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.44 out of 20.47

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.74 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.11 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.52 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.10 out of 29.38

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 80319:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (fatty_acid - mal - Asn - D-Tyr) + (D-Asn - Ser - Glu - D-Ser) + (Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 3036 - 80319:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (fatty_acid - mal - Asn - D-Tyr) + (D-Asn - Ser - Glu - D-Ser) + (Thr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

K8B35_RS04730: X

AMP-binding (12..445): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: NNIVF-GCVLGAHGIMAGSTIAYGQTEASPVITQ
Nearest Stachelhaus code(s):: Z-ahmohOrn FGLHIASTCK (56% 8Å match); Ile DGLFIGIPVK (32% 8Å match)
Stachelhaus code match:: 60% (weak)

K8B35_RS04825: mal

PKS_AT (6..290): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 79.7
inactive: 29.9
Methoxymalonyl-CoA: 21.9
Methylmalonyl-CoA: 13.0
Propionyl-CoA: 11.7
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

K8B35_RS04830: fatty_acid - Asn

Search NORINE for peptide: strict or relaxed

CAL_domain (36..478): fatty_acid

minowa: fatty_acid

Prediction, score:

fatty_acid: 621.2
NH2: 18.0
shikimic_acid: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

AMP-binding (2956..3351): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: YWASFDLTVTSTKLIVGGEFNEYGPTEAVVGCMI
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

K8B35_RS04835: Tyr - Asn - Ser - Glu

Search NORINE for peptide: strict or relaxed

AMP-binding (268..662): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: SWKYFDAFILNGSTVVGGENNEYGPTENSVVSTF
Nearest Stachelhaus code(s):: Tyr DALSVGEVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1779..2174): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: YWASFDLTVTSTKLIVGGECNEYGPTETVVGCMI
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3287..3694): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWEWHFFASGEINLYGPTEATVDVSY
Nearest Stachelhaus code(s):: Ser DVWHFSLVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4336..4743): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: gln (Gln)

Stachelhaus prediction details:

Stachelhaus sequence:: LGLAFDASVKQADGLIGGETNVYGPTETCVDASV
Nearest Stachelhaus code(s):: Glu DAKDLGVVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

K8B35_RS04840: Ser - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (267..674): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWEWHFFASGEINLYGPTEATIDVSY
Nearest Stachelhaus code(s):: Ser DVWHFSLIDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1789..2188): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LNNHFDFSVWEGNQIFGGEINMYGITETTVHVTY
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
GnfM	Regulator of nitrogen-fixation genes
RpoN	Regulator of nitrogen assimilation and virulence
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_JAIONG010000007.1 - Region 1 - terpene-precursor

Download region GenBank file

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Location: 182,464 - 203,354 nt. (total: 20,891 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carboxylase

K8B35_RS09700: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase

K8B35_RS09730: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

K8B35_RS09735: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000638.3	0.37	terpene	carotenoid	Pantoea ananatis
BGC0000640.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC404

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000638.3	0.37	terpene	carotenoid	Pantoea ananatis
BGC0000640.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC404

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

K8B35_RS09730: PT_FPPS_like

Domain 1 (33 - 296): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.59 out of 30.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.14 out of 27.78

Confidence: medium

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.81 out of 29.25

Confidence: medium

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
SypG	Regulator of biofilm formation and host colonization

NZ_JAIONG010000008.1 - Region 1 - PKS-like

Download region GenBank file

Download region SVG

Location: 66,462 - 107,706 nt. (total: 41,245 nt) Show pHMM detection rules used

PKS-like: (t2pks2 or ksIII)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

K8B35_RS10290: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acyltransferase aminotransferase

K8B35_RS10245: aminotransferase

smcogs: SMCOG1019: aminotransferase

K8B35_RS10260: acyltransferase

smcogs: SMCOG1141: acyltransferase

Hydrolases: deacetylase

K8B35_RS10200: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

Ligases: synthase

K8B35_RS10240: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Translocases: permease

K8B35_RS10285: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.55	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001928.2	0.50	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002404.2	0.45	other (other)	falcarindiol	Solanum lycopersicum
BGC0000205.3	0.43	PKS	bryostatin	Candidatus Endobugula sertula
BGC0002150.2	0.42	ribosomal	triculamin	Streptomyces triculaminicus
BGC0002151.2	0.42	ribosomal	alboverticillin	Streptomyces griseocarneus
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001206.5	0.42	other (other)	indolmycin	Streptomyces griseus subsp. griseus
BGC0001292.5	0.42	other (other)	A33853	Streptomyces sp. NRRL 12068

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.55	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001928.2	0.50	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002404.2	0.45	other (other)	falcarindiol	Solanum lycopersicum
BGC0000205.3	0.43	PKS	bryostatin	Candidatus Endobugula sertula
BGC0002150.2	0.42	ribosomal	triculamin	Streptomyces triculaminicus
BGC0002151.2	0.42	ribosomal	alboverticillin	Streptomyces griseocarneus
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001206.5	0.42	other (other)	indolmycin	Streptomyces griseus subsp. griseus
BGC0001292.5	0.42	other (other)	A33853	Streptomyces sp. NRRL 12068

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.52 out of 26.06

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 25.91 out of 27.55

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.88 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.01 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.75 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.35 out of 26.06

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.83 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.27 out of 28.19

Confidence: medium

Additional weak hits (9):

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.59 out of 30.11

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.75 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.28 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.97 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.28 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.48 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.02 out of 28.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.00 out of 33.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.32 out of 33.14

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM	Regulator of nitrogen-fixation genes
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_JAIONG010000009.1 - Region 1 - transAT-PKS

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Location: 13,034 - 101,264 nt. (total: 88,231 nt) Show pHMM detection rules used

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

K8B35_RS10875: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

K8B35_RS10885: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

K8B35_RS10890: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

K8B35_RS10900: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

K8B35_RS10930: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: acylase kinase

K8B35_RS10770: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

K8B35_RS10870: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: deacetylase deformylase hydrolase phosphatase

K8B35_RS10850: hydrolase

smcogs: SMCOG1179: hydrolase

K8B35_RS10855: peptide deformylase

smcogs: SMCOG1275: peptide deformylase

K8B35_RS10905: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

K8B35_RS10910: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

K8B35_RS10940: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

K8B35_RS10970: inositol monophosphatase

smcogs: SMCOG1207: inositol monophosphatase

Ligases: synthase

K8B35_RS10880: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

K8B35_RS10920: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000181.5	0.90	PKS	macrolactin H	Bacillus velezensis FZB42
BGC0001383.3	0.89	PKS	macrolactin H, macrolactin B, macrolactin 1c, macrolactin E	Jeotgalibacillus marinus
BGC0001534.3	0.70	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001244.3	0.64	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.64	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.64	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001160.5	0.63	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.63	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001284.4	0.63	PKS	alternariol	Parastagonospora nodorum SN15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000181.5	0.90	PKS	macrolactin H	Bacillus velezensis FZB42
BGC0001383.3	0.89	PKS	macrolactin H, macrolactin B, macrolactin 1c, macrolactin E	Jeotgalibacillus marinus
BGC0001534.3	0.70	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001244.3	0.64	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.64	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.64	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001160.5	0.63	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.63	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001284.4	0.63	PKS	alternariol	Parastagonospora nodorum SN15

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.63 out of 27.78

Confidence: strong

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.94 out of 21.55

Confidence: medium

Additional weak hits (7):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.30 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.56 out of 29.38

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.27 out of 30.22

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.35 out of 26.33

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.20 out of 31.73

Confidence: weak

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.44 out of 20.47

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.99 out of 33.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 13033 - 101264:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (ohmal - ccmal - ccmal) + (ccmal) + (ccmal - mal) + (ccmal - mal) + (ohmal) + (ohmal - mal)
Non-colinear ordering:: K8B35_RS10875 + K8B35_RS10880 + K8B35_RS10885 + K8B35_RS10890 + K8B35_RS10895 + K8B35_RS10900 + K8B35_RS10905

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

K8B35_RS10870: mal

PKS_AT (4..282): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 89.0
inactive: 33.0
Methoxymalonyl-CoA: 26.0
Methylmalonyl-CoA: 19.4
Propionyl-CoA: 16.1
fatty_acid: 13.9
trans-1,2-CPDA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ToxT	Regulator of MSHA biosynthesis

NZ_JAIONG010000010.1 - Region 1 - RiPP-like

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Location: 44,606 - 57,684 nt. (total: 13,079 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

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Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

K8B35_RS11485: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000617.5	0.50	ribosomal	coagulin	Bacillus coagulans
BGC0000558.5	0.49	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002579.2	0.48	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000624.3	0.46	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0000619.3	0.45	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.45	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0001388.3	0.45	ribosomal	gassericin E	Lactobacillus gasseri
BGC0001862.4	0.45	ribosomal	pallidocin	Aeribacillus pallidus
BGC0001864.3	0.44	ribosomal	listeriocytocin	Listeria monocytogenes SLCC2540

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000617.5	0.50	ribosomal	coagulin	Bacillus coagulans
BGC0000558.5	0.49	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002579.2	0.48	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000624.3	0.46	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0000619.3	0.45	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.45	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0001388.3	0.45	ribosomal	gassericin E	Lactobacillus gasseri
BGC0001862.4	0.45	ribosomal	pallidocin	Aeribacillus pallidus
BGC0001864.3	0.44	ribosomal	listeriocytocin	Listeria monocytogenes SLCC2540

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.03 out of 26.06

Confidence: medium

Additional weak hits (7):

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.59 out of 30.11

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.31 out of 25.88

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.53 out of 33.73

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.12 out of 30.25

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 24.12 out of 36.53

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.37 out of 30.98

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.31 out of 25.88

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes

NZ_JAIONG010000011.1 - Region 1 - other

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Location: 90,742 - 118,379 nt. (total: 27,638 nt) Show pHMM detection rules used

Region on contig edge.

other: (Neocarzinostat or bcpB or frbD or mitE or prnB or CaiA or bacilysin or orf2_PTase)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

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MIBiG comparison

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TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

K8B35_RS12425: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

K8B35_RS12460: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

K8B35_RS12480: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: aminotransferase transferase

K8B35_RS12370: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

K8B35_RS12395: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

K8B35_RS12475: aminotransferase

smcogs: SMCOG1019: aminotransferase

Lyases: dehydratase lyase

K8B35_RS12400: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

K8B35_RS12405: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

K8B35_RS12465: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Translocases: permease

K8B35_RS12435: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001184.4	0.97	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000888.5	0.97	other (other)	bacilysin	Bacillus sp. CS93
BGC0000898.5	0.56	saccharide	desosamine, pikromycin, neomethymycin, narbomycin	Streptomyces venezuelae
BGC0000773.3	0.54	saccharide	lipopolysaccharide	Escherichia coli
BGC0000794.5	0.53	saccharide	S-layer glycan	Geobacillus stearothermophilus
BGC0000790.3	0.53	saccharide	O-antigen	Escherichia coli
BGC0000791.3	0.53	saccharide	O-antigen	Cronobacter sakazakii
BGC0001817.5	0.52	other (other)	vancosamine	Streptomyces sp. WAC2288
BGC0000795.3	0.50	saccharide	S-layer glycan	Aneurinibacillus thermoaerophilus
BGC0000899.4	0.50	saccharide	desosamine	Streptomyces narbonensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001184.4	0.97	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000888.5	0.97	other (other)	bacilysin	Bacillus sp. CS93
BGC0000898.5	0.56	saccharide	desosamine, pikromycin, neomethymycin, narbomycin	Streptomyces venezuelae
BGC0000773.3	0.54	saccharide	lipopolysaccharide	Escherichia coli
BGC0000794.5	0.53	saccharide	S-layer glycan	Geobacillus stearothermophilus
BGC0000790.3	0.53	saccharide	O-antigen	Escherichia coli
BGC0000791.3	0.53	saccharide	O-antigen	Cronobacter sakazakii
BGC0001817.5	0.52	other (other)	vancosamine	Streptomyces sp. WAC2288
BGC0000795.3	0.50	saccharide	S-layer glycan	Aneurinibacillus thermoaerophilus
BGC0000899.4	0.50	saccharide	desosamine	Streptomyces narbonensis

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.48 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.12 out of 23.79

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.63 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.06 out of 27.78

Confidence: medium

Additional weak hits (10):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.93 out of 29.38

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.32 out of 26.06

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.66 out of 30.97

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.09 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.18 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.57 out of 26.06

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.32 out of 30.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.88 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.45 out of 26.06

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.68 out of 33.14

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
IolR	Regulator of the inositol catabolism
RpoN	Regulator of nitrogen assimilation and virulence
ToxT	Regulator of MSHA biosynthesis

NZ_JAIONG010000020.1 - Region 1 - transAT-PKS-like

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Location: 23,137 - 69,738 nt. (total: 46,602 nt) Show pHMM detection rules used

Region on contig edge.

transAT-PKS-like: cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS) and not PKS_AT)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

K8B35_RS16620: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

K8B35_RS16700: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

K8B35_RS16725: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

K8B35_RS16730: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

K8B35_RS16740: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

K8B35_RS16745: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: hydrolase

K8B35_RS16705: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

Lyases: hydratase

K8B35_RS16715: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: synthase

K8B35_RS16720: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

K8B35_RS16735: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000176.5	0.64	PKS	difficidin	Bacillus velezensis FZB42
BGC0001164.3	0.59	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001254.3	0.58	PKS	ACT-Toxin II	Alternaria alternata
BGC0000174.5	0.57	PKS	bryostatin	Candidatus Endobugula sertula
BGC0001795.3	0.53	PKS	swinholide A	Nostoc sp. UHCC 0450
BGC0001201.3	0.52	terpene	eremophilene	Sorangium cellulosum So ce56
BGC0001012.3	0.50	NRPS, PKS	meridamycin	Streptomyces violaceusniger
BGC0002056.3	0.49	NRPS, PKS	peloruside A	sponge metagenome
BGC0000255.5	0.48	PKS	pederin	Uncultured bacterium
BGC0000185.5	0.48	PKS	tartrolon D, tartrolon E	Teredinibacter turnerae T7901

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000176.5	0.64	PKS	difficidin	Bacillus velezensis FZB42
BGC0001164.3	0.59	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001254.3	0.58	PKS	ACT-Toxin II	Alternaria alternata
BGC0000174.5	0.57	PKS	bryostatin	Candidatus Endobugula sertula
BGC0001795.3	0.53	PKS	swinholide A	Nostoc sp. UHCC 0450
BGC0001201.3	0.52	terpene	eremophilene	Sorangium cellulosum So ce56
BGC0001012.3	0.50	NRPS, PKS	meridamycin	Streptomyces violaceusniger
BGC0002056.3	0.49	NRPS, PKS	peloruside A	sponge metagenome
BGC0000255.5	0.48	PKS	pederin	Uncultured bacterium
BGC0000185.5	0.48	PKS	tartrolon D, tartrolon E	Teredinibacter turnerae T7901

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.22 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.51 out of 23.79

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.89 out of 27.78

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.84 out of 24.78

Confidence: strong

Additional weak hits (5):

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 26.71 out of 30.97

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 22.13 out of 30.97

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.26 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.34 out of 26.06

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.13 out of 25.75

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 23136 - 69738:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (ohmal - ccmal) + (ohmal - mal) + (Me-ccmal) + (mal)
Non-colinear ordering:: K8B35_RS16745 + K8B35_RS16740 + K8B35_RS16735 + K8B35_RS16730

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
IolR	Regulator of the inositol catabolism
LexA variant 2	Repressor of DNA damage response
ToxT	Regulator of MSHA biosynthesis

NZ_JAIONG010000021.1 - Region 1 - NRPS

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Location: 1 - 55,299 nt. (total: 55,299 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase electron transfer oxidoreductase reductase

K8B35_RS16880: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

K8B35_RS16895: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

K8B35_RS16900: flavodoxin

smcogs: SMCOG1134: flavodoxin

K8B35_RS16905: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

K8B35_RS16920: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

Transferases: PPTase aminotransferase

K8B35_RS16795: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

K8B35_RS16800: aminotransferase

smcogs: SMCOG1019: aminotransferase

Hydrolases: esterase

K8B35_RS16805: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: ligase synthase

K8B35_RS16810: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

K8B35_RS16830: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

K8B35_RS16835: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

K8B35_RS16885: cobalamin synthesis protein/P47K family protein

smcogs: SMCOG1178: cobalamin synthesis protein/P47K family protein

K8B35_RS21620: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000433.5	0.82	NRPS	surfactin	Bacillus velezensis FZB42
BGC0001128.4	0.76	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.76	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.75	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001249.5	0.73	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001135.5	0.73	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000433.5	0.82	NRPS	surfactin	Bacillus velezensis FZB42
BGC0001128.4	0.76	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.76	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.75	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001249.5	0.73	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001135.5	0.73	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.76 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.50 out of 27.78

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.20 out of 30.25

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.40 out of 20.97

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.88 out of 23.79

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.55 out of 29.38

Confidence: medium

Additional weak hits (9):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.72 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.99 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.38 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.84 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.40 out of 26.06

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.74 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.89 out of 29.38

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.97 out of 30.98

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.50 out of 35.63

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 55299:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Glu - Leu - D-Leu) + (Val) + (Asp - D-Leu) + (Leu)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

K8B35_RS16810: Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (469..867): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: LHVSFDAFTFDAFALFGGEINCYGPTEGTVFATA
Nearest Stachelhaus code(s):: Leu DAFFLGCVFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

K8B35_RS21620: Asp - Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (437..839): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asp (Asp)

Stachelhaus prediction details:

Stachelhaus sequence:: YWFSFDLGYTAPKLVLGGEINHYGPTETTIGAIA
Nearest Stachelhaus code(s):: Asp DLTKVGHIGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1482..1871): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: LWHAFDASIWEPFLLVGGDVNNYGPTENTVVATS
Nearest Stachelhaus code(s):: Leu DAWFLGNVVK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

K8B35_RS16830: Val

Search NORINE for peptide: strict or relaxed

AMP-binding (180..574): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LHSGFDAGTFEGWLIIGGDWNGYGPTENTTFSTS
Nearest Stachelhaus code(s):: Val DAFWIGGTFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

K8B35_RS16835: Glu - Leu - Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (465..867): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: gln (Gln)

Stachelhaus prediction details:

Stachelhaus sequence:: LSLAFDASVKQADGLIGGETNVYGPTETCVDASV
Nearest Stachelhaus code(s):: Glu DAKDLGVVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1511..1908): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: TNTSFDAFMFDGMIMFGGELHMYGPSESTVFATY
Nearest Stachelhaus code(s):: Leu DAFMMGMVFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2550..2939): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: LWHAFDASIWEPFLLVGGDVNNYGPTENTVVATS
Nearest Stachelhaus code(s):: Leu DAWFLGNVVK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
FuR variant 1	Ferric Uptake Regulator
IolR	Regulator of the inositol catabolism
ToxT	Regulator of MSHA biosynthesis

NZ_JAIONG010000027.1 - Region 1 - transAT-PKS

Download region GenBank file

Download region SVG

Location: 1 - 34,356 nt. (total: 34,356 nt) Show pHMM detection rules used

Region on contig edge.

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

K8B35_RS18620: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

K8B35_RS18660: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

K8B35_RS18685: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

Transferases: acylase transferase

K8B35_RS18640: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

K8B35_RS18710: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Hydrolases: deacetylase

K8B35_RS18705: acetylornithine deacetylase

smcogs: SMCOG1247: acetylornithine deacetylase

Ligases: ligase

K8B35_RS18625: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.62	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0000176.5	0.51	PKS	difficidin	Bacillus velezensis FZB42
BGC0002056.3	0.50	NRPS, PKS	peloruside A	sponge metagenome
BGC0001928.2	0.48	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000205.3	0.47	PKS	bryostatin	Candidatus Endobugula sertula
BGC0001987.2	0.46	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0001197.5	0.46	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000913.3	0.45	other (other)	MK-8	Enterobacter cloacae
BGC0002212.3	0.44	PKS	Orsellinic acid	Moniliophthora roreri MCA 2997

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.62	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0000176.5	0.51	PKS	difficidin	Bacillus velezensis FZB42
BGC0002056.3	0.50	NRPS, PKS	peloruside A	sponge metagenome
BGC0001928.2	0.48	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000205.3	0.47	PKS	bryostatin	Candidatus Endobugula sertula
BGC0001987.2	0.46	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0001197.5	0.46	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000913.3	0.45	other (other)	MK-8	Enterobacter cloacae
BGC0002212.3	0.44	PKS	Orsellinic acid	Moniliophthora roreri MCA 2997

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.19 out of 27.78

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.30 out of 25.31

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.92 out of 27.78

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.93 out of 27.55

Confidence: medium

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.79 out of 21.84

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.78 out of 25.88

Confidence: medium

Additional weak hits (4):

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.46 out of 30.97

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.61 out of 30.25

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.89 out of 32.93

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.45 out of 26.06

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 34356:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-ccmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

K8B35_RS18625: X

AMP-binding (15..363): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: ALLLHIGGINTAPATYGTEKQTYGLTELGIFSTK
Nearest Stachelhaus code(s):: 2,3-dohHda IGNPTGTIMK (74% 8Å match)
Stachelhaus code match:: 90% (moderate)

K8B35_RS18640: mal

PKS_AT (4..281): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 87.7
inactive: 30.9
Methoxymalonyl-CoA: 29.3
Methylmalonyl-CoA: 21.7
Propionyl-CoA: 16.5
2-Methylbutyryl-CoA: 15.4
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM	Regulator of nitrogen-fixation genes
MexT	Global virulence regulator
PsrA	Oleic acid responsive regulator
ToxT	Regulator of MSHA biosynthesis

NZ_JAIONG010000033.1 - Region 1 - terpene

Download region GenBank file

Download region SVG

Location: 13,862 - 29,395 nt. (total: 15,534 nt) Show pHMM detection rules used

Region on contig edge.

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

K8B35_RS20065: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Hydrolases: hydrolase

K8B35_RS20040: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000885.3	0.46	other (other)	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000846.5	0.44	other (other)	tabtoxin	Pseudomonas syringae
BGC0001880.3	0.41	ribosomal	scytodecamide	Scytonema sp. UIC 10036
BGC0001374.5	0.38	other (other)	thienodolin	Streptomyces albogriseolus
BGC0002285.2	0.33	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0001810.3	0.33	PKS	trehangelin	Polymorphospora rubra
BGC0001735.5	0.33	other (other)	pentostatine, vidarabine	Streptomyces antibioticus
BGC0000720.3	0.33	saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0001007.5	0.32	NRPS, PKS	lymphostin, neolymphostinol B, lymphostinol, neolymphostin b	Salinispora arenicola CNS-205
BGC0000937.5	0.32	other (other)	fosfazinomycin A, fosfazinomycin B	Streptomyces sp. WM6372

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000885.3	0.46	other (other)	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000846.5	0.44	other (other)	tabtoxin	Pseudomonas syringae
BGC0001880.3	0.41	ribosomal	scytodecamide	Scytonema sp. UIC 10036
BGC0001374.5	0.38	other (other)	thienodolin	Streptomyces albogriseolus
BGC0002285.2	0.33	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0001810.3	0.33	PKS	trehangelin	Polymorphospora rubra
BGC0001735.5	0.33	other (other)	pentostatine, vidarabine	Streptomyces antibioticus
BGC0000720.3	0.33	saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0001007.5	0.32	NRPS, PKS	lymphostin, neolymphostinol B, lymphostinol, neolymphostin b	Salinispora arenicola CNS-205
BGC0000937.5	0.32	other (other)	fosfazinomycin A, fosfazinomycin B	Streptomyces sp. WM6372

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene		squalene	C30	acyclic	none
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none
triterpene		PSPP	C30	acyclic	PP
tetraterpene	C40 carotenoid	phytoene	C40	acyclic	none
triterpene		hydroxysqualene	C30	acyclic	OH

Genes with terpene domains:

K8B35_RS20045: PT_phytoene_like

Domain 1 (3 - 242): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → squalene; FPP → diapophytoene; FPP → PSPP; GGPP → phytoene; PSPP → hydroxysqualene

Transcription Factor Binding Sites

Binding sites found:

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.10 out of 26.85

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.88 out of 27.78

Confidence: medium

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 23.16 out of 26.33

Confidence: medium

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 26.99 out of 35.63

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.27 out of 28.19

Confidence: medium

Additional weak hits (3):

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.16 out of 26.06

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.44 out of 31.73

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
PP	Diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
NrtR	NAD synthesis repressor
RutR	Regulator of the pyrimidine and purine metabolism
ZuR variant 1	Zinc-responsive repressor

NZ_JAIONG010000036.1 - Region 1 - transAT-PKS-like

Download region GenBank file

Download region SVG

Location: 1 - 22,998 nt. (total: 22,998 nt) Show pHMM detection rules used

Region on contig edge.

transAT-PKS-like: cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS) and not PKS_AT)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthase

K8B35_RS20340: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

K8B35_RS20350: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000176.5	0.63	PKS	difficidin	Bacillus velezensis FZB42
BGC0001244.3	0.61	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.61	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.61	PKS	asperlactone	Aspergillus ochraceus
BGC0002191.2	0.61	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001275.3	0.60	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0002192.3	0.60	PKS	FR901512	fungal sp. No.14919
BGC0001164.3	0.59	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.59	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001795.3	0.58	PKS	swinholide A	Nostoc sp. UHCC 0450

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000176.5	0.63	PKS	difficidin	Bacillus velezensis FZB42
BGC0001244.3	0.61	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.61	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.61	PKS	asperlactone	Aspergillus ochraceus
BGC0002191.2	0.61	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001275.3	0.60	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0002192.3	0.60	PKS	FR901512	fungal sp. No.14919
BGC0001164.3	0.59	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.59	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001795.3	0.58	PKS	swinholide A	Nostoc sp. UHCC 0450

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (1):

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.88 out of 20.01

Confidence: weak

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 22998:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal) + (ohmal - mal) + (mal) + (ccmal)
Non-colinear ordering:: K8B35_RS20340 + K8B35_RS20345 + K8B35_RS20350 + K8B35_RS20355

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

TFBS definitions

Regulator	Description

NZ_JAIONG010000039.1 - Region 1 - NRPS

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Location: 1 - 18,628 nt. (total: 18,628 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: ligase

K8B35_RS20515: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

K8B35_RS20520: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.67	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000426.5	0.67	NRPS	sevadicin	Paenibacillus larvae
BGC0001833.4	0.67	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.66	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.66	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.66	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.65	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4	0.64	NRPS	taxlllaid A	Xenorhabdus bovienii SS-2004

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.67	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000426.5	0.67	NRPS	sevadicin	Paenibacillus larvae
BGC0001833.4	0.67	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.66	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.66	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.66	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.65	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4	0.64	NRPS	taxlllaid A	Xenorhabdus bovienii SS-2004

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.22 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

Additional weak hits (4):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.79 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.09 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.75 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.41 out of 29.38

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 18628:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ile)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

K8B35_RS20515: Ile

Search NORINE for peptide: strict or relaxed

AMP-binding (473..866): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: ile (Ile)

Stachelhaus prediction details:

Stachelhaus sequence:: LNSGFDAVTFEGFLYVGGEYNIYGPTENTTFSTF
Nearest Stachelhaus code(s):: Ile DAFFYGITFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

K8B35_RS20520: Glu

Search NORINE for peptide: strict or relaxed

AMP-binding (463..868): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: glu (Glu)

Stachelhaus prediction details:

Stachelhaus sequence:: FGMSFDASIWQWHFFAGGEIHGYGPTEATVDAAF
Nearest Stachelhaus code(s):: Glu DAWHFGGVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
ToxT	Regulator of MSHA biosynthesis

NZ_JAIONG010000040.1 - Region 1 - RiPP-like

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Location: 8,147 - 18,478 nt. (total: 10,332 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0001638.4	0.40	ribosomal	klebsazolicin	Klebsiella pneumoniae subsp. ozaenae
BGC0000504.5	0.35	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000551.5	0.35	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000500.5	0.35	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0002698.2	0.35	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002116.3	0.33	ribosomal	darobactin A	Photorhabdus khanii HGB 1456
BGC0000626.3	0.32	ribosomal	thuricin	Bacillus thuringiensis
BGC0000487.5	0.32	ribosomal	carnocyclin	Carnobacterium maltaromaticum
BGC0000538.3	0.32	ribosomal	nisin Z	Lactococcus lactis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0001638.4	0.40	ribosomal	klebsazolicin	Klebsiella pneumoniae subsp. ozaenae
BGC0000504.5	0.35	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000551.5	0.35	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000500.5	0.35	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0002698.2	0.35	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002116.3	0.33	ribosomal	darobactin A	Photorhabdus khanii HGB 1456
BGC0000626.3	0.32	ribosomal	thuricin	Bacillus thuringiensis
BGC0000487.5	0.32	ribosomal	carnocyclin	Carnobacterium maltaromaticum
BGC0000538.3	0.32	ribosomal	nisin Z	Lactococcus lactis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (1):

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.41 out of 36.53

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description