GCF_020138715.1 - 5 region(s) - antiSMASH results

Region	Type	From	To	Most similar known cluster
Region 1.1	cyclic-lactone-autoinducer	1,039,581	1,060,144
Region 1.2	cyclic-lactone-autoinducer	1,981,746	2,002,545
Region 1.3	terpene-precursor	2,255,378	2,276,250
Region 1.4	ranthipeptide	2,384,142	2,405,725

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	lanthipeptide-class-i	43,440	69,585

Region	Type	From	To
Region 1.1	cyclic-lactone-autoinducer	1,039,581	1,060,144
Region 1.2	cyclic-lactone-autoinducer	1,981,746	2,002,545
Region 1.3	terpene-precursor	2,255,378	2,276,250
Region 1.4	ranthipeptide	2,384,142	2,405,725
Region 2.1	lanthipeptide-class-i	43,440	69,585

NZ_CP075970.1 - Region 1 - cyclic-lactone-autoinducer

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Location: 1,039,581 - 1,060,144 nt. (total: 20,564 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0001427.4	0.29	NRPS, PKS	myxochromide A	Myxococcus xanthus
BGC0001423.4	0.29	NRPS, PKS	myxochromide C	Myxococcus hansupus
BGC0001425.4	0.29	NRPS, PKS	myxochromide A	Myxococcus xanthus DK 1622
BGC0001426.4	0.29	NRPS, PKS	myxochromide A	Myxococcus xanthus
BGC0001421.4	0.29	NRPS, PKS	myxochromide B	Myxococcus sp.
BGC0001428.4	0.29	NRPS, PKS	myxochromide A	Myxococcus xanthus
BGC0001424.4	0.29	NRPS, PKS	myxochromide C	Myxococcus virescens
BGC0001422.4	0.27	NRPS, PKS	myxochromide A	Myxococcus fulvus HW-1
BGC0000897.5	0.26	other (other)	dehydrophos	Streptomyces luridus
BGC0002060.3	0.22	PKS	secimide	Pseudomonas syringae pv. syringae B728a

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001427.4	0.29	NRPS, PKS	myxochromide A	Myxococcus xanthus
BGC0001423.4	0.29	NRPS, PKS	myxochromide C	Myxococcus hansupus
BGC0001425.4	0.29	NRPS, PKS	myxochromide A	Myxococcus xanthus DK 1622
BGC0001426.4	0.29	NRPS, PKS	myxochromide A	Myxococcus xanthus
BGC0001421.4	0.29	NRPS, PKS	myxochromide B	Myxococcus sp.
BGC0001428.4	0.29	NRPS, PKS	myxochromide A	Myxococcus xanthus
BGC0001424.4	0.29	NRPS, PKS	myxochromide C	Myxococcus virescens
BGC0001422.4	0.27	NRPS, PKS	myxochromide A	Myxococcus fulvus HW-1
BGC0000897.5	0.26	other (other)	dehydrophos	Streptomyces luridus
BGC0002060.3	0.22	PKS	secimide	Pseudomonas syringae pv. syringae B728a

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
IolR	Regulator of the inositol catabolism
SypG	Regulator of biofilm formation and host colonization
ZuR variant 1	Zinc-responsive repressor

NZ_CP075970.1 - Region 2 - cyclic-lactone-autoinducer

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Location: 1,981,746 - 2,002,545 nt. (total: 20,800 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0000645.3	0.35	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000648.3	0.34	terpene	carotenoid	Myxococcus xanthus
BGC0000334.4	0.29	NRPS	cyclosporin A	Tolypocladium inflatum NRRL 8044
BGC0002686.2	0.20	NRPS	madurastatin D1, madurastatin D2, (-)-Madurastatin C1	Actinomadura sp. WMMA1423

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000645.3	0.35	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000648.3	0.34	terpene	carotenoid	Myxococcus xanthus
BGC0000334.4	0.29	NRPS	cyclosporin A	Tolypocladium inflatum NRRL 8044
BGC0002686.2	0.20	NRPS	madurastatin D1, madurastatin D2, (-)-Madurastatin C1	Actinomadura sp. WMMA1423

Regulator	Description
FuR variant 1	Ferric Uptake Regulator
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes

NZ_CP075970.1 - Region 3 - terpene-precursor

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Location: 2,255,378 - 2,276,250 nt. (total: 20,873 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

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core biosynthetic genes

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transport-related genes

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.46	terpene	astallatene	Arabidopsis thaliana
BGC0002283.2	0.45	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.45	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000640.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000665.5	0.37	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000043.5	0.36	PKS	curacin A	Moorea producens 19L
BGC0000630.3	0.36	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000666.5	0.35	terpene	xiamycin A	Streptomyces sp. SCSIO 02999

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.46	terpene	astallatene	Arabidopsis thaliana
BGC0002283.2	0.45	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.45	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000640.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000665.5	0.37	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000043.5	0.36	PKS	curacin A	Moorea producens 19L
BGC0000630.3	0.36	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000666.5	0.35	terpene	xiamycin A	Streptomyces sp. SCSIO 02999

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

Regulator	Description
PerR	Peroxide regulator

NZ_CP075970.1 - Region 4 - ranthipeptide

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Location: 2,384,142 - 2,405,725 nt. (total: 21,584 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0002306.2	0.47	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0002407.3	0.36	other (other), saccharide	angustmycin A, angustmycin C	Streptomyces angustmyceticus
BGC0001387.5	0.35	other (other)	nucleocidin	Streptomyces calvus
BGC0001591.4	0.32	other (other)	fatty acid enol ester, N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0002621.2	0.32	other (other)	angustmycin A, angustmycin B, angustmycin C, aristeromycin, arabinofuranosyladenine	Streptomyces angustmyceticus
BGC0001155.5	0.31	ribosomal	GE2270	Planobispora rosea
BGC0000604.4	0.30	ribosomal	GE2270A	Nonomuraea sp. WU8817
BGC0002713.2	0.30	NRPS	mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D	Photorhabdus laumondii subsp. laumondii
BGC0000027.4	0.30	PKS	ankaflavin, monascin, rubropunctatine, monascorubrin	Monascus pilosus
BGC0001089.5	0.26	NRPS, PKS	bacillaene	Bacillus velezensis FZB42

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002306.2	0.47	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0002407.3	0.36	other (other), saccharide	angustmycin A, angustmycin C	Streptomyces angustmyceticus
BGC0001387.5	0.35	other (other)	nucleocidin	Streptomyces calvus
BGC0001591.4	0.32	other (other)	fatty acid enol ester, N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0002621.2	0.32	other (other)	angustmycin A, angustmycin B, angustmycin C, aristeromycin, arabinofuranosyladenine	Streptomyces angustmyceticus
BGC0001155.5	0.31	ribosomal	GE2270	Planobispora rosea
BGC0000604.4	0.30	ribosomal	GE2270A	Nonomuraea sp. WU8817
BGC0002713.2	0.30	NRPS	mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D	Photorhabdus laumondii subsp. laumondii
BGC0000027.4	0.30	PKS	ankaflavin, monascin, rubropunctatine, monascorubrin	Monascus pilosus
BGC0001089.5	0.26	NRPS, PKS	bacillaene	Bacillus velezensis FZB42

Regulator	Description
ArcA	Repressor of carbon oxidation

NZ_CP075971.1 - Region 1 - lanthipeptide-class-i

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Location: 43,440 - 69,585 nt. (total: 26,146 nt) Show pHMM detection rules used

lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0002576.2	0.74	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0001289.5	0.57	ribosomal	penisin	Paenibacillus ehimensis
BGC0000542.3	0.55	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000506.4	0.53	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000515.4	0.52	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0000559.4	0.51	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000560.5	0.51	ribosomal	subtilomycin	Bacillus subtilis
BGC0000537.3	0.51	ribosomal	nisin U	Streptococcus uberis
BGC0000536.3	0.51	ribosomal	nisin Q	Lactococcus lactis
BGC0000535.4	0.51	ribosomal	nisin A	Lactococcus lactis subsp. lactis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002576.2	0.74	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0001289.5	0.57	ribosomal	penisin	Paenibacillus ehimensis
BGC0000542.3	0.55	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000506.4	0.53	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000515.4	0.52	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0000559.4	0.51	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000560.5	0.51	ribosomal	subtilomycin	Bacillus subtilis
BGC0000537.3	0.51	ribosomal	nisin U	Streptococcus uberis
BGC0000536.3	0.51	ribosomal	nisin Q	Lactococcus lactis
BGC0000535.4	0.51	ribosomal	nisin A	Lactococcus lactis subsp. lactis

Identified secondary metabolite regions using strictness 'relaxed'

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Lanthipeptide(s) for KLF29_RS14845

antiSMASH-DB 4.0 matches for KLF29_RS14850

MIBiG 4.0 matches for KLF29_RS14850

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Regulator	Description
ANR	Anaerobic transcriptional regulator
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
CcpA	Catabolite control protein A
MogR	Repressor of flagellar motility genes
SypG	Regulator of biofilm formation and host colonization